CN101780214A - Method for preparing granules for curing infantile lung pathogenic heat and cough and asthma - Google Patents
Method for preparing granules for curing infantile lung pathogenic heat and cough and asthma Download PDFInfo
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- CN101780214A CN101780214A CN 201010134951 CN201010134951A CN101780214A CN 101780214 A CN101780214 A CN 101780214A CN 201010134951 CN201010134951 CN 201010134951 CN 201010134951 A CN201010134951 A CN 201010134951A CN 101780214 A CN101780214 A CN 101780214A
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- 238000000034 method Methods 0.000 title abstract description 16
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a method for preparing granules for curing infantile lung pathogenic heat and cough and asthma. The method comprises the following steps: weighing the following Chinese medicinal materials in part by weight: 30 parts of ephedra, 60 parts of bitter almond kernel, 240 parts of raw gypsum, 30 parts of liquorice root, 100 parts of honeysuckle, 100 parts of weeping forsythiae capsule, 100 parts of anemarrhena root, 100 parts of baikal skullcap root, 100 parts of indigowoad root, 100 parts of dwarf lilyturf tuber and 100 parts of cordate houttuynia; dividing the eleven Chinese medicinal materials into two groups; after performing water extraction on the two groups of Chinese medicinal materials, combining filtrates; mixing an extract prepared by concentrating the filtrate with a proper amount of dextrine and sodium cyclamate; preparing the mixture into granules; and drying the granules to obtain the granules for curing the infantile lung pathogenic heat and cough and asthma. In the method, water use amount in the process of performing water extraction on the Chinese medicinal materials is strictly controlled and extraction in different groups is carried out according to characteristics of different medicinal materials, so compared with a traditional water extraction method, the method has a better effect. The prepared granules for curing the infantile lung pathogenic heat and cough and asthma have stable and controllable quality, and stable baicalin distinguish project which meets requirements of standard. The method greatly improves qualification rate of the product, and has simple operation and is suitable for industrial production.
Description
Technical field
The present invention relates to the preparation of pharmaceutical formulations field, be specifically related to a kind of preparation method of granules for curing infantile lung pathogenic heat and cough and asthma.
Background technology
Existing infantile lung heat cough with asthma preparation generally with Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, Fructus Forsythiae, the Rhizoma Anemarrhenae, Radix Scutellariae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae ten simply Chinese crude drug be that raw material is made, effect with heat-clearing and toxic substances removing, lung qi dispersing cough-relieving, resolving phlegm and relieving asthma, clinical practice proves that it belongs to phlegm-heat obstructing in the lung disease person for flu, bronchitis, asthmatic bronchitis, bronchopneumonia and has the curative effect of highly significant.
Infantile lung heat cough with asthma preparation mostly is the infantile lung heat instant powder for asthma and cough quality standard (WS that records according to the 18 the 14th page in the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation
3-B-3361-98) preparation granule.
The method for making of traditional granules for curing infantile lung pathogenic heat and cough and asthma is: take by weighing the 30g Herba Ephedrae by recipe quantity, the 60g Semen Armeniacae Amarum, the 240g Gypsum Fibrosum, the 30g Radix Glycyrrhizae, the 100g Flos Lonicerae, the 100g Fructus Forsythiae, the 100g Rhizoma Anemarrhenae, the 100g Radix Scutellariae, the 100g Radix Isatidis, 100g Radix Ophiopogonis and 100g Herba Houttuyniae ten be Chinese crude drug simply, decoct with water 2 times, each 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste of 60～70 ℃ of relative densities 1.17, press clear paste 1 weight portion, the proportioning of dextrin 0.27 weight portion and sodium cyclamate 0.05 weight portion is made granule after mixing, sieve, packing promptly gets granules for curing infantile lung pathogenic heat and cough and asthma.
Above-mentioned clear paste is the water extraction product, the granules for curing infantile lung pathogenic heat and cough and asthma of making is differentiated item owing to contain baicalin in the target level of product quality, and baicalin water insoluble (alkali condition is dissolving down), by prior art production, baicalin can not fully be extracted, cause a baicalin discriminating instability in the product, cause quality of the pharmaceutical preparations instability, product percent of pass is on the low side.
