CN106176460A - A kind of skin care compositions with sun-proof function and preparation method and application - Google Patents
A kind of skin care compositions with sun-proof function and preparation method and application Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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Abstract
The invention belongs to household chemicals field, be specifically related to a kind of skin care compositions with sun-proof function and preparation method and application.The skin care compositions with sun-proof function that the present invention provides comprises following component: natural plant extracts, Palmitoyl Tetrapeptide 7, vitamin E, oryzanol and Oligomeric Proanthocyanidins.Wherein, natural plant extracts comprises multiple natural plant sun extract; absorbing ultraviolet, removing free radical, suppression melanin generation, suppression Anaphylactic mediator release, protecting the aspect such as fibroblast and suppression matrix metal proteinase activity to have good resultant effect, there is good sun-proof result；Oligomeric Proanthocyanidins can be as oryzanol and the protective agent of vitamin E, and Oligomeric Proanthocyanidins skin is non-stimulated, has anti-oxidation protection effect to skin, can improve the skin protection anti-sunlight function of said composition.
Description
Technical field
The invention belongs to household chemicals field, be specifically related to a kind of skin care compositions with sun-proof function and preparation method thereof with
Application.
Background technology
In recent years, the fluoride gas with freon as representative is discharged in a large number, and atmospheric ozone layer is by irreversible broken
Bad, and then reduce ozone layer to the filtration of ultraviolet and iris action.Scientific investigations showed that, depletion of the ozone layer is human skin
The one of the main reasons that carcinogenesis rate constantly rises.Because the radiation of ultraviolet can change the 26S Proteasome Structure and Function of cellular component, when
When the ultraviolet radiation that cell is subject to reaches to suffer, this cell can be lost the communication capability with other cells and then apoptosis occurs.
Therefore, protection skin opposing ultraviolet radiation is the effective measures of prevention skin carcinoma.The ultraviolet that human body skin is damaged
Radiation predominantly long-wave UV radiation (UVA, wavelength 320～400nm) and band-ultraviolet B irradiation (UVB, wavelength 290～
300nm) two kinds, UVA radiation accounts for more than 90 the percent of solar radiation, the top layer of this radiation transmission to skin and corium
Layer, thus accelerate the actinic aging of skin.By contrast, UVB radiation proportion is relatively low, but it is easier to make skin shine
Black, cause DNA Damage, and then cause skin cancer.Nowadays, people with multiple method resist ultraviolet to skin long time
Between injury, wherein smearing sunscreen cream is common and effective manner.
Current sunscreen is used mostly synthetics, such as cinnamate, salicylate, benzophenone derivates；Thing
Rationality sunscreen such as titanium dioxide and zinc oxide etc., titanium and zinc oxide etc., this kind of substance having sun-screening function or easily cause skin allergy, or the thickest
Heavy, the most easy to apply.In recent years, find that some have sun-proof and anti-ultraviolet function natural plants, owing to they are to skin
Stimulate little, sun-proof while, also there is whitening and speckle dispelling, the anti-ageing effect of waiting for a long time, sun-proof have both with nutrition, thus plant sun agent is standby
Paid close attention to by outer personage.
Although the plant that report has anti-sunlight function is many, but makes the few of product.Even having developed the product of listing
Product, still lack deeper research, are unfavorable for the popularization of product.Additionally, the different extracting mode of plant, extract part, life
Long environment, its composition has bigger difference, is unfavorable for metaplasia product of seeking unity of standard, between different plants and plant and tradition sunscreen
The safety of compatibility, stability problem need to be studied further.The sunscreen single due to composition only has stronger in a certain region
Absorbing, compound prescription is advantageously.Along with the progress of technology, developing novel, all band high-selenium corn, the sunscreen of safety will be
Following target.
Summary of the invention
In order to overcome the deficiencies in the prior art and shortcoming, the primary and foremost purpose of the present invention is to provide one to have sun-proof function
Skin care compositions.
Another object of the present invention is to provide the preparation method of the above-mentioned skin care compositions with sun-proof function.
It is still another object of the present invention to provide the application of the above-mentioned skin care compositions with sun-proof function.
