CN106388929A - Isolated type square wave irreversible electroporation apparatus - Google Patents
Isolated type square wave irreversible electroporation apparatus Download PDFInfo
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- CN106388929A CN106388929A CN201610922442.0A CN201610922442A CN106388929A CN 106388929 A CN106388929 A CN 106388929A CN 201610922442 A CN201610922442 A CN 201610922442A CN 106388929 A CN106388929 A CN 106388929A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
- H02M3/00—Conversion of dc power input into dc power output
- H02M3/22—Conversion of dc power input into dc power output with intermediate conversion into ac
- H02M3/24—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters
- H02M3/28—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac
- H02M3/325—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal
- H02M3/335—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
- H02M3/33569—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only having several active switching elements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02B—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO BUILDINGS, e.g. HOUSING, HOUSE APPLIANCES OR RELATED END-USER APPLICATIONS
- Y02B70/00—Technologies for an efficient end-user side electric power management and consumption
- Y02B70/10—Technologies improving the efficiency by using switched-mode power supplies [SMPS], i.e. efficient power electronics conversion e.g. power factor correction or reduction of losses in power supplies or efficient standby modes
Abstract
The invention belongs to technologies of electronics as well as medical apparatus and instruments and relates to a tumour irreversible electroporation treatment instrument, in particular to an isolated type square wave irreversible electroporation apparatus. The isolated type square wave irreversible electroporation apparatus comprises a power supply conversion circuit, an energy storage circuit, an isolated type conversion circuit, a signal controller, an electrode, an acquisition output unit and a power supply, wherein the output terminal of the power supply is connected with the power supply conversion circuit, the power supply conversion circuit is sequentially connected with the isolated type conversion circuit by virtue of the energy storage circuit, the isolated type conversion circuit is respectively connected with the positive pole of the electrode and the acquisition output unit, the output terminal of the acquisition output unit is connected with an adjustment input terminal of the isolated type conversion circuit, the signal controller is respectively connected with control and isolated type conversion circuits of the power supply conversion circuit, and the energy storage circuit is also connected with the power supply conversion circuit. The isolated type square wave irreversible electroporation apparatus provided by the invention adopts isolated type conversion, the electrical safety of the irreversible electroporation apparatus is improved, less heat is produced in an electroporation process, and the isolated type square wave irreversible electroporation apparatus can be applied to in vivo or in vitro therapeutic experimental research of solid tumour therapy.
Description
Technical field
The invention belongs to electronics and medical instrumentation technology, particularly to tumour irreversibility electroporation treatment instrument, specifically
It is related to a kind of irreversible electroporation apparatus of isolated square wave.
Background technology
Electroporation is under Electro-pulsing Field, and cell membrane produces the physical process of micropore, and the electroporation of cell membrane is one
Plant phenomenon.Width and the difference of effect number of times are gone out according to impulse electric field strength, arteries and veins, electroporation is divided into reversible electroporation and irreversible
Electroporation；Reversible electroporation is to apply the electric field of suitable intensity and width in cell membrane, and impulse electric field makes phosphatide or phospholipoprotein
Temporary transient, reversible duct or penetrating is produced on film.When cell exposes in the electric field, cell membrane induces transmembrane voltage, if
When voltage exceedes some value, lead to membrane passage and electrical conductivity to dramatically increase, typically will increase several orders of magnitude,
After Electro-pulsing Field, duct natural enclosing, cell can recover normal condition, and the permeability due to film increases, in other fortune
The molecule that cell membrane can not be passed through under defeated mechanism can pass through cell membrane；Reversible electroporation makes intraor extracellular molecule exchange capacity show
Write and increase, be conducive to cell to absorb various medicines, genetic stew, protein and other macromolecular etc..
Electric pulse is combined with chemotherapeutics treatment tumour, has founded the electric pulse chemotherapy of tumour, and this method is than often
Rule chemotherapy effect is more preferable, and side effect is less.When impulse electric field exceedes the limit that cell can bear, after electric field, cell membrane
Can not reclose, cell expendable rupture and leads to cell death, and this phenomenon is referred to as irreversible electrical breakdown.It is
The irreversible electroporation of no generation, is had with the width of electric pulse, the physicochemical characteristics of impulse amplitude, pulse number and cell
Close.In the electroporation application study in past, such as gene transfection, tumour electrochemotherapy etc., using the invertibity electric shock of cell
Wear phenomenon, control irreversible electrical breakdown phenomenon.Electric pulse is induced one in tumor tissues, so that malignant cell is occurred can not
Inverse property electrical breakdown, destroys the life condition of tumour, has reached the purpose of killing tumor cell.This without chemotherapeutic
Thing, is used alone high intense pulsed electric field and can lead to tumour cell programmed death (apoptosis) and can effectively suppress the growth of tumour,
This tumor therapeuticing method is referred to as irreversible electroporation tumour ablation art.
Confirm through scholars' years of researches, impulse electric field strength used by irreversible electroporation is 1.5kV/cm, arteries and veins
Rushing width is that during 100 μ s, therapeutic effect is the most obvious, and therefore clinic electroporation apparatus is 3kV using impulse amplitude, pulse width
For the square-wave pulse of 100 μ s, maximum output current is up to 150kW up to 50A, pulse power.Treatment umber of pulse is 90 every time
Individual, pulse interval is 100～1000ms, and seance can create the zone of ablation of about 2cm × 2cm × 3cm, this pulse width
If degree and pulse power are directly isolated using pulse transforming, the weight of equipment will become unacceptable, therefore, great majority at present
Using the direct discharge mode of storage capacitor, if at the end of pulsatile once, the amplitude of square-wave voltage declines 5%, then energy storage electricity
The capacity holding is 33 μ F.Before therefore discharging, energy-storage capacitor needs to store the energy of 145J, and this is equivalent to external defibrillator and puts
The energy discharging when electric, this requires discharge circuit very reliable, otherwise, energy once breaking down, in storage capacitor
Amount is all released to patient, and this will bringing on a disaster property consequence.