Summary of the invention
The invention provides a kind of easy and simple to handle, quality controllable and be suitable for the preparation method of the granules for curing infantile lung pathogenic heat and cough and asthma of suitability for industrialized production; fundamentally avoid the granules for curing infantile lung pathogenic heat and cough and asthma baicalin of existing preparation method preparation to differentiate a underproof phenomenon, improved the qualification rate of product greatly.
A kind of preparation method of granules for curing infantile lung pathogenic heat and cough and asthma takes by weighing following parts by weight of Chinese traditional medicine material:
Herba Ephedrae 30 Semen Armeniacae Amarums 60 Gypsum Fibrosum 240 Radix Glycyrrhizaes 30
Flos Lonicerae 100 Fructus Forsythiaes 100 Rhizoma Anemarrhenaes 100 Radix Scutellariaes 100
Radix Isatidis Herba Houttuyniae 100 100 Radix Ophiopogonis 100;
Preparation according to the following steps:
(1) take by weighing Radix Scutellariae and Herba Ephedrae two flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 3～8 times of amounts of two flavor medical material gross weights, merges 2 times extracting solution, and it is standby to filter rear filtrate;
(2) take by weighing Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, the Rhizoma Anemarrhenae, Fructus Forsythiae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae nine flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 3～8 times of amounts of nine flavor medical material gross weights, merge 2 times extracting solution, it is standby to filter rear filtrate;
(3) filtrate in combining step (1) and the step (2), be concentrated into 60～70 ℃ of relative densities and be 1.17 clear paste, proportioning by clear paste 1 weight portion, dextrin 0.27 weight portion and sodium cyclamate 0.05 weight portion is made granule, sieves, and promptly makes granules for curing infantile lung pathogenic heat and cough and asthma.
In order to make the granules for curing infantile lung pathogenic heat and cough and asthma baicalin differentiate that item is more stable, preferably prepare according to the following steps:
(1) take by weighing Radix Scutellariae and Herba Ephedrae two flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 5 times of amounts of two flavor medical material gross weights, merges 2 times extracting solution, and it is standby to filter rear filtrate;
(2) take by weighing Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, the Rhizoma Anemarrhenae, Fructus Forsythiae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae nine flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 5 times of amounts of nine flavor medical material gross weights, merge 2 times extracting solution, it is standby to filter rear filtrate;
(3) filtrate in combining step (1) and the step (2), be concentrated into 60～70 ℃ of relative densities and be 1.17 clear paste, make granule behind the proportioning mixing by clear paste 1 weight portion, dextrin 0.27 weight portion and sodium cyclamate 0.05 weight portion, sieve, promptly make granules for curing infantile lung pathogenic heat and cough and asthma.
Baicalin is under general condition water insoluble, but soluble in water under alkaline environment, and the main component of Herba Ephedrae is ephedrine, pseudoephedrine and ephedine etc., and its decocting liquid is alkalescence, in advance Herba Ephedrae and Radix Scutellariae is merged decoction, the effective ingredient stripping of can mutually promoting; And in the existing method with ten simply medical material decoct simultaneously, it is neutral that decocting liquid is, and is unfavorable for the stripping of baicalin, it is defective very easily to cause in the final products baicalin to be differentiated.
The pharmacological action baicalin (Baicalin) of baicalin is a kind of flavone compound that extraction separation comes out from scutellariae,radix, has significant biological activity, have antibacterial, diuresis, antiinflammatory, resistance attitude and spasmolysis, and have stronger physiological potencies such as antitumor response.Occupied critical role at clinical medicine.Baicalin can also absorb ultraviolet, removes oxygen-derived free radicals, can suppress melanic generation again, therefore both can be used for medicine, also can be used for cosmetics, is a kind of good functional cosmetics raw material.Function cures mainly: the removing the relative excess fire, and except that damp and hot, hemostasis, antiabortive.Control the high fever excessive thirst, the cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria is told, is defeated in battle, collapses, is leaked, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.
Baicalin has very important drug effect in this product granules for curing infantile lung pathogenic heat and cough and asthma, so classify it as discriminating item in the quality standard of granules for curing infantile lung pathogenic heat and cough and asthma.
This product specification is every packed 3g; Usage and consumption are: boiled water is taken after mixing it with water, and three one full year of life are with 3g next time, 3 times on the one; Three one full year of life are with last 3g, 4 times on the one; Seven one full year of life are with last 6g, 3 times on the one.
