CN106109270A - A kind of defying age new cosmetic compositions and preparation method thereof - Google Patents
A kind of defying age new cosmetic compositions and preparation method thereof Download PDFInfo
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- CN106109270A CN106109270A CN201610490027.2A CN201610490027A CN106109270A CN 106109270 A CN106109270 A CN 106109270A CN 201610490027 A CN201610490027 A CN 201610490027A CN 106109270 A CN106109270 A CN 106109270A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
It is an object of the invention to provide a kind of new cosmetic compositions with senile-resistant efficacy, said composition can effectively eliminate free radical, reduce wrinkle of skin generation, thus reaches delay skin aging effect.Said composition composition is as follows: CAPE, propylene glycol, glycerol, 1,3 butanediol, and 1,2 pentanediols, the different monooctyl ester of ferulic acid, HANSHENGJIAO, hyaluronate sodium, disodiumedetate, emulsifying agent, cetearyl alcohol, polymethyl siloxane, vegetable oil, freshener, VB5, preservative, essence, deionized water, refine through simple preparation method and form.
Description
Technical field
The present invention relates to cosmetics processing technique field in daily-use chemical industry, be specifically related to a kind of defying age novel cosmetic group
Compound and preparation method thereof.
Technical background
Skin is the organ that human body is maximum, along with constantly increasing of age can be gradually old and feeble.It is reported most women 25
～within 30 years old, start long wrinkle, and mottle occurs further, skin becomes to relax subsequently, coarse, dim, wrinkle is deepened, and becomes many etc..Skin
The aging of skin is almost with everyone lower half a lifetime, and work, life to people produce negative influence, the process of skin aging
It is divided into inherent and external two processes.
1. intrinsic procedure
Intrinsic procedure refers to as time goes by, and people is increasingly older, and skin there will be some little microgroove, cutis laxas
Deng.The endogenetic mechanisms of skin aging is extremely complex, and relatively representational causes of senescence specifically includes that free radical theory, something lost
Pass gene theory, mitochondrial DNA damage theory and other theories.
1) free radical theory
Free radical is also called free radical, is exactly oxygen-derived free radicals, vivo oxidation metabolism produce.Free radical
Saying it is that Harman proposed in 1956, its centre point includes: free radical is to be prevalent in Living organism, has
The intermediate of elevated chemical activity.Under normal physiological conditions, the generation of machine interior free yl and elimination are in dynamic equilibrium, and one
The destroyed generation that then can cause excessive free radicals of denier balance；Radical pair chromosome, mitochondrion, cell membrane and the connective of excess
The toxic attack of the biological tissues such as tissue can cause the aging of body.
2) theory of genetic gene
Theory of genetic gene, mainly analyzes aging phenomenon from chromosome and gene level.This theory is thought, aging is by certain
Plant the biosis that genetic program determines and expresses on time.With advancing age, modifying gene forfeiture, DNA methylation
The regulation and control such as minimizing, phosphorylation reaction reduction, telomere shortening, the decline of DNA self-repairing capability, proto-oncogene and antioncogene are extremely
Cause chromosome mutation, normal cell excessively to break up and old and feeble performance occurs.Hayflik cell injuring model the earliest is found that
Passage rule, it is believed that developmental process has time succession, control mechanism weakens with age, ultimately results in and declines
Always.
3) mitochondrial DNA damage theory
1980, Miquel and Cowiker proposed the mitochondrion hypothesis of aging, it is believed that the damage of mitochondrial DNA is thin
The molecular basis that born of the same parents are old and feeble and dead, its research in recent years becomes the old and feeble lucky focus of research in the world.From cell biological
Angle is said, the energy 90% that Cellular Oxidation phosphorylation produces, from mitochondrion, for the need of cell life, works as mitochondrial DNA
During damage, the energy of generation reduces, and affects the energy supply of cell, causes the decline of cell, tissue, organ dysfunction, therefore recognize
For, mitochondrial deformation, seepage and to rupture be all the major reason of its aging.Delay mitochondrial destructive process, may extend
Cell survival, and then extend the life-span of body.
4) other theories
Including enzymes activity transformant doctrine, immunological theory, hormone theory, tolemerase, the disappearance etc. of essential trace element.
From varying level and angle, Aging Mechanism done all suppositions.
2. extrinsic process
Extrinsic process is often referred to the impact that skin is caused by the exposure of environment or other forms.Some changes caused.
The most deeper thicker wrinkle, decortication, xerosis cutis, senile plaque etc..Extrinsic factor mainly includes ultraviolet irradiation, medicated cigarette cigarette
Mist, and other bad life habits etc..The existence of extrinsic factor can accelerate the process of skin natural aging.