Content of the invention
The purpose of the present invention is the problems referred to above and the deficiency solving prior art, the invention provides a kind of isolated square wave
Irreversible electroporation apparatus, it is square wave that the irreversible electricity of the present invention wears instrument output waveform, can reduce the product of heat in electroporation process
Raw, make living cells produce irreversible electrical breakdown, can be used for treatment of solid tumor in body or vitro treatment experimental study, carry
The high electrical security of irreversibility electroporation apparatus, to achieve these goals, the technical solution used in the present invention is as follows：
A kind of isolated irreversible electroporation apparatus, including power converting circuit, accumulator, isolated translation circuit, letter
Number controller, electrode, collection output unit and power supply, the output end of described power supply is connected with power converting circuit, the change of this power supply
Change circuit and pass sequentially through accumulator and be connected with the signal input part of isolated translation circuit, the output end of isolated translation circuit
Is connected with the input of the positive pole of electrode, collection output unit respectively, the output end of this collection output unit and isolated conversion
The regulation input of circuit connects, control signal, the isolated conversion with power converting circuit respectively of described signal controller
The control signal of circuit connects, the voltage output end of the described accumulator regulation input also with described power converting circuit
Connect.
It is preferred that described power converting circuit includes pulse-width modulation circuit, booster circuit, filter circuit and rectification circuit,
The signal output part of described pulse-width modulation circuit is connected with the control end of booster circuit, this booster circuit by filter circuit with
The input of described rectification circuit connects, and described power supply is also connected with the input of described booster circuit, filter circuit respectively, institute
The output end stating rectification circuit is connected with accumulator, the output end of described accumulator pass through described isolated translation circuit with
The positive pole of described electrode connects, and the output end of described accumulator is also connected with the regulation input of described pulse-width modulation circuit,
The output end of described isolated translation circuit is by the regulation of the described output end gathering output unit and isolated translation circuit
Input connects.
It is preferred that described pulse-width modulation circuit include PWM controller, resistance R1, resistance R2, resistance R3, adjustable resistance R4,
Resistance R5, electric capacity C1 and electric capacity C2, described booster circuit includes FET Q1, FET Q2 and step-up transformer T1, institute
State accumulator and include electric capacity C3 and electric capacity C4, described rectification circuit includes diode D1 and diode D2, described resistance R1's
One end is connected with the oscillating discharge output end of PWM controller, one end of described resistance R2 and the vibration timing resistor of PWM controller
Input connects, and one end of electric capacity C1 is connected with the vibration timing capacitor input of PWM controller, and described resistance R1's is another
End, the other end of the other end of resistance R2 and electric capacity C1 are all connected to ground, one end of described resistance R3, the one of adjustable resistance R4
End, the centre cap of adjustable resistance R4 are connected with PWM controller anti-phase error input, and the other end of adjustable resistance R4 is with ground even
Connect, the first complementary output end of described PWM controller is connected with the grid of FET Q1, the second of PWM controller is complementary defeated
Go out end to be connected with the grid of FET Q2, the drain electrode of described FET Q1 is connected with one end of step-up transformer T1 former limit tap
Connect, the source electrode of this FET Q1 respectively with the outside cut-off signals input of PWM controller, one end of resistance R5, field-effect
The source electrode of pipe Q2 connects, and the other end of described resistance R5 is connected to ground, the drain electrode of described FET Q2 and step-up transformer T1
The other end of former limit tap connects, and the centre cap of step-up transformer T1 is connected with the input of described power supply, filter circuit respectively
Connect, one end of described step-up transformer T1 secondary tap is connected with the anode of diode D1, the negative electrode of diode D2 respectively, described
The other end of step-up transformer T1 secondary tap is connected with the negative pole of electric capacity C3, the positive pole of electric capacity C4 respectively, described electric capacity C3's
Positive pole is connected with the signal input part of the other end of resistance R3, the negative electrode of diode D1, isolated translation circuit respectively, this isolation
The conversion output end of formula translation circuit is passed through to gather output unit feed back input to the regulation input of isolated translation circuit, institute
The negative pole stating electric capacity C4 is connected to ground, the electric capacity input of described PWM controller and the input/output control end of signal controller
Mouth connects.
It is preferred that described power supply is the alternating voltage of 0～36V, frequency is 30～100kHz.
It is preferred that the frequency of described PWM controller output is the square-wave pulse signal of 50kHz, this PWM controller adopts
Model IRF540 that model SG3525 chip, described FET Q1 and FET Q2 adopt is as switching tube.
It is preferred that described electric capacity C3, the capacitance of electric capacity C4 are not less than 2200 μ F, pressure voltage is not less than 450V.
It is preferred that described isolated translation circuit include high speed pulse width modulation controller, the first digital driver for isolating, the
Two digital driver for isolating, the first power amplifier, the second power amplifier, the 3rd power amplifier, the 4th power amplifier,
Isolating transformer T2, diode D3, diode D4, diode D5, diode D6, inductance L1 and electric capacity C6, described collection output
Unit includes resistance R6, current sense T3 and adjustable resistance R7, the Enable Pin of the described first digital driver for isolating, the second numeral
The Enable Pin of driver for isolating is connected with the input/output control port of signal controller respectively, described high speed pulse width modulation control
The first input end of the first output control terminal of device processed and the first digital driver for isolating, the second of the second digital driver for isolating
The second of the connection of input end, the second output control terminal of described high speed pulse width modulation controller and the first digital driver for isolating
Input, the first input end of the second digital driver for isolating connect；
The drain electrode of described first power amplifier, the drain electrode of the 3rd power amplifier and the output end of described accumulator connect
Connect, the first power amplifier grid is connected with the first drive output of the first digital driver for isolating, the first power amplifier
Source electrode be connected to ground, the grid of the second power amplifier is connected with the second drive output of the first digital driver for isolating,
The source electrode of the second power amplifier is connected to ground, the first drive of the grid of the 3rd power amplifier and the second digital driver for isolating
Dynamic output end connects, and the second drive output of the grid of described 4th power amplifier and the second digital driver for isolating is even
Connect, the source electrode of described 4th power amplifier is connected to ground, the source electrode of described first power amplifier, the second power amplifier
Drain electrode is connected with a tap of isolating transformer T2 former limit, the source electrode of described 3rd power amplifier, the 4th power amplifier
Drain electrode is connected with another tap of isolating transformer T2 former limit, and a tap of described isolating transformer T2 secondary is with diode D3's
Anode, negative electrode connection, another tap of described isolating transformer T2 secondary and the anode of diode D4, the diode of diode D5
The negative electrode of D6 connects even, and the negative electrode of described diode D3, the negative electrode of diode D4 are connected with one end of inductance L1 respectively, inductance L1
One end be connected with one end of resistance R6, the positive pole of electric capacity C6, the positive pole of electrode respectively, the negative pole of described electrode respectively with two poles
The anode of pipe D5, the anode of diode D6, the negative pole of electric capacity C6, a tap of current sense T3 former limit connect, and described electric current passes
Another tap of sense T3 former limit is connected with the other end of resistance R6, a tap of this current sense T3 secondary respectively with adjustable resistance
One end of R7, the centre cap of adjustable resistance R7, PWM controller anti-phase error input connect, current sense T3 secondary another
One tap, the other end of adjustable resistance R7 are connected to ground respectively.
