CN106236920A - 一种治疗急性荨麻疹的丸剂药物及其制备方法 - Google Patents

一种治疗急性荨麻疹的丸剂药物及其制备方法 Download PDF

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CN106236920A
CN106236920A CN201610813298.7A CN201610813298A CN106236920A CN 106236920 A CN106236920 A CN 106236920A CN 201610813298 A CN201610813298 A CN 201610813298A CN 106236920 A CN106236920 A CN 106236920A
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夏瑜
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Sichuan Jintang Haina Biomedical Technology Institute
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Abstract

本发明属于中药制剂领域，目的是根据中医对急性荨麻疹的认识机理而提供的一种治疗急性荨麻疹的丸剂药物，所述药物的各个组分及其质量份比如下：白藓皮、牡丹皮、白术、僵蚕、荆芥、蝉蜕、防风、牛蒡子、厚朴、生地、当归、赤芍、桃仁、红花、熟地、独活、防己、川穹、羌活、白蒺藜、茯苓、元参、桂枝、何首乌、焦栀子、生甘草；本发明提供的药物是一个很好的中药组方。

Description

一种治疗急性荨麻疹的丸剂药物及其制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种治疗急性荨麻疹的丸剂药物，特别是供急性荨麻疹患者使用的丸剂药物及其制备方法的领域。
背景技术
急性荨麻疹（AU）是一种临床常见病，以瘙痒、风团或伴有血管性水肿为特征的变应性皮肤病，是由于皮肤、黏膜小血管扩张及渗透性增加而出现的一种局限性水肿反应。
临床表现：急性发作，全身有瘙痒及大小不一的风团发生。风团可相互融合成大片皮损，或成地图样损害。口唇可肿胀，或咽峡部肿胀而造成喉头水肿，致使呼吸困难，甚至窒息。皮损往往在数小时内消退，但此起彼伏，不断发生新的损害。
全身可伴发热，呼吸道症状可有哮喘与呼吸困难。肠道可有腹痛或腹胀，可伴腹泻。严重患者可有低血压、头晕、胸闷等症状，极少数发生休克。大多数患者仅有风团、瘙痒，而无其他症状。
那么，就如何找到一种可有效治疗上述急性荨麻疹的药物，是我们目前急需要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗急性荨麻疹上，人们逐渐意识到了中医治疗急性荨麻疹的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗急性荨麻疹的现状，本发明的目的是在于提供一种治疗急性荨麻疹的丸剂药物，以解决急性荨麻疹患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及其质量份比，可有效治疗上述急性荨麻疹。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种治疗急性荨麻疹的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示。
白藓皮100～260g、牡丹皮80～160g、白术30～160g、僵蚕30～120g、荆芥80～160g、蝉蜕30～60g、防风80～160g、牛蒡子50～120g、厚朴50～160g、生地100～300g、当归80～160g、赤芍60～120g、桃仁80～160g、红花50～120g、熟地100～300g、独活30～100g、防己50～100g、川穹30～100g、羌活100～260g、白蒺藜60～100g、茯苓150～260g、元参80～160g、桂枝20～60g、何首乌150～260g、焦栀子6～9g、生甘草15～100g。
一种治疗急性荨麻疹的丸剂药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
