CN106309752A - Traditional Chinese medicine composition for preventing and treating colibacillosis of livestock and poultry and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for preventing and treating colibacillosis of livestock and poultry and preparation method of traditional Chinese medicine composition Download PDFInfo
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- CN106309752A CN106309752A CN201610759388.2A CN201610759388A CN106309752A CN 106309752 A CN106309752 A CN 106309752A CN 201610759388 A CN201610759388 A CN 201610759388A CN 106309752 A CN106309752 A CN 106309752A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention provides traditional Chinese medicine composition for preventing and treating colibacillosis of livestock and poultry and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises raw materials by weight as follows: cherokee rose fruit, cherokee rose root, bigleaf beautyberry leaf, coptis, common macrocarpium fruit, atractylodes rhizome, burnt alum, indigowoad leaf and dandelion root. According to the traditional Chinese medicine composition for preventing and treating colibacillosis of livestock and poultry and the preparation method of the traditional Chinese medicine composition, native traditional Chinese medicine dialectically indicates that the disease is caused by humid heat locking the middle energizer and invasion of pathogenic qi. Tests discover that the cherokee rose fruit, the cherokee rose root, the bigleaf beautyberry leaf, the coptis, the common macrocarpium fruit, the atractylodes rhizome, the indigowoad leaf, the dandelion root and the burnt alum in the formula all have an antibacterial effect and also have effects of stopping bleeding, resisting ulcers, diminishing swelling, relieving dysentery and resisting endotoxin of escherichia coli. The dosage form of the traditional Chinese medicine composition is an oral liquid, sick livestock and poultry are fed more conveniently, a feeder controls and adjusts the dosage easily during use, and a remarkable curative effect on preventing and treating the colibacillosis of the livestock and poultry is realized.
Description
Technical field
The present invention relates to veterinary Chinese medicine and preparation method thereof, a kind of Chinese medicine for preventing and treating poultry colibacillosis
Compositions and preparation method thereof.
Background technology
Escherichia coli are the modal a kind of pathogenic bacterium of poultry, and diseased individuals once occurs in the poultry of breeding scale, if
If uncontrolled, can infect the most on a large scale, carry out great economic loss to cultivation industrial belt.This disease is that a kind of conditionality infects
, there is diarrhoea, heating, oliguria, is likely to occur septicemia subsequently, pathogenic factor includes inside and outside two aspect factors in disease after morbidity.Outward
Severe environmental pollution, causes escherichia coli amount reproduction, poultry contact to cause infection；Animal and bird intestines environment is unbalance, causes harmful
Escherichia coli are increased, and intestinal wall is impaired, and escherichia coli enter blood, cause escherichia coli to fall ill in other tissue propagation.In recent years
In order to prevent and treat this disease, the antibacterial of a large amount of use antibiotic and chemosynthesis antibacterial, antibiotic and chemosynthesis is in poultry
The internal metabolism cycle is long, residual easily occurs, carrys out the biggest hidden danger to food seat belt.Fresh rare to using Chinese medicine preparation to control
The case treated.
Therefore, it is badly in need of one and eliminates the Chinese medicine composition of " damp and hot middle resistance ", fundamentally treat the disease of poultry, heat clearing away solution
Poison, dampness-eliminating and dysentery-stopping.
Summary of the invention
In order to solve poultry, due to living environment pollution or intestinal environment is unbalance and the colibacillosis that causes, the present invention's
Purpose is to propose a kind of Chinese medicine composition for preventing and treating poultry colibacillosis and preparation method thereof, and this prescription is raiseeed by regulation
Environment in fowl, suppresses the growth and breeding of pathogen simultaneously, thus reaches to prevent and treat the purpose of this disease.
A kind of Chinese medicine composition for preventing and treating poultry colibacillosis, according to weight ratio, the Chinese medicine composition described in composition
The raw material of thing is 10-15 part Fructus Rosae Laevigatae, 10-15 part Radix Rosae Laevigatae, the big Folium Alangii of 10-15 part, 10-15 part Rhizoma Coptidis, 10-15 part mountain Zhu
Cornel, 10-15 part Rhizoma Atractylodis and 2-5 part dried Alumen.
