CN106164078A - 氧可酮盐酸盐的合成 - Google Patents
氧可酮盐酸盐的合成 Download PDFInfo
- Publication number
- CN106164078A CN106164078A CN201480075277.9A CN201480075277A CN106164078A CN 106164078 A CN106164078 A CN 106164078A CN 201480075277 A CN201480075277 A CN 201480075277A CN 106164078 A CN106164078 A CN 106164078A
- Authority
- CN
- China
- Prior art keywords
- oxycodone
- sulfate
- hydroxycodeinone
- alkali
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/132,737 | 2013-12-18 | ||
US14/132,737 US9062062B1 (en) | 2013-12-18 | 2013-12-18 | Synthesis of oxycodone hydrochloride |
US14/132,825 US8846923B1 (en) | 2013-12-18 | 2013-12-18 | Preparation of 14-hydroxycodeinone sulfate |
US14/132,910 US10227354B2 (en) | 2013-12-18 | 2013-12-18 | Conversion of oxycodone base to oxycodone hydrochloride |
US14/132,910 | 2013-12-18 | ||
US14/132,825 | 2013-12-18 | ||
PCT/US2014/071264 WO2015095585A2 (fr) | 2013-12-18 | 2014-12-18 | Synthese de chlorhydrate d'oxycodone |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106164078A true CN106164078A (zh) | 2016-11-23 |
Family
ID=52293289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480075277.9A Pending CN106164078A (zh) | 2013-12-18 | 2014-12-18 | 氧可酮盐酸盐的合成 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP3083632A2 (fr) |
CN (1) | CN106164078A (fr) |
CA (1) | CA2934527A1 (fr) |
WO (1) | WO2015095585A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110770238A (zh) * | 2017-06-20 | 2020-02-07 | 庄信万丰股份有限公司 | 用于从14-羟可待因酮制备盐酸氧可酮的氢化方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR092858A1 (es) | 2012-07-16 | 2015-05-06 | Rhodes Tech | Procedimiento para una sintesis mejorada de opioide |
AR091779A1 (es) | 2012-07-16 | 2015-02-25 | Rhodes Technologies | Procedimiento para la sintesis mejorada de opioides |
AU2015207734B2 (en) | 2014-01-15 | 2017-02-23 | Rhodes Technologies | Process for improved oxymorphone synthesis |
JP2017502991A (ja) | 2014-01-15 | 2017-01-26 | ローズ テクノロジーズ | 改良されたオキシコドン合成のための方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011117172A1 (fr) * | 2010-03-23 | 2011-09-29 | Siegfried Ltd. | Préparation d'opiates à basse teneur en impuretés dans un réacteur à flux continu |
WO2014013311A1 (fr) * | 2012-07-16 | 2014-01-23 | Rhodes Technologies | Procédé pour améliorer la synthèse d'opioïdes |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4795813A (en) | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
US4613668A (en) | 1983-12-22 | 1986-09-23 | The United States Of America As Represented By The Department Of Health And Human Services | Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl |
US6067749A (en) | 1996-07-11 | 2000-05-30 | Tasmanian Alkaloids Pty. Ltd. | Papaver somniferum strain with high concentration of thebaine and oripavine |
SK286087B6 (sk) * | 2004-08-18 | 2008-03-05 | Zentiva, A. S. | Spôsob prípravy oxykodonu |
GB0421149D0 (en) * | 2004-09-23 | 2004-10-27 | Johnson Matthey Plc | Preparation of oxycodone |
EP1893616B1 (fr) | 2005-06-16 | 2010-12-29 | Mallinckrodt, Inc. | Voie de synthese de 14-hydroxyl opiates via le 1-halo-thebaine ou des analogues |
-
2014
- 2014-12-18 WO PCT/US2014/071264 patent/WO2015095585A2/fr active Application Filing
- 2014-12-18 EP EP14824727.3A patent/EP3083632A2/fr not_active Withdrawn
- 2014-12-18 CN CN201480075277.9A patent/CN106164078A/zh active Pending
- 2014-12-18 CA CA2934527A patent/CA2934527A1/fr not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011117172A1 (fr) * | 2010-03-23 | 2011-09-29 | Siegfried Ltd. | Préparation d'opiates à basse teneur en impuretés dans un réacteur à flux continu |
WO2014013311A1 (fr) * | 2012-07-16 | 2014-01-23 | Rhodes Technologies | Procédé pour améliorer la synthèse d'opioïdes |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110770238A (zh) * | 2017-06-20 | 2020-02-07 | 庄信万丰股份有限公司 | 用于从14-羟可待因酮制备盐酸氧可酮的氢化方法 |
CN110770238B (zh) * | 2017-06-20 | 2022-10-04 | 庄信万丰股份有限公司 | 用于从14-羟可待因酮制备盐酸氧可酮的氢化方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2015095585A2 (fr) | 2015-06-25 |
CA2934527A1 (fr) | 2015-06-25 |
EP3083632A2 (fr) | 2016-10-26 |
WO2015095585A3 (fr) | 2015-08-13 |
WO2015095585A8 (fr) | 2016-02-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161123 |