CN106334046A - Traditional Chinese medicine composition for treating rhinitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating rhinitis and preparation method thereof Download PDFInfo
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- CN106334046A CN106334046A CN201610878556.XA CN201610878556A CN106334046A CN 106334046 A CN106334046 A CN 106334046A CN 201610878556 A CN201610878556 A CN 201610878556A CN 106334046 A CN106334046 A CN 106334046A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating rhinitis. The traditional Chinese medicine composition comprises tetrastigma lenticellatum, alocasia macrorrhiza, chrysanthemum nankingense, loofah, iris dichotoma, asarum herb, cassia seed, gray vernonia, magnolia delavayi flower, beehive and radix astragali. According to the traditional Chinese medicine composition, the raw materials are selected, the compatibility is reasonable, effects are complementary, and a good synergistic effect can be achieved. The traditional Chinese medicine composition can treat both symptoms and root causes of various acute and chronic rhinitis, the rhinitis does not occur again after being cured, a curative effect is consolidated, and the total effective rate can reach 96% or above. The traditional Chinese medicine composition is safe and becomes effective quickly, a patient's pain is small, no medicine resistance is generated, the traditional Chinese medicine composition is small in toxic and side effects and low in treatment cost and is easily accepted by patients, and the shortcoming that toxic and side effects are generated due to a large dose of western medicines is overcome. The reappearing probability of the rhinitis is reduced.
Description
Technical field
The present invention relates to a kind of medicinal preparation, more particularly, to a kind of Chinese medicine composition for treating rhinitis and its preparation
Method.
Background technology
Rhinitis is divided into acute rhinitis and rhinitis chronic, and rhinitis chronic includes chronic simple rhinitis and chronic hypertrophic nose again
Scorching.Chronic simple rhinitis shows as nasal decongestion, swelling, takes on a red color or kermesinus, with intermittence, alternately has a stuffy nose, nose
Tears amount mostly is cardinal symptom；Chronic hypertrophic rhinitis heavier, the mostly continuation of nasal obstruction, has rhinolalia clausa, hyposphresia, nasal mucus
For mucus or glutinous purulence, it is difficult to blow out, how with headache, dizzy, insomnia and the symptom such as One's spirits are drooping.The chronic nose of both the above
The scorching general course of disease is longer, exacerbation of symptoms after fatigue, sense are cold, the easily concurrent disease such as ear is swollen, ear closes.Acute rhinitis is had a stuffy nose also known as cold,
With nasal obstruction, sneeze, clear tears as cardinal symptom, checked by nasal cavity, show as nasal decongestion, nasal cavity endocrine increases, rise
Disease is more anxious, and the course of disease is shorter.
The medicine of clinical treatment rhinitis has Western medicine and Chinese medicine at present, and in Western medicine, great majority are oral medicine or aqua nose drops,
Aqua nose drops easily flow, and are difficult to be attached on nasal membrane, action time is short, easily recurs after drug withdrawal, and Long-Time Service is easily caused
Vasomotor rhinitis；It is added with hormone oral drugs Chinese and Western medicine although curative effect is fast more, but easily repeatedly, Long-Time Service is also easy to produce
The resistance to the action of a drug, the large side effects to human body.
Content of the invention
In order to solve the above problems, the present invention provides that a kind of prescription safety, instant effect, patient suffering is little, not anti-medicine, poison are secondary
Effect is little, medical expense is low, be easily accepted by patients, avoid heavy dose of defect, minimizing nose producing toxic and side effect using Western medicine
The Chinese medicine composition of the scorching treatment rhinitis of recurrence probability.
The technical solution used in the present invention is: a kind of Chinese medicine for treating rhinitis composition, each group of described Chinese medicine composition
Part for great Wu pawl gold dragon, Alocasia ordora, chrysanthemum brain, sponge gourd brain, flat cattail leaf fan, the root of Chinese wild ginger, cassia seed, typhoid fever grass, magnolia delavayi flower, honeybee room,
The Radix Astragali.
