CN101837029A - Nanometer taxus chinensis powder and preparation method thereof - Google Patents
Nanometer taxus chinensis powder and preparation method thereof Download PDFInfo
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- CN101837029A CN101837029A CN200910058646A CN200910058646A CN101837029A CN 101837029 A CN101837029 A CN 101837029A CN 200910058646 A CN200910058646 A CN 200910058646A CN 200910058646 A CN200910058646 A CN 200910058646A CN 101837029 A CN101837029 A CN 101837029A
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- ramulus
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- folium taxi
- taxi cuspidatae
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Abstract
The invention provides a nanometer taxus chinensis product and a preparation method thereof. In the method, the taxus chinensis is taken as a raw material, the latest nano process technology and pure physical method are utilized and the taxus chinensis is crushed into powder through mechanical forces, wherein the average grain diameter of the powder particle is 1-1000 nanometer, thus the cellwall of the taxus chinensis is completely broken, the various components in the taxus chinensis are completely released, the permeability is improved greatly, and the effect and the curative effect are both improved substantially. The invention makes full use of the root, stem, leaves, trunk and bark of the taxus chinensis, is close to zero wastage of raw materials during process, and can greatly save the taxus chinensis resources.
Description
Technical field
The invention belongs to ultra tiny pulverizing processing technique field, relate to a kind of nanometer taxus chinensis product and preparation method thereof.
Background technology
Ramulus et folium taxi cuspidatae (basic taxaceae evergreen shrubs or arbor) is universally acknowledged endangered natural rare plants for anticancer, is China first class of protection plant, also is that endangered plants are treasured in the world.Ramulus et folium taxi cuspidatae is owing to contain anticancer specific medicament---paclitaxel and very precious, paclitaxel is after adriamycin and Platinol cisplatin, present best in the world cancer therapy drug, advanced breast cancer, ovarian cancer, uterus carcinoma, esophageal carcinoma, nasopharyngeal carcinoma, upper gastrointestinal cancer, bladder cancer, lymphatic cancer, carcinoma of prostate, malignant melanoma, tumor of head and neck, cellule type and lung cancer in non-cellule type all there are significant curative effect, are described as " last line of defense of patient with advanced cancer ".Food and drug administration (FDA) goes on the market as the medicine for the treatment of diseases such as advanced ovarian cancer, uterus carcinoma, pulmonary carcinoma at official approval paclitaxel in 1992.China Department of Science and Technology, the Ministry of Finance, the State Administration of Forestry and State Administration of Taxation are in " List of High-tech Products in China " of in JIUYUE, 2000 promulgation, and the affirmation paclitaxel is new high-tech product (numbering a 05030206) encourage growth.Except paclitaxel, also contain the several amino acids and the trace element of taxine, diterpenoids chemical compound and needed by human in the Ramulus et folium taxi cuspidatae, remarkable efficacy is all arranged for hypertension, hyperlipidemia, hyperglycemia, diabetes, rheumatoid, dysuria, menoxenia, postnatal blood stasis, adnexitis, uterine adenomyosis, dysmenorrhea, gonorrhea, nephritis, gastritis, enteritis, hemorrhoid etc.
Utilize the method for Ramulus et folium taxi cuspidatae extraction paclitaxel very low at present to utilization ratio of raw materials, and other contained in the Ramulus et folium taxi cuspidatae a large amount of beneficiating ingredients in the course of processing, have been wasted, cause the significant wastage of taxus resource and paclitaxel price extremely expensively, numerous economic capabilities limited cancer patient can't buy.Other utilize Ramulus et folium taxi cuspidatae to make the method for health tea, health-care cup etc., also are insoluble in water because of paclitaxel, so produce little effect by the method for water logging bubble.Domestic and international various nanometer taxus chinensis product and preparation method thereof have a variety of, but nanometer taxus chinensis powder and preparation method thereof still belongs to initiative.
Summary of the invention
The purpose of this invention is to provide a kind of nanometer taxus chinensis product and preparation method thereof.The present invention with Ramulus et folium taxi cuspidatae as raw material, utilize up-to-date nanofabrication technique, use pure physical method, by mechanicals efforts Ramulus et folium taxi cuspidatae is become powder through behind the coarse powder, comminution by gas stream, nano-pulverization, make the mean diameter of its powder particle reach 1～1000 nanometer, the cell wall that makes Ramulus et folium taxi cuspidatae is by breaking cellular wall fully, allows contained various compositions discharge fully in the Ramulus et folium taxi cuspidatae, penetration is greatly improved, and beneficiating ingredient can directly enter focus.
Can isolate various effective ingredient again by extracting through the nanometer taxus chinensis powder that the present invention makes, reduce the difficulty of extracting.The nanometer taxus chinensis powder that makes through the present invention can also directly use as the raw material of medicine, medical equipment, health product, food etc., not needing again, row extracts, can reach the effect of the various beneficiating ingredients that make full use of Ramulus et folium taxi cuspidatae, effect and curative effect all will increase substantially.
The present invention can make insoluble beneficiating ingredients such as paclitaxel contained in the Ramulus et folium taxi cuspidatae become the stabilized nano granule, is more convenient for oral or injection.
Compared with prior art, the present invention has following tangible advantage: 1, need not add other auxiliary materials in the course of processing, use pure physical method processing, guarantee the pure of goods; 2, Ramulus et folium taxi cuspidatae has been saved precious taxus resource greatly near zero loss in the course of processing; 3, the Ramulus et folium taxi cuspidatae that the present invention utilized comprises its root, stem, leaf, does and bark, and promptly the Ramulus et folium taxi cuspidatae Herb all can utilize, and has both made full use of the beneficiating ingredient at each position of Ramulus et folium taxi cuspidatae, can reduce cost again, reduces the price of goods, and is economical and practical, benefits the people.
