CN105381127A - 一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法 - Google Patents

一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法 Download PDF

Info

Publication number
CN105381127A
CN105381127A CN201510970156.7A CN201510970156A CN105381127A CN 105381127 A CN105381127 A CN 105381127A CN 201510970156 A CN201510970156 A CN 201510970156A CN 105381127 A CN105381127 A CN 105381127A
Authority
CN
China
Prior art keywords
parts
chinese medicine
radix
blood
traditional chinese
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510970156.7A
Other languages
English (en)
Inventor
陈玉华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201510970156.7A priority Critical patent/CN105381127A/zh
Publication of CN105381127A publication Critical patent/CN105381127A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/583Snakes; Lizards, e.g. chameleons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/15Pinaceae (Pine family), e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明公开了一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法,属中药领域。本发明药物有效成分的原料组成为:牛奶柴、当归、杠香藤、节节茶、大红菇、黄芪、黑豆衣、夜交藤、海松子、熟地、木通根、川桂皮、走游草、大枣、木天蓼子、甘草、乌梢蛇、元胡、红毛七、石菖蒲。本发明选用药材的药性相适相辅,针对病因对症下药,有补气固表、养血祛风、补血活血、活血散瘀、温经散寒、祛风通络、行气活血、解毒消肿之功效,吸收效果好,疗效显著,无毒副作用及临床不良反应,经临床验证对周围性面瘫治愈率较高。