Preferably, the ratio of weight and number of various components is great Wu pawl gold dragon 25-35 part, Alocasia ordora 15-25 part, chrysanthemum brain 15-
25 parts, sponge gourd brain 10-20 part, flat cattail leaf fan 10-20 part, root of Chinese wild ginger 5-15 part, cassia seed 5-15 part, typhoid fever grass 5-15 part, magnolia delavayi
Flower 5-15 part, honeybee room 5-15 part, Radix Astragali 5-15 part.
It is furthermore preferred that the ratio of weight and number of various components is great Wu pawl gold dragon 30-35 part, Alocasia ordora 20-25 part, chrysanthemum brain
20-25 part, sponge gourd brain 10-15 part, flat cattail leaf fan 10-15 part, root of Chinese wild ginger 5-10 part, cassia seed 5-10 part, typhoid fever grass 5-10 part, mountain are beautiful
Orchid 5-10 part, honeybee room 5-10 part, Radix Astragali 5-10 part.
Wherein, the formulation of described Chinese medicine composition is: film coated tablet, sublimed preparation, emplastrum, syrup, oral liquid, mouth containing
Agent, granule, powder, injection, sugar coated tablet, capsule.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the formulation of described Chinese medicine is capsule, bag
Include:
The first step, Alocasia ordora, chrysanthemum brain mix in proportion, are 70-80% with the determining alcohol being equivalent to 2-3 times of mixture quality
Normal propyl alcohol refluxing extraction 2-4 time, merging filtrate, reduced pressure concentration, drying are simultaneously ground into powder, subsequently use ethyl alcohol purification 1-2 time,
Merge extract, decompression recycling ethanol is simultaneously concentrated into the lotion for 1.21-1.24 for the relative density at 60 DEG C, is dried and is ground into powder
End；
Second step, the normal propyl alcohol that sponge gourd brain, flat cattail leaf fan, the root of Chinese wild ginger, cassia seed determining alcohol are 80-90% is extracted 2-3 time,
Merge extract, reduced pressure concentration is simultaneously dried, is ground into powder, it is 2-4 that the powder after pulverizing is added with respect to its quality
The water dissolves of times amount, static 1-3 hour, filter, filtrate reduced in volume be at 60 DEG C relative density be 1.21-1.24 lotion simultaneously
Dry, pulverize into powder；
3rd step, remaining component is ground into powder and mixes in proportion, adds water to cook 2 times, and each 2-3 hour filters respectively,
Merging filtrate, filtrate is condensed into lotion and dry, pulverize into powder, and the quality of the water being added is the mixture quality of the 3rd step
2-4 times；
4th step, above-mentioned powder and starch mixing subsequently carry out pelletization treatment and are dried, obtain compound particles, then
Magnesium stearate, described magnesium stearate and described compound particles mass ratio is added to be 0.25-100 in compound particles:
0.5-100, obtains capsule 's content, described capsule 's content is loaded in capsule housing and obtains final product capsule.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the formulation of described Chinese medicine is injection, bag
Include:
The first step, Alocasia ordora, chrysanthemum brain mix in proportion, are 70-80% with the determining alcohol being equivalent to 2-3 times of mixture quality
Normal propyl alcohol refluxing extraction 2-4 time, merging filtrate, reduced pressure concentration, drying are simultaneously ground into powder, subsequently use ethyl alcohol purification 1-2 time,
Merge extract, decompression recycling ethanol is simultaneously concentrated into the lotion for 1.21-1.24 for the relative density at 60 DEG C, is dried and is ground into powder
End；
Second step, the normal propyl alcohol that sponge gourd brain, flat cattail leaf fan, the root of Chinese wild ginger, cassia seed determining alcohol are 80-90% is extracted 2-3 time,
Merge extract, reduced pressure concentration is simultaneously dried, is ground into powder, it is 2-4 that the powder after pulverizing is added with respect to its quality
