CN106466507A - A kind of isolated programmed electrical stimulation device - Google Patents
A kind of isolated programmed electrical stimulation device Download PDFInfo
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- CN106466507A CN106466507A CN201610905446.8A CN201610905446A CN106466507A CN 106466507 A CN106466507 A CN 106466507A CN 201610905446 A CN201610905446 A CN 201610905446A CN 106466507 A CN106466507 A CN 106466507A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/025—Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
- H02M3/00—Conversion of dc power input into dc power output
- H02M3/22—Conversion of dc power input into dc power output with intermediate conversion into ac
- H02M3/24—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters
- H02M3/28—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac
- H02M3/325—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal
- H02M3/335—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
- H02M3/33507—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of the output voltage or current, e.g. flyback converters
- H02M3/33523—Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of the output voltage or current, e.g. flyback converters with galvanic isolation between input and output of both the power stage and the feedback loop
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Power Engineering (AREA)
- Dc-Dc Converters (AREA)
Abstract
The invention belongs to medical device technology，A kind of specifically related to isolated programmed electrical stimulation device，Including isolated converter unit、Current Feedback Control unit、Current setting unit、Signal controller、Electrode、Power supply and signal indicating circuit，Described isolated converter unit is connected with signal controller，The signal output part of the isolated converter unit feedback input end with Current Feedback Control unit respectively、The voltage-regulation end input of current setting unit、The voltage input end of electrode connects，The signal control output end of the signal controller signal input part with signal indicating circuit respectively、The setting input of current setting unit connects，The current output terminal of this current setting unit is connected with Current Feedback Control unit control signal，The benchmark input end of isolated converter unit is connected with the feedback output end of Current Feedback Control unit，The pulse amplitude of the present invention、Width、Interval、Cycle、Number all can be adjusted flexibly，Fluctuation is little，Reliable and stable.
Description
Technical field
The invention belongs to medical device technology is and in particular to a kind of isolated programmed electrical stimulation device.
Background technology
The excitable tissue of composition neuromuscular colony can make a response to the stimulation such as heat, light, sound, pressure, chemistry, also can
Reaction is produced to electricity irritation, during excitable tissue's activity, various ions, mainly sodium ion and potassium ion, pass through rapidly
Cell membrane, causes the transient change of permeability of cell membrane, and this ion motion forms electric current, and this electric current produces electricity in human body surface
Field, it is also possible to reversing this process and applying an extraneous galvanism, makes to set up an ion stream in excitable tissue region.
Clinically, in order to recover bodily fuctions or treatment disease, electric current is directly applied to human body by electricity irritation.During electricity irritation, stream
Electronic current through wire be changed in tissue flowing ion current such that it is able to cause on excitable tissue's cell membrane across
Membrane charge is transmitted, and the purpose applying these electric currents is to make target N＆M depolarization and reach threshold voltage.
Typical stimulation pulse signal waveform has single-phase square wave, symmetrical biphasic square wave although square-wave pulse can be with depolarization
Neurolemma, but, due to its electrolysis to tissue stimulation with to electrode, typically without this pulse in clinical practice, make
Can obviously reduce electrochemical action with the impulse waveform of charge balance.Damage in order to allow above-mentioned chemical reaction to cause reduces to
Little, electrode can be allowed to work by the antimode of these reaction mechanisms.Because chemical reaction process is exactly the transfer process of electric charge, constant current
Type electric stimulus generator has more preferable control action compared with constant-pressure type generator, and constant0current generator allows in excursion in voltage,
Required electric current can be provided to the load impedance changing, the current constant of load is constant.In contrast, constant-pressure type generator output
Electric current becomes with biological tissue's impedance；In order to meet nerve, the particularly needs of the electrophysiological diagnosis of heart or treatment, stimulate arteries and veins
Rush amplitude, width, interval, cycle, number all can flexibly adjust.In order to meet the requirement of medical electrical equipment safety general, stimulate
The output par, c of device needs using the isolated way of output, to reduce the damage to cell membranes in tissue, safer to human body.
