CN1876066A - A medicine for treating impotence and preparation method thereof - Google Patents
A medicine for treating impotence and preparation method thereof Download PDFInfo
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- CN1876066A CN1876066A CNA2006100108312A CN200610010831A CN1876066A CN 1876066 A CN1876066 A CN 1876066A CN A2006100108312 A CNA2006100108312 A CN A2006100108312A CN 200610010831 A CN200610010831 A CN 200610010831A CN 1876066 A CN1876066 A CN 1876066A
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Abstract
The invention relates to a pharmaceutical composition for treating impotence and process for preparation, wherein the active constituents include hairy deerhorn, curculigo rhizome, broomrape, leek seeds, Chinese angelica root, gen-seng, psoralea fruit, dodder seed, cnidium fruit and epimeddium.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of sexual impotence and preparation method thereof.
Background technology
Sexual impotence is a kind of common andropathy, typically refer to male penis anorthosis or penis under sex drive and sexual intercourse requirement and can only erect but can not keep enough hardness, so that penis can not be inserted vagina or be inserted intravaginal deliquescing soon during sexual intercourse.With the quickening pace of modern life, " sexual life is inharmonious " that problem such as excessive and drug abuse causes owing to pressure is the trend that rises year by year.According to incompletely statistics, in China's adult male, there is 10% people that the sexual impotence performance is arranged approximately, has 38% divorce case to be caused approximately by the healthy reproduction problem relevant with sexual impotence.How to treat the quality of sexual impotence, concern men's health, raising sexual life effectively, be not only medical care problem, and become a social problem that receives much concern.At present, though the medicine of treatment sexual impotence is a lot, also exist the course of treatment long, uncertain therapeutic efficacy is cut, side effect more greatly, easily forms problems such as drug dependence.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, the Chinese medicine composition of remarkable, the safe and reliable treatment sexual impotence of a kind of effect is provided.
The present invention also aims to provide a kind of preparation method of described Chinese medicine composition.
Purpose of the present invention is achieved by following technical proposals.
☆ except as otherwise noted, the percent that is adopted among the present invention is percetage by weight.
Medicament selection Cornu Cervi Pantotrichum of the present invention, Rhizoma Curculiginis, Herba Cistanches, Semen Allii Tuberosi, Radix Ginseng, Fructus Psoraleae, Radix Angelicae Sinensis, Semen Cuscutae, Fructus Cnidii and Herba Epimedii make up.Wherein Cornu Cervi Pantotrichum, Radix Ginseng, Herba Cistanches and Herba Epimedii are the medicine of reinforcing the kidney and supporting YANG, " Cornu Cervi Pantotrichum " nature and flavor are salty, temperature, warming the kidney to activate YANG, astringing to arrest bleeding, body there is strong effect, can quickens liver, kidney, brain tissue metabolism, promote the generation of erythrocyte, hemoglobin, promote skein cell new life, quicken lymhocyte transformation rate, human body immunity improving function, physical strength reinforcing and ability to work etc.Sweet, the little hardship of " Radix Ginseng " nature and flavor, flat, return spleen, lung, heart channel, the energy strongly invigorating primordial QI, multiple arteries and veins takes off invigorating the spleen to benefit the lung admittedly, promote the production of body fluid, calm the nerves, the clinical weak body and prostration that is used for, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, Tianjin wound is thirsty, interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold palace, heart failure, cardiogenic shock." Herba Cistanches " nature and flavor are sweet, salty, and temperature is returned kidney, large intestine channel, kidney-replenishing, and benefiting essence-blood moistens just unimpeded.It is the key medicine of treatment sexual impotence." Herba Epimedii " nature and flavor suffering, sweet, temperature is returned liver, kidney channel, and kidney-replenishing is used for impotence and seminal emission, promotes androgen secretion." Rhizoma Curculiginis " nature and flavor suffering, heat is returned the kidney,liver,spleen warp, and kidney-replenishing is used for the sexual impotence cold sperm, the yang deficiency cold diarrhea." Semen Allii Tuberosi " that cooperates temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs again; Warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI antidiarrheal " Fructus Psoraleae "; Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright, antidiarrheal " Semen Cuscutae "; And warming the kidney to invigorate YANG, " Fructus Cnidii " that dampness is dispeled the wind.All medicines are cooperated mutually, thereby reach the effect of reinforcing the kidney and supporting YANG.
