CN106109592A - A kind of preparation method of Flos Lonicerae cold granules - Google Patents
A kind of preparation method of Flos Lonicerae cold granules Download PDFInfo
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- CN106109592A CN106109592A CN201610577966.0A CN201610577966A CN106109592A CN 106109592 A CN106109592 A CN 106109592A CN 201610577966 A CN201610577966 A CN 201610577966A CN 106109592 A CN106109592 A CN 106109592A
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- 241000628997 Flos Species 0.000 title claims abstract description 49
- 239000008187 granular material Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000007921 spray Substances 0.000 claims abstract description 32
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000005469 granulation Methods 0.000 claims abstract description 18
- 230000003179 granulation Effects 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 16
- 238000001914 filtration Methods 0.000 claims abstract description 14
- 238000009835 boiling Methods 0.000 claims abstract description 8
- 238000001816 cooling Methods 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 2
- 229940010454 licorice Drugs 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 9
- 239000000470 constituent Substances 0.000 abstract description 5
- 239000002245 particle Substances 0.000 abstract description 4
- 239000000047 product Substances 0.000 description 10
- 230000000857 drug effect Effects 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- 238000002844 melting Methods 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 4
- 239000003595 mist Substances 0.000 description 4
- 238000004064 recycling Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 241000202807 Glycyrrhiza Species 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides the preparation method of a kind of Flos Lonicerae cold granules, step includes: weigh Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Radix Platycodonis, Radix Glycyrrhizae, boiling, take decocting liquid filtering and concentrating, add ethanol isopyknic with concentrated solution, filter after standing, it is concentrated into the thick paste that relative density is 1.20, Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Radix Platycodonis, the Icing Sugar of Radix Glycyrrhizae gross mass 54% 56% is added after cooling, spray granulation, the process conditions of described spray granulation are: spray rate 58 62g/min, atomizing pressure 2.0 2.5kg, and temperature of charge is 78 82 DEG C.The preparation method technique of this Flos Lonicerae cold granules is the most controlled, and productivity is high, and the medicine effect prepared is good, and active constituents of medicine loss is few, and particle shape is preferable.
Description
Technical field
The present invention relates to common cold treatment technical field, particularly to the preparation method of a kind of Flos Lonicerae cold granules, the party
Flos Lonicerae cold granules good drug efficacy prepared by method, active constituents of medicine loss is few.
Background technology
The Chinese medicine preparation that Flos Lonicerae cold granules is made up of medical materials such as Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Radix Platycodonis, Radix Glycyrrhizaes, has
Heat clearing away, induce sweat, effect of sore-throat relieving, can be used for cold, fever, headache, laryngopharynx swelling and pain, effectively treat anemopyretic cold.
Existing Flos Lonicerae cold granules is due to prescription and technological reason, and curative effect is not satisfactory, there is medicine in preparation process
Thing active ingredient loss is big waits deficiency.The many sugar contents of Flos Lonicerae cold granules of Clinical practice are high at present, core in manufacturing process
Medicine heated time is long, affects the quality of medicine, and the whole processing technology time is long, complex procedures, the particle shape prepared
Undesirable.The preparation method of existing Flos Lonicerae cold granules is difficult to meet the market demand.
Summary of the invention
In view of this, the invention provides the preparation method of a kind of Flos Lonicerae cold granules, this Flos Lonicerae cold granules
Preparation method technique is the most controlled, and productivity is high, and the medicine effect prepared is good, and active constituents of medicine loss is few, granulated
State is preferable.
The invention provides the preparation method of a kind of Flos Lonicerae cold granules, step includes: weighs Flos Lonicerae, Fructus Forsythiae, prevent
Wind, Radix Platycodonis, Radix Glycyrrhizae, boiling, take decocting liquid filtering and concentrating, add ethanol isopyknic with concentrated solution, filter after standing, dense
It is reduced to the thick paste that relative density is 1.20, after cooling, adds Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Radix Platycodonis, Radix Glycyrrhizae gross mass 54%-56%
Icing Sugar, spray granulation, the process conditions of described spray granulation are: spray rate 58-62g/min, atomizing pressure 2.0-
2.5kg, temperature of charge is 78-82 DEG C.
