CN102258094B - Tea drink containing natural plants or natural plant extracts, and preparation method and application thereof - Google Patents
Tea drink containing natural plants or natural plant extracts, and preparation method and application thereof Download PDFInfo
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to tea drink containing natural plants or natural plant extracts, and a preparation method and application thereof, and belongs to the technical field of tea drink. The tea drink containing the natural plants or the natural plant extracts is characterized by consisting the following materials in percentage by weight: 50 to 80 percent of taxus media needle, 10 to 20 percent of whole mimosa pudica and 10 to 30 percent of green tea, or 45 to 70 percent of taxus media needle, 10 to 20 percent of extractive of whole mimosa pudica and 20 to 35 percent of extractive of green tea. The tea drink is natural, fresh and healthy, has a simple preparation method, can leach active ingredients quickly and is convenient to carry and drink. The product has the effects of clearing heat and releasing toxin, resisting bacteria and sterilizing, removing heat and toxin, relieving exterior syndrome and dispelling wind, promoting blood circulation and removing blood stasis, eliminating bacteria and diminishing inflammation, and relieving itching and removing tinea, and can effectively prevent and treat psoriasis, eczema and pruritus.
Description
Technical field
The invention belongs to tea-drinking article technical field, be specially a kind of tea-drinking article that contain natural plants or natural plant extracts.
Background technology
Modern society is fast changing, the violent and superior material life condition of the increase of Along with people's operating pressure, social competition has caused many moderns to be in sub-health state and to become sub-health population, makes the demand also day by day increase of modern society to health products and tea-drinking article.
Along with growth in the living standard; People no longer only stop on the desired level of general tea in bag, instant tea the demand of solid beverage; And more and more many people be more prone to consume nature, health, healthy nutritive value high the solid tea beverage; Under this background and form, the instant tea and the tea in bag of exploitation instant-drink are very popular.The tea-drinking article that production has health care and therapeutic action will have the very big market space.
Instant tea and the tea in bag sold in the market have certain effect of quenching one's thirst of relieving summer heat more.Some health protection tea drink; Added a variety of rare medicinal herbs and be used for health care, prevent or treat certain disease, but the tea-drinking article that contain Taxus x media needle or its extract are used for prevention and treat fungal infection and psoriatic technical method does not see that report is arranged as the genseng.
Taxus x media is a shrub kind unique in the Chinese yew; Evergreen, fruit ruby of its four seasons, tree-like attractive in appearance, branch type grace, dark green, the anti-pruning of color and luster, adaptability are strong; Can under multiple weather and edaphic condition, grow; Becoming multiple artistic shapes such as circle, umbrella shape, tower through the manual work pruning and extensively plant, is that greening that is extremely precious, that be loved by the people is viewed and admired and the indoor pot seeds.
Taxol is from bark of Ramulus et folium taxi cuspidatae and rhizome, to extract a kind of taxane diterpene-kind compound that obtains; It is cancer therapy drug with its particular mechanism; Can effectively treat advanced breast cancer, oophoroma and other cancers; And do not have tangible bad reaction, be human following 20 years the most effectively one of cancer therapy drugs.Taxus x media plant each several part all contains Diterpenes anticancer effective component such as taxol, Cephalomannine, 10-deacetylation Bakating III, and only the content of taxol just reaches 0.03% in the branches and leaves.The content of taxol of 70～80 years natural bark of Ramulus et folium taxi cuspidatae of content of taxol and growth is suitable in the Taxus x media leaf of life in 4～5 years and the branch.Is the taxol that raw material extracts with the Taxus x media, has fabulous effect such as anticancer, antiviral.It is a desirable natural drug.
Sensitive plant is the herb of pulse family Mimosa plant sensitive plant, has another name called to know shy grass, coy grass etc.Mainly be distributed in hillside jungle, wetland, the roadside on ground such as China East China, south China, southwest.Have reducing fever and causing diuresis, purging intense heat and detonicating, degerming anti-inflammatory, effect such as antipruritic, the clinical treatments that are used for diseases such as eczema, herpes zoster, pruitus more.
Mainly contain compositions such as flavonoids, alkaloids in the sensitive plant, research shows, the active component in the sensitive plant have anti peroxidation of lipid, anti-ageing, remove many-sided effect such as free radical, anti-inflammation, antiviral, raise immunity.
Mainly contain catechin compositions such as Tea Polyphenols in the green tea, Tea Polyphenols has the effect of very strong anti-oxidant, anti-ageing, anti peroxidation of lipid, removing free radical, antibiotic aspect such as anticorrosion.