Cornu Cervi Pantotrichum described in the present invention, Rhizoma Curculiginis, Herba Cistanches, Semen Allii Tuberosi, Radix Ginseng, Fructus Psoraleae, Radix Angelicae Sinensis, Semen Cuscutae, Fructus Cnidii and Herba Epimedii all are the legal medical materials that record in " Pharmacopoeia of People's Republic of China 2005 version one one ".
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and the consumption of each component all has curative effect preferably in the following weight parts scope:
25～35 parts of 4～7 parts in Cornu Cervi Pantotrichum, 25～35 parts of Rhizoma Curculiginises, 25～35 parts of Herba Cistanches, 25～35 parts of Semen Allii Tuberosi, 16～20 parts of Radix Ginsengs, 25～35 parts of Fructus Psoraleaes, 20～25 parts of Radix Angelicae Sinensis, 25～35 parts of Semen Cuscutae, 20～25 parts of Fructus Cnidiis and Herba Epimedii.
The formula optimization weight portion ratio range of preparation medicine of the present invention is:
28～32 parts of 5～6 parts in Cornu Cervi Pantotrichum, 28～32 parts of Rhizoma Curculiginises, 28～32 parts of Herba Cistanches, 28～32 parts of Semen Allii Tuberosi, 17～19 parts of Radix Ginsengs, 28～32 parts of Fructus Psoraleaes, 22～24 parts of Radix Angelicae Sinensis, 28～32 parts of Semen Cuscutae, 22～24 parts of Fructus Cnidiis and Herba Epimedii.
Optimum weight part proportioning of medicine of the present invention is:
6 parts in Cornu Cervi Pantotrichum, 30 parts of Rhizoma Curculiginises, 30 parts of Herba Cistanches, 30 parts of Semen Allii Tuberosi, 18 parts of Radix Ginsengs, 30 parts of Fructus Psoraleaes, 24 parts of Radix Angelicae Sinensis, 30 parts of Semen Cuscutae, 24 parts of Fructus Cnidiis, 30 parts of Herba Epimedii.
The preparation method of medicine of the present invention: the Pulveratum Cornu Cervi Pantotrichum of described weight proportion is broken into fine powder, with Rhizoma Curculiginis, Herba Cistanches, Semen Allii Tuberosi, Radix Ginseng, Fructus Psoraleae, Radix Angelicae Sinensis, Semen Cuscutae, Fructus Cnidii and Herba Epimedii place container, the water that adds 4～10 times, soak after 1～12 hour, decocted 1～5 hour down at 50 ℃～100 ℃, decoct 1～4 time, filter, merging filtrate, filtrate are evaporated to relative density under 40 ℃～120 ℃ be 1.15～1.40 thick paste, and velvet powder is added in the thick paste, behind the mixing, dry under 60 ℃～120 ℃, pulverize, promptly get the active component of medicine of the present invention.
Can add various conventional adjuvant required when preparing different dosage form in the active component of medicine of the present invention, as filler, absorbent, lubricant, binding agent, disintegrating agent, wetting agent; Method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, powder, tablet, capsule, granule etc.
Below by toxicology and clinical trial data, be described in detail beneficial effect of the present invention.
1, acute toxicity test: with the effective ingredient of medicine of the present invention to the mouse peritoneal administration, median lethal dose(LD 50) (LD50) is 18.07 ± 0.0841g/kg (95% an average credibility), every day, maximum tolerated dose was 31g/kg, was adult every day 500 times of dosage, the no abnormal situation of mice.
