CN106174469A - A kind of fatigue resistant health food compositions and health food preparation - Google Patents

A kind of fatigue resistant health food compositions and health food preparation Download PDF

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Publication number
CN106174469A
CN106174469A CN201610496389.2A CN201610496389A CN106174469A CN 106174469 A CN106174469 A CN 106174469A CN 201610496389 A CN201610496389 A CN 201610496389A CN 106174469 A CN106174469 A CN 106174469A
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China
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health food
powder
oligopeptide
fatigue resistant
food compositions
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CN201610496389.2A
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Chinese (zh)
Inventor
尹利端
石丽花
王桐
徐宏楠
鞠东
杨长军
曲涛
衣洁菡
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YANTAI NEW ERA HEALTH INDUSTRY Co Ltd
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YANTAI NEW ERA HEALTH INDUSTRY Co Ltd
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Priority to CN201610496389.2A priority Critical patent/CN106174469A/en
Publication of CN106174469A publication Critical patent/CN106174469A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention belongs to field of health care food, particularly relate to a kind of fatigue resistant health food compositions and health food preparation.The oligopeptide deriving from wheat protein, soybean protein and animal collagen is combined by the present invention, add Semen Armeniacae Amarum powder, red date powder, oatmeal and cheese powder composition for fatigue resistant health food, can effectively improve the change of the metabolite such as hepatic glycogen content under organism fatigue state, serum urea nitrogen content, Serum lactic acid content, be effectively improved body health situation.

Description

A kind of fatigue resistant health food compositions and health food preparation
Technical field
The invention belongs to field of health care food, particularly relate to a kind of fatigue resistant health food compositions and health food system Agent.
Background technology
Along with increasing and the quickening of rhythm of life of people's operating pressure, fatigue has become that society is the most universal Problem.Human body is in the physical work or motor process of excess, if metabolite can not be by suitable rest or its other party Formula is removed, and accumulates to a certain degree will produce physical fatigue in vivo.Fatigue is to tackle self failure function at body Time a kind of protective response of producing, its generation reminds worker should lower working strength or terminate motion in order to avoid body is subject to Damage.Fatigue has become as a kind of consequential damages health and even directly results in the inducement that numerous disease produces.
Research finds, the energy matter produced when tired generation and body excess activity is exhausted and the accumulation of metabolite Relevant.Hepatic glycogen homenergic material can be made under organism fatigue state to consume excessively, thus have impact on the supply of human body energy, cause Blood glucose declines, and protein, amino acid whose consumption also increase, and cause the metabolites such as carbamide to be piled up in blood.Fatigue also can Causing the acidic metabolites such as the lactic acid in body, acetone acid to be accumulated in a large number, change the interior environment of body, this can further The generation of aggravation fatigue symptom.Therefore, hepatic glycogen content, serum urea nitrogen content, Serum lactic acid content etc. under organism fatigue state The change of metabolite is often taken as weighing whether certain material has the inspection target of anti-fatigue effect.
Oligopeptide is with macro-molecular protein as raw material, through biological enzymolysis, separation, purification, be dried etc. the course of processing make Small-molecule active substance.Research shows, compares with macro-molecular protein, and oligopeptide not only has the nutrition attribute of protein, But also there is plurality of health care functions, including resisting fatigue, blood pressure lowering, antioxidation etc..Oligopeptide has the feature of easily absorption, and it is inhaled Yield is far above macro-molecular protein or single free amino acid.Oligopeptide also has soluble, to be difficult to sensitization excellent processing Characteristic.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, it is provided that a kind of fatigue resistant health food compositions and health food preparation.
First purpose of the present invention is to provide a kind of fatigue resistant health food compositions, consists of the following composition: little Wheat oligopeptide 20-40 part, soybean oligopeptide 5-25 part and collagen oligopeptide 5-10 part.
Preferably, a kind of fatigue resistant health food compositions, consist of the following composition: Semen Tritici aestivi oligopeptide 30 parts, Semen sojae atricolor are low Poly-peptide 15 parts and collagen oligopeptide 8 parts.
