CN101933971B - Oral liquid of honeysuckle flower and baical skullcap root and preparation method thereof - Google Patents
Oral liquid of honeysuckle flower and baical skullcap root and preparation method thereof Download PDFInfo
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Abstract
The invention discloses oral liquid of honeysuckle flower and baical skullcap root and a preparation method thereof. The medicament consists of honeysuckle flower extract and baical skullcap root extract, and is characterized in that every 1ml of solution comprises no less than 18.0mg of baical skullcap root extract based on the amount of baicalin and no less than 3.0mg of honeysuckle flower extract based on the total amount of chlorogenic acid and 4-O-caffeoylquinic acid, wherein the proportion of the chlorogenic acid to the 4-O-caffeoylquinic acid is 5:4-2:1; and the PH value of the solution is 5.5 to 5.9. The medicament has the advantage of more stable quality.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly a kind of YINHUANG KOUFUYE and preparation method thereof.
Background technology
YINHUANG KOUFUYE records in 2010 editions one one of the Pharmacopoeia of the People's Republic of China, and its main component is Flos Lonicerae extract and Radix Scutellariae extract, and its production technology is: get Radix Scutellariae extract and add water and make dissolving in right amount, regulate pH value to 8 with 8% sodium hydroxide solution; Filter, filtrating merges with Flos Lonicerae extract, regulates pH value to 7.2 with 8% sodium hydroxide solution, boils 1 hour; Filter, the adding simple syrup is an amount of, adds water to nearly full dose, stirs; Regulate pH value to 7.2 with 8% sodium hydroxide solution, add water to 1000ml, filter; Embedding, sterilization promptly gets.This product has the effect of cleaning heat and expelling wind, liyan jiedu, is used for dry pharynx, pharyngalgia, pharyngeal tonsils enlargement, thirsty, heating due to affection due to external wind and heat, the exuberant lung-stomach heat; Acute and chronic tonsillitis, acute/chronic pharyngitis, upper respiratory tract infection are seen above-mentioned patient.This product determined curative effect, rapid, the taking convenience of effect are welcome by extensive patients deeply.But also there is following deficiency in this product: (1) sample sterilization process, pH value descend more than 1.0, and chlorogenic acid content descends and surpasses 30%; (2) along with the prolongation of standing time, the pH value of medicinal liquid reduces sample gradually in storage process, and medicinal liquid color, clarity are changed, and influences product quality; (3) chlorogenic acid is prone to take place hydrolysis and ester group migration isomerization in the sample solution in storage process, and it is fast to cause content to descend.
Summary of the invention
The object of the present invention is to provide a kind of YINHUANG KOUFUYE and preparation method thereof, method for preparing of the present invention is more scientific and reasonable, and drug quality is more stable.
YINHUANG KOUFUYE provided by the invention, it is made up of Flos Lonicerae extract and Radix Scutellariae extract, and its preparation method is following:
It is an amount of to get Radix Scutellariae extract, adds water and makes dissolving, regulates pH value to 8 with 8% sodium hydroxide solution, filters filtrate for later use; The extracting honeysuckle extract is an amount of in addition, regulates pH value to 6.0～7.0 with 8% sodium hydroxide solution, puts in 70～100 ℃ of water-baths and heats 15 ~ 60min, and cooling filters filtrate for later use; Above-mentioned filtrating is merged, and the adding simple syrup is an amount of, adds water to nearly full dose, stirs, and regulates pH value to 5.6 ~ 6.2, adds water to 1000ml, filter, and embedding, sterilization promptly gets;
The every 1ml of these article contains Radix Scutellariae extract in baicalin, must not be less than 18.0mg; The every 1ml of these article contains the total amount of Flos Lonicerae extract in chlorogenic acid and 4-O-caffeoyl guinic acid, must not be less than 3.0mg, and ratio is 5:4 ~ 2:1 between chlorogenic acid and the 4-O-caffeoyl guinic acid; These article pH value is 5.5 ~ 5.9.
