CN106975040B - Suppository and preparation method thereof - Google Patents
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a suppository and a preparation method thereof. The suppository is prepared by preparing ointment from radix sophorae flavescentis, radix stemonae, fructus cnidii, hairyvein agrimonia herb and callicarpa bodinieri leaf and adding proper auxiliary materials. The suppository has the effects of clearing away heat and toxic materials, removing blood stasis, astringing, killing parasites and relieving itching, and is suitable for treating and preventing gynecological common diseases such as female mycotic vaginitis, trichomonas vaginitis, bacterial vaginitis, gonococcal vaginitis, cervicitis, cervical erosion, leukorrhagia, senile vaginitis and the like.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a suppository and a preparation method thereof.
Background
A suppository for treating gynecological inflammation is prepared from radix Sophorae Flavescentis, radix Stemonae, fructus Cnidii, herba et Gemma Agrimoniae, folium Callicarpae Formosanae, Alumen, Borneolum Syntheticum, Camphora, and boric acid, and has effects of clearing away heat and toxic materials, removing blood stasis, astringing, killing parasite, and relieving itching, and can be used for treating and preventing gynecological diseases such as female mycotic vaginitis, trichomonal vaginitis, bacterial vaginitis, gonococcal vaginitis, cervicitis, cervical erosion, leukorrhagia, and senile vaginitis. The suppository is a solid preparation prepared from the medicine and a proper matrix and provided with a certain shape for administration in a human body cavity, is solid at normal temperature, can be quickly softened and melted or dissolved in secretion at body temperature after being plugged into the cavity, and gradually releases the medicine to generate local or systemic effect. Therefore, the suppository has the function of being irreplaceable by oral medicines in the aspect of treating gynecological diseases, the transportation and storage conditions of the traditional Chinese medicine suppository are quite strict, and the temperature of the traditional Chinese medicine suppository is higher than 30 ℃, so that the suppository can be softened or melted. The softened or melted suppository is cooled again and re-coagulated to generate the phenomenon of the surface speckles of the suppository body, and the phenomenon has great influence on the quality of the suppository. Therefore, the research and development of the Baicao Fuyanqing suppository which has good recondensation and no speckles have important significance for the transportation, storage and quality control of products.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a suppository and a preparation method; aiming at the prior art, the invention solves the problem of the occurrence of the spot on the surface of the suppository body after the re-coagulation of the suppository by a large number of experimental optimization screens, and provides a product with definite curative effect, stable property and convenient use.
The invention is realized by the following technical scheme:
a suppository is prepared by mixing: 640 parts of radix sophorae flavescentis, 320 parts of radix stemonae, 320 parts of fructus cnidii, 320 parts of hairyvein agrimonia herb and bud and 320 parts of folium callicarpae pedunculatae, taking radix sophorae flavescentis, radix stemonae, fructus cnidii, hairyvein agrimonia herb and bud, adding water for three times, adding 8 times of water for the first time, decocting for 2 hours, adding 6 times of water for the second time, decocting for 2 hours, adding 4 times of water for the third time, decocting for 1 hour, combining decoctions, filtering while hot, concentrating the filtrate to obtain clear paste with the relative density of 1.08-1.10 at 25 ℃, adding 95% ethanol to ensure that the ethanol content reaches 60%, standing for 24 hours, taking supernatant, filtering, recovering ethanol from the filtrate, concentrating to obtain thick paste with the relative density of 1.30-1.35 at 25 ℃, adding auxiliary materials.
Wherein the dosage of the raw materials and the auxiliary materials is as follows: 5 to 25 percent of ointment, 0.1 to 1 percent of alum, 0.5 to 5 percent of boric acid, 0.1 to 1 percent of camphor, 0.05 to 0.5 percent of borneol, 5 to 65 percent of polyoxyl (40) stearate and 15 to 80 percent of polyethylene glycol 400.
Through optimization, the dosage of the raw materials and the auxiliary materials is as follows: 16 to 20 percent of ointment, 0.2 to 0.8 percent of alum, 2 to 4 percent of boric acid, 0.2 to 0.8 percent of camphor, 0.1 to 0.4 percent of borneol, 40 to 55 percent of polyoxyl (40) stearate and 21 to 39 percent of polyethylene glycol 400.