The purpose of the present invention is achieved through the following technical solutions:
A kind of skin care compositions with sun-proof function, comprises following component the most in parts by mass:
Described natural plant extracts is prepared by following raw material components in parts by mass:
The preparation method of described natural plant extracts, comprises the steps of:
(1) Flos Lonicerae, Herb Gynostemmae Pentaphylli, Flos Trollii, the Flos Sophorae Immaturus, Fructus Evodiae and Stigma Maydis are separately dried, pulverize and sieve, obtain gold
Flos Lonicerae coarse powder, Herb Gynostemmae Pentaphylli coarse powder, Flos Trollii coarse powder, Flos Sophorae Immaturus coarse powder, Fructus Evodiae coarse powder and Stigma Maydis coarse powder；
(2) by Flos Lonicerae coarse powder, Herb Gynostemmae Pentaphylli coarse powder, the mixing of Flos Trollii coarse powder, CO is carried out2Supercritical fluid extraction；Wherein,
Extracting temperature is 35～42 DEG C, and extracting pressure is 22～30Mpa, and extraction time is 1～2.5h, CO2Flow velocity is 14～20L/h,
Separation temperature is 35～42 DEG C, and separating pressure is 5～10Mpa；Collect extract, obtain plant extract 1；
(3) plant residue after step (2) being extracted mixes with Flos Sophorae Immaturus coarse powder, Fructus Evodiae coarse powder, carries out CO2Shooting flow
Body extracts；Wherein, dehydrated alcohol is as entrainer, and Extracting temperature is 40～45 DEG C, and extracting pressure is 25～30Mpa, during extraction
Between be 1～2.5h, CO2Flow velocity is 10～15L/h, and separation temperature is 40～45 DEG C, and separating pressure is 5～10Mpa；Collect and extract
Thing, obtains plant extract 2；
(4) plant residue after step (3) being extracted mixes with alkanols solvent, microwave radiation exaraction 3～5 times, every time
10～30min, wherein, Extracting temperature is 70～80 DEG C, and microwave power is 300～600w；Filter, merging filtrate, concentrate, obtain
Plant extract 3；
(5) Stigma Maydis coarse powder is mixed with the ethanol water that volume fraction is 50%～80%, 100～400MPa superelevation
Pressure release after pressure extraction 15～30min, filters；Filtrate is concentrated, obtains crude extract；Again with saturated ethyl acetate extraction 2～3
Secondary, collect extract, concentrate, obtain plant extract 4；
(6) the plant extract mixing prepared in step (2), (3), (4), (5), obtains natural plant extracts；
Sieving described in step (1) preferably crosses 10～20 mesh sieves；
CO described in step (2)2The condition of supercritical fluid extraction preferably Extracting temperature is 40 DEG C, extracts pressure and is
25Mpa, extraction time is 2h, CO2Flow velocity is 15L/h；Separation temperature is 40 DEG C, and separating pressure is 8Mpa；
CO described in step (3)2The condition of supercritical fluid extraction preferably Extracting temperature is 42 DEG C, extracts pressure and is
28Mpa, extraction time is 1.5h, CO2Flow velocity is 12L/h；Separation temperature is 42 DEG C, and separating pressure is 8Mpa；
Alkanols solvent described in step (4) is preferably ethanol or ethanol water；
The ethanol water that alkanols solvent more preferably volume fraction is 50%～75% described in step (4)；
The solid-liquid ratio of the microwave radiation exaraction described in step (4) is preferably (1:5)～(1:30)；
The condition of the microwave radiation exaraction described in step (4) is preferably temperature 75 DEG C, microwave power 500W；
Ethanol water preferred volume mark described in step (5) is 75%；
The condition of the hyperpressure extraction described in step (5) is preferably 300MPa and extracts 20min；
After concentration described in step (4) and (5), relative density is 1.1～1.25；
The preparation method of the described skin care compositions with sun-proof function, comprises the steps of:
By Palmitoyl Tetrapeptide-7, vitamin E, oryzanol, Oligomeric Proanthocyanidins and natural plant extracts mix homogeneously,
To the skin care compositions with sun-proof function；
The described skin care compositions with sun-proof function is applied in sunlight screening skin-protecting product；
The consumption of the skin care compositions in described sunlight screening skin-protecting product with sun-proof function is 0.1～10% (w/w), preferably