Summary of the invention
To the problems referred to above that exist in the prior art; The objective of the invention is to design provide a kind of tea-drinking article that contain natural plants or natural plant extracts and its production and use technical scheme; These tea-drinking article are natural, fresh, healthy; The preparation method is simple, can leach active ingredient very soon, carry and drink conveniently; Have that clearing heat and detoxicating, antibiotic and sterilizing, clearing heat and cooling blood, the fire of dispelling relieve internal heat, inducing diaphoresis to dispel wind, promoting blood circulation and removing blood stasis, the effect of degerming anti-inflammatory, the antipruritic tinea of dispelling has significant curative effect to diseases such as psoriasis, eczema and pruituses.Long-term efficacy is obvious, and is stable, cures the back and is difficult for recurrence.
Described a kind of tea-drinking article that contain natural plants is characterized in that being made up of the following material of weight percentage: 50%～80% Taxus x media needle, 10%～20% sensitive plant herb, 10%～30% green tea.
Described a kind of tea-drinking article that contain natural plants, the content that it is characterized in that the Taxus x media needle is 55%～75%, preferred 60%～70%; The content of sensitive plant herb is 12%～18%, preferred 15%～16%; The content of green tea is 15%～25%, preferred 18%～20%.
Described a kind of tea-drinking article that contain natural plant extracts is characterized in that being made up of the following material of weight percentage: Taxus x media needle extract 45%～70%, sensitive plant herb extract 10%～20%, green tea extract 20%～35%.
Described a kind of tea-drinking article that contain natural plant extracts, it is characterized in that: the content of Taxus x media needle extract is 50%～65%, preferred 55%～600%; The content of sensitive plant herb extract is 12%～18%, 15%～16%; The content of green tea extract is 22%～30%, preferred 25%～28%.
Described a kind of preparation method who contains the tea-drinking article of natural plant extracts is characterized in that:
Said Taxus x media needle extract adopts following method preparation; May further comprise the steps: the needle of the Taxus x media of drying is put in the container of broken extractor, added 50%～100% ethanol, starting switch; Rotating speed with 8000 r/min～15000 r/min carries out the broken extraction of room temperature texture 1～3 time; Raw material is broken into can passes through 20～40 purpose granularities, if Taxus x media dry weight be 1 kg then the hydrous ethanol consumption be 5～9 liters, each extraction time is 1～3 minute; With the extract suction filtration; Discard filter residue, the extract that merging obtains is at 50 ℃～80 ℃, and vacuum is to adopt Reduced Pressure Concentration Device to carry out flash concentration under the 0.095 Mpa condition; Regulate the feed liquor speed of solution to be concentrated; Flow with 200～350 mLmin-1 is concentrated into 1/4 ~ 1/8 of original volume repeatedly, then concentrate is proceeded vacuum drying and becomes dry powder, with obtaining Taxus x media extract dry powder behind the mortar porphyrize;
Said sensitive plant preparation method of extract; May further comprise the steps: the sensitive plant herb of drying is put in the container of broken extractor, added 50%～80% ethanol, starting switch; Rotating speed with 8000 r/min～15000 r/min carries out the broken extraction of room temperature texture 2～3 times; Raw material is broken into can passes through 20～40 purpose granularities, if sensitive plant dry weight be 1 kg then the hydrous ethanol consumption be 6～12 liters, each extraction time is 2～5 minutes; With the extract suction filtration; Discard filter residue, the extract that merging obtains is at 50 ℃～70 ℃, and vacuum is to adopt Reduced Pressure Concentration Device to carry out flash concentration under the 0.095 Mpa condition; Regulate the feed liquor speed of solution to be concentrated; Flow with 150～300 mLmin-1 is concentrated into 1/5 ~ 1/10 of original volume repeatedly, then concentrate is proceeded vacuum drying and becomes dry powder, with obtaining sensitive plant extract dry powder behind the mortar porphyrize;
The preparation method of said green-tea extract; May further comprise the steps: the green tea of drying is put in the container of broken extractor, added 50%～80% ethanol, starting switch; Rotating speed with 8000 r/min～15000 r/min carries out the broken extraction of room temperature texture 1～2 time; Raw material is broken into can passes through 20～60 purpose granularities, if green tea dry weight be 1 kg then the hydrous ethanol consumption be 7～14 liters, each extraction time is 1～3 minute; With the extract suction filtration; Discard filter residue, the extract that merging obtains is at 50 ℃～70 ℃, and vacuum is to adopt Reduced Pressure Concentration Device to carry out flash concentration under the 0.095 Mpa condition; Regulate the feed liquor speed of solution to be concentrated; Flow with 150～300 mLmin-1 is concentrated into 1/6 ~ 1/12 repeatedly, then concentrate is proceeded vacuum drying and becomes dry powder, with obtaining green-tea extract dry powder behind the mortar porphyrize.
