CN1839927A - Chinese traditional medicine for treating orthopaedic diseases and its preparation process - Google Patents

Abstract

The invention discloses a prepared traditional Chinese medicinal preparation for treating orthopaedic diseases, which is prepared from the raw materials of Chinese angelica root 5-20 parts, drynaria 5-15 parts, myrrh 1-8 parts, safflower 1-10 parts, tortoise shell 2-5 parts, cucumber seeds 1-20 parts, dipsacus root 5-15 parts, frank incense 1-3 parts and mahonia stem 5-25 parts through the steps of grinding, mixing homogeneously and sieving.

Description

A kind of Chinese patent medicine for the treatment of orthopaedic disease and preparation method thereof

(1) technical field: the present invention relates to Chinese patent drug technique field, relate in particular to a kind of Chinese patent medicine that is used for the treatment of orthopaedic disease and preparation method thereof.

(2) background technology: at present, fracture is a kind of common orthopaedic disease that wound causes of drawing, at present the Therapeutic Method of doctor trained in Western medicine has: Gypsum Fibrosum, wear fixing meanss such as draw point, steel plate, adopt Therapeutic Method such as fluid infusion, anti-inflammatory analgetic, the patient is not only painful big, and treatment time is long, and the patient need lie in bed 40-50 days, and side effect is big.In more than hundred million to adopt external applications be main, oral medicine is the Therapeutic Method of assisting, mostly medicine time long, it is slow to take effect, curative effect is very not remarkable, the patient suffering is big, side effect is many, cure rate is not very good and recur, and easily stays sequela, patient economy burden is big.

(3) summary of the invention: the object of the present invention is to provide a kind of dosage little, short treating period, evident in efficacy and do not recur, patient's no pain has no side effect, Chinese patent medicine of the treatment orthopaedic disease that cost is low and preparation method thereof.

Purpose of the present invention can reach by following measure: a kind of Chinese patent medicine for the treatment of orthopaedic disease, it is characterized in that calculating according to components by weight percent, it is formulated that raw material consists of Radix Angelicae Sinensis 5-20 part, Rhizoma Drynariae 5-15 part, Myrrha 1-8 part, Flos Carthami 1-10 part, Carapax et Plastrum Testudinis 2-5 part, seed of Fructus Cucumidis sativi 1-20 part, Radix Dipsaci 5-15 part, Olibanum 1-3 part, BANLIANGQIAN 0.2-1 part, Ramulus Sambuci Williamsii 5-25 part.

Realize that a kind of scheme preferably of the present invention is: calculate according to components by weight percent, it is formulated that raw material consists of 15 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Drynariae, 5 parts of Myrrhas, 5 parts on Flos Carthami, 3 parts of Carapax et Plastrum Testudiniss, 10 parts of seed of Fructus Cucumidis sativi, 10 parts of Radix Dipsacis, 2 parts of Olibanums, 0.8 part of BANLIANGQIAN, 15 parts of Ramulus Sambuci Williamsii.

A kind of Chinese patent medicine for the treatment of orthopaedic disease of the present invention, technology is made medicine is made powder routinely.

A kind of preparation method for the treatment of the Chinese patent medicine of orthopaedic disease is characterized in that it comprises the steps:

A, with Radix Angelicae Sinensis, Rhizoma Drynariae, Flos Carthami, Carapax et Plastrum Testudinis, seed of Fructus Cucumidis sativi, Radix Dipsaci, Ramulus Sambuci Williamsii be ground into respectively the end standby;

B, with Myrrha, Olibanum add respectively 2-3 sheet Concha be ground into the end standby;

C, with BANLIANGQIAN carry out that fire is forged, behind the quench in vinegar 49 times, it is standby to be ground into the end;

D, with the said medicine mix homogeneously, after sieving routinely technology make powder, pack.

The present invention adopts the following principles of formulating prescriptions: activating blood circulation to dissipate blood stasis, dredge the meridian passage, the half-cooked length of accelerated bone.

Be the effect of Chinese herbal medicine of the present invention below:

Radix Angelicae Sinensis: the sweet in the mouth suffering, warm in nature, return liver heart spleen channel, have enrich blood, invigorate blood circulation, the effect of pain relieving, loosening bowel to relieve constipation.

Rhizoma Drynariae: bitter in the mouth, warm in nature, return the Liver and kidney warp, the kidney invigorating is arranged, invigorate blood circulation, stop blooding, continue the effect of hindering.

Myrrha: bitter in the mouth, warm in nature flat, GUIXIN liver spleen channel, have invigorate blood circulation, the effect of pain relieving, detumescence and promoting granulation.

Flos Carthami: acrid in the mouth, warm in nature, the GUIXIN Liver Channel, have invigorate blood circulation, blood stasis dispelling, the effect of stimulating the menstrual flow.

Carapax et Plastrum Testudinis: sweet-salty, warm in nature, return kidney liver heart channel, nourishing YIN for suppressing the hyperactive YANG, replenishing kidney and strengthening bone are arranged, the effect of the reinforcing the heart of nourishing blood.

Seed of Fructus Cucumidis sativi: the sour in the mouth hardship, property is flat, the bones and muscles pain contraction is arranged, the effect that blood stasis is had a pain.

Radix Dipsaci: bitter in the mouth, sweet, hot, warm in nature, return the Liver and kidney warp, the effect of the kidney invigorating, promoting the circulation of blood arteries and veins, reunion of bone, traumatic injury is arranged.

Olibanum: the acrid in the mouth hardship, warm in nature, GUIXIN liver spleen channel has promoting blood circulation and stopping pain, the effect of detumescence and promoting granulation.

BANLIANGQIAN: acrid in the mouth, property is flat, and the effect of treatment traumatic injury is arranged.

Ramulus Sambuci Williamsii: sweet-bitter flavor has the effect of rolling over wound, reuniting the fractured tendons and bones.

The test example

(1) animal toxicity test

1, acute toxicity test:

Oral medication:

1. getting medicine 10g of the present invention adds water and grinds and to make full dose become the homogenate of 100ml standby.

2. get 20 of white mice (each 10 of male and female), every white mice is irritated stomach 2 times with above-mentioned standby homogenate every day, each 1.0ml, accumulated dose 2.0ml, observed 5 days, all healthy existence of white mice does not have any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively.

Conclusion: this product, is equivalent to clinical adult and estimates more than 15 times of consumption more than 10g/kg the oral dosis tolerata of white mice.

2, accumulation toxicity test

1. getting medicine 10g of the present invention adds water and grinds and to make full dose become the homogenate of 100ml standby.

2. get 30 of rat (each 15 of male and female), divide three dosage groups, the rat picked at random is divided into three groups, every group 10 (male and female each 5), every of every day observed 30 days respectively with above-mentioned standby filtrate filling stomach 1.0ml, 0.5ml, 0.25ml, the all healthy existence of rat, do not have any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively.Substantially do not have in the body and accumulate, 30 days cumulant of rat is 15 times of dosis tolerata, and does not have in the rat body and accumulate.

Conclusion: Chinese patent medicine of the present invention proves the rat accumulation toxicity test, Chinese patent medicine of the present invention do not have accumulate, nontoxic, without any side effects.

(2) clinical trial:

The present invention is formulated by Chinese crude drug, is the oral medicine of treatment bone fracture disease, and the applicant has treated the patient of 118 examples so far with this medicine in February, 2000, patient age 17-72 year, 17-40 year 76 examples wherein, 40-60 year 38 examples, 4 examples more than 60 years old, the course of disease is the shortest 4 hours, the course of disease is the longest to be 2 years, and treatment time is the shortest 13 days, the longest 45 days, clinical efficacy is remarkable, now is reported as follows:

Clinical data:

Processing: Radix Angelicae Sinensis, Rhizoma Drynariae, Flos Carthami, Carapax et Plastrum Testudinis, seed of Fructus Cucumidis sativi, Radix Dipsaci, Ramulus Sambuci Williamsii are ground into the end respectively; Myrrha, Olibanum are added 2-3 sheet Concha respectively be ground into the end; BANLIANGQIAN is carried out that fire is forged, behind the quench in vinegar 49 times, is ground into the end; With the said medicine mix homogeneously, after sieving routinely technology make powder.

Usage: get above-mentioned Chinese patent medicine 10g at every turn, use cold water after meal, morning, noon and afternoon every day respectively once.

Data shows: 30 examples of sampling, and male's 20 examples wherein, women's 10 examples wherein mostly are fracture patient, and serious comminuted fracture patient is also arranged.

