CN106176855B - A kind of concocting method of red ginseng medicine materical crude slice - Google Patents
A kind of concocting method of red ginseng medicine materical crude slice Download PDFInfo
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- CN106176855B CN106176855B CN201610528689.4A CN201610528689A CN106176855B CN 106176855 B CN106176855 B CN 106176855B CN 201610528689 A CN201610528689 A CN 201610528689A CN 106176855 B CN106176855 B CN 106176855B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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Abstract
The invention discloses a kind of concocting methods of red ginseng medicine materical crude slice, it is characterised in that the method are as follows: cleans scarlet ginseng, drains, then slice or dissection；30-90min is steamed under 105-130 DEG C of saturated steam conditions again, quick pressure releasing is to normal pressure after steaming, and vacuum drying immediately, obtains red ginseng medicine materical crude slice；The present invention steams the microbial load that can significantly reduce red ginseng medicine materical crude slice to be saturated, or even obtains sterile grade medicine materical crude slice, and the medical support for improving medicinal material is horizontal；It steams, dry, packaging integrated completion, material need not be transported repeatedly, reduce unnecessary carrying waste, also reduce secondary pollution risk；It steams and is greatly shortened with drying time, reduce 50% or more compared with conventional method time-consuming；With ginsenoside Rg3It is 3~5 times high for the more traditional concocting method of rare saponin content of representative.
Description
(1) technical field
It is the present invention relates to a kind of Chinese medicine Preparation process method, in particular to a kind of by red ginseng (fresh) Chinese medicine Processing methods
At the method for red ginseng medicine materical crude slice.
(2) background technique
Red ginseng be dry root of the cultivation product of Araliaceae ginseng Panaxgingseng C.A.Mey. after processing and
Rhizome has the effect of reinforcing vital energy, veins takes off admittedly, nourishing qi to stop.By traditional processing procedure, fresh ginseng steams number through vapor
Hour, then through heated-air drying up to red ginseng.To ensure patient medication safety, red ginseng is as medical medicine materical crude slice and with crude drug fecula
When form is used as medicine, it is both needed to control microbial load." drug GMP certification inspection evaluation criteria " the 7023rd article of regulation: " directly it is used as medicine
Medicinal powder, microorganism checking should be done before ingredient ", Chinese drugs powder meets microbial limit requesting party and can be used as medicine." middle traditional Chinese medicines
Allusion quotation " the oral preparation of Chinese traditional medicinal microbial limits of regulation original powder containing medicinal material of 2015 years versions is that aerobic bacteria sum is not higher than 104cfu/
G, yeast and mold sum are not higher than 102Cfu/g, while control bacterium must not be detected.In view of the potential microorganism of production process
The microbial load of the risk of pollution, Chinese medicine material medicinal powder should at least reduce an order of magnitude.However, current red ginseng medicinal material
In drying, packaging, storage and transportational process, material transports machining tool and operating environment is difficult to effectively by repeatedly transfer
Control, in addition red ginseng medicinal material is rich in nutrition, microbiological pollution is serious.For medical medicine materical crude slice and medicinal material fecula is processed as in cutting
Before, it generally requires to carry out two-stage sterilization processing, not only time-consuming energy consumption, and will lead to active ingredient loss.
In addition, through processing after red ginseng chemical composition significant changes have occurred, the particularly important is produce it is some peculiar
Ingredient, such as ginsenoside Rg3、Rh2, maltol etc..Scientific research proves ginsenoside Rg3With unique bioactivity, have anti-
Tumour increases and anti-transferance, and has good action in terms of cardiovascular and nervous system protection, it is considered to be the weight of red ginseng
Want effective component.However, the red ginseng processed in the conventional way, Rg3Content 3/10000ths hereinafter, referred to as rare saponin(e.
