CN102641308A - Taxus chinensis var mairei Chinese herbal material as well as processing method and application thereof - Google Patents
Taxus chinensis var mairei Chinese herbal material as well as processing method and application thereof Download PDFInfo
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Abstract
The invention relates to a taxus chinensis var mairei Chinese herbal material, as well as a processing method and application thereof and belongs to the technical field of Chinese herbal medicine processing. The processing method of the taxus chinensis var mairei Chinese herbal material comprises the following steps of: picking new branches of the selected manually-planted taxus chinensis var mairei with the age of more than 3 years from June to August annually, wherein the lengths of the picked branches range from 5cm to 8cm; smashing the picked branches to 8-10mm, and then drying the smashed branches for 20 minutes to 1 hour till the water content of the smashed branches reach 9% to 11%, wherein the temperature of drying gas flow ranges from 200 DEG C to 250 DEG C, and the gas flow rate ranges from 6000m3/h to 11000m3/h; and packaging the dried branches on an automatic packaging machine to obtain the aluminium-foil-inner-packaged taxus chinensis var mairei Chinese herbal material. The taxus chinensis var mairei Chinese herbal material obtained by the processing method can be taken as medicinal slices as well as raw materials for processing medicinal liquor, and can be taken orally to treat tumors and be externally applied to treat skin cancer.
Description
Technical field
The present invention relates to a kind of Taxus mairei Chinese crude drug and concocting method and application, belong to the Chinese medicine processing technical field.
Background technology
Ramulus et folium taxi cuspidatae is the general name of taxaceae Chinese yew genus plants, and there are 5 kinds of Ramulus et folium taxi cuspidatae, Taxus mairei, T. yunnanensis, Xizang Taxus chinensis, Chinese Ramulus et folium taxi cuspidatae in China.Ramulus et folium taxi cuspidatae is used as medical material, aspect the diseases such as treatment, adjuvant therapy of tumors, diabetes, nephropathy special efficacy is being arranged.Record " Taxus mairei " leaf is used as medicine in Wu Xiuren chief editor " Chinese medicinal plants short course ", and heat-clearing and toxic substances removing is controlled throat moth; Seed is used as medicine, and food stagnation is controlled in anthelmintic, ascariasis.Record China seed with Chinese yew genus plants among the people, branch and leaf are made diuresis and anthelmintic in Xiao Peigen chief editor " newly organized Chinese medicinal herbal ", and its branch, the leaf four seasons all can pluck.Record " Taxus mairei " seed in " national Chinese herbal medicine compilation " and be used as medicine, anthelmintic cures mainly food stagnation, ascariasis, and consumption seed 9～18 g make popular, are decocted in water for oral dose.Wu Tianlong chief editor's " plant resources is learned with nourishing healthy " but in put down in writing hyoscine in the taxaceae Ramulus et folium taxi cuspidatae, Taxus mairei (Resina Draconis), T. yunnanensis and Amentotaxus argotaenia (Hance) Pilger etc. are arranged.Record " Ramulus et folium taxi cuspidatae " dry branch and leaf are used as medicine in chief editors' such as chief editors' such as chief editors' such as " modern Chinese medicine voluminous dictionary ", Zhourong's Chinese " plant chemotaxonomy ", Zhao Zhongzhen " contemporary medicinal plants allusion quotation ", Cheng Jianhua the ancient books and records such as " anticancer vegetable drug and proved recipes thereof " has the effect of stimulating the menstrual flow with diuresis, cures mainly diseases such as nephritis edema, dysuria, diabetes, various tumor and leukemia.
The paclitaxel that extracts in the Ramulus et folium taxi cuspidatae is described as one of " over 20 years the most effectively cancer therapy drug ", and curative effect is certain, and is safe in utilization.Extensive approval and clinical effectiveness have preferably also been obtained at present with Ramulus et folium taxi cuspidatae Extract 10-deacetylate-Ba Kading III semisynthetic docetaxel.The traditional Chinese medical science thinks that Ramulus et folium taxi cuspidatae has the effect of supplementing QI and nourishing YIN, enriching blood and promoting secretion of body fluid, detoxicating and fighting cancer.The Taxus mairei of Donggang City, Wuxi City, Jiangsu Province town's artificial growth is one of kind of Chinese Ramulus et folium taxi cuspidatae, distribute extensively in China, main product in Fujian, ground such as Zhejiang, Jiangxi, Hunan, Sichuan, Yunnan; Jiangsu wuxi has the large tracts of land artificial growth.
