WO2002069913A1

WO2002069913A1 - Skin-improving composition set

Info

Publication number: WO2002069913A1
Application number: PCT/JP2001/001595
Authority: WO
Inventors: Sakae Shinkai
Original assignee: Clinical Cosmetic Co., Ltd.
Priority date: 2001-03-01
Filing date: 2001-03-01
Publication date: 2002-09-12
Also published as: JPWO2002069913A1

Abstract

A skin-improving composition set composed of three compositions including: an agent (A) containing, at least as the active ingredients, at least one amino acid, a hyaluronic acid salt, water-soluble collagen, dipotassium glycyrrhetinate, allantoin, hydrolyzed elastin solution and at least one plant extract; an agent (B) containing, at least as the active ingredients, at least one α-hydroxy acid, allantoin and dipotassium glycyrrhetinate; and an agent (C) containing, at least as the active ingredients, ceramide and at least one plant extract.

Description

Description Skin improvement composition set Technical field

The present invention relates to a composition set for improving skin. Background art

The outermost epidermis of human skin is reborn in about 28 days by metabolism. In other words, the newly born skin cells, which become the epidermis, gradually rise to the surface of the skin while changing the shape in the form of a scrum, and then come off as dirt about 28 days later. I have. Therefore, as long as this metabolism is performed normally, the skin will always remain fresh.

By the way, Shin Chen Window is a force that keeps itself healthy by changing its rhythm and tempo and disturbing the scrum of cells as it gets older, that is, homeostasis (homeostasis). Will break. The collapse of the homeostasis causes dullness and spots on the skin, and the skin becomes dry and rough.

Therefore, liquid preparations containing fruit acids (fruit acids) such as succinic acid, malic acid, citric acid, lactic acid, glycolic acid and tartaric acid, which are one kind of α-hydroxy acids (having carboxy and hydroxyl groups), as active ingredients Various skin-improving compositions have been proposed in (1) to improve the collapse of homeostasis by applying an ointment, to normalize the metabolic function of the skin, and to eliminate dryness and rough skin. — Japanese Patent Application Laid-Open No. 31053/1995, Japanese Patent Application Laid-Open No. 5-1399747)

• In other words, a-hydroxy acid has the effect of exfoliating the stratum corneum, promoting cell regeneration, and whitening.

By the way, when applying a skin-improving composition containing an α-hydroxy acid as an active ingredient as described above to the skin, it is first necessary to remove dirt on the skin surface using a stone test or a cleansing agent. However, with conventional stone cleansing agents, Because it contains surfactants, it completely rinses away the sebum that protects the skin. Therefore, if the concentration of hydroxy acids is increased in order to improve the effect of improving the skin, discomfort such as tingling may occur, and the effects of hydroxy acids may not be fully exerted, and the skin may be damaged instead. There is fear.

In view of the circumstances described above, the present invention can be used without discomfort even when the content of α-hydroxy acid is increased, and furthermore, the metabolic function is assisted without damaging the skin, and the skin is kept beautiful and fresh. The purpose of the present invention is to provide a composition set for improving skin that can be used. Disclosure of the invention

In order to achieve such an object, the composition set for skin improvement according to the present invention comprises at least one kind of amino acid, hyaluronate, water-soluble collagen, dipotassium glycyrrhizinate, allantoin, Elastin and at least

An agent comprising at least one plant extract as its active ingredient, an agent comprising at least one α-hydroxy acid, allantoin and dipotassium glycyrrhizinate as an active ingredient, a ceramide and However, the composition was composed of three compositions of the agent C containing at least one plant extract as at least its active ingredient.

The amino acid in the preparation is not particularly limited, but as described in Claim 2, at least one selected from the group consisting of glycine, alanine, proline, serine, threonine, arginine, lysine, and glutamic acid. It is preferable to use

The plant extract in Agent A is not particularly limited. Roman force beetle extract, anore force two force extract, /, ° rieta extract, kyucampa extract, seiyukizuta extract, zeyuaoi extract, seiyouwatokokisu, matsuri force extract, dokudami extract, licorice extract, malonier extract, kozozo extract, salvia It is preferable to use at least one selected from the group consisting of an extract, a three-color violet extract, and a horsetail extract. The monohydroxy acid contained in the agent B is not particularly limited as contained in the agent C. For example, as described in Claim 4, succinic acid, malic acid, citric acid, lactic acid, glycolic acid, tartaric acid It is preferable to use at least one selected from the group consisting of

The plant extract in the agent B is not particularly limited. For example, as described in claim 5, soybean extract, licorice extract, mulberry extract, cinnamon extract, natto extract, saxifrage extract, 、 wow / reshi flow extract, It is preferable to use at least one selected from the group consisting of gonex and char extract.