Parameters for observation on effect: observe the variation of conditions of patients, the elimination of disease and administration time;

Therapeutic evaluation:

Fracture can be movable after 15 days in medication, and what basic healing was checked in film making is effective; The activity of fracture energy can be participated in normal work life freely, and what make film the inspection healing is produce effects; Fracture is inactive, for invalid;

Sum up: above-mentioned sampling 30 examples, wherein effective 30 examples account for 100%; Produce effects 28 examples account for 93.3%; Invalid is 0.

Discuss: patients such as fracture, bone splits, comminuted fracture mostly are the disorganization that burst accident causes, untimely treatment easily stays sequela, bring great misery and trouble for the later work life of patient; The present invention has relaxing muscles and tendons to promote blood circulation, eliminating stasis to stop pain, activating blood circulation to dissipate blood stasis, and dredge the meridian passage, anti-inflammatory analgetic, reinforcing the kidney to strengthen the bone, continuous dish are cured the wound, the effect of hemostasia and promoting granulation, synthetism, can reach mitigation to symptom in the short time, and fracture is had fabulous curative effect.

Model case:

Example 1: Wang Yuannian, man, 53 years old, South Mountain, Longkou City group Diao Ya people from village.When cycle to work in 2000, fall down, / 3rd comminuted fracture on the lower limb fibula of a left side, the household in time delivers to North Sea hospitalize to the patient, determine the fibula comminuted fracture through hospital's film making, the doctor gives whole bone, and planter cast is fixed, and the doctor advises patient's hospitalization, the patient does not have ability to hand over cost of hospitalization, treatment cost, do not want to be in hospital, the family members is assisting in and is going home to rest, and evening, the patient lied on a bed pain unbearably, several tablet for alleviating pain have been eaten, also lose effect, second is assisting here in once the bright family members of allowing everyday treats pain relief after taking medicine 30 minutes in here, Gypsum Fibrosum is taken away after taking medicine 3 days, lean on crutches and walk down, after taking medicine 7 days, throwing away crutches can be movable voluntarily, take medicine and fully recovered cycle to work in 15 days.

Example 2: Li Jiaqiang, the man, 46 years old, doctor Huang Cheng people from sub-district, Longkou City, April calendar year 2001, because of the right lower limb Fracture of femur of traffic accident, hospital reaches the treatment in 1 year through Wendeng City's orthopaedics, changes steel plate therebetween one time, all the time can not throw away the crutches walking, arrive here in May, 2003, treatment is taken medicine to lean in 10 days and is singly turned walking, takes the recovery from illness in 30 days of this medicine.

Example 3: history times good fortune, the man, 26 years old, the Qi Jiazhen historian village, Longkou City people from village, get into an accident on November 10th, 2003, determine bridge of the nose bone fracture through the film making of North Sea hospital, outward appearance is subsided, hospitalization cost height and unsatisfactory curative effect, took this medicine November 15, the inspection of making film to the People's Hospital in 5 days of taking medicine recovers substantially through diagnosis, takes the recovery from illness in 13 days of this medicine.

Example 4: first refined quick, the woman, 66 years old, Laishan District, Yantai City tree of heaven haze people from village, anklebone fracture is sent to tame orthopaedics commune hospital just, Yantai City inside and outside in June, 2005 right crus of diaphragm, the inside and outside anklebone fracture of right crus of diaphragm is determined in film making, doctor's suggestion operative treatment of being in hospital, doctor's prompting as not hospitalization (operation) hinder lower limb may the maimed person, through taking after this medicine treatment took medicine one hour, painless, the activity down in 7 days of taking medicine is taken medicine and was fully recovered in 20 days.

(4) specific embodiment: following the specific embodiment of the present invention is elaborated:

Embodiment 1: accurately take by weighing Radix Angelicae Sinensis 5g, Rhizoma Drynariae 5g, Myrrha 1g, Flos Carthami 1g, Carapax et Plastrum Testudinis 2g, seed of Fructus Cucumidis sativi 1g, Radix Dipsaci 5g, Olibanum 1g, BANLIANGQIAN 0.2g, Ramulus Sambuci Williamsii 5g, Radix Angelicae Sinensis, Rhizoma Drynariae, Flos Carthami, Carapax et Plastrum Testudinis, seed of Fructus Cucumidis sativi, Radix Dipsaci, Ramulus Sambuci Williamsii are ground into the end respectively; Myrrha, Olibanum are added 2 Conchas respectively be ground into the end; BANLIANGQIAN is carried out that fire is forged, behind the quench in vinegar 49 times, is ground into the end; With the said medicine mix homogeneously, after sieving routinely technology make powder, pack.

