CN113384650A

CN113384650A - Preparation method of infantile lung-heat cough and asthma granules

Info

Publication number: CN113384650A
Application number: CN202110661152.6A
Authority: CN
Inventors: 刘景萍; 刘全国; 陈克领; 林海银; 吴育强
Original assignee: Hainan Huluwa Pharmaceutical Group Co ltd
Current assignee: Hainan Huluwa Pharmaceutical Group Co ltd
Priority date: 2021-06-15
Filing date: 2021-06-15
Publication date: 2021-09-14
Anticipated expiration: 2041-06-15
Also published as: CN113384650B

Abstract

The invention provides a preparation method of particles for treating cough and asthma caused by lung heat of children, which comprises the following steps: (1) soaking Glycyrrhrizae radix, flos Lonicerae, semen Armeniacae amarum, and rhizoma anemarrhenae in hot water, adding pulverized Gypsum Fibrosum, radix Isatidis, radix Ophiopogonis, and herba Houttuyniae during decocting, and filtering to obtain filtrate 1; (2) pulverizing herba Ephedrae, fructus forsythiae, and Scutellariae radix, soaking in hot water, decocting repeatedly, and filtering to obtain filtrate 2; (3) concentrating the filtrate 1 and filtrate 2 under reduced pressure to obtain fluid extract 1 and fluid extract 2, and refrigerating the fluid extract 1 with mannitol for a long time; (4) mixing the fluid extract 1 and fluid extract 2, preheating with hot air, spray drying, adding sodium cyclamate powder, and hot air drying. The granules for treating infantile lung-heat cough and asthma prepared by the invention are fresh and sweet in taste, good in stability, high in content of effective components and good in curative effect.

Description

Preparation method of infantile lung-heat cough and asthma granules

Technical Field

The invention relates to the field of preparation of medicinal preparations, in particular to a preparation method of particles for treating infantile lung heat cough and asthma.

Background

The infantile lung-heat cough and asthma particle is a compound preparation of eleven traditional Chinese medicines, has the functions of clearing heat and detoxicating, freeing lung and relieving cough, and reducing phlegm and asthma, and is mainly used for cold, bronchitis, asthmatic bronchitis and bronchopneumonia caused by phlegm-heat obstructing lung. In order to improve sweetness of taste, make children more easily accept and increase compliance of clinical use of children, a process of adding auxiliary materials is usually adopted to prepare a sugar-type specification medicament. In general, sucrose, which is selected as an adjuvant, is widely used in oral preparations because it can be used not only as a filler but also as a sweetener. However, sucrose tends to absorb moisture and become damp, and the addition of an excessive amount of sugar is not favorable for the growth of children. The traditional Chinese medicine extract has high viscosity, and the prepared finished product has unstable quality and low curative effect when being mixed with auxiliary materials, and the solution stability is not high. For example, application No. CN108553578A discloses a preparation method of a 4 g granule for treating infantile cough and asthma due to lung heat, which can improve the cough and asthma relieving effect of the product; application number CN101780214A discloses a method for preparing infantile lung heat cough and asthma granules, which enables baicalin identification items in the product to be qualified and improves the product qualification rate. But only respectively improves the stability of the ephedra content and the baicalin content, and does not relate to the research on the granular mouthfeel.

Disclosure of Invention

Therefore, the invention aims to provide the preparation method of the infantile lung heat cough and asthma particle, so that the prepared particle has fresh and sweet taste, good stability, high content of effective components and good curative effect.

The technical scheme of the invention is realized as follows:

a preparation method of a particle for treating cough and asthma caused by lung heat of children comprises the following steps:

s1, mixing the raw materials in a mass ratio of 24: 10: 10: 10 weighing gypsum, radix isatidis, radix ophiopogonis and herba houttuyniae respectively, crushing, and sieving by 60-80 meshes to obtain mixed crushed materials;

s2 is prepared from the following raw materials in percentage by mass: 10: 6: weighing liquorice, honeysuckle, bitter apricot kernels and rhizoma anemarrhenae, adding the liquorice, the honeysuckle, the bitter apricot kernels and the rhizoma anemarrhenae into water with the temperature of 50-60 ℃, and soaking for 2-4 hours, wherein the weight ratio of the material liquid to the material liquid is 1: 4 ~ 6, heat to 80 ~ 90 ℃ and carry out the first time and boil out 1 ~ 3h, the mixed crushing thing and 80 ~ 90 ℃ water of step S1 are added to the boiling process, and the stirring, the weight ratio of mixed crushing thing and water is 1: 3-5, standing for 2-4 h after the boiling is finished, heating to 90-95 ℃ for second boiling for 2-4 h, cooling, and filtering to obtain a filtrate 1;

s3 is prepared from the following raw materials in percentage by mass: 10: 10, weighing and crushing the ephedra, the forsythia and the scutellaria baicalensis, adding the crushed ephedra, the forsythia and the scutellaria baicalensis into water with the temperature of 60-80 ℃, and soaking for 2-4 h, wherein the weight ratio of feed liquid is 1: 6-8, heating to 90-95 ℃, decocting for 4-6 h, filtering, adding water, decocting repeatedly for 2-3 times, and combining filtrates to obtain a filtrate 2;

s4, respectively carrying out reduced pressure concentration on the filtrate 1 and the filtrate 2 under the concentration conditions that the temperature is 65-75 ℃, the pressure is-0.02-0.04 MPa, and the concentration is carried out until the relative density is about 1.10-1.21, thus obtaining a clear paste 1 and a clear paste 2, adding mannitol into the clear paste 1, uniformly mixing, refrigerating at 10-20 ℃ for 30-40 min, and standing the clear paste 2 at normal temperature for 30-40 min;

s5 mixing the fluid extract 1 and the fluid extract 2, stirring for 10-15 min, preheating with hot air at 25-35 ℃, and spray drying under the conditions of 60-70 ℃, spraying speed of 1-2L of fluid extract/min, air inlet temperature of 140-160 ℃, and air flow rate of 4000-5000 m³The air outlet temperature is 80-90 ℃ to obtain clear paste powder, sodium cyclamate powder is added, and granules are obtained after uniform mixing and granulation; the weight parts of the clear paste 1, the clear paste 2, the mannitol and the sodium cyclamate powder are 18-24 parts of clear paste 1, 4-10 parts of clear paste 2, 1.5-2.0 parts of mannitol and 1.2-1.7 parts of sodium cyclamate powder;

s6, drying the obtained particles with hot air at the temperature of 70-90 ℃ for 50-70 min, and mixing uniformly to obtain the finished product.

Compared with the prior art, the invention has the beneficial effects that: (1) according to the invention, the auxiliary materials are mannitol and sodium cyclamate for sweet taste adjustment, and mannitol and the clear paste 1 are mixed and combined for long-time refrigeration treatment, so that the clear paste is promoted to be solidified, mannitol molecules can be uniformly distributed in the clear paste, the taste of the prepared particles is sweet, the moisture in the clear paste can be stably adjusted, the defect of non-uniformity of clear paste powder granulation particles can be overcome, and the particles can be more uniformly and stably formed;

(2) when the traditional Chinese medicine is extracted, hot water is added and then heated, so that the heat movement is accelerated in the process that the temperature of water molecules in the hot water is rapidly increased, the heat circulation of the solution is promoted, and the release of traditional Chinese medicine components is facilitated; adding the pulverized materials of gypsum, radix isatidis, radix ophiopogonis and herba houttuyniae in the process of decocting the liquorice, the honeysuckle, the bitter almond and the rhizoma anemarrhenae, continuously decocting to enable the eight traditional Chinese medicine components to interact, pulverizing the ephedra, the fructus forsythiae and the scutellaria baicalensis, and separately decocting to be beneficial to improving the content of effective components; the invention divides the traditional Chinese medicines into parts, adopts the modes of hot water soaking, temperature rising and boiling to carry out water extraction, further improves the effective components, accelerates the recovery time of disease healing, and has stable product quality;

(3) the invention adopts the respective preparation of the clear paste, the preheating is carried out before the spray drying, the viscosity of the clear paste is reduced, the mixing with auxiliary materials is easy, the stability of the product quality is improved, simultaneously, the prepared granules have good fluidity and high stability, the detection of the contents of ephedrine, phillyrin and baicalin is not influenced, and the product meets the quality standard.