Wherein, described Semen Tritici aestivi oligopeptide molecular weight is 65.0-85.0wt% less than 1000 daltonian ratios;Described Semen sojae atricolor Oligopeptide molecular weight is 70.0-85.0wt% less than 1000 daltonian ratios;Described collagen oligopeptide molecular weight is less than 3000 Daltonian ratio is 75.0-85.0wt%.
Above-mentioned fatigue resistant health food compositions also includes: Semen Armeniacae Amarum powder 5-15 part, red date powder 5-25 part, oatmeal 20-40 Part and cheese powder 5-10 part.
Preferably, described fatigue resistant health food compositions also includes: Semen Armeniacae Amarum powder 10 parts, red date powder 10 parts, oatmeal 30 Part and cheese powder 7 parts.
Wherein, described Semen Armeniacae Amarum powder is with Semen Armeniacae Amarum as raw material, selected, soak, remove the peel, detoxification, defibrination, homogenizing, concentrate, dry Dry process technique and prepare;Described red date powder is with Drying Dates as raw material, cleaned, soak, precook, pull an oar, filter, dense Contracting, sterilizing, drying process process and prepare;Described oatmeal is with Herba bromi japonici as raw material, size-reduced, enzymolysis, filter, concentrate, dry Dry process and prepare;Described cheese powder is with cheese as raw material, carry out fermenting after the thawing that adds water, allocate, sterilizing, at spray drying Manage and prepare.
Second object of the present invention is to provide the preparation method of above-mentioned fatigue resistant health food compositions: Semen Tritici aestivi is low Poly-peptide, soybean oligopeptide, collagen oligopeptide, Semen Armeniacae Amarum powder, red date powder, oatmeal and cheese powder 40 mesh sieves excessively respectively, extracting screen underflow, By each raw material by above-mentioned number mix homogeneously.
Third object of the present invention is to provide a kind of health food preparation, and its component is by weight percentage: anti- Tired health-care food composition 50-70% and adjuvant 30-50%.
Wherein, described adjuvant be maltodextrin, xylitol, erythritol, hydroxyl isomaltulose, oligomeric isomaltose, The two or more mixing of lactose, neotame, acesulfame potassium, stevioside or citric acid.
The dosage form of above-mentioned health food preparation is granule, powder, capsule, tablet or oral liquid.
The invention has the beneficial effects as follows: the present invention will derive from the low of wheat protein, soybean protein and animal collagen Poly-peptide combines, and adds Semen Armeniacae Amarum powder, red date powder, oatmeal and cheese powder composition for fatigue resistant health food, it is possible to effectively Improve the change of the metabolite such as hepatic glycogen content under organism fatigue state, serum urea nitrogen content, Serum lactic acid content, be effectively improved Body health situation.
Detailed description of the invention
Being described principle and the feature of the present invention below in conjunction with example, example is served only for explaining the present invention, and Non-for limiting the scope of the present invention.
Embodiment 1 fatigue resistant health food compositions
A kind of fatigue resistant health food compositions, consists of the following composition: Semen Tritici aestivi oligopeptide 30g, soybean oligopeptide 15g, Collagen oligopeptide 8g, Semen Armeniacae Amarum powder 10g, red date powder 15g, oatmeal 30g and cheese powder 7g.
Above-mentioned each raw material is crossed respectively 40 mesh sieves, extracting screen underflow, according to above-mentioned parts by weight mix homogeneously, obtains powder mixing Thing 115g, is designated as prescription 1#.
Embodiment 2 fatigue resistant health food compositions
A kind of fatigue resistant health food compositions, consists of the following composition: Semen Tritici aestivi oligopeptide 20g, soybean oligopeptide 25g, Collagen oligopeptide 5g, Semen Armeniacae Amarum powder 15g, red date powder 25g, oatmeal 20g and cheese powder 10g.
