CN106377627A - Medicine for assisting interventional therapy of liver cancer - Google Patents

Medicine for assisting interventional therapy of liver cancer Download PDF

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Publication number
CN106377627A
CN106377627A CN201610867742.3A CN201610867742A CN106377627A CN 106377627 A CN106377627 A CN 106377627A CN 201610867742 A CN201610867742 A CN 201610867742A CN 106377627 A CN106377627 A CN 106377627A
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parts
medicine
explosion
extract
freeze
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郭英昌
赵鹏
宋珊珊
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First Affiliated Hospital of Xinxiang Medical University
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First Affiliated Hospital of Xinxiang Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a medicine for assisting interventional therapy of liver cancer. The medicine is prepared from the following components in parts by weight: 15 to 25 parts of fourstamen stephania root, 10 to 15 parts of milk thistle extract, 11 to 15 parts of date leaves, 8 to 12 parts of mussaenda pubescens, 12 to 18 parts of pine needle extract, 10 to 15 parts of flos mume, 12 to 18 parts of common nostoc freeze-drying powder, 8 to 10 parts of herba hyperici japonici, 5 to 10 parts of Chinese walnut tree bark, 10 to 15 parts of olive leaf extract, 10 to 15 parts of borago officinalis, and 12 to 17 parts of cranberry fermenting powder. The medicine has the advantages that the effects of detoxifying and eliminating stagnation, activating blood circulation and removing blood stasis, and invigorating Qi and nourishing Yin are realized, and the functions of killing cancer cells, inhibiting growth of the cancer cells, controlling disease development, protecting livers, and improving immunity are realized; the medicine adopts natural ingredients, the administration is safe, any obvious side effect is avoided, and the medicine is suitable for a patient to take for a long time.