The processing procedure of Chinese medicine is the pharmaceutical technology under Chinese medical theory instructs, and for the concocted technology of Chinese medicine, still is in the tradition stage at present, and it concocts processing mainly is the cutting process, so that allotment helps the fried of effective ingredient.In Chinese Pharmacopoeia of the prior art and the various places concocted specification, Ramulus et folium taxi cuspidatae Chinese crude drug concocting method is not recorded.In addition, the Chinese patent of Shanghai Kangqiao Medicinal Materials Electuary Co., Ltd. (CN10141828), its concocting process is selection, humidification is softening, section, drying, packing; But the concocting method that this patent is cut into slices after because of first humidification can be to the anticancer effective component bearing taxanes paclitaxel in the Taxus mairei; 10-deacetylate crust card fourth III; 10-deacetylate paclitaxel; 7-xylose-10-deacetylate paclitaxel, Cephalomannine cause degraded and the loss effective ingredient.
Summary of the invention
Technical problem to be solved by this invention is to overcome the weak point of above-mentioned prior art; Characteristic in conjunction with artificial planted south yew; The new processing procedure of research design Taxus mairei Chinese crude drug; Make the Taxus mairei medical material that obtains obtaining through concocting method of the present invention can be used as decoction pieces, the raw material of infusion medicated wine.Be used to take orally treatment tumor and external application for curing skin carcinoma.
In order to realize technical purpose of the present invention, technical scheme of the present invention is following.
One, a kind of Taxus mairei Chinese crude drug, it gets through following processing procedure preparation:
1) selection of medical material and harvesting: select the Taxus mairei of the artificial growth of the age of tree more than life in 3 years, pluck its newborn branch annual June to August, plucking branch length is 5-8 centimetre;
2) rapid draing: after the branch of plucking was crushed to the 8-10 millimeter, dry air temperature 200-250 ℃, gas flow rate 6000 was to 11000m
3/ h dry 20 minutes to 1 hour, is dried to its water content 9%-11%;
3) packing: on automatic packaging machine, be packaged into and meet aluminium foil fractional pack Taxus mairei Chinese crude drug.
Wherein, the breaking method described step 2) is that the Taxus mairei branch is pulverized with beater grinder.
Described step 2) drying means in is dry with strengthening airflow dryer.
Two, the processing procedure of Taxus mairei Chinese crude drug according to the invention, it comprises the steps:
1) selection of medical material and harvesting: select the Taxus mairei of the artificial growth of the age of tree more than life in 3 years, pluck its newborn branch annual June to August, plucking branch length is 5-8 centimetre;
2) rapid draing: after the branch of plucking was crushed to the 8-10 millimeter, dry air temperature 200-250 ℃, gas flow rate 6000 was to 11000m
3/ h dry 20 minutes to 1 hour, is dried to its water content 9%-11%;
3) packing: on automatic packaging machine, be packaged into clad aluminum foil fractional pack Taxus mairei Chinese crude drug.
Wherein, the breaking method described step 2) is that the Taxus mairei branch is pulverized with beater grinder.
Described step 2) drying means in is dry with strengthening airflow dryer.
Three, the application of south yew decoction pieces according to the invention in preparation treatment antitumor oral medicine.
Four, the application of south yew decoction pieces according to the invention in the anti-skin carcinoma medicament of preparation treatment external application.
Five, the application of south yew decoction pieces according to the invention in preparation medicated wine.
Beneficial effect of the present invention is:
(1) the described Taxus mairei age of tree of patent of the present invention more than life in 3 years for guaranteeing that enough biology harvesting amounts do not influence the normal growth of Ramulus et folium taxi cuspidatae trees; Plucking time is the trophophase of newborn branch during 6-8 month; The harvesting amount is big, and newborn branch is easy to differentiate.Choosing newborn branch mainly is newborn branch taxanesization of this time period and thing 10-deacetylate crust card fourth III, 10-deacetylate paclitaxel, and 7-xylose-10-deacetylate paclitaxel, the Cephalomannine total content is the highest, greater than 25/10000ths.And the wax fat layer of newborn Ramulus et folium taxi cuspidatae branch does not also form.Help the medical material as decoction pieces and infusion medicated wine, its total extractives content is higher than the old branch of plucking with the time about 9%.
