CN106310293A - 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用 - Google Patents

在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用 Download PDF

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Publication number
CN106310293A
CN106310293A CN201610656942.4A CN201610656942A CN106310293A CN 106310293 A CN106310293 A CN 106310293A CN 201610656942 A CN201610656942 A CN 201610656942A CN 106310293 A CN106310293 A CN 106310293A
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liposome
application
carrier
compositions
polynucleotide
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CN201610656942.4A
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Chinese (zh)
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M·曼斯奥
M·卡尔卡达
G·M·韦尔
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Immunovaccine Technologies Inc
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Immunovaccine Technologies Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
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  • Proteomics, Peptides & Aminoacids (AREA)
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CN201610656942.4A 2007-09-27 2008-09-24 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用 Pending CN106310293A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97560207P 2007-09-27 2007-09-27
US60/975,602 2007-09-27
US6130308P 2008-06-13 2008-06-13
US61/061,303 2008-06-13
CN200880108975A CN101827613A (zh) 2007-09-27 2008-09-24 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用

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CN106310293A true CN106310293A (zh) 2017-01-11

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CN201610656942.4A Pending CN106310293A (zh) 2007-09-27 2008-09-24 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用
CN200880108975A Pending CN101827613A (zh) 2007-09-27 2008-09-24 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用

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US (4) US9498493B2 (enExample)
EP (1) EP2197497B1 (enExample)
JP (2) JP5731198B2 (enExample)
CN (2) CN106310293A (enExample)
AU (1) AU2008303023B2 (enExample)
CA (1) CA2700808C (enExample)
ES (1) ES2588705T3 (enExample)
WO (1) WO2009039628A1 (enExample)

Cited By (1)

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CN114727957A (zh) * 2019-10-16 2022-07-08 免疫疫苗技术公司 用于递送活性剂或治疗剂的水包油乳剂制剂

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CN104263756A (zh) * 2014-09-29 2015-01-07 大连理工大学 一种非病毒基因载体的制备方法
CN107531736B (zh) 2015-01-06 2022-04-15 免疫疫苗科技公司 脂质a模拟物、其制备方法和用途
JP6989134B2 (ja) 2015-11-18 2022-01-05 イミューノヴァクシーン テクノロジーズ インコーポレイテッドImmunovaccine Technologies Inc. ポリｉ：ｃポリヌクレオチドアジュバント及び脂質系アジュバントを含むアジュバント系及び水を含まないワクチン組成物
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JP7125197B2 (ja) 2016-09-27 2022-08-24 イミューノヴァクシーン テクノロジーズ インコーポレイテッド ヒト対象において抗体免疫応答を誘導するために低投与体積ｂ細胞エピトープ組成物を使用する方法
AU2019239785A1 (en) * 2018-03-20 2020-10-08 Immunovaccine Technologies Inc. Methods and compositions for targeted delivery of active agents and immunomodulatory agents to lymph nodes
RS65200B1 (sr) * 2019-03-04 2024-03-29 Aurealis Therapeutics AG Prokariotski ekspresioni sistem inducibilan hloridom
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