Embodiment 2: accurately take by weighing Radix Angelicae Sinensis 15g, Rhizoma Drynariae 10g, Myrrha 5g, Flos Carthami 5g, Carapax et Plastrum Testudinis 3g, seed of Fructus Cucumidis sativi 10g, Radix Dipsaci 10g, Olibanum 2g, BANLIANGQIAN 0.8g, Ramulus Sambuci Williamsii 15g, Radix Angelicae Sinensis, Rhizoma Drynariae, Flos Carthami, Carapax et Plastrum Testudinis, seed of Fructus Cucumidis sativi, Radix Dipsaci, Ramulus Sambuci Williamsii are ground into the end respectively; Myrrha, Olibanum are added 3 Conchas respectively be ground into the end; BANLIANGQIAN is carried out that fire is forged, behind the quench in vinegar 49 times, is ground into the end; With the said medicine mix homogeneously, after sieving routinely technology make powder and pack.

Embodiment 3: accurately take by weighing Radix Angelicae Sinensis 20g, Rhizoma Drynariae 15g, Myrrha 8g, Flos Carthami 10g, Carapax et Plastrum Testudinis 5g, seed of Fructus Cucumidis sativi 20g, Radix Dipsaci 15g, Olibanum 3g, BANLIANGQIAN 1g, Ramulus Sambuci Williamsii 25g, Radix Angelicae Sinensis, Rhizoma Drynariae, Flos Carthami, Carapax et Plastrum Testudinis, seed of Fructus Cucumidis sativi, Radix Dipsaci, Ramulus Sambuci Williamsii are ground into the end respectively; Myrrha, Olibanum are added 2-3 sheet Concha respectively be ground into the end; BANLIANGQIAN is carried out that fire is forged, behind the quench in vinegar 49 times, is ground into the end; With the said medicine mix homogeneously, after sieving routinely technology make powder, pack.

Claims (4)

1, a kind of Chinese patent medicine for the treatment of orthopaedic disease, it is characterized in that calculating according to components by weight percent, it is formulated that raw material consists of Radix Angelicae Sinensis 5-20 part, Rhizoma Drynariae 5-15 part, Myrrha 1-8 part, Flos Carthami 1-10 part, Carapax et Plastrum Testudinis 2-5 part, seed of Fructus Cucumidis sativi 1-20 part, Radix Dipsaci 5-15 part, Olibanum 1-3 part, BANLIANGQIAN 0.2-1 part, Ramulus Sambuci Williamsii 5-25 part.

2, a kind of Chinese patent medicine for the treatment of orthopaedic disease according to claim 1, it is characterized in that calculating according to components by weight percent, it is formulated that raw material consists of 15 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Drynariae, 5 parts of Myrrhas, 5 parts on Flos Carthami, 3 parts of Carapax et Plastrum Testudiniss, 10 parts of seed of Fructus Cucumidis sativi, 10 parts of Radix Dipsacis, 2 parts of Olibanums, 0.8 part of BANLIANGQIAN, 15 parts of Ramulus Sambuci Williamsii.

3, a kind of Chinese patent medicine for the treatment of orthopaedic disease according to claim 1 and 2 is characterized in that described medicine is a powder.

4, the described a kind of preparation method for the treatment of the Chinese patent medicine of orthopaedic disease of claim 1 is characterized in that it comprises the steps:

A, with Radix Angelicae Sinensis, Rhizoma Drynariae, Flos Carthami, Carapax et Plastrum Testudinis, seed of Fructus Cucumidis sativi, Radix Dipsaci, Ramulus Sambuci Williamsii be ground into respectively the end standby;

B, with Myrrha, Olibanum add respectively 2-3 sheet Concha be ground into the end standby;

C, with BANLIANGQIAN carry out that fire is forged, behind the quench in vinegar 49 times, it is standby to be ground into the end;

D, with the said medicine mix homogeneously, after sieving routinely technology make powder, pack.