Description

一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法
所属技术领域
本发明涉及中药领域,尤其涉及一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法。
背景技术
周围性面瘫为临床最常见的面肌麻痹,表现为同侧面部所有表情肌的弛缓性瘫痪,面神经受损部位在面神经核或面神经核以下。多数病人往往于清晨洗脸、漱口时突然发现一侧面颊动作不灵、嘴巴歪斜。前额皱纹消失、眼裂扩大、鼻唇沟平坦、口角下垂,露齿时口角向健侧偏歪。鼓腮和吹口哨时,因患侧口唇不能闭合而漏气。进食时,食物残渣常滞留于病侧的齿颊间隙内,并常有口水自该侧淌下。病初多有耳周疼痛;可伴有患侧舌前2/3味觉减退;听力过敏、听力下降等等。
周围性面瘫与面神经损伤有关。面神经是人体内居于骨管中最长的神经,也是最容易受到损害的神经。“周围性面瘫病因较为复杂,因为面神经很长,比较容易受累,其行走经络的任何病变都可导致面瘫。”在很多人看来,能患上周围性面瘫的人都是年老体弱者。实际上,年轻人也可能患上面瘫。“有些年轻人喜欢通宵上网,有的白领则是需要工作到很晚,这时面瘫也可能找上门来。
目前针灸治疗周围性面瘫作为有效治疗手段之一已被广泛应用,并为广大患者接受,具有较好的疗效,并且安全无副作用。因此针灸疗法治疗周围性面瘫已被列为针灸治疗优势病种之一。
中医认为周围性面瘫是因人体正气不足,卫外不固,面部脉络空虚,风寒等外邪乘虚侵袭,气血痹阻,经脉失养,颜面肌肉纵缓不收而发生口眼歪斜。针灸治疗虽能够有效改善局部组织的水肿、充血、渗出、粘连、挛缩、缺血等病理变化,从而加快血液循环,促进代谢,使病变组织和神经重新修复,对周围性面瘫有很好的治疗效果,但一般治疗周期长,针灸次数过多,患者易产生恐惧心理,配合度降低,影响治疗效果。因此本发明根据长期临床实践,采用中药内服来辅助针灸进行治疗,减少了针灸次数,缩短了治疗周期,疗效更为显著。本发明中药根据病因对症下药,具有补气固表、养血祛风、补血活血、活血散瘀、温经散寒、祛风通络、行气活血、解毒消肿之功效,与针灸治疗相辅相成,加强针灸治疗效果,使局部血液循环营养状态得以更快更好的改善,标本兼治,疗效好,见效快。无毒副作用及临床不良反应,经临床验证对周围性面瘫治愈率较高。
发明内容
本发明提供了一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法,具有补气固表、养血祛风、补血活血、活血散瘀、温经散寒、祛风通络、行气活血、解毒消肿之功效,治病求源标本兼治,对各种原因引起的周围性面瘫均具有很好的疗效。
为实现上述目的,本发明的技术方案实施如下:
一种辅助针灸治疗周围性面瘫的中药冲剂,制成所述药物有效成分的原料组成及重量份数为:
牛奶柴60~75份、当归57~72份、杠香藤54~68份、节节茶50~65份、
大红菇46~61份、黄芪43~58份、黑豆衣40~54份、夜交藤37~50份、
海松子33~47份、熟地30~44份、木通根27~40份、川桂皮24~37份、
走游草20~33份、大枣18~30份、木天蓼子15~27份、甘草12~23份、
乌梢蛇8~20份、元胡5~16份、红毛七3~13份、石菖蒲1~10份。
制成所述药物有效成分的原料组成及重量份数为:
牛奶柴64~71份、当归60~68份、杠香藤57~65份、节节茶54~61份、
大红菇50~58份、黄芪46~55份、黑豆衣43~51份、夜交藤40~47份、
海松子36~44份、熟地33~40份、木通根30~37份、川桂皮27~34份、
走游草23~30份、大枣20~26份、木天蓼子18~24份、甘草15~20份、
乌梢蛇10~16份、元胡8~13份、红毛七5~10份、石菖蒲3~7份。
制成所述药物有效成分的原料组成及重量份数为:
牛奶柴68份、当归64份、杠香藤61份、节节茶58份、
大红菇54份、黄芪50份、黑豆衣47份、夜交藤44份、
海松子40份、熟地36份、木通根33份、川桂皮30份、
走游草27份、大枣24份、木天蓼子21份、甘草17份、
乌梢蛇13份、元胡10份、红毛七7份、石菖蒲4份。
一种辅助针灸治疗周围性面瘫的中药冲剂的制备方法,包括以下工艺步骤:
(1)将牛奶柴、杠香藤、节节茶、大红菇、黑豆衣、夜交藤、海松子、川桂皮、大枣、木天蓼子、甘草、石菖蒲洗净、晾干后混合均匀,放入容器中,在容器中加入6~8倍量的水,加热煮沸2~3小时,冷却后取浸液;在剩余的药渣中再加入4~6倍量的水,加热煮沸1~2小时,冷却后取浸液;合并两次所得浸液,加热,蒸发浓缩为相对密度1.15~1.25的稠膏,备用;
