CN103202865B - Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof - Google Patents
Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof Download PDFInfo
- Publication number
- CN103202865B CN103202865B CN201310154597.0A CN201310154597A CN103202865B CN 103202865 B CN103202865 B CN 103202865B CN 201310154597 A CN201310154597 A CN 201310154597A CN 103202865 B CN103202865 B CN 103202865B
- Authority
- CN
- China
- Prior art keywords
- ramulus
- micronization
- taxi cuspidatae
- folium taxi
- root
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to Chinese yew micronized particles, a compound for health bath obtained by using micronized Chinese yew particle and a preparation method thereof. The preparation method of the micronized Chinese yew particles comprises the following steps of: mixing Chinese yew bark and/or root and micronized solid auxiliary agent so as to form a solid mixture; and crushing the solid mixture in a micronized manner so as to form mixture particles with particle sizes D(90) being smaller than or equal to 15 microns. According to the micronized method disclosed by the invention, the dissolution rate of effective constituents of Chinese yew bark and root is greatly improved, the utilization ratio of Chinese yew bark and root is greatly improved, the adhesion and blockage conditions in crushing are also reduced, the medicine loss is few, and the crushing efficiency of micronized medicine can be obviously improved.
Description
Technical field
The present invention relates to Ramulus et folium taxi cuspidatae micronized particle, for the compositions that contains this micronized particle of health bath, health-care lotion and preparation method thereof.Micronized particle of the present invention not only greatly improves the dissolution of rare Ramulus et folium taxi cuspidatae peel of stem and root effective ingredient thereof, greatly improve the utilization rate of Ramulus et folium taxi cuspidatae peel of stem and root, also reduce bonding, the clogging in pulverizing, also can significantly improve the crush efficiency of micronized medicine.
Background technology
The Ji Yuan of Ramulus et folium taxi cuspidatae is taxaceae (Taxaceae), Chinese yew genus plants Ramulus et folium taxi cuspidatae.Existing 4 kinds of China and 1 mutation, be Chinese Ramulus et folium taxi cuspidatae (Taxus chinensis(Pilger) Rehd.), Ramulus et folium taxi cuspidatae, T. yunnanensis (T.YUENNAN ENSIS CHENG ET L.K.FU), Xizang Taxus chinensis (T.WALL ICHIANA IUCC) and Taxus mairei (T.CHINENSIS VAR MAIREI(LEMEE ET L ' EVL) CHENG ET L.K.FU) (mutation), be extensively distributed in the ground such as China's SOUTH OF GANSU, Southern Shaanxi, West of Hubei Province, Sichuan.Ramulus et folium taxi cuspidatae also can manually be planted, and national most area all can be planted, and there is extensive cultivation on the ground such as present Sichuan, Guangxi, Shandong, Fujian.
Ramulus et folium taxi cuspidatae is quaternary glacier Relict Plant in period, world rare and endangered species, and taxus resource should add protection, and the United Nations also prohibites felling.It likes the weather of dark and damp environment, warm and moist, not only has drought-enduring cold-resistant, disease and insect resistance, stronger rudiment ability, and poor growth, the feature such as the life-span is long, and there is high value of exploiting and utilizing.The paclitaxel extracting from bark of Ramulus et folium taxi cuspidatae and branch and leaf is the medicament of the cancer-resisting of generally acknowledging in the world; Paclitaxel is used for the treatment of advanced breast cancer, pulmonary carcinoma, ovarian cancer and incidence cancer, soft tissue cancer and digestive tract cancer.Ramulus et folium taxi cuspidatae is used for the treatment of leukemia, nephritis, diabetes and POLYCYSTIC KIDNEY DISEASE.It also has the effects such as inducing diuresis to remove edema, treatment nephropathy, diabetes, nephritis edema, dysuria, gonorrhea.Also find by research: root is the highest organ of content of taxol except bark.
Domestic micronizing is the new and high technology developing rapidly the eighties in 20th century, refers to and utilizes machinery or hydrokinetic approach that raw material is processed into micropowder or even nano powder.To the later stage nineties, at the field of Chinese medicines, superfine communication technique is also progressively opened up the combination of advanced crushing technology and Chinese medicine, improve the quality of Chinese medicinal powder, improve the utilization rate of Chinese medicine, increased dissolution of composition etc., represented wide application prospect.Domestic to many single medicinal materials, as Cordyceps, Ganoderma spore, pollen, Cornu Saigae Tataricae, Rhizoma Coptidis, Radix Notoginseng, Rhizoma Gastrodiae, Cornu Cervi Pantotrichum, Margarita, Radix Ginseng Rubra, Radix Panacis Quinquefolii, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Placenta Hominis, Folium Mori, the Rhizoma Anemarrhenae, Radix Puerariae, Fructus Aurantii, Herba Houttuyniae, Hirudo etc. have carried out micronizing research.Because the specific surface area of ultrafine powder is larger, improve dissolution and the bioavailability of Chinese medicine; Strengthen the drug effect of Chinese medicine; Can reduce dosage, conservation, raises the efficiency, and reduces costs.