It is preferred that the described first digital driver for isolating, the second digital driver for isolating adopt model Si82390 core
Piece, the model UC3825 control chip that described high speed pulse width modulation controller adopts, described first power amplifier, the second work(
Rate amplifier, the 3rd power amplifier, the 4th power amplifier adopt silicon carbide power MOSFET pipe or IGBT power tube, this carbon
The breakdown voltage of SiClx power MOSFET tube or IGBT power tube is 1200V.
It is preferred that the model C2M0025120D power tube that described silicon carbide power MOSFET pipe adopts.
In sum, the present invention is due to employing technique scheme, the invention has the advantages that：
(1), the present invention adopts isolated converter technique, improves the electrical security of irreversibility electroporation apparatus, reduces
The volume of equipment, decreases the weight of equipment, the waveform of isolated conversion output is square wave, can reduce heat in electroporation process
The generation of amount；
(2), the voltage of isolated pulse converter output adopts isolated current sense to detect output voltage, improves steady
The response speed of depressor, stabilizes the amplitude of output voltage, reduces the output impedance of converter and reduces to energy storage electricity
The charging voltage of container requires, thus reduces the resistance to pressure request to switching device.
(3), adopt isolated pulse converter, the amplitude of output pulse can be improved according to the no-load voltage ratio increasing transformer, expand
The therapeutic domain of big single ablation, reduces the ripple of output to the output waveform of isolated impulse transfer using LC wave filter,
Improve the rising trailing edge waveform along the river of output pulse.
Brief description
In order to be illustrated more clearly that present example or technical scheme of the prior art, below will be to embodiment or existing
Have technology description in required accompanying drawing do simply introduce it should be apparent that, drawings in the following description are only the present invention
Some examples, to those skilled in the art, on the premise of not paying creativeness, can also be attached according to these
Figure obtains other accompanying drawings.
Fig. 1 is a kind of theory diagram of the irreversible electroporation apparatus of isolated square wave of the present invention.
Fig. 2 is the power converting circuit theory diagram of the present invention.
Fig. 3 is the fundamental diagram of the power converting circuit of the present invention.
Fig. 4 is the fundamental diagram of the isolated translation circuit of the present invention.
Fig. 5 is the signal controller output waveform figure of the present invention.
Fig. 6 be the present invention step-up transformer conversion after output oscillogram.
Fig. 7 is the output waveform figure of the electrode of the present invention.
Specific embodiment
Below in conjunction with the accompanying drawing in present example, the technical scheme in the embodiment of the present invention is carried out clear, complete
Ground description is it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.It is based on and send out
Embodiment in bright, the every other enforcement that those of ordinary skill in the art are obtained under the premise of not making creative work
Example, broadly falls into the scope of protection of the invention.
Referring to Fig. 1, a kind of irreversible electroporation apparatus of isolated square wave, including power converting circuit 1, accumulator 2, isolation
Formula translation circuit 3, signal controller 4, electrode 5, collection output unit 6 and power supply 7, the output end of described power supply 7 is become with power supply
Change circuit 1 to connect, this power converting circuit 1 is passed sequentially through accumulator 2 and connected with the signal input part of isolated translation circuit 3
Connect, the output end of this isolated translation circuit 3 is connected with the positive pole of electrode 5, the input of collection output unit 6 respectively, and this is adopted
Collection output unit 6 output end be connected with the regulation input of isolated translation circuit 3, described signal controller 4 respectively with electricity
The control signal of source translation circuit 1, the control signal of isolated translation circuit 3 connect, and the voltage of described accumulator 3 is defeated
Go out end to be also connected with the regulation input of described power converting circuit 1.Described power supply 7 is the DC voltage of 0～36V, and frequency is
30～100kHz.In the embodiment of the present invention, it is the 24V electricity producing isolation and amplifier after Switching Power Supply mould is by the step-down of 220V civil power
Source voltage, carries out discharge and recharge by using 24V supply voltage to accumulator 2, to guarantee to export the amplitude size of pulse, energy storage
The tank voltage of circuit 2 output provides high energy pulse through isolated translation circuit 3 for electrode 5, in order to improve isolated conversion
The impulse amplitude of circuit 3 output, pressure, the raising velocity of discharge of the discharge switch reducing in output circuit, accumulator 2 adopts
Multiple electric capacity carry out the working method that energy storage in parallel or series carries out discharge and recharge, by controlling the work of isolated translation circuit 3
Time can obtain required square-wave pulse, and the amplitude of pulse determines the electric-field intensity that pulse is formed in tumor tissues, and electric
Field intensity determines ablation range and ablation effect, and electric-field intensity is too low, does not reach the electric-field intensity forming irreversibility electroporation,
And electric-field intensity is too high can damage normal structure.