Consumption is 1～5% (w/w)；
In described sunlight screening skin-protecting product, in addition to above-mentioned required composition, can coordinate as suitably desired and generally change
The composition used in cosmetic, such as, the substrate such as other whitening agent, wetting agent, antioxidant, surfactant, alcohols, water becomes
Point；
The dosage form of described sunlight screening skin-protecting product preferably solution, suspension, emulsion, cream, paste, gel, milk, protect
Skin liquid, powder, fancy soap, oil, dry powder, foundation emulsion, wet-milling or spray；
The principle of the present invention:
Natural plant extracts in the skin care compositions with sun-proof function that the present invention provides comprises multiple natural plant
The sun-proof extract of thing, wherein, Flos Lonicerae extract has good sun-proof performance in whole ultraviolet spectra district；Herb Gynostemmae Pentaphylli extract
Containing gypenoside, aminoacid, protein, fat, flavonoid, saccharide, inorganic elements, cellulose and vitamin etc. multiple become
Point, gypenoside can significantly reduce and suppress the formation of lipid peroxidation, and strengthen human body and skin epidermal cells SOD vigor and
The ability of scavenging capacity oxygen-derived free radicals, improves the metabolism of body, and protection Skin Cell is from damage, and then prevents skin aging,
Extend cell survival, accelerate skin epidermal cells and update, the effect to skin such as ultraviolet and daylight can be resisted, prevent skin
Tanned, alleviate the chloasma that even disappears；Flos Trollii extract has good sun-proof performance to UVA and UVB, in Huai Goat
Flavone compound rutin to 330～400nm light wave have more preferable assimilation effect, it is often more important that can effectively suppress anti-
Shine the photolysis of agent self, strengthen whole compositions sun-proof result simultaneously；Containing multiple sun-prevention component in Fructus Evodiae extract, tool
Have compared with the most sun-proof ability of intensive ultraviolet absorption；Flavone in Stigma Maydis extract is to DPPH free radical, OH free radical and O2Freely
Base all has preferable Scavenging activity, wherein removes OH free radical and O2The effect of free radical is better than rutin.
The present invention has such advantages as relative to prior art and effect:
(1) having in the skin care compositions of sun-proof function that the present invention provides adds Oligomeric Proanthocyanidins, can conduct
Oryzanol and the protective agent of vitamin E, and Oligomeric Proanthocyanidins skin is non-stimulated, has anti-oxidation protection effect to skin, can carry
The skin protection anti-sunlight function of high said composition.
(2) natural plant extracts in the skin care compositions with sun-proof function that the present invention provides comprises multiple natural
Plant sun extract, is absorbing ultraviolet, removing free radical, suppression melanin generation, suppression Anaphylactic mediator release, is protecting into
The aspects such as fibrocyte and suppression matrix metal proteinase activity have good resultant effect, have good sun-proof result.
(3) present invention uses CO2The multiple extracting method such as supercritical fluid extraction, microwave radiation exaraction, hyperpressure extraction,
The extract sun-prevention component prepared is various, and effective ingredient is effectively retained.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Embodiment 1
(1) by 10 mass parts Flos Loniceraes, 3 mass parts Herb Gynostemmae Pentaphylli, 3 mass parts Flos Trolliis, the 4 mass parts Flos Sophorae Immaturus, 12 mass parts
Fructus Evodiae and 9 mass parts Stigma Maydis are separately dried, pulverized 10 mesh sieves, obtain Flos Lonicerae coarse powder, Herb Gynostemmae Pentaphylli coarse powder, Flos Trollii thick
Powder, Flos Sophorae Immaturus coarse powder, Fructus Evodiae coarse powder and Stigma Maydis coarse powder；
(2) by Flos Lonicerae coarse powder, Herb Gynostemmae Pentaphylli coarse powder, the mixing of Flos Trollii coarse powder, CO is carried out2Supercritical fluid extraction；Wherein,