In addition, the agent C preferably contains at least a licorice extract as a plant extract, as described in claim 6.

The agent A is not particularly limited, but is preferably a geil type. In addition, the concentration of amino acids in agent A is particularly high if it can penetrate pores, sweat, and the stratum corneum, and leave dirt, bacteria, cosmetics, and old keratin, etc., while leaving sebum, and lift it up. Although not limited, it is preferably about 2% by weight to 5% by weight, more preferably 3% by weight to 4% by weight / ₀ .

The B agent is usually a lotion type, but when it contains an oily active ingredient, suspended particles having a particle size of 300 μππι (preferably 100 ni) or less containing the oily active ingredient are contained. It may be a dispersed oil-in-water type emulsion.

In other words, there is no problem in the case of water-soluble components, but in the case of oil-based components, if the suspension particle size is large, it is difficult to penetrate the active ingredients into the skin by sewing through the gaps in the lamellar structure of the skin, May not be able to achieve the desired effect.

Further, the above-mentioned emulsion is not particularly limited. For example, it can be produced by using a known micro-emulsifier such as a high-pressure homogenizer.

The concentration of _α- hydroxy acid in Agent B is not particularly limited, but is preferably about 4% by weight to 10% by weight, more preferably 7% by weight to 8% by weight, based on the total amount of Agent B. That is, if the concentration of the α-hydroxy acid is too low, the effect of adding the α-hydroxy acid is insufficient, and if the concentration is too high, the skin may be damaged.

Further, ρ} of the agent is not particularly limited, but is preferably about 4 to 6. That is, the lower the value of 11 is, the higher the effect of 0; If it is too low, it may be too irritating or cause skin damage. BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, embodiments of the skin improving composition set of the present invention will be described in detail. The composition for skin improvement according to the present invention is composed of three types of compositions, A-agent, B-agent, and C-agent.

Agent A contains at least one amino acid, hyaluronate, water-soluble collagen, dipotassium glycyrrhizinate, allantoin, elastin, and at least one plant extract as at least active ingredients, The remainder is gelled mainly by purified water and a known thickener, and by adding a preservative and the like as necessary.

B agents, alpha-hydroxy acids as malic acid, seed stone acid, lactic acid, in a total green cholate, comprising 7-8 wt ^_0/0 of the total, and further allantoin, at least as active ingredients and dipotassium glycyrrhizinate Included, the remainder is mainly purified water, and is a lotion type with ρ Η 4 to 6 to which solvents such as alcohol and ρ Η regulator are added as necessary.

Agent C is composed of ceramide, a small amount of α-hydroxy acid (malic acid, seed acid, lactic acid, and glycolic acid), sodium hyaluronate, water-soluble collagen, and complex plants (including at least licorice extract and shea extract) And as an active ingredient.

The composition set for improving skin is used as follows.

(1) Apply the agent to the skin of the face, neck, ears, back of hands, etc., massage the skin lightly from above as needed, and then wash away agent A.

(2) Take Agent B on the palm of your hand and apply lightly to the skin.

(3) If the B agent is used, apply the C agent on it.

The above-mentioned composition set for skin improvement is configured as described above, and has the following effects.

First, it was washed with A agent which contains amino acid as an active ingredient. The amino acid reacts with the water-soluble polymer by simply applying the agent to the skin, penetrates into pores, sweat, and the stratum corneum, and removes dirt such as dust, bacteria, cosmetics, and old dead skin while leaving sebum. Wrap it up and let it rise. In other words, it is possible to clean the skin and help the permeation of the active ingredient in Agent B without rubbing the skin or damaging the skin by massaging. Moreover, since the skin can be cleansed with sebum remaining, even if a B agent containing a high concentration of ct-hydroxy acid is applied to the skin, the skin feels less tingling and has excellent usability. There is no damage to them.

Agent A contains, in addition to amino acids, sodium hyaluronate, water-soluble collagen, strength D hydrolyzed elastin, dipotassium glycyrrhizinate, allantoin, and plant extract, so that it does not damage the skin and moisturizes it. can do. That is, sodium hyaluronate is a component that fills the space between the binding fibers and the cells of the skin, and has a strong water retention capacity to take the binding water between the cells and maintain the elasticity of the skin. It also has excellent moisturizing properties and keeps the skin smooth and soft.

Water-soluble collagen is a type of connective tissue protein present in the dermis of the skin. It forms a film on the skin and gives the skin moisture and flexibility with a high moisture effect. Hydrolyzed elastin (α-elastin) is a protein of connective tissue that exists in the dermis together with collagen, and is obtained by enzymatically decomposing elastin that is involved in the prevention of skin and tarmi. Improve elasticity and flexibility. Dipotassium glycyrrhizinate is a component in extracts extracted from Chinese licorice and has anti-inflammatory and anti-allergic effects, and is effective against eczema and dermatitis.