Drug micronization has several different methods, comprising comminution by gas stream, ball-milling method, ultrasonic method, spray drying method, supercritical fluid technology etc.Micropowder has strong reunion tendency in preparation, storage process, because intergranular exists Van der Waals force, liquid bridge power, electrostatic force etc.Some drug micronization methods are by adding liquid medium (as water, ethanol etc.) to dissolve or dispersion medicine, the bonding phenomenon producing while mutually shock to reduce or to eliminate electrostatic interaction, Van der Waals force or the drug particles of drug powder.But the modes such as micronized medicine prepared by this wet method conventionally need to be dry with spraying, vacuum drying or microwave drying remove liquid medium, just can obtain solid drugs.But this process exists that medicine is unstable, drug particle size is wayward, difficulty is produced in coalescent, medicine crystal phase transition, organic solvent residual, amplification to drug particle again, energy consumption is large and efficiency is low, production cost increases, even have the shortcomings such as potential safety hazard.Especially also need to slough added liquid medium, therefore cause the operating time long and complicated.Therefore, do not add any liquid medium, it is a kind of simple and quick method that solid drugs powder is directly carried out to micronization.But a lot of medical solid powder are directly pulverized also and are had problems, such as: with comminution by gas stream directly pulverizing can there is the shortcomings such as coalescent, obstruction tract, efficiency are low; And with ball-milling method directly pulverizing can there is the shortcomings such as adhesion, molding, weak effect.These shortcomings all can cause the drug powder metallization processes can not scale and industrialization, even all cannot carry out at laboratory.
Micronizing mainly adopts abrading type disintegrator, mechanical impact crusher, jet mill etc. at present.
Summary of the invention
Object of the present invention is just to provide a kind of simple process, the method for micronization that is applicable to Ramulus et folium taxi cuspidatae peel of stem and root that efficiency is high.By Ramulus et folium taxi cuspidatae peel of stem and root are carried out to micronizing processing, can improve the dissolution of paclitaxel, conservation, raises the efficiency, and reduces costs, to the rare resource of protection Ramulus et folium taxi cuspidatae, significant.Specifically in the micronization technique of prepared slices of Chinese crude drugs Ramulus et folium taxi cuspidatae peel of stem and root, by adding a certain amount of micronization auxiliary agent, greatly improve micronization efficiency, and can effectively prevent the shortcoming such as pipeline obstruction in comminution by gas stream, drug loss is little, and makes particle diameter D (90) and be less than or equal to the drug microparticles of 10 microns.
A first aspect of the present invention, a kind of Ramulus et folium taxi cuspidatae micronized particle is provided, its be by by dry to moisture be 4.0 % by weight (, the content of the moisture in Taxus peel of stem and/or root) below, preferably the Taxus peel of stem below 3.0 % by weight and/or root (are preferably the coarse powder of Taxus peel of stem and/or root, for example Ramulus et folium taxi cuspidatae peel of stem and/or undercut are become to 1.0～4.0 millimeters of thickness, preferably 1.8～2.2 millimeters, root diameter or skin length are 2.0～20.0 millimeters, preferably 5.0～20.0 millimeters, preferably 10.0～12.0 millimeters and obtain coarse powder, or 1.0～4.0 millimeters of minor axis, preferably 1.8～2.2 millimeters, 5.0～20.0 millimeters of major diameters, the preferably coarse powder of 10.0～12.0 millimeters.Preferably, coarse powder is crossed 10～80 mesh sieves, preferably cross 40～80 mesh sieves, more preferably cross 60 mesh sieves) with solid-state micronization auxiliary agent according to 100:10～40(Taxus peel of stem and/or root: solid-state micronization auxiliary agent), preferably 100:10～30, more preferably the weight ratio of 100:15～25 is mixed, form solid mixt, then described solid mixt is carried out to micronization pulverizing, make particle diameter D (90) be less than or equal to 15 microns, the granulate mixture that is preferably less than or equal to 10 microns or 8 microns (for example, in 1～10 micrometer range or in 1～5 micrometer range) and obtain.
Wherein, the Ji Yuan of described Ramulus et folium taxi cuspidatae is taxaceae (Taxaceae), can be any one or the two or more mixture in Ramulus et folium taxi cuspidatae, for example Chinese Ramulus et folium taxi cuspidatae (Taxus chinensis(Pilger) Rehd.), Ramulus et folium taxi cuspidatae, T. yunnanensis (T.Yuennan Ensis Cheng ET L.K.FU), Xizang Taxus chinensis (T.Wall Ichiana IUCC) and Taxus mairei (T.Chinensis VAR Mairei(LEMEE ET L ' EVL) Cheng ET L.K.FU) any one or two or more mixture in (mutation).From the angle of protection Chinese yew, should select Ramulus et folium taxi cuspidatae more than ten ages of cultivation.
Prepare the required raw material of Ramulus et folium taxi cuspidatae micronized particle of the present invention and can get peel of stem, root or the peel of stem of Ramulus et folium taxi cuspidatae and the mixture of root.In the time getting the mixture of peel of stem and root, both weight ratios are not limited, preferably peel of stem and root be with weight ratio 100: 50-100:200, or 100: 80-100:180, or 100: 100-100:150 mixes.