Described a kind of preparation method who contains the tea-drinking article of natural plant extracts is characterized in that in the said Taxus x media needle preparation method of extract: concentration of ethanol is 60%～90% during broken the extraction, preferred 70%～78%; Rotating speed is 10000 r/min～12000 r/min; The temperature of flash concentration is 55 ℃～75 ℃, preferred 62 ℃～72 ℃; Feed liquor speed 250～320 mLmin of solution to be concentrated
-1, preferred 280～300 mLmin
-1Concentrate is concentrated into 1/5 ~ 1/7 of original volume.
Described a kind of preparation method who contains the tea-drinking article of natural plant extracts is characterized in that in the said sensitive plant preparation method of extract: concentration of ethanol is 60%～70% during broken the extraction, preferred 62%～78%; Rotating speed is 10000 r/min～12000 r/min; The temperature of flash concentration is 55 ℃～65 ℃, preferred 58 ℃～62 ℃; Feed liquor speed 200～280 mLmin of solution to be concentrated
-1, preferred 220～250 mLmin
-1Concentrate is concentrated into 1/6 ~ 1/9 of original volume.
Described a kind of preparation method who contains the tea-drinking article of natural plant extracts is characterized in that among the preparation method of said green-tea extract: concentration of ethanol is 60%～70% during broken the extraction, preferred 62%～78%; Rotating speed is 10000 r/min～12000 r/min; The temperature of flash concentration is 55 ℃～65 ℃, preferred 58 ℃～62 ℃; Feed liquor speed 200～280 mLmin of solution to be concentrated
-1, preferred 220～250 mLmin
-1Concentrate is concentrated into 1/8 ~ 1/10 of original volume.
The described a kind of application of tea-drinking article in preparation control skin eczema, pruitus, psoriasic preparation that contains natural plants.
The described a kind of application of tea-drinking article in preparation control skin eczema, pruitus, psoriasic preparation that contains natural plant extracts.
Above-mentioned a kind of tea-drinking article that contain natural plants or natural plant extracts, natural, fresh, healthy, the preparation method is simple, can leach active ingredient very soon, carry and drink conveniently, has following beneficial effect:
1, the product of this invention can effectively be cured diseases such as psoriasis and eczema, pruitus, also is used for anti-cancer and cancer-preventing, and does not recur, and does not have other side effects, can adapt to all kinds of crowds and use, and is easy to utilize.
2, this product compatibility is reasonable, and complementation is remarkable, and is with low cost, and preparation technology is simple, and is easy to use and carry, evident in efficacy, short treating period, and per 30 days is a course of treatment, and two course cure rates reach more than 70%, and total effective rate can reach more than 90%.
3, Taxus x media is as ornamental plant and natural anti-cancer drugs, and its root mainly is used for extracting taxol as anti-cancer medicament raw material, and the whole plant of life in 3～5 years is used for doing the potted landscape of viewing and admiring usefulness, need prune the ability moulding and afforest the potted landscape of viewing and admiring usefulness.The a large amount of scrappy needle that prunes away is as leftover bits, and utilization rate is very low.And use it for the raw material of making the tea-drinking article, and through comparing test, find that content of effective and result of treatment are all unaffected with normal needle, therefore improved the resource utilization of Taxus x media greatly.
What 4, among the present invention Taxus x media needle, sensitive plant, green tea are adopted is that broken extraction method is extracted; Promptly at room temperature raw material and solvent are put in the extractor; Utilize the cutter of rotation at a high speed that raw material crushing is trimmed to fine particle; Through the combination of high-speed stirred, vibration, mixing, infiltration, dipping, make the inner active ingredient of medicinal material in the extremely short time, be transferred in the solvent and reach the stripping balance, realize extracting purpose through filtering.When having realized pulverizing and leaching process, accomplishes this method for distilling; The broken extraction once only needs a few minutes, and leaching process need not heating simultaneously, the possibility of avoiding thermo-labile component to destroy; Has quick, complete, energy-efficient, easy and simple to handle, the more high advantage of operating efficiency of extraction.Adopting this method to extract can extract the most of functional component in the above natural plants fully, has improved functional component recovery rate and content.The extract that obtains adopts Reduced Pressure Concentration Device to carry out flash concentration.Use this device to concentrate to have the concentrate heating temperature low; Extremely lacked (several seconds) by the concentrated liquid heated time, effectively protect the thermal sensitivity composition not to be destroyed, solvent recovering yield is high; The instrument capacity is big; Do not receive by the restriction of concentrate volume size, concentrate that speed is fast, efficient is high, advantages such as simple to operate, easy to use, energy-conserving and environment-protective.
The percentage composition that relates in the present specification unless otherwise indicated all refers to weight percentage.