The specific embodiment
The specific embodiment of the invention was divided into for three steps: the first step, and utilize pulverizer that Ramulus et folium taxi cuspidatae is pulverized, make the mean diameter of its powder particle reach 50～200 orders; In second step, the Ramulus et folium taxi cuspidatae after utilizing the micropowder datatron with coarse powder is pulverized, and makes the mean diameter of its powder particle reach 2000～8000 orders; The 3rd step, Ramulus et folium taxi cuspidatae after utilizing nano grinder with comminution by gas stream is pulverized, and makes the mean diameter of its powder particle reach 1～1000 nanometer (detection of its particle diameter can be identified by scanning electron microscope, transmission electron microscope, laser particle analyzer or low-angle scattering of X-rays method).
Claims (9)
1. a nanometer taxus chinensis product is characterized in that it being that the mean diameter of its powder particle is 1～1000 nanometer with made powder behind Ramulus et folium taxi cuspidatae process coarse powder, comminution by gas stream, the nano-pulverization.
2. goods according to claim 1 is characterized in that it being to make behind Ramulus et folium taxi cuspidatae process coarse powder, comminution by gas stream, the nano-pulverization.
3. goods according to claim 1, the mean diameter that it is characterized in that powder particle is 1～1000 nanometer.
4. a method of processing Ramulus et folium taxi cuspidatae is characterized in that making the mean diameter of its powder particle reach 1～1000 nanometer with becoming powder behind Ramulus et folium taxi cuspidatae process coarse powder, comminution by gas stream, the nano-pulverization.
5. method according to claim 4 is characterized in that the particulate mean diameter of prepared Ramulus et folium taxi cuspidatae powder is 1～1000 nanometer.
6. according to claim 1,2,4 described coarse powder, it is characterized in that utilizing pulverizer that Ramulus et folium taxi cuspidatae is pulverized, make the mean diameter of its powder particle reach 50～200 orders.
7. according to claim 1,2,4 described comminution by gas stream, the Ramulus et folium taxi cuspidatae after it is characterized in that utilizing the micropowder datatron with coarse powder is pulverized, and makes the mean diameter of its powder particle reach 2000～8000 orders.
8. according to claim 1,2,4 described nano-pulverization, the Ramulus et folium taxi cuspidatae after it is characterized in that utilizing nano grinder with comminution by gas stream is pulverized, and makes the mean diameter of its powder particle reach 1～1000 nanometer.
9. according to claim 1,2,4,5,6,7,8 described Ramulus et folium taxi cuspidatae, refer to root, stem, leaf, the dried and bark of basic taxaceae evergreen shrubs or arbor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910058646A CN101837029A (en) | 2009-03-19 | 2009-03-19 | Nanometer taxus chinensis powder and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910058646A CN101837029A (en) | 2009-03-19 | 2009-03-19 | Nanometer taxus chinensis powder and preparation method thereof |
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| CN101837029A true CN101837029A (en) | 2010-09-22 |
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| CN200910058646A Pending CN101837029A (en) | 2009-03-19 | 2009-03-19 | Nanometer taxus chinensis powder and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247304A (en) * | 2010-05-18 | 2011-11-23 | 粟时献 | Health care cosmetics in nano Chinese yew series and production method thereof |
| CN103202865A (en) * | 2013-04-28 | 2013-07-17 | 朱乃根 | Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof |
| CN104055806A (en) * | 2013-03-20 | 2014-09-24 | 中山市中智药业集团有限公司 | Wall-broken Chinese yew preparation |
| CN104306411A (en) * | 2014-09-24 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Taxus chinensis wall-breaking decoction piece preparation method |
| CN110201009A (en) * | 2019-06-24 | 2019-09-06 | 河北橘井药业有限公司 | The application of Japanese yew powder, the concocting method of Japanese yew powder, taxad medicine wine and its application, drug |
| CN115228583A (en) * | 2022-08-02 | 2022-10-25 | 成都一俊生物科技有限公司 | Nanometer particle Taxus media wall-broken fine powder and its preparation method |
| CN115305151A (en) * | 2022-08-02 | 2022-11-08 | 成都一俊生物科技有限公司 | Nano taxus chinensis series health-care essential oil and preparation method thereof |
-
2009
- 2009-03-19 CN CN200910058646A patent/CN101837029A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247304A (en) * | 2010-05-18 | 2011-11-23 | 粟时献 | Health care cosmetics in nano Chinese yew series and production method thereof |
| CN104055806A (en) * | 2013-03-20 | 2014-09-24 | 中山市中智药业集团有限公司 | Wall-broken Chinese yew preparation |
| CN103202865A (en) * | 2013-04-28 | 2013-07-17 | 朱乃根 | Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof |
| CN104306411A (en) * | 2014-09-24 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Taxus chinensis wall-breaking decoction piece preparation method |
| CN104306411B (en) * | 2014-09-24 | 2017-08-22 | 苏州市天灵中药饮片有限公司 | A kind of preparation method of Chinese yew broken wall medicine materical crude slice |
| CN110201009A (en) * | 2019-06-24 | 2019-09-06 | 河北橘井药业有限公司 | The application of Japanese yew powder, the concocting method of Japanese yew powder, taxad medicine wine and its application, drug |
| CN115228583A (en) * | 2022-08-02 | 2022-10-25 | 成都一俊生物科技有限公司 | Nanometer particle Taxus media wall-broken fine powder and its preparation method |
| CN115305151A (en) * | 2022-08-02 | 2022-11-08 | 成都一俊生物科技有限公司 | Nano taxus chinensis series health-care essential oil and preparation method thereof |
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Open date: 20100922 |