CN106164289A - 癌症对免疫疗法的反应的决定因素 - Google Patents
癌症对免疫疗法的反应的决定因素 Download PDFInfo
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- CN106164289A CN106164289A CN201480075287.2A CN201480075287A CN106164289A CN 106164289 A CN106164289 A CN 106164289A CN 201480075287 A CN201480075287 A CN 201480075287A CN 106164289 A CN106164289 A CN 106164289A
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- A61P35/00—Antineoplastic agents
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5751—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the skin, e.g. melanoma
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
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- Biotechnology (AREA)
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- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
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- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461923183P | 2014-01-02 | 2014-01-02 | |
| US61/923,183 | 2014-01-02 | ||
| US201462066034P | 2014-10-20 | 2014-10-20 | |
| US62/066,034 | 2014-10-20 | ||
| US201462072893P | 2014-10-30 | 2014-10-30 | |
| US62/072,893 | 2014-10-30 | ||
| PCT/US2014/072125 WO2015103037A2 (en) | 2014-01-02 | 2014-12-23 | Determinants of cancer response to immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106164289A true CN106164289A (zh) | 2016-11-23 |
Family
ID=53494217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480075287.2A Pending CN106164289A (zh) | 2014-01-02 | 2014-12-23 | 癌症对免疫疗法的反应的决定因素 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20160326597A1 (https=) |
| EP (1) | EP3090066A4 (https=) |
| JP (1) | JP2017504324A (https=) |
| KR (1) | KR20160102314A (https=) |
| CN (1) | CN106164289A (https=) |
| AU (1) | AU2014374020A1 (https=) |
| BR (1) | BR112016015399A2 (https=) |
| CA (1) | CA2935214A1 (https=) |
| CL (1) | CL2016001708A1 (https=) |
| MX (1) | MX2016008771A (https=) |
| PE (1) | PE20161344A1 (https=) |
| PH (1) | PH12016501329A1 (https=) |
| RU (1) | RU2707530C2 (https=) |
| SG (2) | SG11201605432RA (https=) |
| WO (1) | WO2015103037A2 (https=) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110295218A (zh) * | 2018-03-22 | 2019-10-01 | 长庚医疗财团法人嘉义长庚纪念医院 | 量化靶基因的突变型等位基因负担的方法 |
| CN110770838A (zh) * | 2017-12-01 | 2020-02-07 | Illumina公司 | 用于确定体细胞突变克隆性的方法和系统 |
| CN110997943A (zh) * | 2017-07-05 | 2020-04-10 | 弗朗西斯.克里克研究所 | 评估癌症免疫疗法的适合性的方法 |
| CN111088349A (zh) * | 2020-02-14 | 2020-05-01 | 深圳市宝安区妇幼保健院 | Kir3dl1基因分型引物组及其应用 |
| CN111432837A (zh) * | 2017-09-25 | 2020-07-17 | 纪念斯隆凯特琳癌症中心 | 肿瘤突变负荷和检查点免疫疗法 |
| CN111566484A (zh) * | 2017-11-09 | 2020-08-21 | 宾夕法尼亚大学董事会 | 细胞外囊泡蛋白及其在癌症诊断、预测对疗法的反应和治疗中的用途 |
| CN112424382A (zh) * | 2019-04-05 | 2021-02-26 | Illumina公司 | Hla多样性的定量评分 |
| CN114245874A (zh) * | 2019-05-24 | 2022-03-25 | 艾迪菲斯健康有限公司 | 用于癌症免疫疗法的精准医学方法 |
| CN115667550A (zh) * | 2020-03-23 | 2023-01-31 | 皇家飞利浦有限公司 | 基于免疫检查点基因对前列腺癌对象的放疗反应的预测 |
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| US9732131B2 (en) | 2006-02-27 | 2017-08-15 | Calviri, Inc. | Identification and use of novopeptides for the treatment of cancer |
| EP4098278A1 (en) | 2014-11-13 | 2022-12-07 | The Johns Hopkins University | Checkpoint blockade and microsatellite instability |
| MA40737A (fr) * | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
| US20180133327A1 (en) * | 2015-03-16 | 2018-05-17 | Amal Therapeutics Sa | Cell Penetrating Peptides and Complexes Comprising the Same |
| US20190099475A1 (en) | 2015-04-08 | 2019-04-04 | Nantomics, Llc | Cancer neoepitopes |
| CA2988388C (en) * | 2015-04-23 | 2022-11-22 | Nantomics, Llc | Cancer neoepitopes |