(2) beater grinder mentioned of the present invention size that Ramulus et folium taxi cuspidatae is crushed to the 8-10 millimeter is in order to guarantee that Ramulus et folium taxi cuspidatae can realize in 2 hours that in strengthening airflow dryer rapid draing to water content is less than percent 11%; Wherein quick-drying purpose is in order to guarantee that bearing taxanes is not degraded in the Ramulus et folium taxi cuspidatae, and through the experiment contrast: the bearing taxanes total amount of the branch and leaf of flash baking remains unchanged basically.If long bearing taxanes total amount will reduce about 60% to 70% drying time.
(3) Taxus mairei Chinese crude drug of the present invention and processing procedure thereof are easier with respect to prior art; Saved the manufacturing cost of Chinese crude drug; And on the basis of simple process, guaranteed the drug effect and the bioavailability of decoction pieces to greatest extent, its range of application and effect are better more greatly.
The specific embodiment
Embodiment 1
20100607 batches.
The harvesting of medical material: on June 7th, 2010; People work post Taxus mairei (Wuxi City, Jiangsu Province Donggang City town Ramulus et folium taxi cuspidatae planting base) the newborn branch of manual picking length more than 5-8 centimetre 3 ages; Choose 360 kilograms in the Ramulus et folium taxi cuspidatae branch of healthy no dead leaf, detect its water content 66.5%.
Pulverize: 340 kilograms in 360 kilograms of branch and leaf that will obtain are fed in the beater disintegrating machine, and control is pulverized width at the 8-10 millimeter.Obtain 337 kilograms of Ramulus et folium taxi cuspidatae that crush.Yield 99.1%.
Dry: 337 kilograms of Ramulus et folium taxi cuspidatae that will crush are sent into GFF-350 strengthening airflow dryer group (buying from Changzhou the second drying equipment company limited) through conveyer belt, temperature 250 degree, gas flow rate 11000 m
3/ h, discharging time 20 minutes.Discharging opening obtains 110 kilograms of materials, moisture 9.5%, yield 88.9%.
Packing: use the Aluminium Foil Package pack on automatic packaging machine, the Ramulus et folium taxi cuspidatae medical material to be distributed into the 10g/ bag.Pack 10200 bags altogether, yield rate: 92.7%.
Embodiment 2
20100608 batches.
The harvesting of medical material: on June 8th, 2010; People work post Taxus mairei (Wuxi City, Jiangsu Province Donggang City town Ramulus et folium taxi cuspidatae planting base) the newborn branch of manual picking length more than 5-8 centimetre 3 ages, the Ramulus et folium taxi cuspidatae branch of choosing healthy no dead leaf detects water content 66.9% for 620 kilograms.
Pulverize: 600 kilograms in 620 kilograms of branch and leaf that will obtain are fed in the beater disintegrating machine, and control is pulverized width at the 8-10 millimeter.Obtain 590 kilograms of Ramulus et folium taxi cuspidatae that crush.Yield 98.3%.
Dry: 590 kilograms of Ramulus et folium taxi cuspidatae that will crush are sent into GFF-350 strengthening airflow dryer group through conveyer belt, temperature 200 degree, gas flow rate 6000 m
3/ h, discharging time 1 hour.Discharging opening obtains 192 kilograms, moisture 9.7%, yield 88.9%.
Packing: use In Aluminium Foil Packing, on automatic packaging machine, 192 kilograms of Ramulus et folium taxi cuspidatae medical materials are distributed into the 10g/ bag.Pack 18432 bags altogether, yield rate: 96%.
Embodiment 3
Present embodiment is the content contrast experiment.
One, 20100607y criticizes.
The harvesting of medical material: on June 7th, 2010, the Ramulus et folium taxi cuspidatae branch that the aging branch of the people work post Taxus mairei (Wuxi City, Jiangsu Province Donggang City town Ramulus et folium taxi cuspidatae planting base) of manual picking length more than 5-8 centimetre 3 ages is chosen healthy no dead leaf detects water content 60.9% for 20 kilograms.
Pulverize: 20 kilograms of branch and leaf that will obtain are fed in the beater disintegrating machine, and control is pulverized width at the 8-10 millimeter.Obtain 19 kilograms of Ramulus et folium taxi cuspidatae that crush.Yield 95%.
Dry: 19 kilograms of Ramulus et folium taxi cuspidatae that will crush are sent into GFF-350 strengthening airflow dryer group through conveyer belt, temperature 250 degree, gas flow rate 11000 m
3/ h, discharging time 20 minutes.Discharging opening obtains 7.3 kilograms, moisture 10.7%, yield 88.1%.
