CN103202865A - Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof - Google Patents
Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof Download PDFInfo
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Abstract
The invention relates to Chinese yew micronized particles, a compound for health bath obtained by using micronized Chinese yew particle and a preparation method thereof. The preparation method of the micronized Chinese yew particles comprises the following steps of: mixing Chinese yew bark and/or root and micronized solid auxiliary agent so as to form a solid mixture; and crushing the solid mixture in a micronized manner so as to form mixture particles with particle sizes D(90) being smaller than or equal to 15 microns. According to the micronized method disclosed by the invention, the dissolution rate of effective constituents of Chinese yew bark and root is greatly improved, the utilization ratio of Chinese yew bark and root is greatly improved, the adhesion and blockage conditions in crushing are also reduced, the medicine loss is few, and the crushing efficiency of micronized medicine can be obviously improved.
Description
Technical field
The present invention relates to Ramulus et folium taxi cuspidatae micronized particle, the compositions that contains this micronized particle that is used for the health care bathing, health-care lotion and preparation method thereof.Micronized particle of the present invention not only greatly improves the dissolution of rare Ramulus et folium taxi cuspidatae peel of stem and root effective ingredient thereof, greatly improve the utilization rate of Ramulus et folium taxi cuspidatae peel of stem and root, also reduce bonding, clogging in pulverizing, also can significantly improve the crush efficiency of micronized medicine.
Background technology
The Ji Yuan of Ramulus et folium taxi cuspidatae is taxaceae (Taxaceae), the Chinese yew genus plants Ramulus et folium taxi cuspidatae.Existing 4 kinds of China and 1 mutation, be Chinese Ramulus et folium taxi cuspidatae (Taxus chinensis(Pilger) Rehd.), Ramulus et folium taxi cuspidatae, T. yunnanensis (T.YUENNAN ENSIS CHENG ET L.K.FU), Xizang Taxus chinensis (T.WALL ICHIANA IUCC) and Taxus mairei (T.CHINENSIS VAR MAIREI(LEMEE ET L ' EVL) CHENG ET L.K.FU) (mutation), extensively be distributed in ground such as China's SOUTH OF GANSU, south, Shaanxi, western part, Hubei, Sichuan.Ramulus et folium taxi cuspidatae also can manually be planted, and national most of area all can be planted, and there is extensive cultivation on ground such as Sichuan, Guangxi, Shandong, Fujian now.
Ramulus et folium taxi cuspidatae is quaternary glacier Relict Plant in period, world rare and endangered species, and taxus resource should add protection, and the United Nations also prohibites felling.It likes dark and damp environment, warm and humid climate, not only has drought-enduring cold-resistant, disease and insect resistance, stronger rudiment ability, and poor growth, characteristics such as life-span length, and have high value of exploiting and utilizing.The paclitaxel that extracts from bark of Ramulus et folium taxi cuspidatae and branch and leaf is the medicament of the cancer-resisting of generally acknowledging in the world; Paclitaxel is used for the treatment of advanced breast cancer, pulmonary carcinoma, ovarian cancer and incidence cancer, soft tissue cancer and digestive tract cancer.Ramulus et folium taxi cuspidatae is used for the treatment of leukemia, nephritis, diabetes and POLYCYSTIC KIDNEY DISEASE.It also has effects such as inducing diuresis to remove edema, treatment nephropathy, diabetes, nephritis edema, dysuria, gonorrhea.Also find by research: root is the highest organ of content of taxol except bark.
Domestic micronizing is a new and high technology that develops rapidly the eighties in 20th century, refers to utilize machinery or hydrokinetic approach that raw material is processed into micropowder or even nano powder.To the later stage nineties, at the field of Chinese medicines, superfine communication technique is also progressively opened up the combination of advanced crushing technology and Chinese medicine, improved the quality of Chinese medicinal powder, improve the utilization rate of Chinese medicine, increased dissolution of composition etc., represented wide application prospect.Domestic to many single medicinal materials, carried out micronizing research as Cordyceps, Ganoderma spore, pollen, Cornu Saigae Tataricae, Rhizoma Coptidis, Radix Notoginseng, Rhizoma Gastrodiae, Cornu Cervi Pantotrichum, Margarita, Radix Ginseng Rubra, Radix Panacis Quinquefolii, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Placenta Hominis, Folium Mori, the Rhizoma Anemarrhenae, Radix Puerariae, Fructus Aurantii, Herba Houttuyniae, Hirudo etc.Because the specific surface area of ultrafine powder is bigger, improved dissolution and the bioavailability of Chinese medicine; Strengthened the drug effect of Chinese medicine; Can reduce dosage, conservation is raised the efficiency, and reduces cost.