The specific embodiment
Combine embodiments of the invention and correlation test at present, the present invention is described further.
Embodiment 1
Tea in bag prescription 1: according to percentage by weight, the Taxus x media needle by 50%, 20% sensitive plant herb, 30% green tea fully mix, and each prescription sum is 100%.
Embodiment 2
Tea in bag prescription 2: according to percentage by weight, the Taxus x media needle by 80%, 10% sensitive plant herb, 10% green tea fully mix, and each prescription sum is 100%.
Embodiment 3
Tea in bag prescription 3: according to percentage by weight, the Taxus x media needle by 60%, 20% sensitive plant herb, 20% green tea fully mix, and each prescription sum is 100%.
Embodiment 4
Tea in bag prescription 4: according to percentage by weight, the Taxus x media needle by 70%, 15% sensitive plant herb, 15% green tea fully mix, and each prescription sum is 100%.
Embodiment 5
Instant tea prescription 1: according to percentage by weight, mix by Taxus x media needle extract 45%, sensitive plant herb extract 20%, green tea extract 35%, each prescription sum is 100%.
Embodiment 6
Instant tea prescription 2: according to percentage by weight, mix by Taxus x media needle extract 70%, sensitive plant herb extract 10%, green tea extract 20%, each prescription sum is 100%.
Embodiment 7
Instant tea prescription 3: according to percentage by weight, mix by Taxus x media needle extract 60%, sensitive plant herb extract 15%, green tea extract 25%, each prescription sum is 100%.
Embodiment 8
Instant tea prescription 4: according to percentage by weight, mix by Taxus x media needle extract 55%, sensitive plant herb extract 15%, green tea extract 30%, each prescription sum is 100%.
The prescription of tea in bag and processing technology: Taxus x media needle, sensitive plant herb, the green tea with drying is ground into meal with pulverizer respectively, crosses 20 mesh sieves respectively; According to percentage by weight, the Taxus x media needle by 50%～80%, 10%～20% sensitive plant herb, 10%～30% green tea fully mix, and each prescription sum is 100%; According to every bag of 5g, adopt automatic bag sealing machine envelope filter paper bag, process tea in bag.
The prescription of instant tea and processing technology: according to percentage by weight, mix by Taxus x media needle extract 45%～70%, sensitive plant herb extract 10%～20%, green tea extract 20%～35%, each prescription sum is 100%; According to every bag of 3g, adopt automatic bag sealing machine envelope polybag, process instant tea.
Instructions of taking and consumption: every day 2 times, each 1 bag, boiling water brews to be drunk, and every bag towards one glass of water of 500ml, twice of every day.Note dose, can not excess take.
Said Taxus x media needle extract adopts following method preparation; May further comprise the steps: the needle of the Taxus x media of drying is put in the container of broken extractor, added 50%～100% ethanol, starting switch; Rotating speed with 8000 r/min～15000 r/min carries out the broken extraction of room temperature texture 1～3 time; Raw material is broken into can passes through 20～40 purpose granularities, if Taxus x media dry weight be 1 kg then the hydrous ethanol consumption be 5～9 liters, each extraction time is 1～3 minute; With the extract suction filtration, discard filter residue, the extract that merging obtains is at 50 ℃～80 ℃, and vacuum is to adopt Reduced Pressure Concentration Device to carry out flash concentration under the 0.095 Mpa condition, regulates the feed liquor speed of solution to be concentrated, with 200～350 mLmin
-1Flow be concentrated into 1/4 ~ 1/8 of original volume repeatedly, then concentrate is proceeded vacuum drying and becomes dry powder, with obtaining Taxus x media extract dry powder behind the mortar porphyrize, the yield of extract reaches 10.2%～25.6%.
Said sensitive plant preparation method of extract; May further comprise the steps: the sensitive plant herb of drying is put in the container of broken extractor, added 50%～80% ethanol, starting switch; Rotating speed with 8000 r/min～15000 r/min carries out the broken extraction of room temperature texture 2～3 times; Raw material is broken into can passes through 20～40 purpose granularities, if sensitive plant dry weight be 1 kg then the hydrous ethanol consumption be 6～12 liters, each extraction time is 2～5 minutes; With the extract suction filtration, discard filter residue, the extract that merging obtains is at 50 ℃～70 ℃, and vacuum is to adopt Reduced Pressure Concentration Device to carry out flash concentration under the 0.095 Mpa condition, regulates the feed liquor speed of solution to be concentrated, with 150～300 mLmin
-1Flow be concentrated into 1/5 ~ 1/10 of original volume repeatedly, then concentrate is proceeded vacuum drying and becomes dry powder, with obtaining sensitive plant extract dry powder behind the mortar porphyrize, the yield of extract reaches 18.2%～26.9%.