Allantoin is a uric acid derivative contained in fin-filled grass, which has an astringent effect on the skin, removes dead wounds, cracks, eczema, etc., cleanses, promotes new tissue formation .

The plant extract has moisturizing, blood circulation promotion, anti-inflammation, capillary enhancement, anti-inflammatory effect and so on.

(4) Since the agent contains a high concentration of _α- hydroxy acid, which is composed of malic acid, tartaric acid, lactic acid, and dalycholic acid, it can effectively activate cells of damaged skin. Specifically, malic acid improves stains made with active oxygen. Tartaric acid keeps the skin in favor, reduces bacterial growth and makes the skin more resistant. Lactic acid works on skin keratin, softens skin, increases moisture retention, and protects skin from drying out. Glycolic acid proliferates fibroblasts in the dermis layer of the skin and improves the firmness of the skin.

In addition, the application of the agent C, which contains a large amount of vitamins and minerals and promotes metabolism as an active ingredient, is applied over the agent B, so that the metabolism is further promoted. In addition, the licorice extract contained in the agent C is effective in detoxification and antiallergic effects, and can be used to improve atopic dermatitis.In addition, the extract contained a large amount of vitamin C and amino acids. Exhibits astringent, antioxidant, and ultraviolet absorption properties. Example

Hereinafter, more specific examples of the present invention will be described in detail.

(Example 1)

Jiel A, Lotion B, Lotion containing the following active ingredients

A skin-improving thread set composed of agent C was prepared.

(Active ingredient of agent A)

'Amino acid' · Approx. 3.2% by weight

(Breakdown L one Puroburin 0.002 wt%, L one-arginine 3.15 wt%, glycine 0.0001 wt ^_0/0, L Aranin 0.00004 wt ^_0/0, L-serine 0.

0001 5 weight ^_0/0, L-threonine 0.00002 wt%, L-lysine 0.00 007 weight ^_0/0, L - glutamic 0.000075 wt ^_0/0)

'Sodium hyaluronate - - - 0.01 weight ^_0/0

• Water-soluble collagen 0.01% by weight

'Dipotassium glycyrrhizinate0.0

'Allantoin' - - 0.01 weight ^_0/0

'Hydrolyzed elastin solution' · · 0.01% by weight

'Plant extract' · · · 0.04% by weight (Breakdown: Ougon'ekisu 0.01% by weight, assembly extract 0.01% by weight, Ryo Roeberaekisu 0.01% by weight, Al force two extract 0.001667 weight ^_0/0, Paris Etaekisu 0.001667 weight ^_0/0, queue birch extract 0.001667 weight ^_0/0, Si Yu ivy extract 0.001667 wt ^_0/0, Zeniaoiekisu 0.00166 7 wt ^_0/0, Si iodide two Wa Toco extract 0.001667 wt%)

(Active ingredient of agent B)

• α- human Dorokishi acid '- - 7.11 weight ^_0/0

(Breakdown: DL-malic acid 0.1% by weight, tartaric acid 0.01% by weight, glycolic acid

(3.5% by weight, lactic acid 3.5% by weight)

- allantoin - - - (). 01 weight ^_0/0

• dipotassium glycyrrhizin acid '- - 0.1 weight ^_0/0

(Active ingredient of agent c)

'Ceramide.. · Ο. 01 weight ^_0/0

• plant extracts. ... {). 08 weight ^_0/0

(Breakdown: licorice extract 0, 01 weight ^_0/0, Chiyaekisu 0.01% by weight, Daizueki scan 0.01% by weight, saxifrage extract 0.01% by weight, Uwaurushi flow extract 0.

01 weight ⁰ /. , Oregon extract 0.01% by weight, Ogon extract 0.011% by weight, Soybean extract 0.011 weight ⁰ / o)

• a- human Dorokishi acid - - - 0 - 04 weight ^_0/0

(Breakdown: DL-malic acid 0.01% by weight, tartaric acid 0.01% by weight, glycolic acid 0.01% by weight, lactic acid 0.011% by weight /.)