The water dissolves of times amount, static 1-3 hour, filter, filtrate reduced in volume be at 60 DEG C relative density be 1.21-1.24 lotion simultaneously
Dry, pulverize into powder；
3rd step, remaining component is ground into powder and mixes in proportion, adds water to cook 2 times, and each 2-3 hour filters respectively,
Merging filtrate, filtrate is condensed into lotion and dry, pulverize into powder, and the quality of the water being added is the mixture quality of the 3rd step
2-4 times；
4th step, above-mentioned powder is mixed, and is subsequently dissolved in the water that quality is 2-4 times of mixture, and stirring is lower to add phase
For the NaOH hydrotropy of powder quality 5%-15%, filter, plus the hydrochloric acid regulation ph value that concentration is 1mol/l is 5-6, mistake
Filter, precipitation is standby, and filtrate passes through polyamide column, first washes decontamination with water, is subsequently washed with the normal propyl alcohol that determining alcohol is 80-90%
De-, collect normal propyl alcohol eluent, precipitation determining alcohol is that the normal propyl alcohol of 80-90% extracts 2 times, filtration, filtrate and above-mentioned wash-out
Liquid merges, and reclaims normal propyl alcohol, is evaporated to lotion and is spray dried to powder, the powder of acquisition is added with respect to its quality 1-
2 times of sodium chloride and appropriate water for injection, further inject water to the volume of needs after dissolving, filter, embedding, go out
Bacterium, obtains the parenteral solution needing.
Great Wu pawl gold dragon, taste is pungent is bitter, warm in nature, wind-dispelling, promoting blood circulation, detumescence.Fengshi Guanjie pain, stomatitis, rhinitis；External application is controlled
Traumatic injury, fracture.
Alocasia ordora, taste micro-pungent, puckery, cold in nature, poisonous, clearing heat and detoxicating, detumescence, for catching a cold, pulmonary tuberculosis, parenteral cold.
Chrysanthemum brain, bitter, pungent, cool in nature, clearing heat and detoxicating.Main air fire cute conjunctivitis；Rhinitis；Abscess of throat；Bronchitis；Boil swells
Bitterly.
Sponge gourd brain, sweet, mild-natured, clearing heat and detoxicating.For rhinitis, paranasal sinusitis.
The root of Chinese wild ginger, taste is pungent, temperature, the thoughts of returning home, lung, kidney channel, expelling wind and clearing away cold, sensible pain relieving, Wenfei of drink.For anemofrigid cold, head
Bitterly, have a toothache, nasosinusitis of having a stuffy nose, arthralgia due to wind-dampness, phlegm and retained fluid is breathed with cough.
Flat cattail leaf fan, bitter, cold, slightly poisonous, clearing heat and detoxicating, activating blood circulation and reducing swelling.Cure mainly abscess of throat, tonsillitis, hepatitis, liver
Enlargement, stomachache, mastitis.
Cassia seed, sweet, bitter, salty, it is slightly cold, Return liver, large intestine channel, heat-clearing improving eyesight, relax bowel.For the puckery pain of hot eyes, shy
Bright many tear, dizziness of having a headache, mesh is secretly failed to understand, constipation.
Typhoid fever grass, cool in nature, lightly seasoned, heat-clearing, dehumidifying, removing toxic substances.Control fever caused by exogenous pathogens, acute icteric hepatitis, damp-heat diarrhea, malignant boil
Pyogenic infections from tumour or sore.
Magnolia delavayi is spent, bitter, pungent, mild-natured, a surname's lung cough-relieving.For rhinitis, nasosinusitis, bronchitis, cough.
Honeybee room, taste micro-sweet, cool in nature, removing toxicity for detumescence；Wind dispelling insecticide.Main sore and toxic；Pharyngalgia is coughed；Rhinitis chronic；Nose
Sinusitis；Eczema itch；Sore tinea.
The Radix Astragali, sweet, warm in nature, return lung, the spleen channel, invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.Weary for the deficiency of vital energy
Power, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, bursts for a long time and does not holds back, blood
Empty impotence is yellow, Heat Diabetes.
Beneficial effects of the present invention:
With respect to the medicine with treatment rhinitis effect of the prior art, selected raw material of the present invention, compatibility is reasonable, effect
Complementation, can produce preferable synergy.This medicine can be treated both principal and secondary aspect of disease to various acute rhinitis chronics, does not rebound after healing, curative effect
Consolidate, total effective rate is up to more than 96%；This Chinese prescription safety, instant effect, patient suffering is little, not anti-medicine, and toxic and side effect is little,
Medical expense is low, is easily accepted by patients, it is to avoid heavy dose of use Western medicine produces the defect of toxic and side effect.Reduce the recurrence of rhinitis
Probability.
Specific embodiment
Embodiment 1:
(1) a kind of Chinese medicine for treating rhinitis, is formed by following raw material medicaments in part by weight proportioning:
30 parts of great Wu pawl gold dragon, 25 parts of Alocasia ordora, 20 parts of chrysanthemum brain, 15 parts of sponge gourd brain, 15 parts of flat cattail leaf fan, 10 parts of the root of Chinese wild ginger, certainly
10 parts of pine torch, typhoid fever grass 10 parts, magnolia delavayi spend 10 parts, 5 parts of honeybee room, 5 parts of the Radix Astragali.
(2) preparation method:
The first step, Alocasia ordora, chrysanthemum brain mix in proportion, are 70% just with the determining alcohol being equivalent to 2 times of mixture quality
Propyl alcohol refluxing extraction 2 times, merging filtrate, reduced pressure concentration, drying are simultaneously ground into powder, subsequently use ethyl alcohol purification 1-2 time, merging carries
Take liquid, decompression recycling ethanol is simultaneously concentrated into the lotion for 1.21-1.24 for the relative density at 60 DEG C, is dried and is ground into powder；
Second step, the normal propyl alcohol that sponge gourd brain, flat cattail leaf fan, the root of Chinese wild ginger, cassia seed determining alcohol are 80-90% is extracted 2-3 time,
Merge extract, reduced pressure concentration is simultaneously dried, is ground into powder, the powder after pulverizing is added and is 2 times with respect to its quality
The water dissolves of amount, static 1 hour, filter, and filtrate reduced in volume is that at 60 DEG C, relative density is the lotion of 1.21-1.24 and does
Dry, it is ground into powder；
3rd step, remaining component is ground into powder and mixes in proportion, adds water to cook 2 times, 2 hours every time, filters respectively, closes
And filtrate, filtrate is condensed into lotion and dry, pulverize into powder, and the quality of the water being added is the mixture quality of the 3rd step
2 times；
4th step, above-mentioned powder and starch mixing subsequently carry out pelletization treatment and are dried, obtain compound particles, then
Add magnesium stearate, described magnesium stearate and described compound particles mass ratio to be 0.25:0.5 in compound particles, obtain
Obtain capsule 's content, in capsule 's content loading capsule housing that will be described, obtain final product capsule.
Embodiment 2:
(1) a kind of Chinese medicine for treating rhinitis, is formed by following raw material medicaments in part by weight proportioning: with embodiment 1.
