CN1061236C - eczema ointment - Google Patents
eczema ointment Download PDFInfo
- Publication number
- CN1061236C CN1061236C CN94119697A CN94119697A CN1061236C CN 1061236 C CN1061236 C CN 1061236C CN 94119697 A CN94119697 A CN 94119697A CN 94119697 A CN94119697 A CN 94119697A CN 1061236 C CN1061236 C CN 1061236C
- Authority
- CN
- China
- Prior art keywords
- eczema
- medicine
- gram
- rhizoma
- ointment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000004624 Dermatitis Diseases 0.000 title claims abstract description 9
- 208000010668 atopic eczema Diseases 0.000 title claims abstract description 9
- 239000002674 ointment Substances 0.000 title description 12
- 239000003814 drug Substances 0.000 claims abstract description 14
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 5
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 4
- 241000180649 Panax notoginseng Species 0.000 claims description 4
- 206010043866 Tinea capitis Diseases 0.000 claims 1
- 208000009189 tinea favosa Diseases 0.000 claims 1
- 239000006071 cream Substances 0.000 abstract description 5
- 208000003251 Pruritus Diseases 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 239000000419 plant extract Substances 0.000 abstract description 2
- 238000006748 scratching Methods 0.000 abstract description 2
- 230000002393 scratching effect Effects 0.000 abstract description 2
- 208000017520 skin disease Diseases 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 235000002566 Capsicum Nutrition 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 239000006002 Pepper Substances 0.000 abstract 1
- 235000016761 Piper aduncum Nutrition 0.000 abstract 1
- 235000017804 Piper guineense Nutrition 0.000 abstract 1
- 244000203593 Piper nigrum Species 0.000 abstract 1
- 235000008184 Piper nigrum Nutrition 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229940105847 calamine Drugs 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 229910052864 hemimorphite Inorganic materials 0.000 abstract 1
- 230000007803 itching Effects 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 235000014692 zinc oxide Nutrition 0.000 abstract 1
- 239000011787 zinc oxide Substances 0.000 abstract 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241001116389 Aloe Species 0.000 description 2
- 241001161070 Calomela Species 0.000 description 2
- 241000252229 Carassius auratus Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 235000011399 aloe vera Nutrition 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 2
- 229960004022 clotrimazole Drugs 0.000 description 2
- 229960003957 dexamethasone Drugs 0.000 description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 229960001347 fluocinolone acetonide Drugs 0.000 description 2
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229910052957 realgar Inorganic materials 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 2
- 235000021419 vinegar Nutrition 0.000 description 2
- 239000000052 vinegar Substances 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 241000972155 Moschus Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000109 continuous material Substances 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- -1 dens Chemical compound 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to an external medicine for treating skin diseases, which takes natural plant extracts as active ingredients. The eczema cream comprises the following components in percentage by weight: 2-15% of coptis root, 1-15% of radix sophorae flavescentis, 1-10% of rhizoma atractylodis, 1-20% of cortex dictamni, 1-15% of rhizoma paridis, 1-20% of pseudo-ginseng, 1-30% of calamine, 0.5-10% of pepper, 0.5-15% of borneol, 0.5-15% of liquorice and 2-30% of excipient. The medicine provided by the invention is mainly used for treating eczema caused by rheumatism and toxic heat, flush and pruritus of affected parts, exudation of saliva after scratching and the like, and has the effects of clearing heat and removing dampness, activating blood and reducing swelling, dispelling wind and relieving itching and the like.
Description
The present invention relates to the natural plant extracts is the dermopathic external used medicine of treatment of effective ingredient.
Chinese patent application CN1078396 (application number 93103020) discloses a kind of " medicine for treating dermatosis and manufacture method thereof ", it comprises Calomelas, sulfur, Realgar, Aerugo, dried Alumen, it is characterized in that: this medicine also comprises Calamina, Borneolum Syntheticum, dens, Gypsum Fibrosum powder, Mentholum, Carassius auratus frost, Semen Vignae Radiatae flour, hydroxytetracycline tablet, dexamethasone tablet, and use fluocinolone acetonide cream or relaxed and comfortable ointment of chlorine or clotrimazole ointment double as blender, their share is as follows: Calomelas 12-20 gram, sulfur 5-10 gram, Realgar 5-10 gram, Aerugo 10-20 gram, dried Alumen 3-6 gram, Calamina 20-200 gram, Borneolum Syntheticum 5-10 gram, dens 30-300 gram, Gypsum Fibrosum powder 18-180 gram, Mentholum 5-10 gram, Carassius auratus frost 5-10 gram, Semen Vignae Radiatae flour 10-500 gram, hydroxytetracycline tablet 3-6 gram, dexamethasone tablet 2-4 gram, and fluocinolone acetonide cream or halcinonidedcorten ointment or clotrimazole ointment 1300-5000 gram.
Chinese patent application CN1021305 (application number 87102282) discloses a kind of " production method of eczema medicine ", it is characterized in that: a, the root that will contain the plant of three Saponins, stem, leaf and the root of plant that contains berberine are by 1: 9-1: in the time of 1 4-7 times, seethed with excitement 5-0 minute, when spissated amount is 0.5-1 times of drug weight, can be used as decoct uses, b, get concentrated solution 1 part (weight) and add water 10-20 doubly, heating bath can be treated the erythra of general, c, with the medicine after smashing to pieces, grind to form fine powder, promptly become powder, add bright boiled water insulation subsequently and soak, take to soak and use, d, ground powder and medicinal vaseline are pressed 3: 7-4: the mixed of 8 (weight ratios), the cream system of making stirs.
Chinese patent application CN1075652 (application number 93102292) discloses a kind of " Chinese medicine preparation of treatment dermatopathy and preparation method thereof ", it is characterized in that: this 100 weight portion Chinese medicine preparation is that Herba Portulacae, Aloe, Herba Mimosae Pudicae, Folium Artemisiae Argyi, Moschus and tablet vinegar are formed, its percentage by weight is Herba Portulacae 2-2.5, Aloe 2-2.2, Herba Mimosae Pudicae 0.25-0.5, Folium Artemisiae Argyi 0.1-0.225, all the other are tablet vinegar for fan 0.001-0.005.
Purpose of the present invention aims to provide a kind of removing damp-heat, promoting blood circulation and detumescence, is used for the treatment of dermopathic external preparation.
Eczema ointment of the present invention is grouped into (percentage by weight) by following one-tenth: Rhizoma Coptidis 2-15%, Radix Sophorae Flavescentis 1-15%, Rhizoma Atractylodis 1-10%, Cortex Dictamni 1-20%, Rhizoma Paridis 1-15%, Radix Notoginseng 1-20%, Calamina 1-30%, Pericarpium Zanthoxyli 0.5-10%, Borneolum Syntheticum 0.5-15%, Radix Glycyrrhizae 0.5-15%, excipient 2-30% make pharmaceutically receivable external preparation.
Medicine of the present invention cures mainly because of the eczema due to the rheumatism pyretic toxicity, and affected part flushing, pruritus are oozed out diseases such as Jin Shui after scratching, has removing damp-heat, promoting blood circulation and detumescence, effect such as dispelling wind is antipruritic can be made into multiple exterior-applied formulations such as ointment, cream, ointment, ointment, wet unguentum.Through the materia medica test, this eczema ointment has no side effect to human body, and pathogen growth and breeding are had better inhibitory action.
Embodiment:
Get Rhizoma Coptidis 80g, Radix Sophorae Flavescentis 60g, Rhizoma Atractylodis 60g, Cortex Dictamni 100g, Rhizoma Paridis 100g, Pericarpium Zanthoxyli 30g, Radix Glycyrrhizae 80g breaks into coarse powder, adds five times of water logging bubbles one hour, boils one hour, filters, and repeatedly for several times, merges leach cooking liquid, is concentrated into the about qdx of crude drug, uses.
Get Calamina 30g, Radix Notoginseng 50g, Borneolum Syntheticum 30g beats powder respectively, and it is standby to cross 100 orders.
Heating adds excipient caustic potash in above-mentioned Chinese medicine concentrated solution, triethanolamine, ethanol, make its dissolving, in addition excipient stearic acid, glycerol, newborn wax, white oil etc. are heated to and slowly pour above-mentioned aqueous phase about 90 ℃ into, simultaneously continuous material controlling makes emulsifying, add Calamina, Radix Notoginseng, Borneolum Syntheticum fine powder again, mixing gets final product.
Can add an amount of essence or antiseptic.
Claims (1)
1, a kind of medicine for the treatment of eczema, it is characterized in that it being to make: Rhizoma Coptidis 2-15%, Radix Sophorae Flavescentis 1-15% by following weight percentages, Rhizoma Atractylodis 1-10%, favus skin 1-20%, Rhizoma Paridis 1-15%, Radix Notoginseng 1-20%, Calamina 1-30%, Pericarpium Zanthoxyli 0.5-10%, Borneolum Syntheticum 0.5-15%, Radix Glycyrrhizae 0.5-15%, excipient 2-30%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94119697A CN1061236C (en) | 1994-12-22 | 1994-12-22 | eczema ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94119697A CN1061236C (en) | 1994-12-22 | 1994-12-22 | eczema ointment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1125117A CN1125117A (en) | 1996-06-26 |
| CN1061236C true CN1061236C (en) | 2001-01-31 |
Family
ID=5039342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94119697A Expired - Fee Related CN1061236C (en) | 1994-12-22 | 1994-12-22 | eczema ointment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1061236C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066958C (en) * | 1998-08-27 | 2001-06-13 | 郇宜君 | antipruritic aerosol |
| JP4294495B2 (en) * | 2002-04-15 | 2009-07-15 | 哲夫 山東 | Dermatitis treatment |
| CN101019952B (en) * | 2006-11-20 | 2011-01-12 | 深圳市北科联药业科技有限公司 | Medicine for treating eczema and preparation process of its ointment |
| CN105943795A (en) * | 2016-06-22 | 2016-09-21 | 朱明浩 | Traditional Chinese medicine composition for treating eczema and neurodermatitis, external preparation as well as preparation method and application thereof |
| CN106362049A (en) * | 2016-10-14 | 2017-02-01 | 柳州环山科技有限公司 | Pure traditional Chinese medicine composition for eczema treatment and preparation method thereof |
| CN115300574A (en) * | 2022-06-24 | 2022-11-08 | 朱明浩 | Application of eczema ointment containing seven kinds of ginseng and coptis in preparation of medicine for treating neurodermatitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1062287A (en) * | 1990-12-11 | 1992-07-01 | 沈慧衷 | " an unusually sweet smell powder " compositions and preparation method |
| CN1074114A (en) * | 1992-12-15 | 1993-07-14 | 杨武发 | Medical bathing powder for relieving fatigue and preparation technology thereof |
-
1994
- 1994-12-22 CN CN94119697A patent/CN1061236C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1062287A (en) * | 1990-12-11 | 1992-07-01 | 沈慧衷 | " an unusually sweet smell powder " compositions and preparation method |
| CN1074114A (en) * | 1992-12-15 | 1993-07-14 | 杨武发 | Medical bathing powder for relieving fatigue and preparation technology thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《陕西中医》(2) 1989.2.28 贾佐缠湿疹216例 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1125117A (en) | 1996-06-26 |
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| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |