CN106075500A - 一种用于b超室器械的杀菌剂及其制备方法 - Google Patents
一种用于b超室器械的杀菌剂及其制备方法 Download PDFInfo
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Abstract
本发明属于医用消毒剂技术领域，公开了一种用于B超室器械的杀菌剂，其按照如下步骤制备而得：步骤1）混合搅拌，步骤2）搅拌和静置，步骤3）搅拌均匀，步骤4）加热和搅拌，步骤5）乙醇提取和浓缩粉碎，步骤6）搅拌、分装以及密封。本发明制备的消毒剂性能稳定、制备工艺简单。
Description
技术领域
本发明属于医用消毒剂技术领域，具体涉及一种用于B超室器械的杀菌剂及其制备方法。
背景技术
B超声是医院常规的诊断方法。B超可以清晰地显示各脏器及周围器官的各种断面像，由于图像富于实体感，接近于解剖的真实结构，所以应用超声可以早期明确诊断。超声诊断仪有各种档次，先进的高档仪器结构复杂，具有高性能、多功能、高分辨率和高清晰度等特点。它们的基本构件包括发射、扫查、接收、信号处理和显示等五个组成部分，分为两大部件，即主机和探头。一个主机可以有一个、两个或更多的探头，而一个探头内可以安装1个或数十个以至千个以上晶片，如实时超声诊断探头，由1至数个晶片组成一个阵元，依次轮流工作、发射和接收声能。晶片由电致伸缩材料构成，担任电、声或声、电的能量转换，故也称为换能器。按频率有单频、多频和宽频探头。实时超声探头按压电晶片的排列分线阵、环阵、凸阵等，按用途又有体表、腔内、管内各种名称，有的探头仅数毫米，可进入冠状动脉内。
目前医用耦合剂和医院超声探头带菌状况令人堪优。医院使用中的超声探头普遍不作消毒处理，检查之后只使用白色棉纸进行擦拭，然后即进行下一个检查，且医用超声探头频繁接触健康体检者、传染病患者、皮肤病患者、婴幼儿、孕妇等不同人群，在临床检查中探头往往会携带多种致病微生物，存在医源性交叉感染的潜在危险，导致超声探头带菌率严重。目前，市场上已开始有消毒杀菌型超声耦合剂出售，但这些耦合剂存在杀菌剂效果不佳、成分之间配伍不合理、容易对仪器腐蚀以及损害耦合剂本身功能等诸多问题。现有技术需要一种用于B超室器械的杀菌剂及其制备方法。
发明内容
本发明的目的是克服现有技术的不足而提供一种用于B超室器械的杀菌剂及其制备方法，该消毒剂抗菌杀毒作用强，稳定性高，制备工艺简单可行。
本发明是通过如下技术方案来实现的：
一种用于B超室器械的杀菌剂，其按照如下步骤制备而得：
步骤1）混合搅拌：将乙醇、邻苯基苯酚、甘油以及二氯苯氧氯酚按照4:1:9:3的质量比混合，300转/min搅拌10min，得到混合料A；
步骤2）搅拌和静置：将对羟基苯甲酸甲酯加入步骤1）所得混合液A中，500转/min搅拌3min，静置15min，得到混合液B；其中，对羟基苯甲酸甲酯、混合料A的质量比为1:30；
步骤3）搅拌均匀：将十二烷基硫酸钠和维生素E依次添加到去离子水中，搅拌均匀，得到混合料C；其中，十二烷基硫酸钠、维生素E以及去离子水的质量比为3:2:300；
步骤4）加热和搅拌：将步骤2）所得混合液C加热至50℃，边搅拌边加入五氯酚钠以及羟基氯化铝，得到混合料D；其中，五氯酚钠、羟基氯化铝以及混合液C的质量比为2:1:50；