The preparation method of said green-tea extract; May further comprise the steps: the green tea of drying is put in the container of broken extractor, added 50%～80% ethanol, starting switch; Rotating speed with 8000 r/min～15000 r/min carries out the broken extraction of room temperature texture 1～2 time; Raw material is broken into can passes through 20～60 purpose granularities, if green tea dry weight be 1 kg then the hydrous ethanol consumption be 7～14 liters, each extraction time is 1～3 minute; With the extract suction filtration, discard filter residue, the extract that merging obtains is at 50 ℃～70 ℃, and vacuum is to adopt Reduced Pressure Concentration Device to carry out flash concentration under the 0.095 Mpa condition, regulates the feed liquor speed of solution to be concentrated, with 150～300 mLmin
-1Flow be concentrated into 1/6 ~ 1/12 repeatedly, then concentrate is proceeded vacuum drying and becomes dry powder, with obtaining green-tea extract dry powder behind the mortar porphyrize, the yield of extract reaches 30.5%～45.2%.
The design and assembly voluntarily of described Reduced Pressure Concentration Device, broken extraction equipment can be by directly buying on the market.
Embodiment 9
Embodiment 10
Embodiment 11
Embodiment 12
Embodiment 13
Embodiment 14
For further specifying result of treatment of the present invention, its prevention effect is described through following test data and some experimental observation results.
1,3 kinds of content of effective are measured in Taxus x media needle and the extract thereof
(1) instrument and reagent
ACQUITY UPLC Ultra Performance Liquid Chromatography instrument system (U.S. Waters company), Waters Acquity UPLC
TM: Acquity BEH Shield RP
18Chromatographic column; Be equipped with binary solvent manager, automatic sampler, PDA PDAD, binary high-pressure pump; The MassLynxV4.1 chromatographic work station; Millipore Simplicity type Superpure water machine (U.S. Millipore company), AUTO SCIENCE solvent filtration apparatus, Extraction by Ultrasound device (Kunshan KQ-500B).
The dry needle of Taxus x media is pulverized through 40 ℃ of dryings, and it is subsequent use to cross 60 mesh sieves.Reference substance 10-deacetylation Bakating III, Cephalomannine, taxol purity are all greater than 98%.Acetonitrile is a chromatographically pure; Water is ultra-pure water.
(2) the preparation reference substance solution of reference substance solution and need testing solution: precision takes by weighing 10-deacetylation Bakating III reference substance 1.0 mg respectively; Cephalomannine reference substance 3.5 mg; Taxol reference substance 7.2 mg; Add methyl alcohol dissolving constant volume, the mass concentration of processing 10-deacetylation Bakating III Cephalomannine and taxol is respectively 0.04,0.035,0.072 mg mL
-1Reference substance solution, 4 ℃ of preservations of refrigerator are subsequent use.
Need testing solution: get 45 ℃ of Taxus x media needle powder and Taxus x media extract powder (crossing sieve No. four) 1.0 g and 0.56 g that are dried to constant weight respectively, the accurate title, decide, the accurate respectively 50 mL absolute ethyl alcohols that add; Sonicated 30 min (45 ℃) leave standstill filtration, and filter residue is again with ultrasonic 30 min of 30 mL absolute ethyl alcohols; After secondary left standstill filtration, filter residue merged gained filtrating again with ultrasonic 30 min of 20 mL absolute ethyl alcohols; When 45 ℃ of following vacuum are concentrated into the 18 mL left and right sides; Add 2 mL distilled water mixings, and with each 30 mL benzinums decolouring removal of impurities 2 ~ 5 times, closely colourless to petroleum ether layer.Discard benzinum liquid, with raffinate be concentrated into do not have the alcohol flavor after, add 30 mL carrene and 15 mL distilled water fully extract; Standing demix, water layer be again with 20 mL dichloromethane extractions 2 times, the combined dichloromethane extract; 45 ℃ of following evaporated under reduced pressure; Dissolve constant volume in 10 mL measuring bottles with methyl alcohol then, miillpore filter (0.45 μ m) filters, and promptly gets need testing solution.
(3) chromatographic condition: chromatographic column: ACQUITY UPLC BEH Shield RP
18Chromatographic column (2.1 mm * 100 mm, 1.7 μ m); Flowing phase: acetonitrile-water gradient elution program: (0 ~ 8 min, 78 % A; 8 ~ 11 min, 78 % A → 65 % A; 11 ~ 44 min, 65 % A), flow velocity: 0.2 mL min
-1Detect wavelength: 227 nm; Column temperature: 25 ℃; Sample size: 1 μ L.