Crude drug of the present invention specifically describes as follows:
Herba Ephedrae is the dry herb stem of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf, epheday intermedia Ephedraintermedia Schrenk et C.A.Mey. or ephedra equisetina Ephedra equisetina Bge..Tap green herb stem autumn, dry.Ephedra sinica is elongated cylindrical, few branch; Diameter 1～2mm.The a small amount of brown woody stems of the band that has.The surface light green has thin longitudinal ridge line to yellow green, and that touches littlely has a harsh feeling.Joint is obvious, the long 2～6cm of internode.Membranous scale leaf is arranged, long 3～4mm on the joint; Sliver 2 (rare 3), sharp triangle, the tip canescence, contrary flexure, base portion is unified into tubular, rufous.Body is light, and matter is crisp, frangibility, and section slightly is fibroid, peripheral green-yellow, marrow rufous, subcircular.Feeble QI perfume (or spice), puckery, little hardship.The epheday intermedia multi-branched, diameter 1.5～3mm has harsh feeling.Long 2～the 6cm of internode, the long 2～3mm of membranous scale leaf, sliver 3 (rare 2), the sharp point of tip.The section marrow is the triangular shape circle.Ephedra equisetina is than multi-branched, diameter 1～1.5mm, no harsh feeling.Long 1.5～the 3cm of internode.Long 1～the 2mm of membranous scale leaf; Sliver 2 (rare 3), top is short triangle, canescence, how not contrary flexure of tip, the base portion brownish red is to brownish black.
Semen Armeniacae Amarum is the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. Prunus armeniaca L.var.ansuMaxim., Siberia Fructus Pruni Prunus sibirica L., prunus mandshuricaKoehne Prunusmandshurica (Maxim.) Koehne or Fructus Pruni Prunus armeniaca L..The mature fruit of gathering summer is removed sarcocarp and nucleocapsid, takes out seed, dries.This product is flat heart, long 1～1.9cm, wide 0.8～1.5cm, thick 0.5～0.8cm.The surface yellowish-brown to dark-brown, an end point, other holds blunt circle, plumpness, the left and right sides is asymmetric.A most advanced and sophisticated side has short-term shape hilum, the nose circle chalaza place most dark-brown veins of tool that make progress.It is thin to plant skin, cotyledon 2, milky, rich oil.Odorless, bitter in the mouth.
Gypsum Fibrosum refers to natural dihydrate gypsum (containing two hydrones), main chemical compositions: CaSO4nH2O.Be fibrous agrregate, be long block, plate-like or irregular bulk.White, canescence or faint yellow, what have is translucent.Body weight, matter is soft, vertical section tool spun silk sample gloss, feeble QI, lightly seasoned.: (heat clearing and fire purging medicine) is hot, sweet, is slightly cold; Attach to the lung and stomach meridians.
Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhizainflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Spring, Qiu Erji excavate, and remove fibrous root, dry.Root is cylindrical, long 25～100cm, diameter 0.6～3.5cm.The crust degree of tightness differs.The vertical significantly wrinkle of the brown or taupe brown of surface red, tool, rill, hole skin and sparse radicula trace.Matter is solid, and section shows slightly fibroid, yellow-white, and mealiness, cambium ring is obvious, the ray irradiation shape, what have has a crack.Rhizome is cylindrical, and there is the bud trace on the surface, and there is marrow at the section middle part.Feeble QI, it is sweet and special to distinguish the flavor of.
