WO2015095585A3 - Synthese de chlorhydrate d'oxycodone - Google Patents

Synthese de chlorhydrate d'oxycodone Download PDF

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Publication number
WO2015095585A3
WO2015095585A3 PCT/US2014/071264 US2014071264W WO2015095585A3 WO 2015095585 A3 WO2015095585 A3 WO 2015095585A3 US 2014071264 W US2014071264 W US 2014071264W WO 2015095585 A3 WO2015095585 A3 WO 2015095585A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxycodone
oxycodone hydrochloride
sysnthesis
impurity
minimize
Prior art date
Application number
PCT/US2014/071264
Other languages
English (en)
Other versions
WO2015095585A2 (fr
WO2015095585A8 (fr
Inventor
Zinovy Itov
Vladimir F. KUZNETSOV
Iouri Voitsekhovski
Original Assignee
Cody Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/132,910 external-priority patent/US10227354B2/en
Priority claimed from US14/132,825 external-priority patent/US8846923B1/en
Priority claimed from US14/132,737 external-priority patent/US9062062B1/en
Application filed by Cody Laboratories, Inc. filed Critical Cody Laboratories, Inc.
Priority to CA2934527A priority Critical patent/CA2934527A1/fr
Priority to CN201480075277.9A priority patent/CN106164078A/zh
Priority to EP14824727.3A priority patent/EP3083632A2/fr
Publication of WO2015095585A2 publication Critical patent/WO2015095585A2/fr
Publication of WO2015095585A3 publication Critical patent/WO2015095585A3/fr
Publication of WO2015095585A8 publication Critical patent/WO2015095585A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des procédés de synthèse pour la préparation d'oxycodone et ses sels avec un profil d'impureté amélioré. La thébaïne est convertie en un intermédiaire de sulfate 14-hydroxycodéinone pour minimiser l'impureté de 7,8-dihydro-8,14-dihydroxycodéinone. L'invention concerne des procédés efficaces pour la conversion d'oxycodone basique en chlorhydrate d'oxycodone pour minimiser l'impureté de 14-hydroxycodéinone dans le produit final.
PCT/US2014/071264 2013-12-18 2014-12-18 Synthese de chlorhydrate d'oxycodone WO2015095585A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA2934527A CA2934527A1 (fr) 2013-12-18 2014-12-18 Synthese de chlorhydrate d'oxycodone
CN201480075277.9A CN106164078A (zh) 2013-12-18 2014-12-18 氧可酮盐酸盐的合成
EP14824727.3A EP3083632A2 (fr) 2013-12-18 2014-12-18 Synthese de chlorhydrate d'oxycodone

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14/132,910 US10227354B2 (en) 2013-12-18 2013-12-18 Conversion of oxycodone base to oxycodone hydrochloride
US14/132,825 2013-12-18
US14/132,825 US8846923B1 (en) 2013-12-18 2013-12-18 Preparation of 14-hydroxycodeinone sulfate
US14/132,910 2013-12-18
US14/132,737 US9062062B1 (en) 2013-12-18 2013-12-18 Synthesis of oxycodone hydrochloride
US14/132,737 2013-12-18

Publications (3)

Publication Number Publication Date
WO2015095585A2 WO2015095585A2 (fr) 2015-06-25
WO2015095585A3 true WO2015095585A3 (fr) 2015-08-13
WO2015095585A8 WO2015095585A8 (fr) 2016-02-04

Family

ID=52293289

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/071264 WO2015095585A2 (fr) 2013-12-18 2014-12-18 Synthese de chlorhydrate d'oxycodone

Country Status (4)

Country Link
EP (1) EP3083632A2 (fr)
CN (1) CN106164078A (fr)
CA (1) CA2934527A1 (fr)
WO (1) WO2015095585A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6236446B2 (ja) 2012-07-16 2017-11-22 ローズ テクノロジーズ 改善されたオピオイド合成方法
CN104470928B (zh) 2012-07-16 2017-08-11 罗德科技公司 用于改进的阿片样物质合成的方法
KR101868724B1 (ko) 2014-01-15 2018-06-18 로드스 테크놀로지즈 개선된 옥시모르폰 합성을 위한 방법
CN106029670A (zh) 2014-01-15 2016-10-12 罗德科技公司 改进的羟考酮合成的方法
WO2018234748A1 (fr) * 2017-06-20 2018-12-27 Johnson Matthey Public Limited Company Procédé d'hydrogénation pour la préparation de chlorhydrate d'oxycodone à partir de 14-hydroxycodéinone

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006019364A1 (fr) * 2004-08-18 2006-02-23 Zentiva, A.S. Méthode de synthèse de l’oxycodone
US20060111383A1 (en) * 2004-09-23 2006-05-25 Casner Michael L Preparation of oxycodone
WO2011117172A1 (fr) * 2010-03-23 2011-09-29 Siegfried Ltd. Préparation d'opiates à basse teneur en impuretés dans un réacteur à flux continu
WO2014013311A1 (fr) * 2012-07-16 2014-01-23 Rhodes Technologies Procédé pour améliorer la synthèse d'opioïdes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4613668A (en) 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US6067749A (en) 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
JP2008546688A (ja) 2005-06-16 2008-12-25 マリンクロッド・インコーポレイテッド １−ハロ−テバインまたは類似体を介する１４−ヒドロキシルオピエート類への合成経路

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006019364A1 (fr) * 2004-08-18 2006-02-23 Zentiva, A.S. Méthode de synthèse de l’oxycodone
US20060111383A1 (en) * 2004-09-23 2006-05-25 Casner Michael L Preparation of oxycodone
WO2011117172A1 (fr) * 2010-03-23 2011-09-29 Siegfried Ltd. Préparation d'opiates à basse teneur en impuretés dans un réacteur à flux continu
WO2014013311A1 (fr) * 2012-07-16 2014-01-23 Rhodes Technologies Procédé pour améliorer la synthèse d'opioïdes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3083632A2 *

Also Published As

Publication number Publication date
CN106164078A (zh) 2016-11-23
EP3083632A2 (fr) 2016-10-26
WO2015095585A2 (fr) 2015-06-25
WO2015095585A8 (fr) 2016-02-04
CA2934527A1 (fr) 2015-06-25

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