CN106937747A - One kind is sobered up lozenge and preparation method thereof - Google Patents
One kind is sobered up lozenge and preparation method thereof Download PDFInfo
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- CN106937747A CN106937747A CN201710106019.8A CN201710106019A CN106937747A CN 106937747 A CN106937747 A CN 106937747A CN 201710106019 A CN201710106019 A CN 201710106019A CN 106937747 A CN106937747 A CN 106937747A
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- 239000007937 lozenge Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 63
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 47
- 244000202052 Poncirus trifoliata Species 0.000 claims abstract description 27
- 235000000404 Poncirus trifoliata Nutrition 0.000 claims abstract description 27
- 241000320380 Silybum Species 0.000 claims abstract description 27
- 235000010841 Silybum marianum Nutrition 0.000 claims abstract description 27
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 26
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 26
- 240000007817 Olea europaea Species 0.000 claims abstract description 25
- 235000002725 Olea europaea Nutrition 0.000 claims abstract description 25
- 235000004936 Bromus mango Nutrition 0.000 claims abstract description 22
- 235000014826 Mangifera indica Nutrition 0.000 claims abstract description 22
- 235000009184 Spondias indica Nutrition 0.000 claims abstract description 22
- 235000007516 Chrysanthemum Nutrition 0.000 claims abstract description 18
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 17
- 244000068988 Glycine max Species 0.000 claims abstract description 15
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 15
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 15
- 229920001184 polypeptide Polymers 0.000 claims abstract description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 15
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 15
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 15
- 235000009566 rice Nutrition 0.000 claims abstract description 15
- 235000012907 honey Nutrition 0.000 claims abstract description 13
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 12
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 12
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 240000007228 Mangifera indica Species 0.000 claims abstract description 8
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims abstract description 4
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims abstract description 4
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 claims abstract description 4
- 240000007594 Oryza sativa Species 0.000 claims abstract 5
- 238000004880 explosion Methods 0.000 claims description 72
- 239000006228 supernatant Substances 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000003960 organic solvent Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
- 241000723353 Chrysanthemum Species 0.000 claims description 17
- 108091005804 Peptidases Proteins 0.000 claims description 15
- 239000004365 Protease Substances 0.000 claims description 15
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 15
- 239000008367 deionised water Substances 0.000 claims description 15
- 229910021641 deionized water Inorganic materials 0.000 claims description 15
- 239000003480 eluent Substances 0.000 claims description 15
- 238000000227 grinding Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 15
- 235000019419 proteases Nutrition 0.000 claims description 15
- 239000011347 resin Substances 0.000 claims description 15
- 229920005989 resin Polymers 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 11
- 102000004190 Enzymes Human genes 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 10
- 101000693530 Staphylococcus aureus Staphylokinase Proteins 0.000 claims description 10
- 229960000583 acetic acid Drugs 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 229940088598 enzyme Drugs 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000000796 flavoring agent Substances 0.000 claims description 10
- 235000019634 flavors Nutrition 0.000 claims description 10
- 239000012362 glacial acetic acid Substances 0.000 claims description 10
- 239000012510 hollow fiber Substances 0.000 claims description 10
- 239000012528 membrane Substances 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 238000001556 precipitation Methods 0.000 claims description 10
- 238000000108 ultra-filtration Methods 0.000 claims description 10
- 244000025254 Cannabis sativa Species 0.000 claims description 5
- 108010059892 Cellulase Proteins 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000003513 alkali Substances 0.000 claims description 5
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 5
- 229940106157 cellulase Drugs 0.000 claims description 5
- 238000000748 compression moulding Methods 0.000 claims description 5
- 238000001125 extrusion Methods 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 238000005469 granulation Methods 0.000 claims description 5
- 230000003179 granulation Effects 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 238000002844 melting Methods 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- 230000007935 neutral effect Effects 0.000 claims description 5
- 238000001179 sorption measurement Methods 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 238000000967 suction filtration Methods 0.000 claims description 5
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 abstract description 6
- 235000013361 beverage Nutrition 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 abstract description 3
- 230000035622 drinking Effects 0.000 abstract description 3
- 206010019233 Headaches Diseases 0.000 abstract description 2
- 230000002075 anti-alcohol Effects 0.000 abstract description 2
- 231100000869 headache Toxicity 0.000 abstract description 2
- 239000003053 toxin Substances 0.000 abstract description 2
- 231100000765 toxin Toxicity 0.000 abstract description 2
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract 1
- 241001093152 Mangifera Species 0.000 description 14
- 241000209094 Oryza Species 0.000 description 10
- 238000010828 elution Methods 0.000 description 10
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 235000015203 fruit juice Nutrition 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 239000001293 FEMA 3089 Substances 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 241000779819 Syncarpia glomulifera Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 238000007323 disproportionation reaction Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001739 pinus spp. Substances 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229940036248 turpentine Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Sober up lozenge and preparation method thereof, be prepared from by the raw material of following parts by weight the invention discloses one kind：Careless 10 15 parts of the extract of 15 25 parts of black soya bean polypeptide, 10 20 parts of rice protein extract, 30 40 parts of mango juice, Milk Thistle, 12 18 parts of trifoliate orange Dulcis freeze-dried powders, 39 parts of powder of green plum enzymolysis, 36 parts of bitter chrysanthemum, 5 15 parts of kudzu root extract, 5 10 parts of Olive leaf P.E, 8 12 parts of honey, 48 parts of maltodextrin.The present invention is using black soya bean polypeptide as primary raw material, cooperate with using cooperatively for the careless extract of homemade mango juice, Milk Thistle, trifoliate orange Dulcis freeze-dried powders etc., so that the beverage of gained has good Antialcoholic liver-protecting function, and it is good in taste, also there is protecting liver and expelling toxin, alleviate and have a headache after drinking, alcohol content in blood reduced, while by the use of alcohol dehydrogenase and acetaldehyde dehydrogenase, substantially increasing the sober-up function of lozenge, and it is harmless to the body, do not result in burden of liver.