Described solid-state micronization auxiliary agent, refers to the micronization of assisting Ramulus et folium taxi cuspidatae peel of stem and/or root, plays the reagent that prevents from blocking pulverizing chamber and gas channel in the time that comminution by gas stream is processed.Preferentially be selected from one or more in Sal (especially powder salt), silicon dioxide, medicinal Pulvis Talci.Because not adding liquid medium in described method, avoid that drug particle size is wayward, the shortcomings such as the large and efficiency of difficulty, energy consumption is low are produced in coalescent, organic solvent residual, amplification to drug particle again.Sal is as a part for micronization auxiliary agent, and Sal molecule is polar molecule, the cementation producing when electrostatic interaction, Van der Waals force or the drug particles that can reduce drug powder clashes into mutually.Also improved comminution by gas stream directly pulverizing can exist coalescent, stop up the shortcomings such as tract, efficiency are low.Solid-state micronization auxiliary agent is with respect to 100 weight portion Taxus peel of stem and/or root during lower than 10 weight portion, and auxiliary micronized effect is insufficient, and while exceeding 30 weight portion, does not produce larger auxiliary micronized effect.
More preferably, described solid-state micronization auxiliary agent is the composite solid micronization auxiliary agent of Sal, medicinal Pulvis Talci composition, be that medicine (Taxus peel of stem and/or root) is about (but being not limited to) 100: 5～20: 5～20 with Sal, medicinal Pulvis Talci weight ratio, preferably 100: 8～15: 8～15, most preferably from about 100: 10: 10, now, smooth and easy, the good results of micronization crushing operation.Add a small amount of Sal to contribute to micronization, and in the time putting in body lotion, can play the effect of normal saline, mediation medicine.In the time using single solid-state micronization auxiliary agent of planting as Sal (especially powder salt), silicon dioxide, medicinal Pulvis Talci, the weight ratio of medicine (Taxus peel of stem and/or root) and any solid-state micronization auxiliary agent (as Sal (especially powder salt), silicon dioxide or medicinal Pulvis Talci) is about 100: 10～and 40, preferably 100: 15～30, most preferably 100: 18～25, for example 100: 20.
Preferably, solid-state micronization auxiliary agent was dried in advance to moisture 5.0 % by weight before mixing with Ramulus et folium taxi cuspidatae peel of stem and/or root, preferably below 4.0 % by weight, more preferably below 3.0 % by weight.
Described method of micronization can be the method for micronization of conventional not annex solution body medium, such as comminution by gas stream, ball-milling method, ultrasonic method, spray drying method etc.Preferably comminution by gas stream.
Comminution by gas stream is to utilize the energy of high velocity air to make granule produce each other impact, collision and friction, thereby causes a kind of superfine technique of breakage of particles refinement.Being different from mechanical activation comminution and relying on the impact comminution to material such as blade or tup, is that a kind of low temperature is pulverized without medium, and production process clean environment firendly is particularly suitable for the pulverizing of thermal sensitivity, low melting point, sugary part and volatile material.
Be applicable to airflow pulverization method of the present invention and device and be not particularly limited, can adopt commercially available air flow crushing device, and carry out comminution by gas stream according to conditioned disjunction parameter recommended by the manufacturer.
Second aspect of the present invention provides a kind of preparation method of Ramulus et folium taxi cuspidatae micronized particle, described method comprise by dry to moisture be below 4.0 % by weight, preferably the Taxus peel of stem below 3.0 % by weight and/or root (are preferably the coarse powder of Taxus peel of stem and/or root, for example Ramulus et folium taxi cuspidatae peel of stem and/or undercut are become to 1.0～4.0 millimeters of thickness, preferably 1.8～2.2 millimeters, root diameter or skin length are 2.0～20.0 millimeters, preferably 5.0～20.0 millimeters, preferably 10.0～12.0 millimeters and obtain coarse powder, or 1.0～4.0 millimeters of minor axis, preferably 1.8～2.2 millimeters, 5.0～20.0 millimeters of major diameters, the preferably coarse powder of 10.0～12.0 millimeters.Preferably, coarse powder is crossed 10～80 mesh sieves, preferably cross 40～80 mesh sieves, more preferably cross 60 mesh sieves) with solid-state micronization auxiliary agent according to 100:10～40(Taxus peel of stem and/or root: solid-state micronization auxiliary agent), preferably 100:10～30, more preferably the weight ratio of 100:15～25 is mixed, form solid mixt, then described solid mixt is carried out to micronization pulverizing, make particle diameter D (90) be less than or equal to 15 microns, be preferably less than or equal to 10 microns or 8 microns.
In said method, the Ji Yuan of described Ramulus et folium taxi cuspidatae is taxaceae (Taxaceae), can be any one or the two or more mixture in Ramulus et folium taxi cuspidatae, for example Chinese Ramulus et folium taxi cuspidatae (Taxus chinensis(Pilger) Rehd.), Ramulus et folium taxi cuspidatae, T. yunnanensis (T.Yuennan Ensis Cheng ET L.K.FU), Xizang Taxus chinensis (T.Wall Ichiana IUCC) and Taxus mairei (T.Chinensis VAR Mairei(LEMEE ET L ' EVL) Cheng ET L.K.FU) any one or two or more mixture in (mutation).From the angle of protection Chinese yew, should select Ramulus et folium taxi cuspidatae more than ten ages of cultivation.