Packing: use In Aluminium Foil Packing, on automatic packaging machine, 7.3 kilograms of Ramulus et folium taxi cuspidatae medical materials are distributed into the 100g/ bag.72 bags.
Two, 20100608y criticizes.
The harvesting of medical material: on June 8th, 2010, the Ramulus et folium taxi cuspidatae branch that the aging branch of the people work post Taxus mairei (Wuxi City, Jiangsu Province Donggang City town Ramulus et folium taxi cuspidatae planting base) of manual picking length more than 5-8 centimetre 3 ages is chosen healthy no dead leaf detects water content 60.9% for 20 kilograms.
Pulverize: 20 kilograms of branch and leaf that will obtain are fed in the beater disintegrating machine, and control is pulverized width at the 8-10 millimeter.Obtain 19 kilograms of Ramulus et folium taxi cuspidatae that crush.Yield 95%.
Dry: 19 kilograms of Ramulus et folium taxi cuspidatae that will crush are sent into GFF-350 strengthening airflow dryer group through conveyer belt, temperature 250 degree, gas flow rate 11000 m
3/ h, discharging time 20 minutes.Discharging opening obtains 7.3 kilograms, moisture 10.7%, yield 88.1%.
Packing: use In Aluminium Foil Packing, on automatic packaging machine, 7.5 kilograms of Ramulus et folium taxi cuspidatae medical materials are distributed into the 100g/ bag.74 bags.
Embodiment 4
With 20100607 batches with 20100608 batches in untreated remaining 20 kilograms of fresh branch and leaf of obtaining prepare the dried branch and leaf 20100607x-contrast of Ramulus et folium taxi cuspidatae batches 5.7 kilograms according to 1 describing method of Chinese patent CN10141828 description page 2 embodiment, 20100608x contrast batches 5.9 kilograms.Get 20100607,20100608 batches respectively, with 20100607x contrast batch, 20100608x contrast batch, 20100607y contrast batch, 20100608y contrast crowd contrast experiment.
Content detecting method sample thief 10g, ultrasonic in 100 mL methanol, (power 300W, frequency 50kHz), and 25 ~ 30 ℃ is to stir after 30 minutes under the room temperature, repeats to extract 3 times with methanol, the merging methanol extract liquid is dissolved in 10mL methanol after concentrating and doing.Pass through the bearing taxanes 10-deacetylate paclitaxel (10-DAT) in the external standard method Detection and Extraction thing with high performance liquid chromatograph; 10-deacetylate crust card fourth III (10-DAB); 10-deacetylate 7-xylose paclitaxel (7-XYT) content, and three's total content.
Wherein the condition of HPLC is:
ZORBAX Extend-C18 HPLC post 4.6 * 250mm
; Sample size 5 μ L; Mobile phase: acetonitrile: water=31:69; Column temperature=25 ℃, flow velocity=1.0mL/min.
The extract content detection method:
Adopt hot dipping: get the about 4g of test sample, the accurate title, decide.Put in the conical flask of 250 mL, precision adds dehydrated alcohol 50mL, and close plug is claimed decide weight, leave standstill 1 hour after, the connection reflux condensing tube is heated to boiling, and keeps little and boiled 1 hour.Put cold after, take off conical flask, close plug claims to decide weight again; Supply the weight that subtracts mistake with dehydrated alcohol, shake up, filter with dry filter; Precision is measured filtrating 25mL, puts in the evaporating dish that is dried to constant weight, behind evaporate to dryness in the water-bath; In 105 ℃ of dryings 3 hours, put in the exsiccator cooling 30 minutes, accurately rapidly claim to decide weight.Calculate the content (%) of water-soluble extractives in the test sample with dry product.
Conclusion: the Taxus mairei medical material that the processing procedure that batch relatively can find out according to the present invention to be selected for use with other two batches contrasts obtains all is higher than the Ramulus et folium taxi cuspidatae medical material of the existing technology report process of preparing Chinese medicine at extract content and bearing taxanes total content.
Embodiment 5
Following examples are replenishing of the foregoing description.
20110711 batches.
The harvesting of medical material: on July 11st, 2011; People work post Taxus mairei (Wuxi City, Jiangsu Province Donggang City town Ramulus et folium taxi cuspidatae planting base) the newborn branch of manual picking length more than 5-8 centimetre 3 ages; Choose 360 kilograms in the Ramulus et folium taxi cuspidatae branch of healthy no dead leaf, detect its water content 67.1%.