Detailed Description

In order to better understand the technical content of the invention, specific examples are provided below to further illustrate the invention.

The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.

The materials, reagents and the like used in the examples of the present invention can be obtained commercially without specific description.

Example 1

A preparation method of a particle for treating infantile lung heat cough and asthma comprises the following traditional Chinese medicinal materials by weight:

s1, mixing the raw materials in a mass ratio of 24: 10: 10: weighing 2400g of gypsum, 1000g of radix isatidis, 1000g of radix ophiopogonis and 1000g of herba houttuyniae, crushing, and sieving by a 70-mesh sieve to obtain a mixed crushed substance;

s2 is prepared from the following raw materials in percentage by mass: 10: 6: 10, weighing 300g of liquorice, 1000g of honeysuckle, 600g of bitter apricot seed and 1000g of rhizoma anemarrhenae, adding 11600g of 50 ℃ water, soaking for 2h, heating to 80 ℃ for first decoction for 1h, adding 16200g of the mixed crushed material obtained in the step S1 and 80 ℃ water in the decoction process, uniformly stirring, standing for 2h after the decoction is completed, heating to 90 ℃ for second decoction for 2h, cooling, and filtering to obtain a filtrate 1;

s3 is prepared from the following raw materials in percentage by mass: 10: 10, weighing 300g of ephedra, 1000g of forsythia and 1000g of scutellaria baicalensis, crushing, adding 13800g of water at 60 ℃, standing for 2h, heating to 90 ℃, decocting for 4h, filtering, adding water, repeatedly decocting for 2 times, and combining the filtrates to obtain a filtrate 2;

s4 concentrating filtrate 1 and filtrate 2 under reduced pressure respectively at 65 deg.C and 0.04MPa until the relative density is about 1.21 to obtain fluid extract 1 and fluid extract 2, weighing 2700g fluid extract 1, adding 225g mannitol, mixing, refrigerating at 10 deg.C for 30min, weighing 600g fluid extract 2, and standing at room temperature for 30 min;

s5 mixing 2700g of fluid extract 1 and 225g of fluid extract 2, stirring for 12min, preheating with hot air at 25 deg.C, spray drying at 60 deg.C, spraying speed of 1L of fluid extract/min, air inlet temperature of 140 deg.C, and air flow rate of 4000m³The air outlet temperature is 80 ℃ to obtain clear paste powder, 180g of sodium cyclamate powder is added, and granules are obtained after uniform mixing and granulation;

s6 hot air drying the obtained particles at 70 deg.C for 50min, and mixing to obtain the final product.

Example 2

s2 is prepared from the following raw materials in percentage by mass: 10: 6: 10, weighing 300g of liquorice, 1000g of honeysuckle, 600g of bitter apricot seeds and 1000g of rhizoma anemarrhenae, adding 17400g of water at 60 ℃, soaking for 4h, heating to 90 ℃, decocting for 2h for the first time, adding 27000g of the mixed crushed material obtained in the step S1 and the water at 90 ℃ in the decocting process, stirring uniformly, standing for 4h after the decocting is finished, heating to 95 ℃, decocting for 4h for the second time, cooling, and filtering to obtain a filtrate 1;

s3 is prepared from the following raw materials in percentage by mass: 10: 10, weighing 300g of ephedra, 1000g of forsythia and 1000g of scutellaria baicalensis, crushing, adding 18400g of water with the temperature of 80 ℃, standing for 4h, heating to 95 ℃, decocting for 6h, filtering, adding water, repeatedly decocting for 2 times, and combining the filtrates to obtain a filtrate 2;