In described preparation method, raw material can be got peel of stem, root or the peel of stem of Ramulus et folium taxi cuspidatae and the mixture of root.In the time getting the mixture of peel of stem and root, both weight ratios are not limited, preferably peel of stem and root be with weight ratio 100: 50-100:200, or 100: 80-100:180, or 100: 100-100:150 mixes.
Described solid-state micronization auxiliary agent is preferentially selected from one or more in Sal (especially powder salt), silicon dioxide, medicinal Pulvis Talci.
Preferably, described solid-state micronization auxiliary agent is the composite solid micronization auxiliary agent of Sal, medicinal Pulvis Talci composition, be that medicine and Sal, medicinal Pulvis Talci weight ratio are about 100: 5～20: 5～20 (but being not limited to), preferably 100: 8～15: 8～15, most preferably from about 100: 10: 10, now, smooth and easy, the good results of micronization crushing operation.Add a small amount of Sal to contribute to micronization, and in the time putting in body lotion, can play the effect of normal saline, mediation medicine.
Preferably, solid-state micronization auxiliary agent was dried in advance to moisture 5.0 % by weight before mixing with Ramulus et folium taxi cuspidatae peel of stem and/or root, preferably below 4.0 % by weight, more preferably below 3.0 % by weight.
Described method of micronization can be the method for micronization of conventional not annex solution body medium, such as comminution by gas stream, ball-milling method, ultrasonic method, spray drying method etc.Preferably comminution by gas stream.
Third aspect of the present invention provides a kind of compositions for health bath, described compositions comprises Radix Astragali prepared slices of Chinese crude drugs component and above Ramulus et folium taxi cuspidatae micronized particle component of the present invention or by the prepared Ramulus et folium taxi cuspidatae micronized particle component of method of the present invention, the weight ratio of two kinds of components is 50:10～150, preferably 50:40～60, preferably 50:45～55, more preferably for example 50:50.Or, described compositions comprises by water or ethanol water carries out lixiviate and then concentrates the extract obtaining Chinese medicine astragalus decoction pieces component and above-mentioned Ramulus et folium taxi cuspidatae micronized particle component, wherein the weight ratio of Ramulus et folium taxi cuspidatae micronized particle component and Chinese medicine astragalus decoction pieces is 50:10～150, preferably 50:30～100, preferably 50:40～60, preferably 50:45～55, more preferably for example 50:50.Here two kinds of compositionss are respectively the form of solid or liquid.
The described compositions for health bath, take Ramulus et folium taxi cuspidatae as monarch, has diuresis, stimulates the menstrual flow, the effect (" Chinese medicine voluminous dictionary " 2342 pages) of blood fat reducing.Take the Radix Astragali as minister, benefit is defended consolidating superficial resistance, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema.Assistant, with Pulvis Talci, has relieving stranguria by diuresis, clearing away summer-heat effect.More with a little Sal for making, be in harmonious proportion all taste property of medicine, have the effect of similar normal saline concurrently.
For preparing the method for above-mentioned composition, the form of above-mentioned composition (solid or liquid) is not particularly limited.For example a kind of preferred preparation method comprises:
(1) by the micronized particle of Ramulus et folium taxi cuspidatae peel of stem of the present invention and/or root, carry out compound membrane bag packing, 50 grams every bag.
(2) by the Radix Astragali prepared slices of Chinese crude drugs, carry out compound membrane bag packing, 10～150 grams every bag, preferably 40～60 grams, preferably 45～55 grams, for example 50 grams.
(3) by two bags of ingredients compounds (solid composite) of step (1) and (2).
Or, in another embodiment, the above-mentioned compositions for health bath can be passed through the micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root 100 weight portions and Radix Astragali decoction pieces 10～150 weight portions (preferably 30-100 weight portion, preferably 40～60 weight portions, preferably 45～55 weight portions) together for example, in water or ethanol water (30～75 quality % aqueous solutions of ethanol, 45～75 quality % aqueous solutions, 75 quality % aqueous solutions) in lixiviate at normal temperatures for example 10～24 hours or boiling under state lixiviate for example 5 minutes～1 hour, isolate again liquid, optionally concentrated (be for example concentrated into original volume 3/4～1/2) packs afterwards, obtain the fluid composition for health bath of the present invention, be wherein the micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root and the dry weight of Radix Astragali decoction pieces 5 times～12 times for the water of lixiviate or the amount of ethanol water, preferably 6～10 times.
The application process of described solid composite is:
By above-mentioned solid composite (micronized particle of 50g Ramulus et folium taxi cuspidatae peel of stem and/or root and 10～150g, preferably 40～60 grams of Radix Astragali decoction pieces) use the drinking water boiling to brew, for example brew into 100 liters, covered and enclosed a period of time, for example 10 minutes, make health-care lotion, can be used for Saunas, dipping bath, shower etc., be preferred for Saunas, dipping bath.As for health-care foot bath, the consumption of the micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root and Radix Astragali decoction pieces takes the circumstances into consideration to reduce by half.