Flos Lonicerae is the dry flower of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicerahypoglau-ca Miq., Flos Lonicerae Lonicera confusa DC. or hair style Radix Ophiopogonis Loniceradasystyla Rehd. or the flower that band is just opened.The flowers are in blossom gathers drying before putting for early summer.Appearance yellow or yellowish-brown are had pubescence and glandular hair, base portion that green tiny calyx is arranged, and 5 split, and the sliver triangle does not have hair.Cut alabastrum open and then see 5 pieces of stamens and 1 piece of gynoecium.Corolla lip, female stamen are and must stretch out by shape.Radix Ophiopogonis is bar-shaped, and is upper coarse and lower fine, slightly crooked, long 2～3cm, the about 3mm of upper diameter, the about 1.5mm of lower diameter.Surface yellow-white or green white (it is gradually dark to store color of a specified duration), close by pubescence.Accidental lobate bract.The calyx green, tip 5 splits, and the sliver hairiness is about 2mm.Opening person's corolla tubular, tip two lips; 5 on stamen invests barrel, yellow; 1 of gynoecium, ovary does not have hair.Gas delicate fragrance, lightly seasoned, little hardship.Long 2.5～the 4.5cm of Flos Lonicerae, diameter 0.8～2mm.The surface HUANGBAI(sic) does not have hair or dredges the quilt hair to yellowish-brown.Calyx tube does not have hair, and tip 5 splits, and sliver Yangtze River Delta shape is by hair.The counter-rotating of opening person's corolla lower lip.Style does not have hair.Long 1.6～the 3.5cm of Flos Lonicerae, diameter 0.5～2mm.Calyx tube and corolla are close by the canescence hair, the ovary hairiness.Hair style long 2.5～4cm of Radix Ophiopogonis, diameter 1～2.5mm.The faint yellow little band purple in surface does not have hair.The short triangle of calyx lobes.Opening person's upper lip of corolla is often irregular, style bottom Duo Mi villosity.
Fructus Forsythiae is the dry fruit of Oleaceae plant Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.Gather during the just ripe band still of fruit in autumn green, remove impurity, cook, dry, practise title " green grass or young crops sticks up "; Gather when fruit is well-done, dry, remove impurity, practise title " sticking up always ".It is long avette to avette, flat slightly that this product is, long 1.5～2.5cm, diameter 0.5～1.3cm.There is the fleck of irregular vertical wrinkle and most projectioies on the surface, and respectively there is 1 tangible longitudinal furrow on the two sides.Top tax point, base portion have little carpopodium or have come off." green grass or young crops sticks up " is many does not ftracture, surperficial green and brown color, and the canescence fleck of projection is less; Matter is hard; The seed majority, yellow green, elongated, a side has wing." stick up " from top cracking always or be cleaved into two lobes, surperficial yellowish-brown or rufous, inner surface mostly is light yellowish brown, and is level and smooth, tool one mediastinum; Matter is crisp; Seed is brown, how to come off.Feeble QI perfume (or spice), bitter in the mouth.
The Rhizoma Anemarrhenae is the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bge..Spring, Qiu Erji excavate, and remove fibrous root and silt, dry, and practise claiming " RHIZOMA ANEMARRHENAE with peet "; Or remove crust, dry.This product is strip, and microbend is slightly flat, and idol has branch, long 3～15cm, and diameter 0.8～1.5cm, an end have the residual trace of lurid stem and leaf.The surface yellowish-brown has a chase above to brown, the compact arranged ring joint of tool, and the brown remaining phyllopodium of close SHENGHUANG on the joint is by the growth of two side direction rhizomes top; Swell and slightly shrinkage below, and the point-like root trace of depressions or protrusions is arranged.Matter is hard, frangibility, section yellow-white.Feeble QI, it is little sweet, slightly bitter to distinguish the flavor of, the band viscosity of chewing.
Radix Scutellariae is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Spring, Qiu Erji excavate, and remove fibrous root and silt, hit rough bark after the solarization, dry.It is conical that this product is, distortion, long 8～25cm, diameter 1～3cm.Pale brown color in surface or buff have sparse excipuliform radicula trace, and top is more coarse, and the vertical wrinkle or the irregular reticulate pattern of distortion arranged, and rift grain and scabriculous are arranged at the bottom.Matter is hard and crisp, frangibility, section yellow, middle rufous; Dry and decayed shape in old root center or hollow are burgundy or brownish black.Feeble QI, bitter in the mouth.
Radix Isatidis is the dry root of cruciferae isatis Isatis indigotica Fort..Excavate autumn, removes silt, dries.Cylindrical, distortion slightly, long 10-20cm diameter 0.5-1cm, surperficial light lark or light brown yellow have vertical wrinkle grow crosswise hole skin sample projection and taproot trace, and the root head slightly expands, and body is real, and matter is slightly soft, section skin zone yellow-white, woody part yellow, feeble QI, little sweet back bitterness of distinguishing the flavor of.
Be the dried root of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl. Radix Ophiopogonis.Excavate summer, cleans, and is exposed to the sun repeatedly, banks up, and to doing very likely, removes fibrous root, drying.This product is spindle, and two ends are point slightly, long 1.5～3cm, diameter 0.3～0.6cm.Surface yellow-white or light yellowish-white has thin longitudinal grin.Matter is pliable and tough, the section yellow-white, and translucent, center pillar is tiny.Feeble QI perfume (or spice), sweet in the mouth, little hardship.