According to weight portion, the raw material forming described Chinese medicine composition also comprises 10-15 part Folium Isatidis and 10-15 part Herba Taraxaci
Root.
A kind of preparation method of the Chinese medicine composition for preventing and treating poultry colibacillosis, the dosage form of described Chinese medicine composition
For oral liquid, its preparation method includes:
Step one, according to parts by weight, take Fructus Rosae Laevigatae, Radix Rosae Laevigatae, big Folium Alangii, Rhizoma Coptidis, Fructus Corni, Rhizoma Atractylodis, dried Alumen, Folium Isatidis respectively
Leaf and Radix Taraxaci, standby；
Step 2, take mix homogeneously after Fructus Corni and Rhizoma Coptidis are pulverized, steam 40min, dry standby；
Step 3, taking Fructus Rosae Laevigatae and smash, Rhizoma Atractylodis, Radix Rosae Laevigatae and Radix Taraxaci are thinly sliced, and dried Alumen is pulverized, standby；
Step 4, in the mixture of Fructus Rosae Laevigatae, Radix Rosae Laevigatae, Fructus Corni, Rhizoma Coptidis, Rhizoma Atractylodis and Radix Taraxaci add mixture total weight
The water of 8 times amount, soaks 2h, heats and is allowed to the 1.5h that seethes with excitement, then put into Folium Isatidis and big Folium Alangii wherein, continues ebuillition of heated
30min, filters to obtain medicinal liquid a and medicinal residues a, standby；
Step 5, in medicinal residues a add medicinal residues a gross weight 6 times amount water, ebuillition of heated 1h, filter to obtain medicinal liquid a, standby；
Step 6, medicinal liquid a and medicinal liquid b are mixed, add alumen powder, be thoroughly mixed uniformly, obtain mixed liquor, vacuum and low temperature
Concentrated filtrate, to the 60% of its original volume, is centrifuged by concentration mixed liquor, collects supernatant；
Step 7, supernatant is carried out fill, steam sterilization, obtain the Chinese medicine oral liquid for preventing and treating poultry colibacillosis.
Wherein, in step 4, in boiling process, if the accounting of liquid less than adding fashionable amount, then supplement hot water with
Prevent moisture from seething with excitement and dry pot.
Described filtrate is concentrated in vacuo to the 60% of its original volume in the environment of 5 DEG C.
Described concentrated filtrate rotating speed with 14600r/min on high speed centrifuge is centrifuged 20min.
Supernatant after described fill is sterilizing 30min under the steam of 100 DEG C.
Beneficial effects of the present invention:
A kind of Chinese medicine composition for preventing and treating poultry colibacillosis of the present invention and preparation method thereof, motherland's Syndrome Differentiation of Chinese Medicine
Identification is, this disease belongs to damp and hot middle resistance, and oxious gas invasion is caused.It is primarily due to caused by " damp and hot middle resistance " the most damp and the hottest delay intestinal.Side
Middle Rhizoma Coptidis heat clearing and damp drying is monarch drug, the Rhizoma Coptidis concocted with the Fructus Evodiae, and antibacterial effect is more preferable；Rhizoma Atractylodis dampness dirt eliminating, helps the gesture of Rhizoma Coptidis；
Fructus Rosae Laevigatae, that Radix Rosae Laevigatae is sour and astringent is solid de-, and big blade, dried Alumen astringing to arrest bleeding, Folium Isatidis, Herba Taraxaci clearing away heat and promoting diuresis, beneficially toxin are discharged.
Test finds Fructus Rosae Laevigatae, Radix Rosae Laevigatae, big blade, Rhizoma Coptidis, Fructus Corni, Rhizoma Atractylodis, Folium Isatidis, Herba Taraxaci, dried Alumen in prescription, all has anti-
Bacterium effect.The made medicinal liquid of the party has inside and outside antibacterial effect.And there is hemostasis, antiulcer, detumescence, dysentery relieving, anti-large intestine simultaneously
The endotoxic effect of bacillus.And the dosage form of Chinese medicine is oral liquid, by the concentration to Chinese medicine, it is possible to more convenient throwing something and feeding is ill
Poultry, poultry raiser is easily controlled in use and adjusts consumption, and preventing and treating poultry colibacillosis is had significant curative effect.
