CN106187793A - 5‑氨基酮戊酸及其衍生物的盐化合物和应用 - Google Patents

5‑氨基酮戊酸及其衍生物的盐化合物和应用 Download PDF

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Publication number
CN106187793A
CN106187793A CN201610568868.0A CN201610568868A CN106187793A CN 106187793 A CN106187793 A CN 106187793A CN 201610568868 A CN201610568868 A CN 201610568868A CN 106187793 A CN106187793 A CN 106187793A
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salt compound
acid
salt
coch
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赵鸣
周丽明
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Priority to CN202010877014.7A priority Critical patent/CN112010772A/zh
Publication of CN106187793A publication Critical patent/CN106187793A/zh
Priority to PCT/US2017/014791 priority patent/WO2017132178A2/en
Priority to JP2018538746A priority patent/JP6832358B2/ja
Priority to EP17744788.5A priority patent/EP3408254B1/en
Priority to US16/071,485 priority patent/US10653653B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/16—Halogenated acetic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Toxicology (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201610568868.0A 2016-01-26 2016-07-20 5‑氨基酮戊酸及其衍生物的盐化合物和应用 Pending CN106187793A (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN202010877014.7A CN112010772A (zh) 2016-01-26 2016-07-20 5-氨基酮戊酸及其衍生物的盐化合物和应用
PCT/US2017/014791 WO2017132178A2 (en) 2016-01-26 2017-01-24 Salts of 5-aminolevulinic acid and derivatives
JP2018538746A JP6832358B2 (ja) 2016-01-26 2017-01-24 ５−アミノレブリン酸及び誘導体の塩
EP17744788.5A EP3408254B1 (en) 2016-01-26 2017-01-24 Salts of 5-aminolevulinic acid and derivatives
US16/071,485 US10653653B2 (en) 2016-01-26 2017-01-24 Salts of 5-aminolevulinic acid and derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662286977P 2016-01-26 2016-01-26
USUS62/286977 2016-01-26

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CN202010877014.7A Division CN112010772A (zh) 2016-01-26 2016-07-20 5-氨基酮戊酸及其衍生物的盐化合物和应用

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CN106187793A true CN106187793A (zh) 2016-12-07

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CN202010877014.7A Pending CN112010772A (zh) 2016-01-26 2016-07-20 5-氨基酮戊酸及其衍生物的盐化合物和应用

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US (1) US10653653B2 (https=)
EP (1) EP3408254B1 (https=)
JP (1) JP6832358B2 (https=)
CN (2) CN106187793A (https=)
TW (1) TWI736577B (https=)
WO (1) WO2017132178A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108937864A (zh) * 2018-06-05 2018-12-07 四川大学 口腔黏膜诱发荧光检测诊断仪
WO2023019838A1 (zh) * 2021-08-17 2023-02-23 湖南复瑞生物医药技术有限责任公司 一种5-氨基酮戊酸酯化物、用途和农药组合物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL285384B2 (en) 2019-02-13 2024-11-01 Alpheus Medical Inc Non-invasive sonodynamic therapy
WO2020229878A1 (es) * 2019-05-15 2020-11-19 Universidad De La Frontera Composición de uso tópico para terapia fotodinámica
MX2021014512A (es) 2019-05-29 2022-02-11 Sonalasense Inc Sonosensibilizacion.
WO2022032283A2 (en) 2020-08-07 2022-02-10 Alpheus Medical, Inc. Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
KR102265592B1 (ko) * 2020-10-29 2021-06-17 김진왕 5-아미노레불린산 수화염화물을 포함하는 조성물
CN114504551B (zh) * 2020-11-16 2024-01-02 北京厚燊维康科技有限责任公司 可用于光动力治疗或诊断的制剂
WO2022115695A1 (en) * 2020-11-30 2022-06-02 Sonalasense, Inc. Metabolic targeting of low grade tumors

