CN108553578A - A kind of preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma - Google Patents
A kind of preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma Download PDFInfo
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- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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Abstract
The invention discloses a kind of preparation methods of granules for curing infantile lung pathogenic heat and cough and asthma：Weigh the Chinese medicine of following weight：Chinese ephedra 300, semen armeniacae amarae 600, gypsum 2400, Radix Glycyrrhizae 300, honeysuckle 1000, Fructus Forsythiae 1000, rhizoma anemarrhenae 1000, radix scutellariae 1000, Radix Isatidis 1000, Radix Ophiopogonis 1000 and cordate houttuynia 1000.After above-mentioned ten a herbs material at twice water extraction, merging filtrate, filtrate concentrates, Chinese ephedra content is measured after spray drying, the cane sugar powder of corresponding parts by weight is added according to the Chinese ephedra content measured, the Chinese ephedra content of the 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma made is 1.80~1.90mg/ bags, and prepared granules for curing infantile lung pathogenic heat and cough and asthma Chinese ephedra stable content has significant cough-relieving and antiasthmatic effect.
Description
Technical field
The present invention relates to pharmaceutical preparation preparation fields, and in particular to a kind of preparation side of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma
Method.
Background technology
Existing infantile lung heat cough and asthma preparation is usually with Chinese ephedra, semen armeniacae amarae, gypsum, Radix Glycyrrhizae, honeysuckle, Fructus Forsythiae, knows
Mother, radix scutellariae, Radix Isatidis, Radix Ophiopogonis and ten a herb material of cordate houttuynia are to have clearing heat and detoxicating, ventilating the lung and relieving cough, change made of raw material
The effect of phlegm is relievingd asthma, clinical practice prove, for flu, bronchitis, asthmatic bronchitis, Bronchopneumonia category phlegm heat
Stopping up lung disease person has the effect of highly significant.
Infantile lung heat cough and asthma preparation is mostly to be recorded for the 18th page 14 according to the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation
Infantile lung heat instant powder for asthma and cough quality standard (WS3-B-3361-98) prepare granule.
The preparation method of traditional granules for curing infantile lung pathogenic heat and cough and asthma is：30g Chinese ephedras, 60g semen armeniacae amaraes, 240g, which are weighed, by recipe quantity gives birth to stone
Cream, 30g Radix Glycyrrhizaes, 100g honeysuckles, 100g Fructus Forsythiaes, 100g rhizoma anemarrhenaes, 100g radix scutellariaes, 100g Radix Isatidis, 100g Radix Ophiopogonis and 100g fishes
Raw meat ten a herb materials of grass add water to cook 2 times, and 1 hour every time, collecting decoction filtered, the clear cream of filtrate concentration, by 1 weight of clear cream
Amount part, 0.05 parts by weight of 0.27 parts by weight of dextrin and sodium cyclamate proportioning mixing after particle is made, be sieved, dispense to get small
Youngster's lung heat cough and asthma particle.
Above-mentioned clear cream is that water extracts product, and manufactured granules for curing infantile lung pathogenic heat and cough and asthma in target level of product quality due to not can guarantee
Crude drug amount is stablized in finished product, causes product epheday intermedia to differentiate that item is unstable, Chinese ephedra content cannot control, and cause the quality of the pharmaceutical preparations not
Stablize, product qualification rate is relatively low.
Application No. is the Chinese invention patents of 201010134951.X to disclose a kind of preparation of granules for curing infantile lung pathogenic heat and cough and asthma
Ten a herb materials of certain part by weight are divided to two groups after water extracts by method, and merging filtrate filters, and filtrate is concentrated to give clear cream,
By particle is made after the proportioning mixing of 0.05 parts by weight of 1 parts by weight of clear cream, 0.27 parts by weight of dextrin and sodium cyclamate, it is after dry
Obtain granules for curing infantile lung pathogenic heat and cough and asthma.This method strictly controls the water consumption during water extraction medicinal material, and according to different
Character of medicinal material is grouped extraction, and the granules for curing infantile lung pathogenic heat and cough and asthma scutelloside of preparation differentiates that item is stable and meets the requirements of the standard.It should
Clear cream, dextrin, sodium cyclamate are mixed evenly to prepare particle by invention by weight 1: 0.27: 0.05 proportioning, are likely to result in institute
It is unstable to obtain active constituent content in product, and then influences the therapeutic effect of product.
Invention content
The object of the present invention is to provide a kind of 4 grams of dress Lungs of Children heat-syndrome coughs by active ingredient control in a certain range
Breathe heavily the preparation method of particle so that the drug effect for 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma being prepared significantly improves.
A kind of preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma, weighs the Chinese medicine of following parts by weight：
It is characterised in that it includes following steps：
(1) it will add water to cook 2 times, decoct 1~4 hour every time, the dosage of first time water after described ten simply medicinal material mixing
Dosage for 8~12 times of medicinal material total weight amounts, second of water is 6~10 times of amounts of medicinal material total weight, merges carrying of obtaining for 2 times
Liquid is taken, filtrate is spare after filtering；
(2) obtained filtrate is concentrated into the clear cream that relative density is 1.06~1.19, after clear cream spraying drying powder-forming
Chinese ephedra content is measured, cane sugar powder is added according to the Chinese ephedra content measured, particle is made in mixing；
(3) it will be dispensed by 4g/ bags after obtained particle drying, control Chinese ephedra content is 1.80~1.90mg/ bags, and institute is made
The 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma stated.
Chinese ephedra has the function of sweating cold dispelling, freeings lung and relieving asthma, inducing diuresis for removing edema, is mainly used for anemofrigid cold, uncomfortable in chest to breath with cough, wind
Water edema.Containing Multiple components such as alkaloid, flavones, flavane, tannin, volatile oil, organic acid, polysaccharide in known Chinese ephedra, wherein
The content of ephedrine is higher, predominantly amphetamine alkaloid, which, which is considered as Chinese ephedra all the time, has work(of relievining asthma
The active ingredient of energy, what is detached at present has ephedrine, d-pseudo-ephedrine, ephedine, Chinese ephedra oxane etc.；Flavones ingredient master
Have：Apiolin, Kaempferol, Quercetin, leucocyanidin etc..In addition, also containing polysaccharide, organic acid, tannin, Huang in Chinese ephedra
The ingredients such as ketone glucoside, dextrin, starch, pectin, cellulose, glucose.
Modern pharmacological research confirms：Ephedrine is the active ingredient that Chinese ephedra is relievingd asthma, and ephedrine has similar adrenergic friendship
Feel innervation, it can directly excitement adrenocepter, and promotion norepinephrine neurotransmitter indirectly in body
Release, while significantly excited maincenter.Other reported pharmacological actions of Chinese ephedra also have sweating, diuresis, antibechic, relieving asthma, resist
Allergy, increase blood pressure, anticoagulation, immunosupress, it is anti-oxidant the effects that.
Since Chinese ephedra has the effects that preferable cough-relieving, relievings asthma, radiates, the present invention passes through the clear cream being concentrated to give specific
Drying process spray shaping be dry powder, the Chinese ephedra content measured in gained dry powder matches cane sugar powder, and it is controlled to obtain Chinese ephedra amount
Make 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma in most effective range.
The present invention simplifies original technique, protects directly by clear cream drying spray shaping to be mixed again with cane sugar powder after dry powder
The crude drug amount and yield of final products have been demonstrate,proved, has been provided convenience for follow-up granulation, is avoided and add multiple auxiliary materials in the prior art
The problem of caused influence final products crude drug amount and yield.
Products obtained therefrom epheday intermedia stable content of the present invention, can fully ensure that the therapeutic effect of product, avoids the prior art
In only add the technical problem that active constituent content is unstable in the product caused by auxiliary material according to fixed mixing ratio.
Granules for curing infantile lung pathogenic heat and cough and asthma epheday intermedia content can excessively cause the crowd of taking certain addiction feature, and product epheday intermedia
Content is excessively few to be then not achieved best therapeutic effect, therefore the present invention is selected the Chinese ephedras of 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma of gained
Content is controlled at 1.80~1.90mg/ bags.
In order to further increase the therapeutic effect of product crude drug amount and product, preferably prepare according to the following steps：
(1) it will add water to cook 2 times, decoct 1~3 hour every time, the dosage of first time water after described ten simply medicinal material mixing
Dosage for 9~11 times of medicinal material total weight amounts, second of water is 7~9 times of amounts of medicinal material total weight, merges carrying of obtaining for 2 times
Liquid is taken, filtrate is spare after filtering；
(2) obtained filtrate is concentrated into the clear cream that relative density is 1.10~1.17, after clear cream spraying drying powder-forming
Chinese ephedra content is measured, cane sugar powder is added according to the Chinese ephedra content measured, particle is made in mixing；
(3) it will be dispensed by 4g/ bags after obtained particle drying, control Chinese ephedra content is 1.85~1.90mg/ bags, and institute is made
The 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma stated.
