CN106176855A - A kind of concocting method of Radix Ginseng Rubra decoction pieces - Google Patents

A kind of concocting method of Radix Ginseng Rubra decoction pieces Download PDF

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CN106176855A
CN106176855A CN201610528689.4A CN201610528689A CN106176855A CN 106176855 A CN106176855 A CN 106176855A CN 201610528689 A CN201610528689 A CN 201610528689A CN 106176855 A CN106176855 A CN 106176855A
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decoction pieces
radix ginseng
ginseng rubra
dried
steaming
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CN106176855B (en
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刘雳
李静慧
胡建伟
李振丰
袁晓波
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ZHENGDA QINGCHUNBAO PHARMACEUTICAL CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses the concocting method of a kind of Radix Ginseng Rubra decoction pieces, it is characterised in that described method is: scarlet ginseng is cleaned, drained, then section or cutting；Steaming 30 90min again under 105 130 DEG C of saturated steam conditions, after steaming end, quick pressure releasing is to normal pressure, and evacuation is dried immediately, it is thus achieved that Radix Ginseng Rubra decoction pieces；The present invention can significantly reduce the microbial load of Radix Ginseng Rubra decoction pieces with saturated steaming, and even obtains aseptic level decoction pieces, improves the medical support level of medical material；Steaming, be dried, packaging integrated complete, material need not repeatedly be transported, and decreases unnecessary carrying waste, also reduces secondary pollution risk；Steaming and be greatly shortened with drying time, relatively traditional method time-consumingly reduces more than 50%；With ginsenoside Rg3The more traditional concocting method of rare saponin content for representing is high 3～5 times.