Detailed description of the invention
In conjunction with specific examples below, the present invention is described in further detail, and protection scope of the present invention is not limited to
In following example.Implement the process of the present invention, condition, reagent, experimental technique etc., outside the lower content mentioned specially,
Being universal knowledege and the common knowledge of this area, the present invention is not particularly limited content.
Embodiment 1
The preparation method of a kind of Chinese medicine composition for preventing and treating poultry colibacillosis, the dosage form of described Chinese medicine composition is mouth
Taking liquid, its preparation method includes:
Step one, according to parts by weight, take respectively 10 portions of Fructus Rosae Laevigatae, 10 parts of Radix Rosae Laevigataes, 10 parts of big Folium Alangives, 10 portions of Rhizoma Coptidis, 10 parts
Fructus Corni, 10 parts of Rhizoma Atractylodis, 2 parts of dried Alumens, 10 portions of Folium Isatidiss and 10 parts of Radix Taraxacis, standby；
Step 2, take mix homogeneously after Fructus Corni and Rhizoma Coptidis are pulverized, steam 40min, dry standby；
Step 3, taking Fructus Rosae Laevigatae and smash, Rhizoma Atractylodis, Radix Rosae Laevigatae and Radix Taraxaci are thinly sliced, and dried Alumen is pulverized, standby；
Step 4, in the mixture of Fructus Rosae Laevigatae, Radix Rosae Laevigatae, Fructus Corni, Rhizoma Coptidis, Rhizoma Atractylodis and Radix Taraxaci add mixture total weight
The water of 8 times amount, soaks 2h, heats and is allowed to the 1.5h that seethes with excitement, then put into Folium Isatidis and big Folium Alangii wherein, continues ebuillition of heated
30min, filters to obtain medicinal liquid a and medicinal residues a, standby；
Step 5, in medicinal residues a add medicinal residues a gross weight 6 times amount water, ebuillition of heated 1h, filter to obtain medicinal liquid a, standby；
Step 6, medicinal liquid a and medicinal liquid b are mixed, add alumen powder, be thoroughly mixed uniformly, obtain mixed liquor, at 5 DEG C
Mixed liquor be concentrated in vacuo under environment to the 60% of its original volume, to concentrated filtrate on high speed centrifuge with 14600r/
The rotating speed of min is centrifuged 20min, collects supernatant；
Step 7, supernatant is carried out fill, sterilizing 30min under the steam of 100 DEG C, obtain for preventing and treating poultry escherichia coli
Sick Chinese medicine oral liquid.
Embodiment 2
The preparation method of a kind of Chinese medicine composition for preventing and treating poultry colibacillosis, the dosage form of described Chinese medicine composition is mouth
Taking liquid, its preparation method includes:
Step one, according to parts by weight, take respectively 11 portions of Fructus Rosae Laevigatae, 11 parts of Radix Rosae Laevigataes, 11 parts of big Folium Alangives, 11 portions of Rhizoma Coptidis, 11 parts
Fructus Corni, 11 parts of Rhizoma Atractylodis, 3 parts of dried Alumens, 11 portions of Folium Isatidiss and 11 parts of Radix Taraxacis, standby；
Step 2, take mix homogeneously after Fructus Corni and Rhizoma Coptidis are pulverized, steam 40min, dry standby；
Step 3, taking Fructus Rosae Laevigatae and smash, Rhizoma Atractylodis, Radix Rosae Laevigatae and Radix Taraxaci are thinly sliced, and dried Alumen is pulverized, standby；
Step 4, in the mixture of Fructus Rosae Laevigatae, Radix Rosae Laevigatae, Fructus Corni, Rhizoma Coptidis, Rhizoma Atractylodis and Radix Taraxaci add mixture total weight
The water of 8 times amount, soaks 2h, heats and is allowed to the 1.5h that seethes with excitement, then put into Folium Isatidis and big Folium Alangii wherein, continues ebuillition of heated
30min, filters to obtain medicinal liquid a and medicinal residues a, standby；
Step 5, in medicinal residues a add medicinal residues a gross weight 6 times amount water, ebuillition of heated 1h, filter to obtain medicinal liquid a, standby；
Step 6, medicinal liquid a and medicinal liquid b are mixed, add alumen powder, be thoroughly mixed uniformly, obtain mixed liquor, at 5 DEG C
Mixed liquor be concentrated in vacuo under environment to the 60% of its original volume, to concentrated filtrate on high speed centrifuge with 14600r/
The rotating speed of min is centrifuged 20min, collects supernatant；
Step 7, supernatant is carried out fill, sterilizing 30min under the steam of 100 DEG C, obtain for preventing and treating poultry escherichia coli
Sick Chinese medicine oral liquid.