(2)将当归、熟地、木通根、走游草、红毛七放入容器中,加入3~5倍量的绍兴黄酒,煮沸后放凉,继续浸泡3~5小时,取浸液;在剩余的药渣中再加入2~4倍量的绍兴黄酒,煮沸后放晾,继续浸泡2~4小时,取浸液;合并两次所得浸液,加蒸蒸发浓缩为相对密度1.10~1.20的稠膏,备用;
(3)将黄芪片加炼熟的蜂蜜与少许开水,拌匀稍闷,放锅内炒至黄色并不粘手时,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(4)取净乌梢蛇段,按酒炙法炒干,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(5)取净元胡,用醋拌匀,浸润,至醋吸尽,置锅内用文火炒至微干,取出,放凉,筛去碎屑,粉碎研末,过100目细筛,得细粉,备用;
(6)将步骤(1)、步骤(2)所得的稠膏,与步骤(3)、步骤(4)、步骤(5)中所得的细粉混合,加辅料蔗糖和糊精混合均匀制成颗粒,干燥、整粒后,封装成每袋10g的中药冲剂。
本发明所用中药的药性如下:
牛奶柴:味甘;淡;性温。归肺;脾;肾经。补中健脾;祛风湿;活血通络。主治气虚乏力;四肢酸软;风湿痹痛;筋骨不利;跌打损伤;经闭;乳汁不通。
当归:味甘;辛;性温。归肝、心、脾经。补血活血;调经止痛;润肠通便。主治血虚萎黄;眩晕心悸;虚寒腹痛;风湿痹痛;跌扑损伤;痈疽疮疡。《本草正》载:“其味甘而重,故专能补血,其气轻而辛,故又能行血,能养营养血,补气生精,安五脏,强形体,益神志,凡有形虚损之病,无所不宜。”现代医学研究证实,当归具有抗菌、消炎作用,对慢性风湿关节炎急性发作有明显的抑制作用。
杠香藤:味苦;辛;性温。归心;肝;脾经。祛风除湿;活血通络;解毒消肿;驱虫止痒。主治风湿痹证;腰腿疼痛;口眼歪斜;跌打损伤;痈肿疮疡;绦虫病;湿疹;顽癣;蛇犬咬伤。
节节茶:味辛;微苦;性温。祛风散寒;通经活络;止血。主治风寒感冒;头痛;风湿痹痛;肢体麻木;损伤骨析;产后流血。
大红菇:味甘;性微温。养血;逐瘀;祛风。主治血虚萎黄;产后恶露不尽;关节酸痛。
黄芪:味甘;性温。入心;肺;脾;肾经。补气固表;利尿;托毒排脓;生肌敛疮。主治气短心悸;倦怠;乏力;自汗;盗汗;久泻;脱肛;体虚浮肿;子宫脱垂;慢性肾炎;痈疽难溃;或溃久不敛。《新华本草纲要》载:“有补气固表、托毒排脓、生肌的功能。”现代医学研究证实,黄芪主要成分为黄芪总黄酮、黄芪总多糖、黄芪总皂苷和氨基酸等,具有利尿降压、消炎镇痛、强心、抗氧自由基生成及提高机体免疫功能等多种药理作用,可从多方面作用于机体,改善心血管、脑血管、糖尿病、肾病等相关血管性病变患者的血流动力学和血管内皮细胞等功能。
黑豆皮:养血祛风。主治阴虚盗汗、虚热、烦躁、头晕目昏,血寒,风痹。
夜交藤:味甘;微苦;性平。入心;肝经。养心安神;祛风;通络。主治失眠;多梦;血虚身痛;肌肤麻木;风湿痹痛;风疹瘙痒。《饮片新参》载:“养肝肾,止虚汗,安神催眠,补中气,行经络,通血脉,治劳伤。”现代医学研究证实,夜交藤含有大黄素、大黄素甲醚,与戊巴比妥钠呈协同作用,有显著的镇静、催眠作用,尤其是延长慢波睡眠时相。
海松子:味甘;性微温。归肝;肺;大肠经。润燥,养血,祛风。主治肺燥干咳,大便虚秘,诸风头眩,骨节风,风痹。并有润泽皮肤,敷荣毛发的功能。《日华子本草》:逐风痹寒气,虚羸少气,补不足,润皮肤,肥五脏。
熟地:味甘;性温;归肝;肾经。补血滋润;益精填髓。主治血虎萎黄;眩晕心悸;肝肾阴亏;腰膝酸软;肾虚喘促。《本草汇言》载:“久病阴伤,新产血败,在所必需者也。”现代医学研究证实,熟地可增强GSH-Px活性,降低血清中LPO的含量,提高血浆AD浓度,此外与骨髓造血系统亦有密切相关的作用。
木通根:味苦;性平;归肝;肾经。祛风通络;利水消肿;行气活血;补肝肾;强筋骨。主治风湿痹痛;跌打损伤;经闭;疝气;睾丸肿痛;脘腹胀闷;小便不利;带下;虫蛇咬伤。《浙江民间常用草药》:祛风止痛,行气活血,利尿解毒。
川桂皮:味辛;甘;性温。温经散寒;行气活血;止痛。主治:风寒感冒;胃脘冷痛;痛经;风湿关节疼痛;跌打损伤;骨折。
走游草:味辛;性温。归肝;脾;肾经。祛风除湿;活血通络;解毒消肿。主治风湿痹痛;跌打损伤;流注痰核;痈疮肿毒;毒蛇咬伤。《四川中药志》:发散风湿,行血导滞。治头痛、身痛、筋骨痛、风湿麻木及流注;外用洗疮毒。
大枣:味甘;温。归脾;胃经。补脾胃;益气血;安心神;调营卫;和药性。主治脾胃虚弱;气血不足;食少便溏;倦怠乏力;心悸失眠;妇人脏躁;营卫不和。《本草汇言》:沈氏曰,此药甘润膏凝,善补阴阳、气血、津液、脉络、筋俞、骨髓,一切虚损,无不宜之。如龙谭方治惊悸怔忡,健忘恍惚,志意昏迷,精神不守,或中气不和,饮食无味,百体懒重,肌肉瘦,此属心、脾二藏元神亏损之证,必用大枣治之。佐用陈皮,调畅中脘虚滞之痰。
