CN101785826A - Thunberg fritillary flower micropowder preparation method - Google Patents
Thunberg fritillary flower micropowder preparation method Download PDFInfo
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- CN101785826A CN101785826A CN201010122848A CN201010122848A CN101785826A CN 101785826 A CN101785826 A CN 101785826A CN 201010122848 A CN201010122848 A CN 201010122848A CN 201010122848 A CN201010122848 A CN 201010122848A CN 101785826 A CN101785826 A CN 101785826A
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- thunberg fritillary
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- fritillary flower
- bulbus fritillariae
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- 241000935235 Fritillaria meleagris Species 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000001694 spray drying Methods 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000000605 extraction Methods 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 abstract description 4
- 239000013543 active substance Substances 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 2
- 230000005484 gravity Effects 0.000 abstract 1
- IUKLSMSEHKDIIP-UHFFFAOYSA-N petine Natural products CC1(O)C2CCC3C4CC(O)C5CC(O)CCC5(C)C4CC3C2CN2C1CCC(C)C2 IUKLSMSEHKDIIP-UHFFFAOYSA-N 0.000 description 9
- 206010011224 Cough Diseases 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 206010062717 Increased upper airway secretion Diseases 0.000 description 6
- 208000026435 phlegm Diseases 0.000 description 6
- IUKLSMSEHKDIIP-BZMYINFQSA-N Verticine Chemical compound C([C@@H]1[C@@H](O)C[C@H]2[C@@H]3CC[C@@H]4[C@]5(C)O)[C@@H](O)CC[C@]1(C)[C@H]2C[C@H]3[C@@H]4CN1[C@H]5CC[C@H](C)C1 IUKLSMSEHKDIIP-BZMYINFQSA-N 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229930182478 glucoside Natural products 0.000 description 4
- -1 peimine glucoside Chemical class 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 230000003419 expectorant effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 241000605372 Fritillaria Species 0.000 description 2
- OVHUAFPHYGFWPY-UHFFFAOYSA-N Imperialin Natural products CC1CN2CC3C(CCC4C3CC5C4CC(=O)C6CC(O)CCC56C)CC2C(C)(O)C1 OVHUAFPHYGFWPY-UHFFFAOYSA-N 0.000 description 2
- IQDIERHFZVCNRZ-YUYPDVIUSA-N Imperialine Chemical compound C([C@@H]1C(=O)C[C@H]2[C@@H]3CC[C@@H]4[C@]5(C)O)[C@@H](O)CC[C@]1(C)[C@H]2C[C@H]3[C@@H]4CN1[C@H]5CC[C@H](C)C1 IQDIERHFZVCNRZ-YUYPDVIUSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
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- 206010006451 bronchitis Diseases 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 210000004211 gastric acid Anatomy 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 235000015170 shellfish Nutrition 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241001547125 Fritillaria thunbergii Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010018498 Goitre Diseases 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
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- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
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- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
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- 241000411851 herbal medicine Species 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
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- 210000002784 stomach Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a thunberg fritillary flower micropowder preparation method which includes the steps that: (1) fresh Thunberg fritillary flower is placed in an extraction tank, and water is added to the extraction tank according to the weight ratio of 1:5-30 of Thunberg fritillary flower and water; (2) the internal pressure of the extraction tank is controlled to be 1-1.5 atmospheric pressure, the extraction operation is performed for three times at the temperature of 50-140 DEG C and the extracts in three times are collected together to have vacuum concentration to realize the specific gravity of 1.05-1.2 at temperature of 40-90 DEG C; (3) the extract obtained in step (2) is pumped into the top of a spray drying tower to proceed spray drying at the inlet air temperature of 140-200 DEG C and the outlet air temperature of 60-90 DEG C of the spray drying tower so as to obtain the Thunberg fritillary flower micropowder. The thunberg fritillary flower micropowder preparation method not only maintains the active substances of the Thunberg fritillary flower, but also effectively removes the substances incapable of being absorbed by human body, and is convenient for transport.
Description
Technical field
The present invention relates to a kind of product of producing with Fritillary flower, relate to a kind of preparation method of thunberg fritillary flower micropowder particularly.