Extracting temperature is 40 DEG C, and extraction pressure is 25Mpa, and extraction time is 2h, CO2Flow velocity is 15L/h, and separation temperature is 40 DEG C, point
Tripping power is 8Mpa；Collect extract, obtain plant extract 1；
(3) plant residue after step (2) being extracted mixes with Flos Sophorae Immaturus coarse powder, Fructus Evodiae coarse powder, carries out CO2Shooting flow
Body extracts；Wherein, dehydrated alcohol is as entrainer, and Extracting temperature is 42 DEG C, and extraction pressure is 28Mpa, and extraction time is 1.5h,
CO2Flow velocity is 12L/h, and separation temperature is 42 DEG C, and separating pressure is 8Mpa；Collect extract, obtain plant extract 2；
(4) plant residue after step (3) being extracted mixes with the ethanol water that volume fraction is 70%, microwave-assisted
Extracting 5 times, each 10min, wherein, solid-liquid ratio is 1:20, and Extracting temperature is 75 DEG C, and microwave power is 500w；Filter, be concentrated into
Relative density is 1.25, obtains plant extract 3；
(5) Stigma Maydis coarse powder is mixed with the ethanol water that volume fraction is 75%, 300MPa hyperpressure extraction 20min
Rear pressure release, filters；Filtrate is concentrated, obtains crude extract；Extract 3 times by saturated ethyl acetate again, collect extract, be concentrated into
Relative density is 1.25, obtains plant extract 4；
(6) the plant extract mixing prepared in step (2), (3), (4), (5), obtains natural plant extracts；
(7) by 4 mass parts Palmitoyl Tetrapeptide-7,1 mass parts vitamin Es, 6 mass parts oryzanol, the 1 oligomeric former flower of mass parts
Blue or green element and 10 mass parts natural plant extracts mix homogeneously, obtain the skin care compositions with sun-proof function.
Embodiment 2
(1) by 14 mass parts Flos Loniceraes, 1 mass parts Herb Gynostemmae Pentaphylli, 1 mass parts Flos Trollii, the 6 mass parts Flos Sophorae Immaturus, 8 mass parts Wus
The Fructus Evodiae and 10 mass parts Stigma Maydis are separately dried, pulverized 10 mesh sieves, obtain Flos Lonicerae coarse powder, Herb Gynostemmae Pentaphylli coarse powder, Flos Trollii thick
Powder, Flos Sophorae Immaturus coarse powder, Fructus Evodiae coarse powder and Stigma Maydis coarse powder；
(2) by Flos Lonicerae coarse powder, Herb Gynostemmae Pentaphylli coarse powder, the mixing of Flos Trollii coarse powder, CO is carried out2Supercritical fluid extraction；Wherein,
Extracting temperature is 35 DEG C, and extraction pressure is 30Mpa, and extraction time is 2.5h, CO2Flow velocity is 14L/h, and separation temperature is 35 DEG C,
Separating pressure is 10Mpa；Collect extract, obtain plant extract 1；
(3) plant residue after step (2) being extracted mixes with Flos Sophorae Immaturus coarse powder, Fructus Evodiae coarse powder, carries out CO2Shooting flow
Body extracts；Wherein, dehydrated alcohol is as entrainer, and Extracting temperature is 40 DEG C, and extraction pressure is 30Mpa, and extraction time is 2.5h,
CO2Flow velocity is 10L/h, and separation temperature is 40 DEG C, and separating pressure is 5Mpa；Collect extract, obtain plant extract 2；
(4) plant residue after step (3) being extracted mixes with the ethanol water that volume fraction is 50%, microwave-assisted
Extracting 3 times, each 30min, wherein, solid-liquid ratio is 1:5, and Extracting temperature is 80 DEG C, and microwave power is 600w；Filter, be concentrated into
Relative density is 1.1, obtains plant extract 3；
(5) Stigma Maydis coarse powder is mixed with the ethanol water that volume fraction is 80%, 400MPa hyperpressure extraction 15min
Rear pressure release, filters；Filtrate is concentrated, obtains crude extract；Extract 2 times by saturated ethyl acetate again, collect extract, be concentrated into
Relative density is 1.15, obtains plant extract 4；
(6) the plant extract mixing prepared in step (2), (3), (4), (5), obtains natural plant extracts；
(7) by oligomeric former to 3 mass parts Palmitoyl Tetrapeptide-7,0.5 mass parts vitamin Es, 9 mass parts oryzanol, 2 mass parts
Anthocyanidin and 12 mass parts natural plant extracts mix homogeneously, obtain the skin care compositions with sun-proof function.
