KR20120041841A - Herbal composition for acne treatment and skin enhancement - Google Patents

Herbal composition for acne treatment and skin enhancement Download PDF

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KR20120041841A
KR20120041841A KR1020100103196A KR20100103196A KR20120041841A KR 20120041841 A KR20120041841 A KR 20120041841A KR 1020100103196 A KR1020100103196 A KR 1020100103196A KR 20100103196 A KR20100103196 A KR 20100103196A KR 20120041841 A KR20120041841 A KR 20120041841A
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acne
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강홍구
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강홍구
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)

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Abstract

PURPOSE: A composition containing oriental medicinal herb extract is provided to treat acne and to improve skin condition. CONSTITUTION: An oriental medicinal herb extract for treating acne and improving skin condition contains 7-8 parts by weight of Phaseoli radiati Semen, 7-8 parts by weight of Angelicae dahuricae Radix, 7-8 parts by weight of Bletillae Rhizoma, 7-8 parts by weight of Bombycis Corpus, 7-8 parts by weight of Aconitum koreanum, 7-8 parts by weight of Trichosanthes kirillowii Maxim, 3-4 parts by weight of Nardostachys jatamansi, 3-4 parts by weight of Kaempferia galangal, 3-4 parts by weight of Agastachis herba, and 0.7-0.8 parts by weight of Gleditsiae Spina.

Description

여드름 치료 및 피부상태 개선용 한약조성물{HERBAL COMPOSITION FOR ACNE TREATMENT AND SKIN ENHANCEMENT}Herbal composition for acne treatment and skin condition improvement {HERBAL COMPOSITION FOR ACNE TREATMENT AND SKIN ENHANCEMENT}

본 발명은 여드름 치료 및 피부상태 개선용 한약추출물에 관한 것으로 상세하게는 기미, 주근깨, 여드름 등의 증상을 우수하게 개선시킬 수 있는 한약추출물에 관한 것이다.The present invention relates to herbal extracts for treating acne and improving skin conditions, and more particularly, to herbal extracts that can improve symptoms such as blemishes, freckles, and acne.

최근 우리나라는 산업발달과 생활수준의 향상, 각종 문화시설의 도입으로 인해 장시간 오염된 환경에 노출되고, 과도한 스트레스로 인하여 피부질환이 증가하는 추세다. Recently, Korea has been exposed to polluted environment for a long time due to industrial development, improvement of living standards and introduction of various cultural facilities, and skin disease is increasing due to excessive stress.

그럼에도 불구하고 피부질환 특히 여드름에 효과가 우수한 한약추출물은 거의 없는 실정이다.Nevertheless, there are few herbal extracts with excellent effects on skin diseases, especially acne.

본 발명의 목적은 여드름 치료 및 피부상태 개선에 우수한 한약추출물을 제공하는데 있다.It is an object of the present invention to provide an herbal extract excellent in treating acne and improving skin condition.

상기 목적을 달성하기 위하여 본 발명에 따른 여드름 치료 및 피부상태 개선용 한약추출물은 녹두 7 내지 8 중량부, 백지 7 내지 8 중량부, 백급 7 내지 8 중량부, 백렴 7 내지 8 중량부, 백강잠 7 내지 8 중량부, 백부자 7 내지 8 중량부, 천화분 7 내지 8 중량부, 감송향 3 내지 4 중량부, 삼내자 3 내지 4 중량부, 곽향 3 내지 4 중량부, 영릉향 1.4 내지 1.6 중량부, 방풍 1.4 내지 1.6 중량부, 고본 1.4 내지 1.6 중량부, 조각자 0.7 내지 0.8 중량부와 80% 알콜 700㎖ 내지 800㎖를 포함하여 이루어지는 것을 특징으로 한다.Herbal extract for acne treatment and skin condition improvement according to the present invention in order to achieve the above object is 7 to 8 parts by weight, 7 to 8 parts by weight of white paper, 7 to 8 parts by weight, 7 to 8 parts by weight of baekryeom, Baekjap 7 To 8 parts by weight, white ton 7 to 8 parts by weight, 7 to 8 parts by weight of cheonhwa, 3 to 4 parts by weight of persimmon, 3 to 4 parts by weight, 3 to 4 parts by weight, Yeokneung to 1.4 to 1.6 parts by weight, Windproof 1.4 to 1.6 parts by weight, the original 1.4 to 1.6 parts by weight, carved 0.7 to 0.8 parts by weight and 80% alcohol, characterized in that it comprises 700 to 800 ml.

본 발명에 의하면, 본 발명의 한약추출물은 액체상태로 제조하여 피부에 도포함으로써 여드름의 치료 및 피부상태를 개선할 수 있다.According to the present invention, the herbal extract of the present invention can be prepared in a liquid state and applied to the skin to improve acne treatment and skin condition.

본 발명에 여드름 치료 및 피부상태 개선용 한약추출물을 이루는 성분들에 대하여 설명한다.The components of the herbal extract for acne treatment and skin condition improvement are described in the present invention.

상기 녹두(綠豆)는 쌍떡잎식물 장미목, 콩과의 한해살이풀이며, 따뜻한 기후의 양토에서 검은 빛을 띄는 흙에서 잘 자라며, 녹말, 단백질, 영양가가 높고 향미가 좋으며, 한방에서는 해열, 해독의 약제로 이용되며, 피부에는 피부병을 치료하게 되는 바, 표백 및 살균 작용을 하게 되고, 각질을 제거하게 되고 특히 녹두껍질이 안구를 맑게 하므로 사용할 때에 눈에 들어가더라도 녹두에 의하여 눈의 자극을 방지하게 된다.The mung bean is a perennial plant of the dicotyledonous plant rosewood, legume, grows well in the soil with black light in the warm climate loam, starch, protein, high nutritional value and good flavor, in the oriental medicine as antipyretic, detoxification agent It is used, the skin is to treat the skin disease, the bleaching and sterilizing action, to remove the dead skin and especially mungbean shells to clear the eye, so even when you enter the eye when used to prevent eye irritation by the green beans.

그리고 녹두는 당질과 단백질이 주성분이고, 통과 달리 당질함량이 높고, 당질 중에서 전분이 많이 함유되어 있고, 무기성분 중에서 칼슘, 인, 철, 칼륨 등이 함유되어 있으며, 아밀라제, 인버타제, 우레아제 등과 같은 소화효소가 있어 소화를 촉진하고, 혈압강하, 소염, 해열, 조열 등으로 작용하게 되며, 한방에서는 성질이 차고 맛이 달며 족이 없으며 기를 보하고 열독을 없애고 발매, 응저, 창질을 치료하고, 술독, 식중독을 풀어준다.Mung bean is composed of sugars and proteins as main ingredients, high sugar content, high starch content in sugars, calcium, phosphorus, iron, potassium, etc. in inorganic ingredients, and amylase, invertase, urease, etc. Digestive enzymes promote digestion, lower blood pressure, anti-inflammatory, antipyretic, diarrhea, etc. In Chinese medicine, the nature is cold and sweet, there is no family, and the qi, eliminating heat poison, releasing, coagulation, wounding, drinking poison , To release food poisoning.

상기 백지(白芷)는 쌍떡잎식물 산형화목 미나리과의 두해살이 또는 세해살이풀이며, 산골짜기 냇가에서 자라고 풀 전체에 털이 없고 뿌리줄기는 매우 굵으며 수염뿌리가 많으며, 가을철에 땅을 파서 채취하여 햇볕에 말린 것이며, 한방에서는 뿌리를 말려 만든 생약을 이용하게 되고, 맵고 화끈한 성질이 있어 발한, 진정, 진통, 정혈, 감기, 두통, 통경, 치통에 처방되며, 피부에는 6,7월에 채집하여 수명과 뿌리를 버리고 깨끗이 씻어서 물이 스며들게 한 후, 썬 것을 햇볕에 말려 생것을 사용하게 되고, 피부를 희고 깨끗하게 하고, 융화 기능이 있어 다른 약제에 의하여 발생되는 부작용을 흡수하게 된다.The white paper (白芷) is a two-year-old or three-year-old grass of the dicotyledonous plant Asteraceae, grows in the valley streams, and has no hairs on the grass, the roots are very thick and have many beard roots, and harvested by digging the ground in autumn In herbal medicine, it is used to make herbal medicine made by drying the root. It has spicy and hot nature. It is prescribed for sweating, soothing, pain relief, blood donation, cold, headache, painfulness, toothache. After throwing away the water, wash it cleanly and let the water soak, and then use the raw one to dry the sunburn, make the skin white and clean, and absorb the side effects caused by other drugs.

백급은 다년생 초본으로 높이 30-70㎝ 정도 자라며 괴경은 비후한 다육질에 연결된 삼각상 난형에 황백색이다. 백급은 자란의 괴경으로 8-11월에 뿌리를 캐어 줄기와 수염뿌리 등을 제거하여 깨끗이 씻은 후 내면의 내심이 없어질 정도로 쪄서 조피를 벗겨내고 다시 햇볕에 말리거나 불에 쬐어 말린다. 성분으로는 신선한 백급의 경우, 수분 14.6%, 전분 30.48%, 포도당 1.5%, 정유, 점액질, 블레틸라 만난 (bletilla mannan)이 함유되어 있는데, 블레틸라글루코만난(bletilla-glucomannan)은 만노스 4분자에 포도당 1분자로 이루어진 글루코만난이다. 주요 효능으로는 지혈, 항염 작용 및 보습 작용 등이 있다.White is a perennial herb, grows about 30-70cm in height, and tubers are yellowish white with triangular ovate connected to thick flesh. Pangteum is a tuber that grows in roots in August-November to remove stems and beard roots, and then wash it clean. Ingredients include fresh 10.6% water, 30.48% starch, 1.5% glucose, essential oils, mucus, and bletilla mannan, which are glucose in four molecules of mannose. One molecule of glucomannan. Main effects include hemostasis, anti-inflammatory and moisturizing action.

본 발명에 사용되는 백렴은 박과 식물인 Melothria heterophylla(Lour.) Cogn.의 괴근(塊根)으로 다년생 덩굴성 초본이다. 분지하지 않는 덩굴손이 있으며 뿌리부분은 팽대되어 방추형(紡錘形)의 괴근을 이룬다. 잎은 단엽(單葉)으로 어긋나며 가늘고 긴 잎자루가 있고 변이가 많아서 3갈래로 얕게 갈라지거나 3~5갈래로 깊게 갈라지며 보다 더 갈라지기도 하고 가운데 열편(裂片)은 길고 크며, 엽저는 다극형(多戟形)이다. 꽃은 단성동주로 단생하거나 여러 송이가 엽액에서 모여서 나고, 꽃자루는 가늘고 길며 선상(線狀)이고, 화관(花冠)은 백색으로 삼각(三角)의 종모양이며 5갈래로 깊게 갈라지고, 수꽃에는 3개의 수술이 있고, 암꽃의 자방은 하위자방이다. 열매는 대부분이 긴 원형이고 길이는 2~4㎝이다. 북한의 황해도 이북 및 중국의 여러 지역에서 분포하며, 한방에서는 가을에 뿌리를 캐내어 깨끗이 씻어 신선한 것을 사용하거나 햇볕에 말린 것을 사용하며, 인후종통, 결막염, 임파선결핵, 고환염, 피부습진 등에 처방한다. 백렴의 성분으로는 리그노세릭산(lignoceric acid), 트리코사노익산(tricosanoic acid), 칼레바신 B(calebassine B), 시트룰린(citrulline), 아르기닌(arginine), 글루탐산(glutamic acid), 베타-시토스테롤(beta-sitosterol), 옥타코사노익산(octacosanoic acid)등이 분리된 바 있다(중화본초. 상해과학기술출판사, 1999).The baekryeom used in the present invention is a perennial herbaceous herb of the gourd of Melothria heterophylla (Lour.) Cogn. There is an unbranched tendril and the root part is swollen to form fusiform muscle. The leaves are alternate with single leaves, have long petioles, and there are many variations, so they are divided into three branches shallowly or deeply into three to five branches, and further split, and the middle lobe is long and large, and the leaf bottom is multipolar.多 形). Flowers are monolithic, or several clusters are gathered from lobe, peduncles are thin, long, linear, and corolla is white, triangular bell-shaped, deeply divided into 5 branches, There are three stamens, and the female flower is the lower one. Fruits are mostly long round and 2 ~ 4㎝ long. It is distributed in the north of Hwanghae, North Korea, and in various places in China. In oriental medicine, the roots are dug up and washed in the fall, and fresh or sun-dried. They are prescribed for sore throat, conjunctivitis, lymphadenopathy, testicles, and skin eczema. The components of pneumonia are lignoceric acid, tricosanoic acid, calebasine B, cetrulline, arginine, glutamic acid, and beta-cytosterol. -sitosterol) and octacosanoic acid have been isolated (Chinese Herbs, Shanghai Science and Technology Press, 1999).

백강잠은 에나방과(Bombycidae) 동물인 누에나방의 누에가 백강균에 감염되어 경화병으로 경직사한 충체로 맛이 매우며 독이없다. 백강잠은 어린아이의 경간(驚癎)을 치료하는데 주로 사용된다. 또한 흑간(黑癎)을 덜어주고, 피부가 가려우며 마비된 것과 붕중하혈(崩中下血)을 치료한다고도 알려져 있다.White-flying silkworms are silkworms of the silkworm moth, an animal of Bombycidae. Leuk sleep is mainly used to treat the span of young children. It is also known to relieve black liver, itchy skin and numbness, and to treat subarachnoid blood (崩 中 下 血).

본 발명에 사용한 백부자(Aconitum koreanum)는 미나리아제비과의 여러해살이풀로 경기도(광릉, 천마산)에 분포한다. 줄기는 곧게 서며 높이는 1m에 달한다. 마늘쪽 같은 뿔리가 2-3개씩 발달하며 잎은 어긋난다. 꽃은 7-8월에 피고 연한 황색 또는 황색 바탕에 자줏빛이 돌며 원줄기 끝과 윗부분 잎겨드랑이의 총상꽃차례에 달린다. 꽃잎은 2개로 뒤쪽의 꽃받침 잎 속에 들어 있다. 냄새가 없고 맛은 쓰며 혀끝을 마비시킨다. 주요성분으로는 alkaloid(Hypaconitine, Diterpene), Aconitine 등이 있으며 효능으로는 풍담이 쌓여 일어나는 안면신경 마비, 편두통 또는 두통과 몸이 무겁고 혀에 흰 설태가 끼는 증상에 쓰이며, 경부림프절염과 뱀에 물린데 사용한다.Baekbuja (Aconitum koreanum) used in the present invention is a perennial herb of the Minaridae family, distributed in Gyeonggi-do (Gwangneung, Cheonmasan). The stem stands upright and reaches 1m in height. Two or three horns, like garlic, develop and the leaves are displaced. Flowers bloom in July-August, light purple or yellowish purple, and hang on the end of main stem and upper leaf axil. 2 petals in the back of calyx leaf. No smell, taste bitter and numb the tip of the tongue. Its main ingredients include alkaloids (Hypaconitine, Diterpene) and Aconitine.They are used for facial nerve paralysis, migraines or headaches caused by abundant winds, headaches and heavy body and white tongue on the tongue, and cervical lymphadenitis and snake bites. use.

천화분은 우리나라 전국 각지에 자생하는 하늘타리(>Trichosanthes kirillowii Max.) 또는 노랑하늘타리(>T. killillowii Max. var Japonicum KITAMURA)의 껍질을 벗긴 뿌리를 햇볕에 말린 것이다. 불균밀한 원주형의 비대한 뿌리로서 당황색을 띄고 있다. 횡단면에는 폭이 넓은 방사조직과 황색의 반점 또는 작은 구멍이 있으며 불규칙한 황갈색의 유관속이 뻗어 있다. 채취시기는 봄과 가을이며, 조피를 벗겨내고 햇볕에 말린 것으로 해열, 지갈, 피부질환치료 등의 효능을 가지고 있어 예로부터 한약재로 쓰이고 있다. Chunhwahwa is a sun-dried root of the bark (> Trichosanthes kirillowii Max.) Or yellow sky (> T. Killillowii Max.var Japonicum KITAMURA) that grows in Korea. It is an embarrassing yellowish root with an inhomogeneous columnar root. The cross section has wide radial tissue, yellow spots or small holes, and irregular yellowish brown tubes extending. The harvest time is spring and autumn, peeling off the skin and dried in the sun, and it has been used as an herbal medicine since it has the effects of antipyretic, jigal and skin disease treatment.

감송향(Nardostachys jatamansi, NJ)은 몇몇 아시아 국각들에서 강장제, 자극제 및 항경련제로 광범위하게 사용되었을 뿐 아니라, 간질, 병적 흥분, 심계 항진 및 경련을 치료하는데도 사용되어 왔다 (Bagchi, A., 등, Planta Med., 57, 9697 (1991)). 야타만시산(Jatamansic acid) 및 야타만손(Jatamansone)과 같은 다양한 세스퀴테르펜들(sesquiterpenes), 리그난, 및 네오리그난이 뿌리에 존재한다 (Chatterji, A, 등, National Institute of Science Communication, vol. 5, pp 99-100 (1997); Arora, RB., Indian Council of Medical Research. vol. 51 (1965)).Nardostachys jatamansi (NJ) has been used extensively as a tonic, irritant and anticonvulsant in several Asian countries, as well as to treat epilepsy, pathological excitement, palpitations and cramps (Bagchi, A., et al. , Planta Med., 57, 9697 (1991)). Various sesquiterpenes, lignans, and neolignans such as Yatamansic acid and Jatamansone are present in the roots (Chatterji, A, et al., National Institute of Science Communication, vol. 5, pp 99-100 (1997); Arora, RB., Indian Council of Medical Research.vol. 51 (1965)).

본 발명에 따른 한약추출물은 이상의 14종을 알콜추출함을 특징으로 한다.Chinese herbal extract according to the present invention is characterized in that the alcohol extraction of more than 14 species.