In embodiments of the present invention, in conjunction with shown in Fig. 1, Fig. 2 and Fig. 3, described power converting circuit 1 includes pulsewidth modulation electricity
Road 100, booster circuit 101, filter circuit 102 and rectification circuit 103, the signal output part of described pulse-width modulation circuit 100 with
The control end of booster circuit 101 connects, the input by filter circuit 102 and described rectification circuit 103 of this booster circuit 101
End connects, and described power supply 7 is also connected with the input of described booster circuit 101, filter circuit 102 respectively, described rectification circuit
103 output end is connected with accumulator 2, the output end of described accumulator 2 pass through described isolated translation circuit 3 with described
The positive pole of electrode 5 connects, and the output end of described accumulator 2 is also connected with the regulation input of described pulse-width modulation circuit 100,
The output end of described isolated translation circuit 3 is by the tune of the described output end gathering output unit 6 and isolated translation circuit 3
Section input connects；Described pulse-width modulation circuit 100 includes PWM controller IC1, resistance R1, resistance R2, resistance R3, adjustable electric
Resistance R4, resistance R5, electric capacity C1 and electric capacity C2, described booster circuit 101 includes FET Q1, FET Q2 and boosting transformation
Device T1, described accumulator 2 includes electric capacity C3 and electric capacity C4, and described rectification circuit 102 includes diode D1 and diode D2, institute
Oscillating discharge output end DIS of one end and PWM controller IC1 of stating resistance R1 is connected, and one end of described resistance R2 is controlled with PWM
The vibration timing resistor input RT of device IC1 connects, and one end of electric capacity C1 is inputted with the vibration timing capacitor of PWM controller IC1
End CT connects, and the other end of the other end, the other end of resistance R2 and electric capacity C1 of described resistance R1 is all connected to ground, described resistance
One end of R3, one end of adjustable resistance R4, the centre cap of adjustable resistance R4 and PWM controller IC1 anti-phase error input INV
Connect, the other end of adjustable resistance R4 is connected to ground, the first complementary output end OUTA of described PWM controller IC1 and field-effect
The grid of pipe Q1 connects, and the second complementary output end OUTB of PWM controller IC1 is connected with the grid of FET Q2, described field
The drain electrode of effect pipe Q1 is connected with one end of step-up transformer T1 former limit tap, and the source electrode of this FET Q1 is controlled with PWM respectively
The outside cut-off signals input SD of device IC1 processed, one end of resistance R5, the source electrode of FET Q2 connect, described resistance R5's
The other end is connected to ground, and the drain electrode of described FET Q2 is connected with the other end of step-up transformer T1 former limit tap, rises buckling
The centre cap of depressor T1 is connected with the input of described power supply 7, filter circuit 103 respectively, described step-up transformer T1 secondary
One end of tap is connected with the anode of diode D1, the negative electrode of diode D2 respectively, described step-up transformer T1 secondary tap
The other end is connected with the negative pole of electric capacity C3, the positive pole of electric capacity C4 respectively, and the positive pole of described electric capacity C3 is another with resistance R3 respectively
End, the signal input part of the negative electrode of diode D1, isolated translation circuit 3 connect, the conversion output of this isolated translation circuit 3
End is by gathering output unit 6 feed back input to the regulation input of isolated translation circuit 3, the negative pole of described electric capacity C4 and ground
Connect, the electric capacity input SS of described PWM controller IC1 is connected with input/output control port I/O of signal controller 4.Institute
The frequency stating the output of PWM controller IC1 is the square-wave pulse signal of 50kHz, the model that this PWM controller IC1 adopts
SG3525 chip, model IRF540 that described FET Q1 and FET Q2 adopt as switching tube, described signal control
Device 4 processed adopts singlechip control chip.
In the present invention, as shown in figure 3, electric capacity input SS end (octal) of shown PWM controller IC1 and signal control
The input/output end port I/O of device 4 processed is connected, and during the input/output end port I/O output high level of this signal controller 4, PWM is controlled
Device IC1 processed is activated, and starts whole power converting circuit 1 and electric capacity is charged, as storage capacitor C3, electric capacity C4 charge.Described
PWM controller IC1 and its auxiliary element resistance R2, resistance R1 and electric capacity C1 constitute the oscillating circuit of PWM controller, and resistance R1 is
Discharge resistance, electric capacity C1 is timing capacitor, and when being timed electric discharge adjustment by PWM controller IC1, output two-way frequency is
The square-wave pulse of 50kHz, the width of this pulse is subject to output end E/AOUT the (the 9th of PWM controller IC1 internal error amplifier
Pin) on voltage control, FET Q1, FET Q2 and step-up transformer T1 constitute push-pull type translation circuit, will
The square-wave pulse that 24V AC power changes 50kHz into is applied to the former limit of step-up transformer T1, and produces in step-up transformer T1 secondary
Raw amplitude is 400V, frequency is the square-wave pulse of 50kHz, and therefore, electric capacity C3, the capacitance of electric capacity C4 are not less than 2200 μ F, pressure
Value is not less than 450V.Described diode D1, diode D2 and electric capacity C3, electric capacity C4 constitute voltage-multiplying type rectification circuit, and it will boost
Charge to electric capacity C3, electric capacity C4 after the output impulse commutation of transformer T1 secondary, the series equivalent electricity of electric capacity C3, electric capacity C4 composition
Hold as energy-storage capacitor, the Voltage Feedback of electric capacity C3 inputs the bleeder circuit constituting to resistance R3 and adjustable resistance R4 and is used for examining
Survey the voltage at energy-storage capacitor two ends, and feed back to the anti-phase error input INV of PWM controller IC1 internal error amplifier
(the first pin), when the output voltage (output voltage of electric capacity C3) of energy-storage capacitor raises, the error of PWM controller IC1
Anti-phase error input INV voltage raises, and output pulse width diminishes, and so that output voltage is declined；Adjust adjustable resistance R4
Change the charge value of storage capacitor, so that the inverting input INV (first pin) of PWM controller IC1 internal error amplifier is protected
Hold equal with 5.1V reference voltage, the in-phase input end NI (second pin) of PWM controller IC1 internal error amplifier and benchmark
End VREF (the 16th pin) is connected；PWM controller IC1 internal error amplifier to its in-phase input end NI (second pin) and
Voltage on inverting input INV (the first pin) is compared, and changes PWM controller according to the potential difference between them
Voltage in output end E/AOUT (the 3rd pin) of IC1 internal error amplifier, when isolated translation circuit 3 exports pulse width
When degree is more than arranges value, PWM controller IC1 exports the narrowed width of pulse, and output voltage declines, conversely, working as isolated conversion
When circuit 3 output pulse amplitude is less than arranges value, the width that PWM controller IC1 exports pulse broadens, and output voltage rises, this
Sample makes entirely isolated irreversible electroporation apparatus circuit form a close loop negative feedback it is ensured that the stability of output pulse amplitude；
Resistance R5 is current sense resistor, and its resistance value size is 20m Ω, and it is by the source current of FET Q1, FET Q2
It is converted into voltage, and deliver to the outside cut-off signals input SD (the tenth pin) of PWM controller IC1, to limit maximum charge
Electric current.When the voltage at resistance R5 two ends reaches 1V, FET Q1, FET Q2 are turned off by PWM controller IC1 immediately,
Start until the next work period.