Embodiment 3
(1) by 12 mass parts Flos Loniceraes, 2 mass parts Herb Gynostemmae Pentaphylli, 2 mass parts Flos Trolliis, the 5 mass parts Flos Sophorae Immaturus, 9 mass parts Wus
The Fructus Evodiae and 14 mass parts Stigma Maydis are separately dried, pulverized 20 mesh sieves, obtain Flos Lonicerae coarse powder, Herb Gynostemmae Pentaphylli coarse powder, Flos Trollii thick
Powder, Flos Sophorae Immaturus coarse powder, Fructus Evodiae coarse powder and Stigma Maydis coarse powder；
(2) by Flos Lonicerae coarse powder, Herb Gynostemmae Pentaphylli coarse powder, the mixing of Flos Trollii coarse powder, CO is carried out2Supercritical fluid extraction；Wherein,
Extracting temperature is 42 DEG C, and extraction pressure is 22Mpa, and extraction time is 1h, CO2Flow velocity is 20L/h, and separation temperature is 42 DEG C, point
Tripping power is 5Mpa；Collect extract, obtain plant extract 1；
(3) plant residue after step (2) being extracted mixes with Flos Sophorae Immaturus coarse powder, Fructus Evodiae coarse powder, carries out CO2Shooting flow
Body extracts；Wherein, dehydrated alcohol is as entrainer, and Extracting temperature is 45 DEG C, and extraction pressure is 25Mpa, and extraction time is 1h,
CO2Flow velocity is 15L/h, and separation temperature is 45 DEG C, and separating pressure is 10Mpa；Collect extract, obtain plant extract 2；
(4) plant residue after step (3) being extracted mixes with the ethanol water that volume fraction is 75%, microwave-assisted
Extracting 4 times, each 25min, wherein, solid-liquid ratio is 1:30, and Extracting temperature is 70 DEG C, and microwave power is 300w；Filter, be concentrated into
Relative density is 1.15, obtains plant extract 3；
(5) Stigma Maydis coarse powder is mixed with the ethanol water that volume fraction is 50%, 100MPa hyperpressure extraction 30min
Rear pressure release, filters；Filtrate is concentrated, obtains crude extract；Extract 3 times by saturated ethyl acetate again, collect extract, concentrate phase
It is 1.1 to density, obtains plant extract 4；
(6) the plant extract mixing prepared in step (2), (3), (4), (5), obtains natural plant extracts；
(7) by low to 3.5 mass parts Palmitoyl Tetrapeptide-7,0.8 mass parts vitamin Es, 8 mass parts oryzanol, 0.5 mass parts
Poly-procyanidin and 14 mass parts natural plant extracts mix homogeneously, obtain the skin care compositions with sun-proof function.
Effect example
One, detection method
The skin care compositions sulfone with dimethyl Asia with sun-proof function is configured to concentration by what embodiment 1～3 prepared respectively
For the active ingredient solution of mass volume ratio 1%, carry out following experiment.
(1) mensuration of free radical scavenging effect
Take active ingredient solution 2mL and diphenyl picryl phenylhydrazine (DPPH) solution that concentration is 100 μm ol/L (this solution
Solvent is for water) 2mL successively adds in same tool plug test tube, shakes up；Left at room temperature 30 minutes, with solvent for blank in
Sample absorbance is measured under 517nm wavelength.
Suppression ratio: K%=[1-(Ai-Aj)/Ac] × 100%；
The absorbance of Ai:2mL DPPH solution+2mL active ingredient solution；
The absorbance of Aj:2mL active ingredient solution+2mL solvent (i.e. dimethyl sulfoxide)；
The absorbance of Ac:2mL DPPH solution+2mL solvent (i.e. dimethyl sulfoxide).
(2) anti-ultraviolet property measures
In 280～400nm wave-length coverages, it is scanned every 10nm, determines the saturating of active ingredient solution under each wavelength
Light rate, calculates the average absorption ratio of wave-length coverage.