步骤5）乙醇提取和浓缩粉碎：将金银花和黑胡椒按照1:1的质量比混合，添加占混合物两倍重量85%（体积比）的乙醇，回流提取2次，每次1小时，提取液合并，浓缩至密度为1.1g/ml的浸膏，60℃干燥后，粉碎，过100目筛，即得混合料E；
步骤6）搅拌、分装以及密封：将混合料B、混合料E依次添加到混合料D中，300转/min搅拌 0.5小时，分装、密封即得；其中，混合料B、混合料E以及混合料D的质量比为40-65:3-4:100-130。
本发明还公开了上述杀菌剂的制备方法。
本发明取得的有益效果主要包括：
本发明的杀菌剂可应用于B超室器械消毒杀菌，包括B超机表面、探头以及桌椅床等；本发明的消毒剂安全有效，能有效杀灭医院常见的金黄色葡萄球菌、痢疾杆菌和大肠杆菌等细菌，效果高，杀菌时间短；本发明消毒剂对金属器材无腐蚀，容易擦掉；本发明消毒剂各理化指标性能稳定，在使用期间未见结晶、浑浊、沉淀，各项理化指标表现稳定；本发明制备消毒剂生产成本低、制备工艺简单、工艺条件易于实现；本发明采用化学消毒剂和植物提取物杀菌剂相结合的方式，减少了化学消毒剂的用量，配伍协同效果好；本发明植物原料在当地容易获得，成本低廉，杀菌效果好。
具体实施方式
为了使本技术领域的人员更好地理解本申请中的技术方案，下面将结合本申请具体实施例，对本发明进行更加清楚、完整地描述，显然，所描述的实施例仅仅是本申请一部分实施例，而不是全部的实施例。基于本申请中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都应当属于本发明保护的范围。
实施例1
一种用于B超室器械的杀菌剂，其按照如下步骤制备而得：
步骤1）混合搅拌：将乙醇、邻苯基苯酚、甘油以及二氯苯氧氯酚按照4:1:9:3混合，300转/min搅拌10min，得到混合料A；
步骤2）搅拌和静置：将对羟基苯甲酸甲酯加入步骤1）所得混合液A中，500转/min搅拌3min，静置15min，得到混合液B；其中，对羟基苯甲酸甲酯、混合料A的质量比为1:30；
步骤3）搅拌均匀：将十二烷基硫酸钠和维生素E依次添加到去离子水中，搅拌均匀，得到混合料C；其中，十二烷基硫酸钠、维生素E以及去离子水的质量比为3:2:300；
步骤4）加热和搅拌：将步骤2）所得混合液C加热至50℃，边搅拌边加入五氯酚钠以及羟基氯化铝，得到混合料D；其中，五氯酚钠、羟基氯化铝以及混合液C的质量比为2:1:50；
步骤5）乙醇提取和浓缩粉碎：将金银花和黑胡椒按照1:1的质量比混合，添加占混合物两倍重量85%（体积比）的乙醇，回流提取2次，每次1小时，提取液合并，浓缩至密度为1.1g/ml的浸膏，60℃干燥后，粉碎，过100目筛，即得混合料E；
步骤6）搅拌、分装以及密封：将混合料B、混合料E依次添加到混合料D中，300转/min搅拌 0.5小时，分装、密封即得；其中，混合料B、混合料E以及混合料D的质量比为40:3:100。
实施例2
一种用于B超室器械的杀菌剂，其按照如下步骤制备而得：
步骤1）混合搅拌：将乙醇、邻苯基苯酚、甘油以及二氯苯氧氯酚按照4:1:9:3混合，300转/min搅拌10min，得到混合料A；
步骤2）搅拌和静置：将对羟基苯甲酸甲酯加入步骤1）所得混合液A中，500转/min搅拌3min，静置15min，得到混合液B；其中，对羟基苯甲酸甲酯、混合料A的质量比为1:30；
步骤3）搅拌均匀：将十二烷基硫酸钠和维生素E依次添加到去离子水中，搅拌均匀，得到混合料C；其中，十二烷基硫酸钠、维生素E以及去离子水的质量比为3:2:300；