Background technology
Bulbus Fritillariae Uninbracteatae is the conventional Chinese medicine of a kind of preventing phlegm from forming and stopping coughing, clearing heat and moistening lung, has very long medicinal history, and the main source of its medical material is the Fritillaria Fritillaria among the Liliaceae Liliaceae, and this belongs to the whole world 130 kinds approximately.Typical Fritillaria plant Bulbus Fritillariae Thunbergii Fritillaria thunbergii Miq. is one of famous Chinese crude drug " Zhejiang eight flavors ", it is the treasure in the Bulbus Fritillariae Uninbracteatae family, be the key medicine simply of preventing phlegm from forming and stopping coughing in the prescriptions of Chinese medicine, clearing heat and moistening lung, be herbaceos perennial, the bulb hemispherical.Call Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Thunbergii, resemble shellfish, BULBUS FRITILLARIAE THUNBERGII, pearl shellfish, bulb is used as medicine, effects such as clearing heat and moistening lung, preventing phlegm from forming and stopping coughing and eliminating stagnation are arranged, cure mainly upper respiratory tract infection, laryngopharynx swelling and pain, bronchitis, lung abscess, cough due to lung-heat, abundant expectoration, stomach, duodenal ulcer, mastitis, thyromegaly, pain furuncle and phyma poison.The medical material Bulbus Fritillariae Uninbracteatae has long medication history, and " book on Chinese herbal medicine justice " carries: the Bulbus Fritillariae Thunbergii purging with bitter and cold drugs, and can eliminating stagnation." detailed outline is picked up any lost article from the road " carries: the sharp expectorant that detoxifies, open lung qi dispersing gas, and the man folder of all lungs wind-fire has expectorant, and the person should this.Wild in sylvan life or hillside thick grass, be distributed in provinces such as Zhejiang, Jiangsu, Hunan.In areas such as Ningbo of Zhejiang, Pan'ans a large amount of cultivations are arranged, also there is the demonstration cultivation in other areas.And after Bulbus Fritillariae Thunbergii can suppress effects such as pulmonary carcinoma, hepatocarcinoma and obtains certainly in recent years, Bulbus Fritillariae Thunbergii found oneself greatly elevated in fame and status especially, and price is with day soaring, and output and sales volume all sharply increase, and the development prospect of Bulbus Fritillariae Thunbergii is very optimistic.
Modern study shows, the main bioactive substance of Bulbus Fritillariae Thunbergii is its alkaloid and its glycosides, and these active component do not exist only in the bulb in the Bulbus Fritillariae Uninbracteatae, and in its stem He in spending distribution are arranged all, especially with the alkaloid in the alabastrum for the highest, reach 0.6%.But, traditional medicinal bulb of all using Bulbus Fritillariae Uninbracteatae, and seldom use its other nutrition organs.Chinese Pharmacopoeia one one of version in 1977 had announced once that Fritillary flower also had cough-relieving, and the expectorant effect can be used for cough with copious phlegm, bronchitic treatment.Clinical Application shows that it rarely has the untoward reaction report, and its toxicity is very low, can be used as a kind of food of medicine-food two-purpose.The flower of Bulbus Fritillariae Thunbergii product of having reported mainly contains flower of Bulbus Fritillariae Thunbergii sheet and flower of Bulbus Fritillariae Thunbergii fluid extract, all is to be used for cough-relieving, reduces phlegm cough with copious phlegm, diseases such as bronchitis.The flower of Bulbus Fritillariae Thunbergii sheet is that fine powder and starch that concentrated solution behind the decocting in water precipitate with ethanol and Fritillary flower are ground into are mixed, the tabletting sugar coating forms, but there is a lot of materials not to be absorbed by the body in the fine powder that Fritillary flower wherein is ground into, and in the decocting in water precipitate with ethanol, also have suitable a part of active substance to be precipitated in the lump to have discarded, thereby caused the loss of a large amount of active component.And flower of Bulbus Fritillariae Thunbergii stream soaks the ethanol water that becomes Fritillary flower decocting in water precipitate with ethanol, not only has the losing issue of active component equally, and the product of this ethanol water state also be not easy to the transportation, also be unfavorable for directly drinking.