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1023338C (zh) * 1990-04-01 1993-12-29 张廷余 海洋波浪能发电装置
CN1102338C (zh) * 1994-11-28 2003-03-05 株式会社宇宙总合研究所 提高植物耐盐性的方法
CN1938264A (zh) * 2004-03-26 2007-03-28 弗托库尔公司 5－氨基乙酰丙酸或其衍生物的酸加成盐
US20070225518A1 (en) * 2006-03-22 2007-09-27 Zvi Malik 5-Aminolevulinic acid salts and their use
CN101061134A (zh) * 2004-11-02 2007-10-24 彭特法姆股份公司 新型可局部施用的抗表情皱纹和与年龄相关的皱纹的活性物质
JP2011246362A (ja) * 2010-05-24 2011-12-08 Tokyo Institute Of Technology アラレマイシン誘導体
CN103108623A (zh) * 2010-07-15 2013-05-15 先进医疗投资私人有限责任公司 用于治疗浅表病变的组合物
CN103265444A (zh) * 2013-04-24 2013-08-28 浙江大学 一种5-氨基乙酰丙酸磷酸盐的结晶方法
CN104478991A (zh) * 2014-12-10 2015-04-01 深圳市维琪医药研发有限公司 一种新型多肽化合物及其制备方法和其医药应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE397731A (https=) 1932-07-21
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
ATE202076T1 (de) 1995-03-10 2001-06-15 Photocure Asa Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie
US6492420B2 (en) 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
CA2206203A1 (en) 1997-05-27 1998-11-27 University Of British Columbia Photoactivation of endogenous porphyrins for treatment of psoriasis
FR2769626B1 (fr) * 1997-10-15 1999-12-03 Elf Aquitaine Exploration Prod Stabilisation de l'acide thioacetique
DE10003620A1 (de) 2000-01-28 2001-08-02 Asat Ag Applied Science & Tech 5-Aminolävulinsäure-Formulierung in nichtwässrigen Lösungsmitteln
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
US6723750B2 (en) 2002-03-15 2004-04-20 Allergan, Inc. Photodynamic therapy for pre-melanomas
NZ537142A (en) 2002-06-10 2008-01-31 Wyeth Corp Novel formate salt of O-desmethyl-venlafaxine
US20040147501A1 (en) * 2002-07-08 2004-07-29 Dolmans Dennis E.J.G.J. Photodynamic therapy
JP2006514567A (ja) 2003-04-23 2006-05-11 キュー エル ティー インク． 発毛
US20050124638A1 (en) * 2003-12-08 2005-06-09 Swayze Eric E. Benzimidazoles and analogs thereof as antivirals
DE602005025614D1 (de) 2004-03-30 2011-02-10 Cosmo Oil Co Ltd 5-aminolevulinsäure-phosphatsalz, verfahren zu dessen herstellung und dessen verwendung
US20120330216A1 (en) * 2011-06-24 2012-12-27 Saad Ibrahim Almohizea Methods and apparatus for skin rejuvenation
RU2482856C2 (ru) * 2011-08-05 2013-05-27 Общество С Ограниченной Ответственностью "Оксигон" Комплексное соединение 2-хлорпропионата цинка и 2-хлорпропионовой кислоты, фармацевтическая композиция для лечения заболеваний кожи, способ ее получения и способ лечения поражений кожи, ногтей и видимых слизистых
TWI551600B (zh) * 2011-09-30 2016-10-01 Ｃ＆Ｃ新藥研究所 新穎雜環衍生物及其用途
CN106110326A (zh) * 2011-10-12 2016-11-16 思佰益药业股份有限公司 移植器官的成活促进剂
CA2880422C (en) 2012-08-03 2021-02-09 Photocure Asa Derivatives of 5-aminolevulinic acid

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1023338C (zh) * 1990-04-01 1993-12-29 张廷余 海洋波浪能发电装置
CN1102338C (zh) * 1994-11-28 2003-03-05 株式会社宇宙总合研究所 提高植物耐盐性的方法
CN1938264A (zh) * 2004-03-26 2007-03-28 弗托库尔公司 5－氨基乙酰丙酸或其衍生物的酸加成盐
CN101061134A (zh) * 2004-11-02 2007-10-24 彭特法姆股份公司 新型可局部施用的抗表情皱纹和与年龄相关的皱纹的活性物质
US20070225518A1 (en) * 2006-03-22 2007-09-27 Zvi Malik 5-Aminolevulinic acid salts and their use
JP2011246362A (ja) * 2010-05-24 2011-12-08 Tokyo Institute Of Technology アラレマイシン誘導体
CN103108623A (zh) * 2010-07-15 2013-05-15 先进医疗投资私人有限责任公司 用于治疗浅表病变的组合物
CN103265444A (zh) * 2013-04-24 2013-08-28 浙江大学 一种5-氨基乙酰丙酸磷酸盐的结晶方法
CN104478991A (zh) * 2014-12-10 2015-04-01 深圳市维琪医药研发有限公司 一种新型多肽化合物及其制备方法和其医药应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NORITAKA IWAI等: "Synthesis and antibacterial activity of alaremycin derivatives for the porphobilinogen synthase", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *
RAMAKRISHNAN VALLINAYAGAM等: "Glycoside Esters of 5-Aminolevulinic Acid for Photodynamic Therapy of Cancer", 《BIOCONJUGATE CHEM.》 *
VALLINAYAGAM, RAMAKRISHNAN: "Synthesis of Novel Prodrugs for Targeted Photodynamic Therapy", 《DISSERTATION》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108937864A (zh) * 2018-06-05 2018-12-07 四川大学 口腔黏膜诱发荧光检测诊断仪
WO2023019838A1 (zh) * 2021-08-17 2023-02-23 湖南复瑞生物医药技术有限责任公司 一种5-氨基酮戊酸酯化物、用途和农药组合物

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TW201731811A (zh) 2017-09-16
WO2017132178A3 (en) 2017-12-07
TWI736577B (zh) 2021-08-21
JP6832358B2 (ja) 2021-02-24
WO2017132178A2 (en) 2017-08-03
EP3408254A2 (en) 2018-12-05
EP3408254B1 (en) 2020-11-04
JP2019517990A (ja) 2019-06-27
US10653653B2 (en) 2020-05-19
EP3408254A4 (en) 2019-01-30
US20190022044A1 (en) 2019-01-24
CN112010772A (zh) 2020-12-01

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Application publication date: 20161207