In embodiments of the present invention, as shown in figure 4, described isolated translation circuit 3 includes high speed pulse width modulation controller
IC2, the first digital driver for isolating IC3, the second digital driver for isolating IC4, the first power amplifier QA, the second power amplification
Device QB, the 3rd power amplifier QC, the 4th power amplifier QD, isolating transformer T2, diode D3, diode D4, diode
D5, diode D6, inductance L1 and electric capacity C6, described collection output unit 6 includes resistance R6, current sense T3 and adjustable resistance
R7, Enable Pin EN1 of the described first digital driver for isolating IC3, the Enable Pin EN2 difference of the second digital driver for isolating IC4
It is connected with input/output control port I/O of signal controller 4, the first output control of described high speed pulse width modulation controller IC 2
The first input end VIA1 of end OUTA1 processed and the first digital driver for isolating IC3, the second of the second digital driver for isolating IC4
Input end IB2 connects, the second output control terminal OUTB2 of described high speed pulse width modulation controller IC 2 and first numeral isolation
Second input VIB2 of driver IC 3, the first input end VIA2 of the second digital driver for isolating IC4 connect；Described first
The drain electrode of power amplifier QA, the drain electrode of the 3rd power amplifier QC are connected with the output end of described accumulator 2, the first power
First drive output VOA1 of amplifier QA grid driver for isolating IC3 digital with first is connected, the first power amplifier QA
Source electrode be connected to ground, second drive output of the grid of the second power amplifier QB and the first digital driver for isolating IC3
VOB1 connects, and the source electrode of the second power amplifier QB is connected to ground, and the grid of the 3rd power amplifier QC and the second numeral are isolated
First drive output VOA2 of driver IC 4 connects, and the grid of described 4th power amplifier QD and the second numeral isolation are driven
Second drive output VOB2 of dynamic device IC4 connects, and the source electrode of described 4th power amplifier QD is connected to ground, described first work(
The source electrode of rate amplifier QA, the drain electrode of the second power amplifier QB are connected with a tap of isolating transformer T2 former limit, and described
The source electrode of three power amplifier QC, the drain electrode of the 4th power amplifier QD are connected with another tap of isolating transformer T2 former limit,
One tap of described isolating transformer T2 secondary is connected with the anode of diode D3, the negative electrode of diode D5, described isolation transformation
Another tap of device T2 secondary is connected with the negative electrode of the anode of diode D4, diode D6, the negative electrode of described diode D3, two
The negative electrode of pole pipe D4 is connected with one end of inductance L1 respectively, and one end of inductance L1 is respectively with one end of resistance R6, electric capacity C6 just
Pole, the positive pole of electrode 5 connect, the negative pole of described electrode 5 respectively with the anode of diode D5, the anode of diode D6, electric capacity C6
Negative pole, a tap of current sense T3 former limit connect, another tap of described current sense T3 former limit is another with resistance R6's
End connects, a tap of this current sense T3 secondary respectively with one end of adjustable resistance R7, the centre cap of adjustable resistance R7,
PWM controller IC1 anti-phase error input INV connects, another tap of current sense T3 secondary, the other end of adjustable resistance R7
It is connected to ground respectively.
In conjunction with shown in Fig. 1, Fig. 2, Fig. 3, Fig. 4 and Fig. 5, described PWM controller IC1 according to the control instruction of output pulse,
First complementary output end OUTA of PWM controller IC1, the second complementary output end OUTB export high level or low level respectively, defeated
When going out high level, corresponding FET Q1, FET Q2 turn on, during output low level, FET Q1, FET Q2
Conducting correspondingly ends.When FET Q1, FET Q2 turn on, the alternating voltage of 24V passes through by diode D1, two poles
Pipe D2 and electric capacity C3, electric capacity C4 constitute voltage-multiplying type rectification circuit, and the voltage that then exports sends in isolated translation circuit 3 the
The drain electrode of one power amplifier QA and the drain electrode of the 3rd power amplifier QC, electric capacity C3, electric capacity C4 adopt polypropylene film electric capacity
Device, its capacitance is not less than 2200 μ F, and pressure voltage is not less than 450V, has good temperature stability, ensures that capacitor is reliable
Work, noninductive characteristic, very high peak-to-peak value electric current and high frequency virtual value electric current can be born.The input/output control of signal controller 4
Port I/O processed passes through to control Enable Pin EN1 of the first digital driver for isolating IC3 and the second digital driver for isolating IC4 simultaneously
Enable Pin EN2, during the input/output control port I/O output high level of signal controller 4, the first digital driver for isolating
IC3, the second digital driver for isolating IC4 work, now, the first digital driver for isolating IC3 and second numeral driver for isolating
IC4 exports to the first output control terminal OUTA1 and the second output control terminal OUTB2 of high speed pulse width modulation controller IC 2 simultaneously
Pulse carry out Current amplifier, correspondingly, first drive output VOA1 of the first digital driver for isolating IC3 and the second driving
The electric current (or voltage) of output end VOB1 output is defeated equal to the first input end VIA1 of the first numeral driver for isolating IC3 and second
Enter to hold the curtage of VIB1), first drive output VOA2 and first of the second digital driver for isolating IC4 drives output
The electric current (or voltage) of end VOB2 output is equal to first input end VIA2 and second input of the second digital driver for isolating IC4
The electric current (or voltage) of VIB2；During the input/output control port I/O output low level of signal controller 4, the first numeral isolation
The digital driver for isolating IC4 of driver IC 3, second quits work, therefore input/output control port I/O of signal controller 4
Output high level duration (pulse width) is exactly the width of output pulse string, as shown in figure 5, defeated for signal controller 4
Go out waveform, by arrange signal controller 4 be output pulse string width, thus control apply electrode 5 on pulse width
Degree.
In the present invention, as shown in figure 4, described first digital driver for isolating IC3, the second digital driver for isolating IC4
Using model numeral driver for isolating Si82390 chip, the model that described high speed pulse width modulation controller IC 2 adopts
Two driver for isolating are carried out independent input control by signal controller 4 and combine by UC3825 control chip, output isolation
Drive signal, is particularly well-suited to drive the power supply MOSFET supporting to be up to 5kVrms and IGBT power tube.They have high common mode
Transient supression ability reaches 100kV/ μ s, and the low propagation delay time is 30ns, and reduces temperature, aging change and between part, output
UVLO fault detect and feedback can be automatically switched off two drivers, thus can have high reliability, described first numeral every
Also powered using three independent DC power supplies from the digital driver for isolating IC4 of driver IC 3, second, one is+5V, in addition two
Individual is+15V, is connected to filter capacitor C2_1, filter capacitor C2_2, filter capacitor in the feeder ear of three independent current sources
C2_3, filter capacitor C2_4, filter capacitor C2_5 and filter capacitor C2_6, these filter capacitors all adopt tantalum electric capacity, are used for disappearing
The interference causing except voltage transient, therefore, the unidirectional square-wave pulse of the exportable 3kV of the present invention, the rise time of pulse and decline
Time is less than 1 μ s, and pulse width is 100 μ s, and pulse current peak is up to 50A.
In embodiments of the present invention, as shown in figure 4, described first power amplifier QA, the second power amplifier QB, the 3rd
Power amplifier QC and the 4th power amplifier QD adopts silicon carbide power MOSFET pipe or IGBT power tube, described carborundum
The model C2M0025120D power tube that power MOSFET tube adopts, it is possible to provide switch at a high speed, this silicon carbide power MOSFET manages
Or the drain-source breakdown voltage of IGBT power tube is 1200V, the time of switch is less than 0.1 μ s, and conducting resistance is 25m Ω, pulse electricity
Stream is up to 250A.Isolating transformer T2 has two effects：One effect is that original edge voltage is boosted according to turn ratio；Another
Individual effect is to realize electrical isolation between primary and secondary side.First output control of described high speed pulse width modulation controller IC 2
End OUTA1 and the second output control terminal OUTB2 exports the two-way pwm signal of 180 ° of two-way phase, is simultaneously sent to the first number
The of the first input end VIA1 of word driver for isolating IC3 and the second input VIB1 and the second digital driver for isolating IC4
One input VIA2 and the second input VIB2, carries out Current amplifier and level conversion；Wherein, specific connected mode is by
The second input VIB2 of the digital driver for isolating IC4 of first input end VIA1 and second of one digital driver for isolating IC3 is even
Connect, the first input end of the digital driver for isolating IC4 of the second input VIB1 and second of the first digital driver for isolating IC3
VIA2 connects；The drain electrode of the first digital driver for isolating IC3 and the first power amplifier QA, the second power amplifier QB constitute one
Individual half-bridge, the second digital driver for isolating IC4 and the 3rd power amplifier QC, the 4th power amplifier QD constitute another partly
Bridge.The two-way pulse of high speed pulse width modulation controller IC 2 output, through the first digital driver for isolating IC3 and second numeral isolation
Driving switch pipe (i.e. the first power amplifier QA, the second power amplification respectively after the Current amplifier of driver IC 4 and level conversion
Device QB, the 3rd power amplifier QC and the 4th power amplifier QD on or off), make the first power amplifier QA, the 4th work(
Rate amplifier QD simultaneously turns on, and the second power amplifier QB and the 3rd power amplifier QC simultaneously turn on.When the first power amplification
When device QA, the 4th power amplifier QD conducting, the former limit of isolating transformer T2 is added positive voltage (+Vi), that is, Same Name of Ends is
Just；When the second power amplifier QB and the 3rd power amplifier QC turns on, the former limit of isolating transformer T2 is added negative electricity
Pressure (- Vi), that is, Same Name of Ends is negative, thus applying the square wave of alternation in the former limit of isolating transformer T2, according to circle on secondary
Number is than the square wave of sensing output alternation, and carries out rectification through diode D3, diode D4, diode D5 and diode D6, then
DC voltage Vo is exported by inductance L1 and electric capacity C6, it is straight that this output DC voltage Vo passes through therapeutic electrode 5 again after being filtered
Connect and be applied on target tissue.
In embodiments of the present invention, as shown in figure 4, resistance R6 is used for detecting the amplitude of output voltage, according to Ohm's law,
The electric current flowing through R6 is proportional to output voltage, and the secondary current of current transformer T3 is proportional to primary current, and electric current is mutual
Sensor T3 primary current is proportional to secondary output voltage, thus what the secondary current of current transformer T3 produced on resistance R7
Voltage Vs is proportional to output DC voltage Vo, and voltage Vs gives the inverting input of PWM controller IC1 internal error amplifier
INV (the first pin), when the impulse amplitude exporting DC voltage Vo after inductance L1 and electric capacity C6 is filtered is more than arranges value,
PWM controller IC1 exports the narrowed width of pulse, and after inductance L1 and electric capacity C6 is filtered, output DC voltage Vo declines.Instead
It, when the impulse amplitude exporting DC voltage Vo after inductance L1 and electric capacity C6 is filtered is less than arranges value, PWM controller
The width that IC1 exports pulse broadens, and inductance L1 and electric capacity C6 exports the rising of DC voltage Vo after being filtered.So make whole
Isolated irreversible electroporation apparatus circuit forms a close loop negative feedback it is ensured that the stability of output pulse amplitude.Impulse amplitude
Regulation by following two steps：First pass through the adjustable resistance R4 adjusting in Fig. 3, the charging voltage value of storage capacitor is entered
Row setting is so as to the value of ratio needs is somewhat higher；Then adjust adjustable resistance R7 in Fig. 4 adjusting voltage stabilizing amplitude.Adjustable
Resistance R4 and adjustable resistance R7 can also can be selected for digital regulation resistance from simulation potentiometer.
