CN103948641A - Drying method of Cordyceps - Google Patents
Drying method of Cordyceps Download PDFInfo
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- CN103948641A CN103948641A CN201410204824.0A CN201410204824A CN103948641A CN 103948641 A CN103948641 A CN 103948641A CN 201410204824 A CN201410204824 A CN 201410204824A CN 103948641 A CN103948641 A CN 103948641A
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Abstract
The invention relates to a drying method of Cordyceps, which comprises the following steps: taking newly dug fresh Cordyceps, stacking for 2-5 days and drying. The prepared Cordyceps has high content of main effective components, is used for auxiliary treatment of cancers and immunity enhancement, and has favorable clinical curative effect.
Description
Invention field
The present invention relates to medicine preparation method, particularly a kind of drying means of Cordyceps, belongs to medical technical field.
Background technology
Cordyceps is that section ergot fungus cordyceps sinensis bacterium colonizes in Stroma on Hepialidae insect larvae and the dry composite body of larva corpse.Early summer Stroma is unearthed, spore does not take while dispersing, and shines to 6 seventy percent dry, removes quasi-fibrous attachment and impurity, dries or cold drying.Cordyceps is a kind of rare Chinese medicine of China, classifies China's three large tonics together with Radix Ginseng, Cornu Cervi Pantotrichum as, have the title of soft gold.Cordyceps enters lung, kidney channel, can the kidney invigorating lung benefiting, and hemostasis and phlegm, has immunomodulating, antitumor, protection Liver and kidney and calmness, antifatigue effect.Cordyceps contains various active material, comprise ucleosides, polysaccharide, amino acid polypeptide class and various trace elements, wherein nucleosides material is main active, in nucleoside, with adenosine, there is obvious pharmacological action again, so working standard is using adenosine content as the leading indicator of investigating Cordyceps quality.
Li Shao equality, content and variation (Li Shao equality at Cordyceps Nucleosides, content and the variation of natural and fermentation culture Cordyceps Nucleosides, Acta Pharmaceutica Sinica, the 36th the 6th phase of volume of calendar year 2001,436-439 page) in research, show that in the Cordyceps of fresh collection, adenosine class content of material is extremely low, and gather with the passing of time, person's gradient elution content is higher, prompting natural cordyceps Nucleosides may derive from the degraded of macromole nucleoside in storage process, and result of study shows the damp and hot content that increases nucleosides material in Cordyceps.
Summary of the invention
The drying means that the object of this invention is to provide a kind of Cordyceps, the dry active ingredients of cordyceps sinensis ucleosides content of the method is high, and for auxiliary treatment and the enhancing immunity of cancer, clinical efficacy is good.
The present invention is achieved in that
A drying means for Cordyceps, is characterized in that: the fresh Cordyceps newly digging out, the 2-5 days that banks up is dry.
The drying means of a kind of Cordyceps of the present invention, is characterized in that: dry is that heap postpone is dried or dries or oven dry or lyophilizing.
The drying means of Cordyceps of the present invention, has same effect for the Cordyceps fungus powder that ferments.
Above-mentioned fermentation Cordyceps fungus powder refers to from Cordyceps what separated strain was prepared by the method for industrial fermentation, as hundred raw materials that make capsule, JINSHUIBAO, Cordyceps militaris (L.) Link. sheet.
So far completed the present invention, the active ingredients of cordyceps sinensis content of preparing by drying means of the present invention is high, and for auxiliary treatment and the enhancing immunity of cancer, clinical efficacy is good.
Test example is intended to further illustrate substantive progress of the present invention below, but not limitation of the present invention.
The active constituent content comparative test of Cordyceps of the present invention and common Cordyceps and Cordyceps nano powder
1, instrument and material
The semi-automatic digestion instrument of Switzerland SOTAX; Waters high performance liquid chromatograph.Adenosine reference substance is purchased from Nat'l Pharmaceutical & Biological Products Control Institute, for assay.
Cordyceps: be purchased from Jinan Bai Weitang decoction pieces factory, decoction pieces is up to the standards through hundred taste halls.
Cordyceps nano powder: be purchased from Jinan Bai Weitang decoction pieces factory Cordyceps decoction pieces, pulverize, cross 325 mesh sieves.
Cordyceps 1: get the fresh Cordyceps coming from place of production air transport, bank up 3 days at dark and damp place, 50 ℃ of following oven dry.