Through further optimization, the dosage of the raw materials and the auxiliary materials is as follows: 18.25% of ointment, 0.5% of alum, 3% of boric acid, 0.5% of camphor, 0.25% of borneol, 49% of polyoxyl (40) stearate and 40028.5% of polyethylene glycol.
Test example: whether the surface of the suppository body has the spots after re-coagulation is taken as an assessment index, and the influence of the types and the dosages of different auxiliary materials on the appearance of the Baicao Fuyanqingshuan suppository is optimized and screened.
Firstly, screening the types of auxiliary materials:
1. the sample preparation method comprises the following steps: pulverizing Alumen and boric acid into fine powder; the preparation method comprises the steps of adding water into radix sophorae flavescentis, radix stemonae, fructus cnidii, hairyvein agrimonia herb and folium callicarpae pedunculatae, decocting for three times, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 2 hours for the second time, adding 4 times of water for the third time, decocting for 1 hour, combining decoction liquids, filtering while hot, concentrating filtrate to obtain clear paste with the relative density of 1.08-1.10 (25 ℃), adding 95% ethanol to enable the alcohol content to reach 60%, standing for 24 hours, taking supernate, filtering, recovering ethanol from the filtrate, concentrating the filtrate to be thick paste with the relative density of 1.30-1.35(25 ℃), adding polyethylene glycol 400, stirring uniformly, adding alum and boric acid, heating and stirring uniformly. Heating adjuvant to melt, adding into the above medicinal liquid, and stirring: dissolving Borneolum and Camphora with small amount of ethanol, adding, stirring, and molding to obtain the final product, and measuring melting time limit of the obtained sample.
2. Auxiliary material type screening table
3. And (4) analyzing results: from the above results, it can be seen that different water-soluble suppository adjuvant combinations have certain influence on whether the surface of the suppository after re-coagulation has spots, and the determination result of sample 5 in the above formulation is better, so we initially select the adjuvant type as the combination of polyethylene glycol 400 and polyoxyl (40) stearate.
Secondly, screening the dosage of auxiliary materials:
after the types of the auxiliary materials in the prescription are determined, the dosage of the auxiliary materials is optimized and screened.
1. The sample preparation method comprises the following steps: pulverizing Alumen and boric acid into fine powder; the preparation method comprises the steps of adding water into radix sophorae flavescentis, radix stemonae, fructus cnidii, hairyvein agrimonia herb and folium callicarpae pedunculatae, decocting for three times, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 2 hours for the second time, adding 4 times of water for the third time, decocting for 1 hour, combining decoction liquids, filtering while hot, concentrating filtrate to obtain clear paste with the relative density of 1.08-1.10 (25 ℃), adding 95% ethanol to enable the alcohol content to reach 60%, standing for 24 hours, taking supernate, filtering, recovering ethanol from the filtrate, concentrating the filtrate to be thick paste with the relative density of 1.30-1.35(25 ℃), adding polyethylene glycol 400, stirring uniformly, adding alum and boric acid, heating and stirring uniformly. Heating polyoxyl (40) stearate to melt, adding into the above medicinal liquid, and stirring; dissolving Borneolum Syntheticum and Camphora in small amount of ethanol, adding, stirring, and molding. Placing the suppository in a constant temperature box of 40 deg.C for 30min, taking out, cooling, removing the suppository shell, and observing.
2. Dosage statistical table
Note: other amounts refer to the total amount of alum, boric acid, camphor, borneol.
3. And (4) analyzing results: from the above measurement results, it can be seen that the Baicaofu anti-inflammatory suppository prepared by using the ointment in an amount of 5% -25%, the polyoxyl (40) stearate in an amount of 5% -65% and the polyethylene glycol 400 in an amount of 15% -80% has no speckles after recondensation, so the amount range screened by us is reasonable.
4. And (3) verification experiment:
proved by verification, when the dosage of the ointment is less than 5 percent or more than 25 percent, the dosage of the polyoxyl (40) stearate is less than 5 percent or more than 65 percent, and the dosage of the polyethylene glycol 400 is less than 15 percent or more than 80 percent, the prepared Baicao Fuyanqing suppository has more spots after recondensation, and can not meet the basic requirements of Chinese pharmacopoeia on the Chinese suppository, thereby further explaining that the dosage range screened in the prior art is reasonable and feasible.