How one of slow down aging research focus being always cosmetic field, the defying age occurred in the market is made up
Product are of a great variety, mostly add vitamin antioxidants (such as vitamin E, vitamin C), but this kind of antioxidant stability is relatively
Difference, its application is restricted.Containing antioxidant content during scholar's research finds some plants or Chinese herbal medicine in recent years, there is antagonism
Free radical, promotes skin metabolism, delays effect of body aging, but in actual application, existing containing above-mentioned plant or medium-height grass
The wrinkle resistant anti-aging effects effect that the cosmetics of medicament extract play is unsatisfactory.Therefore, a kind of novel crease-resistant defying age of research
Respond well, good stability, extremely it is necessary for cosmetics pure natural skin care compositions.
Summary of the invention
It is an object of the invention to provide a kind of new cosmetic compositions with senile-resistant efficacy, said composition can have
Effect eliminates free radical, reduces wrinkle of skin generation, thus reaches delay skin aging effect.
CAPE is one of main active of propolis, containing 0-dihydroxy (catechol) benzene ring structure, tool
There is strong non-oxidizability, remove free radical, anti-aging effects, whitening function.For removing a kind of common structure of free radical, and
There are two ortho position phenolic hydroxyl groups, make on phenyl ring electron density high, easily autoxidation and colour generation.Bors etc. report, 0-dihydroxy benzenes
Performance antioxidation in flavonoid is played an important role by ring structure.
The present invention is attained in that by technology implementation scheme in detail below
The present invention provides a kind of defying age new cosmetic compositions, the raw material of following weight portion be prepared from: coffee
Acid phenethyl ester 1～30 parts, propylene glycol 1～30 parts, glycerol 1～20 parts, 1,3 butylene glycol 1～10 parts, 1,2-pentanediol 1～20
Part, the different monooctyl ester of ferulic acid 1～30 parts, HANSHENGJIAO 1～2 parts, hyaluronate sodium 0.1～0.5g part, disodiumedetate 0.1
～1.5 parts, emulsifying agent 30～60 parts, cetearyl alcohol 10～30 parts, polymethyl siloxane 5～30 parts, vegetable oil 30～60 parts,
Freshener 1～20 parts, VB55～10 parts, preservative 2～10 parts, essence 1～5 parts, surplus is deionized water.
The present invention provide a kind of defying age new cosmetic compositions, said composition in parts by weight, preferably by under
The raw material composition of row weight portion, CAPE 15 parts, propylene glycol 15 parts, glycerol 10 parts, 1,3 butylene glycol 5 parts, 1,2-penta
Glycol 10 parts, the different monooctyl ester of ferulic acid 15 parts, HANSHENGJIAO 1.5 parts, hyaluronate sodium 0.3g part, disodiumedetate 0.8 part,
Emulsifying agent 45 parts, cetearyl alcohol 20 parts, polymethyl siloxane 20 parts, vegetable oil 45 parts, freshener 10 parts, VB58 parts, anticorrosion
Agent 6 parts, 3 parts of essence, surplus is deionized water.
A kind of defying age new cosmetic compositions that the present invention provides, vegetable oil used is Semen pruni armeniacae oil, American Avocado Tree oil, breast
The mixture of wood fruit oil, consists of Semen pruni armeniacae oil 3～8 parts, American Avocado Tree oil 3～6 parts, shea butter 1～5 parts in parts by weight.
A kind of defying age new cosmetic compositions that the present invention provides, freshener used is menthol.
The present invention provides a kind of defying age new cosmetic compositions, and preservative used is phenoxyethanol.
Prepare the preparation method of defying age new cosmetic compositions of the present invention, comprise the steps:
A) emulsifying agent, cetearyl alcohol, vegetable oil, polymethyl siloxane, HANSHENGJIAO, the different monooctyl ester of ferulic acid are put into oil phase
Pot, is heated to 70～85 DEG C, heat preservation for standby use after waiting all components to dissolve；
B) above-mentioned glycerol, hyaluronate sodium, disodiumedetate, deionized water are put into emulsifying pot, be heated to 70
～85 DEG C, it is incubated 15～30 minutes；
C) by CAPE, glycerol, propylene glycol, 1,2-pentanediol, 1,3 butylene glycol puts into oil phase pot, is heated to 70
～85 DEG C, heat preservation for standby use until completely dissolved；
D) by the emulsifying pot of the oil phase suction step b) in step a) and step c), stir with stir speed (S.S.) for 3000rpm
After mixing 3～5 minutes, then stir 15～45 minutes with stir speed (S.S.) for 30rpm；
E) emulsion in step d) is cooled to 50～55 DEG C, adds above-mentioned VB5, freshener, preservative, essence, stirring
Uniformly.