Pulverize: 340 kilograms of branch and leaf that will obtain are fed in the beater disintegrating machine, and control is pulverized width at the 8-10 millimeter.Obtain 337 kilograms of Ramulus et folium taxi cuspidatae that crush.Yield 98.9%.
Dry: 337 kilograms of Ramulus et folium taxi cuspidatae that will crush are sent into GFF-350 strengthening airflow dryer group through conveyer belt, temperature 220 degree, gas flow rate 8000 m
3/ h, discharging time 60 minutes.Discharging opening obtains 112 kilograms of materials, moisture 9%, yield 89.1%.
Packing: use the Aluminium Foil Package pack on automatic packaging machine, the Ramulus et folium taxi cuspidatae medical material to be distributed into the 10g/ bag.Pack 10000 bags altogether, yield rate: 92.6%.
Embodiment 6
20110809 batches.
The harvesting of medical material: on August 9th, 2011; People work post Taxus mairei (Wuxi City, Jiangsu Province Donggang City town Ramulus et folium taxi cuspidatae planting base) the newborn branch of manual picking length more than 5-8 centimetre 3 ages; Choose 360 kilograms in the Ramulus et folium taxi cuspidatae branch of healthy no dead leaf, detect its water content 67.0%.
Pulverize: 360 kilograms of branch and leaf that will obtain are to beater disintegrating machine, and control is pulverized width at the 8-10 millimeter.Obtain 337 kilograms of Ramulus et folium taxi cuspidatae that crush.Yield 99.1%.
Dry: 337 kilograms of Ramulus et folium taxi cuspidatae that will crush are sent into GFF-350 strengthening airflow dryer group through conveyer belt, temperature 240 degree, gas flow rate 7000 m
3/ h, discharging time 40 minutes.Discharging opening obtains 115 kilograms of materials, moisture 11%, yield 89.7%.
Packing: use the Aluminium Foil Package pack on automatic packaging machine, the Ramulus et folium taxi cuspidatae medical material to be distributed into the 10g/ bag.Pack 10500 bags altogether, yield rate: 93.1%.
Embodiment 7
Present embodiment is explained the application of south yew decoction pieces of the present invention in preparation treatment antitumor oral medicine.
Press down the tumor experiment in the body: 80 of mices, be divided into 2 groups at random, inoculation s180 oncocyte with.Every group of concrete operations are following: transfer oncocyte to 1 * 10
6Individual/mL, subcutaneous vaccination 0.2mL/ only is divided into 4 groups next day at random, 10 every group, weighs.After extracting 3 times with the every gram of Ramulus et folium taxi cuspidatae Chinese crude drug of 20100608 batches of preparations of sample continuously with 5mL water, give continuous 14 days of mouse feeding, one group of blank control group wherein, 1g/ days groups of Ramulus et folium taxi cuspidatae medical material, 2g/ days groups, 5g/ days groups with the aqueous solution of gained.Respectively at l, 3,5,7,9,11,13 days totally 7 times.Drug withdrawal is weighed next day, puts to death mice and peels off the subcutaneous tumors piece, claims that tumor is heavy, calculates tumour inhibiting rate (seeing table 1).
In like manner, the application of south yew decoction pieces of the present invention in the anti-skin carcinoma medicament of preparation treatment external application set up too.
Embodiment 8
Present embodiment is explained the application of south yew decoction pieces of the present invention in preparation medicated wine.
Press down the tumor experiment in the body: 80 of mices are divided into 2 groups, inoculation s180 oncocyte at random.Every group of concrete operations are following: transfer oncocyte to 1 * 10
6Individual/mL, subcutaneous vaccination 0.2mL/ only is divided into 4 groups next day at random, 10 every group, weighs.Ramulus et folium taxi cuspidatae Chinese crude drug 100g with 20100608 batches of preparations of sample must filtrate with 30 days after-filtration of 2L 65% alcohol solution dipping; Give continuous 14 days of mouse feeding with the soak of gained; One group of blank control group feeding 2mL 65% alcoholic solution/sky wherein; 0.5mL/ days groups of Ramulus et folium taxi cuspidatae medical material, 1mL/ days groups, 2mL/ days groups.Respectively at l, 3,5,7,9,11,13 days totally 7 times.Drug withdrawal is weighed next day, puts to death mice and peels off the subcutaneous tumors piece, claims that tumor is heavy, calculates tumour inhibiting rate (seeing table 2).