Content of the invention
The purpose of the present invention is the problems referred to above and the deficiency solving prior art, the invention provides a kind of isolated program control
Electrostimulator, the isolated programmed electrical stimulation device of the present invention can obtain higher output pulse amplitude, by negative feedback control plan
Slightly the electric current flowing through human body target tissue is regulated and controled, thus realizing constant current output, to achieve these goals, the present invention adopts
Technical scheme as follows：
A kind of isolated programmed electrical stimulation device, single including isolated converter unit, Current Feedback Control unit, electric current setting
Unit, signal controller, electrode, power supply and signal indicating circuit, the signal input part of described isolated converter unit and described letter
The signal enabling outfan of number controller connects, the signal output part of described isolated converter unit respectively with described current feedback
The feedback input end of control unit, the voltage-regulation end input of current setting unit, the voltage input end of electrode connect, described
The signal control output end of signal controller respectively with the signal input part of described signal indicating circuit, the setting of current setting unit
Put input to connect, the current output terminal of this current setting unit is connected with Current Feedback Control unit control signal, described
The benchmark input end of isolated converter unit is connected with the feedback output end of described Current Feedback Control unit, and described power supply is respectively
With the power input of described isolated converter unit, the power input of Current Feedback Control unit, current setting unit
Power input, the power input of signal controller connect.
Preferably, described isolated converter unit includes pulse-width modulation circuit, signal modulation amplifying circuit, isolation boosting change
Change circuit, rectification circuit and filter circuit, the signal output part of described pulse-width modulation circuit is inputted with signal modulation amplifying circuit
End connects, and the amplification outfan of this signal modulation amplifying circuit passes through isolation boosting translation circuit, rectification circuit and described filtering
Circuit connects, the outfan of this filter circuit feedback with the voltage input end of described electrode, Current Feedback Control unit respectively
Input, the voltage-regulation end input of current setting unit connect；
Described Current Feedback Control unit includes isolated operational amplifier and current compensation circuit, and described electric current setting is single
Unit includes digital regulation resistance and photoelectrical coupler, the negative input of described isolated operational amplifier, the electricity of digital regulation resistance
Pressure adjustable side, one end of current compensation circuit are all connected with the outfan of described filter circuit, described isolated operational amplifier
Feedback output end be connected with the benchmark input end of described pulse-width modulation circuit；
The other end of described current compensation circuit is connected with the common ground end of described isolated operational amplifier, described every
Electrode input end from formula operational amplifier is connected with the reference input of described isolated operational amplifier, described numeral current potential
The setting input of device is connected with the signal control output end of described signal controller by photoelectrical coupler.
Preferably, described pulse-width modulation circuit includes PWM controller, resistance R0, resistance R1, resistance R2, electric capacity C0, electric capacity
C1, electric capacity C2, signal modulation amplifying circuit includes the first driving amplifier and the second driving amplifier, described isolation boosting conversion
Circuit includes booster transformer T1, and described rectification circuit includes diode D1, diode D2, diode D3 and diode D4, institute
State filter circuit and include inductance L1 and electric capacity C4；
First complementary output end of described PWM controller passes through the signal input of resistance R1 and described first driving amplifier
End connects, and the signal output part of described first driving amplifier is connected with one end of described booster transformer T1 former limit tap, institute
The second complementary output end stating PWM controller is connected with the signal input part of described first driving amplifier by resistance R2, institute
The signal output part stating the second driving amplifier is connected with the other end of described booster transformer T1 former limit tap；Described liter of buckling
One end of depressor T1 secondary tap is connected with the anode of diode D1, the negative electrode of diode D2 respectively, described booster transformer T1
The other end of secondary tap is connected with the anode of diode D3, the negative electrode of diode D4 respectively, and one end of described inductance L1 is respectively
It is connected with the negative electrode of described diode D1, the negative electrode of diode D3, the other end of described inductance L1 is respectively with described electric capacity C4's
One end, the positive pole of electrode connect, and the anode of described diode D2, the anode of diode D4, the other end of electric capacity C4 are connected with each other
Be connected with the negative pole of described electrode more afterwards, the anode of described diode D2, the anode of diode D4, electric capacity C4 the other end mutual
After connection also more respectively with the negative input of described isolated operational amplifier, the voltage-regulation end of digital regulation resistance, electric current
All being connected with described one end of compensation circuit；
One end of described resistance R0 is connected with the vibration timing resistor input of PWM controller, and one end of electric capacity C0 is respectively
Be connected with the vibration timing capacitor input of PWM controller, the ramp input end of PWM controller, one end of electric capacity C2 respectively with
The in-phase input end of described PWM controller internal error amplifier, the benchmark input end of PWM controller connect, and described PWM controls
The electric capacity input of device is connected with one end of electric capacity C1, the input/output control end of signal controller respectively；Described resistance R0's
The other end, the other end of electric capacity C0, the other end of electric capacity C1, the other end of electric capacity C2 are all connected to ground, described PWM controller
Benchmark input end is connected with the feedback output end of described isolated operational amplifier also by resistance R5, described PWM controller
Modulation outfan is also connected with the feedback output end of described isolated operational amplifier.