Preferably prepare the preparation method of defying age new cosmetic compositions of the present invention, comprise the steps:
A) emulsifying agent, cetearyl alcohol, vegetable oil, polymethyl siloxane, HANSHENGJIAO, the different monooctyl ester of ferulic acid are put into oil phase
Pot, is heated to 80 DEG C, heat preservation for standby use after waiting all components to dissolve；
B) above-mentioned glycerol, hyaluronate sodium, disodiumedetate, deionized water are put into emulsifying pot, be heated to 80
DEG C, it is incubated 20 minutes；
C) by CAPE, glycerol, propylene glycol, 1,2-pentanediol, 1,3 butylene glycol puts into oil phase pot, is heated to 78
DEG C, heat preservation for standby use until completely dissolved；
D) by the emulsifying pot of the oil phase suction step b) in step a) and step c), stir with stir speed (S.S.) for 3000rpm
After mixing 4 minutes, then stir 30 minutes with stir speed (S.S.) for 30rpm；
E) emulsion in step d) is cooled to 50～55 DEG C, adds above-mentioned VB5, freshener, preservative, essence, stirring
Uniformly.
Having mainly comprised of described defying age new cosmetic compositions:
1. CAPE.CAPE is one of main active of propolis, containing 0-dihydroxy (catechu
Phenol) benzene ring structure, there is strong antioxidation, free radical can be removed, there is anti-aging effects and whitening function, be this combination
The main component of thing, CAPE weight ratio is 1g～30g/1000g.
2. propylene glycol.It is as a kind of wetting agent in the present invention.
3. glycerol.It is as a kind of wetting agent in the present invention.
4.1,3-butanediols.It is the one of polyhydric alcohol, in the present invention as wetting agent and solvent.
5.1,2-pentanediols.In the present invention as antibacterial.
6. the different monooctyl ester of ferulic acid.There is absorption ultraviolet and the effect of anti-oxidation, also have simultaneously depigmentation and
The function of suppression tryrosinase, generates melanin and has inhibitory action.
7. HANSHENGJIAO.As a kind of emulsifying agent in the present invention.
8. hyaluronate sodium.Having efficient lock water moisture-keeping function and skin repairs group, compact skin, permanent moisturizing,
Prevent dehydration, promote histiocyte regeneration.
9. disodiumedetate.As a kind of chelating agent in the present invention.
10. cetearyl alcohol.Cetearyl alcohol of the present invention, for C16 alcohol and the mixture of C18 alcohol, preferred C16
Alcohol: when the mass ratio of C18 alcohol is 3: 7, can make system stability increase.Its source is through ester exchange by Oleum Gossypii semen, Petiolus Trachycarpi oil,
High pressure adds hydrogen reduction and prepares.It plays the effect of thick stabilization in this formula.
11. polymethyl siloxanes.As a kind of water-repellent additive in the present invention.
Emulsifying agent of the present invention is tween 80, and hydrolecithin, lecithin, glyceryl stearate, PEG-100 are stearic
Acid esters, paregal O, a kind of in sodium lauryl sulphate or their mixing.It is further preferred that described emulsifying agent is PEG-
100 stearates, paregal O, described weight ratio is 30～60g/1000g.
Vegetable oil of the present invention is Semen pruni armeniacae oil, American Avocado Tree oil, shea butter, olive oil, Jojoba oil, Semen Vitis viniferae
Oil, a kind of in macadimia nut oil or their mixing.It is further preferred that described vegetable oil is Semen pruni armeniacae oil, American Avocado Tree oil, breast
Wood fruit oil, described Semen pruni armeniacae oil, American Avocado Tree oil, the weight ratio ratio of shea butter are respectively 30～80g/1000g: 30～60g/
1000g: 10～50g/1000g.Semen pruni armeniacae oil, takes from the peaberry of sweet Fructus Pruni, is unlikely to deteriorate, and has excellent keeping quality, to skin without
Evil, has skin moistening effect；American Avocado Tree oil, takes from the sarcocarp of American Avocado Tree, containing more rich micro constitutent, such as tocopherol, various plant steroid
Alcohol, phytin, carotenoid and Squalene etc..American Avocado Tree oil is widely used as the lubricant of cosmetics to promote skin
Smooth, relatively strong to percutaneous permeability, contribute to making active substance be conveyed in skin, it also has anti-sunlight function in addition；Butyrospermum Parkii
The extraction of oil is derived from cream wood, it is adaptable to anti-aging product, late frost, sensitivity skin and the care product of dry skin.
The Advantageous Effects that the present invention produces is:
1. CAPE is the main component of the present invention, has strong non-oxidizability, whitening and anti-aging effect.
2. Multiple components is mixed with by the compounds of this invention by a certain percentage, for the mechanism of human senility, from multiple
Aspect stops human senility, can provide power endlessly for defying age.
3. vegetable oil selects Semen pruni armeniacae oil, American Avocado Tree oil, shea butter to be used in mixed way with certain proportion, can preferably play anti-
Old and feeble effect, skin care.
