CN106164078A - 氧可酮盐酸盐的合成 - Google Patents

氧可酮盐酸盐的合成 Download PDF

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Publication number
CN106164078A
CN106164078A CN201480075277.9A CN201480075277A CN106164078A CN 106164078 A CN106164078 A CN 106164078A CN 201480075277 A CN201480075277 A CN 201480075277A CN 106164078 A CN106164078 A CN 106164078A
Authority
CN
China
Prior art keywords
oxycodone
sulfate
hydroxycodeinone
alkali
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480075277.9A
Other languages
English (en)
Chinese (zh)
Inventor
季诺维·伊托夫
弗拉基米尔·F·库兹涅佐夫
尤里·沃伊采霍夫斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cody Laboratories Inc
Original Assignee
Cody Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/132,737 external-priority patent/US9062062B1/en
Priority claimed from US14/132,825 external-priority patent/US8846923B1/en
Priority claimed from US14/132,910 external-priority patent/US10227354B2/en
Application filed by Cody Laboratories Inc filed Critical Cody Laboratories Inc
Publication of CN106164078A publication Critical patent/CN106164078A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480075277.9A 2013-12-18 2014-12-18 氧可酮盐酸盐的合成 Pending CN106164078A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US14/132,737 2013-12-18
US14/132,737 US9062062B1 (en) 2013-12-18 2013-12-18 Synthesis of oxycodone hydrochloride
US14/132,825 US8846923B1 (en) 2013-12-18 2013-12-18 Preparation of 14-hydroxycodeinone sulfate
US14/132,910 US10227354B2 (en) 2013-12-18 2013-12-18 Conversion of oxycodone base to oxycodone hydrochloride
US14/132,910 2013-12-18
US14/132,825 2013-12-18
PCT/US2014/071264 WO2015095585A2 (fr) 2013-12-18 2014-12-18 Synthese de chlorhydrate d'oxycodone

Publications (1)

Publication Number Publication Date
CN106164078A true CN106164078A (zh) 2016-11-23

Family

ID=52293289

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480075277.9A Pending CN106164078A (zh) 2013-12-18 2014-12-18 氧可酮盐酸盐的合成

Country Status (4)

Country Link
EP (1) EP3083632A2 (fr)
CN (1) CN106164078A (fr)
CA (1) CA2934527A1 (fr)
WO (1) WO2015095585A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110770238A (zh) * 2017-06-20 2020-02-07 庄信万丰股份有限公司 用于从14-羟可待因酮制备盐酸氧可酮的氢化方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR092858A1 (es) 2012-07-16 2015-05-06 Rhodes Tech Procedimiento para una sintesis mejorada de opioide
AR091779A1 (es) 2012-07-16 2015-02-25 Rhodes Technologies Procedimiento para la sintesis mejorada de opioides
AU2015207734B2 (en) 2014-01-15 2017-02-23 Rhodes Technologies Process for improved oxymorphone synthesis
JP2017502991A (ja) 2014-01-15 2017-01-26 ローズ テクノロジーズ 改良されたオキシコドン合成のための方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011117172A1 (fr) * 2010-03-23 2011-09-29 Siegfried Ltd. Préparation d'opiates à basse teneur en impuretés dans un réacteur à flux continu
WO2014013311A1 (fr) * 2012-07-16 2014-01-23 Rhodes Technologies Procédé pour améliorer la synthèse d'opioïdes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4613668A (en) 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US6067749A (en) 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
SK286087B6 (sk) * 2004-08-18 2008-03-05 Zentiva, A. S. Spôsob prípravy oxykodonu
GB0421149D0 (en) * 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
EP1893616B1 (fr) 2005-06-16 2010-12-29 Mallinckrodt, Inc. Voie de synthese de 14-hydroxyl opiates via le 1-halo-thebaine ou des analogues

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011117172A1 (fr) * 2010-03-23 2011-09-29 Siegfried Ltd. Préparation d'opiates à basse teneur en impuretés dans un réacteur à flux continu
WO2014013311A1 (fr) * 2012-07-16 2014-01-23 Rhodes Technologies Procédé pour améliorer la synthèse d'opioïdes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110770238A (zh) * 2017-06-20 2020-02-07 庄信万丰股份有限公司 用于从14-羟可待因酮制备盐酸氧可酮的氢化方法
CN110770238B (zh) * 2017-06-20 2022-10-04 庄信万丰股份有限公司 用于从14-羟可待因酮制备盐酸氧可酮的氢化方法

Also Published As

Publication number Publication date
WO2015095585A2 (fr) 2015-06-25
CA2934527A1 (fr) 2015-06-25
EP3083632A2 (fr) 2016-10-26
WO2015095585A3 (fr) 2015-08-13
WO2015095585A8 (fr) 2016-02-04

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Application publication date: 20161123