s4 respectively concentrating the filtrate 1 and the filtrate 2 under reduced pressure at 65-75 deg.C under-0.02-0.04 MPa to obtain fluid extract 1 and fluid extract 2, weighing 3600g of fluid extract 1, adding 300g of mannitol, mixing, refrigerating at 20 deg.C for 40min, weighing 1500g of fluid extract 2, and standing at room temperature for 40 min;

s5 mixing fluid extract 1 (3600 g) and fluid extract 2 (1500 g), stirring for 12min, preheating with hot air at 35 deg.C, spray drying at 70 deg.C and spray speed of 1L/min, air intake temperature of 160 deg.C and air flow rate of 5000m³The air outlet temperature is 90 ℃ to obtain clear paste powder, 255g of sodium cyclamate powder is added, and granules are obtained after uniform mixing and granulation;

s6 hot air drying the obtained granules at 90 deg.C for 70min, and mixing to obtain the final product.

Example 3

s2 is prepared from the following raw materials in percentage by mass: 10: 6: 10, weighing 300g of liquorice, 1000g of honeysuckle, 600g of bitter apricot seeds and 1000g of rhizoma anemarrhenae, adding 14500g of 55 ℃ water, soaking for 4h, heating to 80 ℃ for first decoction for 3h, adding 21600g of the mixed crushed material obtained in the step S1 and 85 ℃ water in the decoction process, uniformly stirring, standing for 3h after the decoction is finished, heating to 90 ℃ for second decoction for 3h, cooling, and filtering to obtain a filtrate 1;

s3 is prepared from the following raw materials in percentage by mass: 10: 10, weighing 300g of ephedra, 1000g of forsythia and 1000g of scutellaria baicalensis, crushing, adding 18400g of water with the temperature of 80 ℃, standing for 3h, heating to 92 ℃, decocting for 6h, filtering, adding water, repeatedly decocting for 3 times, and combining the filtrates to obtain a filtrate 2;

s4 concentrating filtrate 1 and filtrate 2 under reduced pressure respectively at 75 deg.C under 0.02MPa until the relative density is about 1.10 to obtain fluid extract 1 and fluid extract 2, weighing 3300g of fluid extract 1, adding 255g of mannitol, mixing, refrigerating at 20 deg.C for 35min, weighing 1050g of fluid extract 2, and standing at normal temperature for 35 min;

s5 mixing 3300g of fluid extract 1 and 1050g of fluid extract 2, stirring for 12min, preheating with hot air at 35 deg.C, spray drying at 70 deg.C and spray speed of 1L/min, air inlet temperature of 160 deg.C and air flow rate of 5000m³The air outlet temperature is 90 ℃ to obtain clear paste powder, 210g of sodium cyclamate powder is added, and granules are obtained after uniform mixing and granulation;

Example 4

s1, mixing the raw materials in a mass ratio of 24: 10: 10: weighing 2400g of gypsum, 1000g of radix isatidis, 1000g of radix ophiopogonis and 1000g of herba houttuyniae, crushing, and sieving by a 60-80-mesh sieve to obtain a mixed crushed substance;

s2 is prepared from the following raw materials in percentage by mass: 10: 6: 10, weighing 300g of liquorice, 1000g of honeysuckle, 600g of bitter apricot seeds and 1000g of rhizoma anemarrhenae, adding 14500g of 55 ℃ water, soaking for 3h, heating to 85 ℃ for first decoction for 2.5h, adding 21600g of the mixed crushed material obtained in the step S1 and 85 ℃ water in the decoction process, uniformly stirring, standing for 3h after the decoction is finished, heating to 95 ℃ for second decoction for 3.5h, cooling, and filtering to obtain a filtrate 1;

s3 is prepared from the following raw materials in percentage by mass: 10: 10, weighing 300g of ephedra, 1000g of forsythia and 1000g of scutellaria baicalensis, crushing, adding 18400g of water with the temperature of 70 ℃, standing for 3h, heating to 92 ℃, decocting for 6h, filtering, adding water, repeatedly decocting for 3 times, and combining the filtrates to obtain a filtrate 2;