The invention has the beneficial effects as follows: after each medical material is concentrated the thick paste for certain density by the present invention, according to character of medicinal material
Spray granulation is carried out, it is to avoid medicine heated time is long and affects pharmaceutically active and drug effect under specific condition, and obtain
Medicine effect is good, and active constituents of medicine loss is few, and particle shape is preferable, and mobility and melting are good, and character is homogeneous, the method work
Sequence is simple, time-consumingly reduces, and productivity improves, beneficially quality control.
Detailed description of the invention
The invention provides the preparation method of a kind of Flos Lonicerae cold granules, step includes: weighs Flos Lonicerae, Fructus Forsythiae, prevent
Wind, Radix Platycodonis, Radix Glycyrrhizae, boiling, take decocting liquid filtering and concentrating, add ethanol isopyknic with concentrated solution, filter after standing, dense
It is reduced to the thick paste that relative density is 1.20, after cooling, adds Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Radix Platycodonis, Radix Glycyrrhizae gross mass 54%-56%
Icing Sugar, spray granulation, the process conditions of described spray granulation are: spray rate 58-62g/min, atomizing pressure 2.0-
2.5kg, temperature of charge is 78-82 DEG C.
Under specific condition, carry out spray granulation according to character of medicinal material, make dry materials substantially shortening full and uniform, time-consuming,
Thus reduce medicine heated time, at utmost maintain pharmaceutically active and drug effect, reduce the loss of active constituents of medicine.Reduce
The addition of Icing Sugar, it is ensured that reducing sugar part while mouthfeel and take in more healthy, the minimizing of sugar content is in spray granulation mistake simultaneously
In journey, granule is pushed the speed and is increased, and improves preparation efficiency.By the condition of specific spray granulation, proper extension drop
The surface evaporation time, reduce drop rate of rise in temperature and make drop centered water content reduce, prevent granule rapid expansion from rupturing, increase
Bulky grain particle diameter so as to get the homogeneous ideal of grain shape, mobility, melting are good, and avoid in pelletization solvent residual
Cause complexion changed.Technique time-consumingly reduces, and product yield improves.
Preferably, described decoction is to decoct 2 times, when decocting for the first time at 95-100 DEG C of the water using 7-9 times of quality of medicinal material
Between 3 hours, decocting time 2 hours for the second time.Decoct under the conditions of Gai, make effective ingredient dissolution more abundant, improve
The drug effect of product and productivity.
Preferably, the process conditions of described spray granulation are: spray rate 60g/min, atomizing pressure 2.1kg, material temperature
Spend 80 DEG C.
More preferably, the twice that quality is Radix Glycyrrhizae of described Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Radix Platycodonis.
Preferably, decocting liquid filtering and concentrating is taken described in for being concentrated into Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Radix Platycodonis, licorice raw material gross mass
It is 0.91-1.0 with the mass volume ratio of concentrated solution.
The preparation method of the Flos Lonicerae cold granules provided the present invention below in conjunction with specific embodiment gives further
Explanation.The embodiments described below is exemplary, is only used for explaining the present invention, and is not considered as limiting the invention.
Experimental technique in following embodiment, if no special instructions, is conventional method.Reality used in following embodiment
Test material if no special instructions, be market and be commercially available.
Embodiment 1
Present embodiments providing the preparation method of a kind of Flos Lonicerae cold granules, step includes:
Weigh Flos Lonicerae 345.6g, Fructus Forsythiae 345.6g, Radix Saposhnikoviae 345.6g, Radix Platycodonis 345.6g, Radix Glycyrrhizae 172.8g, add decocting
Boiling, described decoction is to decoct 2 times at 100 DEG C of the water using 8 times of quality of medicinal materials, and decocting time 3 hours for the first time, second time decocts
Time 2 h.Collecting decoction filtering and concentrating, to 1700ml, adds ethanol isopyknic with concentrated solution, stirs evenly, and stands 12 hours
Rear filtration, filtrate recycling ethanol, it is concentrated into the thick paste that relative density is 1.20 (60 DEG C), after cooling, adds the Icing Sugar of 845g, spray
Mist is pelletized, and the process conditions of described spray granulation are: spray rate 60g/min, atomizing pressure 2.1kg, and temperature of charge is 80 DEG C,
Make 1000g, obtain product Flos Lonicerae cold granules.