Description
Technical field
The present invention relates to field of biological pharmacy, and in particular to one kind is sobered up lozenge and preparation method thereof.
Background technology
Wine is a kind of bland containing Multiple components, wherein topmost composition be ethanol (i.e. alcohol) this be to cause wine
Liquor-saturated principal element.The absorption of ethanol and metabolic mechanism are：Ethanol is absorbed into blood circulation of human body by stomach and enteron aisle, so
The metabolic breakdown of ethanol is carried out afterwards.The reason for why people can be drunk, is that the content by acetaldehyde in human body is determined：Because human body
A certain amount of ethanol can only be metabolized under normal circumstances, and when drinking excessive, oxidation of ethanol is increased for the amount of acetaldehyde, and human body is to second
The decomposition of aldehyde is limited within a certain period of time.When acetaldehyde is too high, human body can not be decomposed in time, and acetaldehyde enters blood simultaneously
Absorbed, caused to human body vitals and function major injury.There is brains excited, have a dizzy spell, vomiting and various discomforts
Phenomenon, here it is so-called " drunk ".
Presently commercially available awake alcohol product is mostly electuary class, and using the restriction for having occasion, and sober up effect needs one
It can just show after the section time.
The content of the invention
To solve the above problems, sobered up lozenge and preparation method thereof the invention provides one kind, with good shield of relieving the effect of alcohol
Liver effect, and it is good in taste.
To achieve the above object, the technical scheme taken of the present invention is：
One kind is sobered up lozenge, is prepared from by the raw material of following parts by weight：
The careless extract 10-15 of 15-25 parts of black soya bean polypeptide, 10-20 parts of rice protein extract, 30-40 parts of mango juice, Milk Thistle
Part, 3-9 parts of powder of 12-18 parts of trifoliate orange Dulcis freeze-dried powders, green plum enzymolysis, 3-6 parts of bitter chrysanthemum, 5-15 parts of kudzu root extract, Olive leaf P.E
5-10 parts, 8-12 parts of honey, 4-8 parts of maltodextrin.
Preferably, the rice protein extract is alcohol dehydrogenase and acetaldehyde dehydrogenase.
Preferably, the mango juice is as obtained by prepared by following steps：
Mango is cleaned after peeling stoning, handles 3-6 minutes, produces as ultramicro grinding is carried out in micronizer.
Preferably, the careless extract of the Milk Thistle is as obtained by prepared by following steps：
After the careless ultramicro grinding of dry Milk Thistle, add by cellulase：Alkali protease in mass ratio 2:3 mixing gained
Complex enzyme, be combined enzyme dosage be raw material weight 0.7-2.3%, be maintained at 30-45 DEG C and digest 0.5-2h, filter, obtain enzyme
Solve liquid；Enzymolysis liquid is directly by neutral alumina column, and resin column blade diameter length ratio is 1: 5-1: 10, respectively with 1-4 times of cylinder ponding, 1-
3 times of ethanol solutions of column volume 95% elute removal of impurities, with the ethanol (1 of 0.3-0.6% glacial acetic acid -55% of 5-7 times of column volume:1) it is molten
Liquid is eluted, and collects eluent；Fling to after the glacial acetic acid and ethanol in eluent, micro-wave vacuum, obtain the careless extract of Milk Thistle..
Preferably, the kudzu root extract passes through following steps：
Steam explosion in steam-explosion jar is placed in after the root of kudzu vine is cleaned to handle three times, is freeze-dried to obtain kudzu root extract；Wherein, for the first time
It is 0.6-0.9Mpa, 60-90 degrees Celsius of temperature, time 7-23min that explosion treatment, which keeps pressure, and second of explosion treatment keeps pressure
Power is 0.9-1.1Mpa, 90-110 degrees Celsius of temperature, time 0.9-1.3min, and it is 3- that third time explosion treatment, which keeps pressure,
5Mpa, 60-80 degrees Celsius of temperature, time 0.9-2.9min.
Preferably, the green plum enzymolysis powder is as obtained by prepared by following steps：
S1, the green plum that drains will be cleaned it is placed in steam-explosion jar, it is 0.6-1.4MPa to be first passed through nitrogen to steam explosion pressure inside the tank,
Explosion treatment 8-25min；Then it is 1.4-1.8MPa, Steam explosion treatment 0.5- to be passed through steam to steam explosion pressure inside the tank rapidly
After 2.5min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrate, obtains powder；
S2, the 3-8 times of water of addition into powder, are that 2-3% ratio adds neutral proteinase by mass percentage, by quality
Percentage adds at flavor protease, 30-50 DEG C for 1-2% and digests 1-2h, filters, dry that green plum digests powder.
Preferably, the trifoliate orange Dulcis freeze-dried powders are as obtained by prepared by following steps：
S1, the trifoliate orange Dulcis that drains will be cleaned it is placed in steam-explosion jar, it is 0.7-1.7MPa to be first passed through nitrogen to steam explosion pressure inside the tank,
Explosion treatment 7-23min；Then it is 1.7-2.3MPa, Steam explosion treatment 0.9- to be passed through steam to steam explosion pressure inside the tank rapidly
After 2.9min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrate, obtains powder；
S2, the 3-6 times of water of addition into powder, are that 3-5% ratio adds neutral proteinase by mass percentage, by quality
Percentage adds at flavor protease, 30-50 DEG C for 3-6% and digests 1-2h, filters, obtains enzymolysis liquid；
S3, by naturally to thaw again after the zymotic fluid quick freeze of gained, precipitate age of starch in extract；Collect supernatant
Liquid, remainder centrifugation is collected centrifugal liquid and is incorporated in supernatant；
S4, by supernatant with 3-7BV/h flow velocity by macroporous resin column, after Dynamic Adsorption saturation, with deionized water with
The 5-8BV/h above-mentioned macroporous resin column of flow velocity elution is colourless to efflux, then the organic solvent for being 50%-70% with volume fraction
Eluted with 8-12BV/h flow velocity, collected eluent, freeze-drying is obtained trifoliate orange Dulcis freeze-dried powders.
Preferably, the Olive leaf P.E is as obtained by prepared by following steps：
Dry olive leaf is handled with flash extracter, gained extract solution is first heated with high heat, is added after boiling with slow fire
1~1.5h of heat, hollow fiber ultrafiltration membrane filtering；The dregs of a decoction add 15~and 25 times of decoctings boil twice, and hollow fiber ultrafiltration membrane filtering merges
Three filtrates, are concentrated into 1.5g/ml；90~100% organic solvents are slowly added to, until organic solvent concentration is 55~65%,
Refrigeration 8~9 hours, 2000~4000r/min removes supernatant after centrifuging 15~25min, and precipitation is dissolved to original with deionized water
Volume, with organic solvent deposit 2 times, organic solvent concentration is respectively 65~75%, 75~85%；Precipitation deionized water dissolving
To original volume, the solution of trichloroacetic acid of 1/6~1/5 volume 10~12% is added, 4~6h of standing after fully mixing, 2000~
4000r/min goes to precipitate to obtain supernatant after centrifuging 15~25min, and by gained supernatant suction filtration, drying obtains Olive leaf P.E.
Present invention also offers a kind of preparation method for lozenge of sobering up, comprise the following steps：
S1, weigh 15-25 parts of black soya bean polypeptide, 10-20 parts of rice protein extract, 30-40 parts of mango juice, Milk Thistle grass extract
10-15 parts of thing, 12-18 parts of trifoliate orange Dulcis freeze-dried powders, 3-9 parts of powder of green plum enzymolysis, 3-6 parts of bitter chrysanthemum, 5-15 parts of kudzu root extract, olive leaf
5-10 parts of extract, 8-12 parts of honey, 4-8 parts of maltodextrin；
S2, by after the bitter chrysanthemum ultramicro grinding weighed, with the black soya bean polypeptide weighed, rice protein extract, mango juice, Milk Thistle
Careless extract, trifoliate orange Dulcis freeze-dried powders, green plum enzymolysis powder, bitter chrysanthemum, kudzu root extract, Olive leaf P.E, honey and maltodextrin are extremely
In carrying out batch mixing in high speed mixer, mixture is obtained；
S3, by step S2 gained mixture by double screw extruder be blended granulate, screw extruder rotating speed be 600~
900rpm, pressure is 2~3MPa, by melting extrusion, granulation, drying, compression molding.
The invention has the advantages that：
Using black soya bean polypeptide as primary raw material, the careless extract of the homemade mango juice with sobering up and liver protecting functions of collaboration, Milk Thistle,
Trifoliate orange Dulcis freeze-dried powders, green plum enzymolysis powder, kudzu root extract are used cooperatively so that the beverage of gained has good Antialcoholic liver-protecting work(
Can, and it is good in taste, also have effects that to promote appetite, protecting liver and expelling toxin, alleviate and have a headache after drinking, reduce alcohol content in blood,
Simultaneously by the use of alcohol dehydrogenase and acetaldehyde dehydrogenase, the sober-up function of lozenge is substantially increased, and it is harmless to the body, no
Burden of liver can be caused.
Embodiment
In order that objects and advantages of the present invention are more clearly understood, the present invention is carried out with reference to embodiments further
Describe in detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit this hair
It is bright.
