CN106214593B

CN106214593B - Moisturizing liquid containing nano activated carbon and preparation method thereof

Info

Publication number: CN106214593B
Application number: CN201610855689.5A
Authority: CN
Inventors: 李力
Original assignee: GUIZHOU TELIDA NANO CARBON SCIENCE & TECHNOLOGY Co Ltd
Current assignee: GUIZHOU TELIDA NANO CARBON SCIENCE & TECHNOLOGY Co Ltd
Priority date: 2016-09-28
Filing date: 2016-09-28
Publication date: 2020-03-24
Anticipated expiration: 2036-09-28
Also published as: CN106214593A

Abstract

The invention discloses a moisturizing liquid containing nano activated carbon, which mainly comprises the following components in parts by weight: 0.01-0.1 part of nano activated carbon, 3.2-5 parts of micromolecular hyaluronic acid, 0.3-2 parts of lecithin liposome, 100.6-1.2 parts of coenzyme Q, 4-16 parts of glycerol, 5-8 parts of propylene glycol, 0.2-1.5 parts of rose extract, 0.3-1.5 parts of allantoin, 0.3-0.8 part of amino acid humectant, 0.1-0.5 part of VE, 0.05-1 part of wheat germ extract, 0.05-0.1 part of linseed oil, 400.1-0.3 part of PEG and 30-80 parts of purified water. The moisturizing liquid is suitable for all types of skin, is particularly suitable for skin repair, moisturizing and moisturizing after micro-needles, phototherapy and various instrument treatments, and makes nutrient substances more easily enter the skin by utilizing a high-end liposome technology, so that the effects of quick repair, moisturizing and long-acting moisturizing are achieved, and roughness, fine wrinkles and dryness are improved.

Description

Moisturizing liquid containing nano activated carbon and preparation method thereof

Technical Field

The invention relates to the technical field of skin care products, in particular to moisturizing liquid containing nano activated carbon and a preparation method thereof.

Background

With the ever-improving economic and living standards, the basic care of skin has become a part of daily life. Good skin is mainly manifested in various aspects of complexion, elasticity, luster, texture and physiological function, and what plays a critical role in these is the moisture content of the skin. Generally, the epidermis and dermis have a water content of about 75%, the outermost stratum corneum layer should generally be no less than 10%, and skin with a water content of 10-20% will exhibit a soft, smooth, elastic texture, while below 10%, the stratum corneum layer will be too dry and even appear to scale or break. Therefore, deep moisturizing of the skin is the fundamental guarantee for obtaining healthy and beautiful skin. Although different moisturizing products are in various types on the market, most moisturizing skin care products can only replenish moisture content outside the epidermis, increase the content of water and oil on the surface layer of the skin, but cannot deeply improve the moisture content of the cortex, and thus cannot radically improve the dryness of the skin.

Secondly, for skin treated by micro-needles, phototherapy and various instruments, including wounds, micro-wounds, non-wounds and the like, postoperative repair is needed, on one hand, bacteria are killed, and scar hyperplasia is prevented, on the other hand, repair of the epidermis and the dermis of the surface of the skin wound is needed, and melanin formation is inhibited, but no skin care product with special quick effect is available at present, and the skin repair, water supplement and moisture preservation functions are integrated, so that the skin repair is specially used for skin repair after treatment of various instruments.

In addition, although a plurality of skin care products which become multiple effects exist at present, actual research effects show that the skin care products have simple superposition effects and do not have obvious improvement effects on a plurality of skin problems. In addition, in some skin care products, substances harmful to human bodies, such as heavy metals, are added to achieve a whitening effect.

Therefore, the invention aims to develop the moisturizing liquid containing the nano activated carbon, and the moisturizing liquid has the dense repairing effect while deeply moisturizing.

Disclosure of Invention

The invention solves the technical problem of providing the moisturizing liquid containing the nano activated carbon and the preparation method thereof, and the moisturizing liquid has the dense repairing function while deeply moisturizing.