s4 concentrating filtrate 1 and filtrate 2 under reduced pressure respectively at 70 deg.C under-0.02 MPa until the relative density is about 1.17 to obtain fluid extract 1 and fluid extract 2, weighing 3300g of fluid extract 1, adding 255g of mannitol, mixing, refrigerating at 15 deg.C for 38min, weighing 1050g of fluid extract 2, and standing at normal temperature for 38 min;

s5 mixing 3300g of fluid extract 1 and 255g of fluid extract 2, stirring for 12min, preheating with hot air at 30 deg.C, spray drying at 65 deg.C and spray speed of 1.5L/min, air inlet temperature of 150 deg.C and air flow rate of 4500m³H, blowing air at the temperature of 85 ℃ to obtain clear paste powder, adding 210g of sodium cyclamate powder, uniformly mixing and granulating to obtain granules;

s6 hot air drying the obtained granules at 80 deg.C for 60min, and mixing to obtain the final product.

Comparative example 1

The preparation method of the infantile lung-heat cough and asthma granule according to the embodiment 4 is characterized by comprising the following steps: in the steps S1 and S2, the mass ratio is 24: 10: 10: 10, weighing 2400g of gypsum, 1000g of isatis root, 1000g of radix ophiopogonis and 1000g of houttuynia cordata, crushing to obtain crushed materials, and mixing the crushed materials in a mass ratio of 3: 10: 6: 10, weighing 300g of liquorice, 1000g of honeysuckle, 600g of bitter apricot seeds and 1000g of rhizoma anemarrhenae, adding the crushed material obtained in the step S1 and 31600g of water with the temperature of 85 ℃, uniformly stirring, heating to 95 ℃, decocting for 6 hours, cooling and filtering to obtain filtrate 1.

Comparative example 2

The preparation method of the infantile lung-heat cough and asthma granule according to the embodiment 4 is characterized by comprising the following steps: in the step S4, filtrate 1 and filtrate 2 are mixed, and concentrated under reduced pressure to obtain fluid extract, and 210g mannitol is added.

Comparative example 3

The preparation method of the infantile lung-heat cough and asthma granule according to the embodiment 4 is characterized by comprising the following steps: in the step S4, refrigeration is not performed.

Comparative example 4

The preparation method of the infantile lung-heat cough and asthma granule according to the embodiment 4 is characterized by comprising the following steps: and in the step S4, refrigerating at 5 ℃ for 20 min.

Comparative example 5

The preparation method of the infantile lung-heat cough and asthma granule according to the embodiment 4 is characterized by comprising the following steps: in the step S5, hot air preheating is not performed.

1. Product inspection results

(1) The particle for treating lung heat cough and asthma of children prepared in the embodiments 1 to 4 and the comparative examples 1 to 5 is subjected to detection of the particle size, the solubility, the content of ephedrine, amygdalin and baicalin according to the 'Chinese pharmacopoeia' 2020 edition, and the detection results are shown in table 1.

TABLE 1

Experiments show that the infant lung heat cough and asthma granules prepared in the embodiments 1-4 of the invention have ephedrine content of more than 0.55mg/g, phillyrin content of more than 0.27mg/g, baicalin content of more than 12.44mg/g and granularity of 3.5-5.5%, are completely dissolved within 1min, are slightly turbid, have no coke breeze, are brown granules, are fresh and sweet, have stable product quality, and meet the quality standard.

The ephedrine, phillyrin and baicalin contents of the comparative example 1 are lower; comparative example 2 the clear paste is not separately concentrated, the prepared granules are slightly turbid, and the granularity is larger; comparative example 3, which is slightly sweet in mouthfeel and has no fresh and sweet mouthfeel, shows that sweet molecules of mannitol can be left in the fluid extract after long-time refrigeration; comparative example 4 adopts lower temperature refrigeration, the taste is slightly sweet, but the content of ephedrine and phillyrin is lower, the lower temperature influences the internal structure shape of the clear paste, the preparation and the forming are not easy, the particle size is large, and the yield is low; comparative example 5 has a poor granularity, the hot air preheating further softens the interior of the clear paste, the hot air accelerates intermolecular movement, reduces the viscosity of the clear paste, ensures that the spray-dried particles are uniform and are easy to mix with auxiliary materials to form a good granularity.