In following examples, used organic solvent is the turpentine derivatives of natural origin, and the turpentine oil derives
Thing is the isomery of firpene, disproportionation products；Being for other materials not specified (NS) is commercially available.
Embodiment 1
A kind of preparation method of sobering-up beverage, comprises the following steps：
S1, by mango clean peeling stoning after, as in micronizer carry out ultramicro grinding handle 3-6 minutes, obtain awns
Fruit juice；
S2, by after the careless ultramicro grinding of dry Milk Thistle, add by cellulase：Alkali protease in mass ratio 2:3 mixing
The complex enzyme of gained, is combined the 0.7-2.3% that enzyme dosage is raw material weight, is maintained at 30-45 DEG C and digests 0.5-2h, filter,
Obtain enzymolysis liquid；Enzymolysis liquid is directly by neutral alumina column, and resin column blade diameter length ratio is 1: 5-1: 10, respectively with 1-4 times of column volume
Water, the 1-3 times of ethanol solution of column volume 95% elution removal of impurities, with the ethanol (1 of 0.3-0.6% glacial acetic acid -55% of 5-7 times of column volume:
1) solution is eluted, and collects eluent；Fling to after the glacial acetic acid and ethanol in eluent, micro-wave vacuum, obtain Milk Thistle grass extraction
Thing..
S3, the root of kudzu vine is cleaned after be placed in steam-explosion jar steam explosion and handle three times, be freeze-dried to obtain kudzu root extract；Wherein,
It is 0.6-0.9Mpa, 60-90 degrees Celsius of temperature, time 7-23min that onepull processing, which keeps pressure, and second of explosion treatment is protected
Pressure is held for 0.9-1.1Mpa, 90-110 degrees Celsius of temperature, time 0.9-1.3min, it is 3- that third time explosion treatment, which keeps pressure,
5Mpa, 60-80 degrees Celsius of temperature, time 0.9-2.9min.
S4, the green plum that drains will be cleaned it is placed in steam-explosion jar, it is 0.6-1.4MPa to be first passed through nitrogen to steam explosion pressure inside the tank,
Explosion treatment 8-25min；Then it is 1.4-1.8MPa, Steam explosion treatment 0.5- to be passed through steam to steam explosion pressure inside the tank rapidly
After 2.5min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrate, obtains powder；3-8 times is added into powder
Water, adds neutral proteinase for 2-3% ratio by mass percentage, adds flavor protease by mass percentage for 1-2%,
1-2h is digested at 30-50 DEG C, is filtered, it is dry that green plum digests powder；
S5, the trifoliate orange Dulcis that drains will be cleaned it is placed in steam-explosion jar, it is 0.7-1.7MPa to be first passed through nitrogen to steam explosion pressure inside the tank,
Explosion treatment 7-23min；Then it is 1.7-2.3MPa, Steam explosion treatment 0.9- to be passed through steam to steam explosion pressure inside the tank rapidly
After 2.9min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrate, obtains powder；3-6 times is added into powder
Water, adds neutral proteinase for 3-5% ratio by mass percentage, adds flavor protease by mass percentage for 3-6%,
1-2h is digested at 30-50 DEG C, filters, obtains enzymolysis liquid；Make naturally to thaw again after the zymotic fluid quick freeze of gained in extract
Age of starch is precipitated；Supernatant is collected, remainder centrifugation is collected centrifugal liquid and is incorporated in supernatant；By supernatant with
3-7BV/h flow velocity is by macroporous resin column, after Dynamic Adsorption saturation, above-mentioned with 5-8BV/h flow velocity elution with deionized water
Macroporous resin column is colourless to efflux, then the organic solvent for being 50%-70% with volume fraction is carried out with 8-12BV/h flow velocity
Elution, collects eluent, and freeze-drying obtains trifoliate orange Dulcis freeze-dried powders.
S6, dry olive leaf handled with flash extracter, gained extract solution is first heated with high heat, and slow fire is used after boiling
Heat 1~1.5h, hollow fiber ultrafiltration membrane filtering；The dregs of a decoction add 15~and 25 times of decoctings boil twice, and hollow fiber ultrafiltration membrane filtering is closed
And three filtrates, it is concentrated into 1.5g/ml；Be slowly added to 90~100% organic solvents, until organic solvent concentration be 55~
65%, refrigerate 8~9 hours, 2000~4000r/min removes supernatant, precipitation deionized water dissolving after centrifuging 15~25min
To original volume, with organic solvent deposit 2 times, organic solvent concentration is respectively 65~75%, 75~85%；Precipitation deionized water
Original volume is dissolved to, the solution of trichloroacetic acid of 1/6~1/5 volume 10~12% is added, 4~6h, 2000 are stood after fully mixing
~4000r/min goes to precipitate to obtain supernatant after centrifuging 15~25min, and by gained supernatant suction filtration, drying obtains olive leaf extraction
Thing.