Description

A kind of concocting method of Radix Ginseng Rubra decoction pieces
(1) technical field
The present invention relates to a kind of Chinese crude drug Preparation process method, particularly to one by Radix Ginseng Rubra (fresh) Chinese crude drug Processing methods The method becoming Radix Ginseng Rubra decoction pieces.
(2) background technology
Radix Ginseng Rubra be Araliaceae Radix Ginseng Panaxgingseng C.A.Mey. cultivation product through concoct after dry root and Rhizome, has that strongly invigorating primordial QI, multiple arteries and veins be admittedly de-, effect of nourishing qi to stop.By tradition processing procedure, fresh ginseng steams number through steam Hour, then i.e. obtain Radix Ginseng Rubra through hot air drying.For guaranteeing patient medication safety, Radix Ginseng Rubra is as medical decoction pieces and with crude drug fecula When form is used as medicine, it is both needed to control microbial load." drug GMP certification inspection evaluation criteria " the 7023rd article of regulation: " be directly used as medicine Medicinal powder, microbial check should be done before dispensing ", Chinese drugs powder meets microbial limit requesting party and can be used as medicine." middle traditional Chinese medicines Allusion quotation " regulation of the 2015 years versions oral preparation of Chinese traditional medicinal microbial limit containing the former powder of medical material is that aerobe sum is not higher than 104cfu/ G, yeast and mold sum is not higher than 102Cfu/g, must not detect control bacterium simultaneously.In view of the potential microorganism of production process The risk polluted, the microbial load of raw material of Chinese medicine medicinal powder should at least reduce an order of magnitude.But, current Radix Ginseng Rubra medical material Being dried, pack, storing and in transportation, material is through repeatedly shifting, and transport machining tool and operating environment are difficult to effectively Control, add Radix Ginseng Rubra medical material rich in nutrition, microbiological pollution is serious.It is medical decoction pieces and be processed as medical material fecula in cutting Before, generally require and carry out two-stage sterilization process, the most time-consuming power consumption, and active ingredient loss can be caused.
Additionally, Radix Ginseng Rubra chemical composition there occurs notable change after concocting, the particularly important is that to create some peculiar Composition, such as ginsenoside Rg3、Rh2, maltol etc..Scientific research proves ginsenoside Rg3There is the biological activity of uniqueness, have anti- Tumor increases and metastasis effect, and has good action in terms of cardiovascular and nervous system protection it is considered to be the weight of Radix Ginseng Rubra Want active ingredient.But, the Radix Ginseng Rubra concocted in the conventional way, Rg3Content below 3/10000ths, be referred to as rare saponin. In Radix Ginseng Rubra processing procedure and method field, Zhao Fanglin etc. discloses a kind of increase Radix Ginseng by acid adding enhanced hydrolysis or Radix Panacis Quinquefolii Ginsenoside Rg3Method (CN101278954), leaf is the best etc. disclose a kind of with Radix Ginseng as raw material, add acetic acid and increase Ginsenoside Rg in Radix Ginseng Rubra3The method of content.But this kind of method external source in Radix Ginseng adds bronsted lowry acids and bases bronsted lowry, can cause Radix Ginseng Rubra quality Unknown impact.Jin Feng et al. discloses one and utilizes endogenous enzymes to promote ginsenoside's conversion, and obtains the side of high activity red ginseng Method (CN100423732C).Yu Shengjun etc. disclose one and utilize fermentable to promote Rg3The fermented red ginseng that content increases Preparation method (CN104784230A).Hong Xidao etc. disclose the Radix Ginseng Rubra manufacturer of a kind of high temperature high pressure process and drying under reduced pressure Method, is characterized in maintaining the intact form of circular ginseng, and increases total phenolic compounds, maltol and the content of rare saponin (CN103156896B), but technique is more complicated, and material need to repeatedly shift.But there is no a kind of Radix Ginseng Rubra concocting method at present can be effective Control microbial load, it is to avoid secondary pollution, the method that rare saponin content can be increased again.
(3) summary of the invention
It is an object of the present invention to provide one and can strictly control microbial load, be conducive to again increasing the people of rare saponin (red) ginseng process of preparation method.
The technical solution used in the present invention is:
The present invention provides the concocting method of a kind of Radix Ginseng Rubra decoction pieces, and described method is: scarlet ginseng (or other Radix Ginseng) washed Only, drain, then section or cutting；30-90min is steamed again under 105-130 DEG C of saturated steam conditions, quick after steaming end Pressure release is to normal pressure, and evacuation is dried immediately, it is thus achieved that Radix Ginseng decoction pieces.
Further, described scarlet ginseng clean after, airing, air-dry or cold drying to mass water content 50%～70%, In order to avoid content excessively runs off when cutting.First pre-dried Radix Ginseng Rubra is removed dis-medicinal part during Radix Ginseng Rubra cutting, then cut In flakes or section.According to actual needs, if as medical decoction pieces, can cutting be circular or subcircular sheet, thickness be 3-5mm；If making Can cutting be sheet or section for Chinese patent medicine raw materials for production, thickness be less than 20mm.Carry out after cutting concocting and being dried, beneficially steam Penetrate and evaporate with moisture, process time therefore can be greatly shortened.
Further, described section or the thickness of cutting or a length of 3-20mm.
Further, described evacuation is dried finger and is evacuated to-0.1～-0.08MPa, is dried 5-10h.
Further, the mass water content that described evacuation is dried to Radix Ginseng Rubra decoction pieces is not higher than 12%.
Further, the condition that steams described in is that 121 DEG C of saturated vapors steam 30min.
Further, the concocting method of described Radix Ginseng Rubra decoction pieces is: after scarlet ginseng being cleaned, be dried to aqueous under the conditions of 40 DEG C Amount 50%, then cuts into slices, and thickness is 3～5mm；30min is steamed again under 121 DEG C of saturated steam conditions, quick after steaming end Pressure release is to normal pressure, and is evacuated to-0.085MPa immediately, is dried to water content 6%～12%, it is thus achieved that Radix Ginseng Rubra decoction pieces.