Description

A kind of medicine for assisting chemoembolization of hepatic carcinoma
Technical field
The present invention relates to field of traditional Chinese is and in particular to a kind of medicine for assisting chemoembolization of hepatic carcinoma.
Background technology
Liver cancer refers to betide the malignant tumour of liver, including primary carcinoma of liver and two kinds of metastatic hepatic carcinoma, is clinically One of modal malignant tumour.The treatment method first-selection operative treatment of current clinically liver cancer, by complete tumor resection Tissue reaches the purpose of healing, but Resection Rate is low, and there is recurrence and the risk of transfer.In addition with RF ablation, micro- Ripple ablation, high intensity focused ultrasound, Chemoembolization, alinjection, cold therapy, radiotherapy, molecular targeted therapy, immunity are controlled The methods such as treatment, and the liver cancer vascular interventional treatment that clinic is most frequently with present.
Liver cancer vascular interventional treatment refers to, through femoral arteriography, cancer therapy drug or suppository are injected a kind of hepatic arterial area Domain property local treatment, is the prefered method that non-abdominal treats liver cancer, including selective hepatic arterial infusion treatment, selective liver Arterial embolism and selective hepatic arterial chemoembolization.Liver cancer vascular interventional treatment belongs to magnetic target therapy, determined curative effect, mechanism section Learn, operation is simple, safe and reliable, patient that is old and simultaneously suffering from some diseases is also suitable, diagnosis radiography is clear Clear, may be repeated, medical expense is relatively low, but there is also simultaneously side effect substantially, cancer cell kill thoroughly, operation difficult The problems such as spend high.
Primary carcinoma of liver is diseases caused by external factors Shi Re Bing Pian, or feeding desorder on the basis of positive unsaturated vapor, or feelings will is lost Adjust, ultimately result in the dirty functional disturbance of internal organs, phlegm knot is wet poly-, and in heat toxin, knot, qi depression to blood stasis, mutually cementing hardly possibleization, gather in liver, long and It, send out as liver cancer long.In recent years, domestic many scholars are combined PCI with traditional Chinese medicine, control improving Hepatic cancer Treat the aspects such as curative effect, mitigation chemotherapy toxic side effect, raising life quality to make great progress.
Content of the invention
Object of the present invention is to provide a kind of medicine for assisting chemoembolization of hepatic carcinoma, there is detoxicating and resolving a mass, work Blood and dissolving stasis, supplementing qi and nourishing yin, kill cancer cell, inhibition cancer cell growth, symptom management development, improve immunologic function, ensure liver Effect.This medicine mostly using natural component, take safety, non-evident effect, suitable patient's Long-Time Service.
For achieving the above object, the technical scheme that the present invention takes is：
A kind of medicine for assisting chemoembolization of hepatic carcinoma, is prepared from by the component of following weight portion：
Hemsley rockvine root 15-25 part, Milk Thistle grass extract 10-15 part, red date leaf 11-15 part, celestial sweet rattan 8-12 part, pine needle Extract 12-18 part, FLOS MUME 10-15 part, nostoc freeze-dried powder 12-18 part, hypericum japonicum 8-10 part, hickory nut bark 5-10 Part, Olive leaf P.E 10-15 part, Common Borage 10-15 part, Cranberry yeast powder 12-17 part.
Wherein, described Milk Thistle grass extract prepares gained by following steps：
The Milk Thistle grass being dried is placed in 90% methyl alcohol or the ethanol solution that flash extracter adds 6 times of volumes, processes 1-3 and divide Clock, after separation of solid and liquid, reclaims methyl alcohol or ethanol solution, concentrates so that extract is in paste, then with water-saturated n-butanol to carrying Take thing to extract 3 times, after recycling design, by drying concentrated in vacuo for extract, obtain Milk Thistle grass extract.
Wherein, described extract from pine needles prepares gained by following steps：
Pine needle after cleaning is placed in steam-explosion jar, being passed through nitrogen to steam explosion pressure inside the tank is 0.9-2.1MPa, at explosion Reason 7-13min, after being cooled to room temperature, adds the 90% of 3 times of volumes ethanol solution, is placed in ultrasonic extractor, under room temperature Ultrasonic extraction 35-50min, extraction terminates, recycling design, is spray-dried, obtains extract from pine needles.