Drug micronization has several different methods, comprising comminution by gas stream, ball-milling method, ultrasonic method, spray drying method, supercritical fluid technology etc.Micropowder has strong reunion tendency in preparation, storage process, because intergranular exists Van der Waals force, liquid bridge power, electrostatic force etc.Some drug micronization methods are dissolved or dispersion medicine by adding liquid medium (as water, ethanol etc.), the bonding phenomenon that produces when clashing into mutually with the electrostatic interaction, Van der Waals force or the drug particles that reduce or eliminate drug powder.Yet the micronized medicine of this wet method preparation need be removed liquid medium with modes such as spray drying, vacuum drying or microwave drying usually, just can obtain solid drugs.Yet this process exists that medicine instability, drug particle size are wayward, difficulty is produced in coalescent, medicine crystal phase transition, organic solvent residual, amplification to drug particle again, energy consumption is big and efficient is low, production cost increases even have shortcoming such as potential safety hazard.Especially also need to slough the liquid medium that adds, so cause the operating time long and complicated.Therefore, do not add any liquid medium, it is a kind of method simply fast that the solid drugs powder is directly carried out micronization.Yet a lot of medical solid powder are directly pulverized also and are had problems, such as: with comminution by gas stream directly pulverizing can have shortcomings such as coalescent, obstruction tract, efficient are low; And with ball-milling method directly pulverizing can have adhesion, shortcomings such as knot cake, weak effect.These shortcomings all can cause the drug powder metallization processes can not scale and industrialization, even all can't carry out at laboratory.
Micronizing mainly adopts abrading type disintegrator, mechanical impact crusher, jet mill etc. at present.
Summary of the invention
Purpose of the present invention just provides the method for micronization that is applicable to Ramulus et folium taxi cuspidatae peel of stem and root that a kind of technology is easy, efficient is high.By Ramulus et folium taxi cuspidatae peel of stem and root are carried out the micronizing processing, can improve the dissolution of paclitaxel, conservation is raised the efficiency, and reduces cost, and is to the rare resource of protection Ramulus et folium taxi cuspidatae, significant.Specifically be in the micronization technology of prepared slices of Chinese crude drugs Ramulus et folium taxi cuspidatae peel of stem and root, by adding a certain amount of micronization auxiliary agent, improve micronization efficient greatly, and can prevent shortcoming such as pipeline obstruction in the comminution by gas stream effectively, drug loss is little, and makes particle diameter D (90) and be less than or equal to 10 microns drug microparticles.
A first aspect of the present invention, a kind of Ramulus et folium taxi cuspidatae micronized particle is provided, its be by will dry to moisture be 4.0 weight %(namely, the content of the moisture in Taxus peel of stem and/or the root) below, following Taxus peel of stem and/or the root of preferred 3.0 weight % (is preferably the coarse powder of Taxus peel of stem and/or root, for example Ramulus et folium taxi cuspidatae peel of stem and/or undercut are become 1.0～4.0 millimeters of thickness, preferred 1.8～2.2 millimeters, root diameter or skin length are 2.0～20.0 millimeters, preferred 5.0～20.0 millimeters, preferred 10.0～12.0 millimeters and the coarse powder that obtains, perhaps minor axis is 1.0～4.0 millimeters, preferred 1.8～2.2 millimeters, 5.0～20.0 millimeters of major diameters, preferred 10.0～12.0 millimeters coarse powder.Preferably; coarse powder is crossed 10～80 mesh sieves; preferred 40～80 mesh sieves of crossing; more preferably cross 60 mesh sieves) with solid-state micronization auxiliary agent according to 100:10～40(Taxus peel of stem and/or root: solid-state micronization auxiliary agent); preferred 100:10～30; more preferably the weight ratio of 100:15～25 is mixed; form solid mixt; then described solid mixt being carried out micronization pulverizes; make particle diameter D (90) be less than or equal to 15 microns, preferably be less than or equal to 10 microns or 8 microns (for example in 1～10 micrometer range or in 1～5 micrometer range) and the granulate mixture that obtains.
Wherein, the Ji Yuan of described Ramulus et folium taxi cuspidatae is taxaceae (Taxaceae), can be any one or two or more mixture, for example Chinese Ramulus et folium taxi cuspidatae (Taxus chinensis(Pilger) Rehd. in the Ramulus et folium taxi cuspidatae), Ramulus et folium taxi cuspidatae, T. yunnanensis (T.Yuennan Ensis Cheng ET L.K.FU), Xizang Taxus chinensis (T.Wall Ichiana IUCC) and Taxus mairei (T.Chinensis VAR Mairei(LEMEE ET L ' EVL) Cheng ET L.K.FU) any one or two or more mixture in (mutation).From the angle of protection Chinese yew, should select above Ramulus et folium taxi cuspidatae of ten ages of cultivation for use.
Prepare the required raw material of Ramulus et folium taxi cuspidatae micronized particle of the present invention and can get peel of stem, root or the peel of stem of Ramulus et folium taxi cuspidatae and the mixture of root.When getting the mixture of peel of stem and root, to both weight ratio without limits, preferred peel of stem and root be with weight ratio 100: 50-100:200, or 100: 80-100:180, or 100: 100-100:150 mixes.