YINHUANG KOUFUYE provided by the invention, it is made up of Flos Lonicerae extract and Radix Scutellariae extract, and its preparation method is following:
It is an amount of to get Radix Scutellariae extract, adds water and makes dissolving, regulates pH value to 8 with 8% sodium hydroxide solution, filters filtrate for later use; The extracting honeysuckle extract is an amount of in addition, regulates pH value to 6.0～7.0 with 8% sodium hydroxide solution, puts in 70～100 ℃ of water-baths and heats 15 ~ 60min; Cooling; Filter, filtrating adds 0.05% ~ 0.1%EDTA and/or 0.01% ~ 1.0% PH stabilizing agent and/or 0.1% ~ 0.5% sodium sulfite, and is subsequent use; Above-mentioned filtrating is merged, and the adding simple syrup is an amount of, adds water to nearly full dose, stirs, and regulates pH value to 5.6 ~ 6.2, adds water to 1000ml, filter, and embedding, sterilization promptly gets;
The every 1ml of these article contains Radix Scutellariae extract in baicalin, must not be less than 18.0mg; The every 1ml of these article contains the total amount of Flos Lonicerae extract in chlorogenic acid and 4-O-caffeoyl guinic acid, must not be less than 3.0mg, and ratio is 5:4 ~ 2:1 between chlorogenic acid and the 4-O-caffeoyl guinic acid; These article pH value is 5.5 ~ 5.9.
The method for preparing of said Flos Lonicerae extract is: extracting honeysuckle, add 15% alcohol reflux secondary, and each each 1 hour, merge extractive liquid; Being evaporated to relative density is the clear paste of 1.15 ~ 1.18 (60 ℃), adds ethanol and makes and contain alcohol amount and reach 65%, leaves standstill 24 hours, gets supernatant; Being evaporated to relative density is 1.20 ~ 1.24 (60 ℃), adds water to 750g, airtight; Cold preservation was got supernatant more than 24 hours, promptly got.
The method for preparing of said Radix Scutellariae extract is: get Radix Scutellariae, the decocte with water secondary each 1.5 hours, filters collecting decoction; Filtrating is concentrated into an amount of (with the ratio 10:1 of medical material amount), regulates pH value to 1.8 ~ 2.0,60 ℃ insulation 30 minutes with the 2mol/L hydrochloric acid solution, is cooled to room temperature; Placed 12 hours, and filtered, deposition is washed till pH value to 4.0 with ethanol, adds 10 times of water gagings and stirs; With 20% sodium hydroxide solution adjust pH to 7.0, add equivalent ethanol after the dissolving and stir, placed 12 hours, filter; Filtrating is regulated pH value to 1.8 ~ 2.0,80 ℃ insulation 30 minutes with the 2mol/L hydrochloric acid solution, is cooled to room temperature, filters; Deposition is washed till pH value to 4.0 with ethanol, and drying under reduced pressure is ground into fine powder, promptly gets.
Said PH stabilizing agent is sodium citrate, citric acid, phosphate or sulfate.
The present invention innovates part and is: find through experimental study; Earlier Flos Lonicerae extract is heated a period of time under weak basic condition; Make chlorogenic acid and 4-O-caffeoyl guinic acid amount be in certain proportion; And, not only improved chlorogenic acid contents in the preparation greatly, and preparation is more stable in storage process through controlling the pH value of sterilization front and back solution.
The specific embodiment
Following embodiment is used to explain the present invention, but is not used for limiting scope of the present invention.