Summary of the invention
The technical problem to be solved in the present invention is the above-mentioned deficiency at prior art, a kind of active substance that can keep flower of Bulbus Fritillariae Thunbergii is provided, can effectively remove the material that much is not absorbed by the body in the flower of Bulbus Fritillariae Thunbergii again, and the preparation method of the thunberg fritillary flower micropowder of being convenient to transport.
In order to solve the problems of the technologies described above, technical scheme of the present invention is: a kind of preparation method of thunberg fritillary flower micropowder, and preparation process comprises: (1) puts into extraction pot with fresh flower of Bulbus Fritillariae Thunbergii, is 1: 5～30 to add entry by the weight ratio of flower of Bulbus Fritillariae Thunbergii and water;
(2) pressure in the control extraction pot is at 1～1.5 atmospheric pressure, and merge extractive liquid, after extracting 1～3 time under 50～140 ℃ is 1.05～1.2 with the extracting solution that merges at 40～90 ℃ of following vacuum concentration to proportion then;
(3) concentrated solution with step (2) gained pumps into the spray drying tower top, is that 140～200 ℃ and leaving air temp are under 60～90 ℃ the condition in the spray drying tower inlet temperature, carries out spray drying, obtains thunberg fritillary flower micropowder of the present invention.
Above-mentioned spray drying can be centrifugal spray drying or pressure spray dryer.
Thunberg fritillary flower micropowder after the present invention is spray-dried can the original shape form as product, also it can be pressed into tablet, perhaps dress up capsule with the capsule subpackage machine.
Advantage of the present invention and beneficial effect:
1. the present invention has adopted low temperature (promptly being 140～180 ℃ in the spray drying tower inlet temperature is to think low temperature under 60～90 ℃ with leaving air temp) drying process with atomizing, not only go for big requirement of producing, and the time that material is heated is very short, has avoided the bioactive ingredients in the flower of Bulbus Fritillariae Thunbergii to be destroyed and runs off.
2. the thunberg fritillary flower micropowder of the present invention's preparation is a solid forms, not only be convenient to transportation and storage, and its water solublity is fine, contain the stronger peimine glucoside of water solublity through liquid chromatograph mass spectrography analytical tool analysis demonstration, the peimine glucoside not only helps absorption of human body more, and it can also be hydrolyzed to peimine under the gastric acid effect in human body, more helps drinking, and takes medicine conveniently.
Description of drawings
Fig. 1 is the liquid chromatograph of thunberg fritillary flower micropowder of the present invention---the mass spectral analysis spectrogram;
Among the figure: 1 is the peimine glucoside, and 2 is peiminine, and 3 is peimine, and 4 is different peimine.
The specific embodiment
Below by specific embodiment technical scheme of the present invention is described in further detail, but the present invention not only is confined to following examples.
The fresh 320kg flower of Bulbus Fritillariae Thunbergii of plucking is put into many kinetic energy extraction pot (DTQ-3.0, Wenzhou, Zhejiang) in, the water that adds 10 times of weight of flower of Bulbus Fritillariae Thunbergii, pressure is under 1.2 atmospheric pressure in the control extraction pot, extract back merging filtrate (extracting solution) down twice in 90 ℃, at 60 ℃ of following vacuum concentration to proportion is 1.08, concentrated solution is pumped into the centrifugal spray drying tower top, in the centrifugal spray drying tower inlet temperature is under the condition of 80 ℃ of 150 ℃, leaving air temp, spray drying to water content below 5%, thunberg fritillary flower micropowder 80kg of the present invention.Carry out amino acid analysis according to GB GB/T5009.124-2003, the results are shown in Table 1, show that the thunberg fritillary flower micropowder that processes contains rich in amino acid, comprises the aminoacid that human body is necessary.Liquid chromatograph---mass spectrometry is analyzed (see figure 1) and is shown that it contains peimine 3 identical with the Bulbus Fritillariae Thunbergii bulb and peiminine 2, but also contain the stronger peimine glucoside 1 of water solublity, it not only helps absorption of human body more, and it can also be hydrolyzed to peimine under the gastric acid effect in human body.