Described solid-state micronization auxiliary agent refers to assist the micronization of Ramulus et folium taxi cuspidatae peel of stem and/or root, plays the reagent that prevents from blocking pulverizing chamber and gas channel when comminution by gas stream is handled.Preferentially be selected from Sal (especially powdery Sal), silicon dioxide, the medicinal Pulvis Talci one or more.Because not adding liquid medium in the described method, avoided that drug particle size is wayward, drug particle shortcomings such as difficulty is produced in coalescent, organic solvent residual, amplification again, energy consumption is big and efficient is low.Sal is as the part of micronization auxiliary agent, and the Sal molecule is polar molecule, the cementation that produces when electrostatic interaction, Van der Waals force or the drug particles that can reduce drug powder clashes into mutually.Also improved comminution by gas stream directly pulverizing can exist coalescent, stop up shortcomings such as tract, efficient are low.When solid-state micronization auxiliary agent was lower than 10 weight portions with respect to 100 weight portion Taxus peel of stem and/or root, auxiliary micronized effect was insufficient, and when surpassing 30 weight portions, did not produce bigger auxiliary micronized effect.
More preferably, described solid-state micronization auxiliary agent is the composite solid micronization auxiliary agent that Sal, medicinal Pulvis Talci are formed, be that medicine (Taxus peel of stem and/or root) is about (but being not limited to) 100: 5～20: 5～20 with Sal, medicinal Pulvis Talci weight ratio, preferred 100: 8～15: 8～15, most preferably from about 100: 10: 10, at this moment, the micronization crushing operation is smooth and easy, effect satisfied.Add a spot of Sal and namely help micronization, and can play the effect of normal saline in putting into body lotion the time, be in harmonious proportion medicine.When using single solid-state micronization auxiliary agent of planting such as Sal (especially powdery Sal), silicon dioxide, medicinal Pulvis Talci, the weight ratio of medicine (Taxus peel of stem and/or root) and any solid-state micronization auxiliary agent (as Sal (especially powdery Sal), silicon dioxide or medicinal Pulvis Talci) is about 100: 10～and 40, preferred 100: 15～30, most preferably 100: 18～25, for example 100: 20.
Preferably, solid-state micronization auxiliary agent with dry in advance to moisture 5.0 weight % before Ramulus et folium taxi cuspidatae peel of stem and/or root mix, below the preferred 4.0 weight %, more preferably below the 3.0 weight %.
Described method of micronization can be the method for micronization of not annex solution body medium commonly used, for example comminution by gas stream, ball-milling method, ultrasonic method, spray drying method etc.Preferred comminution by gas stream.
Comminution by gas stream is to utilize the energy of high velocity air to make granule produce impact, collision and friction each other, thereby causes a kind of superfine technique of breakage of particles refinement.Being different from mechanical activation comminution and relying on blade or tup etc. to the impact comminution of material, is that a kind of low temperature does not have medium and pulverizes, and the production process clean environment firendly is particularly suitable for thermal sensitivity, low melting point, contains the pulverizing of sugar part and volatile material.
Be applicable to that airflow pulverization method of the present invention and device are not particularly limited, can adopt commercially available air flow crushing device, and carry out comminution by gas stream according to the conditioned disjunction parameter of manufacturer's suggestion.
Second aspect of the present invention provides a kind of preparation method of Ramulus et folium taxi cuspidatae micronized particle, described method comprise with dry to moisture be below the 4.0 weight %, following Taxus peel of stem and/or the root of preferred 3.0 weight % (is preferably the coarse powder of Taxus peel of stem and/or root, for example Ramulus et folium taxi cuspidatae peel of stem and/or undercut are become 1.0～4.0 millimeters of thickness, preferred 1.8～2.2 millimeters, root diameter or skin length are 2.0～20.0 millimeters, preferred 5.0～20.0 millimeters, preferred 10.0～12.0 millimeters and the coarse powder that obtains, perhaps minor axis is 1.0～4.0 millimeters, preferred 1.8～2.2 millimeters, 5.0～20.0 millimeters of major diameters, preferred 10.0～12.0 millimeters coarse powder.Preferably, coarse powder is crossed 10～80 mesh sieves, preferred 40～80 mesh sieves of crossing, more preferably cross 60 mesh sieves) with solid-state micronization auxiliary agent according to 100:10～40(Taxus peel of stem and/or root: solid-state micronization auxiliary agent), preferred 100:10～30, more preferably the weight ratio of 100:15～25 is mixed, form solid mixt, then described solid mixt is carried out micronization and pulverize, make particle diameter D (90) be less than or equal to 15 microns, preferably be less than or equal to 10 microns or 8 microns.