Above-mentioned each raw material is crossed respectively 40 mesh sieves, extracting screen underflow, according to above-mentioned parts by weight mix homogeneously, obtains powder mixing Thing 120g, is designated as prescription 2#.
Embodiment 3 fatigue resistant health food compositions
A kind of fatigue resistant health food compositions, consists of the following composition: Semen Tritici aestivi oligopeptide 40g, soybean oligopeptide 5g, glue Collagen oligopeptide 10g, Semen Armeniacae Amarum powder 5g, red date powder 5g, oatmeal 40g and cheese powder 5g.
Above-mentioned each raw material is crossed respectively 40 mesh sieves, extracting screen underflow, according to above-mentioned parts by weight mix homogeneously, obtains powder mixing Thing 110g, is designated as prescription 3#.
Embodiment 4 fatigue resistant health food compositions
A kind of fatigue resistant health food compositions, consists of the following composition: Semen Tritici aestivi oligopeptide 30g, soybean oligopeptide 15g and Collagen oligopeptide 8g.
Above-mentioned each raw material is crossed respectively 40 mesh sieves, extracting screen underflow, according to above-mentioned parts by weight mix homogeneously, obtains powder mixing Thing 53g, is designated as prescription 4#.
Embodiment 5 fatigue resistant health food compositions
A kind of fatigue resistant health food compositions, consists of the following composition: Semen Tritici aestivi oligopeptide 20g, soybean oligopeptide 25g and Collagen oligopeptide 10g.
Above-mentioned each raw material is crossed respectively 40 mesh sieves, extracting screen underflow, according to above-mentioned parts by weight mix homogeneously, obtains powder mixing Thing 55g, is designated as prescription 5#.
Embodiment 6 fatigue resistant health food compositions
A kind of fatigue resistant health food compositions, consists of the following composition: Semen Tritici aestivi oligopeptide 40g, soybean oligopeptide 5g and Collagen oligopeptide 5g.
Above-mentioned each raw material is crossed respectively 40 mesh sieves, extracting screen underflow, according to above-mentioned parts by weight mix homogeneously, obtains powder mixing Thing 50g, is designated as prescription 6#.
It is object of study by the composition sample of embodiment 1-6, mice is carried out the feeding trial of 30 days by a definite date.With reference to defending The evaluation methodology of the alleviating physical fatigue effect of regulation in life portion " health food inspection technology and value disciplines ", determination test is little The walking weight load of Mus, serum urea nitrogen, hepatic glycogen content and Serum lactic acid content, evaluate the anti-fatigue effect of each compositions.
1 test material and key instrument
1.1 experimental animal
SPF level Male Kunming strain mice, body weight 18-22g, purchased from Fukang bio tech ltd of Beijing China.
1.2 main agents
Serum urea nitrogen determination test kit;Hepatic glycogen measures test kit;Blood lactase acid measures test kit;Other reagent are domestic Chromatographically pure or analytical pure.
1.3 key instrument
Swimming trunk (size is 70cm × 60cm × 40cm);TU-1901 ultraviolet-uisible spectrophotometer;AU400 is full-automatic Biochemistry analyzer;BP-3100 analytical balance;Desk centrifuge.
2 test methods
2.1 test method
By mice random packet, between group, body weight is without significant difference. the composition sample of embodiment 1-6 is respectively set basic, normal, high Three dosage groups, wherein the composition sample gavage amount of embodiment 1-3 is respectively 0.84,1.67 and 3.34g/ (kg 〃 bw), implements The composition sample gavage amount of example 4-6 is respectively 0.20,0.40 and 0.80g/ (kg 〃 bw), separately sets (the distillation of a negative control group Water), each test group mice carries out Loaned swimming test, serum urea nitrogen determination respectively, blood lactase acid measures, hepatic glycogen measures 4 Test, often 10 mices of group.Test each compositions test group for 4 and all give tested material 1 time by above-mentioned dosage per os every day (20mL/ (kg 〃 bw) gavage capacity), negative control group gives equal-volume distilled water.All animals are according to dosage designed the most continuously After gavage 30d, measure indices respectively.