(4) linear relationship is investigated: getting 1 mL concentration respectively is 0.04 mg mL
-110-deacetylation Bakating III, concentration is 0.035 mg mL
-1Cephalomannine and concentration be 0.072 mg mL
-1Taxol place same 10 mL measuring bottles, use methanol constant volume then, promptly get and mix reference substance solution.Adopt above-mentioned chromatographic condition, will mix reference substance solution respectively sample introduction 1,2,4,6,8,10 μ L analyze, and the record peak area.Content with sample introduction sample is abscissa (X), and peak area value is ordinate (Y) drawing standard curve, and calculates regression equation, tries to achieve the regression equation of 10-deacetylation Bakating III
Y=7.43 * 10
6 X+ 2.58 * 10
4,
r=0.999 8, the range of linearity 0.0401 ~ 0.0040 μ g; The regression equation of Cephalomannine
Y=4.69 * 10
6 X-3.21 * 10
4,
r=0.999 9, the range of linearity 0.0350 ~ 0.0035 μ g; The regression equation of taxol
Y=5.22 * 10
6 X-1.86 * 10
4,
r=0.999 7, the range of linearity 0.0722 ~ 0.0072 μ g.
(5)
Methodological study: the accurate 1 μ L of absorption of precision test mixes reference substance solution; Repeat sample introduction 6 times by above-mentioned chromatographic condition, the RSD of 10-deacetylation Bakating III, Cephalomannine and taxol is respectively 1.07 %, 1.23 %; 1.01 % (n=6) shows that precision is good.
Same need testing solution is got in stability test, and room temperature places 0,1,2,6, measures by above-mentioned chromatographic condition difference sample introduction behind 12,24 h.The result shows that need testing solution is basicly stable in 24 h.The RSD of 10-deacetylation Bakating III, Cephalomannine and taxol peak area is respectively 1.42 %, 1.61 % and 1.73 %.
The reappearance test is got with a collection of Taxus x media and is supplied test agent, by 5 parts of need testing solutions of the parallel preparation of preparation method of above-mentioned need testing solution, measures content by above-mentioned chromatographic condition.The RSD of 10-deacetylation Bakating III, Cephalomannine and taxol peak area is respectively 2.14 %, 2.15 % and 2.61 %.
The average recovery test is got the Taxus x media of measuring 10-deacetylation Bakating III, Cephalomannine and content of taxol and is supplied 6 parts of test agents; Every part of about 1 g; Accurate claim fixed after, add 2 mL and mix reference substance solution, by preparation method's preparation of need testing solution and measure.The average recovery rate of 10-deacetylation Bakating III, Cephalomannine and taxol is respectively 100.42 %, 91.49 % and 92.76 %.
(6) sample determination is got Taxus x media needle and about 1.0 g of extract and 0.56 g; The accurate title, decide; Method by preparing need testing solution prepares need testing solution; Analyze by above-mentioned chromatographic condition sample introduction, calculate 3 kinds of content of effective respectively, the content of taxol is 0.62 mg g in the Taxus x media needle as a result
-1, the content of Cephalomannine is 0.13 mg g
-1, the content of 10-deacetylation Bakating III is 0.36 mg g
-1The content of taxol is 4.32 mg g in the Taxus x media needle extract
-1, the content of Cephalomannine is 0.95 mg g
-1, the content of 10-deacetylation Bakating III is 2.78 mg g
-1
Result of the test shows, contain active ingredients such as Diterpeneses such as taxol, Cephalomannine, 10-deacetylation Bakating III are anticancer, antiviral in Taxus x media needle and the extract thereof, and relative amount is higher than southerm yew.
2, to the test effect of skin eczema:
The test effect of 1～8 pair of skin eczema of embodiment
| Test situation | The test number | Age bracket | Drink fate | Recovery from illness | Take a turn for the better | Total effective rate % |
| Embodiment 1 | 18 | 24～45 | 20 | 13 | 3 | 88.9 |
| Embodiment 2 | 18 | 24～45 | 20 | 14 | 3 | 94.4 |
| Embodiment 3 | 18 | 24～45 | 20 | 12 | 4 | 88.9 |
| Embodiment 4 | 18 | 24～45 | 20 | 10 | 5 | 83.3 |
| Embodiment 5 | 18 | 24～45 | 20 | 10 | 7 | 94.4 |
| Embodiment 6 | 18 | 24～45 | 20 | 13 | 2 | 83.3 |
| Embodiment 7 | 18 | 24～45 | 20 | 15 | 1 | 88.9 |
| Embodiment 8 | 18 | 24～45 | 20 | 13 | 1 | 77.8 |
The product of the present invention that last table data declaration is drunk embodiment 1～8 has effect preferably to skin eczema, and wherein the effect of embodiment 2 is best.