2, long term toxicity test: gave rats gavaged (0.93g, 1.86g, 3.72g/kg.BW/ days with effective ingredient of the present invention, 15,30 and 60 times an of daily dose are equivalent to respectively to be grown up), continuous 8 weeks of clothes, the growth promoter of rat, blood system, liver function etc. all there is not tangible accumulate poisoning reaction.The pharmaceutical preparation that this invention is described does not have any toxic and side effects.
3, clinical through system, the relevant clinical data is summarized as follows:
1. pattern of syndrome is marked Huaihe River:
A, decline of the fire from the gate of life type: disease is seen hyposexuality or completely without, dizziness and tinnitus, lusterless complexion, and spirit is withered and is rubbed, coldness of the body with chills, soreness of the waist and knees, lower abdomen is cold painful, clear urine in large amounts, pale tongue with white fur, deep-thready pulse or late.
B, caused by hepatic stagnation qi stagnation: disease is seen the detest sexual life, has no pleasant sensation, and is melancholy joyless, the mind feeling of distension and oppression, and sighing frequently, lower abdominal distention pain, tongue fur is dark red, stringy and thready pulse.
C, deficiency of qi and blood type: disease sees that body is weak, shallow complexion, and dizzy order flower, tired mind, weak breath somnolence is not in the mood for sexual intercourse, lip pale tongue, deficient and thready pulse.
D, phlegm resistance type: disease sees that libido is indifferent, obesity, cardiopalmus, dizziness, and the complexion fubai, limbs are heavy, and even edema, body is tired drowsiness, and pale tongue with white fur is greasy, and moderate pulse is sliding.
2. patient profile: male sexual dysfunction patient 100 examples, minimum 35 years old of age, maximum 72 years old, in the majority with 46 to 65 years old person.
3. usage and dosage: tablet, oral, one time 4,3 times on the one.
4. criterion of therapeutical effect:
A, healing in the recent period: treatment back libido strengthens, the success more than 75% of sexual intercourse chance.
B, produce effects: the medium enhancing of treatment back libido, 50% of sexual intercourse chance can success.
C, effective: treatment back idol has libido or libido on original basis increase being arranged, and erection has improvement, the energy success more than 25% of sexual intercourse chance.
D, invalid: every symptom does not all have improvement before and after the medication.
Disease type and curative effect are as shown in the table.
| Type and curative effect | Cure in the recent period (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| Decline of the fire from the gate of life type 58 examples | 2(3.4％) | 33(56.9％) | 22(37.9％) | 1(1.7％) | 98.2％ |
| Caused by hepatic stagnation qi stagnation 24 examples | 0(0％) | 5(20.8％) | 18(75％) | 1(4.1％) | 95.8％ |
| Deficiency of qi and blood type 12 examples | 1(8.3％) | 5(41.6％) | 3(25％) | 3(25％) | 75％ |
| Phlegm resistance type 6 examples | 1(16.6％) | 1(16.6％) | 2(33.3％) | 2(33.3％) | 66.6％ |
Clinical data confirms that also the course of treatment and curative effect are proportionate and are, libido strengthens or improves total effective rate 93%, erection total effective rate 96%, and sexual intercourse improves always rate 91%.Most of patients obviously obtained effect on 6th.
Above-mentioned toxicity and clinical trial show that the present invention compared with prior art has following outstanding advantage:
(1) wide accommodation: be applicable to the treatment of multiple sexual impotence symptoms such as decline of the fire from the gate of life, stagnation of QI due to depression of the liver, phlegm resistance, deficiency of qi and blood.
(2) safety non-toxic of the present invention has characteristics such as evident in efficacy, short treating period, taking convenience, has better market prospect.
(3) raw material sources of the present invention are abundant, preparation technology is simple, can effectively reduce drug price.
The specific embodiment
Come further to set forth the preparation method of medicine of the present invention by the following examples, but they are not the qualification to content of the present invention.