The present invention steams, drying integrated completes, and period need not handling material.Saturated steaming temperature is 105-130 DEG C, steams Time processed is 30-90min, not only completes to steam processing, and can play sterilization effect.After steaming end, quick pressure releasing is extremely Normal pressure, evacuation is dried 5-10h immediately, and in equipment, relative vacuum is maintained at-0.1～-0.08MPa.Quick pressure releasing and take out true Sky, can utilize the gasification of water quickly to reduce temperature of charge, reduce active ingredient loss.According to material and equipment situation, Ke Yixuan Select radiation and conduction pattern provides energy.In order to improve ginsenoside Rg3's retention rate, temperature of charge can be controlled 40 DEG C with Under.
Additionally the described saturated vapor described in this case steams recommendation in high pressure steam sterilization exsiccator or high voltage pulse sterilizing Carry out in drying cupboard.
Being dried after terminating, material water ratio is not higher than 12%.Packaging should be completed under clean protective condition and seal, it is ensured that Decoction pieces is no longer influenced by secondary pollution.The Radix Ginseng Rubra decoction pieces prepared as stated above, aerobe sum is 103Below cfu/g, mycete and Yeast sum is at below 10cfu/g, it might even be possible to meet aseptic decoction pieces requirement.The total amount of ginsenoside Re and Rg1 is not less than 0.5%, ginsenoside Rb1's content is not less than 0.3%, and ginsenoside Rg3's content can be close to 0.1%.
The advantage of the present invention includes:
1. can significantly reduce the microbial load of Radix Ginseng Rubra decoction pieces with saturated steaming, even obtain aseptic level decoction pieces, improve The medical support level of medical material；
2. steaming, be dried, packaging integrated complete, material need not repeatedly be transported, and decreases unnecessary carrying waste, also Reduce secondary pollution risk；
3. steaming and be greatly shortened with drying time, relatively traditional method time-consumingly reduces more than 50%；
4. with ginsenoside Rg3The more traditional concocting method of rare saponin content for representing is high 3～5 times.
(4) detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described further, but protection scope of the present invention is not limited in This:
Embodiment 1:
Taking the commercially available 5 years each 1000g of fresh Radix Ginseng Rubra in Jilin Ji'an, (high pressure steams to be divided into A group (by tradition concocting method) and B group System vacuum drying).
A group Radix Ginseng Rubra drains to epidermis noresidue water after cleaning, and water proof steams 3h, is then transferred to convection oven, at 50 DEG C Under the conditions of dry 72h, soften rear shave, obtain decoction pieces A.
B group Radix Ginseng Rubra drains to epidermis noresidue water after cleaning, and proceeds to convection oven, predrying 2h, medicine under the conditions of 40 DEG C Material mass water content about 55%, then cuts into the similar round sheet of about 5mm, proceeds to YXQ-LS-50G high pressure steam sterilization exsiccator (external water ring vacuum pump), treats that temperature rises to 121 DEG C (saturated vapors), keeps 30min, is deflated to normal pressure the most immediately, then Evacuation, heating-up temperature is set as 35 DEG C, and relative vacuum degree maintains about-0.085MPa, dry 24h and i.e. obtains decoction pieces B.
Above-mentioned decoction pieces is airtight with sterilized sampling bag under clean protective condition, and deposits at 4 DEG C.
Measuring prepared slice quality moisture content with dry weight-loss method, A group is 10.2%, and B group is 10.8%.
Drink sheet A and each 10g of decoction pieces B, add sodium chloride-peptone buffer agent aseptic for pH7.0 to 100ml, shaking 20min.Then taking supernatant stepwise dilution and carry out plate cultivation, remaining operation is with reference to " Chinese Pharmacopoeia " 2010 editions annex inspections Survey total number of bacteria, mycete and yeast sum.
Ginsenoside Re, Rg and Rb in decoction pieces1Assay with reference under " Chinese Pharmacopoeia " 2010 editions one " Radix Ginseng " item Regulation detection.
Ginsenoside Rg3Assay using the following method:
Sample pretreatment: drink sheet and beat powder, accurately weighed 1g powder, puts in tool plug conical flask, accurate addition volumetric concentration 75% ethanol water 50ml, ultrasonic (300W) extracts 60min, sucking filtration, and residue washs with volumetric concentration 75% ethanol water, merges Filtrate and cleaning mixture, rotary evaporated to dryness, with initial flow phase (29% acetonitrile solution) constant volume 5ml, cross 0.45 μm filter membrane, i.e. ?.
Chromatographic condition: chromatograph Agilent 1260HPLC (400bar), chromatographic column Agilent Extend-C18 (250mm × 4.6mm, 5 μm), column temperature 30 DEG C, flow velocity: 1ml/min, flowing phase acetonitrile (A)-pure water (B), elution requirement is shown in Table 1.
Table 1 gradient table
The testing result of the different processing procedure decoction pieces of table 2
Decoction pieces testing result (being shown in Table 2) shows, uses Radix Ginseng Rubra decoction pieces prepared by present invention process, and microbial load is lower, Ginsenoside Re, Rg1And Rb1Content meets regulation；Ginsenoside Rg3Content be tradition 4.3 times of process of preparing Chinese medicine group.
Embodiment 2:
Taking the commercially available scarlet ginseng in Jilin, after cleaning, single-row stacking is less than 0.5m, and (relative air humidity is low for indoor forced ventilation In 30%) overnight, quality of medicinal material moisture content is down to about 70%, removes dis-medicinal part, then cut into the section of about 1-2cm, take 100kg monolayer is piled up and is proceeded to XGI.DMF-210B high voltage pulse sterilizing-drying cabinet (external water ring vacuum pump), is passed through saturated vapor Treating that gas phase temperature rises to 105 DEG C and starts timing, period temperature fluctuation range controls at 105～130 DEG C, keeps 60min, then stands I.e. be deflated to normal pressure, then evacuation, heating coil temperature be set in 40～50 DEG C, relative vacuum degree maintain-0.08～- 0.085MPa, dry 50h i.e. obtain Radix Ginseng Rubra decoction pieces.
Above-mentioned sample after testing, ginsenoside Re and Rg1Sum, Rb1、Rg3Content be respectively 0.43%, 0.32% He 0.078%.Total number of bacteria is less than 100cfu/g, mycete and yeast sum less than 10cfu/g.