Compositions for health bath of the present invention has elimination skin pruritus (antipruritic), obviously improves sleep, relieving fatigue, diuresis perspire, dredge the meridian passage, goes painful abdominal mass relieving distension, alleviates the effect of the stiff and pain of skeleton, is particularly useful for skin pruritus, fatigue, sleep disorder, myasthenia of limbs, aches all over, the skin pruritus of diabetic dermopathy, chronic kidney decay etc.
Advantage of the present invention further comprises:
(a) micronisation process of the present invention can effectively reduce the phenomenon such as bonding, obstruction of pressed powder in directly pulverizing.
(b) micronization technique of the present invention is simple, crush efficiency is high, loss is few.
(c) drug microparticles of the present invention, owing to having added composite micro-powder auxiliary agent, promotes micronized effect more obvious, and medicinal Pulvis Talci is one of active ingredient of health-care foot bath or Saunas, and a small amount of Sal has the effect of similar normal saline.
(d) with the pharmaceutical composition of micronization process of the present invention, extract under (boiled water punching is stirred) simplifying, need not decoct again, the processing such as lixiviate; Drug dissolution is high, greatly improves the effective rate of utilization of rare Ramulus et folium taxi cuspidatae peel of stem and root, to the rare resource of protection Ramulus et folium taxi cuspidatae, significant.Micronization generally can be saved Ramulus et folium taxi cuspidatae medical material 30%～70%, has reduced the wasting of resources.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment pick out representative study on classics paragraph from the numerous experiments of the present invention, they are only not used in and limit the scope of the invention for the present invention is described.The experimental technique of unreceipted actual conditions in the following example, conventionally according to normal condition, or the condition of advising according to manufacturer is carried out.
Wherein, in the embodiment of the present invention, Ramulus et folium taxi cuspidatae peel of stem used and root are all dried to moisture below 4.0%.
The present invention's solid-state micronization auxiliary agent used, Sal and medicinal Pulvis Talci or silicon dioxide are dried to moisture below 4.0%.
The envionmental humidity of micronization experiment that the present invention carries out remains on below 30% as far as possible.
Ramulus et folium taxi cuspidatae of the present invention is selected from Chinese yews more than ten ages of cultivation.
Comparative example 1: the prepared slices of Chinese crude drugs mixture of Ramulus et folium taxi cuspidatae peel of stem and root is directly carried out to comminution by gas stream.
The prepared slices of Chinese crude drugs mixture coarse powder of Ramulus et folium taxi cuspidatae peel of stem and root is crossed after 60 mesh sieves, do not add any medium (micronization auxiliary agent), directly carry out the pulverizing of dry method micronization with jet mill (the JGM-H200 type jet mill of Huali Co., Ltd), pulverize the about 5-8bar of pressure.Granularity after pulverizing is that D (50) is 256.8 μ m, and D (90) is 874.6 μ m, does not reach micronization effect.
Found that, the coarse powder of Ramulus et folium taxi cuspidatae peel of stem and root, very easily sticks in pulverizing chamber, stops up pulverizing chamber and high pressure draught passage, affects crush efficiency, even makes to pulverize to carry out smoothly.Jet mill is taken apart, and finding has floccule and paste in crushing chamber, and water cleans, and then dries.Thoroughly the clean rear micronization that continues is pulverized, and has equally felt jam problem.
Embodiment 1: the common micronization of coarse powder that adds solid-state micronization auxiliary agent Sal and Ramulus et folium taxi cuspidatae peel of stem, root is pulverized.
The coarse powder of 500g Ramulus et folium taxi cuspidatae peel of stem, root and 100g Sal coarse powder (medicine and solid-state micronization auxiliary agent weight ratio are about 100: 20) are crossed respectively to 60 mesh sieves, after mixing, carry out micronization pulverizing with jet mill (the JGM-H200 type jet mill of Huali Co., Ltd), pulverize pressure and be about 6-8bar, feed rate is 50 ━ 75g/min, and micronization processes once.Micronization crushing operation is smooth and easy.Receive to obtain micronized medicine 588.6g, yield is 98.1%.
Measure the particle size distribution of micronizing materials with Ma Erwen Particle Size Analyzer, result demonstration, D (50) is 5.6 μ m, D (90) is 12.4 μ m.
By the coarse powder of Ramulus et folium taxi cuspidatae peel of stem, root and the common micronization of micronization auxiliary agent Sal, micronization efficiency is high, effective, has no clogging.
Embodiment 2: the common micronization of coarse powder that adds solid-state micronization auxiliary agent medicinal Pulvis Talci and Ramulus et folium taxi cuspidatae peel of stem, root is pulverized.
The coarse powder of 500g Ramulus et folium taxi cuspidatae peel of stem, root and 100g medicinal Pulvis Talci coarse powder (medicine and solid-state micronization auxiliary agent weight ratio are about 100: 20) are crossed respectively to 60 mesh sieves, after mixing, carry out micronization pulverizing with jet mill (the JGM-H200 type jet mill of Huali Co., Ltd), pulverize pressure and be about 6-8bar, feed rate is 50 ━ 75g/min, and micronization processes once.Micronization crushing operation is smooth and easy.Receive to obtain micronized medicine 590.4g, yield is 98.4%.