Experimental example 1 resulting Bulbus Fritillariae Thunbergii flower micropowder is pressed into tablet with tablet machine.
Experimental example 1 resulting Bulbus Fritillariae Thunbergii flower micropowder is dressed up capsule with the capsule subpackage machine.
Various amino acid contents in the thunberg fritillary flower micropowder sample of table 1 embodiment 1 gained
Claims (2)
1. the preparation method of a thunberg fritillary flower micropowder, it is characterized in that: preparation process comprises: (1) puts into extraction pot with fresh flower of Bulbus Fritillariae Thunbergii, is that 1: 5～30 ratio adds entry in the weight ratio of flower of Bulbus Fritillariae Thunbergii and water;
(2) pressure in the control extraction pot is at 1～1.5 atmospheric pressure, and merge extractive liquid, after extracting 1～3 time under 50～140 ℃ is 1.05～1.2 with the extracting solution that merges at 40～90 ℃ of following vacuum concentration to proportion then;
(3) concentrated solution with step (2) gained pumps into the spray drying tower top, is that 140～200 ℃ and leaving air temp are under 60～90 ℃ the condition in the inlet temperature of spray drying tower, carries out spray drying, obtains thunberg fritillary flower micropowder of the present invention.
2. the preparation method of a kind of thunberg fritillary flower micropowder according to claim 1, it is characterized in that: above-mentioned spray drying is centrifugal spray drying or pressure spray dryer.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010122848A CN101785826A (en) | 2010-04-30 | 2010-04-30 | Thunberg fritillary flower micropowder preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010122848A CN101785826A (en) | 2010-04-30 | 2010-04-30 | Thunberg fritillary flower micropowder preparation method |
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| CN101785826A true CN101785826A (en) | 2010-07-28 |
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|---|---|---|---|
| CN201010122848A Pending CN101785826A (en) | 2010-04-30 | 2010-04-30 | Thunberg fritillary flower micropowder preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857259A (en) * | 2014-11-20 | 2015-08-26 | 浙江康恩贝制药股份有限公司 | Fritillaria flower extractive, preparation method therefore and applications |
| CN107823135A (en) * | 2017-11-17 | 2018-03-23 | 湖北医药学院 | Peininine nano-emulsion and preparation method and application |
| CN115372501A (en) * | 2022-07-27 | 2022-11-22 | 广州科曼生物科技有限公司 | Thunberg fritillary bulb or Hubei fritillary bulb contrast extract and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322856C (en) * | 2005-05-13 | 2007-06-27 | 北京正大绿洲医药科技有限公司 | Fritillaria flower drip pill and its preparation method |
-
2010
- 2010-04-30 CN CN201010122848A patent/CN101785826A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322856C (en) * | 2005-05-13 | 2007-06-27 | 北京正大绿洲医药科技有限公司 | Fritillaria flower drip pill and its preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 《中成药》 19750531 浙江省绍兴地区药品检验所 贝母花流浸膏生产工艺改革探讨 26 , 第05期 2 * |
| 《卫生部颁药品标准中药成方制剂第六册》 19921231 药典委员会 贝母花流浸膏 35 1-2 , 2 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857259A (en) * | 2014-11-20 | 2015-08-26 | 浙江康恩贝制药股份有限公司 | Fritillaria flower extractive, preparation method therefore and applications |
| CN104857259B (en) * | 2014-11-20 | 2018-01-19 | 浙江康恩贝制药股份有限公司 | A kind of fritillaria flower extract and its preparation method and application |
| CN107823135A (en) * | 2017-11-17 | 2018-03-23 | 湖北医药学院 | Peininine nano-emulsion and preparation method and application |
| CN115372501A (en) * | 2022-07-27 | 2022-11-22 | 广州科曼生物科技有限公司 | Thunberg fritillary bulb or Hubei fritillary bulb contrast extract and preparation method and application thereof |
| CN115372501B (en) * | 2022-07-27 | 2024-03-26 | 广州科曼生物科技有限公司 | Control extract of fritillaria thunbergii or fritillaria hubei, preparation method and application thereof |
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Application publication date: 20100728 |