In said method, the Ji Yuan of described Ramulus et folium taxi cuspidatae is taxaceae (Taxaceae), can be any one or two or more mixture, for example Chinese Ramulus et folium taxi cuspidatae (Taxus chinensis(Pilger) Rehd. in the Ramulus et folium taxi cuspidatae), Ramulus et folium taxi cuspidatae, T. yunnanensis (T.Yuennan Ensis Cheng ET L.K.FU), Xizang Taxus chinensis (T.Wall Ichiana IUCC) and Taxus mairei (T.Chinensis VAR Mairei(LEMEE ET L ' EVL) Cheng ET L.K.FU) any one in (mutation) or two or more mixture.From the angle of protection Chinese yew, should select above Ramulus et folium taxi cuspidatae of ten ages of cultivation for use.
In the described preparation method, raw material can be got peel of stem, root or the peel of stem of Ramulus et folium taxi cuspidatae and the mixture of root.When getting the mixture of peel of stem and root, to both weight ratio without limits, preferred peel of stem and root be with weight ratio 100: 50-100:200, or 100: 80-100:180, or 100: 100-100:150 mixes.
Described solid-state micronization auxiliary agent preferentially is selected from one or more in Sal (especially powdery Sal), silicon dioxide, the medicinal Pulvis Talci.
Preferably, described solid-state micronization auxiliary agent is the composite solid micronization auxiliary agent that Sal, medicinal Pulvis Talci are formed, be that medicine and Sal, medicinal Pulvis Talci weight ratio are about 100: 5～20: 5～20 (but being not limited to), preferred 100: 8～15: 8～15, most preferably from about 100: 10: 10, at this moment, the micronization crushing operation is smooth and easy, effect satisfied.Add a spot of Sal and namely help micronization, and can play the effect of normal saline in putting into body lotion the time, be in harmonious proportion medicine.
Preferably, solid-state micronization auxiliary agent with dry in advance to moisture 5.0 weight % before Ramulus et folium taxi cuspidatae peel of stem and/or root mix, below the preferred 4.0 weight %, more preferably below the 3.0 weight %.
Described method of micronization can be the method for micronization of not annex solution body medium commonly used, for example comminution by gas stream, ball-milling method, ultrasonic method, spray drying method etc.Preferred comminution by gas stream.
Third aspect of the present invention provides a kind of compositions for the health care bathing, described compositions comprises Radix Astragali prepared slices of Chinese crude drugs component and above Ramulus et folium taxi cuspidatae micronized particle component of the present invention or by the prepared Ramulus et folium taxi cuspidatae micronized particle component of method of the present invention, the weight ratio of two kinds of components is 50:10～150, preferred 50:40～60, preferred 50:45～55, more preferably 50:50 for example.Or, described compositions comprises by water or ethanol water carries out lixiviate and concentrates the extract that obtains then Chinese medicine astragalus decoction pieces component and above-mentioned Ramulus et folium taxi cuspidatae micronized particle component, wherein the weight ratio of Ramulus et folium taxi cuspidatae micronized particle component and Chinese medicine astragalus decoction pieces is 50:10～150, preferred 50:30～100, preferred 50:40～60, preferred 50:45～55, more preferably 50:50 for example.Here two kinds of compositionss are respectively the form of solid or liquid.
Described compositions for the health care bathing is monarch with the Ramulus et folium taxi cuspidatae, diuresis is arranged, stimulates the menstrual flow, the effect (" Chinese medicine voluminous dictionary " 2342 pages) of blood fat reducing.Be minister with the Radix Astragali, benefit is defended consolidating superficial resistance, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema.Assistant has relieving stranguria by diuresis with Pulvis Talci, the clearing away summer-heat effect.More with a little Sal for making, be in harmonious proportion all flavor property of medicine, have the effect of similar normal saline concurrently.
Form (solid or liquid) for the method for preparing above-mentioned composition, above-mentioned composition is not particularly limited.For example a kind of preferred manufacturing procedure comprises:
(1) with the micronized particle of Ramulus et folium taxi cuspidatae peel of stem of the present invention and/or root, carries out the compound membrane bag packing, every bag 50 gram.
(2) with the Radix Astragali prepared slices of Chinese crude drugs, carry out the compound membrane bag packing, every bag 10～150 gram, preferred 40～60 grams, preferred 45～55 grams, for example 50 grams.
(3) two bags of medicines of step (1) and (2) are formed compound (solid composite).
Perhaps, in another embodiment, above-mentioned compositions for the health care bathing can be by micronized particle 100 weight portions and Radix Astragali decoction pieces 10～150 weight portions (the preferred 30-100 weight portion with Ramulus et folium taxi cuspidatae peel of stem and/or root, preferred 40～60 weight portions, preferred 45～55 weight portions) together in water or ethanol water (30～75 quality % aqueous solutions of ethanol for example, 45～75 quality % aqueous solutions, 75 quality % aqueous solutions) lixiviate at normal temperatures is for example 10～24 hours or boiling under the state lixiviate for example 5 minutes～1 hour in, isolate liquid again, randomly concentrating (for example be concentrated into original volume 3/4～1/2) packs afterwards, obtain the fluid composition for the health care bathing of the present invention, the amount that wherein is used for the water of lixiviate or ethanol water is 5 times～12 times of dry weight of the micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root and Radix Astragali decoction pieces, preferred 6～10 times.