Embodiment 3
The preparation method of a kind of Chinese medicine composition for preventing and treating poultry colibacillosis, the dosage form of described Chinese medicine composition is mouth
Taking liquid, its preparation method includes:
Step one, according to parts by weight, take respectively 12 portions of Fructus Rosae Laevigatae, 12 parts of Radix Rosae Laevigataes, 12 parts of big Folium Alangives, 12 portions of Rhizoma Coptidis, 12 parts
Fructus Corni, 12 parts of Rhizoma Atractylodis, 4 parts of dried Alumens, 12 portions of Folium Isatidiss and 12 parts of Radix Taraxacis, standby；
Step 2, take mix homogeneously after Fructus Corni and Rhizoma Coptidis are pulverized, steam 40min, dry standby；
Step 3, taking Fructus Rosae Laevigatae and smash, Rhizoma Atractylodis, Radix Rosae Laevigatae and Radix Taraxaci are thinly sliced, and dried Alumen is pulverized, standby；
Step 4, in the mixture of Fructus Rosae Laevigatae, Radix Rosae Laevigatae, Fructus Corni, Rhizoma Coptidis, Rhizoma Atractylodis and Radix Taraxaci add mixture total weight
The water of 8 times amount, soaks 2h, heats and is allowed to the 1.5h that seethes with excitement, then put into Folium Isatidis and big Folium Alangii wherein, continues ebuillition of heated
30min, filters to obtain medicinal liquid a and medicinal residues a, standby；
Step 5, in medicinal residues a add medicinal residues a gross weight 6 times amount water, ebuillition of heated 1h, filter to obtain medicinal liquid a, standby；
Step 6, medicinal liquid a and medicinal liquid b are mixed, add alumen powder, be thoroughly mixed uniformly, obtain mixed liquor, at 5 DEG C
Mixed liquor be concentrated in vacuo under environment to the 60% of its original volume, to concentrated filtrate on high speed centrifuge with 14600r/
The rotating speed of min is centrifuged 20min, collects supernatant；
Step 7, supernatant is carried out fill, sterilizing 30min under the steam of 100 DEG C, obtain for preventing and treating poultry escherichia coli
Sick Chinese medicine oral liquid.
Embodiment 4
The preparation method of a kind of Chinese medicine composition for preventing and treating poultry colibacillosis, the dosage form of described Chinese medicine composition is mouth
Taking liquid, its preparation method includes:
Step one, according to parts by weight, take respectively 14 portions of Fructus Rosae Laevigatae, 14 parts of Radix Rosae Laevigataes, 14 parts of big Folium Alangives, 14 portions of Rhizoma Coptidis, 14 parts
Fructus Corni, 14 parts of Rhizoma Atractylodis, 5 parts of dried Alumens, 14 portions of Folium Isatidiss and 14 parts of Radix Taraxacis, standby；
Step 2, take mix homogeneously after Fructus Corni and Rhizoma Coptidis are pulverized, steam 40min, dry standby；
Step 3, taking Fructus Rosae Laevigatae and smash, Rhizoma Atractylodis, Radix Rosae Laevigatae and Radix Taraxaci are thinly sliced, and dried Alumen is pulverized, standby；
Step 4, in the mixture of Fructus Rosae Laevigatae, Radix Rosae Laevigatae, Fructus Corni, Rhizoma Coptidis, Rhizoma Atractylodis and Radix Taraxaci add mixture total weight
The water of 8 times amount, soaks 2h, heats and is allowed to the 1.5h that seethes with excitement, then put into Folium Isatidis and big Folium Alangii wherein, continues ebuillition of heated
30min, filters to obtain medicinal liquid a and medicinal residues a, standby；
Step 5, in medicinal residues a add medicinal residues a gross weight 6 times amount water, ebuillition of heated 1h, filter to obtain medicinal liquid a, standby；
Step 6, medicinal liquid a and medicinal liquid b are mixed, add alumen powder, be thoroughly mixed uniformly, obtain mixed liquor, at 5 DEG C
Mixed liquor be concentrated in vacuo under environment to the 60% of its original volume, to concentrated filtrate on high speed centrifuge with 14600r/
The rotating speed of min is centrifuged 20min, collects supernatant；
Step 7, supernatant is carried out fill, sterilizing 30min under the steam of 100 DEG C, obtain for preventing and treating poultry escherichia coli
Sick Chinese medicine oral liquid.
Embodiment 5
The preparation method of a kind of Chinese medicine composition for preventing and treating poultry colibacillosis, the dosage form of described Chinese medicine composition is mouth
Taking liquid, its preparation method includes:
Step one, according to parts by weight, take respectively 15 portions of Fructus Rosae Laevigatae, 15 parts of Radix Rosae Laevigataes, 15 parts of big Folium Alangives, 15 portions of Rhizoma Coptidis, 15 parts
Fructus Corni, 15 parts of Rhizoma Atractylodis, 5 parts of dried Alumens, 15 portions of Folium Isatidiss and 15 parts of Radix Taraxacis, standby；
Step 2, take mix homogeneously after Fructus Corni and Rhizoma Coptidis are pulverized, steam 40min, dry standby；
Step 3, taking Fructus Rosae Laevigatae and smash, Rhizoma Atractylodis, Radix Rosae Laevigatae and Radix Taraxaci are thinly sliced, and dried Alumen is pulverized, standby；
Step 4, in the mixture of Fructus Rosae Laevigatae, Radix Rosae Laevigatae, Fructus Corni, Rhizoma Coptidis, Rhizoma Atractylodis and Radix Taraxaci add mixture total weight
The water of 8 times amount, soaks 2h, heats and is allowed to the 1.5h that seethes with excitement, then put into Folium Isatidis and big Folium Alangii wherein, continues ebuillition of heated
30min, filters to obtain medicinal liquid a and medicinal residues a, standby；
Step 5, in medicinal residues a add medicinal residues a gross weight 6 times amount water, ebuillition of heated 1h, filter to obtain medicinal liquid a, standby；
Step 6, medicinal liquid a and medicinal liquid b are mixed, add alumen powder, be thoroughly mixed uniformly, obtain mixed liquor, at 5 DEG C
Mixed liquor be concentrated in vacuo under environment to the 60% of its original volume, to concentrated filtrate on high speed centrifuge with 14600r/
The rotating speed of min is centrifuged 20min, collects supernatant；
Step 7, supernatant is carried out fill, sterilizing 30min under the steam of 100 DEG C, obtain for preventing and treating poultry escherichia coli
Sick Chinese medicine oral liquid.
Usage and consumption:
It is oral: domestic animal is thrown something and fed according to per kilogram of body weight 0.25-0.5 mL according to per kilogram of body weight 0.2-0.3 mL, poultry,
Every day 2-3 time.
Drinking-water: every 1L water adds medicinal liquid 2-10 mL, freely drinks for poultry.
Treatment case:
Case one,
Kaifeng chicken house, the laying chickling of 30 ages in days 3000, sudden death, death every day 15-20 only, cuts open inspection symptom: bag
The heart, bag liver, peritoneal adhesion, intestinal mucosa comes off, and sick chicken draws green or water sample loose stool, is diagnosed as colibacillosis.
Therapeutic scheme: 1, chosen by the chickling being in a bad way, every gavages oral liquid 0.3mL of the present invention, every day 2
Secondary.Cure after being used in conjunction 4 days.2, in chicken house drinking-water, every 3 liters of water add oral liquid 300mL of the present invention, freely drinks for chickling
With, even to drink 5 days, chicken group's feces is normal, and spirit and diet are all normal, and dead stopping is considered as curing.
Case two,
, there is Hakuri, be diagnosed as colibacillosis in pig farm, Jiaxian County, Henan, totally 96 15 age in days piglets.