Preferably, after the anode of described diode D2, the anode of diode D4, the other end of electric capacity C4 are connected with each other also again
By resistance R4 respectively with the negative pole of described electrode, the negative input of isolated operational amplifier, digital regulation resistance voltage
Adjustable side, one end of current compensation circuit connect.
Preferably, first complementary output end (OUTA) of described PWM controller (IC1) and described PWM controller (IC1)
The output frequency of the second complementary output end (OUTB) is the square-wave pulse signal of 30kHz～1MHz, and the phase of square-wave pulse signal
180 ° of phase difference.
Preferably, current compensation circuit includes resistance R3, electric capacity C5 and electric capacity C6, one end of described resistance R3, electric capacity C6
One end be connected with the negative input of described isolated operational amplifier respectively, the other end of described resistance R3 and described electric capacity
One end of C5 connects, the other end of described electric capacity C5, the other end of the electric capacity C6 public affairs with described isolated operational amplifier respectively
Earth terminal connects altogether.
Preferably, the span of described inductance L1 is 5 μ H～30 μ H, and the span of electric capacity C4 is 2.2nF～10nF.
In sum, the present invention is due to employing technique scheme, the invention has the advantages that：
(1), the present invention is modulated to the amplitude of output pulse using pulsewidth modulation and bridge drive circuit is isolated
Amplify, stabilize the amplitude of output voltage, reduce the output impedance of changer, simplify circuit, improve reliability；This
Bright setting by electric current is exported with Current Feedback Control pulse, and its fast response time, power density and stability aspect are all
Improve.
(2), the present invention is stimulated to tissue target using constant-current type square-wave pulse, and output current does not become with target tissue
Change, but also using isolated be the way of output, safer to human body,
(3), the boost pulse amplitude of the present invention, width, interval, cycle, number all can be adjusted flexibly, pulse period rate ripple
Dynamic little, reliable and stable.
Brief description
In order to be illustrated more clearly that present example or technical scheme of the prior art, below will be to embodiment or existing
Have technology description in required accompanying drawing do simply introduce it should be apparent that, drawings in the following description are only the present invention
Some examples, to those skilled in the art, on the premise of not paying creativeness, can also be attached according to these
Figure obtains other accompanying drawings.
Fig. 1 is a kind of theory diagram of isolated programmed electrical stimulation device of the present invention.
Fig. 2 is the theory diagram of the isolated converter unit of the present invention.
Fig. 3 is the fundamental diagram of the Current Feedback Control unit of the present invention.
Fig. 4 is the fundamental diagram of the current setting unit of the present invention.
Fig. 5 is the circuit theory diagrams of the isolated converter unit of the present invention.
Fig. 6 is the waveform of the signal controller output of the present invention.
Fig. 7 is the oscillogram on the booster transformer former limit of the present invention or secondary.
Fig. 8 is the current waveform figure of the filter circuit output of the present invention.
Specific embodiment
Below in conjunction with the accompanying drawing in present example, the technical scheme in the embodiment of the present invention is carried out clear, complete
Ground description is it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.It is based on and send out
Embodiment in bright, the every other enforcement that those of ordinary skill in the art are obtained under the premise of not making creative work
Example, broadly falls into the scope of protection of the invention.