2, Determination of Adenosine: measure according to method under 2010 editions (one) Cordyceps items of < < Chinese Pharmacopoeia > >.
Chromatographic condition and system suitability be take octadecylsilane chemically bonded silica as filling chaste tree; Phosphate buffer (the pH6.5)-methanol (85:15) of take is mobile phase; Detection wavelength is 260nm.Number of theoretical plate calculates and should be not less than 2000 by adenosine peak.
It is appropriate that adenosine reference substance is got in the preparation of reference substance solution, accurately weighed, adds 90% methanol and make every 1m1 containing the solution of 20 μ g, obtains.
The preparation of need testing solution is got respectively Cordyceps (pulverizing sieve No. three), Cordyceps nano powder, worm summer in winter 1(and was pulverized sieve No. three) each about 0.5g, accurately weighed, put in tool plug conical flask, precision adds 90% methanol 10ml, and close plug, shakes up, weighed weight, reflux 30 minutes, lets cool, weighed weight again, the weight of supplying less loss with 90% methanol, shakes up, and filters, get subsequent filtrate, obtain.Algoscopy is accurate reference substance solution and each l0 μ l of need testing solution of drawing respectively, and injection liquid chromatography, measures, and obtains.
Result: in dry product, three kinds of Cordyceps sample adenosine contents are in Table 1.
Three kinds of Cordyceps sample adenosine contents of table 1 (%)
| Decoction pieces | Cordyceps decoction pieces | Cordyceps nano powder | Cordyceps decoction pieces 1 |
| Adenosine content | 0.0278 | 0.0304 | 0.0501 |
Presentation of results, the Cordyceps of preparing by method of the present invention, active constituent content is obviously high, good product quality.
The specific embodiment
embodiment 1
Get the fresh Cordyceps newly digging out, at dark and damp place, bank up 2 days, dry.
embodiment 2
Get the fresh Cordyceps newly digging out, bank up in the cool 3 days, dry.
embodiment 3
Get the fresh Cordyceps newly digging out, at dark and damp place, bank up 5 days, put in freeze dryer, solidification point is controlled at-30 ℃; Reach and control after temperature, open immediately vacuum pump and be evacuated to below drying chamber pressure 50Pa, then start heater switch, promote distillation, the temperature of distillation should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃, to dry.
embodiment 4
Get the Hirsutlla sinensis mycelium of the new tank that ferments, bank up in the cool 4 days, dry.
embodiment 5
Get the Paecilomyces hepiali Chen et Dai Mycelia of the new tank that ferments, at dark and damp place, bank up 3 days, dry.
embodiment 6
Get the cordyceps mycelium of the new tank that ferments, at dark and damp place, bank up 4 days, dry.
Claims (3)
1. a drying means for Cordyceps, is characterized in that: get the Cordyceps of newly gathering, the 2-5 days that banks up at dark and damp place, is dried.
2. according to the drying means of a kind of Cordyceps of claim 1, it is characterized in that: dry is that heap postpone is dried or dries or oven dry or lyophilizing.
3. according to the drying means of a kind of Cordyceps of claim 1, it is characterized in that: for the Cordyceps fungus powder that ferments, have same effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410204824.0A CN103948641A (en) | 2014-05-15 | 2014-05-15 | Drying method of Cordyceps |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410204824.0A CN103948641A (en) | 2014-05-15 | 2014-05-15 | Drying method of Cordyceps |
Publications (1)
| Publication Number | Publication Date |
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| CN103948641A true CN103948641A (en) | 2014-07-30 |
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| CN201410204824.0A Pending CN103948641A (en) | 2014-05-15 | 2014-05-15 | Drying method of Cordyceps |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104154712A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Drying method of lamiophlomis rotata |
| CN104154717A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Drying method of high-activity lamiophlomis rotata |
-
2014
- 2014-05-15 CN CN201410204824.0A patent/CN103948641A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 冬虫夏草研究课题组: "冬虫夏草的加工与产业可持续发展", 《保鲜与加工》 * |
| 李绍平等: "天然与发酵培养冬虫夏草中核苷类成分的含量及其变化", 《药学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104154712A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Drying method of lamiophlomis rotata |
| CN104154717A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Drying method of high-activity lamiophlomis rotata |
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Application publication date: 20140730 |