CN106266566A - 一种治疗颈椎病的丸剂药物及其制备方法 - Google Patents

一种治疗颈椎病的丸剂药物及其制备方法 Download PDF

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CN106266566A
CN106266566A CN201610813312.3A CN201610813312A CN106266566A CN 106266566 A CN106266566 A CN 106266566A CN 201610813312 A CN201610813312 A CN 201610813312A CN 106266566 A CN106266566 A CN 106266566A
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cervical spondylosis
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夏瑜
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Sichuan Jintang Haina Biomedical Technology Institute
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Abstract

本发明属于中药制剂领域,目的是根据中医对颈椎病的认识机理而提供的一种治疗颈椎病的丸剂药物,所述药物的各个组分及其质量份比如下:连翘60~150g、牡丹皮60~100g、川芎50~120g、肉苁蓉100~160g、薄荷40~120g、茯苓100~160g、厚朴30~120g、伸筋草90~160g、骨碎补100~200g、蒲黄50~100g、枸杞子100~200g、黄精150~250g、独一味30~60g、淫羊藿50~160g、红花50~120g、蒲公英100~300g、菊花80~180g、桔梗30~100g、桂枝20~70g、甘草30~150g,蜂蜜适量;本发明提供的药物是一个标本兼治的中药组方。

Description

一种治疗颈椎病的丸剂药物及其制备方法
技术领域
本发明属于中药制剂领域,具体涉及一种治疗颈椎病的丸剂药物,特别是供颈椎病患者使用的丸剂药物及其制备方法的领域。
背景技术
祖国医学认为:颈椎病又称颈椎综合征,是一种以退行性病理改变为基础的疾患,主要由于颈椎长期劳损、骨质增生,或椎间盘脱出、韧带增厚,致使颈椎脊髓、神经根或椎动脉受压,出现一系列功能障碍的临床综合征。颈椎病的临床表现有以下几种:⑴ 头颈活动受限,闭眼时向左右旋转头颈,引起偏头痛或眩晕;⑵ 颈部有僵直;⑶ 伴有手肩臂感觉异常疼痛手指无力;⑷ 由于颅内供血不足可引起脑后部缺血而表现一系列头部症状,如偏头痛、视力障碍、耳鸣、听力减退等;⑸ 有椎管狭窄者可在低头时突然引起全身麻木,或有过电样的感觉。随着现代人生活节奏的加快,白领一族需要在电脑前久坐,而平时又缺乏锻炼,就很容易引起颈椎病。
目前:治疗颈椎病的方法主要有:药物疗法、理疗法、牵引法、按摩法、针灸法等,但这些方法治疗疗程长,效果不够明显,以致于众多颈椎病患者长年颈肩疼痛、上肢麻木,肌肉无力,严重影响了生活质量。
那么,就如何找到一种可有效治疗颈椎病的中药组合物,是我们目前急需要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗颈椎病上,人们逐渐意识到了中医治疗颈椎病的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗颈椎病的现状,本发明的目的是在于提供一种治疗颈椎病的丸剂药物,以解决颈椎病患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述颈椎病。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗颈椎病的丸剂药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示。
连翘60~150g、牡丹皮60~100g、川芎50~120g、肉苁蓉100~160g、薄荷40~120g、茯苓100~160g、厚朴30~120g、伸筋草90~160g、骨碎补100~200g、蒲黄50~100g、枸杞子100~200g、黄精150~250g、独一味30~60g、淫羊藿50~160g、红花50~120g、蒲公英100~300g、菊花80~180g、桔梗30~100g、桂枝20~70g、甘草30~150g,蜂蜜适量。
一种治疗颈椎病的丸剂药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
连翘70~130g、牡丹皮70~85g、川芎60~100g、肉苁蓉115~140g、薄荷50~100g、茯苓115~140g、厚朴40~100g、伸筋草100~140g、骨碎补115~170g、蒲黄60~85g、枸杞子115~170g、黄精170~220g、独一味40~70g、淫羊藿60~140g、红花60~100g、蒲公英115~250g、菊花90~160g、桔梗40~85g、桂枝25~60g、甘草40~130g,蜂蜜适量。
一种治疗颈椎病的丸剂药物及其制备方法,其特征在于,所述“最佳方案”的药物的各个组分及其质量份比如下所示:
连翘110g、牡丹皮80g、川芎85g、肉苁蓉120g、薄荷85g、茯苓120g、厚朴85g、伸筋草120g、骨碎补150g、蒲黄75g、枸杞子150g、黄精20g、独一味60g、淫羊藿120g、红花85g、蒲公英220g、菊花140g、桔梗75g、桂枝50g、甘草120g,蜂蜜适量。
一种治疗颈椎病的丸剂药物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、除蜂蜜外,将上述原料中药拣去杂质和粉尘后,按照质量份比分别粉碎成粗粒状包煎;
B、⑴将包好的原料中药放入冷开水中浸泡1个半小时,然后再将浸泡好的药物和浸泡药物的澄清液一并放入煎锅内,加入过药36mm的冷开水进行第一次煎煮50分钟,滤取药液;⑵药渣中再次加入过药33mm的微温开水进行第二次煎煮45分钟,滤取药液;⑶将二次药液混合浓缩至糊状,然后干燥(80℃)、粉碎、过筛即得药粉;
C、按照传统制备中药蜜丸剂的方法,将研磨好的药粉放入无菌室中的药器中混合拌均,然后和蜂蜜调和,制备成蜜丸剂(其蜜丸的粒度为:4.9mm-5.0mm),干燥,分装密封即可。