Claims (9)
1. Taxus mairei Chinese crude drug, it gets through following processing procedure preparation:
1) selection of medical material and harvesting: select the Taxus mairei of the artificial growth of the age of tree more than life in 3 years, pluck its newborn branch annual June to August, plucking branch length is 5-8 centimetre;
2) rapid draing: after the branch of plucking is crushed to the 8-10 millimeter, baking temperature 200-250 ℃, dry 20 minutes to 2 hours, be dried to its water content 9%-11%;
3) packing: on automatic packaging machine, be packaged into and meet aluminium foil fractional pack Taxus mairei Chinese crude drug.
2. Taxus mairei Chinese crude drug according to claim 1 is characterized in that step 2) described breaking method is to pulverize with beater grinder.
3. Taxus mairei Chinese crude drug according to claim 1 is characterized in that step 2) described drying means is dry with strengthening airflow dryer.
4. the processing procedure of the said Taxus mairei Chinese crude drug of claim 1, it comprises the steps:
1) selection of medical material and harvesting: select the Taxus mairei of the artificial growth of the age of tree more than life in 3 years, pluck its newborn branch annual June to August, plucking branch length is 5-8 centimetre;
2) rapid draing: after the branch of plucking is crushed to the 8-10 millimeter, baking temperature 200-250 ℃, dry 20 minutes to 2 hours, be dried to its water content 9%-11%;
3) packing: on automatic packaging machine, be packaged into and meet aluminium foil fractional pack Taxus mairei Chinese crude drug.
5. the processing procedure of Taxus mairei Chinese crude drug according to claim 4 is characterized in that step 2) described breaking method is to pulverize with beater grinder.
6. the processing procedure of Taxus mairei Chinese crude drug according to claim 4 is characterized in that step 2) described drying means is dry with strengthening airflow dryer.
7. the application of the described Taxus mairei Chinese crude drug of claim 1 in preparation treatment antitumor oral medicine.
8. the application of the described Taxus mairei Chinese crude drug of claim 1 in the anti-skin carcinoma medicament of preparation treatment external application.
9. the application of the described Taxus mairei Chinese crude drug of claim 1 in preparation medicated wine.
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Cited By (6)
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| CN103099843A (en) * | 2012-12-17 | 2013-05-15 | 潘凌烊 | Health-care product capsule for treating cancers and preparation method thereof |
| CN103202865A (en) * | 2013-04-28 | 2013-07-17 | 朱乃根 | Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof |
| CN104352537A (en) * | 2014-10-20 | 2015-02-18 | 哈尔滨红豆杉科技开发有限责任公司 | Preparation method of yew traditional Chinese medicine decoction pieces |
| CN113332319A (en) * | 2021-03-31 | 2021-09-03 | 段世锋 | Method for processing medicinal artificial breeding and planting Chinese yew of Mandiya variety |
| CN115184493A (en) * | 2022-07-06 | 2022-10-14 | 株洲市食品药品检验所 | Fingerprint detection method for active ingredients in taxus mairei medicinal material and traditional Chinese medicine decoction pieces thereof |
| CN115969890A (en) * | 2021-10-15 | 2023-04-18 | 重庆华奥药业股份有限公司 | Processing technology of taxus chinensis decoction pieces |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099843A (en) * | 2012-12-17 | 2013-05-15 | 潘凌烊 | Health-care product capsule for treating cancers and preparation method thereof |
| CN103202865A (en) * | 2013-04-28 | 2013-07-17 | 朱乃根 | Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof |
| CN104352537A (en) * | 2014-10-20 | 2015-02-18 | 哈尔滨红豆杉科技开发有限责任公司 | Preparation method of yew traditional Chinese medicine decoction pieces |
| CN104352537B (en) * | 2014-10-20 | 2017-09-29 | 哈尔滨红豆杉科技开发有限责任公司 | A kind of preparation method of the Japanese yew prepared slices of Chinese crude drugs |
| CN113332319A (en) * | 2021-03-31 | 2021-09-03 | 段世锋 | Method for processing medicinal artificial breeding and planting Chinese yew of Mandiya variety |
| CN115969890A (en) * | 2021-10-15 | 2023-04-18 | 重庆华奥药业股份有限公司 | Processing technology of taxus chinensis decoction pieces |
| CN115184493A (en) * | 2022-07-06 | 2022-10-14 | 株洲市食品药品检验所 | Fingerprint detection method for active ingredients in taxus mairei medicinal material and traditional Chinese medicine decoction pieces thereof |
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Application publication date: 20120822 |