The application process of described solid composite is:
With above-mentioned solid composite (micronized particle of 50g Ramulus et folium taxi cuspidatae peel of stem and/or root and 10～150g, preferred 40～60 gram Radix Astragali decoction pieces) brew with the drinking water that boils, for example brew into 100 liters, covered and enclosed a period of time, for example 10 minutes, namely make health-care lotion, can be used for Saunas, dipping bath, shower etc., be preferred for Saunas, dipping bath.As being used for health-care foot bath, the consumption of the micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root and Radix Astragali decoction pieces takes the circumstances into consideration to reduce by half.
Compositions for the health care bathing of the present invention have elimination skin pruritus (antipruritic), obviously improve sleep, relieving fatigue, diuresis perspire, dredge the meridian passage, go the painful abdominal mass relieving distension, alleviate the effect of the stiff and pain of skeleton, be particularly useful for skin pruritus, fatigue, sleep disorder, myasthenia of limbs, ache all over, the skin pruritus of diabetic dermopathy, chronic kidney decay etc.
Advantage of the present invention further comprises:
(a) micronisation process of the present invention can effectively reduce phenomenons such as the bonding of pressed powder in directly pulverizing, obstruction.
(b) micronization technology of the present invention is simple, crush efficiency is high, loss is few.
(c) drug microparticles of the present invention promotes micronized effect more obvious owing to added the composite micro-powder auxiliary agent, and medicinal Pulvis Talci is one of active ingredient of health-care foot bath or Saunas, and a small amount of Sal then has the effect of similar normal saline.
(d) with the pharmaceutical composition of drug microparticles of the present invention preparation, extract under (boiled water dashes and stirs) simplifying, need not decoct again, processing such as lixiviate; The drug dissolution height greatly improves the effective rate of utilization of rare Ramulus et folium taxi cuspidatae peel of stem and root, and is to the rare resource of protection Ramulus et folium taxi cuspidatae, significant.Micronization generally can be saved Ramulus et folium taxi cuspidatae medical material 30%～70%, has reduced the wasting of resources.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment pick out representative classics research paragraph from the numerous experiments of the present invention, they only are not used in for explanation the present invention and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example usually according to normal condition, or carries out according to the condition that manufacturer advises.
Wherein, in the embodiment of the invention, used Ramulus et folium taxi cuspidatae peel of stem and root are all dried to moisture below 4.0%.
The used solid-state micronization auxiliary agent of the present invention, Sal and medicinal Pulvis Talci or silicon dioxide are dried to moisture below 4.0%.
The envionmental humidity of micronization that the present invention carries out experiment remains on below 30% as far as possible.
Ramulus et folium taxi cuspidatae of the present invention is selected from above Chinese yew of ten ages of cultivation.
Comparative Examples 1: the prepared slices of Chinese crude drugs mixture to Ramulus et folium taxi cuspidatae peel of stem and root directly carries out comminution by gas stream.
After the prepared slices of Chinese crude drugs mixture coarse powder of Ramulus et folium taxi cuspidatae peel of stem and root crossed 60 mesh sieves, do not add any medium (micronization auxiliary agent), directly carry out the dry method micronization with jet mill (the JGM-H200 type jet mill of Huali Co., Ltd) and pulverize, pulverize the about 5-8bar of pressure.Granularity after the pulverizing is that D (50) is 256.8 μ m, and D (90) is 874.6 μ m, does not reach the micronization effect.
Found that the coarse powder of Ramulus et folium taxi cuspidatae peel of stem and root very easily sticks in the pulverizing chamber, stop up pulverizing chamber and high pressure draught passage, influence crush efficiency, even pulverizing can't be carried out smoothly.Jet mill is taken apart, and finding has floccule and paste in the crushing chamber, and water cleans, and then oven dry.Thoroughly the micronization pulverizing is continued in the cleaning back, the same bonding blockage problem that exists.
Embodiment 1: the common micronization of coarse powder that adds solid-state micronization auxiliary agent Sal and Ramulus et folium taxi cuspidatae peel of stem, root is pulverized.
Coarse powder and the 100g Sal coarse powder (medicine and solid-state micronization auxiliary agent weight ratio are about 100: 20) of 500g Ramulus et folium taxi cuspidatae peel of stem, root are crossed 60 mesh sieves respectively, mix the back and carry out the micronization pulverizing with jet mill (the JGM-H200 type jet mill of Huali Co., Ltd), pulverize pressure and be about 6-8bar, feed rate is 50 ━ 75g/min, and micronization processes once.The micronization crushing operation is smooth and easy.Receive micronized medicine 588.6g, yield is 98.1%.