Embodiment 1
Flos Lonicerae extract (in chlorogenic acid) 2.4g
Radix Scutellariae extract (in baicalin) 24g
Above-mentioned raw materials is processed 1000ml as follows;
Get Radix Scutellariae extract, add water and make dissolving in right amount, regulate pH value to 8, filter filtrate for later use with 8% sodium hydroxide solution; The extracting honeysuckle extract is regulated pH value to 6.2 with 8% sodium hydroxide solution in addition, puts in 80 ℃ of water-baths and heats 60min, and cooling filters filtrate for later use; Above-mentioned filtrating is merged, and the adding simple syrup is an amount of, adds water to nearly full dose, stirs, and regulates pH value to 6.0, adds water to 1000ml, filter, and embedding, sterilization promptly gets;
The method for preparing of Flos Lonicerae extract is: extracting honeysuckle, add 15% alcohol reflux secondary, and each each 1 hour, merge extractive liquid; Being evaporated to relative density is the clear paste of 1.15 ~ 1.18 (60 ℃), adds ethanol and makes and contain alcohol amount and reach 65%, leaves standstill 24 hours, gets supernatant; Being evaporated to relative density is 1.20 ~ 1.24 (60 ℃), adds water to 750g, airtight; Cold preservation was got supernatant more than 24 hours, promptly got;
The method for preparing of Radix Scutellariae extract is: get Radix Scutellariae, the decocte with water secondary each 1.5 hours, filters collecting decoction; Filtrating is concentrated into an amount of (with the ratio 10:1 of medical material amount), regulates pH value to 1.8 ~ 2.0,60 ℃ insulation 30 minutes with the 2mol/L hydrochloric acid solution, is cooled to room temperature; Placed 12 hours, and filtered, deposition is washed till pH value to 4.0 with ethanol, adds 10 times of water gagings and stirs; With 20% sodium hydroxide solution adjust pH to 7.0, add equivalent ethanol after the dissolving and stir, placed 12 hours, filter; Filtrating is regulated pH value to 1.8 ~ 2.0,80 ℃ insulation 30 minutes with the 2mol/L hydrochloric acid solution, is cooled to room temperature, filters; Deposition is washed till pH value to 4.0 with ethanol, and drying under reduced pressure is ground into fine powder, promptly gets.
Embodiment 2
Flos Lonicerae extract (in chlorogenic acid) 2.4g
Radix Scutellariae extract (in baicalin) 24g
Above-mentioned raw materials is processed 1000ml as follows;
Get Radix Scutellariae extract, add water and make dissolving in right amount, regulate pH value to 8, filter filtrate for later use with 8% sodium hydroxide solution; The extracting honeysuckle extract is regulated pH value to 7.0 with 8% sodium hydroxide solution in addition, puts in 70 ℃ of water-baths and heats 30min, and cooling filters, and filtrating adds the 2g sodium sulfite, and is subsequent use; Above-mentioned filtrating is merged, and the adding simple syrup is an amount of, adds water to nearly full dose, stirs, and regulates pH value to 6.2, adds water to 1000ml, filter, and embedding, sterilization promptly gets.
Embodiment 3
Flos Lonicerae extract (in chlorogenic acid) 2.4g
Radix Scutellariae extract (in baicalin) 24g
Above-mentioned raw materials is processed 1000ml as follows;
Get Radix Scutellariae extract, add water and make dissolving in right amount, regulate pH value to 8, filter filtrate for later use with 8% sodium hydroxide solution; The extracting honeysuckle extract is regulated pH value to 6.5 with 8% sodium hydroxide solution in addition, puts in 100 ℃ of water-baths and heats 15min, and cooling filters, and filtrating adds 0.5g sodium citrate and 0.5g citric acid, and is subsequent use; Above-mentioned filtrating is merged, and the adding simple syrup is an amount of, adds water to nearly full dose, stirs, and regulates pH value to 5.7, adds water to 1000ml, filter, and embedding, sterilization promptly gets.
Embodiment 4
Flos Lonicerae extract (in chlorogenic acid) 2.4g
Radix Scutellariae extract (in baicalin) 24g
Above-mentioned raw materials is processed 1000ml as follows;
Get Radix Scutellariae extract, add water and make dissolving in right amount, regulate pH value to 8, filter filtrate for later use with 8% sodium hydroxide solution; The extracting honeysuckle extract is regulated pH value to 6.8 with 8% sodium hydroxide solution in addition, puts in 80 ℃ of water-baths and heats 20min, and cooling filters, and filtrating adds 0.5gEDTA, 5g sodium citrate and 5g citric acid, and is subsequent use; Above-mentioned filtrating is merged, and the adding simple syrup is an amount of, adds water to nearly full dose, stirs, and regulates pH value to 5.8, adds water to 1000ml, filter, and embedding, sterilization promptly gets.