2.2 assay method
2.2.1 swimming with a load attached to the body experiment
Mice, to 30min after sample, is put into swimming trunk went swimming, depth of water 30cm, water temperature (25 ± 1) DEG C, Mus by last gavage The sheet lead of root of the tail portion load 5% body weight, records each group of mice swimming time, calculates each group of average swim time.
2.2.2 serum urea nitrogen determination
30min after last gavage is to sample, puts into not swimming with a load attached to the body 90min in the water that temperature is 30 DEG C by mice, takes out Dry, take a blood sample after rest 60min, centrifugal, take serum and measure serum urea nitrogen content by serum urea nitrogen test kit requirement method.
2.2.3 hepatic glycogen measures
After last gavage is to sample, 30min puts to death mice, takes liver, and suck dry moisture after rinsing in normal saline, by liver Glycogen test kit requires that method measures hepatic glycogen content.
2.2.4 blood lactase acid measures
Last gavage is to 30min after sample, and mice is at the water went swimming 10min that temperature is 30 DEG C.Before swimming, after swimming not Have a rest and rest 20min after swimming, take a blood sample respectively at the ophthalmic corner of the eyes, measure test kit requirement method mensuration blood lactase acid by blood lactase acid and contain Amount.
2.3 data analysis
With SPSS software, experimental data being carried out statistical analysis, compare employing t inspection between group, p < 0.05 indicates notable Sex differernce, p < 0.01 indicates pole significant difference.
3 results and analysis
The impact on Mouse Weight of 3.1 test specimens
After per os gives tested material 30d of mice various dose, each test specimen group Mouse Weight and negative control group it Between difference the most not there is significance (p > 0.05), show that the body weight of mice is increased by test specimen and have no adverse effects.
The impact on the mice burden swimming time of 3.2 test specimens
As shown in Table 1,1-6# compositions each dosetest group mice burden swimming time relatively negative control group all has prolongation, Wherein in the middle and high dosage group of compositions 1# and compositions 3#, the dosage group mice burden swimming time compares with negative control group and has Pole significant difference (p < 0.01), it addition, except compositions 2#, low dose group mice burden swimming time and the feminine gender of 3#, 4#, 6# Matched group compares and there was no significant difference (p > 0.05) outward, and remaining test group compares with negative control group all significant difference, table Bright compositions 1-6# is respectively provided with the effect extending the mice burden swimming time.
The impact on Mouse Liver glycogen content of 3.3 test specimens
As shown in Table 1, the hepatic glycogen content of 1-6# compositions each dosetest group mice obviously higher than negative control group, In addition to the hepatic glycogen content of 5# compositions each dosetest group mice compares with negative control group and there was no significant difference (p > 0.05), Other compositionss all have one or two dosage group to compare with negative control group and have significant difference (p < 0.05), show that it has Promote the effect of mice liver glycogen reserves.
The impact on mice serum urea nitrogen content of 3.4 test specimens
The catabolism of body over-activity meeting acceleration bodies internal protein, causes the urea content of blood to increase, the most often Using serum urea nitrogen as the reference index of organism fatigue degree.As shown in Table 1,1-6# compositions each dosetest group mice with Negative control group compares, and serum urea nitrogen level all decreases, wherein except the serum urea of 3# compositions each dosage group mice Nitrogen level compares with negative control group and there was no significant difference outer (p > 0.05), other compositionss all have one or two dosage group with Negative control group compares significant difference (p < 0.05), shows that it has and reduces motor process small mouse protein depletion amount Effect.
Table 1 embodiment 1-6# compositions is on mice burden swimming time, hepatic glycogen content, the impact (n=of serum urea nitrogen 10)
Note: * * represents to compare with negative control group have pole significant difference, p < 0.01;
* represent to compare with negative control have significant difference, p < 0.05.