Preparation method the most of the present invention is simple, energy-conserving and environment-protective.
Detailed description of the invention
Embodiment 1
The preparation method a kind of defying age novel cosmetic of preparation provided according to the present invention, including component as follows:
CAPE 1～30 parts, propylene glycol 1～30 parts, glycerol 1～20 parts, 1,3 butylene glycol 1～10 parts, 1,2-
Pentanediol 1～20 parts, the different monooctyl ester of ferulic acid 1～30 parts, HANSHENGJIAO 1～2 parts, hyaluronate sodium 0.1～0.5g part, ethylenediamine tetraacetic
Acetic acid disodium 0.1～1.5 parts, emulsifying agent 30～60 parts, cetearyl alcohol 10～30 parts, polymethyl siloxane 5～30 parts, plant
Oil 30～60 parts, freshener 1～20 parts, VB55～10 parts, preservative 2～10 parts, essence 1～5 parts, surplus is deionized water.
Concrete preparation method is as follows:
A) emulsifying agent, cetearyl alcohol, vegetable oil, polymethyl siloxane, HANSHENGJIAO, the different monooctyl ester of ferulic acid are put into oil phase
Pot, is heated to 70～85 DEG C, heat preservation for standby use after waiting all components to dissolve；
B) above-mentioned glycerol, hyaluronate sodium, disodiumedetate, deionized water are put into emulsifying pot, be heated to 70
～85 DEG C, it is incubated 15～30 minutes；
C) by CAPE, glycerol, propylene glycol, 1,2-pentanediol, 1,3 butylene glycol puts into oil phase pot, is heated to 70
～85 DEG C, heat preservation for standby use until completely dissolved；
D) by the emulsifying pot of the oil phase suction step b) in step a) and step c), stir with stir speed (S.S.) for 3000rpm
After mixing 3～5 minutes, then stir 15～45 minutes with stir speed (S.S.) for 30rpm；
E) emulsion in step d) is cooled to 50～55 DEG C, adds above-mentioned VB5, freshener, preservative, essence, stirring
Uniformly.
Embodiment 2
The preparation method a kind of defying age novel cosmetic of preparation provided according to the present invention, including component as follows:
CAPE 1g, propylene glycol 30g, glycerol 20g, 1,3 butylene glycol 1g, 1,2-pentanediol 1g, ferulic acid is different pungent
Ester 30g, HANSHENGJIAO 2g, hyaluronate sodium 0.1g, disodiumedetate 1.5g, emulsifying agent 30g, cetearyl alcohol 30g, poly-
Methylsiloxane 5g, vegetable oil 30g, freshener 1g, VB55g, preservative 10g, essence 1g, surplus is deionized water.
Concrete preparation method is as follows:
A) emulsifying agent, cetearyl alcohol, vegetable oil, polymethyl siloxane, HANSHENGJIAO, the different monooctyl ester of ferulic acid are put into oil phase
Pot, is heated to 70 DEG C, heat preservation for standby use after waiting all components to dissolve；
B) above-mentioned glycerol, hyaluronate sodium, disodiumedetate, deionized water are put into emulsifying pot, be heated to 70
DEG C, it is incubated 15 minutes；
C) by CAPE, glycerol, propylene glycol, 1,2-pentanediol, 1,3 butylene glycol puts into oil phase pot, is heated to 70
DEG C, heat preservation for standby use until completely dissolved；
D) by the emulsifying pot of the oil phase suction step b) in step a) and step c), stir with stir speed (S.S.) for 3000rpm
After mixing 3～5 minutes, then stir 15 minutes with stir speed (S.S.) for 30rpm；
E) emulsion in step d) is cooled to 50～55 DEG C, adds above-mentioned VB5, freshener, preservative, essence, stirring
Uniformly.
Embodiment 3
The preparation method a kind of defying age novel cosmetic of preparation provided according to the present invention, including component as follows:
CAPE 30g, propylene glycol 1g, glycerol 1g, 1,3 butylene glycol 10g, 1,2-pentanediol 20g, ferulic acid is different
Monooctyl ester 1g, HANSHENGJIAO 1g, hyaluronate sodium 0.5g, disodiumedetate 0.1g, emulsifying agent 60g, cetearyl alcohol 10g,
Polymethyl siloxane 30g, vegetable oil 30～60g, freshener 20g, VB510g, preservative 2g, essence 5g, surplus is deionization
Water.