Measure the particle size distribution of micronizing materials with Ma Erwen Particle Size Analyzer, result demonstration, D (50) is 5.2 μ m, D (90) is 9.2 μ m.After micronization, in jet mill tract, have no bonding phenomenon.
Embodiment 3: the common micronization of coarse powder that adds solid-state micronization auxiliary agent silicon dioxide and Ramulus et folium taxi cuspidatae peel of stem, root is pulverized.
The coarse powder of 500g Ramulus et folium taxi cuspidatae peel of stem, root and 100g silicon dioxide coarse powder (medicine and solid-state micronization auxiliary agent weight ratio are about 100: 20) are crossed respectively to 60 mesh sieves, after mixing, carry out micronization pulverizing with jet mill (the JGM-H200 type jet mill of Huali Co., Ltd), pulverize pressure and be about 6-8bar, feed rate is 50 ━ 75g/min, and micronization processes once.Micronization crushing operation is smooth and easy.Receive to obtain micronized medicine 589.5g, yield is 98.2%.
Measure the particle size distribution of micronizing materials with Ma Erwen Particle Size Analyzer, result demonstration, D (50) is 5.1 μ m, D (90) is 9.0 μ m.After micronization, in jet mill tract, have no bonding phenomenon.
Embodiment 4: the common micronization of coarse powder that adds composite solid micronization auxiliary agent Sal, medicinal Pulvis Talci and Ramulus et folium taxi cuspidatae peel of stem, root is pulverized.
The coarse powder of 500g Ramulus et folium taxi cuspidatae peel of stem, root and 50g Sal, 50g medicinal Pulvis Talci coarse powder (medicine and solid-state micronization auxiliary agent weight ratio are about 100: 10: 10) are crossed respectively to 60 mesh sieves, after mixing, carry out micronization pulverizing with jet mill (the JGM-H200 type jet mill of Huali Co., Ltd), pulverize pressure and be about 6-8bar, feed rate is 50-75g/min, and micronization processes once.Micronization crushing operation is smooth and easy.Receive to obtain micronized medicine 587.8g, yield is 98.0%.
Measure the particle size distribution of micronizing materials with Ma Erwen Particle Size Analyzer, result demonstration, D (50) is 5.0 μ m, D (90) is 9.2 μ m.After micronization, in jet mill tract, have no bonding phenomenon.
Sal, medicinal Pulvis Talci, silicon dioxide or its any compositions are as composite solid micronization auxiliary agent, and the not strict restriction of ratio, pulverizes with the common micronization of coarse powder of Ramulus et folium taxi cuspidatae peel of stem, root, through long run test, in jet mill tract, have no bonding or clogging.Micronization crushing operation is smooth and easy.Carry out micronization pulverizing with the JGM-H200 type jet mill of Huali Co., Ltd, after crushing operation is skilled, feed rate can reach 75 ━ 90g/min, and micronized drug particle size all meets the granularity requirements of expection.Micronization yield all reaches 98.0% left and right.Illustrate that this micronization technique can amplify production.
Embodiment 5 is for the solid composite of health bath
The Ramulus et folium taxi cuspidatae peel of stem that above-described embodiment 4 is formed and the micronized particle of root, carry out compound membrane bag packing, 50 grams every bag.
By the Radix Astragali prepared slices of Chinese crude drugs, carry out compound membrane bag packing again, 50 grams every bag.
By above-mentioned two bags of ingredients compound taxol health-care lotion solid composites.
By the compound taxol health-care lotion solid composite of above-mentioned two bags of ingredients, use the Drink water boiling to brew into 100 liters, covered and enclosed 10 minutes, makes health-care lotion, can be used for Saunas.Health-care foot bath takes the circumstances into consideration to reduce by half.
Embodiment 6 is for the fluid composition of health bath
The micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root is being boiled together with Radix Astragali decoction pieces in 10 times of water gagings of the micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root and the dry weight of Radix Astragali decoction pieces under state to lixiviate 10 minutes, isolate liquid (lixiviating solution), reconcentration to lixiviating solution original volume 1/2 after pack, obtain the fluid composition for health bath of the present invention.
Aforesaid liquid compositions is added in 100 liters of hot water for bathing to 100ml aforesaid liquid compositions, make health-care lotion, can be used for dipping bath, shower, Saunas, health-care foot bath etc.
The compositions for health bath described in embodiment 5 and embodiment 6, take Ramulus et folium taxi cuspidatae as monarch, has diuresis, stimulates the menstrual flow, the effect (" Chinese medicine voluminous dictionary " 2342 pages) of blood fat reducing.Take the Radix Astragali as minister, benefit is defended consolidating superficial resistance, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema.Assistant, with Pulvis Talci, has relieving stranguria by diuresis, clearing away summer-heat effect.More with a little Sal for making, be in harmonious proportion all taste property of medicine, have the effect of similar normal saline concurrently.There is health-care lotion that compositions makes applicable to improving sleep, relieving fatigue, diuresis perspire, goes painful abdominal mass relieving distension, dredge the meridian passage, enhances metabolism.