The present invention adopts the irreversible isolation technology of high-frequency electromagnetic, becomes the pulse width to be voltage conversion in storage capacitor first
1 μ s, frequency is the high-frequency impulse of 450kHz, after pulse isolation transformer T2 conversion, produces amplitude peak in its vice-side winding
The high-frequency impulse of frequency 900kHz for 3kV, after rectified filtering, produces the square-wave pulse of 100 μ s, and exports the amplitude of pulse
By pulse width modulation controlled, Fig. 6 is the waveform being exported by isolating transformer T2 after isolated translation circuit is modulated, and it exports width
Spending for 1.5kV, the amplitude stabilization of pulse being exported in setting value it is ensured that efficiently controlling using isolated form negative feedback network
The border of zone of ablation, improves the reliability of instrument and equipment, reduces the requirement to storage capacitor capacity；The present invention passes through to control
Isolated translation circuit 3 obtain required square-wave pulse, the amplitude of pulse determines the electricity that pulse is formed in tumor tissues
Field intensity, and electric-field intensity determines ablation range and ablation effect, electric-field intensity is too low, does not reach formation irreversibility electroporation
Electric-field intensity, and electric-field intensity is too high can damage normal structure.The following parameter of major control includes：The isolated conversion of the first
The startup of circuit 3 and closing, i.e. output pulse width；Next to that the number of times of pulse, when treatment starts, first, operating personnel's root
Determine the amplitude (1.5kV/cm) of output electric pulse according to the spacing that the volume of ablation tissue determines output electrode 5, by filtering it
Be added in field intensity E=V/L at the positive and negative the two poles of the earth of electrode 5 afterwards, V be the positive and negative the two poles of the earth of electrode 5 between voltage, the positive and negative the two poles of the earth of electrode 5 it
Between distance, nearer apart from L, field intensity is stronger, if through pulse isolation transformer T2 conversion after, its vice-side winding produce the most significantly
Spend for 3kV, the distance between positive and negative the two poles of the earth of electrode 5 L is 2cm, then can produce the electric-field intensity of 1.5kV/cm, satisfaction can not
Inverse electroporation technology requires, and Fig. 7 is the output waveform figure on electrode 5, and the as pulse amplitude of electroporation makes output electric-field intensity
The amplitude of output pulse, more than the threshold value (1.5kV/cm) of irreversibility electroporation, secondly, is set by signal controller 4,
The parameters such as pulse width, pulse number and pulse interval；Finally, the arranges value according to output pulse amplitude, shown in Fig. 5,
The charging voltage of storage capacitor charging source and the output amplitude of isolation type high frequency converter are set respectively by signal controller 4.
The foregoing is only the preferred embodiment of invention, not in order to limit the present invention, all spirit in the present invention
Within principle, any modification, equivalent substitution and improvement made etc., should be included within the scope of the present invention.
Claims (9)
1. a kind of irreversible electroporation apparatus of isolated square wave is it is characterised in that include power converting circuit (1), accumulator
(2), isolated translation circuit (3), signal controller (4), electrode (5), collection output unit (6) and power supply (7), described power supply
(7) output end is connected with power converting circuit (1), this power converting circuit (1) pass sequentially through accumulator (2) with isolated
The signal input part of translation circuit (3) connects, the output end of this isolated translation circuit (3) respectively with the positive pole of electrode (5), adopt
The input of collection output unit (6) connects, the regulation of the output end of this collection output unit (6) and isolated translation circuit (3)
Input connects, described signal controller (4) control signal, the isolated translation circuit with power converting circuit (1) respectively
(3) control signal connects, the regulation also with described power converting circuit (1) of the voltage output end of described accumulator (2)
Input connects.
2. a kind of isolated irreversible electroporation apparatus of square wave according to claim 1 is it is characterised in that described power conversion
Circuit (1) includes pulse-width modulation circuit (100), booster circuit (101), filter circuit (102) and rectification circuit (103), described
The signal output part of pulse-width modulation circuit (100) is connected with the control end of booster circuit (101), this booster circuit (101) logical
The input crossing filter circuit (102) with described rectification circuit (103) is connected, described power supply (7) also respectively with described liter of piezoelectricity
Road (101), the input of filter circuit (102) connect, and the output end of described rectification circuit (103) is connected with accumulator (2),
The output end of described accumulator (2) is connected with the positive pole of described electrode (5) by described isolated translation circuit (3), described
The output end of accumulator (2) is also connected with the regulation input of described pulse-width modulation circuit (100), described isolated conversion electricity
The output end on road (3) is connected with the regulation input of isolated translation circuit (3) by the output end of described collection output unit (6)
Connect.
3. a kind of isolated irreversible electroporation apparatus of square wave according to claim 2 is it is characterised in that described pulsewidth modulation
Circuit (100) includes PWM controller (IC1), resistance R1, resistance R2, resistance R3, adjustable resistance R4, resistance R5, electric capacity C1 and electricity
Hold C2, described booster circuit (101) includes FET Q1, FET Q2 and step-up transformer T1, described accumulator (2)
Including electric capacity C3 and electric capacity C4, described rectification circuit (102) includes diode D1 and diode D2, one end of described resistance R1 with
The oscillating discharge output end (DIS) of PWM controller (IC1) connects, and one end of described resistance R2 is shaken with PWM controller (IC1's)
Swing timing resistor input (RT) to connect, vibration timing capacitor input (CT) of one end of electric capacity C1 and PWM controller (IC1)
Connect, the other end of the other end, the other end of resistance R2 and electric capacity C1 of described resistance R1 is all connected to ground, described resistance R3's
One end, one end of adjustable resistance R4, the centre cap of adjustable resistance R4 and the anti-phase error input of PWM controller (IC1) (INV)
Connect, the other end of adjustable resistance R4 is connected to ground, first complementary output end (OUTA) of described PWM controller (IC1) and field
The grid of effect pipe Q1 connects, and second complementary output end (OUTB) of PWM controller (IC1) is connected with the grid of FET Q2
Connect, the drain electrode of described FET Q1 is connected with one end of step-up transformer T1 former limit tap, the source electrode of this FET Q1 divides
Not it is not connected with the source electrode of the outside cut-off signals input (SD) of PWM controller (IC1), one end of resistance R5, FET Q2,
The other end of described resistance R5 is connected to ground, the other end of the drain electrode of described FET Q2 and step-up transformer T1 former limit tap
Connect, the centre cap of step-up transformer T1 is connected with the input of described power supply (7), filter circuit (103) respectively, described liter
One end of pressure transformer T1 secondary tap is connected with the anode of diode D1, the negative electrode of diode D2 respectively, described boosting transformation
The other end of device T1 secondary tap is connected with the negative pole of electric capacity C3, the positive pole of electric capacity C4 respectively, and the positive pole of described electric capacity C3 is respectively
It is connected with the signal input part of the other end of resistance R3, the negative electrode of diode D1, isolated translation circuit (3), this isolated change
The conversion output end changing circuit (3) is passed through to gather output unit (6) feed back input to the regulation input of isolated translation circuit (3)
End, the negative pole of described electric capacity C4 is connected to ground, the electric capacity input (SS) of described PWM controller (IC1) and signal controller (4)
Input/output control port (I/O) connect.