Concrete preparation method is as follows:
A) emulsifying agent, cetearyl alcohol, vegetable oil, polymethyl siloxane, HANSHENGJIAO, the different monooctyl ester of ferulic acid are put into oil phase
Pot, is heated to 85 DEG C, heat preservation for standby use after waiting all components to dissolve；
B) above-mentioned glycerol, hyaluronate sodium, disodiumedetate, deionized water are put into emulsifying pot, be heated to 85
DEG C, it is incubated 30 minutes；
C) by CAPE, glycerol, propylene glycol, 1,2-pentanediol, 1,3 butylene glycol puts into oil phase pot, is heated to 70
～85 DEG C, heat preservation for standby use until completely dissolved；
D) by the emulsifying pot of the oil phase suction step b) in step a) and step c), stir with stir speed (S.S.) for 3000rpm
After mixing 3～5 minutes, then stir 45 minutes with stir speed (S.S.) for 30rpm；
E) emulsion in step d) is cooled to 50～55 DEG C, adds above-mentioned VB5, freshener, preservative, essence, stirring
Uniformly.
Embodiment 4
The preparation method a kind of defying age novel cosmetic of preparation provided according to the present invention, including component as follows:
CAPE 15g, propylene glycol 15g, glycerol 10g, 1,3 butylene glycol 5g, 1,2-pentanediol 10g, ferulic acid is different
Monooctyl ester 15g, HANSHENGJIAO 1.5g, hyaluronate sodium 0.3g, disodiumedetate 0.8g, emulsifying agent 45g, cetearyl alcohol
20g, polymethyl siloxane 20g, vegetable oil 45g, freshener 10g, VB58g, preservative 6g, essence 3g, surplus is deionization
Water.
Concrete preparation method is as follows:
A) emulsifying agent, cetearyl alcohol, vegetable oil, polymethyl siloxane, HANSHENGJIAO, the different monooctyl ester of ferulic acid are put into oil phase
Pot, is heated to 70～85 DEG C, heat preservation for standby use after waiting all components to dissolve；
B) above-mentioned glycerol, hyaluronate sodium, disodiumedetate, deionized water are put into emulsifying pot, be heated to 70
～85 DEG C, it is incubated 15～30 minutes；
C) by CAPE, glycerol, propylene glycol, 1,2-pentanediol, 1,3 butylene glycol puts into oil phase pot, is heated to 70
～85 DEG C, heat preservation for standby use until completely dissolved；
D) by the emulsifying pot of the oil phase suction step b) in step a) and step c), stir with stir speed (S.S.) for 3000rpm
After mixing 3～5 minutes, then stir 15～45 minutes with stir speed (S.S.) for 30rpm；
Emulsion in step d) is cooled to 50～55 DEG C, adds above-mentioned VB5, freshener, preservative, essence, stirring is all
Even.
Embodiment 5
The preparation method a kind of defying age novel cosmetic of preparation provided according to the present invention, including component as follows:
CAPE 22g, propylene glycol 17g, glycerol 12g, 1,3 butylene glycol 7g, 1,2-pentanediol 15g, ferulic acid is different
Monooctyl ester 16g, HANSHENGJIAO 1g, hyaluronate sodium 0.4g, disodiumedetate 1g, emulsifying agent 50g, cetearyl alcohol 25g, poly-
Methylsiloxane 25g, vegetable oil 40g, freshener 15g, VB55g, preservative 10g, essence 4g, surplus is deionized water.
Concrete preparation method is as follows:
E) emulsifying agent, cetearyl alcohol, vegetable oil, polymethyl siloxane, HANSHENGJIAO, the different monooctyl ester of ferulic acid are put into oil phase
Pot, is heated to 70～85 DEG C, heat preservation for standby use after waiting all components to dissolve；
F) above-mentioned glycerol, hyaluronate sodium, disodiumedetate, deionized water are put into emulsifying pot, be heated to 70
～85 DEG C, it is incubated 15～30 minutes；
G) by CAPE, glycerol, propylene glycol, 1,2-pentanediol, 1,3 butylene glycol puts into oil phase pot, is heated to 70
～85 DEG C, heat preservation for standby use until completely dissolved；
H) by the emulsifying pot of the oil phase suction step b) in step a) and step c), stir with stir speed (S.S.) for 3000rpm
After mixing 3～5 minutes, then stir 15～45 minutes with stir speed (S.S.) for 30rpm；
Emulsion in step d) is cooled to 50～55 DEG C, adds above-mentioned VB5, freshener, preservative, essence, stirring is all
Even.
Experimental example 1 investigates the antioxidant effect of embodiment 2-5
Experiment purpose: be purged free radical ability mensuration with commercially available conventional antidotal agent and compare.
Test apparatus and reagent: spectrophotometer SpectronicGENESYS-5, Thermo company of the U.S.；Other reagent
For conventional reagent；Relatively embodiment of the present invention 2-5 anti-apolexis composition, Microbial biomass C, the oxidation resistance of vitamin E.