S7, weigh careless 10 parts of the extract of 15 parts of black soya bean polypeptide, 10 parts of rice protein extract, 30 parts of mango juice, Milk Thistle, trifoliate orange
12 parts of Dulcis freeze-dried powders, 3 parts of powder of green plum enzymolysis, 3 parts of bitter chrysanthemum, 5 parts of kudzu root extract, 5 parts of Olive leaf P.E, 8 parts of honey, malt
4 parts of dextrin；
S8, by after the bitter chrysanthemum ultramicro grinding weighed, with the black soya bean polypeptide weighed, rice protein extract, mango juice, Milk Thistle
Careless extract, trifoliate orange Dulcis freeze-dried powders, green plum enzymolysis powder, bitter chrysanthemum, kudzu root extract, Olive leaf P.E, honey and maltodextrin are extremely
In carrying out batch mixing in high speed mixer, mixture is obtained；
S9, by step S8 gained mixture by double screw extruder be blended granulate, screw extruder rotating speed be 600~
900rpm, pressure is 2~3MPa, by melting extrusion, granulation, drying, compression molding.
Embodiment 2
A kind of preparation method of sobering-up beverage, comprises the following steps：
S1, by mango clean peeling stoning after, as in micronizer carry out ultramicro grinding handle 3-6 minutes, obtain awns
Fruit juice；
S2, by after the careless ultramicro grinding of dry Milk Thistle, add by cellulase：Alkali protease in mass ratio 2:3 mixing
The complex enzyme of gained, is combined the 0.7-2.3% that enzyme dosage is raw material weight, is maintained at 30-45 DEG C and digests 0.5-2h, filter,
Obtain enzymolysis liquid；Enzymolysis liquid is directly by neutral alumina column, and resin column blade diameter length ratio is 1: 5-1: 10, respectively with 1-4 times of column volume
Water, the 1-3 times of ethanol solution of column volume 95% elution removal of impurities, with the ethanol (1 of 0.3-0.6% glacial acetic acid -55% of 5-7 times of column volume:
1) solution is eluted, and collects eluent；Fling to after the glacial acetic acid and ethanol in eluent, micro-wave vacuum, obtain Milk Thistle grass extraction
Thing..
S3, the root of kudzu vine is cleaned after be placed in steam-explosion jar steam explosion and handle three times, be freeze-dried to obtain kudzu root extract；Wherein,
It is 0.6-0.9Mpa, 60-90 degrees Celsius of temperature, time 7-23min that onepull processing, which keeps pressure, and second of explosion treatment is protected
Pressure is held for 0.9-1.1Mpa, 90-110 degrees Celsius of temperature, time 0.9-1.3min, it is 3- that third time explosion treatment, which keeps pressure,
5Mpa, 60-80 degrees Celsius of temperature, time 0.9-2.9min.
S4, the green plum that drains will be cleaned it is placed in steam-explosion jar, it is 0.6-1.4MPa to be first passed through nitrogen to steam explosion pressure inside the tank,
Explosion treatment 8-25min；Then it is 1.4-1.8MPa, Steam explosion treatment 0.5- to be passed through steam to steam explosion pressure inside the tank rapidly
After 2.5min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrate, obtains powder；3-8 times is added into powder
Water, adds neutral proteinase for 2-3% ratio by mass percentage, adds flavor protease by mass percentage for 1-2%,
1-2h is digested at 30-50 DEG C, is filtered, it is dry that green plum digests powder；
S5, the trifoliate orange Dulcis that drains will be cleaned it is placed in steam-explosion jar, it is 0.7-1.7MPa to be first passed through nitrogen to steam explosion pressure inside the tank,
Explosion treatment 7-23min；Then it is 1.7-2.3MPa, Steam explosion treatment 0.9- to be passed through steam to steam explosion pressure inside the tank rapidly
After 2.9min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrate, obtains powder；3-6 times is added into powder
Water, adds neutral proteinase for 3-5% ratio by mass percentage, adds flavor protease by mass percentage for 3-6%,
1-2h is digested at 30-50 DEG C, filters, obtains enzymolysis liquid；Make naturally to thaw again after the zymotic fluid quick freeze of gained in extract
Age of starch is precipitated；Supernatant is collected, remainder centrifugation is collected centrifugal liquid and is incorporated in supernatant；By supernatant with
3-7BV/h flow velocity is by macroporous resin column, after Dynamic Adsorption saturation, above-mentioned with 5-8BV/h flow velocity elution with deionized water
Macroporous resin column is colourless to efflux, then the organic solvent for being 50%-70% with volume fraction is carried out with 8-12BV/h flow velocity
Elution, collects eluent, and freeze-drying obtains trifoliate orange Dulcis freeze-dried powders.
S6, dry olive leaf handled with flash extracter, gained extract solution is first heated with high heat, and slow fire is used after boiling
Heat 1~1.5h, hollow fiber ultrafiltration membrane filtering；The dregs of a decoction add 15~and 25 times of decoctings boil twice, and hollow fiber ultrafiltration membrane filtering is closed
And three filtrates, it is concentrated into 1.5g/ml；Be slowly added to 90~100% organic solvents, until organic solvent concentration be 55~
65%, refrigerate 8~9 hours, 2000~4000r/min removes supernatant, precipitation deionized water dissolving after centrifuging 15~25min
To original volume, with organic solvent deposit 2 times, organic solvent concentration is respectively 65~75%, 75~85%；Precipitation deionized water
Original volume is dissolved to, the solution of trichloroacetic acid of 1/6~1/5 volume 10~12% is added, 4~6h, 2000 are stood after fully mixing
~4000r/min goes to precipitate to obtain supernatant after centrifuging 15~25min, and by gained supernatant suction filtration, drying obtains olive leaf extraction
Thing.