一种治疗颈椎病的丸剂药物及其制备方法,其特征在于,所述服用方法为:将制备好的蜜丸剂药物以每日二次服用,早晚各服一次,给药量5g /次,饭后服(温开水送下),15天为一疗程,服药3~5疗程后,症状消失,获临床痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
连翘,性味:苦、性微寒,具有清热解毒、消肿散结、风热感冒之功效,用于治疗风热感冒、温病、热淋尿闭、痈疽、肿毒、瘰疬、瘿瘤、喉痹等症;
牡丹皮,性味:辛苦、凉、微寒,具有清热、活血散瘀之功效,用于治疗温热病热入血分、发斑、吐衄、热泪盈眶病菌后期热伏阴分发热、阴虚骨蒸潮热、血滞经闭、痛经、痈肿疮毒、跌扑伤痛、风湿热痹等症;
川芎,性味:辛、温,具有行气开郁、法风燥湿、活血止痛之功效,用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛等症;
肉苁蓉,性味:味甘、咸、性温,具有补肾阳、益精血、润肠道之功效,用于治疗肾阳虚衰、精血不足之阳痿、遗精、白浊、尿频余沥、腰痛脚弱、耳鸣目花、月经衍期、宫寒不孕、肠燥便秘等症;
薄荷,性味:辛、凉,具有疏风、散热、辟秽、解毒之功效,用于治疗外感风热、头痛、目赤、咽喉肿痛、食滞气胀、口疮、牙痛、疮疥、瘾疹等症;
茯苓,性味:甘、淡、平,具有渗湿利水、健脾和胃、宁心安神之功效,用于治疗小便不利、水肿胀满、痰饮咳逆、呕吐、脾虚食少、泄泻、心悸不安、失眠健忘、遗精白浊等症;
厚朴, 性味:苦、辛、温,具有燥湿消痰、下气除满之功效,用于治疗湿阻中焦、脘腹胀满、食积气滞、腹胀便秘、痰饮喘咳;
伸筋草,性味:苦、辛、温,无毒,具有祛风散寒、除湿消肿、舒筋活血、止咳、解毒之功效,用于治疗风寒湿痹、关节酸痛、皮肤麻木、四肢软弱、水肿、跌打损伤、黄疸、咳嗽、疮疡、疱疹、烫伤等病症;
骨碎补,性味:苦、性温,具有补肾强骨、活血止痛之功效,用于治疗肾虚腰痛、足膝痿弱、耳聋、牙痛、久泄、遗尿、跌打骨折及斑秃;
蒲黄,性味:味甘、微辛、性平,具有止血、祛瘀、利尿之功效,用于治疗吐血、咯血、衄血、备痢、便血、崩漏、外伤出血、心腹疼痛、经闭腹痛、产后瘀痛、痛经、跌扑肿痛、血淋涩痛、带下、重舌、口疮、聤耳、阴下湿痒等症;
枸杞子,性味:味甘、性平,具有养肝、滋肾、润肺之功效,用于治疗肝肾亏虚、头晕目眩、目视一清、腰膝酸软、阳痿贵精、虚劳咳嗽、消渴引饮等症;
黄精,性味:甘、平,具有补中益气、润心肺、强筋骨之功效,用于治疗虚损寒热、肺痨咳血、病后体虚食少、筋骨软弱、风湿疼痛,风癞癣疾等症;
独一味,性味:味甘、苦、性平,具有活血化瘀、消肿止痛之功效,用于治疗跌打、筋骨疼痛、关节肿痛、痛经、崩漏等症;
淫羊藿,性味:辛甘、温,具有补肾壮阳、祛风除湿之功效,用于治疗阳痿不举、小便淋沥、筋骨挛急、半身不遂、腰膝无力、风湿痹痛、四肢不仁等症;
红花,性味:味辛、性温,具有活血能经、祛瘀止痛之功效,用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛症瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症;
蒲公英,性味:味苦、甘、性寒,具有清热解毒、消痈散结之功效,用于治疗乳痈、肺痈、肠痈、痄腮、疔毒疮肿、目赤肿痛、感冒发热、咳嗽、咽喉肿痛、胃火、肠炎、痢疾、肝炎、胆吓炎、尿路感染、蛇虫咬伤等症;
菊花,性味:甘苦、凉,用于治疗疏风、清热、明目、解毒之功效,用于治疗头痛、眩晕、目赤、心胸烦热、疔疮、肿毒等症;
桔梗,性味:性平、味苦、辛,有小毒,具有祛痰、利咽、宣肺、排脓、利五脏、补气血、补五劳、养气之功效,用于主治咽喉肿痛、肺痈吐脓、咳嗽痰多、痢疾腹痛、胞满胁痛、口舌生疮、赤目肿痛、小便癃闭等病症;
桂枝,性味:辛、甘、性温,具有散寒解表、温通经脉、通阳化气之功效,用于治疗风寒表证、寒湿痹痛、四肢厥冷、经闭痛经、症瘕结块、胸痹、心悸、痰饮、小便不利等症;
甘草,性味:甘、平,具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效,用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒等症。
本发明药物是基于中医治疗颈椎病的辨病与辨证相结合的原则,从药理作用及作用机制认为:就颈椎病一证,本发明所提供的药物中的各原料中药药效共奏,对上述颈椎病有很好的治疗效果。
具体实施方式
本发明就是针对上述颈椎病的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个标本兼治的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述。
实施例1:
一种治疗颈椎病的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
连翘110g、牡丹皮80g、川芎85g、肉苁蓉120g、薄荷85g、茯苓120g、厚朴85g、伸筋草120g、骨碎补150g、蒲黄75g、枸杞子150g、黄精20g、独一味60g、淫羊藿120g、红花85g、蒲公英220g、菊花140g、桔梗75g、桂枝50g、甘草120g,蜂蜜适量。
实施例2:
一种治疗颈椎病的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
连翘130g、牡丹皮85g、川芎100g、肉苁蓉140g、薄荷100g、茯苓140g、厚朴100g、伸筋草140g、骨碎补170g、蒲黄85g、枸杞子170g、黄精220g、独一味70g、淫羊藿140g、红花100g、蒲公英250g、菊花160g、桔梗85g、桂枝60g、甘草130g,蜂蜜适量。
实施例3:
一种治疗颈椎病的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
连翘150g、牡丹皮100g、川芎120g、肉苁蓉160g、薄荷120g、茯苓160g、厚朴120g、伸筋草160g、骨碎补200g、蒲黄100g、枸杞子200g、黄精250g、独一味60g、淫羊藿160g、红花120g、蒲公英300g、菊花180g、桔梗100g、桂枝70g、甘草150g,蜂蜜适量。
典型病例
经临床诊断治疗颈椎病患者共705例,年龄为41岁以上的470例,只有235例为41岁以下。705例患者中痊愈的685例,显效的20例,总有效率达100%。

Claims (3)

1.一种治疗颈椎病的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
连翘60~150g、牡丹皮60~100g、川芎50~120g、肉苁蓉100~160g、薄荷40~120g、茯苓100~160g、厚朴30~120g、伸筋草90~160g、骨碎补100~200g、蒲黄50~100g、枸杞子100~200g、黄精150~250g、独一味30~60g、淫羊藿50~160g、红花50~120g、蒲公英100~300g、菊花80~180g、桔梗30~100g、桂枝20~70g、甘草30~150g,蜂蜜适量。
2.根据权利要求1所述的治疗颈椎病的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
连翘70~130g、牡丹皮70~85g、川芎60~100g、肉苁蓉115~140g、薄荷50~100g、茯苓115~140g、厚朴40~100g、伸筋草100~140g、骨碎补115~170g、蒲黄60~85g、枸杞子115~170g、黄精170~220g、独一味40~70g、淫羊藿60~140g、红花60~100g、蒲公英115~250g、菊花90~160g、桔梗40~85g、桂枝25~60g、甘草40~130g,蜂蜜适量。
3.根据权利要求1至2所述的治疗颈椎病的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
连翘110g、牡丹皮80g、川芎85g、肉苁蓉120g、薄荷85g、茯苓120g、厚朴85g、伸筋草120g、骨碎补150g、蒲黄75g、枸杞子150g、黄精20g、独一味60g、淫羊藿120g、红花85g、蒲公英220g、菊花140g、桔梗75g、桂枝50g、甘草120g,蜂蜜适量。
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