The technical scheme of the invention is as follows:

the water replenishing liquid containing the nano activated carbon is characterized by mainly comprising the following components in parts by weight: 0.01-0.1 part of nano activated carbon, 3.2-5 parts of micromolecular hyaluronic acid, 0.3-2 parts of lecithin liposome, 100.6-1.2 parts of coenzyme Q, 4-16 parts of glycerol, 5-8 parts of propylene glycol, 0.2-1.5 parts of rose extract, 0.3-1.5 parts of allantoin, 0.3-0.8 part of amino acid humectant, 0.1-0.5 part of VE, 0.05-1 part of wheat germ extract, 0.05-0.1 part of linseed oil, 400.1-0.3 part of PEG and 30-80 parts of purified water.

Furthermore, the nano activated carbon is nano activated carbon, and the particle size of the nano activated carbon is 1-100 nm.

Furthermore, the nano activated carbon is modified with a hydroxyl functional group.

Furthermore, the modification method for modifying the hydroxyl functional group on the nano activated carbon comprises the following steps: mixing nano activated carbon with an ethanol solution with the mass concentration of 20-30% according to the weight ratio of 1 (50-1000), and carrying out ultrasonic treatment to obtain a uniformly dispersed nano activated carbon suspension; using 15% HNO₃The solution is oxidized, the constant temperature of 84-90 ℃ is kept for 20-35min, then the solution is placed in an ultrasonic processor for ultrasonic treatment, the power of the ultrasonic treatment is 1.05 KW-1.15 KW, the ultrasonic time is 5 min-18 min, and the temperature range is controlled to be 68-72 ℃; and finally, leaching and filtering the pH value to 7-7.5 by using deionized water, and then putting the filter material into a vacuum drying oven for drying treatment to obtain the nano activated carbon containing the hydroxyl functional group.

Further, the molecular weight range of the small molecule hyaluronic acid is 400000-800000.

A water replenishing liquid containing nano activated carbon is prepared by the following steps:

the method comprises the following steps: weighing nanometer activated carbon, micromolecular hyaluronic acid, lecithin liposome, coenzyme Q10, glycerol, propylene glycol, rose extract, allantoin, amino acid humectant, VE, wheat germ extract, linseed oil, PEG-40 and purified water according to the proportion for later use;

step two: dissolving the nano activated carbon by using deionized water to form a suspension, wherein the mass concentration of the nano activated carbon in the suspension is less than or equal to 10 per thousand;

step three: adding purified water into the small-molecule hyaluronic acid according to the weight ratio of 1:2, and stirring to obtain a small-molecule hyaluronic acid solution for later use;

step four: mixing the carbomer and the purified water according to the weight ratio of 1:3 for swelling to obtain a swollen carbomer solution for later use;

step five: mixing the lecithin liposome, coenzyme Q10, glycerol, propylene glycol, allantoin, amino acid humectant, VE, wheat germ extract, linseed oil and PEG-40, and stirring to obtain a mixture for later use;

step six: adding the mixture obtained in the fifth step into the swelled carbomer solution obtained in the third step, adding the hyaluronic acid solution obtained in the second step, standing for 30-60 minutes, and shaking by force until the hyaluronic acid stock solution is completely dissolved in the mixture; and continuously adding the suspension obtained in the step one, the rose extract and the residual purified water, placing the mixture in a homogenizer, starting the homogenizer, controlling the temperature to be 50-62 ℃, stirring at 12000-20000r/min, emulsifying and homogenizing the mixture for 20-30min, ultrasonically dispersing the mixture for 2-15min by using an ultrasonic cleaner while the mixture is hot, controlling the temperature during ultrasonic dispersion to be 55-70 ℃, then rapidly cooling the mixture under an ice bath condition, mechanically defoaming the mixture, and naturally cooling the mixture to 35 ℃ after defoaming is finished to obtain the water supplementing liquid.

The invention has the beneficial effects that: the moisturizing liquid is suitable for all types of skin, is particularly suitable for skin repair, moisturizing and moisturizing after micro-needles, phototherapy and various instrument treatments, and makes nutrient substances more easily enter the skin by utilizing a high-end liposome technology, so that the effects of quick repair, moisturizing and long-acting moisturizing are achieved, and roughness, fine wrinkles and dryness are improved.

Detailed Description

The technical solution of the present invention is further defined below with reference to the specific embodiments, but the scope of the claims is not limited to the description.