In red ginseng processing procedure and method field, Zhao Fanglin etc. discloses a kind of increase ginseng or American Ginseng by acid adding enhanced hydrolysis
Ginsenoside Rg3Method (CN101278954), leaf just good etc. disclose a kind of increase by raw material, addition acetic acid of sun-dried ginseng
Ginsenoside Rg in red ginseng3The method of content.But such methods external source in ginseng adds bronsted lowry acids and bases bronsted lowry, can cause to red ginseng quality
Unknown influence.Jin Feng change et al. discloses a kind of utilization endogenous enzymes promotion ginsenoside conversion, and obtains the side of high activity red ginseng
Method (CN100423732C).Yu Shengjun etc. discloses a kind of utilization microbial fermentation promotion Rg3The increased fermented red ginseng of content
Preparation method (CN104784230A).The red ginseng manufacturer that Hong Xidao etc. discloses a kind of high temperature high pressure process and is dried under reduced pressure
Method its main feature is that the round intact form joined can be maintained, and increases the content of total phenolic compounds, maltol and rare saponin(e
(CN103156896B), but technique is more complex, and material need to be shifted repeatedly.But it there is no a kind of red ginseng concocting method can be effective at present
Control microbial load, the method for avoiding secondary pollution, and can increase rare saponin content.
(3) summary of the invention
It is an object of the present invention to provide one kind strict control microbial load and to increase the people of rare saponin(e
(red) ginseng process of preparation method.
The technical solution adopted by the present invention is that:
The present invention provides a kind of concocting method of red ginseng medicine materical crude slice, the method are as follows: washes scarlet ginseng (or other ginsengs)
Only, drain, then slice or dissection；30-90min is steamed under 105-130 DEG C of saturated steam conditions again, after steaming quickly
Pressure release is to normal pressure, and vacuum drying immediately, obtains ginseng medicine materical crude slice.
Further, after the scarlet ginseng is cleaned, airing, air-dry or low temperature drying to mass water content 50%~70%,
In order to avoid content is excessively lost in cutting.Pre-dried red ginseng is removed into dis-medicinal part first when red ginseng cutting, is then cut
In blocks or section.According to actual needs, if as medical medicine materical crude slice, can cutting be round or subcircular piece, with a thickness of 3-5mm；If making
For Chinese patent drug raw materials for production can cutting be piece or section, thickness is no more than 20mm.It is processed and is dried after cutting, be conducive to steam
It penetrates and is evaporated with moisture, therefore process time can be greatly shortened.
Further, the slice or the thickness or length of dissection are 3-20mm.
Further, the vacuum drying, which refers to, is evacuated to -0.1~-0.08MPa, dry 5-10h.
Further, the mass water content of the vacuum drying to red ginseng medicine materical crude slice is not higher than 12%.
Further, the condition that steams is that 121 DEG C of saturated vapors steam 30min.
Further, the concocting method of the red ginseng medicine materical crude slice are as follows: after cleaning scarlet ginseng, dry under the conditions of 40 DEG C to aqueous
Amount 50%, is then sliced, with a thickness of 3~5mm；30min is steamed under 121 DEG C of saturated steam conditions again, after steaming quickly
Pressure release is evacuated to -0.085MPa to normal pressure immediately, dry to water content 6%~12%, obtains red ginseng medicine materical crude slice.
The present invention steams, drying integrated is completed, and does not during which need handling material.Being saturated steaming temperature is 105-130 DEG C, is steamed
Time processed is 30-90min, not only completes to steam processing, and can play the role of sterilization.Quick pressure releasing is extremely after steaming
Normal pressure, vacuum drying 5-10h immediately, relative degree of vacuum is maintained at -0.1~-0.08MPa in equipment.Quick pressure releasing and pumping are true
Sky can quickly reduce temperature of charge using the gasification of water, reduce active ingredient loss.According to material and equipment situation, Ke Yixuan
It selects radiation and conduction pattern provides energy.In order to improve ginseng sapoglycoside Rg 3 retention rate, can by temperature of charge control 40 DEG C with
Under.
In addition the saturated vapor described in this case steams recommendation and sterilizes in high pressure steam sterilization drier or high voltage pulse
It is carried out in drying cupboard.