(2) preparation method:
The first step, Alocasia ordora, chrysanthemum brain mix in proportion, are 70% just with the determining alcohol being equivalent to 2 times of mixture quality
Propyl alcohol refluxing extraction 2 times, merging filtrate, reduced pressure concentration, drying are simultaneously ground into powder, subsequently use ethyl alcohol purification 1 time, merge and extract
Liquid, decompression recycling ethanol is simultaneously concentrated into the lotion for 1.21-1.24 for the relative density at 60 DEG C, is dried and is ground into powder；
Second step, the normal propyl alcohol that sponge gourd brain, flat cattail leaf fan, the root of Chinese wild ginger, cassia seed determining alcohol are 80% is extracted 2 times, merges
Extract, reduced pressure concentration is simultaneously dried, is ground into powder, and it is 2 times amount that the powder after pulverizing is added with respect to its quality
Water dissolves, static 1 hour, filter, and filtrate reduced in volume is that at 60 DEG C, relative density is the lotion of 1.21-1.24 and is dried, powder
It is broken into powder；
3rd step, remaining component is ground into powder and mixes in proportion, adds water to cook 2 times, 2 hours every time, filters respectively, closes
And filtrate, filtrate is condensed into lotion and dry, pulverize into powder, and the quality of the water being added is the mixture quality of the 3rd step
2 times；
4th step, above-mentioned powder is mixed, and is subsequently dissolved in the water that quality is 2 times of mixture, and stirring is lower to be added relatively
In the NaOH hydrotropy of powder quality 5%, filter, plus the hydrochloric acid regulation ph value that concentration is 1mol/l is 5-6, filters, precipitation
Standby, filtrate passes through polyamide column, first washes decontamination with water, the normal propyl alcohol wash-out being subsequently 80 with determining alcohol, collects normal propyl alcohol
Eluent, precipitation determining alcohol is that 80 normal propyl alcohol extracts 2 times, filters, filtrate merges with above-mentioned eluent, recovery normal propyl alcohol,
It is evaporated to lotion and is spray dried to powder, the powder of acquisition is added sodium chloride and the injection with respect to 2 times of its quality
Appropriate amount of water, further injects water to the volume of needs after dissolving, filter, embedding, and sterilizing obtains the parenteral solution needing.
Embodiment 3:
1st, long term toxicity test process:
Experimental agents are set as by application wistar rat (Beijing Vital River Experimental Animals Technology Co., Ltd.'s offer)
Capsule 8g/kg, 4g/kg, 2g/kg of high, medium and low three dosage, respectively embodiment 1 formula.Use dosage 0.1g/ by people
Kg/ sky-backing calculates, and is 80 times, 40 times and 20 times of people's effective dose respectively；Separately set a control group, continuous gavage administration 90
My god, after 180 days and Some Animals are discontinued 10 days, observe the impact to rat items physiology, biochemical indicator.Test result indicate that:
With various dose to rat continuous oral 180 days, the food-intake and body weight increase of rat is all no affected.To hepatic and renal function all not
Find overt toxicity effect.Routine blood test, blood biochemistry, urine biochemistry and marrow piece etc. are showed no and significantly affect, between each group with right
Compare no significant difference according to group.
2nd, acute toxicity test process:
Application icr mouse (Beijing Vital River Experimental Animals Technology Co., Ltd.'s offer) 40, body weight at 25-30 gram,
Carry out acute toxicity testing.Mouse is randomly divided into two groups, i.e. control group, administration group, fasting 12 hours before experiment, then give as
Chinese medicine capsules suspension (capsule the is dissolved in water acquisition suspension) gavage of the present invention that embodiment 1 prepares,
Median lethal dose (ld to administration50) carry out test mensure, but do not measure ld50, therefore carried out mtd test.
Result: with Cmax (60%), maximum dosage-feeding (120ml/kg, in a day, part gives for four times) 100g/kg gavage, be equivalent to
Crude drug amount 60g/kg, is equivalent to clinical 300 times (by the 75kg) intending daily dosage of adult, none dead, execution of mouse in seven days
The each internal organs of mouse anatomic observation do not find toxic reaction, administration group and the no any difference of control group mice.
Embodiment 4:
The clinical treatment observation of the present invention is as follows:
(1) Patients with 300 Cases, wherein 150 be women, 150 be the male sex.
(2) diagnostic criteria:
Diagnostic criteria: " tcm internal medicine disease Standardization of diagnosis and curative effect " determines diagnostic criteria:
1st, with nasal obstruction, sneeze, stream clear water sample or mucus nasal mucus as cardinal symptom, with aversion to cold, heating, headache；
2nd, nasal cavity inspection: nasal decongestion, concha enlargement, nasal cavity endocrine increases.
(3) treatment method: 1 group: using the capsule 100g being obtained as embodiment 1 preparation method, be divided into 10 parts, daily
Morning administered at empty stomach is a, and 30 days is a course for the treatment of, continuously takes two courses for the treatment of；2 groups: using as embodiment 2 preparation method system
The capsule 100g obtaining, is divided into 10 parts, and every morning, administered at empty stomach was a, and 30 days is a course for the treatment of, continuously takes two courses for the treatment of；
Separately set a control group.
