CN103565990A - Method for preparing anti-cervical erosion suppository - Google Patents
Method for preparing anti-cervical erosion suppository Download PDFInfo
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- CN103565990A CN103565990A CN201210277184.7A CN201210277184A CN103565990A CN 103565990 A CN103565990 A CN 103565990A CN 201210277184 A CN201210277184 A CN 201210277184A CN 103565990 A CN103565990 A CN 103565990A
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Abstract
The invention mainly provides a new method for preparing an anti-cervical erosion suppository, wherein a water extraction and alcohol precipitation method in the previous method is changed into an alcohol extraction method. The method shortens the time of extraction and increases the yield, and also reduces the suppository cost overall and improves the production efficiency.
Description
Technical field
The invention belongs to the field of Chinese medicines, is a kind of new technology of preparing Chinese medicine.
Background technology
XIAOMI SHUAN is the tcm product that ten thousand logical Pharmaceuticaies are produced, and has the effect of " heat-clearing and toxic substances removing, removing dampness and killing parasites, putrefaction-removing granulation-promoting ", for due to damp invasion of lower energizer leukorrheal diseases, card is shown in that profuse leukorrhea, yellow skin, matter are thick, stench, pudendal pruritus; Trichomonal vaginitis, colpitis mycotica, nonspecific vaginitis, cervical erosion are shown in above-mentioned disease person.Its preparation method adopts standard of recording of < < Chinese Pharmacopoeia > > version in 2010.Original prescription and method for making are as follows:
[prescription]
Stem and leaf of Radix Ginseng saponin 25g Radix Arnebiae (Radix Lithospermi) 500g
Cortex Phellodendri 500g Radix Sophorae Flavescentis 500g
Dried Alumen 400g Borneolum Syntheticum 200g
Catechu 500g
[method for making]
Above seven tastes, catechu, alumen powder are broken into fine powder, Borneolum Syntheticum porphyrize; Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi) decoct with water three times, 2 hours for the first time, for the second time, for the third time each 1 hour, collecting decoction, filters, and filtrate is concentrated into the clear paste that relative density is 1.10 (80 ℃), add ethanol make containing alcohol amount be 75%, standing 24 hours, filter, reclaim ethanol, being concentrated into relative density is the thick paste of 1.36 (80 ℃), dry, pulverize into fine powder, mix with above-mentioned fine powder and stem and leaf of Radix Ginseng saponin's powder; Separately get polyoxyethylene monostearate and glycerol 22g, Hybrid Heating fusing, temperature remains on 40 ± 2 ℃, adds above-mentioned fine powder, stirs evenly, and injects suppository mold, cooling, makes 1000, obtains.
Radix Sophorae Flavescentis is the plant that pulse family Radix Sophorae Flavescentis belongs to.Main containing matrine, oxymatrine, oxidation sophocarpine, sophoridine, the other matrine of dextrorotation, dextrorotation Iosmatrine, the alkaloids such as dextrorotation sophoranl, there is heat clearing and damp drying, parasite killing, the effect of diuresis, for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Cortex Phellodendri: be the dry bark of rutaceae wampee or Cortex Phellodendri, nature and flavor bitter cold, has heat clearing and damp drying, pathogenic fire purging is except steaming, the effect of detoxification sore treatment.Main component is berberine (Berberine). separately containing phellodendrine (Phello dendrine), magnoflorine (Magnoflorine), jateorhizine (Jatrorrhizine), palmatine (palmatine, Palmatine), the multiple alkaloid such as candicine (Candicine), Dauricine (Menisperine).
Radix Arnebiae (Radix Lithospermi): be the root of comfrey Radix Arnebiae (Radix Lithospermi), the false Radix Arnebiae (Radix Lithospermi) in Xinjiang-Tibet or Yunnan Radix Arnebiae (Radix Lithospermi).Radix Arnebiae (Radix Lithospermi) is containing pigment composition, fatty acid.Pigment composition is naphthoquinone derivatives, there is shikonin (shikonin, Shikonin), acetylshikonin (Acetylshikonin), deoxyshikonin (Deoxyshikonin), isobutyl group shikonin (Isobutyshi-konin), IVS (Isovalerylshikonin), β, beta-dimethyl-acryloyl shikonin (β, β-Dimethyla-crylshikonin), beta-hydroxy-IVS (β-Hydroxyisovalerylshikonin), alkannan (Alkannan), Radix Arnebiae (Radix Lithospermi) red (Alkannin), Alpha-Methyl-n-butyryl shikonin (α-Methyl-n-butyrylshikonin), 3, 4-dimethyl pentene-3-acyl group shikonin (Teracrylshikonin).
Above composition is all dissolved in ethanol.
Summary of the invention
The present invention has mainly been to provide a kind of new method of preparing XIAOMI SHUAN, and its positive beneficial effect is, and the one, shortened the time of extracting, reduced the consumption of solvent, the 2nd, increased yield, reduced on the whole XIAOMI SHUAN cost, improved production efficiency.
Example 1, suppository preparation
Formula:
Stem and leaf of Radix Ginseng saponin 25g Radix Arnebiae (Radix Lithospermi) 500g
Cortex Phellodendri 500g Radix Sophorae Flavescentis 500g
Dried Alumen 400g Borneolum Syntheticum 200g
Catechu 500g
Above seven tastes, catechu, dried Alumen, stem and leaf of Radix Ginseng saponin are ground into fine powder, Borneolum Syntheticum porphyrize, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi) add 60% ethanol and decoct, 1.0-2.0 hour for the first time, for the second time, each 0.5-1.0 hour for the third time, merge extractive liquid,, filter, reclaim ethanol, being concentrated into relative density is the thick paste of 1.3-1.4 (80 ℃), dry, be ground into fine powder, mix with above-mentioned fine powder, separately get polyoxyethylene monostearate and glycerol, Hybrid Heating fusing, temperature remains on 40 ± 2 ℃, add above-mentioned fine powder, stir evenly, inject suppository mold, cooling, obtain.