Embodiment 5
Flos Lonicerae extract (in chlorogenic acid) 2.4g
Radix Scutellariae extract (in baicalin) 24g
Above-mentioned raw materials is processed 1000ml as follows;
Get Radix Scutellariae extract, add water and make dissolving in right amount, regulate pH value to 8, filter filtrate for later use with 8% sodium hydroxide solution; The extracting honeysuckle extract is regulated pH value to 6.0 with 8% sodium hydroxide solution in addition, puts in 100 ℃ of water-baths and heats 60min, and cooling filters, and filtrating adds 2g sodium sulfite, 0.5gEDTA, 0.5g sodium citrate and 0.5g citric acid, and is subsequent use; Above-mentioned filtrating is merged, and the adding simple syrup is an amount of, adds water to nearly full dose, stirs, and regulates pH value to 5.6, adds water to 1000ml, filter, and embedding, sterilization promptly gets.
Comparative Examples 1
Flos Lonicerae extract (in chlorogenic acid) 2.4g
Radix Scutellariae extract (in baicalin) 24g
Above-mentioned raw materials is processed 1000ml as follows;
Get Radix Scutellariae extract and add water and make dissolving in right amount, regulate pH value to 8 with 8% sodium hydroxide solution, filter, filtrating merges with Flos Lonicerae extract; Regulate pH value to 7.2 with 8% sodium hydroxide solution, boiled 1 hour, filter, the adding simple syrup is an amount of; Add water to nearly full dose, stir, regulate pH value to 7.2, add water to 1000ml with 8% sodium hydroxide solution; Filter, embedding, sterilization promptly gets.
Experimental example 1: sample detection
Carrying out each item index according to the detection method of an appendix of Pharmacopoeia of the People's Republic of China version in 2010 detects.Wherein:
The content assaying method of chlorogenic acid and 4-O-caffeoyl guinic acid is following:
Chromatographic condition and system suitability test are filler with the octadecylsilane chemically bonded silica; With acetonitrile-0.4% phosphoric acid solution (10:90) is mobile phase; The detection wavelength is 327nm.Number of theoretical plate calculates by the chlorogenic acid peak should be not less than 2000;
The chlorogenic acid reference substance is got in the preparation of reference substance solution, 4-O-caffeoyl guinic acid reference substance is an amount of, and accurate the title decides, and puts in the brown measuring bottle, adds 50% methanol and processes the solution that every 1ml contains chlorogenic acid 40 μ g, 4-O-caffeoyl guinic acid 25 μ g, promptly gets;
The preparation precision of need testing solution is measured these article 1ml, puts in the brown measuring bottle of 50ml, adds 50% methanol and is diluted to scale, shakes up, and filters, and gets subsequent filtrate, promptly gets;
Accurate respectively reference substance solution and each the 10 μ l of need testing solution of drawing of algoscopy inject chromatograph of liquid, measure, and promptly get;
Baicalin content assaying method following:
Chromatographic condition and system suitability test are filler with the octadecylsilane chemically bonded silica; With methanol-water-phosphoric acid (50:50:0.2) is mobile phase; The detection wavelength is 274nm.Number of theoretical plate calculates by the baicalin peak should be not less than 2500;
Baicalin reference substance 10mg is got in the preparation of reference substance solution, and accurate the title decides, and puts in the 100ml measuring bottle, adds dissolve with methanol and is diluted to scale; Shake up, precision is measured 5ml, puts in the 10ml measuring bottle; Thin up shakes up to scale, promptly gets (every 1ml contains baicalin 50 μ g);
The preparation precision of need testing solution is measured these article 1ml, puts in the 50ml measuring bottle, and thin up shakes up to scale, and precision is measured 3ml, puts in the 25ml measuring bottle, adds 50% methanol and is diluted to scale, shakes up, and filters, and gets subsequent filtrate, promptly gets;
Accurate respectively reference substance solution and each the 10 μ l of need testing solution of drawing of algoscopy inject chromatograph of liquid, measure, and promptly get;
Testing result is following:
| The sample title | Chlorogenic acid (mg/ml) | 4-O-caffeoyl guinic acid (mg/ml) | Baicalin (mg/ml) | PH value | Other index |
| Embodiment 1 | 2.4 | 1.4 | 22.6 | 5.8 | Qualified |
| Embodiment 2 | 2.5 | 1.3 | 22.7 | 5.9 | Qualified |
| Embodiment 3 | 2.3 | 1.5 | 22.7 | 5.6 | Qualified |
| Embodiment 4 | 2.4 | 1.3 | 22.6 | 5.7 | Qualified |
| Embodiment 5 | 2.6 | 1.5 | 22.8 | 5.6 | Qualified |
| Comparative Examples 1 | 1.9 | 0.7 | 21.8 | 6.0 | Qualified |
Conclusion: chlorogenic acid, 4-O-caffeoyl guinic acid, content of baicalin all are higher than Comparative Examples 1 in the embodiment 1-5 sample.