(3) tyrosine vitality test in suppression mouse melanin cell
The B16 mouse melanin cell (Shanghai cell institute of the Chinese Academy of Sciences) being in exponential phase is inoculated in 96 orifice plates,
Culture medium is the calf serum of RPMI1640+ percent by volume 10%, every hole 100 μ L (104Individual cells/well), put 37 DEG C, 5%
CO2After incubator cultivates 24h, add the active ingredient solution 50 μ L after filtration sterilization.After continuing to cultivate 3d, supernatant discarded
Liquid, rinses twice with 0.15% (w/v) poly butylene succinate that pH value is 6.8, and every hole adds 90 μ L containing 1% (volume fraction)
The PBS (0.01M, pH value 7.4) of Triton X-100.Ultrasonication in ice bath, every hole adds the L-3,4 dihydroxyphenylalanine of 10 μ L 10mmol/L
(L-dopa), hatching 60min for 37 DEG C, colorimetric at 475nm, blank well returns to zero, surveys each hole absorbance.
Suppression ratio=(1-medicine group mean absorbance values ÷ matched group mean absorbance values) × 100%
(4) melanin genesis test in suppression mouse melanin cell
By B16 mouse black-in tumor cell with 1 × 105The density of individual/mL is inoculated in the culture dish of a diameter of 9cm, 37 DEG C,
5%CO2Under conditions of cultivate 2 days, abandon supernatant, add the active ingredient solution 18～22mL after filtration sterilization, be then incubated for 3
My god, abandoning supernatant, (0.01M, pH value 7.4) PBS washs, and every hole adds the trypsin solution digestion of 0.5mL mass percent 0.2%
Cell 3min, every ware adds 2mL and maintains liquid to terminate digestion.After piping and druming mixing, every kind of concentration is taken out 0.5mL and is made cell counting.Remaining
Cell suspension is centrifuged 5min with 2500r/min, abandons supernatant, adds NaOH solution in precipitation, and heating makes melanin dissolve, choosing
Select survey absorbance on the enzyme-linked immunosorbent assay instrument of 490nm wavelength.
B16 cell suppression ratio=[1-(medicine hole absorbance ÷ medicine porocyte density) ÷ (control wells absorbance
Value ÷ control wells cell density)] × 100%
Two, result of the test:
(1) mensuration of free radical scavenging effect, result is as shown in table 1:
The mensuration of the skin care compositions free radical scavenging effect with sun-proof function that table 1 embodiment 1～3 prepares
| Embodiment | Suppression ratio (%) |
| Embodiment 1 | 96.5 |
| Embodiment 2 | 94.2 |
| Embodiment 3 | 95.7 |
(2) anti-ultraviolet property measures, and result is as shown in table 2:
The skin care compositions anti-ultraviolet property with sun-proof function that table 2 embodiment 1～3 prepares measures
| Embodiment | 280～320nm absorbances (%) | 320～400nm absorbances (%) |
| Embodiment 1 | 100 | 99.6 |
| Embodiment 2 | 100 | 98.5 |
| Embodiment 3 | 100 | 99.2 |
(3) tyrosine vitality test in suppression mouse melanin cell, result is as shown in table 3:
Tyrosine vitality test result in table 3 embodiment 1～3 suppression mouse melanin cell
(4) melanin genesis test in suppression mouse melanin cell, result is as shown in table 4:
Melanin genesis result of the test in table 4 embodiment 1～3 suppression mouse melanin cell
| Embodiment | Suppression ratio (%) |
| Embodiment 1 | 68.3 |
| Embodiment 2 | 63.4 |
| Embodiment 3 | 65.6 |
Result above shows: the skin care compositions with sun-proof function that the present invention provides is absorbing ultraviolet, removing certainly
Produced by base, suppression melanin, the suppression aspect such as tyrosinase activity there is good resultant effect, have the most sun-proof
Effect.
Application Example
Take 5% (w/w) respectively has the skin care compositions of sun-proof function, the glycerol of 15% (w/w), 10% (w/w)
Sorbitol olein, the purified water of 65% (w/w) make sun care preparations emulsion.
This emulsion has good sun-proof result.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment
Limit, the change made under other any spirit without departing from the present invention and principle, modify, substitute, combine, simplify,
All should be the substitute mode of equivalence, within being included in protection scope of the present invention.