Test method
(1) mensuration of scavenging ability of DPPH free radical: successively by pH6.8 phosphate buffer 3mL, 0.4mmol/LDPPH without
Hydrous ethanol solution 4mL, 0.2mL testing sample joins in 10mL centrifuge tube and fully mixes, after 30min, centrifugal 10min
(8000r/min), taking supernatant, be mensuration absorbance at 516nm at wavelength, operation repetitive is averaged for 3 times, laboratory sample
Clearance rate=[1-(A1-A2)/A3] to DPPH free radical.In formula, A1 is to add the absorbance of DPPH solution after example reaction,
A2 only adds the light absorption value of sample solution for being not added with DPPH (replacing with dehydrated alcohol), and A3 only adds DPPH and aqueous solution for being not added with sample
Light absorption value.
(2) mensuration of ultra-oxygen anion free radical ability is removed: secure ph is the buffer system (Tris-HCl-of 8.20
EDTA).In 10mL centrifuge tube, add testing sample 0.6mL, add 5.2mL buffer, add 0.045mol/L with pipet
Pyrogallol solution 0.2mL, shakes up rapidly, waits question response after 5 minutes rapidly in dry cuvette, is at 325nm at wavelength
Survey absorbance, be designated as A0, survey again after 10min and be designated as A4.With distilled water replace sample determination light absorption value be designated as respectively B0 and
B4.Operation repetitive is averaged for 3 times, sample suppression ratio=[(B4-B0)-(A4-A0)]/(B4-B0) to superoxide anion.
(3) mensuration of scavenging hydroxyl ability: respectively by 0.4mmol/L crystal violet 1mL, 0.2mol/LpH7.4 phosphoric acid
Buffer 3mL, 0.001mol/L FeSO4Solution 1mL, testing sample 1mL, add in 10mL centrifuge tube, finally add 30%
H2O21mL starts reaction, and after reaction 1h, 12000r/min is centrifuged 5min at room temperature, takes supernatant and measures light absorption value under 510nm
It is designated as C, replaces light absorption value during sample to be designated as C1 with distilled water, replace sample and H with distilled water2O2Time light absorption value be designated as C2.
Operation repetitive is averaged for 3 times, sample clearance rate=(C-C1)/(C2-C1) to hydroxy radical.
Result of the test
The measurement result of table 1 scavenging ability of DPPH free radical
Note: compare with vitamin C,*P ＜ 0.05,**P ＜ 0.01；Compare with vitamin E,△P ＜ 0.05,△△P ＜ 0.01.
Result shows: the present invention removes the ability of DPPH free radical and is substantially better than vitamin C and vitamin E.
The measurement result of ultra-oxygen anion free radical ability removed by table 2
Note: compare with vitamin C,*P ＜ 0.05,**P ＜ 0.01；Compare with vitamin E,△P ＜ 0.05,△△P ＜ 0.01.
Result shows: the present invention removes the ability of ultra-oxygen anion free radical and is substantially better than vitamin C and vitamin E.
The measurement result of table 3 scavenging hydroxyl ability
Result shows: the ability of scavenging hydroxyl of the present invention is substantially better than vitamin C and vitamin E.
Knowable to the mechanism of skin aging, skin aging and internal antioxidative functional weaken, free radical increases relevant.Freely
Skin can be caused damage by base from many aspects, thus accelerates the aging of skin, and therefore, whether anti-aging product has defying age
Removing, the inhibition of free radical can be judged by effect by it.Free radical of a great variety, anti-aging product should have comprehensively
Remove the effect of free radical.From table 1, table 2, table 3, anti-apolexis composition described in embodiment of the present invention 2-5 is respectively provided with stronger
Removing free radical and oxidation resistance.
Experimental example 2 human body skin irritation test
Test objective: the safety to anti-apolexis composition of the present invention detects.
Test method: use the closed patch test of 48h.Weigh embodiment of the present invention 2-5 anti-apolexis composition respectively dilute
Release aqueous solution 0.020mL in speckle reagent as experimental group, blank group is set simultaneously.Choose healthy volunteer 40, year
Age 18-30, without allergies.Behind cleaning experimenter back, the speckle added with anti-apolexis composition of the present invention is tried the non-stimulated glue of device
Band is pasted on back select location, gently presses with finger and be allowed to uniformly be affixed on skin after pasting, and continues 48h.Enjoin tested
Patch position is kept in person 48h to be dried, it is to avoid vigorous exercise, to scratch and grab speckle examination position, long-time sun exposure etc..Remove after 48h
Examination device also carries out labelling, waits impression to disappear under sufficient light and judges, and carry out back in 72h and 96h respectively after 30min
Visit and observe.
Table 4 skin adverse reaction grade scale
Experimental result:
Table 5 present invention zest to skin
Result shows, 40 example experimenters are negative reaction, and the prompting present composition does not has untoward reaction.