4, to the test therapeutic effect of pruitus:
The test effect of 1～8 pair of pruitus of embodiment
| Test situation | The test number | Age bracket | Drink fate | Recovery from illness | Take a turn for the better | Total effective rate % |
| Embodiment 1 | 30 | ? 18～50 | 15 | 25 | 2 | 90.0 |
| Embodiment 2 | 30 | 18～50 | 15 | 22 | 4 | 86.7 |
| Embodiment 3 | 30 | 18～50 | 15 | 23 | 5 | 93.3 |
| Embodiment 4 | 30 | 18～50 | 15 | 25 | 1 | 86.7 |
| Embodiment 5 | 30 | 18～50 | 15 | 23 | 2 | 83.3 |
| Embodiment 6 | 30 | 18～50 | 15 | 23 | 4 | 90.0 |
| Embodiment 7 | 30 | 18～50 | 15 | 27 | 1 | 93.3 |
| Embodiment 8 | 30 | 18～50 | 15 | 29 | 0 | 96.7 |
The product of the present invention that last table data declaration is drunk embodiment 1～8 has effect preferably to pruitus, and wherein the effect of embodiment 8 is best.
5, to psoriasic test effect:
1～8 pair of psoriasic test effect of embodiment
| Test situation | The test number | Age bracket | Drink fate | Recovery from illness | Take a turn for the better | Total effective rate % |
| Embodiment 1 | 30 | ? 35～60 | 45 | 21 | 6 | 90.0 |
| Embodiment 2 | 30 | 35～60 | 45 | 22 | 4 | 86.7 |
| Embodiment 3 | 30 | 35～60 | 45 | 18 | 10 | 93.3 |
| Embodiment 4 | 30 | 35～60 | 45 | 21 | 6 | 90.0 |
| Embodiment 5 | 30 | 35～60 | 45 | 20 | 8 | 93.3 |
| Embodiment 6 | 30 | 35～60 | 45 | 22 | 7 | 96.7 |
| Embodiment 7 | 30 | 35～60 | 45 | 20 | 5 | 83.3 |
| Embodiment 8 | 30 | 35～60 | 45 | 18 | 6 | 80.0 |
The product of the present invention that last table data declaration is drunk embodiment 1～8 has effect preferably to psoriasis, and wherein the effect of embodiment 6 is best.
Claims (6)
1. tea-drinking article that contain natural plant extracts is characterized in that being made up of the following material of weight percentage: Taxus x media needle extract 45%～70%, sensitive plant herb extract 10%～20%, green tea extract 20%～35%;
Said Taxus x media needle extract adopts following method preparation; May further comprise the steps: the needle of the Taxus x media of drying is put in the container of broken extractor, added 50%～100% ethanol, starting switch; Rotating speed with 8000 r/min～15000 r/min carries out the broken extraction of room temperature texture 1～3 time; Raw material is broken into can passes through 20～40 purpose granularities, if Taxus x media dry weight be 1 kg then the hydrous ethanol consumption be 5～9 liters, each extraction time is 1～3 minute; With the extract suction filtration, discard filter residue, the extract that merging obtains is at 50 ℃～80 ℃, and vacuum is to adopt Reduced Pressure Concentration Device to carry out flash concentration under the 0.095 Mpa condition, regulates the feed liquor speed of solution to be concentrated, with 200～350 mLmin
-1Flow be concentrated into 1/4～1/8 of original volume repeatedly, then concentrate is proceeded vacuum drying and becomes dry powder, with obtaining Taxus x media extract dry powder behind the mortar porphyrize;
Said sensitive plant preparation method of extract; May further comprise the steps: the sensitive plant herb of drying is put in the container of broken extractor, added 50%～80% ethanol, starting switch; Rotating speed with 8000 r/min～15000 r/min carries out the broken extraction of room temperature texture 2～3 times; Raw material is broken into can passes through 20～40 purpose granularities, if sensitive plant dry weight be 1 kg then the hydrous ethanol consumption be 6～12 liters, each extraction time is 2～5 minutes; With the extract suction filtration, discard filter residue, the extract that merging obtains is at 50 ℃～70 ℃, and vacuum is to adopt Reduced Pressure Concentration Device to carry out flash concentration under the 0.095 Mpa condition, regulates the feed liquor speed of solution to be concentrated, with 150～300 mLmin
-1Flow be concentrated into 1/5～1/10 of original volume repeatedly, then concentrate is proceeded vacuum drying and becomes dry powder, with obtaining sensitive plant extract dry powder behind the mortar porphyrize;
The preparation method of said green-tea extract; May further comprise the steps: the green tea of drying is put in the container of broken extractor, added 50%～80% ethanol, starting switch; Rotating speed with 8000 r/min～15000 r/min carries out the broken extraction of room temperature texture 1～2 time; Raw material is broken into can passes through 20～60 purpose granularities, if green tea dry weight be 1kg then the hydrous ethanol consumption be 7～14 liters, each extraction time is 1～3 minute; With the extract suction filtration, discard filter residue, the extract that merging obtains is at 50 ℃～70 ℃, and vacuum is to adopt Reduced Pressure Concentration Device to carry out flash concentration under the 0.095 Mpa condition, regulates the feed liquor speed of solution to be concentrated, with 150～300 mLmin
-1Flow be concentrated into 1/6～1/12 repeatedly, then concentrate is proceeded vacuum drying and becomes dry powder, with obtaining green-tea extract dry powder behind the mortar porphyrize.