According to the rough estimates that have data, the health-care lotion Saunas of preparing by the solid health-care compositions of embodiment 5, be applicable to above-mentioned sign and treat 376 examples (comprising fatigue and weak, skin pruritus, intractable sleep disorder, diabetic dermopathy person, the person of aching all over), effective (symptom is eliminated completely) 161 examples, effectively (symptom is obviously improved) 201 examples, invalid 14 examples, total effective rate 96%.Patient's Saunas once, each 1 hour, just can obviously improve sleep, relieving fatigue, diuresis perspire, dredge the meridian passage, alleviates the stiff and pain of skeleton.Saunas 3 times next day of continuously, patient generally reflects that whole body is light, spirit multiplication, above-mentioned many symptoms all disappear.
Model case 1: Pan, the machine-operated civil servant in Fuding City of Fujian Province, man, 55 years old.Be busy with one's work, the work of staying up late of often working extra shifts or extra hours, quite takes again energy, causes insomnia cardiopalmus, neurolysis, gastrointestinal upset, abdominal distention and anorexia, the serious overdraw profit of muscle power.Patient's Saunas once, approximately 1 hour, it is sedate that fall asleep by patient's readme, tired releasing, and whole body is light, spirit multiplication, abdominal distention sense disappears, the intestines and stomach digestion normal.
Model case 2: remaining certain, the civilian of Fuding City of Fujian Province, man, 38 years old.Long-time computer work.Stiff and the hurt like hell of neck and shoulder part skeleton.The next day continuous Saunas 3 times, the stiff and pain of patient's readme neck and shoulder part skeleton disappears, activity freely, evident in efficacy.
Model case 3: swim certain, people from Taishun County, Zhejiang Province, rural migrant worker.Man, 38 years old.The work of outdoor long period of summer-heat sky, malaise, Mian Se Cang is white, and abdomen is every distension, soreness of waist and knee joint, dizzy pupil.Drink after hot boiled water, take and this product Saunas through full Shen Pinch, of pink and healthy-looking, abdomen disappears every distension, and antisecosis is as front.
Model case 4: journey, people from Longquan County, Zhejiang Province, retirement is in.Female, 68 years old.There are 12 years diabetic history.Refractory pruritus 4 years, especially with the autumn and winter for very, pruritus impact is fallen asleep.Through 10% glycerol, the soft cream of Strong etc. is smeared treatment and Chinese medicine for oral administration is not healed repeatly.Through this health-care lotion Saunas, every other day once, continuous five times, skin pruritus is removed, and falls asleep steadily.Not recurrence in nine months.
Claims (10)
1. the compositions for health bath, described compositions comprises Chinese medicine astragalus decoction pieces component and Ramulus et folium taxi cuspidatae micronized particle component, the weight ratio of Ramulus et folium taxi cuspidatae micronized particle component and Chinese medicine astragalus decoction pieces is 50:10 ~ 150, described Ramulus et folium taxi cuspidatae micronized particle is by being that Taxus peel of stem and/or root below 4.0 % by weight mixes according to the weight ratio of 100:10 ~ 40 with solid-state micronization auxiliary agent by drying to moisture, form solid mixt, then described solid mixt is carried out to micronization pulverizing, make particle diameter D (90) be less than or equal to 15 microns and obtain granulate mixture.
2. compositions according to claim 1, wherein, the weight ratio of Ramulus et folium taxi cuspidatae micronized particle component and Chinese medicine astragalus decoction pieces is 50:40 ~ 60.
3. compositions according to claim 1 and 2, wherein, the weight ratio of Taxus peel of stem and/or root and solid-state micronization auxiliary agent is 100:15 ~ 25.
4. compositions according to claim 1, wherein, described Ramulus et folium taxi cuspidatae is any one or the two or more mixture in Chinese Ramulus et folium taxi cuspidatae, Ramulus et folium taxi cuspidatae, T. yunnanensis, Xizang Taxus chinensis, Taxus mairei; And/or wherein solid-state micronization auxiliary agent is selected from one or more in Sal, silicon dioxide, medicinal Pulvis Talci.
5. compositions according to claim 1 and 2, wherein, the weight ratio 100 of Ramulus et folium taxi cuspidatae peel of stem and root: 50-100:200.
6. compositions according to claim 1 and 2, wherein with respect to 100 weight portion Taxus peel of stem and/or roots, micronization auxiliary agent is 5 ~ 20 weight portion Sal and 5 ~ 20 weight portion medicinal Pulvis Talci.
7. compositions according to claim 1 and 2, wherein the moisture of solid-state micronization auxiliary agent is below 5.0 quality %.
8. compositions according to claim 1 and 2, wherein micronization is pulverized by any one in comminution by gas stream, ball-milling method, ultrasonic method, spray drying method and is undertaken.