Referring to Fig. 1, a kind of isolated programmed electrical stimulation device, including isolated converter unit 1, Current Feedback Control unit 2,
Current setting unit 3, signal controller 4, electrode 5, power supply 6 and signal indicating circuit 7, the letter of described isolated converter unit 1
Number input is connected with the signal enabling outfan of described signal controller 4, the signal output part of described isolated converter unit 1
Respectively with the feedback input end of described Current Feedback Control unit 2, the voltage-regulation end input of current setting unit 3, electrode 5
Voltage input end connect, the signal control output end signal with described signal indicating circuit 7 respectively of described signal controller 4
Input, the connection of setting input, the current output terminal of this current setting unit 3 and the current feedback control of current setting unit 3
Unit 2 control signal connection processed, the benchmark input end of described isolated converter unit 1 and described Current Feedback Control unit 2
Feedback output end connect, described power supply 6 power input, the Current Feedback Control with described isolated converter unit 1 respectively
The power input of unit 2, the power input of current setting unit 3, the power input of signal controller 4 connect.As
Embodiments of the invention, in conjunction with shown in Fig. 1 and Fig. 2, described isolated converter unit 1 includes pulse-width modulation circuit 100, signal is adjusted
Amplifying circuit 101 processed, isolation boosting translation circuit 102, rectification circuit 103 and filter circuit 104, described pulse-width modulation circuit
100 signal output part is connected with signal modulation amplifying circuit 101 input, and the amplification of this signal modulation amplifying circuit 101 is defeated
Go out end to be connected with described filter circuit 104 by isolation boosting translation circuit 102, rectification circuit 103, this filter circuit 104
Outfan respectively with the voltage input end of described electrode 5, the feedback input end of Current Feedback Control unit 2, current setting unit 3
Voltage-regulation end input connect；
As embodiments of the invention, as shown in Figure 3 and Figure 4, described Current Feedback Control unit 2 includes isolated computing
Amplifier IC4 and current compensation circuit 200, described current setting unit 3 includes digital regulation resistance IC5 and photoelectrical coupler IC6,
The negative input of described isolated operational amplifier IC4, the voltage-regulation end VH of digital regulation resistance IC5, current compensation circuit
200 one end is all connected with the outfan of described filter circuit 104, the feedback output end of described isolated operational amplifier IC4
It is connected with the benchmark input end of described pulse-width modulation circuit 100；The other end of described current compensation circuit 200 is isolated with described
The common ground end COMP of operational amplifier IC4 connects, the electrode input end of described isolated operational amplifier IC4 with described every
Reference input from formula operational amplifier IC4 connects, and the setting input of described digital regulation resistance IC5 passes through photoelectrical coupler
IC6 is connected with the signal control output end of described signal controller 4；As highly preferred embodiment of the present invention, as shown in figure 4, institute
State the anode of diode D2, the anode of diode D4, the other end of electric capacity C4 also pass through again after being connected with each other resistance R4 respectively with
The negative pole of described electrode 5, the negative input of isolated operational amplifier IC4, the voltage-regulation end VH of digital regulation resistance IC5,
One end of current compensation circuit 200 connects.
As highly preferred embodiment of the present invention, as shown in figure 3, described current compensation circuit 200 includes resistance R3, electric capacity C5
With electric capacity C6, one end of described resistance R3, one end of electric capacity C6 are inputted with the negative pole of described isolated operational amplifier IC4 respectively
End connects, and the other end of described resistance R3 is connected with one end of described electric capacity C5, the other end of described electric capacity C5, electric capacity C6 another
One end is connected with the common ground end COMP of described isolated operational amplifier IC4 respectively, and therefore, resistance R4 is pull-up resistor,
Resistance R3, electric capacity C5 and electric capacity C6 constitute the stability that current compensation circuit may insure output current.Described isolated computing
Amplifier IC4 adopts ADuM31901 chip, and this chip is highly suitable for linear feedback voltage or current control.
In the present invention, in conjunction with Fig. 1, Fig. 2, Fig. 3 and Fig. 4, signal controller 4 produces corresponding according to the setting of user
The square-wave pulse of output corresponding frequencies is controlling isolated converter unit 1, so that PWM is controlled isolated converter unit 1 and produced perseverance
Stream output pulse, and give tissue by stimulating electrode 5.Logical adopted isolated converter unit 1 as stimulate
Output circuit, is modulated to signal and has been amplified, consistent with input signal in outfan acquisition pulse width, pulse current
Output current, and human body target tissue is applied to by electrode 5, the setting input of digital regulation resistance IC5 passes through photoelectrical coupler
IC6 is connected with the signal control output end of described signal controller 4, and this photoelectrical coupler IC6 exports to digital regulation resistance IC5
Signal carries out reverse isolation, prevents the current signal arranging disturbed, meanwhile, isolated converter unit 1 crosses negative feedback control
System strategy regulates and controls to the electric current flowing through human body target tissue, thus realizing constant current output, described digital regulation resistance IC5 adopts
X9C102 digital regulation resistance chip, photoelectrical coupler IC6 adopts PC817X4 bonder, and described signal controller 4 adopts single-chip microcomputer
Or FPGA controller.