4. a kind of isolated irreversible electroporation apparatus of square wave according to claim 3 is it is characterised in that described power supply (7)
Alternating voltage for 0～36V, frequency is 30～100kHz.
5. the irreversible electroporation apparatus of a kind of high frequency according to claim 3 is it is characterised in that described PWM controller (IC1)
The frequency of output is the square-wave pulse signal of 50kHz, the model SG3525 chip that this PWM controller (IC1) adopts, described field
Model IRF540 that effect pipe Q1 and FET Q2 adopts is as switching tube.
6. a kind of isolated irreversible electroporation apparatus of square wave according to claim 3 it is characterised in that described electric capacity C3,
The capacitance of electric capacity C4 is not less than 2200 μ F, and pressure voltage is not less than 450V.
7. a kind of isolated irreversible electroporation apparatus of square wave according to claim 3 is it is characterised in that described isolated change
Change circuit (3) and include high speed pulse width modulation controller (IC2), the first digital driver for isolating (IC3), the second digital isolation drive
Device (IC4), the first power amplifier (QA), the second power amplifier (QB), the 3rd power amplifier (QC), the 4th power amplification
Device (QD), isolating transformer T2, diode D3, diode D4, diode D5, diode D6, inductance L1 and electric capacity C6, described adopt
Collection output unit (6) includes resistance R6, current sense T3 and adjustable resistance R7, the described first digital driver for isolating (IC3)
Enable Pin (EN1), the second digital driver for isolating (IC4) Enable Pin (EN2) respectively with the input of signal controller (4)/defeated
Go out control port (I/O) to connect, first output control terminal (OUTA1) and first of described high speed pulse width modulation controller (IC2)
The first input end (VIA1) of digital driver for isolating (IC3), the second input end of the second digital driver for isolating (IC4)
(VIB2) connect, second output control terminal (OUTB2) of described high speed pulse width modulation controller (IC2) is driven with the first numeral isolation
Second input (VIB2) of dynamic device (IC3), the first input end (VIA2) of the second digital driver for isolating (IC4) connect；
The drain electrode of described first power amplifier (QA), the drain electrode of the 3rd power amplifier (QC) and described accumulator (2)
Output end connects, the first drive output of the first power amplifier (QA) grid and the first digital driver for isolating (IC3)
(VOA1) connect, the source electrode of the first power amplifier (QA) is connected to ground, the grid of the second power amplifier (QB) and first counts
Second drive output (VOB1) of word driver for isolating (IC3) connects, and the source electrode of the second power amplifier (QB) is connected to ground,
The grid of the 3rd power amplifier (QC) is connected with first drive output (VOA2) of the second digital driver for isolating (IC4),
Second drive output (VOB2) of the grid of described 4th power amplifier (QD) and the second digital driver for isolating (IC4) is even
Connect, the source electrode of described 4th power amplifier (QD) is connected to ground, the source electrode of described first power amplifier (QA), the second power
The drain electrode of amplifier (QB) is connected with a tap of isolating transformer T2 former limit, the source electrode of described 3rd power amplifier (QC),
The drain electrode of the 4th power amplifier (QD) is connected with another tap of isolating transformer T2 former limit, described isolating transformer T2 secondary
A tap be connected with the anode of diode D3, the negative electrode of diode D5, another tap of described isolating transformer T2 secondary with
The anode of diode D4, the negative electrode of diode D6 connect even, the negative electrode of described diode D3, the negative electrode of diode D4 respectively with electricity
One end of sense L1 connects, and one end of inductance L1 is connected with the positive pole of one end of resistance R6, the positive pole of electric capacity C6, electrode (5) respectively,
The negative pole of described electrode (5) respectively with the anode of diode D5, the anode of diode D6, the negative pole of electric capacity C6, current sense T3
One tap of former limit connects, and another tap of described current sense T3 former limit is connected with the other end of resistance R6, this current sense
One tap of T3 secondary is anti-phase with one end of adjustable resistance R7, the centre cap of adjustable resistance R7, PWM controller (IC1) respectively
Error input (INV) connects, and another tap of current sense T3 secondary, the other end of adjustable resistance R7 are connected to ground respectively.
8. the irreversible electroporation apparatus of a kind of isolated square wave according to claim 7 is it is characterised in that described first numeral
Driver for isolating (IC3), the second digital driver for isolating (IC4) adopt model Si82390 chip, described high speed pulse width modulation
The model UC3825 control chip that controller (IC2) adopts, described first power amplifier (QA), the second power amplifier
(QB), the 3rd power amplifier (QC), the 4th power amplifier (QD) adopt silicon carbide power MOSFET pipe or IGBT power tube,
The breakdown voltage of this silicon carbide power MOSFET pipe or IGBT power tube is 1200V.
9. a kind of isolated irreversible electroporation apparatus of square wave according to claim 8 is it is characterised in that described carborundum work(
The model C2M0025120D power tube that rate MOSFET pipe adopts.
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| CN112386800A (en) * | 2020-12-08 | 2021-02-23 | 上海健康医学院 | Inverter type defibrillation pulse generator |
| CN112439128A (en) * | 2020-12-08 | 2021-03-05 | 上海健康医学院 | Ultra-low voltage energy storage type cardiac defibrillator |
| CN112386800B (en) * | 2020-12-08 | 2023-10-24 | 上海健康医学院 | Inverse defibrillation pulse generator |
| CN114081614A (en) * | 2021-07-26 | 2022-02-25 | 上海健康医学院 | Pulsed electric field tissue ablation device |
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Effective date of registration: 20210118 Address after: 201616 12 buildings, 3 floors, No. 1, 618 Lane, Zhongde Road, Xiaokunshan Town, Songjiang District, Shanghai Applicant after: Shanghai Bekada Medical Technology Co.,Ltd. Address before: Science and Technology Department of Shanghai Health Medical College, 279 Zhouzhu Road, Pudong New Area, Shanghai, 201318 Applicant before: SHANGHAI University OF MEDICINE&HEALTH SCIENCES |
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