(4) efficacy assessment standard:
Criterion of therapeutical effect:
Overall efficacy evaluation is with reference to " new Chinese medicine guideline of clinical investigations " relevant criterion:
Cure: whole body and local symptom and sign disappear；
Effective: whole body and local symptom and sign have clear improvement or have improvement；
Invalid: symptom and sign are not improved.
(5) treatment results are shown in Table 1:
Table 1 treatment results
| Group | Recovery from illness | Effectively | Invalid |
| Control group | 0 | 1 | 99 |
| 1 group | 86 | 12 | 2 |
| 2 groups | 89 | 10 | 1 |
Above-described embodiment simply to illustrate that the technology design of the present invention and feature, its objective is to be to allow in the art
Those of ordinary skill will appreciate that present disclosure and implements according to this, can not be limited the scope of the invention with this.All
It is equivalent change or the modification according to done by the essence of present invention, all should cover in protection scope of the present invention.
Claims (6)
1. a kind of Chinese medicine for treating rhinitis composition it is characterised in that: each component of described Chinese medicine composition be great Wu pawl gold dragon,
Alocasia ordora, chrysanthemum brain, sponge gourd brain, flat cattail leaf fan, the root of Chinese wild ginger, cassia seed, typhoid fever grass, magnolia delavayi flower, honeybee room, the Radix Astragali..
2. Chinese medicine composition as claimed in claim 1 it is characterised in that: the ratio of weight and number of various components be great Wu pawl gold dragon
25-35 part, Alocasia ordora 15-25 part, chrysanthemum brain 15-25 part, sponge gourd brain 10-20 part, flat cattail leaf fan 10-20 part, root of Chinese wild ginger 5-15 part, Cassia
Sub- 5-15 part, typhoid fever grass 5-15 part, magnolia delavayi spend 5-15 part, honeybee room 5-15 part, Radix Astragali 5-15 part.
3. Chinese medicine composition as claimed in claim 1 it is characterised in that: the ratio of weight and number of various components be great Wu pawl gold dragon
30-35 part, Alocasia ordora 20-25 part, chrysanthemum brain 20-25 part, sponge gourd brain 10-15 part, flat cattail leaf fan 10-15 part, root of Chinese wild ginger 5-10 part, Cassia
Sub- 5-10 part, typhoid fever grass 5-10 part, magnolia delavayi spend 5-10 part, honeybee room 5-10 part, Radix Astragali 5-10 part.
4. treat the Chinese medicine composition of rhinitis as any one of claim 1-3 it is characterised in that described Chinese medicine composition
Formulation be: film coated tablet, sublimed preparation, emplastrum, syrup, oral liquid, mouth containing agent, granule, powder, injection, sugar-coat
Tablet, capsule.
5. a kind of as any one of claim 1-3 treat rhinitis Chinese medicine composition preparation method it is characterised in that:
When the formulation of described Chinese medicine is capsule, comprising:
The first step, Alocasia ordora, chrysanthemum brain mix in proportion, with the determining alcohol being equivalent to 2-3 times of mixture quality be 70-80% just
Propyl alcohol refluxing extraction 2-4 time, merging filtrate, reduced pressure concentration, drying are simultaneously ground into powder, subsequently use ethyl alcohol purification 1-2 time, merging
Extract, decompression recycling ethanol is simultaneously concentrated into the lotion for 1.21-1.24 for the relative density at 60 DEG C, is dried and is ground into powder；
Second step, the normal propyl alcohol that sponge gourd brain, flat cattail leaf fan, the root of Chinese wild ginger, cassia seed determining alcohol are 80-90% is extracted 2-3 time, merging
Extract, reduced pressure concentration is simultaneously dried, is ground into powder, and it is 2-4 times amount that the powder after pulverizing is added with respect to its quality
Water dissolves, static 1-3 hour, filter, filtrate reduced in volume is that at 60 DEG C, relative density is the lotion of 1.21-1.24 and does
Dry, it is ground into powder；
3rd step, remaining component is ground into powder and mixes in proportion, adds water to cook 2 times, and each 2-3 hour filters respectively, merges
Filtrate, filtrate is condensed into lotion and dry, pulverize into powder, and the quality of the water being added is the 2- of the mixture quality of the 3rd step
4 times；
4th step, by above-mentioned powder and starch mixing, subsequently carry out pelletization treatment and be dried, obtain compound particles, then to mix
Magnesium stearate, described magnesium stearate and described compound particles mass ratio is added to be 0.25-100:0.5- in polymer beads
100, obtain capsule 's content, described capsule 's content is loaded in capsule housing and obtains final product capsule.