• hyaluronan opening sodium phosphate '- - 0.05 weight ^_0/0

Then, apply agent A to the face, wash the face with lukewarm water within 30 seconds, take agent B on the palm of your hand, apply lightly on the skin, and apply agent C after agent B is used. The procedure of application is 3 people in their 20s (A to C), 5 people in their 30s (A to E), 9 people in their 40s (A to I), 5 people in their 50s (A to E), 5 in the 60s (A

~ D) for each of the 26 female monitors to conduct the test twice a morning and evening, and the skin condition before, 1 month, 6 months, and 12 months before each monitor Was evaluated by a replica method using a myricin resin. In the above-mentioned replica method, after taking a replica of the skin, the surface of the replica was observed with a microscope of 17 times magnification, and classified into 1 to 5 as shown in Table 1 below.

The results are shown in Table 2 below.

【table 1】

[Table 2]

According to Table 2 above, if the composition for improving skin of the present invention comprising the three liquid preparations of A preparation, B preparation and C preparation is used, regardless of age, considerable skin improvement can be achieved in one month of use, regardless of age. The effect is seen, and it is clear that most people will have beautiful skin after 12 months.

It should be noted that the present invention is not limited to the above-described embodiments and examples, and that a vitamin supplement component, a fragrance, a solubilizer, a thickener, a humectant, a humectant, a solvent, and the like are contained in each composition. Ingredients to be added to ordinary cosmetics can be appropriately added to such an extent that the function of the active ingredient is not hindered. Of course, it goes without saying that it is diluted with purified water. Industrial applicability

Since the composition set for skin improvement according to the present invention is constituted as described above, it can be used without discomfort even if the concentration of o: -hydroxy acid is increased, and has a metabolic function without damaging the skin. Helps and keeps the skin beautiful and fresh. In addition, since the content of the a-hydroxy acid can be increased, the improvement effect is enhanced and the improvement speed is also increased.

【table 1】

Fortune evaluation Remarks

1 Elimination of skin and skin and suppuration of a wide range of stratum corneum

2 Unclear skin and dull skin, turning of horny layer

3 Skin and skin are visible but flat Normal skin

4 Skin and skin are clear and relatively beautiful

5 Beautiful skin with clear and clean skin

[Table 2]

Initial score 1 month later 6 months later 1 2 months later 0s A2 4 5 5

0s B 3 3 4 5

0s C 4 5 5 5

0s A 1 2 4 4

0s B 1 3 4 4

0s C 2 4 5 5

0s D 3 4 5 5

0s E 3 5 5 5

0s A 1 3 4 5

0s B2 3 3 4 '0s C2 3 4 4

0s D 2 4 5 5

0s E 3 4 4 5

0s F 3 4 5 5

0s G3 4 5 5

0s H 3 5 5 5

0s I 4 5.5 .5 5

0s A 2 3 3 4

0s B2 3 4 5

0s C 2 3 5 5

0s D 3 4 5 5

0s E 3 5 5 5

0s A 1 2 3 5

0s B 1 3 3 5

0s C2 3 3 4

0s D 2 3 4 5

Claims

The scope of the claims

1. At least one amino acid, hyaluronic acid salt, water-soluble collagen, dipotassium glycyrrhizinate, allantoin, force [I hydrolyzed elastin solution, and at least one plant extract, Agent A containing as an active ingredient at least one α-hydroxy acid, allantoin, and dicarium glycyrrhizinate as an active ingredient

C agent comprising ceramide and at least one plant extract at least as active ingredients thereof,

A skin-improving composition set comprising the three yarns.

2. The skin-improving skin according to claim 1, wherein the amino acid in the preparation is at least one selected from the group consisting of glycine, alanine, proline, serine, threonine, arginine, lysine, and glutamic acid. Composition set.

3. The plant extract in Agent A is ozone extract, assemblage extract, aloe kiss, potato millet extract, otogirisou extract, linden extract, tokinsen power extract yagnoremasou extract, roma power beetle extract, a / recani power extract, / rie ^ Consisting of extract of extract, cucumber, extract of squid, extract of senna, extract of saccharomyces cinnamon, extract of matsuri force, dokudami extract, licorice extract, malonie extract, kozzo extract, sanorevia extract, tricolor violet extract, and horsetail extract power 3. The composition set for improving skin according to claim 1, which is at least one member selected from the group. 0

4. The method according to any one of claims 1 to 3, wherein the α-hydroxy acid is at least one selected from the group consisting of succinic acid, malic acid, citric acid, citric acid, glycolic acid, and tartaric acid. The composition set for skin improvement according to the above.

5. The plant extract in the B agent and the C agent is at least one selected from the group consisting of soybean extract, licorice extract, mulberry extract, cherries extract, endosperm extract, saxifrage extract, ゥ owa / resi flow extract, ゥ gonex extract, and cherries extract. The set for improving skin according to any one of claims 1 to 4, which is a seed.

6. The composition for skin remediation according to any one of claims 1 to 5, comprising at least a C agent power and at least a licorice extract and a ginger extract as plant extracts.