In embodiments of the present invention, as shown in figure 5, described pulse-width modulation circuit 30 include PWM controller IC1, resistance R0,
Resistance R1, resistance R2, electric capacity C0, electric capacity C1, electric capacity C2, signal modulation amplifying circuit 101 include the first driving amplifier IC2 and
Second driving amplifier IC3, described isolation boosting translation circuit 102 includes booster transformer T1, and described rectification circuit 103 includes
Diode D1, diode D2, diode D3 and diode D4, described filter circuit 104 includes inductance L1 and electric capacity C4；Described electricity
One end of resistance R0 is connected with the vibration timing resistor input RT of PWM controller IC1, one end of electric capacity C0 respectively with PWM control
The vibration timing capacitor input CT of device IC1, the ramp input end RAMP of PWM controller IC1 connect, and one end of electric capacity C2 is respectively
Connect with the in-phase input end NV of described PWM controller IC1 internal error amplifier, the benchmark input end VREF of PWM controller IC1
Connect, the electric capacity input SS of the described PWM controller IC1 input/output control with one end of electric capacity C1, signal controller 4 respectively
End I/O processed connects；The other end of described resistance R0, the other end of electric capacity C0, the other end of electric capacity C1, electric capacity C2 the other end all
It is connected to ground, the benchmark input end VREF of described PWM controller IC1 is also by resistance R5 and described isolated operational amplifier
The feedback output end of IC4 connects, the modulation outfan EAO of described PWM controller IC1 also with described isolated operational amplifier
The feedback output end of IC4 connects, wherein, the first complementary output end OUTA of described PWM controller IC1 pass through resistance R1 with described
Signal input part connection, the signal output part of described first driving amplifier IC2 and the described boosting of the first driving amplifier IC2
One end connection, the signal output part of described second driving amplifier IC3 and the described booster transformer of transformator T1 former limit tap
The other end of T1 former limit tap connects；Second complementary output end OUTB of described PWM controller IC1 passes through resistance R2 and described the
The signal input part of two driving amplifier IC3 connects.In the present invention, timing resistor R0 and timing capacitor C0 constitute PWM controller
IC1 control circuit hunting of frequency starting current, makes the first complementary output end OUTA of PWM controller IC1 and described PWM controller
The output frequency of the second complementary output end OUTB of IC1 is the square-wave pulse signal of 30kHz～1MHz, and square-wave pulse signal
It is preferred that output two-way frequency is 500kHz, electric capacity C1 and C2 is 15V power supply and reference power supply to 180 ° of phase respectively
Filter capacitor, for eliminating the interference in circuit.The pulse width of two complementary output end outputs is subject to described PWM controller
The control of modulation outfan EAO (the 3rd pin) output voltage of IC1, PWM controller IC1 adopts UC3825 modulation chip, institute
State the defeated of the first complementary output end OUTA of PWM controller IC1 and the second complementary output end OUTB of described PWM controller IC1
The pulse going out inputs the first driving amplifier IC2 and the second driving amplifier IC3 by resistance R1, resistance R2 respectively and constitutes bridge
Formula drive circuit carries out isolation and amplifies, for driving the former limit of booster transformer T1, described first driving amplifier IC2 and second
The model complementary type mosfet driver MIC4452 chip that driving amplifier IC3 adopts, MIC4452 driver can replace
Three or more discrete components, thus reduce the area requirements of wiring board, simplify product design, reduce and be assembled into
This.
In the present invention, one end anode, diode with diode D1 respectively of described booster transformer T1 secondary tap
The negative electrode of D2 connects, the other end of described booster transformer T1 secondary tap respectively with the anode of diode D3, diode D4
Negative electrode connects, and one end of described inductance L1 is connected with the negative electrode of described diode D1, the negative electrode of diode D3 respectively, described inductance
The other end of L1 is connected with one end of described electric capacity C4, the positive pole of electrode 5 respectively, the anode of described diode D2, diode D4
Anode, the other end of electric capacity C4 be connected with the negative pole of described electrode 5 again after being connected with each other, the span of described inductance L1 is
The span of 5 μ H～30 μ H, electric capacity C4 is 2.2nF～10nF；The anode of described diode D2, the anode of diode D4, electricity
Hold C4 the other end be connected with each other after also more respectively with the negative input of described isolated operational amplifier IC4, digital current potential
The voltage-regulation end VH of device IC5, being all connected with described one end of current compensation circuit 200.