Wherein, nostoc freeze-dried powder prepares gained by following steps：
Take nostoc after cleaning, to be placed in steam explosion in steam-explosion jar to process three times, freeze-drying obtains nostoc freeze-dried powder；Q wherein, It is 0.6-0.9Mpa, temperature 65-95 degree Celsius, time 7-23min that first time explosion treatment keeps pressure, second explosion treatment Holding pressure is 0.9-1.1Mpa, temperature 95-115 degree Celsius, time 0.8-1.2min, and third time explosion treatment holding pressure is 3-5Mpa, temperature 70-90 degree Celsius, time 0.8-2.8min.
Wherein, described freeze-drying includes pre-freeze process separate explosion process, distillation processes separate explosion and processes, and pre-freeze process is secondary Explosion treatment selects quick-frozen mode, and pre-freezing temperature is 23 DEG C, pre-freeze time 7h；Process separate explosion in distillation to process, sublimation temperature For -10.5 DEG C, vacuum is 270pa, sublimation time 230min.
Wherein, described Olive leaf P.E prepares gained by following steps：
It is placed in steam-explosion jar after olive leaf is cleaned, being passed through nitrogen to steam explosion pressure inside the tank is 1.5-2.1MPa, and steam is quick-fried After tear reason 0.8-2.8min, after being cooled to room temperature, add by cellulase：Alkali protease in mass ratio 1:2 mixing gained Complex enzyme, compound enzyme dosage be raw material weight 0.5-2%, at being maintained at 30-45 DEG C digest 0.5-2h, filter, obtain enzymolysis Liquid；Enzymolysis liquid directly passes through neutral alumina column, and resin column blade diameter length ratio is 1: 5-1: 10, respectively with 1-4 times of cylinder ponding, 1-3 The wash-out removal of impurities of times column volume 95% ethanol solution, with 0.3-0.6% glacial acetic acid -55% ethanol (1 of 5-7 times of column volume:1) solution Wash-out, collects eluent；After flinging to glacial acetic acid and the ethanol in eluent, micro-wave vacuum, obtain Olive leaf P.E.
Wherein, described Cranberry yeast powder prepares gained by following steps：
By fresh Cranberry after ultramicro grinding, according to the ratio microbe inoculation leavening of inoculum concentration 1.5-1.7%, Keeping temperature 25-35 DEG C, after fermentation 48-54 hour, high-temperature inactivation, low temperature drying, grind to form fine powder, obtain Cranberry yeast powder.
Wherein, described microbe leaven is by Bacillus acidi lactici, bacillus licheniformis, Corynebacterium glutamicum in mass ratio 1:3: 2 mixing gained.
The invention has the advantages that：
There is detoxicating and resolving a mass, promoting blood circulation, supplementing qi and nourishing yin, kill cancer cell, inhibition cancer cell grows, symptom management is sent out Exhibition, the effect improving immunologic function, ensureing liver.This medicine mostly using natural component, take safety, non-evident effect, fit Close patient's Long-Time Service.
Specific embodiment
In order that objects and advantages of the present invention become more apparent, with reference to embodiments the present invention is carried out further Describe in detail.It should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to limit this Bright.
In following examples, the Milk Thistle grass extract being used prepares gained by following steps：
The Milk Thistle grass being dried is placed in 90% methyl alcohol or the ethanol solution that flash extracter adds 6 times of volumes, processes 1-3 and divide Clock, after separation of solid and liquid, reclaims methyl alcohol or ethanol solution, concentrates so that extract is in paste, then with water-saturated n-butanol to carrying Take thing to extract 3 times, after recycling design, by drying concentrated in vacuo for extract, obtain Milk Thistle grass extract.
The extract from pine needles being used prepares gained by following steps：
Pine needle after cleaning is placed in steam-explosion jar, being passed through nitrogen to steam explosion pressure inside the tank is 0.9-2.1MPa, at explosion Reason 7-13min, after being cooled to room temperature, adds the 90% of 3 times of volumes ethanol solution, is placed in ultrasonic extractor, under room temperature Ultrasonic extraction 35-50min, extraction terminates, recycling design, is spray-dried, obtains extract from pine needles.
The nostoc freeze-dried powder being used prepares gained by following steps：
