CN106103715A - 沙门氏菌的非编码性rna及其鉴定和应用 - Google Patents

沙门氏菌的非编码性rna及其鉴定和应用 Download PDF

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CN106103715A
CN106103715A CN201480067482.0A CN201480067482A CN106103715A CN 106103715 A CN106103715 A CN 106103715A CN 201480067482 A CN201480067482 A CN 201480067482A CN 106103715 A CN106103715 A CN 106103715A
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milrna
salmonella
sal
expression
infection
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CN106103715B (zh
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曾科
顾宏伟
张辰宇
张天赋
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Jiangsu Micromedmark Biotech Co Ltd
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Abstract

提供了沙门氏菌的非编码性RNA及其鉴定和应用。具体地，沙门氏菌将自身编码的非编码RNA(ncRNA)呈递到宿主细胞内，借助细胞的microRNA剪切系统，产生出类似microRNA的milRNA，运用milRNA调控免疫系统，保护沙门氏菌免于被宿主清除。利用milRNA的抑制剂吸附milRNA可有效抑制细菌在细胞内的存活能力，导致细菌生存能力下降。还提供了可有效检测、治疗和研究沙门氏菌或感染疾病的相关试剂和方法。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201480067482.0A 2013-12-09 2014-12-09 沙门氏菌的非编码性rna及其鉴定和应用 Active CN106103715B (zh)

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CN2013106655657 2013-12-09
CN201310665565.7A CN104694533A (zh) 2013-12-09 2013-12-09 沙门氏菌的非编码性rna及其鉴定和应用
PCT/CN2014/093385 WO2015085905A1 (zh) 2013-12-09 2014-12-09 沙门氏菌的非编码性rna及其鉴定和应用

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CN109576271A (zh) * 2018-03-02 2019-04-05 中国热带农业科学院环境与植物保护研究所 一种香蕉枯萎菌milRNA

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US9938558B2 (en) 2015-06-25 2018-04-10 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
WO2018126026A1 (en) 2016-12-28 2018-07-05 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing complete microorganism strains in complex heterogeneous communities, determining functional relationships and interactions thereof, and identifying and synthesizing bioreactive modificators based thereon
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CN105624160B (zh) * 2015-12-24 2018-09-14 中国人民武装警察部队总医院 布鲁氏菌的非编码小RNA分子ncRNA1351及其应用
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MX2019007760A (es) 2016-12-28 2020-02-10 Ascus Biosciences Inc Metodos, aparatos y sistemas para analisis de cepa de microorganismo de comunidades heterogeneas complejas con analisis rastreador, determinacion de relaciones funcionales e interacciones de estas, y sintesis de agrupaciones microbianas que incluyen agrupaciones microbianas dosificadas y agrupaciones microbianas inoculativas.
MX2019012680A (es) 2017-04-28 2019-12-11 Ascus Biosciences Inc Metodos para complementar dietas con alto consumo de granos y/o alto valor energetico en rumiantes, mediante la administracion de un bioensamble sintetico de microbios, o cepas purificadas de los mismos.
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CN110004234B (zh) * 2019-04-19 2023-03-28 中国农业科学院北京畜牧兽医研究所 鸡抗沙门氏菌感染相关的miRNA及其应用
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EP3081646A1 (en) 2016-10-19
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CN104694533A (zh) 2015-06-10
CN106103715B (zh) 2020-01-07
US20160319332A1 (en) 2016-11-03
EP3081646A4 (en) 2016-12-14
US9903002B2 (en) 2018-02-27
JP6280222B2 (ja) 2018-02-14
KR20160097297A (ko) 2016-08-17
WO2015085905A1 (zh) 2015-06-18
KR101927726B1 (ko) 2018-12-11

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