With the particle size distribution of Ma Erwen Particle Size Analyzer mensuration micronization material, the result shows that D (50) is 5.6 μ m, and D (90) is 12.4 μ m.
With coarse powder and the common micronization of micronization auxiliary agent Sal of Ramulus et folium taxi cuspidatae peel of stem, root, micronization efficient height, effective, do not see clogging.
Embodiment 2: the common micronization of coarse powder that adds solid-state micronization auxiliary agent medicinal Pulvis Talci and Ramulus et folium taxi cuspidatae peel of stem, root is pulverized.
Coarse powder and the 100g medicinal Pulvis Talci coarse powder (medicine and solid-state micronization auxiliary agent weight ratio are about 100: 20) of 500g Ramulus et folium taxi cuspidatae peel of stem, root are crossed 60 mesh sieves respectively, mix the back and carry out the micronization pulverizing with jet mill (the JGM-H200 type jet mill of Huali Co., Ltd), pulverize pressure and be about 6-8bar, feed rate is 50 ━ 75g/min, and micronization processes once.The micronization crushing operation is smooth and easy.Receive micronized medicine 590.4g, yield is 98.4%.
With the particle size distribution of Ma Erwen Particle Size Analyzer mensuration micronization material, the result shows that D (50) is 5.2 μ m, and D (90) is 9.2 μ m.In the jet mill tract, do not see the bonding phenomenon behind the micronization.
Embodiment 3: the common micronization of coarse powder that adds solid-state micronization auxiliary agent silicon dioxide and Ramulus et folium taxi cuspidatae peel of stem, root is pulverized.
Coarse powder and the 100g silicon dioxide coarse powder (medicine and solid-state micronization auxiliary agent weight ratio are about 100: 20) of 500g Ramulus et folium taxi cuspidatae peel of stem, root are crossed 60 mesh sieves respectively, mix the back and carry out the micronization pulverizing with jet mill (the JGM-H200 type jet mill of Huali Co., Ltd), pulverize pressure and be about 6-8bar, feed rate is 50 ━ 75g/min, and micronization processes once.The micronization crushing operation is smooth and easy.Receive micronized medicine 589.5g, yield is 98.2%.
With the particle size distribution of Ma Erwen Particle Size Analyzer mensuration micronization material, the result shows that D (50) is 5.1 μ m, and D (90) is 9.0 μ m.In the jet mill tract, do not see the bonding phenomenon behind the micronization.
Embodiment 4: the common micronization of coarse powder that adds composite solid micronization auxiliary agent Sal, medicinal Pulvis Talci and Ramulus et folium taxi cuspidatae peel of stem, root is pulverized.
Coarse powder and 50g Sal, the 50g medicinal Pulvis Talci coarse powder (medicine and solid-state micronization auxiliary agent weight ratio are about 100: 10: 10) of 500g Ramulus et folium taxi cuspidatae peel of stem, root are crossed 60 mesh sieves respectively, mix the back and carry out the micronization pulverizing with jet mill (the JGM-H200 type jet mill of Huali Co., Ltd), pulverize pressure and be about 6-8bar, feed rate is 50-75g/min, and micronization processes once.The micronization crushing operation is smooth and easy.Receive micronized medicine 587.8g, yield is 98.0%.
With the particle size distribution of Ma Erwen Particle Size Analyzer mensuration micronization material, the result shows that D (50) is 5.0 μ m, and D (90) is 9.2 μ m.In the jet mill tract, do not see the bonding phenomenon behind the micronization.
Sal, medicinal Pulvis Talci, silicon dioxide or its any compositions are as composite solid micronization auxiliary agent, and ratio does not have strict restriction, pulverize with the common micronization of the coarse powder of Ramulus et folium taxi cuspidatae peel of stem, root, through long run test, do not see bonding or clogging in the jet mill tract.The micronization crushing operation is smooth and easy.JGM-H200 type jet mill with Huali Co., Ltd carries out the micronization pulverizing, and after crushing operation was skilled, feed rate can reach 75 ━ 90g/min, and micronized drug particle size all satisfies the granularity requirements of expection.The micronization yield all reaches about 98.0%.Illustrate that this micronization technology can amplify production.
Embodiment 5 is used for the solid composite of health care bathing
With the micronized particle of above-described embodiment 4 formed Ramulus et folium taxi cuspidatae peel of stem and root, carry out the compound membrane bag packing, every bag 50 gram.
With the Radix Astragali prepared slices of Chinese crude drugs, carry out the compound membrane bag packing again, every bag 50 gram.
Above-mentioned two bags of medicines are formed compound taxol health-care lotion solid composite.