Take nostoc after cleaning, to be placed in steam explosion in steam-explosion jar to process three times, freeze-drying obtains nostoc freeze-dried powder；Q wherein, It is 0.6-0.9Mpa, temperature 65-95 degree Celsius, time 7-23min that first time explosion treatment keeps pressure, second explosion treatment Holding pressure is 0.9-1.1Mpa, temperature 95-115 degree Celsius, time 0.8-1.2min, and third time explosion treatment holding pressure is 3-5Mpa, temperature 70-90 degree Celsius, time 0.8-2.8min；Wherein, described freeze-drying is included at pre-freeze process separate explosion Reason, distillation process separate explosion and process, and pre-freeze process separate explosion processes and selects quick-frozen mode, and pre-freezing temperature is 23 DEG C, the pre-freeze time 7h；Process separate explosion in distillation to process, sublimation temperature is -10.5 DEG C, vacuum is 270pa, sublimation time 230min.
The Olive leaf P.E being used prepares gained by following steps：
It is placed in steam-explosion jar after olive leaf is cleaned, being passed through nitrogen to steam explosion pressure inside the tank is 1.5-2.1MPa, and steam is quick-fried After tear reason 0.8-2.8min, after being cooled to room temperature, add by cellulase：Alkali protease in mass ratio 1:2 mixing gained Complex enzyme, compound enzyme dosage be raw material weight 0.5-2%, at being maintained at 30-45 DEG C digest 0.5-2h, filter, obtain enzymolysis Liquid；Enzymolysis liquid directly passes through neutral alumina column, and resin column blade diameter length ratio is 1: 5-1: 10, respectively with 1-4 times of cylinder ponding, 1-3 The wash-out removal of impurities of times column volume 95% ethanol solution, with 0.3-0.6% glacial acetic acid -55% ethanol (1 of 5-7 times of column volume:1) solution Wash-out, collects eluent；After flinging to glacial acetic acid and the ethanol in eluent, micro-wave vacuum, obtain Olive leaf P.E.
The Cranberry yeast powder being used prepares gained by following steps：
By fresh Cranberry after ultramicro grinding, according to the ratio microbe inoculation leavening of inoculum concentration 1.5-1.7%, Keeping temperature 25-35 DEG C, after fermentation 48-54 hour, high-temperature inactivation, low temperature drying, grind to form fine powder, obtain Cranberry yeast powder, Wherein, described microbe leaven is by Bacillus acidi lactici, bacillus licheniformis, Corynebacterium glutamicum in mass ratio 1:3:2 mixing institutes ?.
The other medicinal materials being used are commercially available.
Embodiment 1
A kind of medicine for assisting chemoembolization of hepatic carcinoma, is prepared from by the component of following weight portion：
15 parts of hemsley rockvine root, Milk Thistle 10 parts of extract of grass, 11 parts of red date leaf, 8 parts of celestial sweet rattan, 12 parts of extract from pine needles, 10 parts of FLOS MUME, 12 parts of nostoc freeze-dried powder, 8 parts of hypericum japonicum, 5 parts of hickory nut bark, 10 parts of Olive leaf P.E, Common Borage 10 Part, 12 parts of Cranberry yeast powder.
Embodiment 2
A kind of medicine for assisting chemoembolization of hepatic carcinoma, is prepared from by the component of following weight portion：
25 parts of hemsley rockvine root, Milk Thistle 15 parts of extract of grass, 15 parts of red date leaf, 12 parts of celestial sweet rattan, 18 parts of extract from pine needles, 15 parts of FLOS MUME, 18 parts of nostoc freeze-dried powder, 10 parts of hypericum japonicum, 10 parts of hickory nut bark, 15 parts of Olive leaf P.E, Common Borage 15 parts, 17 parts of Cranberry yeast powder.
Embodiment 3
A kind of medicine for assisting chemoembolization of hepatic carcinoma, is prepared from by the component of following weight portion：
20 parts of hemsley rockvine root, Milk Thistle 12.5 parts of extract of grass, 13 parts of red date leaf, 10 parts of celestial sweet rattan, extract from pine needles 15 Part, 12.5 parts of FLOS MUME, 15 parts of nostoc freeze-dried powder, 9 parts of hypericum japonicum, 7.5 parts of hickory nut bark, Olive leaf P.E 12.5 Part, 12.5 parts of Common Borage, 14.5 parts of Cranberry yeast powder.
Through substantial amounts for the treatment of case practice, the anti-tumor agent of the present embodiment gained has detoxicating and resolving a mass, promoting blood circulation, benefit Gas yin-nourishing, kills cancer cell, inhibition cancer cell growth, symptom management development, the effect of raising immunologic function, and therapeutic effect shows Write, and have no that patient has bad reaction, suitable patient's Long-Time Service.
The above is only the preferred embodiment of the present invention it is noted that ordinary skill people for the art For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (8)