Embodiment 1
Take by weighing Cornu Cervi Pantotrichum 40g, Rhizoma Curculiginis 250g, Herba Cistanches 250g, Semen Allii Tuberosi 250g, Radix Ginseng 160g, Fructus Psoraleae 250g, Radix Angelicae Sinensis 200g, Semen Cuscutae 250g, Fructus Cnidii 200g, Herba Epimedii 250g are standby.
Earlier Pulveratum Cornu Cervi Pantotrichum is broken into fine powder, standby.Nine flavor medical materials such as Rhizoma Curculiginis are put in the container, added 4 times water, soaked 1 hour, decoct 2 times down at 100 ℃, each 1 hour, filter merging filtrate, filtrate is evaporated to relative density under 40 ℃ be 1.15 thick paste, velvet powder is added in the thick paste, behind the mixing, dry down at 60 ℃, pulverize, powder gets dry extract.
Embodiment 2
Repeat embodiment 1, following difference is arranged: it is standby to take by weighing Cornu Cervi Pantotrichum 60g, Rhizoma Curculiginis 300g, Herba Cistanches 300g, Semen Allii Tuberosi 300g part, Radix Ginseng 180g, Fructus Psoraleae 300g, Radix Angelicae Sinensis 240g, Semen Cuscutae 300g, Fructus Cnidii 240g and Herba Epimedii 300g.
Embodiment 3
Repeat embodiment 1, following difference is arranged: it is standby to take by weighing Cornu Cervi Pantotrichum 70g, Rhizoma Curculiginis 350g, Herba Cistanches 350g, Semen Allii Tuberosi 350g part, Radix Ginseng 200g, Fructus Psoraleae 350g, Radix Angelicae Sinensis 250g, Semen Cuscutae 350g, Fructus Cnidii 250g and Herba Epimedii 350g.
Embodiment 4
Repeat embodiment 1, following difference is arranged: add 10 times water, soaked 12 hours, decoct 4 times down at 50 ℃, each 5 hours, filter merging filtrate, filtrate is evaporated to relative density under 120 ℃ be 1.40 thick paste, velvet powder is added in the thick paste, behind the mixing, dry down at 120 ℃, pulverize, get the active component of medicine of the present invention.
Embodiment 5
Get the active component of embodiment 2 gained medicines, add 9 parts of microcrystalline Cellulose, 0.9 part of sodium lauryl sulphate, 3 parts of Pulvis Talci, behind the mixing, use the 40-80% alcohol granulation, drying adds 1.5 parts of magnesium stearate, mixing, and tabletting is made tablet.
Embodiment 6
Get the active component of embodiment 2 gained medicines, add 8 parts of microcrystalline Cellulose, 0.8 part of sodium lauryl sulphate, 2 parts of Pulvis Talci, behind the mixing,, add 1 part of magnesium stearate with 40～80% alcohol granulations, drying, mixing, filled capsules is made capsule.
Embodiment 7
Get the active component of embodiment 2 gained medicines, add 90 parts of cane sugar powders, mixing is granulated, drying, and granulate is made granule.
Claims (5)
1. medicine for the treatment of sexual impotence, the primary raw material medicine that it is characterized in that making this medicine active ingredient are formed: 25～35 parts of 4～7 parts in Cornu Cervi Pantotrichum, 25～35 parts of Rhizoma Curculiginises, 25～35 parts of Herba Cistanches, 25～35 parts of Semen Allii Tuberosi, 20～25 parts of Radix Angelicae Sinensis, 16～20 parts of Radix Ginsengs, 25～35 parts of Fructus Psoraleaes, 25～35 parts of Semen Cuscutae, 20～25 parts of Fructus Cnidiis and Herba Epimedii.
2. medicine according to claim 1, wherein the consumption of each crude drug is: 28～32 parts of 5～6 parts in Cornu Cervi Pantotrichum, 28～32 parts of Rhizoma Curculiginises, 28～32 parts of Herba Cistanches, 28～32 parts of Semen Allii Tuberosi, 17～19 parts of Radix Ginsengs, 28～32 parts of Fructus Psoraleaes, 22～24 parts of Radix Angelicae Sinensis, 28～32 parts of Semen Cuscutae, 22～24 parts of Fructus Cnidiis and Herba Epimedii.