Preferably, the filtrate in the step (2), which is concentrated in dual-effect energy-saving concentrator, carries out, and thickening temperature is 60~70
DEG C, concentration vacuum degree is -0.06~-0.08MPa.
Concentration is to save working hour to improve extract yield and progress under these conditions, is improved in gained clear cream effectively
The content of ingredient, while further ensuring the therapeutic effect of product.
Preferably, spray drying carries out in spray dryer in the step (2), and control clear cream temperature is 60~75
DEG C, motor speed is 5~10HZ, and inlet air temperature is 140~160 DEG C, and leaving air temp is 80~90 DEG C, is effectively controlled stream
Amount, ensure that spraying be smoothed out and spray shaping is dry powder, lay a good foundation for subsequent production process.
Preferably, drying temperature when dry in the step (3) is 75~85 DEG C, and drying time is 1~3 hour, this
It is to ensure the content of active ingredient in the ultimate yield of product, moisture and product.
This product specification is per packed 4g；Usage and dosage is：Boiling water is taken after mixing it with water, three one full year of life with 4g next time, 3 times a day；Three
One full year of life with last 4g, 4 times a day；Seven one full year of life with last 8g, 3 times a day.
Crude drug of the present invention is described in detail below：
Chinese ephedra is Ephedraceae plant ephedra sinica Ephedra sinica Stapf, epheday intermedia Ephedra intermedia
The drying herbaceous stem stem of Schrenk et C.A.Mey. or ephedra equisetina Ephedra equisetina Bge..Autumn taps green
Herbaceous stem stem, dry.Ephedra sinica is in elongated cylindrical, few branch；1~2mm of diameter.Some a small amount of brown woody stems of band.Surface
Light green has thin longitudinal ridge line to yellow green, and that touches micro- has harsh feeling.Section is apparent, 2~6cm of internode length.There is film quality scale leaf on section,
Long 3~4mm；(dilute 3), sharp triangle, apex canescence, contrary flexure, base portion are unified into tubular, rufous to sliver 2.Body is light, and matter is crisp,
Frangibility, section are slightly in fibroid, periphery green-yellow, marrow rufous, subcircular.Gas micro-perfume, puckery, slight bitter.Epheday intermedia is more
Branch, 1.5~3mm of diameter, there is harsh feeling.2~6cm of internode length, film quality scale leaf 2~3mm of length, sliver 3 (dilute 2), the sharp point of apex,
Section marrow is round in triangular shape.Ephedra equisetina is compared with multi-branched, 1~1.5mm of diameter, no harsh feeling.1.5~3cm of internode length.Film
Matter scale leaf grows 1~2mm；(dilute 3), top are short triangle to sliver 2, and canescence, apex mostly not contrary flexure, base portion brownish red is to dark brown
Color.
Semen armeniacae amarae is rosaceous plant ansu apricot Prunus armeniaca L.var.ansu Maxim., Siberia apricot
Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or apricot Prunus armeniaca
L. dry mature seed.Summer harvests ripening fruits, removes pulp and nucleocapsid, takes out seed, dries.This product is in flat heart,
Long 1~1.9cm, wide 0.8~1.5cm, 0.5~0.8cm of thickness.Surface yellowish-brown is to dark-brown, and one end point, another end blunt circle is plump,
It is left-right asymmetry.There is short-term shape hilum in tip side, has most dark-brown veins upwards at nose circle chalaza.Kind thin skin, cotyledon
2, milky is High oleic.It is odorless, bitter.
Gypsum refers to natural dihydrate gypsum (containing two hydrones), main chemical compositions：CaSO4·nH2O.For threadiness
Aggregate, in long blocky, plate-like or irregular bulk.White, canescence or faint yellow, what is had is translucent.Weight, matter is soft,
Vertical section has spun silk sample gloss, and gas is micro-, lightly seasoned.(heat-clearing and fire-clearing drug) is pungent, sweet, is slightly cold；It attaches to the lung and stomach meridians.
Radix Glycyrrhizae is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix
The drying root and rhizome of Glycyrrhizainflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..Spring, autumn two
Season excavates, and removes fibrous root, dries.Root is cylinder, long 25~100cm, 0.6~3.5cm of diameter.Crust is elastic to differ.Surface
Rufous or taupe brown have significant vertical wrinkle, rill, hole skin and sparse radicula trace.Matter is solid, and section shows slightly fibroid,
Yellow-white, mealiness, cambium ring is apparent, and ray irradiation shape, some has crack.Rhizome is cylinder, and there is a bud scar on surface, in section
There is marrow in portion.Gas is micro-, sweet and special.
Honeysuckle is caprifoliaceae plant honeysuckle Lonicera japonica Thunb., lonicera hypoglauca miq Lonicera
Hypoglau-ca Miq., Honeysuckle flower Lonicera confus μ DC. or hair style honeysuckle Lonicera dasystyla
Rehd. dry flower or with the flower just opened.The flowers are in blossom puts preceding harvesting for early summer, dry.Appearance yellow or yellowish-brown are had pubescence
And glandular hairs, the calyx that base portion has green tiny, 5 split, sliver triangle, hairless.It splits bud and then sees 5 pieces of stamens and 1 piece of gynoecium.
Corolla lip, Pistil And Stamen are stretched out in palpus shape.Honeysuckle is in rodlike, upper coarse and lower fine, slightly curved song, under long 2~3cm, upper diameter about 3mm
Portion's diameter about 1.5mm.Surface yellow-white or green white (it is gradually deep to store long color), it is close by pubescence.Accidental lobate bract.Calyx is green
Color, apex 5 are split, and sliver hairiness is about 2mm.Opening person's corolla tubular, two lip of apex；5, stamen, invests barrel, yellow；
Gynoecium 1, ovary is hairless.Gas faint scent, lightly seasoned, slight bitter.Lonicera hypoglauca miq grows 2.5~4.5cm, 0.8~2mm of diameter.Surface is yellowish-white
To yellowish-brown, hairless or thin hair.Calyx tube is hairless, and apex 5 is split, sliver Yangtze River Delta shape, hair.Opening person's corolla lower lip inverts.
Style is hairless.Honeysuckle flower grows 1.6~3.5cm, 0.5~2mm of diameter.Calyx tube and corolla are close by canescence hair, ovary hairiness.Mao Hua
Column honeysuckle grows 2.5~4cm, 1~2.5mm of diameter.The faint yellow micro-strip purple in surface, it is hairless.The short triangle of calyx lobes.Opening person
Upper lip of corolla is often irregular, style lower part Duo Mi villosities.
Fructus Forsythiae is the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.Autumn fruit
It is harvested when just ripe still band green, removes impurity, cook, dry, practise and claim " blueness sticks up "；It harvests, dries when fruit is well-done, remove impurity elimination
Matter is practised and claims " sticking up always ".This product is in long avette to oval, slightly flat, long 1.5~2.5cm, 0.5~1.3cm of diameter.Surface, which has, does not advise
The fleck of vertical wrinkle and most protrusions then, respectively there is 1 apparent longitudinal furrow on two sides.Top tax point, base portion have small carpopodium or
It falls off." blueness sticks up " does not crack mostly, the green and brown color in surface, and raised canescence fleck is less；Matter is hard；Seed is most, yellow green, carefully
Long, there is wing in side." sticking up always " cracks from top or is cleaved into two valves, surface yellowish-brown or rufous, and inner surface is mostly light yellowish brown,
Smoothly, has a mediastinum；Matter is crisp；Seed brown, has fallen off more.Gas micro-perfume, bitter.
Rhizoma anemarrhenae is the dry rhizome of liliaceous plant rhizoma anemarrhenae Anemarrhena asphodeloides Bge..Spring, autumn two
Season excavates, and removes fibrous root and silt, dries, and practises and claims " RHIZOMA ANEMARRHENAE with peet "；Or crust is removed, it dries.This product be in strip, microbend,
It is slightly flat, occasionally there is branch, long 3~15cm, 0.8~1.5cm of diameter, there is the residual trace of lurid cauline leaf in one end.Surface yellowish-brown is to palm fibre
Color has a chase above, has a compact arranged ring joint, the remaining phyllopodium of dense yellowish-brown on section, above two lateral rhizomes
Growth；It swells below and slightly shrinkage, and has dotted trace of depressions or protrusions.Matter is hard, frangibility, section yellow-white.Gas is micro-, taste
Slightly sweet, slightly bitter, the band viscosity chewed.