Herba Houttuyniae is the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..The luxuriant spica of stem and leaf in summer is tapped for a long time, removes impurity, dries.The stem oblateness, shrinkage and bending, long 20-30cm; The surface yellowish-brown, tool is indulged rib, and joint is obvious, and joint place in bottom has fibrous root remaining; Matter is crisp, frangibility.The leaf alternate.Many shrinkages.It is heart-shaped to flatten the back, long 3-5, wide 3-4.5cm; Above dark green or yellow green, below green and brown color or taupe brown; Petiole is elongated, and base portion and stipule synthesize the sheath shape.Spike Xiang Sheng.Rub broken bearing the odor of fish with the hands, it is little puckery to distinguish the flavor of.Many with leaf, color is green, spica is arranged, fishy smell.
In the inventive method the water consumption in the water extraction medical material process is carried out strict control, and carry out extract respectively according to different character of medicinal material, more traditional water extraction method is effective, the granules for curing infantile lung pathogenic heat and cough and asthma steady quality of preparation, controlled, a baicalin discriminating stable and conformance with standard requirement, improved the qualification rate of product greatly, and method is simple to operate, with short production cycle, need not special equipment, and cost is low, yield is high, is suitable for suitability for industrialized production.
The specific embodiment
Embodiment 1
Take by weighing the Chinese crude drug of following weight:
Herba Ephedrae 30g Semen Armeniacae Amarum 60g Gypsum Fibrosum 240g Radix Glycyrrhizae 30g
Flos Lonicerae 100g Fructus Forsythiae 100g Rhizoma Anemarrhenae 100g Radix Scutellariae 100g
Radix Isatidis 100g 100g Radix Ophiopogonis Herba Houttuyniae 100g;
Preparation according to the following steps:
(1) take by weighing Radix Scutellariae and Herba Ephedrae two flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 5 times of amounts of two flavor medical material gross weights, merges 2 times extracting solution, and it is standby to filter rear filtrate;
(2) take by weighing Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, the Rhizoma Anemarrhenae, Fructus Forsythiae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae nine flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 5 times of amounts of nine flavor medical material gross weights, merge 2 times extracting solution, it is standby to filter rear filtrate;
(3) filtrate in combining step (1) and the step (2), be concentrated into 60 ℃ of relative densities and be 1.17 clear paste, be to make granule behind 1: 0.27: 0.05 the proportioning mixing with clear paste, dextrin and sodium cyclamate by the weight ratio of clear paste, dextrin, sodium cyclamate, sieve, press the packing of 3g/ bag, promptly make 103 bags, granules for curing infantile lung pathogenic heat and cough and asthma.
Embodiment 2
Take by weighing the Chinese crude drug of following weight:
Herba Ephedrae 30g Semen Armeniacae Amarum 60g Gypsum Fibrosum 240g Radix Glycyrrhizae 30g
Flos Lonicerae 100g Fructus Forsythiae 100g Rhizoma Anemarrhenae 100g Radix Scutellariae 100g
Radix Isatidis 100g 100g Radix Ophiopogonis Herba Houttuyniae 100g;
Preparation according to the following steps:
(1) take by weighing Fructus Forsythiae and Herba Ephedrae two flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 3 times of amounts of two flavor medical material gross weights, merges 2 times extracting solution, and it is standby to filter rear filtrate;
(2) take by weighing Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, the Rhizoma Anemarrhenae, Radix Scutellariae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae nine flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 8 times of amounts of nine flavor medical material gross weights, merge 2 times extracting solution, it is standby to filter rear filtrate;
(3) filtrate in combining step (1) and the step (2), be concentrated into 60 ℃ of relative densities and be 1.17 clear paste, be to make granule behind 1: 0.27: 0.05 the proportioning mixing with clear paste, dextrin and sodium cyclamate by the weight ratio of clear paste, dextrin, sodium cyclamate, sieve, press the packing of 3g/ bag, promptly make 86 bags.Granules for curing infantile lung pathogenic heat and cough and asthma.