1. a kind of medicine for assisting chemoembolization of hepatic carcinoma is it is characterised in that be prepared from by the component of following weight portion：
Hemsley rockvine root 15-25 part, Milk Thistle grass extract 10-15 part, red date leaf 11-15 part, celestial sweet rattan 8-12 part, pine needle extract Thing 12-18 part, FLOS MUME 10-15 part, nostoc freeze-dried powder 12-18 part, hypericum japonicum 8-10 part, hickory nut bark 5-10 part, olive Olive leaf extract 10-15 part, Common Borage 10-15 part, Cranberry yeast powder 12-17 part.
2. according to claim 1 a kind of medicine for assisting chemoembolization of hepatic carcinoma it is characterised in that described Milk Thistle grass carries Thing is taken to prepare gained by following steps：
The Milk Thistle grass being dried is placed in 90% methyl alcohol or the ethanol solution that flash extracter adds 6 times of volumes, processes 1-3 minute, After separation of solid and liquid, reclaim methyl alcohol or ethanol solution, concentrate so that extract is in paste, then with water-saturated n-butanol to extraction Thing extracts 3 times, after recycling design, by drying concentrated in vacuo for extract, obtains Milk Thistle grass extract.
3. according to claim 1 a kind of medicine for assisting chemoembolization of hepatic carcinoma it is characterised in that described pine needle extract Thing prepares gained by following steps：
Pine needle after cleaning is placed in steam-explosion jar, being passed through nitrogen to steam explosion pressure inside the tank is 0.9-2.1MPa, explosion treatment 7- 13min, after being cooled to room temperature, adds the 90% of 3 times of volumes ethanol solution, is placed in ultrasonic extractor, ultrasonic under room temperature Extract 35-50min, extraction terminates, recycling design, be spray-dried, obtain extract from pine needles.
4. according to claim 1 a kind of medicine for assisting chemoembolization of hepatic carcinoma it is characterised in that nostoc freeze-dried powder Prepare gained by following steps：
Take nostoc after cleaning, to be placed in steam explosion in steam-explosion jar to process three times, freeze-drying obtains nostoc freeze-dried powder；Q wherein, first Separate explosion processes and keeps pressure to be 0.6-0.9Mpa, temperature 65-95 degree Celsius, time 7-23min, and second explosion treatment keeps Pressure is 0.9-1.1Mpa, temperature 95-115 degree Celsius, time 0.8-1.2min, and it is 3- that third time explosion treatment keeps pressure 5Mpa, temperature 70-90 degree Celsius, time 0.8-2.8min.
5. according to claim 4 a kind of medicine for assisting chemoembolization of hepatic carcinoma it is characterised in that described freeze-drying Process separate explosion process including pre-freeze, distillation processes separate explosion and processes, pre-freeze processes separate explosion process and selects quick-frozen mode, pre-freeze Temperature is 23 DEG C, pre-freeze time 7h；Process separate explosion in distillation to process, sublimation temperature is -10.5 DEG C, vacuum is 270pa, rises Magnificent time 230min.
6. according to claim 1 a kind of medicine for assisting chemoembolization of hepatic carcinoma it is characterised in that described olive leaf carries Thing is taken to prepare gained by following steps：
It is placed in steam-explosion jar after olive leaf is cleaned, being passed through nitrogen to steam explosion pressure inside the tank is 1.5-2.1MPa, at steam blasting After reason 0.8-2.8min, after being cooled to room temperature, add by cellulase：Alkali protease in mass ratio 1:2 mix answering of gained Synthase, compound enzyme dosage is the 0.5-2% of raw material weight, digests 0.5-2h at being maintained at 30-45 DEG C, filters, obtains enzymolysis liquid；Enzyme Solution liquid directly passes through neutral alumina column, and resin column blade diameter length ratio is 1: 5-1: 10, respectively with 1-4 times of cylinder ponding, 1-3 times of cylinder Long-pending 95% ethanol solution wash-out removal of impurities, with 0.3-0.6% glacial acetic acid -55% ethanol (1 of 5-7 times of column volume:1) eluant solution, Collect eluent；After flinging to glacial acetic acid and the ethanol in eluent, micro-wave vacuum, obtain Olive leaf P.E.
7. according to claim 1 a kind of medicine for assisting chemoembolization of hepatic carcinoma it is characterised in that described Cranberry sends out Ferment powder prepares gained by following steps：
By fresh Cranberry after ultramicro grinding, according to the ratio microbe inoculation leavening of inoculum concentration 1.5-1.7%, keep Temperature 25-35 DEG C, after fermentation 48-54 hour, high-temperature inactivation, low temperature drying, grind to form fine powder, obtain Cranberry yeast powder.
8. according to claim 7 a kind of medicine for assisting chemoembolization of hepatic carcinoma it is characterised in that described microorganism sends out Ferment agent is by Bacillus acidi lactici, bacillus licheniformis, Corynebacterium glutamicum in mass ratio 1:3:2 mixing gained.
CN201610867742.3A 2016-09-30 2016-09-30 Medicine for assisting interventional therapy of liver cancer Pending CN106377627A (en)

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Cited By (1)

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CN106937747A (en) * 2017-02-24 2017-07-11 江苏食品药品职业技术学院 One kind is sobered up lozenge and preparation method thereof

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CN105920194A (en) * 2016-04-24 2016-09-07 新乡医学院 Anti-tumor traditional Chinese medicinal agent

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CN106937747A (en) * 2017-02-24 2017-07-11 江苏食品药品职业技术学院 One kind is sobered up lozenge and preparation method thereof

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