Example 1:

the moisturizing liquid containing the nano activated carbon mainly comprises the following components in parts by weight: 0.01 part of nano activated carbon, 3.2 parts of micromolecular hyaluronic acid, 0.3 part of lecithin liposome, 100.6 parts of coenzyme Q, 4 parts of glycerol, 5 parts of propylene glycol, 0.2 part of rose extract, 0.3 part of allantoin, 0.3 part of amino acid humectant, 0.1 part of VE, 0.05 part of wheat germ extract, 0.05 part of linseed oil, 400.1 parts of PEG-400 and 30 parts of purified water.

Wherein the nano activated carbon is nano activated carbon with the particle size of 1 nm. The nanometer activated carbon is modified with a hydroxyl functional group by the following method: mixing nano activated carbon with an ethanol solution with the mass concentration of 20% according to the weight ratio of 1:50, and carrying out ultrasonic treatment to obtain a uniformly dispersed nano activated carbon suspension; using 15% HNO₃The solution is oxidized, the constant temperature of 84 ℃ is kept for 20min, and then the solution is placed in an ultrasonic processor for ultrasonic treatment, wherein the power of the ultrasonic treatment is 1.05KW, the ultrasonic time is 5min, and the temperature range is controlled to be 68 ℃; and finally, leaching and filtering the pH value to 7 by using deionized water, and then putting the solution into a vacuum drying oven for drying treatment to obtain the nano activated carbon containing the hydroxyl functional group. The molecular weight range of the small molecule hyaluronic acid is 400000.

The preparation method of the moisturizing liquid containing the nano activated carbon comprises the following steps:

step two: dissolving the nano activated carbon by using deionized water to form a suspension, wherein the mass concentration of the nano activated carbon in the suspension is 2 per thousand;

step six: adding the mixture obtained in the fifth step into the swelled carbomer solution obtained in the third step, adding the hyaluronic acid solution obtained in the second step, standing for 30 minutes, and shaking by force until the hyaluronic acid stock solution is completely dissolved in the mixture; and (2) continuing adding the suspension obtained in the step one, the rose extract and the residual purified water, placing the mixture into a homogenizer, starting the homogenizer, controlling the temperature to be 50 ℃, stirring at 12000r/min, emulsifying and homogenizing the mixture for 20min, ultrasonically dispersing the mixture for 2min by an ultrasonic cleaner while the mixture is hot, controlling the temperature during ultrasonic dispersion to be 55 ℃, then quickly cooling the mixture under the ice bath condition, mechanically defoaming the mixture, and naturally cooling the mixture to 35 ℃ after defoaming is finished to obtain the water replenishing liquid.

Example 2:

the moisturizing liquid containing the nano activated carbon mainly comprises the following components in parts by weight: 0.055 part of nano activated carbon, 4.1 parts of micromolecular hyaluronic acid, 1.15 parts of lecithin liposome, 100.9 parts of coenzyme Q, 10 parts of glycerol, 6.5 parts of propylene glycol, 0.85 part of rose extract, 0.9 part of allantoin, 0.65 part of amino acid humectant, 0.3 part of VE, 0.525 part of wheat germ extract, 0.075 part of linseed oil, 400.2 parts of PEG-5 and 55 parts of purified water.

Wherein the nano activated carbon is nano activated carbon with the particle size of 50 nm. The nanometer activated carbon is modified with a hydroxyl functional group by the following method: mixing nano activated carbon with an ethanol solution with the mass concentration of 25% according to the weight ratio of 1:525, and carrying out ultrasonic treatment to obtain a uniformly dispersed nano activated carbon suspension; using 15% HNO₃The solution is oxidized, the constant temperature of 87 ℃ is kept for 27.min, and then the solution is placed in an ultrasonic processor for ultrasonic treatment, the power of the ultrasonic treatment is 1.1KW, the ultrasonic time is 11.5min, and the temperature range is controlled to be 70 ℃; and finally, leaching and filtering the pH value to 7 by using deionized water, and then putting the solution into a vacuum drying oven for drying treatment to obtain the nano activated carbon containing the hydroxyl functional group. The molecular weight range of the small molecule hyaluronic acid is 600000.