The impact on Mouse Blood lactate level of the 3.5 test specimen peptides
As shown in Table 2,1-6# compositions compares by each dosetest group mice with negative control group, blood lactase acid area under curve All decrease, wherein compare with negative control group without notable except 1#, 4# compositions test group Mouse Blood lactic acid area under curve Outward, other 4 compositionss all have one or two dosetest group mice to compare with negative control group and have sex differernce (p > 0.05) Significant difference (p < 0.05) or pole significant difference (p < 0.01), show that it has Mouse Blood lactic acid build after removing is moved Effect.
The impact (n=10) on Mouse Blood lactate level of the table 2 embodiment 1-6# compositions
Note: * * represents to compare with negative control group have pole significant difference, p < 0.01;
* represent to compare with negative control have significant difference, p < 0.05.
According in " health food inspection with assessment technique specification " alleviating physical fatigue health care criterion: " Mus swimming with a load attached to the body experimental result is positive, and any 2 positives in blood lactase acid, serum urea nitrogen, 3 indexs of hepatic glycogen, can determine that This given the test agent has the effect of function of physical fatigue alleviation ".According to this decision rule, the result of the test of 1-6# compositions all accords with Close this criterion, it is possible to determine that 1-6# compositions is respectively provided with the effect of alleviating physical fatigue.
Embodiment 7 health food preparation
A kind of health food preparation, consists of the following composition: Semen Tritici aestivi oligopeptide 30g, soybean oligopeptide 15g, collagen are oligomeric Peptide 8g, Semen Armeniacae Amarum powder 10g, red date powder 15g, oatmeal 30g, cheese powder 7g, erythritol 30g and hydroxyl isomaltulose 55g.
Above-mentioned each raw material is crossed respectively 40 mesh sieves, extracting screen underflow, according to above-mentioned parts by weight mix homogeneously, adds 15g pure Change water, as binding agent, wet granulation, is crossed 14 mesh sieves, is dried to pellet moisture≤5%, obtains granular pattern mixture 200g.
Embodiment 8 health food preparation
A kind of health food preparation, consists of the following composition: Semen Tritici aestivi oligopeptide 30g, soybean oligopeptide 15g, collagen are oligomeric Peptide 8g, Semen Armeniacae Amarum powder 10g, red date powder 15g, oatmeal 30g, cheese powder 7g, lactose 65g and hydroxyl isomaltulose 50g.
Above-mentioned each raw material is crossed respectively 40 mesh sieves, extracting screen underflow, according to above-mentioned parts by weight mix homogeneously, adds 8g ethanol As binding agent, pelletize, cross 18 mesh sieves, be dried to obtain dry granule, this dry granule is mixed homogeneously with 1g magnesium stearate, tabletting, Tablet weight is the plain sheet 210g of 0.80 gram.
Embodiment 9 health food preparation
A kind of health food preparation, consists of the following composition: Semen Tritici aestivi oligopeptide 30g, soybean oligopeptide 15g, collagen are oligomeric Peptide 8g, Semen Armeniacae Amarum powder 10g, red date powder 15g, oatmeal 30g, cheese powder 7g, hydroxyl isomaltulose 50g, citric acid 1.2g and Flos Chrysanthemi Glucosides 0.2g.
50-60 DEG C of purified water of above each component 1200ml is fully dissolved, at homogenizing, filtration, sterilizing, fill Reason, obtains oral liquid goods 1300ml.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (8)

1. a fatigue resistant health food compositions, it is characterised in that consist of the following composition: Semen Tritici aestivi oligopeptide 20-40 part, big Bean oligopeptide 5-25 part and collagen oligopeptide 5-10 part.
Fatigue resistant health food compositions the most according to claim 1, it is characterised in that consist of the following composition: Semen Tritici aestivi Oligopeptide 30 parts, soybean oligopeptide 15 parts and collagen oligopeptide 8 parts.