Flos Lonicerae cold granules prepared by the present embodiment, the homogeneous ideal of grain shape, mobility, melting are good, maximum journey
Degree maintains pharmaceutically active and drug effect, good effect, stores 24 months under normal temperature condition, and indices all meets constitutional law calibration
Standard, illustrates that product stability is good, and preparation technology is the most controlled, time-consumingly few, productivity is high.
Embodiment 2
Present embodiments providing the preparation method of a kind of Flos Lonicerae cold granules, step includes:
Weigh Flos Lonicerae 345.6g, Fructus Forsythiae 345.6g, Radix Saposhnikoviae 345.6g, Radix Platycodonis 345.6g, Radix Glycyrrhizae 172.8g, add decocting
Boiling, described decoction is to decoct 2 times at 95 DEG C of the water using 7 times of quality of medicinal materials, and decocting time 3 hours for the first time, second time decocts
Time 2 h.Collecting decoction filtering and concentrating, to 1555ml, adds ethanol isopyknic with concentrated solution, stirs evenly, and stands 12 hours
Rear filtration, filtrate recycling ethanol, it is concentrated into the thick paste that relative density is 1.20 (60 DEG C), after cooling, adds the Icing Sugar of 850g, spray
Mist is pelletized, and the process conditions of described spray granulation are: spray rate 62g/min, atomizing pressure 2.5kg, and temperature of charge is 82 DEG C,
Make 1000g, obtain product Flos Lonicerae cold granules.
Flos Lonicerae cold granules prepared by the present embodiment, the homogeneous ideal of grain shape, mobility, melting are good, maximum journey
Degree maintains pharmaceutically active and drug effect, good effect, stores 24 months under normal temperature condition, and indices all meets constitutional law calibration
Standard, illustrates that product stability is good, and preparation technology is the most controlled, time-consumingly few, productivity is high.
Embodiment 3
Present embodiments providing the preparation method of a kind of Flos Lonicerae cold granules, step includes:
Weigh Flos Lonicerae 345.6g, Fructus Forsythiae 345.6g, Radix Saposhnikoviae 345.6g, Radix Platycodonis 345.6g, Radix Glycyrrhizae 172.8g, add decocting
Boiling, described decoction is to decoct 2 times at 98 DEG C of the water using 9 times of quality of medicinal materials, and decocting time 3 hours for the first time, second time decocts
Time 2 h.Collecting decoction filtering and concentrating, to 1600ml, adds ethanol isopyknic with concentrated solution, stirs evenly, and stands 12 hours
Rear filtration, filtrate recycling ethanol, it is concentrated into the thick paste that relative density is 1.20 (60 DEG C), after cooling, adds the Icing Sugar of 870g, spray
Mist is pelletized, and the process conditions of described spray granulation are: spray rate 58g/min, atomizing pressure 2.3kg, and temperature of charge is 78 DEG C,
Make 1000g, obtain product Flos Lonicerae cold granules.
Flos Lonicerae cold granules prepared by the present embodiment, the homogeneous ideal of grain shape, mobility, melting are good, maximum journey
Degree maintains pharmaceutically active and drug effect, good effect, stores 24 months under normal temperature condition, and indices all meets constitutional law calibration
Standard, illustrates that product stability is good, and preparation technology is the most controlled, time-consumingly few, productivity is high.