step two: dissolving the nano activated carbon by using deionized water to form a suspension, wherein the mass concentration of the nano activated carbon in the suspension is 6 per thousand;

step six: adding the mixture obtained in the fifth step into the swelled carbomer solution obtained in the third step, adding the hyaluronic acid solution obtained in the second step, standing for 45 minutes, and shaking by force until the hyaluronic acid stock solution is completely dissolved in the mixture; and (2) continuing adding the suspension obtained in the step one, the rose extract and the residual purified water, placing the mixture into a homogenizer, starting the homogenizer, controlling the temperature to be 56 ℃, stirring at 16000r/min, emulsifying and homogenizing for 25min, ultrasonically dispersing for 5.8min by an ultrasonic cleaner while the mixture is hot, controlling the temperature during ultrasonic dispersion to be 62.5 ℃, then rapidly cooling under an ice bath condition, mechanically defoaming, and naturally cooling to 35 ℃ after defoaming is finished to obtain the water replenishing liquid.

Example 3:

the moisturizing liquid containing the nano activated carbon mainly comprises the following components in parts by weight: 0.1 part of nano activated carbon, 5 parts of micromolecular hyaluronic acid, 2 parts of lecithin liposome, 101.2 parts of coenzyme Q, 16 parts of glycerol, 8 parts of propylene glycol, 1.5 parts of rose extract, 1.5 parts of allantoin, 0.8 part of amino acid humectant, 0.5 part of VE, 1 part of wheat germ extract, 0.1 part of linseed oil, PEG-400.3 parts and 80 parts of purified water.

Wherein the nano activated carbon is nano activated carbon with the particle size of 100 nm. The nanometer activated carbon is modified with a hydroxyl functional group by the following method: mixing nano activated carbon with an ethanol solution with the mass concentration of 30% according to the weight ratio of 1:1000, and carrying out ultrasonic treatment to obtain a uniformly dispersed nano activated carbon suspension; using 15% HNO₃The solution is oxidized, the solution is kept at the constant temperature of 90 ℃ for 35min, and then the solution is placed in an ultrasonic processor for ultrasonic treatment, wherein the power of the ultrasonic treatment is 1.15KW, the ultrasonic time is 18min, and the temperature range is controlled to be 72 ℃; and finally, leaching and filtering the solution with deionized water until the pH value is 7.5, and then putting the solution into a vacuum drying oven for drying treatment to obtain the nano activated carbon containing the hydroxyl functional group. The molecular weight range of the small molecule hyaluronic acid is 800000.

step two: dissolving the nano activated carbon by using deionized water to form a suspension, wherein the mass concentration of the nano activated carbon in the suspension is 10 per thousand;

step six: adding the mixture obtained in the fifth step into the swelled carbomer solution obtained in the third step, adding the hyaluronic acid solution obtained in the second step, standing for 60 minutes, and shaking by force until the hyaluronic acid stock solution is completely dissolved in the mixture; and (3) continuing adding the suspension obtained in the step one, the rose extract and the residual purified water, placing the mixture into a homogenizer, starting the homogenizer, controlling the temperature to be 62 ℃ and the stirring speed to be 20000r/min, emulsifying and homogenizing the mixture for 30min, ultrasonically dispersing the mixture for 15min by using an ultrasonic cleaner while the mixture is hot, controlling the temperature during ultrasonic dispersion to be 70 ℃, then quickly cooling and reducing the temperature under the ice bath condition, mechanically defoaming the mixture, and naturally cooling to 35 ℃ after defoaming is finished to obtain the water replenishing liquid.

Test of Water supplement liquid

1. Test specimen

(1) Experimental samples: the water-replenishing liquids prepared in the above examples 1, 2 and 3;

(2) reference sample: commercially available Aishi may be a repair peptide (manufactured by Shanghai Jiabo Biotech Co., Ltd.).

2. Test object

60 healthy, non-dermatological women between the ages of 33 and 56 were randomized into four groups of 15 individuals designated group A, group B, group C and group D.

3. Test method

(1) Determining test areas on the left and right front arms of the four groups of test objects, wherein the area of each test area is 6cm multiplied by 6 cm;

(2) the skin hydration of the four test areas of the test subjects was measured using a SKICON model 200 skin stratum corneum Water content meter and the skin elasticity of the four test areas of the test subjects was measured using a SEM model 575 skin elasticity tester, the results of which are referred to as initial values.