3. medicine according to claim 1, wherein the consumption of each crude drug is: 30 parts of 6 parts in Cornu Cervi Pantotrichum, 30 parts of Rhizoma Curculiginises, 30 parts of Herba Cistanches, 30 parts of Semen Allii Tuberosi, 18 parts of Radix Ginsengs, 30 parts of Fructus Psoraleaes, 24 parts of Radix Angelicae Sinensis, 30 parts of Semen Cuscutae, 24 parts of Fructus Cnidiis and Herba Epimedii.
4. the preparation method of the described medicine of claim 1 is characterized in that: the Pulveratum Cornu Cervi Pantotrichum with described weight proportion is broken into fine powder earlier; Rhizoma Curculiginis, Herba Cistanches, Semen Allii Tuberosi, Radix Ginseng, Fructus Psoraleae, Radix Angelicae Sinensis, Semen Cuscutae, Fructus Cnidii and Herba Epimedii are placed container, add 4～10 times water, soak after 1～12 hour, decocted 1～5 hour down at 50 ℃～100 ℃, decoct 1～4 time, filter merging filtrate; Filtrate is evaporated to relative density under 40 ℃～120 ℃ be 1.15～1.40 thick paste, velvet powder is added in the thick paste, behind the mixing, 60 ℃～120 ℃ dry down, pulverize, promptly get required active component.
5. according to the preparation method of the described medicine of claim 4, it is characterized in that: required conventional adjuvant when adding the preparation different dosage form in the active component of described medicine respectively is prepared into pill, powder, tablet, capsule or granule with the method for Chinese medicinal of routine.
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| CNA2006100108312A CN1876066A (en) | 2006-04-19 | 2006-04-19 | A medicine for treating impotence and preparation method thereof |
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| CNA2006100108312A CN1876066A (en) | 2006-04-19 | 2006-04-19 | A medicine for treating impotence and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028475B (en) * | 2007-04-16 | 2010-05-19 | 北京艺信堂医药研究所 | Chinese-medicinal preparation for treating asynodia |
| CN104232437A (en) * | 2014-08-26 | 2014-12-24 | 舒欣 | Yang-tonifying medicinal wine and making method thereof |
| CN104644982A (en) * | 2013-11-20 | 2015-05-27 | 张建康 | Drug composition for treating insomnia and kidney deficiency |
| CN105079500A (en) * | 2015-09-21 | 2015-11-25 | 南京正亮医药科技有限公司 | Traditional Chinese medicinal ointment for treating erectile dysfunction |
| CN105362877A (en) * | 2015-10-17 | 2016-03-02 | 薛学明 | Medicine for prolonging coitus time and preparation method thereof |
| CN110403973A (en) * | 2019-08-12 | 2019-11-05 | 徐洪林 | A kind of member oral medicinal herb medicament and emplastrum admittedly |
-
2006
- 2006-04-19 CN CNA2006100108312A patent/CN1876066A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028475B (en) * | 2007-04-16 | 2010-05-19 | 北京艺信堂医药研究所 | Chinese-medicinal preparation for treating asynodia |
| CN104644982A (en) * | 2013-11-20 | 2015-05-27 | 张建康 | Drug composition for treating insomnia and kidney deficiency |
| CN104232437A (en) * | 2014-08-26 | 2014-12-24 | 舒欣 | Yang-tonifying medicinal wine and making method thereof |
| CN105079500A (en) * | 2015-09-21 | 2015-11-25 | 南京正亮医药科技有限公司 | Traditional Chinese medicinal ointment for treating erectile dysfunction |
| CN105362877A (en) * | 2015-10-17 | 2016-03-02 | 薛学明 | Medicine for prolonging coitus time and preparation method thereof |
| CN110403973A (en) * | 2019-08-12 | 2019-11-05 | 徐洪林 | A kind of member oral medicinal herb medicament and emplastrum admittedly |
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