(2) Stability study: the particles for lung heat cough and asthma of children prepared in examples 1 to 4 and comparative examples 1 to 5 were subjected to thin-layer identification (ephedra, forsythia, scutellaria baicalensis), moisture (%), and ephedrine content detection according to the "chinese pharmacopoeia" 2020 edition for 6 months, and the detection results are shown in table 2.

TABLE 2

Experimental results show that the particles for treating lung-heat cough and asthma of children prepared in the embodiments 1-4 of the invention have the advantages that the thin-layer identification of the ephedra herb, the forsythia fruit and the scutellaria root meets the product quality specification, the water content is 1.59-1.68%, the ephedrine content is more than 0.51mg/g, and the particle stability is good.

Comparative example 1 thin layer identification of spot blur of herba Ephedrae, fructus forsythiae, and Scutellariae radix; the scutellaria baicalensis of comparative example 2 is blurred in spots; comparative example 3 the particles are more stable; spots of the ephedra, the forsythia and the scutellaria baicalensis of the comparative example 4 are blurred; comparative example 5 has a higher water content, a higher reduction in ephedrine content, and a lower granule stability.

2. Therapeutic effects

(1) Data: the 42 children were randomized into 2 groups. Observation group (n ═ 21) 12 men, 9 women, age 3-7 years; the control group (n ═ 21) was 14 men and 7 women, aged 3-8 years. The general data of sex, age, course of disease, etc. of two groups of children patients are statistically processed, and the difference has no statistical significance (P is more than 0.05), and has comparability;

(2) diagnostic criteria: referring to the diagnosis standard of pneumonia, asthma and cough in the 'traditional Chinese medicine disease diagnosis curative effect standard', the clinical manifestations of the pneumonia, asthma and cough are fever, cough, expectoration, shortness of breath, auscultation with special sounds such as blister sound, asthma and singing sound, and the increase of the number of leucocytes is detected by blood routine; patients with drug allergy were excluded;

(3) the treatment method comprises the following steps: patients in control group were treated with commercially available infantile lung heat cough and asthma granule (sunflower pharmaceutical industry, national standard Z30205235, specification 3g x 6 bags/box); the experimental group takes the particles for treating the cough and asthma of the lung heat of the children prepared in the embodiment 4 of the invention; the composition is taken after meals every day, and during treatment, people are careful not to catch cold, and the composition is regularly worked and stopped, and the diet is light. Children under 3 years old, 3 g/time and 3 times/d; 3-7 years old children, 3 g/time and 4 times/d; children over 7 years old, 6 g/time, 3 times/d; one week is a treatment course, and the recovery condition of the patient is observed every day;

(4) evaluation indexes are as follows: observing the treatment conditions of the two groups of patients, and recording the days when the fever of the patients subsides, the days when the cough disappears, the days when the wheeze disappears and the adverse reactions such as vomit, diarrhea, stomach discomfort and the like of the patients, wherein the treatment conditions are shown in a table 3;

(5) the data processing method comprises the following steps: significance analysis was performed using SPSS 17.0 software.

TABLE 3

Remarking: denotes p <0.05

The treatment results show that the fever resolution time and the cough resolution time of the experimental group are shorter than those of the control group, and the statistical difference (p is less than 0.05) exists between the two groups.