(3) The test subjects in group A used the moisturizing liquid prepared in example 1, the test subjects in group B used the moisturizing liquid prepared in example 2, the test subjects in group C used the moisturizing liquid prepared in example 3, and the test subjects in group D used the reference sample for seven consecutive days, each in the morning and evening, 0.5 g per day.

(4) After the test samples are continuously used for seven days by the test subjects in groups A, B, C and D, the skin hydration of the test areas of the test subjects in each group is tested by a SKICON 200 type skin horny layer water content tester, the skin elasticity of the test areas of the test subjects in each group is tested by an SEM575 type skin elasticity tester, and the test result is called a test value.

4. Test results

(1) Test results for group a: compared with the initial value, the average skin capacitance of the test subject is increased by 39%, the average skin elasticity of the test subject is increased by 18.2%, and the average skin firmness of the test subject is increased by 13.5%.

Test results for group B: compared with the initial value, the average capacitance of the skin of the test subject is increased by 38.3%, the average elasticity of the skin of the test subject is increased by 20.1%, and the average tightness of the skin of the test subject is increased by 16.2%.

Test results for group C: compared with the initial value, the average capacitance of the skin of the tested subject is increased by 40.5%, the average elasticity of the skin of the tested subject is increased by 23.7%, and the average tightness of the skin of the tested subject is increased by 17.4%.

(2) Test results for group D: compared with the initial value, the average capacitance of the skin of the tested person is increased by 17.3%, the average elasticity of the skin of the tested person is increased by 14.6%, and the average tightness of the skin of the tested person is increased by 10.1%.

The experimental results show that the water replenishing liquid has excellent water replenishing effect.

Claims

1. The water replenishing liquid containing the nano activated carbon is characterized by mainly comprising the following components in parts by weight: 0.01-0.1 part of nano activated carbon, 3.2-5 parts of micromolecular hyaluronic acid, 0.3-2 parts of lecithin liposome, 100.6-1.2 parts of coenzyme Q, 4-16 parts of glycerol, 5-8 parts of propylene glycol, 0.2-1.5 parts of rose extract, 0.3-1.5 parts of allantoin, 0.3-0.8 part of amino acid humectant, 0.1-0.5 part of VE, 0.05-1 part of wheat germ extract, 0.05-0.1 part of linseed oil, 400.1-0.3 part of PEG and 30-80 parts of purified water;

the nano activated carbon is modified with a hydroxyl functional group;

the modification method for modifying the hydroxyl functional group on the nano activated carbon comprises the following steps: mixing nano activated carbon with an ethanol solution with the mass concentration of 20-30% according to the weight ratio of 1 (50-1000), and carrying out ultrasonic treatment to obtain a uniformly dispersed nano activated carbon suspension; using 15% HNO₃The solution is oxidized, is kept at the constant temperature of 84-90 ℃ for 20-35min, and is put into an ultrasonic processor for ultrasonic treatment; finally, leaching and filtering the pH value to 7-7.5 by using deionized water, and then putting the filter material into a vacuum drying oven for drying treatment to obtain the nano activated carbon containing hydroxyl functional groups;

the preparation method comprises the following steps:

step six: adding the mixture obtained in the fifth step into the swelled carbomer solution obtained in the third step, adding the hyaluronic acid solution obtained in the second step, standing for 30-60 minutes, and shaking by force until the hyaluronic acid stock solution is completely dissolved in the mixture; and (2) continuing adding the suspension obtained in the step one, the rose extract and the residual purified water, placing the mixture in a homogenizer, starting the homogenizer, controlling the temperature to be 50-62 ℃, stirring at 12000-20000r/min, emulsifying and homogenizing for 20-30min, ultrasonically dispersing the mixture by using an ultrasonic cleaner while the mixture is hot, then rapidly cooling the mixture under the ice bath condition, mechanically defoaming the mixture, and naturally cooling the mixture to 35 ℃ after defoaming is finished to obtain the water supplementing liquid.

2. The water-replenishing liquid containing nano-activated carbon according to claim 1, wherein the nano-activated carbon is nano-sized activated carbon having a particle size of 1 to 100 nm.

3. The water replenishing liquid containing nano activated carbon according to claim 1, wherein the molecular weight of the small molecule hyaluronic acid is in the range of 400000-800000.