Experimental example 2: accelerated test
Sample is put under acceleration (40 ℃, the 75% humidity) condition, when placing March, June, taken out and detect, carry out study on the stability (investigation project: pH, chlorogenic acid content, 4-O-caffeoyl guinic acid content, content of baicalin).Result of the test is seen table 1 and table 2:
Table 1 quickens the result of the test in March
| The sample title | Chlorogenic acid (mg/ml) | 4-O-caffeoyl guinic acid (mg/ml) | Baicalin (mg/ml) | PH value | Conclusion |
| Embodiment 1 | 2.0 | 1.4 | 22.4 | 5.6 | Qualified |
| Embodiment 2 | 2.2 | 1.4 | 22.6 | 5.7 | Qualified |
| Embodiment 3 | 2.1 | 1.5 | 22.4 | 5.6 | Qualified |
| Embodiment 4 | 2.3 | 1.4 | 22.5 | 5.6 | Qualified |
| Embodiment 5 | 2.4 | 1.6 | 22.7 | 5.6 | Qualified |
| Comparative Examples 1 | 1.6 | 0.8 | 21.6 | 5.6 | Defective |
| The pharmacopeia regulation | Be not less than 1.7 | ? | Be not less than 18.0 | 5.5~7.0 | ? |
Table 2 quickens the result of the test in June
| The sample title | Chlorogenic acid (mg/ml) | 4-O-caffeoyl guinic acid (mg/ml) | Baicalin (mg/ml) | PH value | Conclusion |
| Embodiment 1 | 1.7 | 1.4 | 22.2 | 5.5 | Qualified |
| Embodiment 2 | 1.9 | 1.6 | 22.4 | 5.5 | Qualified |
| Embodiment 3 | 1.8 | 1.4 | 22.2 | 5.5 | Qualified |
| Embodiment 4 | 2.1 | 1.5 | 22.3 | 5.6 | Qualified |
| Embodiment 5 | 2.2 | 1.7 | 22.6 | 5.6 | Qualified |
| Comparative Examples 1 | 1.4 | 0.9 | 21.3 | 5.4 | Defective |
| The pharmacopeia regulation | Be not less than 1.7 | ? | Be not less than 18.0 | 5.5~7.0 | ? |
Conclusion: embodiment 1-5 sample quickened after 6 months; Sample each item is investigated index and is met regulation of Pharmacopoeia of the People's Republic of China version in 2010; Chlorogenic acid and 4-O-caffeoyl guinic acid total amount are not less than 3.0mg/ml; And the ratio between chlorogenic acid and the 4-O-caffeoyl guinic acid is 5:4 ~ 2:1, and the solution pH value is 5.5 ~ 5.9; Comparative Examples 1 was quickened after 3 months, and chlorogenic acid content is defective, quickens after 6 months, and chlorogenic acid and pH value are defective.
In sum, YINHUANG KOUFUYE active constituent content provided by the invention is high, and more stable quality.
Claims (5)
1. YINHUANG KOUFUYE, it is made up of Flos Lonicerae extract and Radix Scutellariae extract, it is characterized in that: every 1ml solution contains Radix Scutellariae extract in baicalin, must not be less than 18.0mg; Every 1ml solution contains the total amount of Flos Lonicerae extract in chlorogenic acid and 4-O-caffeoyl guinic acid, must not be less than 3.0mg, and ratio is 5: 4～2: 1 between chlorogenic acid and the 4-O-caffeoyl guinic acid; The solution pH value is 5.5～5.9.
2. oral liquid as claimed in claim 1; It is characterized in that: further contain 0.05%～0.1%EDTA and/or 0.01%～1.0%PH stabilizing agent and/or 0.1%～0.5% sodium sulfite, said PH stabilizing agent is sodium citrate, citric acid, phosphate or sulfate.