木天蓼子:味辛;苦;性温。归肝;肾经。祛风通络;活血行气;散寒止痛。主治中风口面歪斜;痃癖腹痛;疝气。《药性论》:"治中贼风,口面歪斜,主冷痃癖气块,女子虚劳。"
甘草:味甘;性平。归心;肺;脾;胃经。补脾益气;清热解毒;祛痰止咳;缓急止痛;调和诸药。主治脾胃虚弱;倦怠乏力;心悸气短;咳嗽痰多;脘腹四脚挛急疼痛;痈肿疮毒;缓解药物毒性。《本草纲目》载:“诸药中甘草为君。治七十二种乳石毒,解一千二百般草本毒,调和从药有功。”现代医学研究证实,甘草有较强的解毒作用,还有抗溃疡、抗炎症、镇痉镇咳、降血压、降血脂、抗癌作用,广泛用于治疗咽喉炎、喉炎、气管炎、支气管炎、哮喘、咳嗽、咳血等疾病,此外还具有抗胃溃疡、抗胃炎作用。
乌梢蛇:味甘;性平。入肝;肾经。祛风湿;通经络;止痉。主治风湿顽痹,麻木拘挛,中风口眼歪斜,半身不遂,抽搐痉挛,破伤风,麻风疥癣,瘰疬恶疮。《纲目》载:“治风毒气,眼生翳,唇紧、唇疮。”现代医学研究证实,乌梢蛇能抑制琼脂性关节肿胀和二甲苯性炎症,醇提液对不同程度的热刺激和化学性疼痛有一定的镇静、镇痛作用。
元胡:味辛;苦;性温;无毒。入肝;胃;心;肺;脾经。活血;散瘀;理气;止痛。主治心腹腰膝诸痛;月经不调;症瘕;崩中;产后血晕;恶露不尽;跌打损伤。《纲目》载:“能行血中气滞,气中血滞,故专治一身上下诸痛,用之中的,妙不可言。活血,利气,止痛,通小便。”现代医学研究表明,元胡有显著的镇痛、镇静、催眠、安定作用,兴奋胃肠平滑肌,显著扩张冠状血管,能引起垂体促肾上腺皮质激素的分泌,对肌肉有松驰作用。
红毛七:味苦、辛,性温。归肝;胃经。活血散瘀;祛风除湿;行气止痛。主治:月经不调;痛经;产后血瘀腹痛;脘腹寒痛;跌打损伤,风湿痹痛。《陕西中草药》:活血散瘀,祛风止痛,降血压,止血,解草乌中毒。治月经不调,经期少腹疼痛,产后瘀血疼痛,关节炎,劳伤,扁桃体炎,高血压。现代医学研究证明:红毛七提取剂能收缩子宫,对血管也有收缩作用;所含塔斯品碱有显著的抑菌作用。
石菖蒲:味辛;苦;性微温。归心;肝;脾经。化痰开窍;化湿行气;祛风利痹;消肿止痛。主治热病神昏;痰厥;健忘;耳鸣;耳聋;脘腹胀痛;噤口痢;风湿痹痛;跌打损伤;痈疽疥癣。《重庆堂随笔》:石菖蒲,舒心气、畅心神、怡心情、益心志,妙药也。清解药用之,赖以祛痰秽之浊而卫宫城,滋养药用之,借以宣心思之结而通神明。
本发明与现有技术相比,具有以下有益效果:
本发明选用药材的药性相适相辅,针对病因对症下药,有补气固表、养血祛风、补血活血、活血散瘀、温经散寒、祛风通络、行气活血、解毒消肿之功效,吸收效果好,疗效显著,无毒副作用及临床不良反应,经临床验证对周围性面瘫治愈率较高。
具体实施方式
下面结合具体实施例对本发明做进一步阐述。
实施例1
本发明药物有效成分的原料组成及重量为:
牛奶柴60~75份、当归57~72份、杠香藤54~68份、节节茶50~65份、
大红菇46~61份、黄芪43~58份、黑豆衣40~54份、夜交藤37~50份、
海松子33~47份、熟地30~44份、木通根27~40份、川桂皮24~37份、
走游草20~33份、大枣18~30份、木天蓼子15~27份、甘草12~23份、
乌梢蛇8~20份、元胡5~16份、红毛七3~13份、石菖蒲1~10份。
本发明药物制备方法的工艺步骤为:
(1)将牛奶柴、杠香藤、节节茶、大红菇、黑豆衣、夜交藤、海松子、川桂皮、大枣、木天蓼子、甘草、石菖蒲洗净、晾干后混合均匀,放入容器中,在容器中加入6~8倍量的水,加热煮沸2~3小时,冷却后取浸液;在剩余的药渣中再加入4~6倍量的水,加热煮沸1~2小时,冷却后取浸液;合并两次所得浸液,加热,蒸发浓缩为相对密度1.15~1.25的稠膏,备用;
(2)将当归、熟地、木通根、走游草、红毛七放入容器中,加入3~5倍量的绍兴黄酒,煮沸后放凉,继续浸泡3~5小时,取浸液;在剩余的药渣中再加入2~4倍量的绍兴黄酒,煮沸后放晾,继续浸泡2~4小时,取浸液;合并两次所得浸液,加蒸蒸发浓缩为相对密度1.10~1.20的稠膏,备用;
(3)将黄芪片加炼熟的蜂蜜与少许开水,拌匀稍闷,放锅内炒至黄色并不粘手时,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(4)取净乌梢蛇段,按酒炙法炒干,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(5)取净元胡,用醋拌匀,浸润,至醋吸尽,置锅内用文火炒至微干,取出,放凉,筛去碎屑,粉碎研末,过100目细筛,得细粉,备用;