| SG10201912485PA (en) | 2015-05-13 | 2020-02-27 | Agenus Inc | Vaccines for treatment and prevention of cancer |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| CA3003251A1 (en) * | 2015-10-12 | 2017-04-20 | Nantomics, Llc | Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors |
| AU2016339924B2 (en) * | 2015-10-12 | 2020-01-02 | Nantomics, Llc | Compositions and methods for viral cancer neoepitopes |
| US10339274B2 (en) * | 2015-10-12 | 2019-07-02 | Nantomics, Llc | Viral neoepitopes and uses thereof |
| EP3365000B1 (en) * | 2015-10-23 | 2020-06-10 | Novartis AG | Method of deriving a value for percent biomarker positivity for selected cells present in a field of view |
| TWI733719B (zh) | 2015-12-07 | 2021-07-21 | 美商河谷控股Ip有限責任公司 | 改善的組合物及用於新表位之病毒遞送的方法及其應用 |
| RU2729116C2 (ru) | 2015-12-16 | 2020-08-04 | Гритстоун Онколоджи, Инк. | Идентификация, производство и применение неоантигенов |
| WO2017118702A1 (en) * | 2016-01-08 | 2017-07-13 | Vaccibody As | Neoepitope rna cancer vaccine |
| US11585805B2 (en) | 2016-02-19 | 2023-02-21 | Nantcell, Inc. | Methods of immunogenic modulation |
| CA3015913A1 (en) * | 2016-02-29 | 2017-09-08 | Foundation Medicine, Inc. | Methods of treating cancer |
| JP6821693B2 (ja) | 2016-02-29 | 2021-01-27 | ジェネンテック, インコーポレイテッド | がんのための治療方法及び診断方法 |
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| DK3429618T5 (da) * | 2016-03-16 | 2024-09-16 | Amal Therapeutics Sa | Kombination af en immuncheckpoint-modulator og et kompleks som omfatter et cellepenetrerende peptid, en last og en tlr-peptidagonist til anvendelse i medicin |
| SG11201810951RA (en) * | 2016-06-10 | 2019-01-30 | Io Therapeutics Inc | Receptor selective retinoid and rexinoid compounds and immune modulators for cancer immunotherapy |
| WO2018005276A1 (en) * | 2016-06-29 | 2018-01-04 | The Johns Hopkins University | Neoantigens as targets for immunotherapy |
| DK3515476T3 (da) | 2016-09-21 | 2024-09-02 | Amal Therapeutics Sa | Fusion der omfatter et cellepenetrerende peptid, en multiepitop og en trl-peptidagnost til behandlingen af cancer |
| US11332530B2 (en) | 2016-09-23 | 2022-05-17 | Memorial Sloan Kettering Cancer Center | Determinants of cancer response to immunotherapy |
| AU2017339517B2 (en) * | 2016-10-06 | 2024-03-14 | Foundation Medicine, Inc. | Therapeutic and diagnostic methods for cancer |
| CA3045811A1 (en) | 2016-12-01 | 2018-06-07 | Nantomics, Llc | Tumor antigenicity processing and presentation |
| US11480572B2 (en) | 2016-12-16 | 2022-10-25 | Nantbio, Inc. | Live cell imaging systems and methods to validate triggering of immune response |
| WO2018132753A1 (en) * | 2017-01-13 | 2018-07-19 | Nantbio, Inc. | Validation of neoepitope-based treatment |
| WO2018136664A1 (en) | 2017-01-18 | 2018-07-26 | Ichan School Of Medicine At Mount Sinai | Neoantigens and uses thereof for treating cancer |
| WO2018146128A1 (en) * | 2017-02-07 | 2018-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Detection of kit polymorphism for predicting the response to checkpoint blockade cancer immunotherapy |
| US20200102618A1 (en) * | 2017-03-17 | 2020-04-02 | Nantomics, Llc | LIQUID BIOPSY FOR cfRNA |
| KR102775647B1 (ko) * | 2017-03-31 | 2025-03-06 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
| US12072337B2 (en) | 2017-05-30 | 2024-08-27 | Nant Holdings Ip, Llc | Circulating tumor cell enrichment using neoepitopes |
| US20200276285A1 (en) | 2017-06-02 | 2020-09-03 | Arizona Board Of Regents On Behalf Of Arizona State University | A method to create personalized cancer vaccines |
| EP3879535B1 (en) * | 2017-06-13 | 2024-12-11 | BostonGene Corporation | Systems and methods for identifying cancer treatments from normalized biomarker scores |