Claims (8)

1. the concocting method of a Radix Ginseng Rubra decoction pieces, it is characterised in that described method is: scarlet ginseng is cleaned, is drained, then cuts into slices Or cutting；Steaming 30-90min under 105-130 DEG C of saturated steam conditions again, after steaming end, quick pressure releasing is to normal pressure, exists side by side I.e. evacuation is dried, it is thus achieved that Radix Ginseng Rubra decoction pieces.
2. the concocting method of as claimed in claim 1 Radix Ginseng Rubra decoction pieces, it is characterised in that after described scarlet ginseng is cleaned, airing, air-dries Or cold drying to mass water content 50%～70%.
3. the concocting method of Radix Ginseng Rubra decoction pieces as claimed in claim 1, it is characterised in that described section or the thickness of cutting or length For 3-20mm.
4. the concocting method of as claimed in claim 1 Radix Ginseng Rubra decoction pieces, it is characterised in that described evacuation be dried finger be evacuated to- 0.1～-0.08MPa, it is dried 5-10h.
5. the concocting method of Radix Ginseng Rubra decoction pieces as claimed in claim 4, it is characterised in that described evacuation is dried to Radix Ginseng Rubra decoction pieces Mass water content is not higher than 12%.
6. the concocting method of as claimed in claim 1 Radix Ginseng Rubra decoction pieces, it is characterised in that described in steam condition be 121 DEG C of saturated vapors Steam 30min.
7. the concocting method of Radix Ginseng Rubra decoction pieces as claimed in claim 1, it is characterised in that described method is: after scarlet ginseng being cleaned, Being dried under the conditions of 40 DEG C to mass water content 50%～70%, then cut into slices, thickness is 3～5mm；Again at 121 DEG C of saturated vapors Under the conditions of steam 30min, after steaming end, quick pressure releasing is to normal pressure, and is evacuated to-0.085MPa immediately, is dried to quality and contains The water yield 6%～12%, i.e. obtains Radix Ginseng Rubra decoction pieces.
8. the concocting method of as claimed in claim 1 Radix Ginseng Rubra decoction pieces, it is characterised in that described in steam and be dried at high pressure steam sterilization Carry out in device or high voltage pulse sterilizing-drying cabinet.
CN201610528689.4A 2016-06-30 2016-06-30 A kind of concocting method of red ginseng medicine materical crude slice Active CN106176855B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109793767A (en) * 2017-11-17 2019-05-24 牡丹江医学院 A kind of red ginseng manufacture craft promoting content of ginsenoside
CN114869925A (en) * 2022-04-29 2022-08-09 中国药科大学 Ginseng radix Rubri processing method for increasing content of rare saponins in Ginseng radix
CN116196344A (en) * 2023-03-13 2023-06-02 重庆市急救医疗中心(重庆市第四人民医院、重庆市急救医学研究所) Preparation method of red ginseng decoction pieces

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1613361A (en) * 2003-11-05 2005-05-11 薛文峰 Instant ginseng tablets
CN101537025A (en) * 2009-05-05 2009-09-23 中国科学院长春应用化学研究所 Preparation method for increasing content of total saponin, low polarity saponin and argininyl fructosy glucose in red ginseng
CN101829171A (en) * 2010-05-14 2010-09-15 长春工业大学 Automatic processing device and process method for steaming and drying ginseng

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1613361A (en) * 2003-11-05 2005-05-11 薛文峰 Instant ginseng tablets
CN101537025A (en) * 2009-05-05 2009-09-23 中国科学院长春应用化学研究所 Preparation method for increasing content of total saponin, low polarity saponin and argininyl fructosy glucose in red ginseng
CN101829171A (en) * 2010-05-14 2010-09-15 长春工业大学 Automatic processing device and process method for steaming and drying ginseng

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李向高: "提高人参加工炮制质量的探讨", 《中成药研究》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109793767A (en) * 2017-11-17 2019-05-24 牡丹江医学院 A kind of red ginseng manufacture craft promoting content of ginsenoside
CN109793767B (en) * 2017-11-17 2021-07-16 牡丹江医学院 Ginseng radix Rubri preparation process capable of increasing ginsenoside content
CN114869925A (en) * 2022-04-29 2022-08-09 中国药科大学 Ginseng radix Rubri processing method for increasing content of rare saponins in Ginseng radix
CN116196344A (en) * 2023-03-13 2023-06-02 重庆市急救医疗中心(重庆市第四人民医院、重庆市急救医学研究所) Preparation method of red ginseng decoction pieces
CN116196344B (en) * 2023-03-13 2024-02-13 重庆市急救医疗中心(重庆市第四人民医院、重庆市急救医学研究所) Preparation method of red ginseng decoction pieces

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