Embodiment 3
Take by weighing the Chinese crude drug of following weight:
Herba Ephedrae 30g Semen Armeniacae Amarum 60g Gypsum Fibrosum 240g Radix Glycyrrhizae 30g
Flos Lonicerae 100g Fructus Forsythiae 100g Rhizoma Anemarrhenae 100g Radix Scutellariae 100g
Radix Isatidis 100g 100g Radix Ophiopogonis Herba Houttuyniae 100g;
Preparation according to the following steps:
(1) take by weighing Fructus Forsythiae and Herba Ephedrae two flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 8 times of amounts of two flavor medical material gross weights, merges 2 times extracting solution, and it is standby to filter rear filtrate;
(2) take by weighing Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, the Rhizoma Anemarrhenae, Radix Scutellariae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae nine flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 3 times of amounts of nine flavor medical material gross weights, merge 2 times extracting solution, it is standby to filter rear filtrate;
(3) filtrate in combining step (1) and the step (2), be concentrated into 60 ℃ of relative densities and be 1.17 clear paste, be to make granule behind 1: 0.27: 0.05 the proportioning mixing with clear paste, dextrin and sodium cyclamate by the weight ratio of clear paste, dextrin, sodium cyclamate, sieve, press the packing of 3g/ bag, promptly make 116 bags.Granules for curing infantile lung pathogenic heat and cough and asthma.
Embodiment 4
Take by weighing the Chinese crude drug of following weight:
Herba Ephedrae 30g Semen Armeniacae Amarum 60g Gypsum Fibrosum 240g Radix Glycyrrhizae 30g
Flos Lonicerae 100g Fructus Forsythiae 100g Rhizoma Anemarrhenae 100g Radix Scutellariae 100g
Radix Isatidis 100g 100g Radix Ophiopogonis Herba Houttuyniae 100g;
Preparation according to the following steps:
(1) take by weighing Fructus Forsythiae and Herba Ephedrae two flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 4 times of amounts of two flavor medical material gross weights, merges 2 times extracting solution, and it is standby to filter rear filtrate;
(2) take by weighing Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, the Rhizoma Anemarrhenae, Radix Scutellariae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae nine flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 6 times of amounts of nine flavor medical material gross weights, merge 2 times extracting solution, it is standby to filter rear filtrate;
(3) filtrate in combining step (1) and the step (2), be concentrated into 60 ℃ of relative densities and be 1.17 clear paste, be to make granule behind 1: 0.27: 0.05 the proportioning mixing with clear paste, dextrin and sodium cyclamate by the weight ratio of clear paste, dextrin, sodium cyclamate, sieve, press the packing of 3g/ bag, promptly make 105 bags.Granules for curing infantile lung pathogenic heat and cough and asthma.
Embodiment 5
Take by weighing the Chinese crude drug of following weight:
Herba Ephedrae 30g Semen Armeniacae Amarum 60g Gypsum Fibrosum 240g Radix Glycyrrhizae 30g
Flos Lonicerae 100g Fructus Forsythiae 100g Rhizoma Anemarrhenae 100g Radix Scutellariae 100g
Radix Isatidis 100g 100g Radix Ophiopogonis Herba Houttuyniae 100g;
Preparation according to the following steps:
(1) take by weighing Fructus Forsythiae and Herba Ephedrae two flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 7 times of amounts of two flavor medical material gross weights, merges 2 times extracting solution, and it is standby to filter rear filtrate;
(2) take by weighing Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, the Rhizoma Anemarrhenae, Radix Scutellariae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae nine flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 5 times of amounts of nine flavor medical material gross weights, merge 2 times extracting solution, it is standby to filter rear filtrate;
(3) filtrate in combining step (1) and the step (2), be concentrated into 60 ℃ of relative densities and be 1.17 clear paste, be to make granule behind 1: 0.27: 0.05 the proportioning mixing with clear paste, dextrin and sodium cyclamate by the weight ratio of clear paste, dextrin, sodium cyclamate, sieve, press the packing of 3g/ bag, promptly make 110 bags.Granules for curing infantile lung pathogenic heat and cough and asthma.