白藓皮120～230g、牡丹皮100～140g、白术40～140g、僵蚕30～100g、荆芥100～140g、蝉蜕40～50g、防风90～140g、牛蒡子60～100g、厚朴60～140g、生地115～260g、当归100～140g、赤芍80～100g、桃仁100～140g、红花60～100g、熟地120～260g、独活40～85g、防己60～85g、川穹40～85g、羌活115～230g、白蒺藜70～85g、茯苓180～230g、元参100～140g、桂枝30～50g、何首乌180～230g、焦栀子6～8g、生甘草16～85g。
一种治疗急性荨麻疹的丸剂药物及其制备方法，其特征在于，所述“最佳方案”的药物的各个组分及其质量份比如下所示：
白藓皮200g、牡丹皮120g、白术120g、僵蚕85g、荆芥120g、蝉蜕45g、防风120g、牛蒡子85g、厚朴120g、生地230g、当归120g、赤芍85g、桃仁120g、红花85g、熟地230g、独活75g、防己75g、川穹75g、羌活200g、白蒺藜75g、茯苓200g、元参120g、桂枝45g、何首乌200g、焦栀子7g、生甘草75g。
一种治疗急性荨麻疹的丸剂药物及其制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、将上述原料中药拣去杂质、粉尘，及干燥后，按照质量份比共研为极细末待用；
B、按照传统制备中药水丸剂的方法，将研磨好的极细末药物过筛后，放入药器中混合拌均，然后制备成水丸剂（其水丸的粒度为：4.8mm-4.9mm），进而晒干，分装密封即可。
一种治疗急性荨麻疹的丸剂药物及其制备方法，其特征在于，所述服用方法为：将制备好的水丸剂药物以每日二次服用，早晚各服一次，给药量10g/次，饭前半小时服，10天为一个疗程，服药4～5个疗程后，诸症消失，病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
白藓皮，性味：苦咸、寒，具有祛风、燥湿、清热、解毒之功效，用于治疗风热疮毒、疥癣、皮肤痒疹、风湿痹痛、黄疸等症；
牡丹皮，性味：辛苦、凉、微寒，具有清热、活血散瘀之功效，用于治疗温热病热入血分、发斑、吐衄、热泪盈眶病菌后期热伏阴分发热、阴虚骨蒸潮热、血滞经闭、痛经、痈肿疮毒、跌扑伤痛、风湿热痹等症；
白术，性味：味苦、甘、性温，具有健脾益气、燥湿利水、止汗、安胎之功效，用于治疗脾气虚弱、神疲乏力、食少少腹胀、大便溏薄、水饮内停、小便不利、水肿、痰饮眩晕、温痹酸痛、气虚自汗、胎动不安；
僵蚕，性味：味辛、咸、性平，具有祛风止痉、化痰散结、解毒利咽之功效，用于治疗惊痫抽搐、中风口、眼斜、偏正头痛、咽喉肿痛、瘰疬、痄腮、风疹、疮毒等症；
荆芥，性味：辛、温，具有发表、祛风、理血、炒炭止血之功效，用于治疗感冒发热、头痛、咽喉肿痛、中风口噤、吐血、衄血、便血、崩漏、产后血晕、痈肿、疮疥、瘰疬等症；
蝉蜕，性味：味甘、咸、性凉，具有宣散风热、透疹利咽、退翳明目、祛风止痉之功效，用于治疗风热感冒、咽喉肿痛、咳嗽音哑、单板机疹不透、风疹瘙痒、目赤翳障、惊痫抽搐、破伤风等症；
防风，性味：辛甘、温，具有发表、祛风、胜湿、止痛之功效，用于治疗外感风寒、头痛、目眩、项强、风寒湿痹、骨节酸痛、四肢挛急、破伤风等症；
牛蒡子，性味：味辛、苦、性寒，具有疏散风热、宣肺透疹、利咽散结、解毒消肿之功效，用于治疗风热咳嗽、咽喉肿痛、斑疹不透、风疹瘙痒、疮疡肿毒；
厚朴，性味：苦辛、温，具有温中、下气、燥湿、消痰之功效，用于治疗胸腹痞满胀痛、反胃、呕吐、宿食不消、痰饮喘咳、寒湿泻痢等症；
生地，性味：味甘、苦、性寒，具有清热凉血、生津润燥之功效，用于治疗急性热病、高热神昏、斑疹、津伤烦渴、血热妄行之吐血、衄血、崩漏、便血、口舌生疮、咽喉肿痛、劳热咳嗽、跌打伤痛、痈肿等症；
当归，性味：性温、味甘辛, 具有补血和血、调经止痛、润燥滑肠之功效，用于治疗血虚、面色萎黄、眩晕心悸、血虚、或兼有瘀滞的月经不调、经闭、痛经、虚寒性腹痛、冠心病心绞痛、风湿痹痛、跌打损伤等症；
赤芍，性味：微寒，具有清热凉血、活血祛瘀之功效，用于治疗温毒发斑、吐血衄血、肠风下血、目赤肿痛、痈肿疮疡、闭经、痛经、崩带淋浊、瘀滞胁痛、疝瘕积聚、跌扑损伤等症；
桃仁，性味：苦甘、平，具有破血行瘀、润燥滑肠之功效，用于治疗经闭、症瘕、热病蓄血、风痹、疟疾、跌打损伤、瘀血肿痛、血燥便秘等症；
红花，性味：味辛、性温，具有活血能经、祛瘀止痛之功效，用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛症瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症；
熟地，性味：味甘、性温，具有补血滋润、益精填髓之功效，用于治疗血虎萎黄、眩晕心悸、月经不调、崩不止、肝肾阴亏、潮热盗汗、遗精阳痿、不育不孕、腰膝酸软、耳鸣耳聋、头目昏花、须发早白、消渴、便秘、肾虚喘促等症；