Thirdly, optimizing the test:
in order to better optimize and screen the dosage of the herbal gynecological inflammation-clearing suppository raw auxiliary materials and simultaneously enable the properties of the sample after reagglutination to achieve a more ideal effect, the optimal screening is further carried out within the dosage range after the screening.
1. The sample preparation method comprises the following steps: pulverizing Alumen and boric acid into fine powder; the preparation method comprises the steps of adding water into radix sophorae flavescentis, radix stemonae, fructus cnidii, hairyvein agrimonia herb and folium callicarpae pedunculatae, decocting for three times, adding 8 times of water for 2 hours for the first time, adding 6 times of water for 2 hours for the second time, adding 4 times of water for the third time, decocting for 1 hour, combining decoction liquids, filtering while hot, concentrating filtrate to obtain clear paste with the relative density of 1.08-1.10 (25 ℃), adding 95% ethanol to enable the alcohol content to reach 60%, standing for 24 hours, taking supernate, filtering, recovering ethanol from the filtrate, concentrating the filtrate to be thick paste with the relative density of 1.30-1.35(25 ℃), adding polyethylene glycol 400, stirring uniformly, adding alum and boric acid, heating and stirring uniformly. Heating polyoxyl (40) stearate to melt, adding into the above medicinal liquid, and stirring; dissolving Borneolum Syntheticum and Camphora in small amount of ethanol, adding, stirring, and molding. Placing the suppository in a constant temperature box of 40 deg.C for 30min, taking out, cooling, removing the suppository shell, and observing.
2. Dosage statistical table
3. And (4) analyzing results: as can be seen from the above measurement results, after further optimization, the surface properties of the suppository after re-coagulation are further improved when the dosage of the ointment is between 16% and 20%, the dosage of polyoxyl (40) stearate is between 40% and 55%, and the dosage of polyethylene glycol 400 is between 21% and 39%, wherein the effect of the formula 3 is optimal.
The specific implementation mode is as follows:
example 1: 640g of radix sophorae flavescentis, 320g of radix stemonae, 320g of fructus cnidii, 320g of hairyvein agrimonia herb and bud and 320g of folium callicarpae pedunculatae, taking radix sophorae flavescentis, radix stemonae, fructus cnidii, hairyvein agrimonia herb and folium callicarpae, decocting with water for three times, adding 8 times of water for the first time, decocting for 2 hours, adding 6 times of water for the second time, decocting for 2 hours, adding 4 times of water for the third time, decocting for 1 hour, combining decoctions, filtering while hot, concentrating the filtrate to obtain a clear paste with the relative density of 1.08-1.10 at 25 ℃, adding 95% ethanol to enable the ethanol content of the clear paste to reach 60%, standing for 24 hours, taking supernate, filtering, recovering ethanol from the filtrate, concentrating to obtain a thick paste with the relative density of 1.30-.
Example 2: 5g of ointment, 0.5g of alum, 3g of boric acid, 0.5g of camphor, 0.25g of borneol, 65g of polyoxyl (40) stearate and 40025.75 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 3: 25g of ointment, 0.5g of alum, 3g of boric acid, 0.5g of camphor, 0.25g of borneol, 5g of polyoxyl (40) stearate and 40065.75 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 4: 18.75g of ointment, 0.5g of alum, 3g of boric acid, 0.5g of camphor, 0.25g of borneol, 62g of polyoxyl (40) stearate and 40015 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 5: 10.75g of ointment, 0.5g of alum, 3g of boric acid, 0.5g of camphor, 0.25g of borneol, 5g of polyoxyl (40) stearate and 40080 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 6: 20g of ointment, 0.5g of alum, 3g of boric acid, 0.5g of camphor, 0.25g of borneol, 50.75g of polyoxyl (40) stearate and 40025 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 7: 16g of ointment, 0.5g of alum, 3g of boric acid, 0.5g of camphor, 0.25g of borneol, 44.75g of polyoxyl (40) stearate and 40035 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 8: 18.25g of ointment, 0.5g of