Radix scutellariae is the dry root of labiate radix scutellariae Scutellaria baicalensis Georgi.Spring, Qiu Erji
Excavation removes fibrous root and silt, hits tertia after solarization, dry.This product is in cone, distortion, long 8~25cm, 1~3cm of diameter.
Surface brown color or buff have sparse excipuliform radicula trace, and top is rougher, there is the vertical wrinkle of distortion or irregular reticulate pattern,
Rift grain and scabriculous are arranged at lower part.Matter is hard and crisp, frangibility, section yellow, intermediate rufous；The old dry and decayed shape or hollow in root center is in
Burgundy or brownish black.Gas is micro-, bitter.
Radix Isatidis is the dry root of cruciferae isatis Isatis indigotica Fort..Autumn excavates, and removes
Silt dries.It is cylinder, it slightly distorts, long 10-20cm diameters 0.5-1em, surface light lark or light brown yellow have vertical wrinkle
The horizontally long hole skin sample protrusion of line and taproot trace, root head slightly expand, and body is real, and matter is slightly soft, and section skin zone yellow-white, woody part yellow, gas is micro-,
It is bitter after taste is slightly sweet.
Radix Ophiopogonis is the dried root of liliaceous plant Radix Ophiopogonis Ophiopogon japonicus (Thunb.) Ker-Gawl..
Summer excavates, and cleans, is exposed to the sun, banks up repeatedly, until doing very likely, removes fibrous root, dry.This product is in spindle, and both ends are slightly sharp, long
1.5~3cm, 0.3~0.6cm of diameter.Surface yellow-white is light yellowish-white, there is thin longitudinal grin.Matter is flexible, section yellow-white, translucent,
Center pillar is tiny.Gas micro-perfume, sweet in flavor, slight bitter.
Cordate houttuynia is the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..Summer
The luxuriant flower spike of cauline leaf is tapped when more, is removed impurity, is dried.Stem is oblate, shrinkage and be bent, long 20-30cm；Surface yellowish-brown,
Has vertical rib, section is apparent, has fibrous root remaining at the section of lower part；Matter is crisp, frangibility.Leaf alternate.More shrinkages.It is heart-shaped after flattening, long 3-5,
Wide 3-4.5cm；Dark green above or yellow green, below green and brown color or taupe brown；Petiole is elongated, and base portion synthesizes sheath shape with stipule.Fringe
Locusta Xiang Sheng.Rub with the hands it is broken bear the odor of fish, taste micro-puckery.It is more with leaf, color is green, has flower spike, fishy smell.
Compared with prior art, the present invention having the advantages that：
(1) corresponding weight is added by the Chinese ephedra content in the clear cream after measurement spraying drying powder-forming in the method for the present invention
Part cane sugar powder, so as to get 4 grams dress granules for curing infantile lung pathogenic heat and cough and asthma Chinese ephedra contents be 1.80~1.90mg/ bags, significantly improve
The cough-relieving of product, antiasthmatic effect.
(2) clear cream being concentrated to give is dry powder by specific drying process spray shaping by the present invention, then will directly be done
Powder is mixed to prepare 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma, the crude drug for simplifying technological process, ensure that final products with cane sugar powder
Amount is provided convenience for follow-up granulation.
(3) the method for the present invention it is easy to operate, it is with short production cycle, without special equipment, at low cost, high income is suitable for work
Industry metaplasia is produced.
Specific implementation mode
Embodiment 1
Weigh the Chinese medicine of following weight：
It prepares according to the following steps：
(1) it will add water to cook 2 times after above ten simply medicinal material mixing, decoct 1 hour every time, the dosage of first time water is medicine
The dosage of 8 times of amounts of material total weight, second of water is 6 times of amounts of medicinal material total weight, merges 2 extracting solutions, filtrate after filtering
It is spare；
(2) obtained filtrate is concentrated in dual-effect energy-saving concentrator, thickening temperature is 60 DEG C, concentrates vacuum degree
For -0.06MPa, the clear cream that relative density is 1.10 has been obtained, in motor speed has been 5HZ by 65 DEG C of clear cream, inlet air temperature is
140 DEG C, leaving air temp measures Chinese ephedra content after being spray-dried under conditions of being 80 DEG C, adds 2632g cane sugar powders, mixing, system
Obtain particle；
(3) it after obtained particle is 1 hour dry at 75 DEG C, is dispensed by 4g/ bags, it is 1.88mg/ to measure Chinese ephedra content
Bag obtains 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma.
Embodiment 2
Weigh the Chinese medicine of following weight：
It prepares according to the following steps：
(1) it will add water to cook 2 times after above ten simply medicinal material mixing, decoct 1 hour every time, the dosage of first time water is medicine
The dosage of 9 times of amounts of material total weight, second of water is 7 times of amounts of medicinal material total weight, merges 2 extracting solutions, filtrate after filtering
It is spare；
(2) obtained filtrate is concentrated in dual-effect energy-saving concentrator, thickening temperature is 60 DEG C, concentrates vacuum degree
For -0.07MPa, the clear cream that relative density is 1.11 has been obtained, in motor speed has been 7HZ by 60 DEG C of clear cream, inlet air temperature is
150 DEG C, leaving air temp measures Chinese ephedra content after being spray-dried under conditions of being 85 DEG C, adds 2712g cane sugar powders, mixing, system
Obtain particle；
(3) it after obtained particle is 1 hour dry at 80 DEG C, is dispensed by 4g/ bags, it is 1.87mg/ to measure Chinese ephedra content
Bag obtains 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma.
Embodiment 3
Weigh the Chinese medicine of following weight：
It prepares according to the following steps：
(1) it will add water to cook 2 times after above ten simply medicinal material mixing, decoct 1 hour every time, the dosage of first time water is medicine
The dosage of 10 times of amounts of material total weight, second of water is 8 times of amounts of medicinal material total weight, merges 2 extracting solutions, filtrate after filtering
It is spare；
(2) obtained filtrate is concentrated in dual-effect energy-saving concentrator, thickening temperature is 70 DEG C, concentrates vacuum degree
For -0.08MPa, the clear cream that relative density is 1.12 has been obtained, in motor speed has been 8HZ by 75 DEG C of clear cream, inlet air temperature is
150 DEG C, leaving air temp measures Chinese ephedra content after being spray-dried under conditions of being 85 DEG C, adds 2928g cane sugar powders, mixing, system
Obtain particle；
(3) it after obtained particle is 1.5 hours dry at 82 DEG C, is dispensed by 4g/ bags, measuring Chinese ephedra content is
1.83mg/ bags, obtain 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma.
Embodiment 4
Weigh the Chinese medicine of following weight：
It prepares according to the following steps：
(1) it will add water to cook 2 times after above ten simply medicinal material mixing, decoct 1 hour every time, the dosage of first time water is medicine
The dosage of 9 times of amounts of material total weight, second of water is 7 times of amounts of medicinal material total weight, merges 2 extracting solutions, filtrate after filtering
It is spare；
(2) obtained filtrate is concentrated in dual-effect energy-saving concentrator, thickening temperature is 75 DEG C, concentrates vacuum degree
For -0.06MPa, the clear cream that relative density is 1.17 has been obtained, in motor speed has been 10HZ by 70 DEG C of clear cream, inlet air temperature is
160 DEG C, leaving air temp measures Chinese ephedra content after being spray-dried under conditions of being 80 DEG C, adds 2657g cane sugar powders, mixing, system
Obtain particle；
(3) it after obtained particle is 1.5 hours dry at 75 DEG C, is dispensed by 4g/ bags, measuring Chinese ephedra content is
1.85mg/ bags, obtain 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma.
Embodiment 5
Weigh the Chinese medicine of following weight：
It prepares according to the following steps：
(1) it will add water to cook 2 times after above ten simply medicinal material mixing, decoct 1 hour every time, the dosage of first time water is medicine
The dosage of 9 times of amounts of material total weight, second of water is 8 times of amounts of medicinal material total weight, merges 2 extracting solutions, filtrate after filtering
It is spare；
(2) obtained filtrate is concentrated in dual-effect energy-saving concentrator, thickening temperature is 70 DEG C, concentrates vacuum degree
For -0.08MPa, the clear cream that relative density is 1.17 has been obtained, in motor speed has been 9HZ by 75 DEG C of clear cream, inlet air temperature is
160 DEG C, leaving air temp measures Chinese ephedra content after being spray-dried under conditions of being 80 DEG C, adds 2684g cane sugar powders, mixing, system
Obtain particle；
(3) it after obtained particle is 1 hour dry at 78 DEG C, is dispensed by 4g/ bags, it is 1.86mg/ to measure Chinese ephedra content
Bag obtains 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma.