独活，性味：味苦、辛、性微湿，具有祛风胜湿、散寒止痛之功效，用于治疗风寒湿痹、腰膝疼痛、头痛齿痛等症；
防己，性味：苦、寒，具有利水消肿、祛风止痛之功效，用于治疗水肿脚气、小便不利、湿疹疮毒、风湿痹痛、高血压；
川穹，性味：辛、温，具有活血行气、祛风止痛之功效，用于治疗气滞血瘀之胸胁、腹部诸痛、肝郁气滞之胁痛、心脉瘀阻之胸痹心痛、肝血瘀阻、积聚痞块、胸胁刺痛、跌仆损伤、瘀肿疼痛、血瘀经闭、产后恶漏不下、月经不调、寒凝血滞、难产、胞衣不下；
羌活，性味：辛苦、温，具有散表寒、祛风湿、利关节之功效，用于治疗感冒风寒、头痛无汗、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒等症；
白蒺藜，性味：苦、辛、平，具有平肝解郁、祛风明目之功效，用于治疗肝阳眩晕头痛、肝郁胁痛、风热头痛、目赤肿痛、皮肤瘙痒等症；
茯苓，性味：甘、淡、平，具有渗湿利水、健脾和胃、宁心安神之功效，用于治疗小便不利、水肿胀满、痰饮咳逆、呕吐、脾虚食少、泄泻、心悸不安、失眠健忘、遗精白浊等症；
元参，性味：味甘、苦、咸、性微寒，具有清热凉血、滋阴降火、解毒散结之功效，用于治疗温热病热和营血、身热、烦渴、舌绛、发斑、骨蒸劳嗽、虚烦不寤、津伤便秘、目涩昏花、咽喉喉肿痛、瘰疬痰核、痈疽疮毒；
桂枝，性味：性味：辛、甘、性温，具有散寒解表、温通经脉、促阳化气之功效，用于治疗风寒表证、寒湿痹痛、四肢厥冷、经闭痛经、癥瘕结块、胸痹、心悸、痰饮、小便不利；
何首乌，性味：苦甘涩、微温，具有补肝、益肾、养血、祛风之功效，用于治疗肝肾阴亏、发须早白、血虚头晕、腰膝软弱、筋骨酸痛、遗精、崩带、久疟、久痢、慢性肝炎、痈肿、瘰疬、肠风、痔疾等症；
焦栀子，性味：苦、寒，具有凉血止血之功效，用于治疗血热吐衄、尿血崩漏；
生甘草，性味：甘、平，具有补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药之功效，用于治疗脾胃虚弱、倦怠乏力、心悸气短、咳嗽痰多、脘腹、四肢挛急疼痛、痈肿疮毒、缓解药物毒性、烈性等。
本发明药物是基于中医治疗急性荨麻疹的辨病与辨证相结合的原则，从药理作用及作用机制认为：就急性荨麻疹，本发明所提供的药物中的各原料中药药效共奏，对上述急性荨麻疹有很好的治疗效果。
具体实施方式
本发明就是针对上述急性荨麻疹的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个标本兼治的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述。
实施例1：
一种治疗急性荨麻疹的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
白藓皮200g、牡丹皮120g、白术120g、僵蚕85g、荆芥120g、蝉蜕45g、防风120g、牛蒡子85g、厚朴120g、生地230g、当归120g、赤芍85g、桃仁120g、红花85g、熟地230g、独活75g、防己75g、川穹75g、羌活200g、白蒺藜75g、茯苓200g、元参120g、桂枝45g、何首乌200g、焦栀子7g、生甘草75g。
实施例2：
一种治疗急性荨麻疹的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
白藓皮230g、牡丹皮140g、白术140g、僵蚕100g、荆芥140g、蝉蜕50g、防风140g、牛蒡子100g、厚朴140g、生地260g、当归140g、赤芍100g、桃仁140g、红花100g、熟地260g、独活85g、防己85g、川穹85g、羌活230g、白蒺藜85g、茯苓230g、元参140g、桂枝50g、何首乌230g、焦栀子8g、生甘草85g。
实施例3：
一种治疗急性荨麻疹的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
白藓皮260g、牡丹皮160g、白术160g、僵蚕120g、荆芥160g、蝉蜕60g、防风160g、牛蒡子120g、厚朴160g、生地300g、当归160g、赤芍120g、桃仁160g、红花120g、熟地300g、独活100g、防己100g、川穹100g、羌活260g、白蒺藜100g、茯苓260g、元参160g、桂枝60g、何首乌260g、焦栀子9g、生甘草100g。
典型病例
经临床诊断治疗急性荨麻疹患者共580例，年龄为42岁以上的300例，只有280例为42岁以下。580例患者中痊愈的562例，显效的18例，总有效率达100%。