Experimental example 3 senile-resistant efficacy evaluation test
Test objective: for verifying the senile-resistant efficacy of this invention anti-apolexis composition, carry out human trial.
Test apparatus: spectrophotometer SpectronicGENESYS-5, skin elasticity tester Cutometer MPA.
Test principle: choosing healthy volunteer 40, age 25-40, without allergies.
Preparing before test: experimenter is randomly divided into 4 groups, often group experimenter's left arm smears the interpolation embodiment of the present invention respectively
2-5 anti-senile preparation, right forearm is smeared the frost without anti-ageing composition, is used as comparison.
Smearing method: experimenter uses the present composition 30 days continuously, is applied to the left forearm crook of the arm after sooner or later washing one's face and rinsing one's mouth every day
Place.Applying amount is to be slightly shown in smear layer.Smear the frost without anti-ageing composition at the right forearm crook of the arm, use as comparison.
Test position: smear specimen locations, follow-on test 6 times at experimenter's left and right forearm crook of the arm, average.
Testing time: use first 1 day of tested products (being designated as 0 day), and using 10 days, 20 days continuously, survey after 30 days
Scale skin renewal rate, skin elasticity.
Method of testing:
Skin elasticity measures: labeled test position, probe vertical is gently pressed on tested skin surface and tests.Elastic ginseng
Number uses ratio, returns to the ability of original position after representing skin deformation.Ratio is closer to 1, and skin elasticity is the best.R2: nothing
The ratio of the springback capacity of skin and maximum tension amount when having a negative pressure, skin in the first time cyclic process of R5: skin test during negative pressure
The ratio that the elastic part of skin recovery process and the elastic adding negative pressure process are divided, in the first time cyclic process of R7: skin test
The elastic part of skin recovery process and the ratio of the maximum tension amount of skin in current cyclic process.
Result of the test:
Skin elasticity measurement result: 4 groups of experimenters use interpolation embodiment of the present invention 2-5 anti-apolexis composition respectively, all
Untoward reaction do not occur, result of the test is as follows:
After table 6 uses the anti-ageing frost different time adding embodiment 2 anti-senile preparation, skin elasticity compares
Note: compare before using,*P ＜ 0.5,**P ＜ 0.01
After table 7 uses the anti-ageing frost different time adding embodiment 3 anti-senile preparation, skin elasticity compares
Note: compare before using,*P ＜ 0.5,**P ＜ 0.01
After table 8 uses the anti-ageing frost different time adding embodiment 4 anti-senile preparation, skin elasticity compares
Note: compare before using,*P ＜ 0.5,**P ＜ 0.01
After table 9 uses the anti-ageing frost different time adding embodiment 5 anti-senile preparation, skin elasticity compares
Note: compare before using,*P ＜ 0.5,**P ＜ 0.01
From table 6-9, contrast with before using after using the anti-ageing frost adding embodiment 2-5 anti-apolexis composition, use
After 20 days, R2, R5, R7 value shows the increase of the significance difference opposite sex, shows to use and adds the anti-ageing of embodiment 2-5 anti-apolexis composition
After frost, skin elasticity has clear improvement.
Experimental example 1 and 2 all confirms that embodiment of the present invention 2-5 compositions has good non-oxidizability and slow down aging is made
With.
Claims (10)
1. a defying age new cosmetic compositions, it is characterised in that: said composition in parts by weight, forms as follows: coffee
Acid phenethyl ester 1～30 parts, propylene glycol 1～30 parts, glycerol 1～20 parts, 1,3 butylene glycol 1～10 parts, 1,2-pentanediol 1～20
Part, the different monooctyl ester of ferulic acid 1～30 parts, HANSHENGJIAO 1～2 parts, hyaluronate sodium 0.1～0.5g part, disodiumedetate 0.1
～1.5 parts, emulsifying agent 30～60 parts, cetearyl alcohol 10～30 parts, polymethyl siloxane 5～30 parts, vegetable oil 30～60 parts,
Freshener 1～20 parts, VB55～10 parts, preservative 2～10 parts, essence 1～5 parts, surplus is deionized water.
A kind of defying age new cosmetic compositions, it is characterised in that: said composition is with weight portion
Meter, forms as follows: CAPE 15 parts, propylene glycol 15 parts, glycerol 10 parts, 1,3 butylene glycol 5 parts, 1,2-pentanediol 10
Part, the different monooctyl ester of ferulic acid 15 parts, HANSHENGJIAO 1.5 parts, hyaluronate sodium 0.3g part, disodiumedetate 0.8 part, emulsifying agent
45 parts, cetearyl alcohol 20 parts, polymethyl siloxane 20 parts, vegetable oil 45 parts, freshener 10 parts, VB58 parts, preservative 6 parts,
3 parts of essence, surplus is deionized water.