In conclusion, the invention controls the time and temperature of soaking and boiling the traditional Chinese medicine in hot water, the mannitol is added into the clear paste, and the way of refrigerating for a long time and preheating clear paste powder by hot air is adopted, so that the prepared granules for treating the cough and asthma with the lung heat in the children have fresh and sweet taste, good stability, high content of effective components and good curative effect, and the recovery time of disease cure is accelerated.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. A preparation method of the infantile lung-heat cough and asthma particle is characterized in that: the preparation method comprises the following steps:

step S1: crushing gypsum, radix isatidis, radix ophiopogonis and herba houttuyniae, and sieving by a sieve of 60-80 meshes to obtain a mixed crushed material;

step S2: soaking liquorice, honeysuckle, bitter apricot kernels and rhizoma anemarrhenae in water of 50-60 ℃, wherein the weight ratio of the material liquid is 1: 4-6; heating to 80 ~ 90 ℃ and carrying out first boiling, the mixed crushed material and 80 ~ 90 ℃ water of step S1 are added to the boiling in-process, and the stirring is even, the weight ratio of mixed crushed material and water is 1: 3-5, standing after the boiling is finished, heating to 90-95 ℃ for second boiling, cooling, and filtering to obtain a filtrate 1;

step S3: pulverizing herba Ephedrae, fructus forsythiae and Scutellariae radix, soaking in water at a weight ratio of 1: 6-8; heating to 90-95 ℃ for boiling, filtering, adding water for repeatedly boiling for 2-3 times, and combining the filtrates to obtain a filtrate 2;

step S4: respectively concentrating the filtrate 1 and the filtrate 2 under reduced pressure to obtain fluid extract 1 and fluid extract 2, adding mannitol into the fluid extract 1, mixing, refrigerating at 10-20 deg.C for 30-40 min, and standing the fluid extract 2 at normal temperature for 30-40 min;

step S5: mixing the fluid extract 1 and the fluid extract 2, stirring, preheating with hot air, spray drying to obtain fluid extract powder, adding sodium cyclamate powder, mixing, and granulating to obtain granules;

step S6: and drying the obtained particles by hot air, and uniformly mixing to obtain a finished product.

2. The method for preparing particles for treating cough and asthma with lung heat in children according to claim 1, wherein: the mass ratio of the gypsum to the radix isatidis to the radix ophiopogonis to the houttuynia cordata to the liquorice to the honeysuckle to the bitter apricot kernel to the rhizoma anemarrhenae is 24: 10: 10: 10: 3: 10: 6: 10.

3. the method for preparing particles for treating cough and asthma with lung heat in children according to claim 1, wherein: the mass ratio of the ephedra, the forsythia and the scutellaria is 3: 10: 10.

4. the method for preparing particles for treating cough and asthma with lung heat in children according to claim 1, wherein: in the step S2, the soaking time is 2-4 hours, and the first boiling time is 1-3 hours; standing for 2-4 hours after the first boiling is completed, wherein the second boiling time is 2-4 hours.

5. The method for preparing particles for treating cough and asthma with lung heat in children according to claim 1, wherein: in the step S3, the temperature of the added water is 60-80 ℃, the soaking time is 2-4 hours, and the boiling time is 4-6 hours each time.

6. The method for preparing particles for treating cough and asthma with lung heat in children according to claim 1, wherein: in the step S4, the concentration conditions are that the temperature is 65-75 ℃, the pressure is-0.02-0.04 MPa, and the concentration is carried out until the relative density is 1.10-1.21.

7. The method for preparing particles for treating cough and asthma with lung heat in children according to claim 1, wherein: in the step S5, stirring is carried out for 10-15 min, and the hot air preheating temperature is 25-35 ℃.

8. The method for preparing particles for treating cough and asthma with lung heat in children according to claim 1, wherein: in the step S5, spray drying conditions are that the temperature is 60-70 ℃, the spraying speed is 1-2L clear paste/min, the air inlet temperature is 140-160 ℃, and the air flow is 4000-5000 m³And h, the air outlet temperature is 80-90 ℃.

9. The method for preparing particles for treating cough and asthma with lung heat in children according to claim 1, wherein: the weight parts of the clear paste 1, the clear paste 2, the mannitol and the sodium cyclamate powder are 18-24 parts of clear paste 1, 4-10 parts of clear paste 2, 1.5-2.0 parts of mannitol and 1.2-1.7 parts of sodium cyclamate powder.

10. The method for preparing particles for treating cough and asthma with lung heat in children according to claim 1, wherein: in the step S6, the hot air drying condition is that the temperature is 70-90 ℃, and the drying time is 50-70 min.