As shown in Figure 3 and Figure 4, current setting unit 3 output current setting up procedure is：Due to degenerative effect, entirely
Circuit forms a close loop negative feedback ring it is therefore necessary to keep end of oppisite phase-IN (the negative pole input of isolated operational amplifier IC4
End or the 11st pin) voltage equal with the voltage of in-phase end+IN (electrode input end or the 12nd pin), isolated computing
In-phase end+the IN and reference input REF of amplifier IC4OUTIt is connected, reference input REFOUTReference voltage be 1.225V,
With the voltage of the voltage-regulation end VH (the 3rd pin) of holding digital regulation resistance IC5 as 1.225V, therefore pass through signal controller 4
Setting and the resistance changing digital regulation resistance IC5, you can the first complementary output end OUTA to described PWM controller IC1 and institute
The output pulse stating the second complementary output end OUTB of PWM controller IC1 is controlled, thus reaching control PWM controller IC1
The purpose of output pulse width.Additionally, in order that whole outfan isolation, digital current potential digital regulation resistance IC5 and signal control
Data exchange between device 4 is isolated using photoelectrical coupler IC6,
Booster transformer T1 has two effects, and one is for electrical isolation, and another is transformation, when in booster transformer
When T1 former limit applies square-wave pulse, you can produce square-wave pulse, its pulse amplitude and liter buckling in the secondary of booster transformer T1
The turn ratio of depressor T1 is proportional, and the square-wave pulse on booster transformer T1 secondary is through diode D1, diode D2, diode D3
Constitute bridge rectifier with diode D4, then constitute output DC current after LC wave filter through inductance L1 and electric capacity C4.Letter
Number controller 4 passes through the current potential of the electric capacity input SS (the 8th pin) of PWM controller IC1, you can control PWM controller IC1
Startup.When the electric capacity input SS (the 8th pin) of PWM controller IC1 is high level, output voltage is high level, when
When the electric capacity input SS (the 8th pin) of PWM controller IC1 is low level, its output voltage is low level, therefore, it can control
The width of pulse processed, interval, cycle, number.The waveform of the control signal of signal controller 4 output is as shown in fig. 6, Fig. 7 is to rise
Waveform in pressure transformer T1 former limit or secondary.The current waveform that Fig. 8 exports for filter circuit, draws assorted from 3 oscillograms
Conclusion.Pass through as can be seen here, after high frequency modulated, obtain the constant-current type square wave current of isolation in outfan.
The skill that the isolated operational amplifier of ADuM3190 is formed with X9C102 digital regulation resistance chip and PC817X4 bonder
Art scheme all increases in terms of transient response, power density and stability, and fast response time is it is allowed to feedback control loop is to quick
Transient condition and excessively stream condition are made a response.The also built-in high accuracy 1.225V base of ADuM3190 isolated operation amplifier device
Reference voltage source, can be compared with the set point of current setting unit 3, the isolation voltage of the isolated operational amplifier of ADuM3190
Rated value is 2.5kV rms, and the isolated operational amplifier of ADuM3190 is used as output voltage VOUTError amplify feedback, and
Using a resitstance voltage divider on the-IN pin of the isolated operational amplifier of ADuM3190, compared with+IN pin, this configuration is anti-
Turn the output signal of common ground end COMP (the tenth pin)；The inside connection of this common earth terminal COMP (the tenth pin)+
1.225V reference voltage terminal (i.e. reference input REFOUT), and+1.225V reference voltage terminal (i.e. reference input REFOUT) even
Connect in-phase end+IN pin, as shown in figure 3, the feedback voltage of ADuM3190 isolated operational amplifier IC4 is derived from IOUTIn numeral
The upper voltage producing of potentiometer core IC5 (X9C102 chip), therefore, when output current IOUTWhen being declined due to load change, will
Produce an electric current becoming low in common earth terminal COMP (the tenth pin) output of the isolated operational amplifier of ADuM3190.
Modulation output EAO (the 6th pin) of the isolated operational amplifier of ADuM3190 is followed common earth terminal COMP pin and is changed into low electricity
Flat, the feedback output end EA of the isolated operational amplifier of ADuM3190OUT2Connect the benchmark of PWM controller IC1 by resistance R5
Input VREF (the 16th pin), meanwhile, the feedback output end EA of the isolated operational amplifier of ADuM3190OUT2It is also connected with
The modulation outfan EAO (the 3rd pin) of PWM controller IC1, as the benchmark input end VREF of PWM controller IC1, (the 16th draws
Foot) for low level when make the common earth terminal COMP (the tenth pin) of the isolated operational amplifier of ADuM3190 export to be changed into high electricity
Flat.Latch PWM controller IC1 during common earth terminal COMP (the tenth pin) high level of the isolated operational amplifier of ADuM3190 to produce
Raw pwm pulse dutycycle output, this pwm pulse dutycycle output driving power stage, lift electrode 5 cathode voltage VOUT, Zhi Daoqi
Return voltage stabilizing state.The electric current very little being exported due to the modulation outfan EAO (the 3rd pin) of PWM controller IC1, for modulating
The pulse width of pwm pulse signal, the voltage of its output is higher, and pwm pulse signal is narrower, the isolated operation amplifier of ADuM3190
The feedback output end EA of deviceOUT2After being connected with the modulation outfan EAO (the 3rd pin) of PWM controller IC1, PWM will be deprived
Controller IC 1 is weighed to the regulation and control of pwm pulse signal, and the benchmark input end VREF (the 16th pin) of PWM controller IC1 exports
Electric current is very strong, and is the feedback output end EA of the isolated operational amplifier of ADuM3190 by pull-up resistor R5OUT2Electric current is provided,
Feedback output end EAOUT2To export for open-drain, therefore, output voltage will be determined by the isolated operational amplifier of ADuM3190
Fixed.In the present invention, it is 5V that described power supply 6 adopts a road, and supply signal controller 4 uses, and another road is 15V, and supply is isolated
Converter unit 1, Current Feedback Control unit 2, current setting unit 3 and signal indicating circuit 7 use, wherein, signal designation electricity
Road 7 is LCD liquid crystal display, for showing the parameters such as boost pulse amplitude, width, interval, cycle.