After drying, material water ratio is not higher than 12%.It should complete to pack under clean protective condition and seal, it is ensured that
Medicine materical crude slice is no longer influenced by secondary pollution.The red ginseng medicine materical crude slice prepared according to the above method, aerobic bacteria sum is 103Cfu/g hereinafter, mould and
Yeast sum is in 10cfu/g hereinafter, even can satisfy sterile medicine materical crude slice requirement.The total amount of ginsenoside Re and Rg1 are not less than
0.5%, ginsenoside Rb1's content is not less than 0.3%, and ginseng sapoglycoside Rg 3 content is close to 0.1%.
Advantage of the invention includes:
1. steaming the microbial load that can significantly reduce red ginseng medicine materical crude slice to be saturated, or even sterile grade medicine materical crude slice is obtained, improved
The medical support of medicinal material is horizontal；
2. steaming, drying, packaging integrated completion, material need not be transported repeatedly, reduce unnecessary carrying waste,
Reduce secondary pollution risk；
It is greatly shortened 3. steaming with drying time, reduces 50% or more compared with conventional method time-consuming；
4. with ginsenoside Rg3It is 3~5 times high for the more traditional concocting method of rare saponin content of representative.
(4) specific embodiment
The present invention is described further combined with specific embodiments below, but protection scope of the present invention is not limited in
This:
Embodiment 1:
The commercially available 5 years fresh each 1000g of red ginseng in Jilin Ji'an are taken, A group (by traditional concocting method) and (the high pressure steaming of B group are divided into
System vacuum drying).
A group red ginseng drains after cleaning to epidermis noresidue water, and water proof steams 3h, is then transferred to convection oven, at 50 DEG C
Under the conditions of dry 72h, soften rear shave to get medicine materical crude slice A.
B group red ginseng drains after cleaning to epidermis noresidue water, is transferred to convection oven, predrying 2h under the conditions of 40 DEG C, medicine
Then material mass water content about 55% cuts into the similar round piece of about 5mm, be transferred to YXQ-LS-50G high pressure steam sterilization drier
(external water ring vacuum pump) rises to 121 DEG C (saturated vapors) to temperature, keeps 30min, is then deflated to normal pressure immediately, then
It vacuumizes, heating temperature is set as 35 DEG C, and relative degree of vacuum maintains -0.085MPa or so, dry for 24 hours up to medicine materical crude slice B.
Above-mentioned medicine materical crude slice is closed with sterilized sampling bag under clean protective condition, and stores at 4 DEG C.
Prepared slice quality moisture content is measured with dry weight-loss method, A group is that 10.2%, B group is 10.8%.
Piece A and each 10g of medicine materical crude slice B are drunk, the sodium chloride-peptone buffer agent for adding pH7.0 sterile to 100ml, shaking
20min.Then it takes supernatant to dilute step by step and carries out plate culture, remaining operation is referring to " Chinese Pharmacopoeia " 2010 editions annex inspections
Survey total number of bacteria, mould and yeast sum.
Ginsenoside Re, Rg and Rb in medicine materical crude slice1Assay referring under " Chinese Pharmacopoeia " 2010 editions " ginseng " items
Regulation detection.
Ginsenoside Rg3Assay using the following method:
Sample pretreatment: drinking piece and beat powder, and accurately weighed 1g powder is set in stuffed conical flask, and volumetric concentration is added in precision
75% ethanol water 50ml, ultrasonic (300W) extract 60min, filter, and residue is merged with 75% ethyl alcohol water washing of volumetric concentration
Filtrate and cleaning solution, rotary evaporated to dryness cross 0.45 μm of filter membrane, i.e., with initial liquid phase (29% acetonitrile solution) constant volume 5ml
?.
Chromatographic condition: chromatograph Agilent 1260HPLC (400bar), chromatographic column Agilent Extend-C18
(250mm × 4.6mm, 5 μm), 30 DEG C of column temperature, flow velocity: 1ml/min, mobile phase acetonitrile (A)-pure water (B), elution requirement is shown in Table 1.
1 gradient table of table
The testing result of the different processing procedure medicine materical crude slice of table 2
Medicine materical crude slice testing result (being shown in Table 2) shows the red ginseng medicine materical crude slice prepared using present invention process, and microbial load is lower,
Ginsenoside Re, Rg1And Rb1Content meets regulation；Ginsenoside Rg3Content be 4.3 times of traditional processing group.