Claims (10)
1. a skin care compositions with sun-proof function, it is characterised in that comprise following component the most in parts by mass:
Described natural plant extracts is prepared by following raw material components in parts by mass:
The skin care compositions with sun-proof function the most according to claim 1, it is characterised in that:
The preparation method of described natural plant extracts, comprises the steps of:
(1) Flos Lonicerae, Herb Gynostemmae Pentaphylli, Flos Trollii, the Flos Sophorae Immaturus, Fructus Evodiae and Stigma Maydis are separately dried, pulverize and sieve, obtain Flos Lonicerae
Coarse powder, Herb Gynostemmae Pentaphylli coarse powder, Flos Trollii coarse powder, Flos Sophorae Immaturus coarse powder, Fructus Evodiae coarse powder and Stigma Maydis coarse powder；
(2) by Flos Lonicerae coarse powder, Herb Gynostemmae Pentaphylli coarse powder, the mixing of Flos Trollii coarse powder, CO is carried out2Supercritical fluid extraction；Wherein, extract
Temperature is 35～42 DEG C, and extracting pressure is 22～30Mpa, and extraction time is 1～2.5h, CO2Flow velocity is 14～20L/h, separates
Temperature is 35～45 DEG C, and separating pressure is 5～10Mpa；Collect extract, obtain plant extract 1；
(3) plant residue after step (2) being extracted mixes with Flos Sophorae Immaturus coarse powder, Fructus Evodiae coarse powder, carries out CO2Supercritical fluid extracts
Take；Wherein, dehydrated alcohol is as entrainer, and Extracting temperature is 40～45 DEG C, and extracting pressure is 25～30Mpa, and extraction time is 1
～2.5h, CO2Flow velocity is 10～15L/h, and separation temperature is 35～45 DEG C, and separating pressure is 5～10Mpa；Collect extract,
To plant extract 2；
(4) by step (3) extract after plant residue mix with alkanols solvent, microwave radiation exaraction 3～5 times, each 10～
30min, wherein, Extracting temperature is 70～80 DEG C, and microwave power is 300～600w；Filter, concentrate, obtain plant extract 3；
(5) being mixed with the ethanol water that volume fraction is 50%～80% by Stigma Maydis coarse powder, 100～400MPa supertension carry
Pressure release after taking 15～30min, filters；Filtrate is concentrated, obtains crude extract；Extract 2～3 times by saturated ethyl acetate again, receive
Collection extract, concentrates, obtains plant extract 4；
(6) the plant extract mixing prepared in step (2), (3), (4), (5), obtains natural plant extracts.
The skin care compositions with sun-proof function the most according to claim 2, it is characterised in that:
CO described in step (2)2The condition of supercritical fluid extraction is Extracting temperature 40 DEG C, extracts pressure 25Mpa, during extraction
Between be 2h, CO2Flow velocity is 15L/h；Separation temperature 37 DEG C, separating pressure is 8Mpa.
The skin care compositions with sun-proof function the most according to claim 2, it is characterised in that:
CO described in step (3)2The condition of supercritical fluid extraction is Extracting temperature 42 DEG C, extracts pressure 28Mpa, during extraction
Between be 1.5h, CO2Flow velocity is 12L/h；Separation temperature 40 DEG C, separating pressure is 8Mpa.
The skin care compositions with sun-proof function the most according to claim 2, it is characterised in that:
Alkanols solvent described in step (4) is ethanol or ethanol water.
The skin care compositions with sun-proof function the most according to claim 2, it is characterised in that:
The solid-liquid ratio of the microwave radiation exaraction described in step (4) is (1:5)～(1:30)；
The condition of the microwave radiation exaraction described in step (4) is temperature 75 DEG C, microwave power 500W.
The skin care compositions with sun-proof function the most according to claim 2, it is characterised in that:
The condition of the hyperpressure extraction described in step (5) is that 300MPa extracts 20min.
The skin care compositions with sun-proof function the most according to claim 2, it is characterised in that:
After concentration described in step (4) and (5), relative density is 1.1～1.25.
9. the skin care compositions with sun-proof function described in any one of claim 1～8 is applied in sunlight screening skin-protecting product.
The skin care compositions with sun-proof function the most according to claim 9 is applied in sunlight screening skin-protecting product, and its feature exists
In:
The dosage form of described sunlight screening skin-protecting product be solution, suspension, emulsion, cream, paste, gel, milk, skin care liquid, powder,
Fancy soap, oil, dry powder, foundation emulsion, wet-milling or spray.
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| CN114767611A (en) * | 2022-05-31 | 2022-07-22 | 安徽天康医疗科技股份有限公司 | Comprehensive skin care cream for children |
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