The foregoing is only the preferred embodiment of invention, not in order to limit the present invention, all spirit in the present invention
Within principle, any modification, equivalent substitution and improvement made etc., should be included within the scope of the present invention.
Claims (7)
1. a kind of isolated programmed electrical stimulation device it is characterised in that：Including isolated converter unit (1), Current Feedback Control list
First (2), current setting unit (3), signal controller (4), electrode (5), power supply (6) and signal indicating circuit (7), described isolation
The signal input part of formula converter unit (1) is connected with the signal enabling outfan of described signal controller (4), described isolated change
Change signal output part feedback input end, the current setting unit with described Current Feedback Control unit (2) respectively of unit (1)
(3) voltage-regulation end input, the voltage input end of electrode (5) connect, and the signal of described signal controller (4) controls output
End is connected with the signal input part of described signal indicating circuit (7), the setting input of current setting unit (3) respectively, this electricity
The current output terminal of stream arranging unit (3) is connected with Current Feedback Control unit (2) control signal, and described isolated conversion is single
The benchmark input end of first (1) is connected with the feedback output end of described Current Feedback Control unit (2), described power supply (6) respectively with
The power input of described isolated converter unit (1), the power input of Current Feedback Control unit (2), electric current setting are single
The power input of first (3), the power input of signal controller (4) connect.
2. a kind of isolated programmed electrical stimulation device according to claim 1 is it is characterised in that described isolated converter unit
(1) pulse-width modulation circuit (100), signal modulation amplifying circuit (101), isolation boosting translation circuit (102), rectification circuit are included
(103) and filter circuit (104), the signal output part of described pulse-width modulation circuit (100) and signal modulation amplifying circuit (101)
Input connects, and the amplification outfan of this signal modulation amplifying circuit (101) passes through isolation boosting translation circuit (102), rectification
Circuit (103) is connected with described filter circuit (104), the outfan electricity with described electrode (5) respectively of this filter circuit (104)
Pressure input, the feedback input end of Current Feedback Control unit (2), the voltage-regulation end input of current setting unit (3) connect
Connect；
Described Current Feedback Control unit (2) includes isolated operational amplifier (IC4) and current compensation circuit (200), described
Current setting unit (3) includes digital regulation resistance (IC5) and photoelectrical coupler (IC6), described isolated operational amplifier (IC4)
Negative input, the voltage-regulation end (VH) of digital regulation resistance (IC5), current compensation circuit (200) one end all with described
Outfan connection, the feedback output end of described isolated operational amplifier (IC4) and the described pulsewidth modulation of filter circuit (104)
The benchmark input end of circuit (100) connects；
The other end of described current compensation circuit (200) and the common ground end of described isolated operational amplifier (IC4)
(COMP) connection, the electrode input end of described isolated operational amplifier (IC4) and described isolated operational amplifier (IC4)
Reference input connects, and the setting input of described digital regulation resistance (IC5) passes through photoelectrical coupler (IC6) and described signal control
The signal control output end of device (4) processed connects.