alum, 3g of boric acid, 0.5g of camphor, 0.25g of borneol, 49g of polyoxyl (40) stearate and 40028.5 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 9: 19.75g of ointment, 0.5g of alum, 3g of boric acid, 0.5g of camphor, 0.25g of borneol, 55g of polyoxyl (40) stearate and 40021 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 10: 16.75g of ointment, 0.5g of alum, 3g of boric acid, 0.5g of camphor, 0.25g of borneol, 40g of polyoxyl (40) stearate and 40039 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 11: 18.25g of ointment, 0.1g of alum, 2.65g of boric acid, 1g of camphor, 0.5g of borneol, 49g of polyoxyl (40) stearate and 40028.5 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 12: 18.25g of ointment, 1g of alum, 3.1g of boric acid, 0.1g of camphor, 0.05g of borneol, 49g of polyoxyl (40) stearate and 40028.5 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 13: 18.25g of ointment, 0.5g of alum, 0.5g of boric acid, 1g of camphor, 0.25g of borneol, 49g of polyoxyl (40) stearate and 40030.5 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 14: 18.25g of ointment, 0.1g of alum, 5g of boric acid, 0.1g of camphor, 0.05g of borneol, 48g of polyoxyl (40) stearate and 40028.5 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 15: 18.25g of ointment, 0.2g of alum, 3.75g of boric acid, 0.2g of camphor, 0.1g of borneol, 49g of polyoxyl (40) stearate and 40028.5 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 16: 18.25g of ointment, 0.8g of alum, 2.25g of boric acid, 0.8g of camphor, 0.4g of borneol, 49g of polyoxyl (40) stearate and 40028.5 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 17: 18.8g of ointment, 0.5g of alum, 2g of boric acid, 0.8g of camphor, 0.4g of borneol, 49g of polyoxyl (40) stearate and 40028.5 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Example 18: 18g of ointment, 0.2g of alum, 4g of boric acid, 0.2g of camphor, 0.1g of borneol, 49g of polyoxyl (40) stearate and 40028.5 g of polyethylene glycol.
(1) Mixing the ointment with polyethylene glycol 400, placing in a mixing tank, and stirring;
(2) placing boric acid and Alumen in a material preparing tank, heating, and stirring;
(3) heating and melting polyoxyl (40) stearate, adding the molten polyoxyl (40) stearate into the mixing tank in the step (2), and uniformly stirring;
(4) dissolving camphor and borneol with a small amount of ethanol, adding into the mixing tank of (3), and stirring;
(5) controlling the temperature of the liquid medicine at 50-70 ℃, filling, cooling and preparing the required suppository.
Claims (3)
1. A suppository, characterized by: 640 parts of radix sophorae flavescentis, 320 parts of radix stemonae, 320 parts of fructus cnidii, 320 parts of hairyvein agrimonia herb and bud and 320 parts of beautyberry leaf, wherein the radix sophorae flavescentis, the radix stemonae, the fructus cnidii, the hairyvein agrimonia herb and bud are decocted in water for three times, 8 times of water is added for the first time, 2 hours is decocted in water for the second time, 4 times of water is added for the third time, 1 hour is decocted in water for the third time, decoction liquid is combined, hot filtration is carried out, filtrate is concentrated to clear paste with the relative density of 1.08-1.10 at 25 ℃, 95% ethanol is added to ensure that the ethanol content reaches 60%, standing is carried out for 24 hours, supernatant liquid is taken and filtered, the filtrate is recovered with ethanol and concentrated to thick paste with the relative density of 1.30-1.: 5 to 25 percent of ointment, 0.1 to 1 percent of alum, 0.5 to 5 percent of boric acid, 0.1 to 1 percent of camphor, 0.05 to 0.5 percent of borneol, 5 to 65 percent of polyoxyl (40) stearate and 15 to 80 percent of polyethylene glycol 400.
2. A suppository according to claim 1, wherein: 16 to 20 percent of ointment, 0.2 to 0.8 percent of alum, 2 to 4 percent of boric acid, 0.2 to 0.8 percent of camphor, 0.1 to 0.4 percent of borneol, 40 to 55 percent of polyoxyl (40) stearate and 21 to 39 percent of polyethylene glycol 400.
3. A suppository according to claim 2, wherein: 18.25% of ointment, 0.5% of alum, 3% of boric acid, 0.5% of camphor, 0.25% of borneol, 49% of polyoxyl (40) stearate and 40028.5% of polyethylene glycol.
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| CN201610026079 | 2016-01-15 | ||
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| CN201710046766.7A Active CN106975040B (en) | 2016-01-15 | 2017-01-15 | Suppository and preparation method thereof |
| CN201710046768.6A Pending CN106975042A (en) | 2016-01-15 | 2017-01-15 | A kind of suppository and preparation method thereof |
| CN201710045738.3A Active CN106975037B (en) | 2016-01-15 | 2017-01-15 | Suppository and preparation method thereof |
| CN201710048381.4A Pending CN106974884A (en) | 2016-01-15 | 2017-01-15 | A kind of suppository and preparation method thereof |
| CN201710046767.1A Active CN106975041B (en) | 2016-01-15 | 2017-01-15 | Suppository and preparation method thereof |
| CN201710045739.8A Pending CN106975038A (en) | 2016-01-15 | 2017-01-15 | A kind of suppository and preparation method thereof |
| CN201710045740.0A Pending CN106975039A (en) | 2016-01-15 | 2017-01-15 | A kind of suppository and preparation method thereof |
| CN201710046769.0A Pending CN106975043A (en) | 2016-01-15 | 2017-01-15 | A kind of suppository and preparation method thereof |
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| CN201710045738.3A Active CN106975037B (en) | 2016-01-15 | 2017-01-15 | Suppository and preparation method thereof |
| CN201710048381.4A Pending CN106974884A (en) | 2016-01-15 | 2017-01-15 | A kind of suppository and preparation method thereof |
| CN201710046767.1A Active CN106975041B (en) | 2016-01-15 | 2017-01-15 | Suppository and preparation method thereof |
| CN201710045739.8A Pending CN106975038A (en) | 2016-01-15 | 2017-01-15 | A kind of suppository and preparation method thereof |
| CN201710045740.0A Pending CN106975039A (en) | 2016-01-15 | 2017-01-15 | A kind of suppository and preparation method thereof |
| CN201710046769.0A Pending CN106975043A (en) | 2016-01-15 | 2017-01-15 | A kind of suppository and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103800492A (en) * | 2014-03-14 | 2014-05-21 | 通化茂祥制药有限公司 | Anti-cervical erosion suppository and preparation method thereof |
| CN103920081A (en) * | 2014-05-09 | 2014-07-16 | 任明 | Purpose of pharmaceutical composition |
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| US6200590B1 (en) * | 1998-08-10 | 2001-03-13 | Naphcare, Inc. | Controlled, phased-release suppository and its method of production |
| CN1224414C (en) * | 2002-11-15 | 2005-10-26 | 贵州长生制药有限责任公司 | Suppository for treating gynecopathy and its preparation technology |
| WO2013052615A1 (en) * | 2011-10-04 | 2013-04-11 | Polytechnic Institute Of New York University | Modified sophorolipids for the inhibition of plant pathogens |
| CN103520604B (en) * | 2013-10-11 | 2016-02-24 | 哈尔滨欧替药业有限公司 | Baicao Fuyanqing vaginal expansion plug and preparation method thereof and detection method |
| CN104224687A (en) * | 2014-09-28 | 2014-12-24 | 武汉药谷生物工程有限公司 | Isoconazole nitrate vaginal suppository and preparing method thereof |
| CN105534879B (en) * | 2016-01-15 | 2021-06-18 | 贵州双升制药有限公司 | Suppository and preparation method thereof |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103800492A (en) * | 2014-03-14 | 2014-05-21 | 通化茂祥制药有限公司 | Anti-cervical erosion suppository and preparation method thereof |
| CN103920081A (en) * | 2014-05-09 | 2014-07-16 | 任明 | Purpose of pharmaceutical composition |
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| CN106975037A (en) | 2017-07-25 |
| CN106975043A (en) | 2017-07-25 |
| CN106975039A (en) | 2017-07-25 |
| CN106975040A (en) | 2017-07-25 |
| CN106975038A (en) | 2017-07-25 |
| CN106975041A (en) | 2017-07-25 |
| CN106975041B (en) | 2020-07-24 |
| CN106975037B (en) | 2020-06-16 |
| CN106974884A (en) | 2017-07-25 |
| CN106975042A (en) | 2017-07-25 |
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