A kind of defying age new cosmetic compositions, it is characterised in that: described CAPE
Weight ratio is 1g～30g/1000g.
A kind of defying age new cosmetic compositions, it is characterised in that: described emulsifying agent is PEG-
100 stearates, peregal 0 mixture.
A kind of defying age new cosmetic compositions, it is characterised in that: described vegetable oil is sweet Fructus Pruni
Core oil, American Avocado Tree oil, the mixture of shea butter.
A kind of defying age new cosmetic compositions, it is characterised in that: described vegetable oil is with weight
Part meter, consists of Semen pruni armeniacae oil 3～8 parts, American Avocado Tree oil 3～6 parts, shea butter 1～5 parts.
A kind of defying age new cosmetic compositions, it is characterised in that: described freshener is Herba Menthae
Alcohol.
A kind of defying age new cosmetic compositions, it is characterised in that: described preservative is benzene oxygen
Ethanol.
9. preparing a preparation method for the arbitrary described defying age new cosmetic compositions of claim 1～8, its feature exists
In, comprise the steps:
A) emulsifying agent, cetearyl alcohol, vegetable oil, polymethyl siloxane, HANSHENGJIAO, the different monooctyl ester of ferulic acid are put into oil phase pot,
It is heated to 70～85 DEG C, heat preservation for standby use after waiting all components to dissolve；
B) above-mentioned glycerol, hyaluronate sodium, disodiumedetate, deionized water are put into emulsifying pot, be heated to 70～85
DEG C, it is incubated 15～30 minutes；
C) by CAPE, glycerol, propylene glycol, 1,2-pentanediol, 1,3 butylene glycol puts into oil phase pot, is heated to 70～85
DEG C, heat preservation for standby use until completely dissolved；
D) by the emulsifying pot of the oil phase suction step b) in step a) and step c), with stir speed (S.S.) for 3000rpm stirring 3～
After 5 minutes, then stir 15～45 minutes with stir speed (S.S.) for 30rpm；
E) emulsion in step d) is cooled to 50～55 DEG C, adds above-mentioned VB5, freshener, preservative, essence, stir.
A kind of preparation method of defying age new cosmetic compositions, it is characterised in that: include
Following steps:
A) emulsifying agent, cetearyl alcohol, vegetable oil, polymethyl siloxane, HANSHENGJIAO, the different monooctyl ester of ferulic acid are put into oil phase pot,
It is heated to 80 DEG C, heat preservation for standby use after waiting all components to dissolve；
B) above-mentioned glycerol, hyaluronate sodium, disodiumedetate, deionized water are put into emulsifying pot, be heated to 80 DEG C, protect
Temperature 20 minutes；
C) by CAPE, glycerol, propylene glycol, 1,2-pentanediol, 1,3 butylene glycol puts into oil phase pot, is heated to 78 DEG C,
Heat preservation for standby use until completely dissolved；
D) by the emulsifying pot of the oil phase suction step b) in step a) and step c), 4 points are stirred with stir speed (S.S.) for 3000rpm
Zhong Hou, then stir 30 minutes with stir speed (S.S.) for 30rpm；
E) emulsion in step d) is cooled to 50～55 DEG C, adds above-mentioned VB5, freshener, preservative, essence, stir.
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Cited By (2)
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|---|---|---|---|---|
| CN112137939A (en) * | 2020-11-10 | 2020-12-29 | 上海辉文生物技术股份有限公司 | Composition with functions of reducing fine lines and increasing skin elasticity, preparation method and application thereof |
| US11992549B2 (en) | 2018-09-27 | 2024-05-28 | Wacker Chemie Ag | Oil-in-water emulsion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434684A (en) * | 2014-12-10 | 2015-03-25 | 上海新高姿化妆品有限公司 | Regenerated whitening cream containing plant extracts and preparation method of regenerated whitening cream |
| KR20150066805A (en) * | 2013-12-09 | 2015-06-17 | 주식회사 엘지생활건강 | Cosmetics Compositions for antioxidant |
-
2016
- 2016-06-20 CN CN201610490027.2A patent/CN106109270B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150066805A (en) * | 2013-12-09 | 2015-06-17 | 주식회사 엘지생활건강 | Cosmetics Compositions for antioxidant |
| CN104434684A (en) * | 2014-12-10 | 2015-03-25 | 上海新高姿化妆品有限公司 | Regenerated whitening cream containing plant extracts and preparation method of regenerated whitening cream |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11992549B2 (en) | 2018-09-27 | 2024-05-28 | Wacker Chemie Ag | Oil-in-water emulsion |
| CN112137939A (en) * | 2020-11-10 | 2020-12-29 | 上海辉文生物技术股份有限公司 | Composition with functions of reducing fine lines and increasing skin elasticity, preparation method and application thereof |
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