Compound taxol health-care lotion solid composite with above-mentioned two bags of medicines are formed brews into 100 liters with the Drink water that boils, and covered and enclosed 10 minutes namely makes health-care lotion, can be used for Saunas.Health-care foot bath takes the circumstances into consideration to reduce by half.
Embodiment 6 is used for the fluid composition of health care bathing
The micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root and Radix Astragali decoction pieces were being boiled under the state lixiviate 10 minutes together in 10 times of water gagings of the dry weight of the micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root and Radix Astragali decoction pieces, isolate liquid (lixiviating solution), reconcentration to the lixiviating solution original volume 1/2 after pack, obtain of the present invention for the health care bathing fluid composition.
The aforesaid liquid compositions is added 100ml aforesaid liquid compositions in 100 liters of hot water for bathing, namely make health-care lotion, can be used for dipping bath, shower, Saunas, health-care foot bath etc.
Embodiment 5 and embodiment 6 described compositionss for the health care bathing are monarch with the Ramulus et folium taxi cuspidatae, diuresis is arranged, stimulate the menstrual flow, the effect (" Chinese medicine voluminous dictionary " 2342 pages) of blood fat reducing.Be minister with the Radix Astragali, benefit is defended consolidating superficial resistance, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema.Assistant has relieving stranguria by diuresis with Pulvis Talci, the clearing away summer-heat effect.More with a little Sal for making, be in harmonious proportion all flavor property of medicine, have the effect of similar normal saline concurrently.Health-care lotion that compositions makes is arranged applicable to improving sleep, relieving fatigue, the painful abdominal mass relieving distension is gone in the diuresis perspire, dredge the meridian passage, enhances metabolism.
According to the rough estimates that data is arranged, health-care lotion Saunas with the solid health-care preparation of compositions of embodiment 5, be applicable to that above-mentioned sign treats 376 examples (comprising fatigue and weak, skin pruritus, intractable sleep disorder, diabetic dermopathy person, the person of aching all over), produce effects (symptom is eliminated fully) 161 examples, effective (symptom is obviously improved) 201 examples, invalid 14 examples, total effective rate 96%.Patient's Saunas once each 1 hour, just can obviously improve sleep, relieving fatigue, diuresis perspire, dredge the meridian passage, the stiff and pain of alleviation skeleton.Saunas is 3 times next day of continuously, and the patient reflects that generally whole body is light, the spirit multiplication, and above-mentioned many symptoms all disappear.
Model case 1: Pan, the machine-operated civil servant in Fuding City, Fujian Province, man, 55 years old.Be busy with one's work, the work of staying up late of often working extra shifts or extra hours quite takes energy again, causes insomnia cardiopalmus, neurolysis, and gastrointestinal upset, abdominal distention and anorexia, the serious overdraw of muscle power is sharp.Patient's Saunas once, about 1 hour, patient's readme was sleeping sedate, the tired releasing, whole body is light, the spirit multiplication, the abdominal distention sense disappears, the intestines and stomach digestion is normal substantially.
Model case 2: surplus certain, the civilian of Fuding City, Fujian Province, man, 38 years old.Long-time computer work.Stiff and the pain of neck and shoulder part skeleton unbearably.The next day continuous Saunas 3 times, the stiff and pain of patient's readme neck and shoulder part skeleton disappears, activity freely, and is evident in efficacy.
Model case 3: swim certain, people from Taishun County, Zhejiang Province, rural migrant worker.The man, 38 years old.The work of outdoor long period of summer-heat sky, malaise, Mian Se Cang is white, and abdomen is every distension, soreness of waist and knee joint, dizzy pupil.After drinking hot boiled water, take and this product Saunas through full Shen Pinch, of pink and healthy-looking, abdomen disappears every distension, antisecosis such as preceding.
Model case 4: journey, Zhejiang Province's dragon's fountain people from county, retirement is in.The woman, 68 years old.12 years diabetic history are arranged.Intractable skin pruritus 4 years, especially with the autumn and winter for very, the pruritus influence is fallen asleep.Through 10% glycerol, the soft cream of Strong etc. is smeared treatment and Chinese medicine for oral administration is not healed repeatly.Through this health-care lotion Saunas, every other day once, continuous five times, skin pruritus is removed, and is steadily sleeping.Not recurrence in nine months.
Claims (10)
1. Ramulus et folium taxi cuspidatae micronized particle; its be by will dry to moisture be below the 4.0 weight %; the Taxus peel of stem that preferred 3.0 weight % are following and/or root and solid-state micronization auxiliary agent are according to 100:10～40; preferred 100:10～30; more preferably the weight ratio of 100:15～25 is mixed; form solid mixt; then described solid mixt being carried out micronization pulverizes; make particle diameter D (90) be less than or equal to 15 microns, preferably be less than or equal to 10 microns or 8 microns and the granulate mixture that obtains.