S7, weigh careless 15 parts of the extract of 25 parts of black soya bean polypeptide, 20 parts of rice protein extract, 40 parts of mango juice, Milk Thistle, trifoliate orange
18 parts of Dulcis freeze-dried powders, green plum enzymolysis 9 parts of powder, 6 parts of bitter chrysanthemum, 15 parts of kudzu root extract, 10 parts of Olive leaf P.E, 12 parts of honey,
8 parts of maltodextrin；
S8, by after the bitter chrysanthemum ultramicro grinding weighed, with the black soya bean polypeptide weighed, rice protein extract, mango juice, Milk Thistle
Careless extract, trifoliate orange Dulcis freeze-dried powders, green plum enzymolysis powder, bitter chrysanthemum, kudzu root extract, Olive leaf P.E, honey and maltodextrin are extremely
In carrying out batch mixing in high speed mixer, mixture is obtained；
S9, by step S8 gained mixture by double screw extruder be blended granulate, screw extruder rotating speed be 600~
900rpm, pressure is 2~3MPa, by melting extrusion, granulation, drying, compression molding.
Embodiment 3
A kind of preparation method of sobering-up beverage, comprises the following steps：
S1, by mango clean peeling stoning after, as in micronizer carry out ultramicro grinding handle 3-6 minutes, obtain awns
Fruit juice；
S2, by after the careless ultramicro grinding of dry Milk Thistle, add by cellulase：Alkali protease in mass ratio 2:3 mixing
The complex enzyme of gained, is combined the 0.7-2.3% that enzyme dosage is raw material weight, is maintained at 30-45 DEG C and digests 0.5-2h, filter,
Obtain enzymolysis liquid；Enzymolysis liquid is directly by neutral alumina column, and resin column blade diameter length ratio is 1: 5-1: 10, respectively with 1-4 times of column volume
Water, the 1-3 times of ethanol solution of column volume 95% elution removal of impurities, with the ethanol (1 of 0.3-0.6% glacial acetic acid -55% of 5-7 times of column volume:
1) solution is eluted, and collects eluent；Fling to after the glacial acetic acid and ethanol in eluent, micro-wave vacuum, obtain Milk Thistle grass extraction
Thing..
S3, the root of kudzu vine is cleaned after be placed in steam-explosion jar steam explosion and handle three times, be freeze-dried to obtain kudzu root extract；Wherein,
It is 0.6-0.9Mpa, 60-90 degrees Celsius of temperature, time 7-23min that onepull processing, which keeps pressure, and second of explosion treatment is protected
Pressure is held for 0.9-1.1Mpa, 90-110 degrees Celsius of temperature, time 0.9-1.3min, it is 3- that third time explosion treatment, which keeps pressure,
5Mpa, 60-80 degrees Celsius of temperature, time 0.9-2.9min.
S4, the green plum that drains will be cleaned it is placed in steam-explosion jar, it is 0.6-1.4MPa to be first passed through nitrogen to steam explosion pressure inside the tank,
Explosion treatment 8-25min；Then it is 1.4-1.8MPa, Steam explosion treatment 0.5- to be passed through steam to steam explosion pressure inside the tank rapidly
After 2.5min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrate, obtains powder；3-8 times is added into powder
Water, adds neutral proteinase for 2-3% ratio by mass percentage, adds flavor protease by mass percentage for 1-2%,
1-2h is digested at 30-50 DEG C, is filtered, it is dry that green plum digests powder；
S5, the trifoliate orange Dulcis that drains will be cleaned it is placed in steam-explosion jar, it is 0.7-1.7MPa to be first passed through nitrogen to steam explosion pressure inside the tank,
Explosion treatment 7-23min；Then it is 1.7-2.3MPa, Steam explosion treatment 0.9- to be passed through steam to steam explosion pressure inside the tank rapidly
After 2.9min, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrate, obtains powder；3-6 times is added into powder
Water, adds neutral proteinase for 3-5% ratio by mass percentage, adds flavor protease by mass percentage for 3-6%,
1-2h is digested at 30-50 DEG C, filters, obtains enzymolysis liquid；Make naturally to thaw again after the zymotic fluid quick freeze of gained in extract
Age of starch is precipitated；Supernatant is collected, remainder centrifugation is collected centrifugal liquid and is incorporated in supernatant；By supernatant with
3-7BV/h flow velocity is by macroporous resin column, after Dynamic Adsorption saturation, above-mentioned with 5-8BV/h flow velocity elution with deionized water
Macroporous resin column is colourless to efflux, then the organic solvent for being 50%-70% with volume fraction is carried out with 8-12BV/h flow velocity
Elution, collects eluent, and freeze-drying obtains trifoliate orange Dulcis freeze-dried powders.