3. oral liquid as claimed in claim 1, its preparation method is: it is an amount of to get Radix Scutellariae extract, adds water and makes dissolving, regulates pH value to 8 with 8% sodium hydroxide solution, filters filtrate for later use; The extracting honeysuckle extract is an amount of in addition, regulates pH value to 6.0～7.0 with 8% sodium hydroxide solution, puts in 70～100 ℃ of water-baths and heats 15～60min, and cooling filters filtrate for later use; Above-mentioned filtrating is merged, and the adding simple syrup is an amount of, adds water to nearly full dose, stirs, and regulates pH value to 5.6～6.2, adds water to 1000ml, filter, and embedding, sterilization promptly gets.
4. oral liquid as claimed in claim 2, its preparation method is: it is an amount of to get Radix Scutellariae extract, adds water and makes dissolving, regulates pH value to 8 with 8% sodium hydroxide solution, filters filtrate for later use; The extracting honeysuckle extract is an amount of in addition, regulates pH value to 6.0～7.0 with 8% sodium hydroxide solution, puts in 70～100 ℃ of water-baths and heats 15～60min, and cooling filters, and filtrating adds EDTA and/or PH stabilizing agent and/or sodium sulfite, and is subsequent use; Above-mentioned filtrating is merged, and the adding simple syrup is an amount of, adds water to nearly full dose, stirs, and regulates pH value to 5.6～6.2, adds water to 1000ml, filter, and embedding, sterilization promptly gets.
5. like the arbitrary described oral liquid of claim 1-4, it is characterized in that:
The method for preparing of Flos Lonicerae extract is: extracting honeysuckle, add 15% alcohol reflux secondary, and each each 1 hour, merge extractive liquid; Relative density is 1.15～1.18 clear paste when being evaporated to 60 ℃, adds ethanol and makes and contain alcohol amount and reach 65%, leaves standstill 24 hours, gets supernatant; Relative density is 1.20～1.24 when being evaporated to 60 ℃, adds water to 750g, and is airtight; Cold preservation was got supernatant more than 24 hours, promptly got;
The method for preparing of Radix Scutellariae extract is: get Radix Scutellariae, the decocte with water secondary each 1.5 hours, filters collecting decoction; Filtrating is concentrated into and the ratio of medical material amount 10: 1, regulates pH value to 1.8～2.0,60 with the 2mol/L hydrochloric acid solution and ℃ is incubated 30 minutes, is cooled to room temperature; Placed 12 hours, and filtered, deposition is washed till pH value to 4.0 with ethanol, adds 10 times of water gagings and stirs; With 20% sodium hydroxide solution adjust pH to 7.0, add equivalent ethanol after the dissolving and stir, placed 12 hours, filter; Filtrating is regulated pH value to 1.8～2.0,80 ℃ insulation 30 minutes with the 2mol/L hydrochloric acid solution, is cooled to room temperature, filters; Deposition is washed till pH value to 4.0 with ethanol, and drying under reduced pressure is ground into fine powder, promptly gets.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1616050A (en) * | 2004-09-24 | 2005-05-18 | 鲁南制药股份有限公司 | Yinhuang oral liquor and its producing process |
| CN1660347A (en) * | 2004-01-14 | 2005-08-31 | 山东绿叶制药股份有限公司 | Yinhuang combination, oral taking preparation and injection preparation, preparing method and application |
| CN101293011A (en) * | 2007-04-29 | 2008-10-29 | 孔焕宇 | Novel extraction and separation method for silver yellow extract |
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660347A (en) * | 2004-01-14 | 2005-08-31 | 山东绿叶制药股份有限公司 | Yinhuang combination, oral taking preparation and injection preparation, preparing method and application |
| CN1616050A (en) * | 2004-09-24 | 2005-05-18 | 鲁南制药股份有限公司 | Yinhuang oral liquor and its producing process |
| CN101293011A (en) * | 2007-04-29 | 2008-10-29 | 孔焕宇 | Novel extraction and separation method for silver yellow extract |
Non-Patent Citations (2)
| Title |
|---|
| 张洁玫等.银黄口服液的制备及质量考核.《广东药学》.2001,第11卷(第2期),17-19. * |
| 陈竞青等.银黄口服液工艺的改进.《江西中医学院学报(增刊)》.1995,3-4. * |
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