2. Ramulus et folium taxi cuspidatae micronized particle according to claim 1, wherein, described Ramulus et folium taxi cuspidatae is any one or the two or more mixture in Chinese Ramulus et folium taxi cuspidatae, Ramulus et folium taxi cuspidatae, T. yunnanensis, Xizang Taxus chinensis, the Taxus mairei; And/or wherein solid-state micronization auxiliary agent is selected from one or more in Sal (especially powdery Sal), silicon dioxide, the medicinal Pulvis Talci.
3. Ramulus et folium taxi cuspidatae micronized particle according to claim 1 and 2, wherein, the weight ratio 100 of Ramulus et folium taxi cuspidatae peel of stem and root: 50-100:200, preferred 100: 80-100:180, or 100: 100-100:150.
4. according to each described Ramulus et folium taxi cuspidatae micronized particle of claim 1～3, wherein with respect to 100 weight portion Taxus peel of stem and/or roots, the micronization auxiliary agent is 5～20 weight portions, preferred 10 weight portion Sal and 5～20 weight portions, preferred 10 weight portion medicinal Pulvis Talci.
5. according to each described Ramulus et folium taxi cuspidatae micronized particle of claim 1～4, wherein the moisture of solid-state micronization auxiliary agent is below the 5.0 quality %, below the preferred 4.0 quality %, more preferably below the 3.0 quality %.
6. according to each described Ramulus et folium taxi cuspidatae micronized particle of claim 1～5, wherein any one in comminution by gas stream, ball-milling method, ultrasonic method, the spray drying method passed through in the micronization pulverizing, and preferred comminution by gas stream carries out.
7. the method for preparing each described Ramulus et folium taxi cuspidatae micronized particle of claim 1～6, described method comprise with dry to moisture be below the 4.0 weight %, the Taxus peel of stem that preferred 3.0 weight % are following and/or root and solid-state micronization auxiliary agent are according to 100:10～40, preferred 100:10～30, more preferably the weight ratio of 100:15～25 is mixed, form solid mixt, then described solid mixt being carried out micronization pulverizes, make particle diameter D (90) be less than or equal to 15 microns, preferably be less than or equal to 10 microns or 8 microns.
8. compositions that is used for the health care bathing, described compositions comprises each described Ramulus et folium taxi cuspidatae micronized particle component of Chinese medicine astragalus decoction pieces component and claim 1～6 or passes through the prepared Ramulus et folium taxi cuspidatae micronized particle component of method of claim 7, the weight ratio of Ramulus et folium taxi cuspidatae micronized particle component and Chinese medicine astragalus decoction pieces is 50:10～150, preferred 50:40～60, preferred 50:45～55, more preferably 50:50 for example.
9. prepare the method for compositions of claim 8, it comprises:
(1) each described Ramulus et folium taxi cuspidatae peel of stem of claim 1～6 and/or the micronized particle of root are carried out the compound membrane bag packing, every bag 50 gram;
(2) with the Radix Astragali prepared slices of Chinese crude drugs, carry out the compound membrane bag packing, every bag 10～150 gram, preferred 40～60 grams, most preferably 45～55 grams, for example 50 grams;
(3) two bags of medicines of step (1) and (2) are formed compound.
10. the method for compositions for preparing claim 8, it comprises: with the lixiviate at normal temperatures for example 10～24 hours or boiling under the state lixiviate for example 5 minutes～1 hour in water or in the ethanol water together of the micronized particle of each described Ramulus et folium taxi cuspidatae peel of stem of claim 1～6 and/or root and Radix Astragali decoction pieces, isolate liquid again, randomly concentrating (for example be concentrated into original volume 3/4～1/2) packs afterwards, obtain to be used for the fluid composition of health care bathing, the amount that wherein is used for the water of lixiviate or ethanol water is 5 times～12 times of dry weight of the micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root and Radix Astragali decoction pieces, preferred 6～10 times.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103479685A (en) * | 2013-09-26 | 2014-01-01 | 陈益飞 | Foot bath lotion |
| CN103585200A (en) * | 2013-09-26 | 2014-02-19 | 陈益飞 | Foot bath powder |
| CN104587509A (en) * | 2014-02-19 | 2015-05-06 | 朱乃根 | Compound taxus chinensis drug multifunction baking basket |
| CN108815208A (en) * | 2018-04-02 | 2018-11-16 | 孙向勇 | Health care fermentation wood powder |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479685A (en) * | 2013-09-26 | 2014-01-01 | 陈益飞 | Foot bath lotion |
| CN103585200A (en) * | 2013-09-26 | 2014-02-19 | 陈益飞 | Foot bath powder |
| CN104587509A (en) * | 2014-02-19 | 2015-05-06 | 朱乃根 | Compound taxus chinensis drug multifunction baking basket |
| CN108815208A (en) * | 2018-04-02 | 2018-11-16 | 孙向勇 | Health care fermentation wood powder |
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| CN103202865B (en) | 2014-07-09 |
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