S6, dry olive leaf handled with flash extracter, gained extract solution is first heated with high heat, and slow fire is used after boiling
Heat 1~1.5h, hollow fiber ultrafiltration membrane filtering；The dregs of a decoction add 15~and 25 times of decoctings boil twice, and hollow fiber ultrafiltration membrane filtering is closed
And three filtrates, it is concentrated into 1.5g/ml；Be slowly added to 90~100% organic solvents, until organic solvent concentration be 55~
65%, refrigerate 8~9 hours, 2000~4000r/min removes supernatant, precipitation deionized water dissolving after centrifuging 15~25min
To original volume, with organic solvent deposit 2 times, organic solvent concentration is respectively 65~75%, 75~85%；Precipitation deionized water
Original volume is dissolved to, the solution of trichloroacetic acid of 1/6~1/5 volume 10~12% is added, 4~6h, 2000 are stood after fully mixing
~4000r/min goes to precipitate to obtain supernatant after centrifuging 15~25min, and by gained supernatant suction filtration, drying obtains olive leaf extraction
Thing.
S7, weigh careless 12.5 parts of the extract of 20 parts of black soya bean polypeptide, 15 parts of rice protein extract, 35 parts of mango juice, Milk Thistle,
15 parts of trifoliate orange Dulcis freeze-dried powders, 6 parts of powder of green plum enzymolysis, 4.5 parts of bitter chrysanthemum, 10 parts of kudzu root extract, 7.5 parts of Olive leaf P.E, honey
10 parts, 6 parts of maltodextrin；
S8, by after the bitter chrysanthemum ultramicro grinding weighed, with the black soya bean polypeptide weighed, rice protein extract, mango juice, Milk Thistle
Careless extract, trifoliate orange Dulcis freeze-dried powders, green plum enzymolysis powder, bitter chrysanthemum, kudzu root extract, Olive leaf P.E, honey and maltodextrin are extremely
In carrying out batch mixing in high speed mixer, mixture is obtained；
S9, by step S8 gained mixture by double screw extruder be blended granulate, screw extruder rotating speed be 600~
900rpm, pressure is 2~3MPa, by melting extrusion, granulation, drying, compression molding.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (9)
- The lozenge 1. one kind is sobered up, it is characterised in that be prepared from by the raw material of following parts by weight：Careless 10-15 parts of the extract of 15-25 parts of black soya bean polypeptide, 10-20 parts of rice protein extract, 30-40 parts of mango juice, Milk Thistle, 12-18 parts of trifoliate orange Dulcis freeze-dried powders, 3-9 parts of powder of green plum enzymolysis, 3-6 parts of bitter chrysanthemum, 5-15 parts of kudzu root extract, Olive leaf P.E 5-10 Part, 8-12 parts of honey, 4-8 parts of maltodextrin.
- The lozenge 2. one kind as claimed in claim 1 is sobered up, it is characterised in that the rice protein extract is alcohol dehydrogenase And acetaldehyde dehydrogenase.
- The lozenge 3. one kind as claimed in claim 1 is sobered up, it is characterised in that the mango juice prepares institute by following steps ：Mango is cleaned after peeling stoning, handles 3-6 minutes, produces as ultramicro grinding is carried out in micronizer.
- The lozenge 4. one kind as claimed in claim 1 is sobered up, it is characterised in that the careless extract of the Milk Thistle passes through following steps system Standby gained：After the careless ultramicro grinding of dry Milk Thistle, add by cellulase：Alkali protease in mass ratio 2:Answering obtained by 3 mixing Synthase, is combined the 0.7-2.3% that enzyme dosage is raw material weight, is maintained at 30-45 DEG C and digests 0.5-2h, filter, obtain enzymolysis liquid； Enzymolysis liquid is directly by neutral alumina column, and resin column blade diameter length ratio is 1: 5-1: 10, respectively with 1-4 times of cylinder ponding, 1-3 times of post The ethanol solution of volume 95% elutes removal of impurities, with the ethanol (1 of 0.3-0.6% glacial acetic acid -55% of 5-7 times of column volume:1) solution is washed It is de-, collect eluent；Fling to after the glacial acetic acid and ethanol in eluent, micro-wave vacuum, obtain the careless extract of Milk Thistle..
- The lozenge 5. one kind as claimed in claim 1 is sobered up, it is characterised in that the kudzu root extract passes through following steps：Steam explosion in steam-explosion jar is placed in after the root of kudzu vine is cleaned to handle three times, is freeze-dried to obtain kudzu root extract；Wherein, the first separate explosion It is 0.6-0.9Mpa, 60-90 degrees Celsius of temperature, time 7-23min that processing, which keeps pressure, and second of explosion treatment holding pressure is 0.9-1.1Mpa, 90-110 degrees Celsius of temperature, time 0.9-1.3min, it is 3-5Mpa, temperature that third time explosion treatment, which keeps pressure, Spend 60-80 degrees Celsius, time 0.9-2.9min.