9. the method for the compositions of preparation claim 1, it comprises:
(1) be that Taxus peel of stem and/or root below 4.0 % by weight mixes according to the weight ratio of 100:10 ~ 40 with solid-state micronization auxiliary agent by drying to moisture, form solid mixt, then described solid mixt is carried out to micronization pulverizing, make particle diameter D (90) be less than or equal to 15 microns;
(2) Ramulus et folium taxi cuspidatae peel of stem step (1) being obtained and/or the micronized particle of root carry out compound membrane bag packing, 50 grams every bag;
(3), by the Radix Astragali prepared slices of Chinese crude drugs, carry out compound membrane bag packing, 10 ~ 150 grams every bag;
(4) by two bags of ingredients compounds of step (2) and (3).
10. the method for the compositions of preparation claim 1, it comprises: by the lixiviate 5 minutes ~ 1 hour under lixiviate at normal temperatures 10 ~ 24 hours or the state of boiling in water or in ethanol water together with Radix Astragali decoction pieces of the micronized particle of Ramulus et folium taxi cuspidatae peel of stem claimed in claim 1 and/or root, isolate again liquid, optionally concentrated packing afterwards, obtaining for the fluid composition of health bath, is wherein the micronized particle of Ramulus et folium taxi cuspidatae peel of stem and/or root and the dry weight of Radix Astragali decoction pieces 5 times ~ 12 times for the water of lixiviate or the amount of ethanol water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310154597.0A CN103202865B (en) | 2013-04-28 | 2013-04-28 | Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310154597.0A CN103202865B (en) | 2013-04-28 | 2013-04-28 | Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103202865A CN103202865A (en) | 2013-07-17 |
| CN103202865B true CN103202865B (en) | 2014-07-09 |
Family
ID=48750419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310154597.0A Expired - Fee Related CN103202865B (en) | 2013-04-28 | 2013-04-28 | Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103202865B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585200A (en) * | 2013-09-26 | 2014-02-19 | 陈益飞 | Foot bath powder |
| CN103479685A (en) * | 2013-09-26 | 2014-01-01 | 陈益飞 | Foot bath lotion |
| CN104587509A (en) * | 2014-02-19 | 2015-05-06 | 朱乃根 | Compound taxus chinensis drug multifunction baking basket |
| CN108815208A (en) * | 2018-04-02 | 2018-11-16 | 孙向勇 | Health care fermentation wood powder |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101837029A (en) * | 2009-03-19 | 2010-09-22 | 粟时献 | Nanometer taxus chinensis powder and preparation method thereof |
| CN102641308A (en) * | 2012-05-16 | 2012-08-22 | 江苏红豆杉生物科技有限公司 | Taxus chinensis var mairei Chinese herbal material as well as processing method and application thereof |
-
2013
- 2013-04-28 CN CN201310154597.0A patent/CN103202865B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN103202865A (en) | 2013-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100353983C (en) | Chinese medicine preparation for reducing sugar | |
| CN101239112B (en) | Chinese medicinal composition for regulating blood fat and preparation thereof | |
| CN105169118A (en) | Dendrobium officinale compound health buccal tablet and preparation method thereof | |
| CN103202865B (en) | Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof | |
| CN102579836B (en) | Traditional Chinese medical dendrobium huoshanense composition and preparation method thereof | |
| CN102614281B (en) | Chinese medicinal composition for improving anoxia endurance and preparation method and application thereof | |
| CN105232584A (en) | Decoction-free extraction process for precious Chinese herbal medicines | |
| CN105266149A (en) | Herba dendrodii officinalis compound health-care capsule and preparation method thereof | |
| CN102210638A (en) | Nano Taxus chinensis var.mairei fruit health-care massage oil and manufacturing method thereof | |
| CN106107294A (en) | A kind of compound recipe plateau hippophae rhamnoides beverage and preparation method thereof | |
| CN102846753A (en) | Preparation process of integration-type novel formulation of Radix Puerariae, Rhizoma Coptidis and Scutellaria baicalensis decoction and production method thereof | |
| CN103083522B (en) | Traditional Chinese medicine composition for hair growing and hair nourishing, as well as preparation method and application thereof | |
| CN104288601A (en) | Skin itching-relieving ointment and preparation method thereof | |
| CN102293931B (en) | Traditional Chinese medicinal composition, clinical preparation and preparation methods thereof | |
| CN102000172A (en) | Oral liquid, granules and powder for preventing and treating chronic allergic rhinitis | |
| CN101352520B (en) | Sperm-nourishing capsules for treating male sexual disfunction and preparation method thereof | |
| CN104474195A (en) | Traditional Chinese medicine compound preparation for treating leucoderma and preparation method of traditional Chinese medicine compound preparation | |
| CN101991806A (en) | Miscarriage prevention liquid and capsule | |
| CN105148240A (en) | Medicinal preparation used for treating chronic cardiac failure | |
| CN106188083B (en) | A method of extracting 1, 8-Cineole volatile oil from folium artemisiae argyi | |
| CN104721508A (en) | Pharmaceutical composition for treating upper respiratory infection and preparation method thereof | |
| CN104289294A (en) | Traditional Chinese medicine production method | |
| CN107823042A (en) | Natural plants weight-reducing health-care nanometer frost | |
| WO2015018123A1 (en) | Traditional chinese medicine preparation for reducing blood sugar and preparation method thereof | |
| CN102247441A (en) | Traditional Chinese medicine external washing powder and effervescent tablet for preventing cold, and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140709 Termination date: 20180428 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |