CN1066958C - antipruritic aerosol - Google Patents
antipruritic aerosol Download PDFInfo
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- CN1066958C CN1066958C CN98112946A CN98112946A CN1066958C CN 1066958 C CN1066958 C CN 1066958C CN 98112946 A CN98112946 A CN 98112946A CN 98112946 A CN98112946 A CN 98112946A CN 1066958 C CN1066958 C CN 1066958C
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Abstract
The present invention relates to an antipruritic aerosol used for treating skin pruritus, which is composed of the extracts of Chinese medicines, 75% ethanol, and a propellent 114, wherein the Chinese medicines comprise pricklyash peel, lightyellow sophora root, common cnidium fruit and dittany. The medicine of the present invention has the advantages of short course of the treatment, obvious effect, conspicuous curative effect, portability, easy use, no pollution of clothing, etc., which is proved by 196 cases of the clinical observation experiments of Xi'a 141 hospital. The cure rate of the present invention is 77.2%, and the total effective rate is 98.5%. The experiments of the present invention can be further expanded in clinic.
Description
The invention belongs to contain raw material or with the medicinal preparation technical field of the product of not clear structure, be specifically related to derive from the material of plant.
Skin pruritus is common clinically a kind of dermatosis, and the main cause of morbidity is that polyphagia delicious food savoury and hot perfume (or spice) are processed rich product and mind agitation, or because of the natural environment variation, and the trouble skin pruritus, during sick sending out, lesions position is itched, the patient feels to be difficult to be subjected to, even can not sleep all night.
The medicine for the treatment of skin pruritus clinically has oral medicine and medicine for external use, and oral medicine patient medicine time, short curative effect was not remarkable, and medicine time, length had infringement to Liver and kidney.External used medicine has fluocinonide ointment etc., and fluocinonide ointment is found that there is long, slow, the shortcoming such as curative effect is low that the takes effect course of treatment in it, and is easy to pollute clothes and bedding in clinical use.
The objective of the invention is to carry and external used medicine easy to use for skin pruritus provides a kind of short treating period, instant effect, evident in efficacy.
For achieving the above object, it is extract by Pericarpium Zanthoxyli, Radix Sophorae Flavescentis, Fructus Cnidii, Cortex Dictamni for the solution that the present invention adopts, and 75% ethanol, propellant 114 forms, and the raw material dose that contains in wherein every 250ml medicinal liquid is:
Pericarpium Zanthoxyli 30～80g Radix Sophorae Flavescentis 50～100g
Fructus Cnidii 50～100g Cortex Dictamni 50～100g
75% ethanol adds to 100ml
Propellant 114 150ml
The proportion optimization weight proportion scope of preparation medicine of the present invention is:
Pericarpium Zanthoxyli 30～60g Radix Sophorae Flavescentis 50～80g
Fructus Cnidii 50～80g Cortex Dictamni 50～80g
75% ethanol adds to 100ml
Propellant 114 150ml
Above-mentioned each component is made medicine production method of the present invention is:
1. pre-treatment of raw material
Choose the decontamination and the part of going mouldy, the quality of the raw material of Chinese medicine selected for use is checked, weigh by proportioning by Chinese Pharmacopoeia.
2. extract
Pressing percolation extracts.
To mix by Pericarpium Zanthoxyli, Radix Sophorae Flavescentis, Fructus Cnidii, the Cortex Dictamni raw material of Chinese medicine that proportioning takes by weighing, put into vessel, the ethanol of adding 75% soaked 24 hours to soaking the Chinese medicine raw material, elimination medicinal residues, filtrate distillation are reclaimed ethanol to 100ml, and it is standby that medicinal liquid is put into refrigerator.
3. quality examination
Quality standard according to medicinal aerosol of the present invention is tested.
4. packing
The every bottle of 8ml medicinal liquid of packing into earlier reinstalls the 12ml propellant, seals.
The present invention is the routine clinical observations test of 141 hospitals 196 through Xi'an, prove it have short treating period, instant effect, evident in efficacy, carry and easy to use, advantage such as pollution clothes not, further expanding test clinically.
In order to prove the therapeutic effect of medicine of the present invention to skin pruritus, the inventor entrusts Xi'an 141 hospital's department ofs Chinese medicine to carry out 196 routine clinical observation tests medicine of the present invention, and test situation is as follows.
1. case is selected
Skin pruritus 196 examples, all from the outpatient, male's 107 examples wherein, women's 89 examples, 5 years old of age minimum, maximum 77 years old, 5～10 years old 32 example, 11～20 years old 31 example, 21～50 years old 66 example, 51～77 years old 67 example, the course of disease is the shortest 1 day, and is the longest 8 years.Diagnosis only has pruritus, and does not have erythra according to medical history when just sending out, can make a definite diagnosis, and the skin pruritus patient who makes a definite diagnosis is divided into drug test group of the present invention and fluocinonide ointment matched group, and test group 136 examples contrast 60 examples.
2. trial drug
The test group antipruritic aerosol, the matched group fluocinonide ointment.
3. Therapeutic Method
Test group: every day, early, middle and late lesions position the patient sprayed a medicine of the present invention, till spraying is measured and is covered lesions position to medicinal liquid, seven days is a course of treatment, and the 3rd day, the 7th day observed and recorded curative effect do not used other for oral administration and external used medicine during the treatment.
Matched group: every day, early, middle and late lesions position the patient was coated with fluocinonide ointment once, and the dose that at every turn is coated with to medicine covers till the lesions position, and seven days is a course of treatment, the 3rd day, the 7th day observed and recorded curative effect.Do not use other for oral administration and external used medicine during the treatment.
4. efficacy assessment standard
(1) recovery from illness: no scratchiness, skin lesion disappears fully.
(2) produce effects: pruritus obviously alleviates, and skin lesion disappears more than 60%.
(3) effective: pruritus alleviates, and skin lesion disappears 30～60%.
(4) invalid: pruritus with treatment before or aggravation, skin lesion disappears＜30%.
5. result of the test
Result of the test sees the following form:
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate | ||||
| The people | ％ | The people | ％ | The people | ％ | The people | ％ | |||
| Test group | 136 | ?105 | 77.2 | ?20 | ?14.7 | ?9 | ?6.6 | ?2 | ?1.5 | ?98.5％ |
| Matched group | 60 | ?31 | 51.7 | ?13 | ?21.7 | ?7 | ?11.7 | ?9 | ?15 | ?85％ |
Test statistics shows the therapeutic test that medicine of the present invention is done 136 routine patients, and cure rate is 77.2%, and total effective rate is 98.5%, learns by statistics and handles P＜0.01, and marked difference is arranged.
To further illustrate the present invention in following examples, these embodiment only are used to the present invention is described and to the present invention without limits.
The used raw material dose of embodiment 1 (product 250ml of the present invention is an example with production) is:
Pericarpium Zanthoxyli 30g Radix Sophorae Flavescentis 50g
Fructus Cnidii 50g Cortex Dictamni 50g
75% ethanol adds to 100ml
The used raw material dose of propellant 114 150ml embodiment 2 (product 250ml of the present invention is an example with production) is:
Pericarpium Zanthoxyli 45g Radix Sophorae Flavescentis 65g
Fructus Cnidii 65g Cortex Dictamni 65g
75% ethanol adds to 100ml
The used raw material dose of propellant 114 150ml embodiment 3 (is example with production 250ml product of the present invention) is:
Pericarpium Zanthoxyli 60g Radix Sophorae Flavescentis 80g
Fructus Cnidii 80g Cortex Dictamni 80g
75% ethanol adds to 100ml
Propellant 114 150ml
Claims (2)
1. antipruritic aerosol that is used for the treatment of skin pruritus is characterized in that it is to add 75% ethanol to soaking raw material of Chinese medicine by following traditional Chinese medicine raw and proportioning thereof, reclaims ethanol to 100ml, adds 150ml propellant 114 and makes the 250ml medicinal liquid:
Pericarpium Zanthoxyli 30～80g Radix Sophorae Flavescentis 50～100g
Fructus Cnidii 50～100g Cortex Dictamni 50～100g.
2. according to the described antipruritic aerosol that is used for the treatment of skin pruritus of claim 1, wherein the weight proportion of each raw material of Chinese medicine medicine is:
Pericarpium Zanthoxyli 30～60g Radix Sophorae Flavescentis 50～80g
Fructus Cnidii 50～80g Cortex Dictamni 50～80g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98112946A CN1066958C (en) | 1998-08-27 | 1998-08-27 | antipruritic aerosol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98112946A CN1066958C (en) | 1998-08-27 | 1998-08-27 | antipruritic aerosol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1246344A CN1246344A (en) | 2000-03-08 |
| CN1066958C true CN1066958C (en) | 2001-06-13 |
Family
ID=5222733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98112946A Expired - Fee Related CN1066958C (en) | 1998-08-27 | 1998-08-27 | antipruritic aerosol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1066958C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101176762B (en) * | 2007-08-20 | 2010-12-01 | 赵园方 | Lotion capable of neutralizing mosquito poison and relieving itching as well as detumescence |
| CN103285122B (en) * | 2013-06-13 | 2015-03-04 | 金品红 | Traditional Chinese medicine composition for treating swine mange and scab and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110152A (en) * | 1994-04-04 | 1995-10-18 | 邓锦煌 | Ziying lotion |
| CN1125117A (en) * | 1994-12-22 | 1996-06-26 | 昆明市火炬科技开发实业公司 | eczema ointment |
-
1998
- 1998-08-27 CN CN98112946A patent/CN1066958C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110152A (en) * | 1994-04-04 | 1995-10-18 | 邓锦煌 | Ziying lotion |
| CN1125117A (en) * | 1994-12-22 | 1996-06-26 | 昆明市火炬科技开发实业公司 | eczema ointment |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1246344A (en) | 2000-03-08 |
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