Therapeutic scheme: use oral liquid of the present invention to gavage according to the consumption of piglet per kilogram of body weight 0.25ml,
Three times a day, 3 it are used in conjunction.Wherein, curing 86, symptom alleviates 6.Cure rate 90%, effective percentage 96%.
Case three,
Earthquake of Anyang station in Henan chicken house, the white meat-type chickens of 12000 22 ages in days, occur that intestinal wall is thinning, intestinal lamellar is hemorrhage, and mesentery has
The symptoms such as yellow fibers sexual secretion, and part broiler has perihepatitis, is diagnosed as colibacillosis, death every day 40-50 is only.
Therapeutic scheme: in chicken house drinking-water, add oral liquid 4800mL of the present invention in every 10 liters of water, freely drink for broiler
With, it being used in conjunction 3 days, chicken group's feces is normal, and spirit and diet are all normal, and mortality rate is reduced to every day about 5, is considered as curing.
Claims (6)
1. one kind for preventing and treating the Chinese medicine composition of poultry colibacillosis, it is characterised in that: according to weight ratio, described in composition
The raw material of Chinese medicine composition is 10-15 part Fructus Rosae Laevigatae, 10-15 part Radix Rosae Laevigatae, the big Folium Alangii of 10-15 part, 10-15 part Rhizoma Coptidis, 10-15
Part Fructus Corni, 10-15 part Rhizoma Atractylodis and 2-5 part dried Alumen.
A kind of Chinese medicine composition for preventing and treating poultry colibacillosis, it is characterised in that: according to
Weight portion, the raw material forming described Chinese medicine composition also comprises 10-15 part Folium Isatidis and 10-15 part Radix Taraxaci.
A kind of preparation method of the Chinese medicine composition for preventing and treating poultry colibacillosis, its
It is characterised by: the dosage form of described Chinese medicine composition is oral liquid, and its preparation method includes:
Step one, according to parts by weight, take Fructus Rosae Laevigatae, Radix Rosae Laevigatae, big Folium Alangii, Rhizoma Coptidis, Fructus Corni, Rhizoma Atractylodis, dried Alumen, Folium Isatidis respectively
Leaf and Radix Taraxaci, standby；
Step 2, take mix homogeneously after Fructus Corni and Rhizoma Coptidis are pulverized, steam 40min, dry standby；
Step 3, taking Fructus Rosae Laevigatae and smash, Rhizoma Atractylodis, Radix Rosae Laevigatae and Radix Taraxaci are thinly sliced, and dried Alumen is pulverized, standby；
Step 4, in the mixture of Fructus Rosae Laevigatae, Radix Rosae Laevigatae, Fructus Corni, Rhizoma Coptidis, Rhizoma Atractylodis and Radix Taraxaci add mixture total weight
The water of 8 times amount, soaks 2h, heats and is allowed to the 1.5h that seethes with excitement, then put into Folium Isatidis and big Folium Alangii wherein, continues ebuillition of heated
30min, filters to obtain medicinal liquid a and medicinal residues a, standby；
Step 5, in medicinal residues a add medicinal residues a gross weight 6 times amount water, ebuillition of heated 1h, filter to obtain medicinal liquid a, standby；
Step 6, medicinal liquid a and medicinal liquid b are mixed, add alumen powder, be thoroughly mixed uniformly, obtain mixed liquor, vacuum and low temperature
Concentrated filtrate, to the 60% of its original volume, is centrifuged by concentration mixed liquor, collects supernatant；
Step 7, supernatant is carried out fill, steam sterilization, obtain the Chinese medicine oral liquid for preventing and treating poultry colibacillosis.
The preparation method of a kind of Chinese medicine composition for preventing and treating poultry colibacillosis, it is special
Levy and be: described filtrate is concentrated in vacuo to the 60% of its original volume in the environment of 5 DEG C.
The preparation method of a kind of Chinese medicine composition for preventing and treating poultry colibacillosis, it is special
Levy and be: described concentrated filtrate rotating speed with 14600r/min on high speed centrifuge is centrifuged 20min.
The preparation method of a kind of Chinese medicine composition for preventing and treating poultry colibacillosis, it is special
Levy and be: the supernatant after described fill is sterilizing 30min under the steam of 100 DEG C.
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