Claims (3)

1.一种治疗急性荨麻疹的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
白藓皮100～260g、牡丹皮80～160g、白术30～160g、僵蚕30～120g、荆芥80～160g、蝉蜕30～60g、防风80～160g、牛蒡子50～120g、厚朴50～160g、生地100～300g、当归80～160g、赤芍60～120g、桃仁80～160g、红花50～120g、熟地100～300g、独活30～100g、防己50～100g、川穹30～100g、羌活100～260g、白蒺藜60～100g、茯苓150～260g、元参80～160g、桂枝20～60g、何首乌150～260g、焦栀子6～9g、生甘草15～100g。
2.根据权利要求1所述的治疗急性荨麻疹的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
白藓皮120～230g、牡丹皮100～140g、白术40～140g、僵蚕30～100g、荆芥100～140g、蝉蜕40～50g、防风90～140g、牛蒡子60～100g、厚朴60～140g、生地115～260g、当归100～140g、赤芍80～100g、桃仁100～140g、红花60～100g、熟地120～260g、独活40～85g、防己60～85g、川穹40～85g、羌活115～230g、白蒺藜70～85g、茯苓180～230g、元参100～140g、桂枝30～50g、何首乌180～230g、焦栀子6～8g、生甘草16～85g。
3.根据权利要求1至2所述的治疗急性荨麻疹的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
白藓皮200g、牡丹皮120g、白术120g、僵蚕85g、荆芥120g、蝉蜕45g、防风120g、牛蒡子85g、厚朴120g、生地230g、当归120g、赤芍85g、桃仁120g、红花85g、熟地230g、独活75g、防己75g、川穹75g、羌活200g、白蒺藜75g、茯苓200g、元参120g、桂枝45g、何首乌200g、焦栀子7g、生甘草75g。
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CN106943557A (zh) * 2017-03-24 2017-07-14 成都海青生物科技有限公司 一种可有效治疗荨麻疹的丸剂药物及其制备方法

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