Example 2, gel preparation.
According to embodiment 1 prescription consumption, with reference to its preparation technology, extraction cream and medical material fine powder are mixed, add appropriate sodium polyacrylate, carbomer, gelatin, Resina persicae, glycerol, sodium hydroxide, distilled water, be uniformly mixed plastic, pack container into, obtain.
Example 3, soft capsule preparation.
According to embodiment 1 prescription consumption, with reference to its preparation technology, extraction cream and medical material fine powder are mixed, add appropriate oil with hydrogenated soybean, Cera Flava, salad oil, stirring and evenly mixing, is pressed into soft capsule, obtains.
Technique comparative illustration before and after improving:
The traditional decoction and alcohol sedimentation technique of 1 former process using, directly adopts alcohol extraction after improving, not only can shorten extraction time, can also improve the yield of effective ingredient, increases curative effect of medication.Experiment contrast index is as follows:
The traditional decoction and alcohol sedimentation technique of 2 former process using, directly adopts alcohol extraction after improving, reduced the consumption of solvent, has shortened extraction time, has reduced the consumption of the energy.
Claims (1)
1. a method of preparing XIAOMI SHUAN, its raw material and preparation method are as follows:
1) raw material:
Stem and leaf of Radix Ginseng saponin 25g Radix Arnebiae (Radix Lithospermi) 500g
Cortex Phellodendri 500g Radix Sophorae Flavescentis 500g
Dried Alumen 400g Borneolum Syntheticum 200g
Catechu 500g
2) preparation method:
A catechu, dried Alumen, stem and leaf of Radix Ginseng saponin are ground into fine powder, standby;
B Borneolum Syntheticum porphyrize, standby;
C Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi) add 60% ethanol and decoct, 1.0-2.0 hour for the first time, for the second time, each 0.5-1.0 hour for the third time, merge extractive liquid,, filter, reclaim ethanol, being concentrated into relative density is the thick paste of 1.3-1.4 (80 ℃), dry, pulverize into fine powder, standby;
The above-mentioned fine powder of d mixes, and separately gets polyoxyethylene monostearate and glycerol, Hybrid Heating fusing, and temperature remains on 40 ± 2 ℃, adds above-mentioned fine powder, stirs evenly, and injects suppository mold, cooling, obtains.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210277184.7A CN103565990A (en) | 2012-07-29 | 2012-07-29 | Method for preparing anti-cervical erosion suppository |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210277184.7A CN103565990A (en) | 2012-07-29 | 2012-07-29 | Method for preparing anti-cervical erosion suppository |
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| Publication Number | Publication Date |
|---|---|
| CN103565990A true CN103565990A (en) | 2014-02-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210277184.7A Pending CN103565990A (en) | 2012-07-29 | 2012-07-29 | Method for preparing anti-cervical erosion suppository |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103800492A (en) * | 2014-03-14 | 2014-05-21 | 通化茂祥制药有限公司 | Anti-cervical erosion suppository and preparation method thereof |
| CN104547185A (en) * | 2014-12-14 | 2015-04-29 | 通化万通药业股份有限公司 | Preparation method of erosion removal suppository |
| CN104784325A (en) * | 2014-05-15 | 2015-07-22 | 刘善奎 | Traditional Chinese medicine suppository for treating cervical erosion |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1672704A (en) * | 2004-03-25 | 2005-09-28 | 一笑堂（湖南）制药有限公司 | Erosion-eliminating effervescent tablet and its prepn |
| CN1679649A (en) * | 2004-04-10 | 2005-10-12 | 毛友昌 | Medicinal composition for cervical erosion and vaginitis and its preparation |
| CN1872206A (en) * | 2006-04-19 | 2006-12-06 | 郭凌云 | Solution agent for eliminating erosion, and preparation method |
-
2012
- 2012-07-29 CN CN201210277184.7A patent/CN103565990A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1672704A (en) * | 2004-03-25 | 2005-09-28 | 一笑堂（湖南）制药有限公司 | Erosion-eliminating effervescent tablet and its prepn |
| CN1679649A (en) * | 2004-04-10 | 2005-10-12 | 毛友昌 | Medicinal composition for cervical erosion and vaginitis and its preparation |
| CN1872206A (en) * | 2006-04-19 | 2006-12-06 | 郭凌云 | Solution agent for eliminating erosion, and preparation method |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103800492A (en) * | 2014-03-14 | 2014-05-21 | 通化茂祥制药有限公司 | Anti-cervical erosion suppository and preparation method thereof |
| CN103800492B (en) * | 2014-03-14 | 2015-10-28 | 通化茂祥制药有限公司 | A kind of XIAOMI SHUAN and preparation method thereof |
| CN104784325A (en) * | 2014-05-15 | 2015-07-22 | 刘善奎 | Traditional Chinese medicine suppository for treating cervical erosion |
| CN104547185A (en) * | 2014-12-14 | 2015-04-29 | 通化万通药业股份有限公司 | Preparation method of erosion removal suppository |
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Application publication date: 20140212 |