Fatigue resistant health food compositions the most according to claim 1 and 2, it is characterised in that described Semen Tritici aestivi oligopeptide divides Son amount is 65.0-85.0wt% less than 1000 daltonian ratios;Described soy oligosaccharides peptide molecular weight is daltonian less than 1000 Ratio is 70.0-85.0wt%;Described collagen oligopeptide molecular weight is 75.0-85.0wt% less than 3000 daltonian ratios.
Fatigue resistant health food compositions the most according to claim 1 and 2, it is characterised in that also include Semen Armeniacae Amarum powder 5-15 Part, red date powder 5-25 part, oatmeal 20-40 part and cheese powder 5-10 part.
Fatigue resistant health food compositions the most according to claim 4, it is characterised in that also include Semen Armeniacae Amarum powder 10 parts, red Date powder 10 parts, oatmeal 30 parts and cheese powder 7 parts.
Fatigue resistant health food compositions the most according to claim 5, it is characterised in that described Semen Armeniacae Amarum powder is to be with Semen Armeniacae Amarum Raw material, selected, soak, remove the peel, detoxification, defibrination, homogenizing, concentration, dry treatment process and prepare;Described red date powder is with dry Dry red date as raw materials, cleaned, soak, precook, pull an oar, filter, concentrate, sterilizing, drying process process and prepare;Described Herba bromi japonici Powder is with Herba bromi japonici as raw material, size-reduced, enzymolysis, filter, concentrate, dried and prepare;Described cheese powder is to be former with cheese Material, carry out fermenting after the thawing that adds water, allocate, sterilizing, spray drying treatment and prepare.
7. a health food preparation, it is characterised in that its component is by weight percentage: fatigue resistant health food compositions 50-70% and adjuvant 30-50%.
Health food preparation the most according to claim 7, it is characterised in that described adjuvant be maltodextrin, xylitol, Two kinds of erythritol, hydroxyl isomaltulose, oligomeric isomaltose, lactose, neotame, acesulfame potassium, stevioside or citric acid with Upper mixing.
CN201610496389.2A 2016-06-28 2016-06-28 A kind of fatigue resistant health food compositions and health food preparation Pending CN106174469A (en)

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Cited By (6)

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CN109363187A (en) * 2018-09-14 2019-02-22 黑龙江飞鹤乳业有限公司 It is a kind of to adjust immune, antifatigue and relax bowel and defecation composition and preparation method thereof
CN110338430A (en) * 2019-07-04 2019-10-18 山东薇薇朵生物科技有限公司 Ginseng oligopeptide is preparing the purposes in antifatigue food or health food
CN111165758A (en) * 2020-01-14 2020-05-19 广州博罗霍生物科技有限公司 Anti-fatigue Baoleguo oral liquid and preparation method and application thereof
CN113100320A (en) * 2021-04-12 2021-07-13 武汉轻工大学 Walnut oligopeptide candy with function of relieving sub-health fatigue and preparation method thereof
CN113273698A (en) * 2021-05-26 2021-08-20 黑龙江冰泉多多保健食品有限责任公司 Anti-fatigue soybean protein powder and preparation method thereof
CN115944091A (en) * 2023-02-21 2023-04-11 江苏艾兰得营养品有限公司 Anti-fatigue tablet and preparation method and application thereof

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109363187A (en) * 2018-09-14 2019-02-22 黑龙江飞鹤乳业有限公司 It is a kind of to adjust immune, antifatigue and relax bowel and defecation composition and preparation method thereof
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CN111165758A (en) * 2020-01-14 2020-05-19 广州博罗霍生物科技有限公司 Anti-fatigue Baoleguo oral liquid and preparation method and application thereof
CN113100320A (en) * 2021-04-12 2021-07-13 武汉轻工大学 Walnut oligopeptide candy with function of relieving sub-health fatigue and preparation method thereof
CN113273698A (en) * 2021-05-26 2021-08-20 黑龙江冰泉多多保健食品有限责任公司 Anti-fatigue soybean protein powder and preparation method thereof
CN115944091A (en) * 2023-02-21 2023-04-11 江苏艾兰得营养品有限公司 Anti-fatigue tablet and preparation method and application thereof

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