이들 성분을 모두 한약 제조시 사용되는 통상의 건조된 약재형태의 것을 의미한다. 상기 각 성분이 상, 하한의 범위를 벗어날 경우 효과가 미약하거나 없게 된다.All of these ingredients are in the form of conventional dried medicine used in the manufacture of Chinese medicine. If each component is outside the upper and lower limits, the effect is weak or absent.

상기한 조성을 갖는 본 발명의 한약추출물은 15일간 알콜로 실온에서 추출한다.Herbal extract of the present invention having the above composition is extracted with alcohol for 15 days at room temperature.

이하, 제조예 및 실시예를 들어 본 발명을 상세히 설명하지만 본 발명이 이를 예로만 한정되는 것은 아니다.
Hereinafter, the present invention will be described in detail with reference to Preparation Examples and Examples, but the present invention is not limited thereto.

[제조예 1][Production Example 1]

1. 원료분쇄 공정1. Raw material grinding process

녹두 40g, 백지 40g, 백급 40g, 백렴 40g, 백강잠 40g, 백부자 40g, 천화분 40g, 감송향 20g, 삼내자 20g, 곽향 20g, 영릉향 8g, 방풍 8g, 고본 8g, 조각자 4g을 분쇄기에 넣고 분쇄하였다. 40g green beans, 40g white paper, 40g white wheat, 40g white rice, 40g white baekja, 40g white bean 40g, 40g chrysanthemum, 20g ginseng, 20g ginseng, 20g gwaenghyang 20g, 8g Yeongneung, 8g windproof, 8g gobon, 8g flakes, 4g .

2. 분쇄된 분말 368g에 80% 알콜 4ℓ에 침지시켜 실온에서 15일간 추출하였다.2. 368 g of the ground powder was immersed in 4 L of 80% alcohol and extracted for 15 days at room temperature.

3. 15일 후 필터로 걸러서 100㎖ 스프레이 용기에 담아 포장하였다.
3. After 15 days, filtered and packed in a 100 ml spray bottle.

[시험예 1][Test Example 1]

제조예 1에서 얻어진 추출액을 2010년 3월부터 9월까지 내원한 여드름, 기미 환자에게 아침, 저녁 세안 후에 1일 2회 2개월간 얼굴에 바르게 하였다. 다음의 표는 그 결과를 나타낸다.The extract obtained in Production Example 1 was applied to the acne and blemish patients who visited from March to September 2010 on the face twice a day for two months after washing the morning and evening. The following table shows the results.

Figure pat00001
Figure pat00001

Claims (1)

여드름 치료 및 피부상태 개선용 한약추출물에 있어서 녹두 7 내지 8 중량부, 백지 7 내지 8 중량부, 백급 7 내지 8 중량부, 백렴 7 내지 8 중량부, 백강잠 7 내지 8 중량부, 백부자 7 내지 8 중량부, 천화분 7 내지 8 중량부, 감송향 3 내지 4 중량부, 삼내자 3 내지 4 중량부, 곽향 3 내지 4 중량부, 영릉향 1.4 내지 1.6 중량부, 방풍 1.4 내지 1.6 중량부, 고본 1.4 내지 1.6 중량부, 조각자 0.7 내지 0.8 중량부와 80% 알콜 700㎖ 내지 800㎖로 추출하는 것을 특징으로 하는 여드름 치료 및 피부상태 개선용 한약추출물.In the herbal extracts for the treatment of acne and skin improvement, 7 to 8 parts by weight, 7 to 8 parts by weight of white paper, 7 to 8 parts by weight, baekryeom 7 to 8 parts by weight, 7 to 8 parts by weight of Baekjap, 7 to 8 parts by weight Parts by weight, 7 to 8 parts by weight of cheonhwa, 3 to 4 parts by weight of persimmon, 3 to 4 parts by weight of Samjaja, 3 to 4 parts by weight of Yeokneung, 1.4 to 1.6 parts by weight of Yeongneung, 1.4 to 1.6 parts by weight of windproof, and main body 1.4 Chinese medicine extract for treating acne and improving skin condition, characterized in that extracted from 1.6 parts by weight, 0.7 to 0.8 parts by weight and 700ml to 800ml of 80% alcohol.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104352697A (en) * 2014-11-06 2015-02-18 黄荣棉 External use composition for treating leuconychia
CN108938928A (en) * 2018-10-17 2018-12-07 王泽众 For treating the Chinese herbal medicine paste and preparation method thereof of fracture

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104352697A (en) * 2014-11-06 2015-02-18 黄荣棉 External use composition for treating leuconychia
CN108938928A (en) * 2018-10-17 2018-12-07 王泽众 For treating the Chinese herbal medicine paste and preparation method thereof of fracture

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