| US12025615B2 (en) | 2017-09-15 | 2024-07-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods of classifying response to immunotherapy for cancer |
| MX2020003204A (es) | 2017-09-20 | 2020-07-20 | Regeneron Pharma | Metodos de inmunoterapia para pacientes cuyos tumores portan una carga mutacional alta de un gen pasajero. |
| EP3688165A4 (en) | 2017-09-25 | 2021-09-29 | Nant Holdings IP, LLC | VALIDATION OF THE PRESENTATION OF NEOEPITOPES |
| KR20260039788A (ko) | 2017-10-10 | 2026-03-20 | 시애틀 프로젝트 코포레이션 | 핫스팟을 이용한 신생항원 동정 |
| US20200239577A1 (en) | 2017-10-15 | 2020-07-30 | Bristol-Myers Squibb Company | Methods of treating tumor |
| EP3704268B1 (en) | 2017-11-03 | 2025-01-22 | Guardant Health, Inc. | Normalizing tumor mutation burden |
| CA3083097A1 (en) | 2017-11-22 | 2019-05-31 | Gritstone Oncology, Inc. | Reducing junction epitope presentation for neoantigens |
| CN108009400B (zh) * | 2018-01-11 | 2018-07-06 | 至本医疗科技(上海)有限公司 | 全基因组肿瘤突变负荷预测方法、设备以及存储介质 |
| MA52363A (fr) | 2018-04-26 | 2021-03-03 | Agenus Inc | Compositions peptidiques de liaison à une protéine de choc thermique (hsp) et leurs méthodes d'utilisation |
| JP7466519B2 (ja) | 2018-07-23 | 2024-04-12 | ガーダント ヘルス, インコーポレイテッド | 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム |
| JP7539367B2 (ja) | 2018-08-31 | 2024-08-23 | ガーダント ヘルス, インコーポレイテッド | 無細胞dnaにおけるマイクロサテライト不安定性の検出 |
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| CN113194995A (zh) * | 2018-12-12 | 2021-07-30 | 免疫医疗有限责任公司 | 基于血液的肿瘤突变负荷预测非小细胞肺癌的总存活 |
| US20220081723A1 (en) * | 2018-12-21 | 2022-03-17 | Agency For Science, Technology And Research | Method of predicting for benefit from immune checkpoint inhibition therapy |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| EP4038222A4 (en) | 2019-10-02 | 2023-10-18 | Arizona Board of Regents on behalf of Arizona State University | Methods and compositions for identifying neoantigens for use in treating and preventing cancer |
| NL2024107B1 (en) * | 2019-10-26 | 2021-07-19 | Vitroscan B V | Compositions for Patient Specific Immunotherapy |
| GB202007099D0 (en) | 2020-05-14 | 2020-07-01 | Kymab Ltd | Tumour biomarkers for immunotherapy |
| US12295997B2 (en) | 2020-07-06 | 2025-05-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| EP4000595A1 (en) * | 2020-11-17 | 2022-05-25 | The Boots Company plc | Tetrapeptide and compositions comprising tetrapeptides |
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| CN110295218B (zh) * | 2018-03-22 | 2023-09-01 | 长庚医疗财团法人嘉义长庚纪念医院 | 量化靶基因的突变型等位基因负担的方法 |
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| CN111088349A (zh) * | 2020-02-14 | 2020-05-01 | 深圳市宝安区妇幼保健院 | Kir3dl1基因分型引物组及其应用 |
| CN115667550A (zh) * | 2020-03-23 | 2023-01-31 | 皇家飞利浦有限公司 | 基于免疫检查点基因对前列腺癌对象的放疗反应的预测 |
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| BR112016015399A2 (pt) | 2017-10-24 |
| US20160326597A1 (en) | 2016-11-10 |
| RU2707530C2 (ru) | 2019-11-27 |
| SG10201805674YA (en) | 2018-08-30 |
| RU2016131207A3 (https=) | 2018-06-22 |
| CL2016001708A1 (es) | 2017-03-17 |
| MX2016008771A (es) | 2016-12-20 |
| SG11201605432RA (en) | 2016-07-28 |
| JP2017504324A (ja) | 2017-02-09 |
| EP3090066A4 (en) | 2017-08-30 |
| PE20161344A1 (es) | 2016-12-23 |
| WO2015103037A2 (en) | 2015-07-09 |
| RU2016131207A (ru) | 2018-02-07 |
| WO2015103037A3 (en) | 2015-11-05 |
| CA2935214A1 (en) | 2015-07-09 |
| EP3090066A2 (en) | 2016-11-09 |
| KR20160102314A (ko) | 2016-08-29 |
| AU2014374020A1 (en) | 2016-08-18 |
| PH12016501329A1 (en) | 2016-10-03 |
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