Embodiment 4
Present embodiments providing the preparation method of a kind of Flos Lonicerae cold granules, step includes:
Weigh Flos Lonicerae 345.6g, Fructus Forsythiae 345.6g, Radix Saposhnikoviae 345.6g, Radix Platycodonis 345.6g, Radix Glycyrrhizae 172.8g, add decocting
Boiling, described decoction is to decoct 2 times at 97 DEG C of the water using 8 times of quality of medicinal materials, and decocting time 3 hours for the first time, second time decocts
Time 2 h.Collecting decoction filtering and concentrating, to 1650ml, adds ethanol isopyknic with concentrated solution, stirs evenly, and stands 12 hours
Rear filtration, filtrate recycling ethanol, it is concentrated into the thick paste that relative density is 1.20 (60 DEG C), after cooling, adds the Icing Sugar of 860g, spray
Mist is pelletized, and the process conditions of described spray granulation are: spray rate 60g/min, atomizing pressure 2.1kg, and temperature of charge is 80 DEG C,
Make 1000g, obtain product Flos Lonicerae cold granules.
Flos Lonicerae cold granules prepared by the present embodiment, the homogeneous ideal of grain shape, mobility, melting are good, maximum journey
Degree maintains pharmaceutically active and drug effect, good effect, stores 24 months under normal temperature condition, and indices all meets constitutional law calibration
Standard, illustrates that product stability is good, and preparation technology is the most controlled, time-consumingly few, productivity is high.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and
Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (5)
1. the preparation method of a Flos Lonicerae cold granules, it is characterised in that: step includes: weigh Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae,
Radix Platycodonis, Radix Glycyrrhizae, boiling, take decocting liquid filtering and concentrating, add ethanol isopyknic with concentrated solution, filter after standing, concentrate
It is the thick paste of 1.20 to relative density, after cooling, adds Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Radix Platycodonis, Radix Glycyrrhizae gross mass 54%-56%
Icing Sugar, spray granulation, the process conditions of described spray granulation are: spray rate 58-62g/min, atomizing pressure 2.0-2.5kg,
Temperature of charge is 78-82 DEG C.
2. the preparation method of Flos Lonicerae cold granules as claimed in claim 1, it is characterised in that: described decoction is for using 7-9
Decoct 2 times at 95-100 DEG C of the water of times quality of medicinal material, decocting time 3 hours for the first time, for the second time decocting time 2 hours.
3. the preparation method of Flos Lonicerae cold granules as claimed in claim 1, it is characterised in that: the technique of described spray granulation
Condition is: spray rate 60g/min, atomizing pressure 2.1kg, temperature of charge 80 DEG C.
4. the preparation method of Flos Lonicerae cold granules as claimed in claim 3, it is characterised in that: described Flos Lonicerae, Fructus Forsythiae, anti-
Wind, the quality of Radix Platycodonis are the twice of Radix Glycyrrhizae.
5. the preparation method of Flos Lonicerae cold granules as claimed in claim 1, it is characterised in that take decocting liquid filtering and concentrating described in:
It is 0.91-1.0 for being concentrated into Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Radix Platycodonis, licorice raw material gross mass with the mass volume ratio of concentrated solution.
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| CN1368261A (en) * | 2001-02-06 | 2002-09-11 | 杨孟君 | Nano medicine 'Xiaoyanjiedu' and its preparing process |
| CN101433595A (en) * | 2008-12-10 | 2009-05-20 | 河南大学 | Desertliving cistanche alcohol extract as well as preparation method and use thereof |
| CN101658646A (en) * | 2009-04-28 | 2010-03-03 | 辽宁本溪三药有限公司 | Pharmaceutical composition for curing summer-heat cold and preparation method thereof |
| CN101632747A (en) * | 2009-08-28 | 2010-01-27 | 南京中山制药有限公司 | Preparation technology of children cold relaxation grain |
| CN102657721A (en) * | 2012-04-16 | 2012-09-12 | 杭州天诚药业有限公司 | Cold granule and preparation method thereof |
| CN103055062A (en) * | 2013-01-08 | 2013-04-24 | 栾川本草生物开发有限公司 | Granule infusion for heat clearing and dampness dispelling, and its preparation method |
| CN103919860A (en) * | 2014-04-14 | 2014-07-16 | 海南葫芦娃制药有限公司 | Honeysuckle cold curing granule and preparation method thereof |
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