Comparative example 1
Weigh the Chinese medicine of following weight：
It prepares according to the following steps：
(1) it will add water to cook 2 times after above ten simply medicinal material mixing, decoct 1 hour every time, the dosage of first time water is medicine
The dosage of 9 times of amounts of material total weight, second of water is 8 times of amounts of medicinal material total weight, merges 2 extracting solutions, filtrate after filtering
It is spare；
(2) obtained filtrate is concentrated in dual-effect energy-saving concentrator, thickening temperature is 70 DEG C, concentrates vacuum degree
For -0.08MPa, the clear cream that relative density is 1.17 is obtained, by clear cream, dextrin, sodium cyclamate by weight 1: 0.27: 0.05
Proportioning be mixed evenly to prepare particle, be sieved, by 4g/ bag packing, measure Chinese ephedra content be 1.70mg/ bags, obtain Lungs of Children heat-syndrome cough
Breathe heavily particle.
Comparative example 2
Weigh the Chinese medicine of following weight：
It prepares according to the following steps：
(1) it will add water to cook 2 times after above ten simply medicinal material mixing, decoct 1 hour every time, the dosage of first time water is medicine
The dosage of 8 times of amounts of material total weight, second of water is 6 times of amounts of medicinal material total weight, merges 2 extracting solutions, filtrate after filtering
It is spare；
(2) obtained filtrate is concentrated in dual-effect energy-saving concentrator, thickening temperature is 60 DEG C, concentrates vacuum degree
For -0.06MPa, the clear cream that relative density is 1.10 is obtained, by clear cream, dextrin, sodium cyclamate by weight 1: 0.27: 0.05
Proportioning be mixed evenly to prepare particle, be sieved, by 4g/ bag packing, measure Chinese ephedra content be 1.60mg/ bags, obtain Lungs of Children heat-syndrome cough
Breathe heavily particle.
Chinese ephedra content in all of above embodiment and comparative example is all according to the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation
The 6th page 14 infantile lung heat instant powder for asthma and cough quality standard (WS recorded3- B-3361-98) and《State food drug surveilance
Manage general bureau's standard》Method in YBZ00822015 detects to obtain.
Qualified ICR kinds mouse 100, weight 11-13g is selected, is randomly divided into 10 groups, every group 10, half male and half female.It presses
Dosage shown in following table is administered, and 1 time a day, for three days on end, control group gives same volume deionized water.In 40 minutes after the last administration,
Every animal is respectively placed in spraying device, a concentration of 12.5% ammonium hydroxide is at the uniform velocity sprayed into 5 seconds with lured to cough to draw and breathes heavily instrument, and instrument is certainly
Dynamic record mouse cough incubation period, and the number of coughing in 3 minutes that counts.By each group averaging of income value with compare cell mean ratio
Compared with, progress statistical test, inspection result such as following table：
(* p ＜ 0.05 compared with the control group, * * p ＜ 0.01)
It selects through the qualified cavy 100, weight 180-200g of screening, is randomly divided into 5 groups, every group 10, half male and half female.
Dosage shown according to the form below, 1 time a day, for three days on end, control group gives same volume deionized water.In after the last administration
40 minutes, every animal is respectively placed in spraying device, a concentration of 0.2% histamine phosphate solution with lured to cough to draw and breathes heavily instrument at the uniform velocity
It sprays into 18 seconds, records cavy asthmatic latent period.By each group averaging of income value compared with compareing cell mean, statistics inspection is carried out
It tests, inspection result such as following table：
(* p ＜ 0.05 compared with the control group, * * p ＜ 0.01)
It can be seen that carrying out the production of 4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma using the method for the present invention, and it is respectively used to
It on mouse and cavy, can significantly extend mouse cough incubation period, reduce cough number, while can very significantly extend
The asthmatic latent period of cavy shows that 4 grams of obtained dress granules for curing infantile lung pathogenic heat and cough and asthma have apparent cough-relieving and antiasthmatic effect.
Claims (7)
1. a kind of preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma, weighs the Chinese medicine of following parts by weight：
It is characterised in that it includes following steps：
(1) it will add water to cook after described ten simply medicinal material mixing 2 times, decoct 1~4 hour every time, the dosage of first time water is medicine
The dosage of 8~12 times of amounts of material total weight, second of water is 6~10 times of amounts of medicinal material total weight, merges 2 obtained extractions
Liquid, filtrate is spare after filtering；
(2) obtained filtrate is concentrated into the clear cream that relative density is 1.06~1.19, will be measured after clear cream spraying drying powder-forming
Cane sugar powder is added according to the Chinese ephedra content measured in Chinese ephedra content, and particle is made in mixing；
(3) will after obtained particle drying by 4g/ bags dispense, control Chinese ephedra content be 1.80~1.90mg/ bag, be made described in
4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma.