3. a kind of isolated programmed electrical stimulation device according to claim 2 is it is characterised in that described pulse-width modulation circuit
(30) PWM controller (IC1), resistance R0, resistance R1, resistance R2, electric capacity C0, electric capacity C1, electric capacity C2 are included, signal modulation is amplified
Circuit (101) includes the first driving amplifier (IC2) and the second driving amplifier (IC3), described isolation boosting translation circuit
(102) include booster transformer T1, described rectification circuit (103) includes diode D1, diode D2, diode D3 and diode
D4, described filter circuit (104) includes inductance L1 and electric capacity C4；
First complementary output end (OUTA) of described PWM controller (IC1) passes through resistance R1 and described first driving amplifier
(IC2) signal input part connects, and the signal output part of described first driving amplifier (IC2) is former with described booster transformer T1
One end of side tap connects, and second complementary output end (OUTB) of described PWM controller (IC1) passes through resistance R2 and described first
Signal input part connection, the signal output part of described second driving amplifier (IC3) and the described boosting of driving amplifier (IC2)
The other end of transformator T1 former limit tap connects；One end sun with diode D1 respectively of described booster transformer T1 secondary tap
Pole, the negative electrode of diode D2 connect, the other end of described booster transformer T1 secondary tap respectively with the anode of diode D3, two
The negative electrode of pole pipe D4 connects, and one end of described inductance L1 is connected with the negative electrode of described diode D1, the negative electrode of diode D3 respectively,
The other end of described inductance L1 is connected with one end of described electric capacity C4, the positive pole of electrode (5) respectively, the sun of described diode D2
Pole, the anode of diode D4, the other end of electric capacity C4 are connected with the negative pole of described electrode (5) after being connected with each other again, described two poles
The anode of pipe D2, the anode of diode D4, the other end of electric capacity C4 are also put with described isolated computing after being connected with each other respectively again
The negative input of big device (IC4), the voltage-regulation end (VH) of digital regulation resistance (IC5), current compensation circuit (200) all with
Described one end connects；
One end of described resistance R0 is connected with vibration timing resistor input (RT) of PWM controller (IC1), one end of electric capacity C0
Ramp input end (RAMP) with vibration timing capacitor input (CT) of PWM controller (IC1), PWM controller (IC1) respectively
Connect, one end of electric capacity C2 is controlled with the in-phase input end (NV) of described PWM controller (IC1) internal error amplifier, PWM respectively
The benchmark input end (VREF) of device (IC1) processed connects, the electric capacity input (SS) of described PWM controller (IC1) respectively with electric capacity
One end of C1, the input/output control end (I/O) of signal controller (4) connect；The other end of described resistance R0, electric capacity C0
The other end, the other end of electric capacity C1, the other end of electric capacity C2 are all connected to ground, the benchmark input end of described PWM controller (IC1)
(VREF) it is connected with the feedback output end of described isolated operational amplifier (IC4) also by resistance R5, described PWM controller
(IC1) modulation outfan (EAO) is also connected with the feedback output end of described isolated operational amplifier (IC4).
4. a kind of isolated programmed electrical stimulation device according to claim 3 is it is characterised in that the sun of described diode D2
It is negative with described electrode (5) respectively that pole, the anode of diode D4, the other end of electric capacity C4 also pass through resistance R4 after being connected with each other again
Pole, the negative input of isolated operational amplifier (IC4), the voltage-regulation end (VH) of digital regulation resistance (IC5), current compensation
One end of circuit (200) connects.
5. a kind of isolated programmed electrical stimulation device according to claim 3 is it is characterised in that described PWM controller (IC1)
The first complementary output end (OUTA) and the output frequency of the second complementary output end (OUTB) of described PWM controller (IC1) be
The square-wave pulse signal of 30kHz～1MHz, and 180 ° of the phase of square-wave pulse signal.
6. a kind of isolated programmed electrical stimulation device according to claim 2 is it is characterised in that current compensation circuit (200)
Including resistance R3, electric capacity C5 and electric capacity C6, one end of described resistance R3, one end of electric capacity C6 are put with described isolated computing respectively
The negative input of big device (IC4) connects, and the other end of described resistance R3 is connected with one end of described electric capacity C5, described electric capacity C5
The other end, the other end of electric capacity C6 is connected with the common ground end (COMP) of described isolated operational amplifier (IC4) respectively.
7. a kind of isolated programmed electrical stimulation device according to claim 3 is it is characterised in that the value model of described inductance L1
Enclose for 5 μ H～30 μ H, the span of electric capacity C4 is 2.2nF～10nF.
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| CN108390561A (en) * | 2018-03-06 | 2018-08-10 | 安徽卓越动力科技有限公司 | A kind of DC/DC DCPS digitally controlled power sources design |
| CN111632270A (en) * | 2019-03-01 | 2020-09-08 | 上海库石医疗技术有限公司 | Human body electrotherapy device with safety protection function |
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| TWI814559B (en) * | 2021-12-29 | 2023-09-01 | 精能醫學股份有限公司 | Electrical stimulation method and system for impedance compensation |
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