Comparative Examples 1
Take by weighing the Chinese crude drug of following weight:
Herba Ephedrae 30g Semen Armeniacae Amarum 60g Gypsum Fibrosum 240g Radix Glycyrrhizae 30g
Flos Lonicerae 100g Fructus Forsythiae 100g Rhizoma Anemarrhenae 100g Radix Scutellariae 100g
Radix Isatidis 100g 100g Radix Ophiopogonis Herba Houttuyniae 100g;
Preparation according to the following steps:
Take by weighing Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, Fructus Forsythiae, the Rhizoma Anemarrhenae, Radix Scutellariae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae ten medical material simply, decoct with water 2 times, each 1 hour, the consumption of each water is 19 times of amounts of medical material gross weight simply, merge 2 times extracting solution, filtering rear filtrate, to be concentrated into 60 ℃ of relative densities be 1.17 clear paste, be to make granule behind 1: 0.27: 0.05 the proportioning mixing with clear paste, dextrin and sodium cyclamate by the weight ratio of clear paste, dextrin, sodium cyclamate, sieve, press the packing of 3g/ bag, promptly make 116 bags.Granules for curing infantile lung pathogenic heat and cough and asthma.
Comparative Examples 2
Except adopting ten simply the water of 5 times of amounts of medical material gross weight, all the other are operated all with Comparative Examples 1, make 98 bags.Granules for curing infantile lung pathogenic heat and cough and asthma.
Comparative Examples 3
Except adopting ten simply the water of 8 times of amounts of medical material gross weight, all the other are operated all with Comparative Examples 1, make 108 bags.Granules for curing infantile lung pathogenic heat and cough and asthma.
Comparative Examples 4
Except adopting ten simply the water of 10 times of amounts of medical material gross weight, all the other are operated all with Comparative Examples 1, make 118 bags.Granules for curing infantile lung pathogenic heat and cough and asthma.
Comparative Examples 5
Except adopting ten simply the water of 3 times of amounts of medical material gross weight, all the other are operated all with Comparative Examples 1, make 82 bags.Granules for curing infantile lung pathogenic heat and cough and asthma.
The infantile lung heat instant powder for asthma and cough quality standard (WS that records according to the 6th the 14th page in the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation
3The granules for curing infantile lung pathogenic heat and cough and asthma that-method in B-3361-98) makes the foregoing description 1～5 and Comparative Examples 1～5 carries out baicalin and differentiates.
Other index under the granule item, all carry out every index and detect assay such as following table according to the detection method of an appendix I of 2000 editions Pharmacopoeias of People's Republic of China C granule:
| Baicalin is differentiated a testing result | Other index under the granule item | Conclusion | |
| Embodiment 1 | Qualified | Qualified | Qualified |
| Embodiment 2 | Qualified | Qualified | Qualified |
| Embodiment 3 | Qualified | Qualified | Qualified |
| Embodiment 4 | Qualified | Qualified | Qualified |
| Embodiment 5 | Qualified | Qualified | Qualified |
| Comparative Examples 1 | Qualified | Qualified | Qualified |
| Comparative Examples 2 | Defective | Defective | Defective |
| Comparative Examples 3 | Defective | Defective | Defective |
| Comparative Examples 4 | Qualified | Qualified | Qualified |
| Comparative Examples 5 | Defective | Defective | Defective |
This shows that adopt the inventive method to carry out granules for curing infantile lung pathogenic heat and cough and asthma production, baicalin differentiates that item is all qualified in the finished product, steady quality, controlled is better than existing preparation method.
Claims (2)
1. the preparation method of a granules for curing infantile lung pathogenic heat and cough and asthma is characterized in that, takes by weighing following parts by weight of Chinese traditional medicine material:
Herba Ephedrae 30 Semen Armeniacae Amarums 60 Gypsum Fibrosum 240 Radix Glycyrrhizaes 30
Flos Lonicerae 100 Fructus Forsythiaes 100 Rhizoma Anemarrhenaes 100 Radix Scutellariaes 100
Radix Isatidis Herba Houttuyniae 100 100 Radix Ophiopogonis 100;
Preparation according to the following steps:
(1) take by weighing Radix Scutellariae and Herba Ephedrae two flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 3～8 times of amounts of two flavor medical material gross weights, merges 2 times extracting solution, and it is standby to filter rear filtrate;
(2) take by weighing Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, the Rhizoma Anemarrhenae, Fructus Forsythiae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae nine flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 3～8 times of amounts of nine flavor medical material gross weights, merge 2 times extracting solution, it is standby to filter rear filtrate;
(3) filtrate in combining step (1) and the step (2), be concentrated into 60～70 ℃ of relative densities and be 1.17 clear paste, proportioning by clear paste 1 weight portion, dextrin 0.27 weight portion and sodium cyclamate 0.05 weight portion is made granule, sieves, and promptly makes granules for curing infantile lung pathogenic heat and cough and asthma.