- The lozenge 6. one kind as claimed in claim 1 is sobered up, it is characterised in that the green plum enzymolysis powder is prepared by following steps Gained：S1, the green plum that drains will be cleaned it is placed in steam-explosion jar, it is 0.6-1.4MPa, explosion to be first passed through nitrogen to steam explosion pressure inside the tank Handle 8-25min；Then it is 1.4-1.8MPa, Steam explosion treatment 0.5-2.5min to be passed through steam to steam explosion pressure inside the tank rapidly Afterwards, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrate, obtains powder；S2, the 3-8 times of water of addition into powder, are that 2-3% ratio adds neutral proteinase by mass percentage, by quality percentage 1-2h is digested than being added for 1-2% at flavor protease, 30-50 DEG C, is filtered, it is dry that green plum digests powder.
- The lozenge 7. one kind as claimed in claim 1 is sobered up, it is characterised in that the trifoliate orange Dulcis freeze-dried powders are prepared by following steps Gained：S1, the trifoliate orange Dulcis that drains will be cleaned it is placed in steam-explosion jar, it is 0.7-1.7MPa, explosion to be first passed through nitrogen to steam explosion pressure inside the tank Handle 7-23min；Then it is 1.7-2.3MPa, Steam explosion treatment 0.9-2.9min to be passed through steam to steam explosion pressure inside the tank rapidly Afterwards, room temperature is concentrated into relative density 1.10-1.20, is spray-dried concentrate, obtains powder；S2, the 3-6 times of water of addition into powder, are that 3-5% ratio adds neutral proteinase by mass percentage, by quality percentage 1-2h is digested than being added for 3-6% at flavor protease, 30-50 DEG C, filters, obtains enzymolysis liquid；S3, by naturally to thaw again after the zymotic fluid quick freeze of gained, precipitate age of starch in extract；Collect supernatant, Remainder is centrifuged, and is collected centrifugal liquid and is incorporated in supernatant；S4, by supernatant with 3-7BV/h flow velocity by macroporous resin column, after Dynamic Adsorption saturation, with deionized water with 5- It is colourless to efflux that 8BV/h flow velocity elutes above-mentioned macroporous resin column, then the organic solvent for being 50%-70% with volume fraction with 8-12BV/h flow velocity is eluted, and collects eluent, and freeze-drying obtains trifoliate orange Dulcis freeze-dried powders.
- The lozenge 8. one kind as claimed in claim 1 is sobered up, it is characterised in that the Olive leaf P.E passes through following steps system Standby gained：Dry olive leaf is handled with flash extracter, gained extract solution is first heated with high heat, 1 is heated with slow fire after boiling ~1.5h, hollow fiber ultrafiltration membrane filtering；The dregs of a decoction add 15~and 25 times of decoctings boil twice, and hollow fiber ultrafiltration membrane filtering merges three Secondary filtrate, is concentrated into 1.5g/ml；90~100% organic solvents are slowly added to, until organic solvent concentration is 55~65%, it is cold Hide 8~9 hours, 2000~4000r/min removes supernatant after centrifuging 15~25min, and precipitation is dissolved to substance with deionized water Product, with organic solvent deposit 2 times, organic solvent concentration is respectively 65~75%, 75~85%；Precipitation is dissolved to deionized water Original volume, adds the solution of trichloroacetic acid of 1/6~1/5 volume 10~12%, 4~6h of standing after fully mixing, 2000~ 4000r/min goes to precipitate to obtain supernatant after centrifuging 15~25min, and by gained supernatant suction filtration, drying obtains Olive leaf P.E.
- 9. a kind of preparation method for lozenge of sobering up, it is characterised in that comprise the following steps：S1, weigh the careless extract of 15-25 parts of black soya bean polypeptide, 10-20 parts of rice protein extract, 30-40 parts of mango juice, Milk Thistle 10-15 parts, 12-18 parts of trifoliate orange Dulcis freeze-dried powders, 3-9 parts of powder of green plum enzymolysis, 3-6 parts of bitter chrysanthemum, 5-15 parts of kudzu root extract, olive leaf carry Take 5-10 parts of thing, 8-12 parts of honey, 4-8 parts of maltodextrin；S2, by after the bitter chrysanthemum ultramicro grinding weighed, carried with the black soya bean polypeptide weighed, rice protein extract, mango juice, Milk Thistle grass Thing, trifoliate orange Dulcis freeze-dried powders, green plum enzymolysis powder, bitter chrysanthemum, kudzu root extract, Olive leaf P.E, honey and maltodextrin are taken as height Batch mixing is carried out in fast batch mixer, mixture is obtained；S3, by step S2 gained mixture by double screw extruder be blended granulate, screw extruder rotating speed be 600~ 900rpm, pressure is 2~3MPa, by melting extrusion, granulation, drying, compression molding.
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| CN108310309A (en) * | 2018-04-27 | 2018-07-24 | 江苏护理职业学院 | A kind of inducing resuscitation sachet and preparation method thereof |
| CN108376559A (en) * | 2018-02-28 | 2018-08-07 | 复旦大学附属中山医院 | Application of the aldehyde dehydrogenase 2 genotype in anaesthesia dosage calculating |
| WO2019140479A1 (en) * | 2018-01-19 | 2019-07-25 | Clever Health Pty Ltd | Compositions and methods for the prophylaxis or treatment of a condition associated with alcohol consumption |
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