2. the preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma according to claim 1, which is characterized in that including as follows
Step：
(1) it will add water to cook after described ten simply medicinal material mixing 2 times, decoct 1~3 hour every time, the dosage of first time water is medicine
The dosage of 9~11 times of amounts of material total weight, second of water is 7~9 times of amounts of medicinal material total weight, merges 2 obtained extracting solutions,
Filtrate is spare after filtering；
(2) obtained filtrate is concentrated into the clear cream that relative density is 1.10~1.17, will be measured after clear cream spraying drying powder-forming
Cane sugar powder is added according to the Chinese ephedra content measured in Chinese ephedra content, and particle is made in mixing；
(3) will after obtained particle drying by 4g/ bags dispense, control Chinese ephedra content be 1.85~1.90mg/ bag, be made described in
4 grams of dress granules for curing infantile lung pathogenic heat and cough and asthma.
3. the preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma according to claim 1, which is characterized in that the step
(2) filtrate in is concentrated in dual-effect energy-saving concentrator and carries out.
4. the preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma according to claim 3, which is characterized in that the filter
Liquid concentrates condition：Thickening temperature is 60~70 DEG C, and concentration vacuum degree is -0.06~-0.08MPa.
5. the preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma according to claim 1, which is characterized in that the step
(2) spray drying carries out in spray dryer in.
6. the preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma according to claim 5, which is characterized in that the spraying
Dry condition is：It is 60~75 DEG C to control clear cream temperature, and motor speed is 5~10HZ, and inlet air temperature is 140~160 DEG C, is gone out
Air temperature is 80~90 DEG C.
7. the preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma according to claim 1, which is characterized in that the step
(3) drying temperature when dry in is 75~85 DEG C, and drying time is 1~3 hour.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112472749A (en) * | 2020-12-18 | 2021-03-12 | 天津中新药业集团股份有限公司达仁堂制药厂 | Traditional Chinese medicine granules for treating chronic obstructive pulmonary disease in stationary phase and preparation method and application thereof |
| CN113384650A (en) * | 2021-06-15 | 2021-09-14 | 海南葫芦娃药业集团股份有限公司 | Preparation method of infantile lung-heat cough and asthma granules |
| CN113687005A (en) * | 2021-09-17 | 2021-11-23 | 海南葫芦娃药业集团股份有限公司 | Method for determining content of ephedrine hydrochloride and pseudoephedrine hydrochloride in infantile lung heat cough and asthma granules |
| CN113720957A (en) * | 2021-08-04 | 2021-11-30 | 海南葫芦娃药业集团股份有限公司 | Method for identifying effective components of houttuynia cordata in infantile lung heat cough and asthma granules |
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| CN1097320A (en) * | 1993-07-13 | 1995-01-18 | 四川省中药厂 | Sugarless type infantile lung heat instant powder for asthma and cough and preparation method thereof |
| CN101780214A (en) * | 2010-03-30 | 2010-07-21 | 海南新中正制药有限公司 | Method for preparing granules for curing infantile lung pathogenic heat and cough and asthma |
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| CN1097320A (en) * | 1993-07-13 | 1995-01-18 | 四川省中药厂 | Sugarless type infantile lung heat instant powder for asthma and cough and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112472749A (en) * | 2020-12-18 | 2021-03-12 | 天津中新药业集团股份有限公司达仁堂制药厂 | Traditional Chinese medicine granules for treating chronic obstructive pulmonary disease in stationary phase and preparation method and application thereof |
| CN113384650A (en) * | 2021-06-15 | 2021-09-14 | 海南葫芦娃药业集团股份有限公司 | Preparation method of infantile lung-heat cough and asthma granules |
| CN113720957A (en) * | 2021-08-04 | 2021-11-30 | 海南葫芦娃药业集团股份有限公司 | Method for identifying effective components of houttuynia cordata in infantile lung heat cough and asthma granules |
| CN113687005A (en) * | 2021-09-17 | 2021-11-23 | 海南葫芦娃药业集团股份有限公司 | Method for determining content of ephedrine hydrochloride and pseudoephedrine hydrochloride in infantile lung heat cough and asthma granules |
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Application publication date: 20180921 |