6. a kind of as any one of claim 1-3 treat rhinitis Chinese medicine composition preparation method it is characterised in that:
When the formulation of described Chinese medicine is injection, comprising:
The first step, Alocasia ordora, chrysanthemum brain mix in proportion, with the determining alcohol being equivalent to 2-3 times of mixture quality be 70-80% just
Propyl alcohol refluxing extraction 2-4 time, merging filtrate, reduced pressure concentration, drying are simultaneously ground into powder, subsequently use ethyl alcohol purification 1-2 time, merging
Extract, decompression recycling ethanol is simultaneously concentrated into the lotion for 1.21-1.24 for the relative density at 60 DEG C, is dried and is ground into powder；
Second step, the normal propyl alcohol that sponge gourd brain, flat cattail leaf fan, the root of Chinese wild ginger, cassia seed determining alcohol are 80-90% is extracted 2-3 time, merging
Extract, reduced pressure concentration is simultaneously dried, is ground into powder, and it is 2-4 times amount that the powder after pulverizing is added with respect to its quality
Water dissolves, static 1-3 hour, filter, filtrate reduced in volume is that at 60 DEG C, relative density is the lotion of 1.21-1.24 and does
Dry, it is ground into powder；
3rd step, remaining component is ground into powder and mixes in proportion, adds water to cook 2 times, and each 2-3 hour filters respectively, merges
Filtrate, filtrate is condensed into lotion and dry, pulverize into powder, and the quality of the water being added is the 2- of the mixture quality of the 3rd step
4 times；
4th step, above-mentioned powder is mixed, and is subsequently dissolved in the water that quality is 2-4 times of mixture, the lower addition of stirring with respect to
The NaOH hydrotropy of powder quality 5%-15%, filters, plus the hydrochloric acid regulation ph value that concentration is 1mol/l is 5-6, filters, sinks
Form sediment standby, filtrate passes through polyamide column, first washes decontamination with water, the normal propyl alcohol wash-out being subsequently 80-90% with determining alcohol, collect
Normal propyl alcohol eluent, precipitation determining alcohol is that the normal propyl alcohol of 80-90% extracts 2 times, filters, filtrate is merged with above-mentioned eluent,
Reclaim normal propyl alcohol, be evaporated to lotion and be spray dried to powder, the powder of acquisition is added the chlorine with respect to its quality 1-2 times
Change sodium and appropriate water for injection, after dissolving, further inject water to the volume of needs, filter, embedding, sterilizing, obtain and need
The parenteral solution wanted.
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| CN1377665A (en) * | 2001-03-29 | 2002-11-06 | 白金龙 | Decoction for treating nose and throat diseases |
| CN104906440A (en) * | 2015-06-28 | 2015-09-16 | 谢新刚 | Traditional Chinese medicine for acute nasopharyngitis treatment |
| CN105727144A (en) * | 2016-04-03 | 2016-07-06 | 张鸿 | Traditional Chinese medicine composition for treating bronchitis and preparation method thereof |
| CN105749181A (en) * | 2016-04-29 | 2016-07-13 | 郇述玲 | Traditional Chinese medicine composition for treating fatty liver and preparation method of traditional Chinese medicine composition |
| CN105920349A (en) * | 2016-06-22 | 2016-09-07 | 练燕华 | Traditional Chinese medicament for treating rhinitis |
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