2. preparation method as claimed in claim 1 is characterized in that, according to the following steps preparation:
(1) take by weighing Radix Scutellariae and Herba Ephedrae two flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 5 times of amounts of two flavor medical material gross weights, merges 2 times extracting solution, and it is standby to filter rear filtrate;
(2) take by weighing Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, the Rhizoma Anemarrhenae, Fructus Forsythiae, Radix Isatidis, Radix Ophiopogonis and Herba Houttuyniae nine flavor medical materials, decoct with water behind the mixing 2 times, each 1 hour, the consumption of each water was 5 times of amounts of nine flavor medical material gross weights, merge 2 times extracting solution, it is standby to filter rear filtrate;
(3) filtrate in combining step (1) and the step (2), be concentrated into 60～70 ℃ of relative densities and be 1.17 clear paste, make granule behind the proportioning mixing by clear paste 1 weight portion, dextrin 0.27 weight portion and sodium cyclamate 0.05 weight portion, sieve, promptly make granules for curing infantile lung pathogenic heat and cough and asthma.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293912A (en) * | 2011-09-28 | 2011-12-28 | 曹文真 | Chinese medicine for treating pneumonia |
| CN102716400A (en) * | 2012-07-02 | 2012-10-10 | 罗碧 | Lung-heat clearing and cough relieving soup for babies |
| CN103611024A (en) * | 2013-12-06 | 2014-03-05 | 杨云 | Traditional Chinese medicine for treating pneumonia |
| CN103656601A (en) * | 2013-12-23 | 2014-03-26 | 青岛安信医疗器械有限公司 | Traditional Chinese medicinal decoction for treating bacterial pneumonia |
| CN105998984A (en) * | 2016-08-01 | 2016-10-12 | 毛德西 | Traditional Chinese medicine for treating children with lung heat type cough and asthma |
| CN108553578A (en) * | 2018-05-30 | 2018-09-21 | 海南葫芦娃药业集团股份有限公司 | A kind of preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537056A (en) * | 2008-03-19 | 2009-09-23 | 北京亚东生物制药有限公司 | Method for preparing Chinese medicinal preparation for treating external respiration infection of children |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101537056A (en) * | 2008-03-19 | 2009-09-23 | 北京亚东生物制药有限公司 | Method for preparing Chinese medicinal preparation for treating external respiration infection of children |
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| 《江西中医药》 19861231 陈连如，孙红英等 中药咳喘合剂剂型研究 第41-42页 1-2 , 第5期 2 * |
| 《湖南中医药导报》 20030430 熊艳，吴学文，蒋孟良 汤剂的分煎与混煎对成分及药效的影响 第80-84页 1-2 第9卷, 第4期 2 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293912A (en) * | 2011-09-28 | 2011-12-28 | 曹文真 | Chinese medicine for treating pneumonia |
| CN102293912B (en) * | 2011-09-28 | 2013-04-24 | 曹文真 | Chinese medicine for treating pneumonia |
| CN102716400A (en) * | 2012-07-02 | 2012-10-10 | 罗碧 | Lung-heat clearing and cough relieving soup for babies |
| CN102716400B (en) * | 2012-07-02 | 2014-11-05 | 罗碧 | Lung-heat clearing and cough relieving soup for babies |
| CN103611024A (en) * | 2013-12-06 | 2014-03-05 | 杨云 | Traditional Chinese medicine for treating pneumonia |
| CN103656601A (en) * | 2013-12-23 | 2014-03-26 | 青岛安信医疗器械有限公司 | Traditional Chinese medicinal decoction for treating bacterial pneumonia |
| CN105998984A (en) * | 2016-08-01 | 2016-10-12 | 毛德西 | Traditional Chinese medicine for treating children with lung heat type cough and asthma |
| CN108553578A (en) * | 2018-05-30 | 2018-09-21 | 海南葫芦娃药业集团股份有限公司 | A kind of preparation method of 4 grams of dresses granules for curing infantile lung pathogenic heat and cough and asthma |
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| CN101780214B (en) | 2012-02-01 |
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