2. a kind of tea-drinking article that contain natural plant extracts as claimed in claim 1, it is characterized in that: the content of Taxus x media needle extract is 50%～65%; The content of sensitive plant herb extract is 12%～18%; The content of green tea extract is 22%～30%; These three kinds of components contents sums are absolutely.
3. a kind of tea-drinking article that contain natural plant extracts as claimed in claim 1 is characterized in that in the said Taxus x media needle preparation method of extract: concentration of ethanol is 60%～90% during broken the extraction; Rotating speed is 10000 r/min～12000 r/min; The temperature of flash concentration is 55 ℃～75 ℃; Feed liquor speed 250～320 mLmin of solution to be concentrated
-1Concentrate is concentrated into 1/5～1/7 of original volume.
4. a kind of tea-drinking article that contain natural plant extracts as claimed in claim 1 is characterized in that in the said sensitive plant preparation method of extract: concentration of ethanol is 60%～70% during broken the extraction; Rotating speed is 10000 r/min～12000 r/min; The temperature of flash concentration is 55 ℃～65 ℃; Feed liquor speed 200～280 mLmin of solution to be concentrated
-1Concentrate is concentrated into 1/6～1/9 of original volume.
5. a kind of tea-drinking article that contain natural plant extracts as claimed in claim 1 is characterized in that among the preparation method of said green-tea extract: concentration of ethanol is 60%～70% during broken the extraction; Rotating speed is 10000 r/min～12000 r/min; The temperature of flash concentration is 55 ℃～65 ℃; Feed liquor speed 200～280 mLmin of solution to be concentrated
-1Concentrate is concentrated into 1/8～1/10 of original volume.
6. a kind of application of tea-drinking article in preparation control skin eczema, pruitus, psoriasic preparation that contains natural plant extracts as claimed in claim 1.
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| CN102764379A (en) * | 2012-07-14 | 2012-11-07 | 张益军 | Medicinal tea bag for treating chronical blood vacuity wind-dryness eczema |
| CN102895269B (en) * | 2012-09-05 | 2014-09-10 | 浙江省中医药研究院 | Application of yew in preparation of drug for eczema treatment, and composition |
| CN103070261B (en) * | 2013-02-05 | 2014-08-27 | 普洱市红宝生物科技有限公司 | Formula of red bean tea powder and production method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1133692A (en) * | 1996-01-31 | 1996-10-23 | 刘培儒 | Taxus chinensis beverage series and preparing process thereof |
| CN1602715A (en) * | 2004-11-16 | 2005-04-06 | 李万祥 | Bag tea production method using Chinese yew as material |
| CN101543309A (en) * | 2009-05-09 | 2009-09-30 | 戴瑞萍 | Natural plant antioxidant and its preparation method |
| CN101653470A (en) * | 2009-06-02 | 2010-02-24 | 华宝食用香精香料（上海）有限公司 | Sensitive plant total alkaloid extract and preparing method and application thereof |
| CN101671319A (en) * | 2009-09-18 | 2010-03-17 | 应成杰 | Taxus nontoxic extract process |
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- 2011-05-19 CN CN 201110129753 patent/CN102258094B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1133692A (en) * | 1996-01-31 | 1996-10-23 | 刘培儒 | Taxus chinensis beverage series and preparing process thereof |
| CN1602715A (en) * | 2004-11-16 | 2005-04-06 | 李万祥 | Bag tea production method using Chinese yew as material |
| CN101543309A (en) * | 2009-05-09 | 2009-09-30 | 戴瑞萍 | Natural plant antioxidant and its preparation method |
| CN101653470A (en) * | 2009-06-02 | 2010-02-24 | 华宝食用香精香料（上海）有限公司 | Sensitive plant total alkaloid extract and preparing method and application thereof |
| CN101671319A (en) * | 2009-09-18 | 2010-03-17 | 应成杰 | Taxus nontoxic extract process |
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