Embodiment 2:
The commercially available scarlet ginseng in Jilin is taken, single-row stacking is no more than 0.5m after cleaning, and (relative air humidity is low for indoor forced ventilation
In 30%), overnight, quality of medicinal material moisture content is down to about 70%, removes dis-medicinal part, then cut into the section of about 1-2cm, takes
The stacking of 100kg single layer is transferred to XGI.DMF-210B high voltage pulse sterilizing-drying cabinet (external water ring vacuum pump), is passed through saturated vapor
105 DEG C of beginning timing are risen to gas phase temperature, during which temperature fluctuation range control keeps 60min, then stand at 105~130 DEG C
It is deflated to normal pressure, is then vacuumized, heating coil temperature is set in 40~50 DEG C, relative degree of vacuum maintains -0.08~-
0.085MPa, dry 50h is up to red ginseng medicine materical crude slice.
Above-mentioned sample is through detecting, ginsenoside Re and Rg1Sum, Rb1、Rg3Content be respectively 0.43%, 0.32% He
0.078%.Total number of bacteria is lower than 100cfu/g, and mould and yeast sum are lower than 10cfu/g.
Claims (8)
1. a kind of concocting method of red ginseng medicine materical crude slice, it is characterised in that the method are as follows: clean scarlet ginseng, drain, be then sliced
Or dissection；30-90min is steamed under 105-130 DEG C of saturated steam conditions again, quick pressure releasing is existed side by side to normal pressure after steaming
That is vacuum drying obtains red ginseng medicine materical crude slice.
2. the concocting method of red ginseng medicine materical crude slice as described in claim 1, it is characterised in that after the scarlet ginseng is cleaned, airing is air-dried
Or low temperature drying to mass water content 50%~70%.
3. the concocting method of red ginseng medicine materical crude slice as described in claim 1, it is characterised in that the slice or the thickness or length of dissection
For 3-20mm.
4. the concocting method of red ginseng medicine materical crude slice as described in claim 1, it is characterised in that the vacuum drying refer to be evacuated to-
0.1~-0.08MPa, dry 5-10h.
5. the concocting method of red ginseng medicine materical crude slice as claimed in claim 4, it is characterised in that the vacuum drying to red ginseng medicine materical crude slice
Mass water content is not higher than 12%.
6. the concocting method of red ginseng medicine materical crude slice as described in claim 1, it is characterised in that the condition that steams is 121 DEG C of saturated vapors
Steam 30min.
7. the concocting method of red ginseng medicine materical crude slice as described in claim 1, it is characterised in that the method are as follows: after scarlet ginseng is cleaned,
It dries under the conditions of 40 DEG C to mass water content 50%~70%, is then sliced, with a thickness of 3~5mm；Again in 121 DEG C of saturated vapors
Under the conditions of steam 30min, quick pressure releasing is to normal pressure after steaming, and is evacuated to -0.085MPa immediately, dry to contain to quality
Water 6%~12%, i.e. acquisition red ginseng medicine materical crude slice.
8. the concocting method of red ginseng medicine materical crude slice as described in claim 1, it is characterised in that described to steam in high pressure steam sterilization drying
It is carried out in device or high voltage pulse sterilizing-drying cabinet.
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| CN109793767B (en) * | 2017-11-17 | 2021-07-16 | 牡丹江医学院 | Ginseng radix Rubri preparation process capable of increasing ginsenoside content |
| CN114191572A (en) * | 2020-09-02 | 2022-03-18 | 天士力医药集团股份有限公司 | Sterilizing method of yippee sansheng medicinal material oral powder |
| CN114869925A (en) * | 2022-04-29 | 2022-08-09 | 中国药科大学 | Ginseng radix Rubri processing method for increasing content of rare saponins in Ginseng radix |
| CN116196344B (en) * | 2023-03-13 | 2024-02-13 | 重庆市急救医疗中心(重庆市第四人民医院、重庆市急救医学研究所) | Preparation method of red ginseng decoction pieces |
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