(6)将步骤(1)、步骤(2)所得的稠膏,与步骤(3)、步骤(4)、步骤(5)中所得的细粉混合,加辅料蔗糖和糊精混合均匀制成颗粒,干燥、整粒后,封装成每袋10g的中药冲剂。
用法用量:每日3次每次1袋,饭前半小时以开水冲服,7天为1个疗程。、
实施例2
本发明药物有效成分的原料组成及重量为:
牛奶柴64~71份、当归60~68份、杠香藤57~65份、节节茶54~61份、
大红菇50~58份、黄芪46~55份、黑豆衣43~51份、夜交藤40~47份、
海松子36~44份、熟地33~40份、木通根30~37份、川桂皮27~34份、
走游草23~30份、大枣20~26份、木天蓼子18~24份、甘草15~20份、
乌梢蛇10~16份、元胡8~13份、红毛七5~10份、石菖蒲3~7份。
本实施例的药物制备方法工艺步骤及用法用量与实施例1相同。
实施例3
本发明药物有效成分的原料组成及重量为:
牛奶柴68份、当归64份、杠香藤61份、节节茶58份
大红菇54份、黄芪50份、黑豆衣47份、夜交藤44份
海松子40份、熟地36份、木通根33份、川桂皮30份
走游草27份、大枣24份、木天蓼子21份、甘草17份
乌梢蛇13份、元胡10份、红毛七7份、石菖蒲4份。
本实施例的药物制备方法工艺步骤及用法用量与实施例1相同。
临床资料:
1、病例选择
选择我院或外院确诊的周围性面瘫患者72例临床观察,病人随机分成两组。治疗组36例,其中男性19例,女性17例,年龄15~59岁,平均年龄31.6岁,病程最短者1天,最长者3个月。对照组36例,其中男性20例,女性16例,年龄16~57岁,平均年龄31.4岁,病程最短者1天,最长者3个月。两组患者病历基本一致,无显著差异,具有可比性。
2、治疗组患者除根据病况对症予以针灸治疗外,另外加服本发明药物,每日3次每次1袋,饭前半小时以开水冲服,7天为1个疗程,服用3个疗程。对照组根据诊断出的周围性面瘫的病况,对症予以针灸治疗。
3、疗效判定:
(1)治愈:患者面神经运动功能恢复正常,患侧、健侧面部肌肉对称,患侧眼睑闭合完全,鼻唇沟基本对称,口角无歪斜。
(2)好转:患者面神经运动功能大部分恢复,患侧眼睑能闭合,静止时面部外观正常,鼻唇沟稍浅,笑时口角略有歪斜。
(3)无效:症状同施治前无明显差异。
4、结果
治疗组治愈率77.8%、总有效率97.2%,对照组治愈率61.1%、总有效率94.4%,两组疗效比较,差异具有统计学意义(P<0.05),故治疗组对于本病的疗效明显优于对照组。
表1两组患者临床疗效比较
典型病例举例:
1、张××,男,43岁。该患者早上起床时,感觉左侧面部不适,口眼向右侧歪斜,左眼无法闭合,喝水时顺口角往外漏水。后来来院问诊,诊断为周围性面瘫,经对症予以针灸治疗,并服用本发明中药冲剂1个疗程后,上述症状完全消失,左眼闭合正常,面部表情协调,病情痊愈。
2、蔡××,女,26岁。患者因患风寒感冒,次日起床时感觉右侧面部不适,说话时口角略微向右侧歪斜,右眼闭合不全,迎风有流泪,不能鼓腮,口角有漏水现象。后来来院问诊,诊断为周围性面瘫,经对症予以针灸治疗,并服用本发明中药冲剂2个疗程后,上述症状完全消失,右眼闭合正常,面部表情协调,鼓腮正常,病情痊愈。
3、孙××,女,23岁。患者早起刷牙时发现左侧面部不适,嘴角向右歪斜。左眼闭合不全,不能皱眉,不能鼓腮,吐字不清,口角流口水。后来来院问诊,诊断为周围性面瘫,经对症予以针灸治疗,并服用本发明中药冲剂1个疗程后,上述症状基本消失,遵医嘱继续服用1个疗程后,上述症状完全消失,右眼闭合正常,面部表情协调,鼓腮有力,吐字清晰,说话流利,病情痊愈。
在临床中周围性面瘫是一种常见病,本病起病急骤,如及早治疗,则效果很好,如病程延长或失治,则不易治愈。本病多由络脉空虚,风寒之邪乘虚侵袭阳明、少阳两经,以致经气阻滞,闭阻气血,肌肉经脉失于濡养,筋肉纵缓不收而发病,本发明根据原因,对症下药,方中黄芪可补气固表;方中当归、熟地可补血活血;方中大红菇、黑豆衣、海松子可养血祛风;方中大枣可益气血、调营卫;方中元胡、红毛七可活血散瘀;方中石菖蒲可化痰开窍、祛风利痹;方中乌梢蛇可祛风止痉;方中川桂皮可温经散寒;方中牛奶柴、杠香藤、走游草可祛风除湿、活血通络、解毒消肿;方中节节茶、木通根、夜交藤、木天蓼子可祛风通络、行气活血;方中甘草可调和诸药;方中诸药共用,具有补气固表、养血祛风、补血活血、活血散瘀、温经散寒、祛风通络、行气活血、解毒消肿之功效,同时配合针灸疏通面部经络气血,使药力径走头面经络,直达病所,使局部血液循环营养状态得以更快更好的改善,吸收效果好,疗效显著,无毒副作用及临床不良反应,经临床验证对周围性面瘫治愈率较高。

Claims (4)

1.一种辅助针灸治疗周围性面瘫的中药冲剂,其特征在于:制成所述药物有效成分的原料组成及重量份数为:
2.根据权利要求1所述的一种辅助针灸治疗周围性面瘫的中药冲剂,其特征在于:制成所述药物有效成分的原料组成及重量份数为:
3.根据权利要求1所述的一种辅助针灸治疗周围性面瘫的中药冲剂,其特征在于:制成所述药物有效成分的原料组成及重量份数为:
4.一种辅助针灸治疗周围性面瘫的中药冲剂的制备方法,其特征在于:包括以下工艺步骤:
(1)将牛奶柴、杠香藤、节节茶、大红菇、黑豆衣、夜交藤、海松子、川桂皮、大枣、木天蓼子、甘草、石菖蒲洗净、晾干后混合均匀,放入容器中,在容器中加入6~8倍量的水,加热煮沸2~3小时,冷却后取浸液;在剩余的药渣中再加入4~6倍量的水,加热煮沸1~2小时,冷却后取浸液;合并两次所得浸液,加热,蒸发浓缩为相对密度1.15~1.25的稠膏,备用;
(2)将当归、熟地、木通根、走游草、红毛七放入容器中,加入3~5倍量的绍兴黄酒,煮沸后放凉,继续浸泡3~5小时,取浸液;在剩余的药渣中再加入2~4倍量的绍兴黄酒,煮沸后放晾,继续浸泡2~4小时,取浸液;合并两次所得浸液,加蒸蒸发浓缩为相对密度1.10~1.20的稠膏,备用;
(3)将黄芪片加炼熟的蜂蜜与少许开水,拌匀稍闷,放锅内炒至黄色并不粘手时,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(4)取净乌梢蛇段,按酒炙法炒干,取出放凉,粉碎研末,过100目细筛,得细粉,备用;
(5)取净元胡,用醋拌匀,浸润,至醋吸尽,置锅内用文火炒至微干,取出,放凉,筛去碎屑,粉碎研末,过100目细筛,得细粉,备用;
(6)将步骤(1)、步骤(2)所得的稠膏,与步骤(3)、步骤(4)、步骤(5)中所得的细粉混合,加辅料蔗糖和糊精混合均匀制成颗粒,干燥、整粒后,封装成每袋10g的中药冲剂。
CN201510970156.7A 2015-12-21 2015-12-21 一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法 Pending CN105381127A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510970156.7A CN105381127A (zh) 2015-12-21 2015-12-21 一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510970156.7A CN105381127A (zh) 2015-12-21 2015-12-21 一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法

Publications (1)

Publication Number Publication Date
CN105381127A true CN105381127A (zh) 2016-03-09

Family

ID=55414303

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510970156.7A Pending CN105381127A (zh) 2015-12-21 2015-12-21 一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法

Country Status (1)

Country Link
CN (1) CN105381127A (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105663365A (zh) * 2016-04-01 2016-06-15 青岛智信天成科技发展有限公司 一种用于麻醉术后瘙痒疼痛缓解的中药冲剂及制备方法
CN110433278A (zh) * 2019-07-17 2019-11-12 李卫 一种用于治疗面部神经炎的含有大麻二酚的组合物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103638250A (zh) * 2013-12-23 2014-03-19 李宣东 一种治疗面神经麻痹的中药制剂及其制备方法
CN103893294A (zh) * 2014-04-22 2014-07-02 谭展玉 一种治疗周围性面瘫的中药组合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103638250A (zh) * 2013-12-23 2014-03-19 李宣东 一种治疗面神经麻痹的中药制剂及其制备方法
CN103893294A (zh) * 2014-04-22 2014-07-02 谭展玉 一种治疗周围性面瘫的中药组合物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105663365A (zh) * 2016-04-01 2016-06-15 青岛智信天成科技发展有限公司 一种用于麻醉术后瘙痒疼痛缓解的中药冲剂及制备方法
CN110433278A (zh) * 2019-07-17 2019-11-12 李卫 一种用于治疗面部神经炎的含有大麻二酚的组合物及其制备方法

Similar Documents

Publication Publication Date Title
CN101543610B (zh) 一种有效治疗痛经的药酒
CN105250887A (zh) 用于icu重症肌无力治疗与护理的中药冲剂及制备方法
CN103536778B (zh) 一种治疗偏头痛的中药制剂
CN102366468A (zh) 一种治疗白癜风的中药
CN104069474A (zh) 一种治疗脂溢性脱发的中药组合物及其制备方法
CN101642548B (zh) 治疗腰腿疼痛的中药膏贴及其制备方法
CN104784415A (zh) 一种用治疗急性出疹性传染疾病的中药丸剂及制备方法
CN103977306A (zh) 一种治疗乙型肝炎的药物及其制备方法
CN105381127A (zh) 一种辅助针灸治疗周围性面瘫的中药冲剂及制备方法
CN104189527A (zh) 一种治疗脱发的中药药剂
CN103800697A (zh) 治疗咽炎的中药组合物
CN102366469A (zh) 一种治疗白癜风的药物
CN105999110A (zh) 一种用于治疗女性慢性盆腔疼痛的中药冲剂及制备方法
CN105381128A (zh) 一种辅助针灸治疗外周神经麻痹的中药冲剂及制备方法
CN105250569A (zh) 一种用于治疗末梢神经炎的中药丸剂及制备方法
CN104800610A (zh) 一种治疗帕金森病的中药制剂及其制备方法
CN103610916B (zh) 一种治疗动脉硬化的中药制剂
CN105663365A (zh) 一种用于麻醉术后瘙痒疼痛缓解的中药冲剂及制备方法
CN106266566A (zh) 一种治疗颈椎病的丸剂药物及其制备方法
CN106139111A (zh) 一种可有效治疗抑郁症的中药组合物及其制备方法
CN105688074A (zh) 一种治疗少腹痛的汤剂药物及其制备方法
CN105770354A (zh) 一种用于治疗慢性肾炎的药物及制备方法
CN105477515A (zh) 一种治疗缺乳的药物及其制备方法
CN104288398A (zh) 一种治疗痰湿瘀结型子宫肌瘤的中药及制备方法
CN105125860A (zh) 一种有效治疗骨质疏松的制剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20160309

RJ01 Rejection of invention patent application after publication