步骤4）加热和搅拌：将步骤2）所得混合液C加热至50℃，边搅拌边加入五氯酚钠以及羟基氯化铝，得到混合料D；其中，五氯酚钠、羟基氯化铝以及混合液C的质量比为2:1:50；
步骤5）乙醇提取和浓缩粉碎：将金银花和黑胡椒按照1:1的质量比混合，添加占混合物两倍重量85%（体积比）的乙醇，回流提取2次，每次1小时，提取液合并，浓缩至密度为1.1g/ml的浸膏，60℃干燥后，粉碎，过100目筛，即得混合料E；
步骤6）搅拌、分装以及密封：将混合料B、混合料E依次添加到混合料D中，300转/min搅拌 0.5小时，分装、密封即得；其中，混合料B、混合料E以及混合料D的质量比为65:4:130。
实施例3
抑菌试验如下：
实验菌种：金黄色葡萄球菌、大肠杆菌、痢疾杆菌、肺炎球菌。
实验流程：将四种菌种分别接种到营养肉汤培养基中，30℃培养24小时，分离菌液，稀释成1×108个/ml，然后将四种菌液混合，得到混合菌液，然后取10ml混合菌液置于20个培养皿中，其中对照组（10个）和试验组（10个），采用实施例1的消毒剂）；将本发明消毒液稀释液（稀释10倍）分别滴入测试组培养皿，市售84消毒液稀释液（稀释10倍）分别滴入对照组培养皿；滴加量为1ml/个培养皿；分别检测了30min和60min各菌种菌落残留面积结果，见表1-2：
表1
| 菌落残留面积（30min） | 金黄色葡萄球菌 | 大肠杆菌 | 痢疾杆菌 | 肺炎球菌 |
| 对照组% | 23.1 | 22.4 | 29.6 | 20.6 |
| 试验组% | 3.5 | 3.7 | 4.3 | 2.4 |
表2
| 菌落残留面积（60min） | 金黄色葡萄球菌 | 大肠杆菌 | 痢疾杆菌 | 肺炎球菌 |
| 对照组% | 13.5 | 14.1 | 16.8 | 12.3 |
| 试验组% | 1.5 | 1.4 | 2.2 | 1.1 |
稳定性试验：37℃下存放半年，外观未见结晶、浑浊、沉淀，杀菌效果下降1%左右，稳定性较好，符合相关规定。
最后，还需要注意的是，以上列举的仅是本发明的若干个具体实施例。显然，本发明不限于以上实施例，还可以有许多变形。本领域的普通技术人员能从本发明公开的内容直接导出或联想到的所有变形，均应认为是本发明的保护范围。
Claims (3)
1.一种用于B超室器械的杀菌剂，其按照如下步骤制备而得：步骤1）混合搅拌，步骤2）搅拌和静置，步骤3）搅拌均匀，步骤4）加热和搅拌，步骤5）乙醇提取和浓缩粉碎，步骤6）搅拌、分装以及密封。
2.根据权利要求1所述的杀菌剂，其特征在于，所述杀菌剂按照如下步骤制备而得：
步骤1）混合搅拌：将乙醇、邻苯基苯酚、甘油以及二氯苯氧氯酚按照4:1:9:3的质量比混合，300转/min搅拌10min，得到混合料A；
步骤2）搅拌和静置：将对羟基苯甲酸甲酯加入步骤1）所得混合液A中，500转/min搅拌3min，静置15min，得到混合液B；其中，对羟基苯甲酸甲酯、混合料A的质量比为1:30；
步骤3）搅拌均匀：将十二烷基硫酸钠和维生素E依次添加到去离子水中，搅拌均匀，得到混合料C；其中，十二烷基硫酸钠、维生素E以及去离子水的质量比为3:2:300；
步骤4）加热和搅拌：将步骤2）所得混合液C加热至50℃，边搅拌边加入五氯酚钠以及羟基氯化铝，得到混合料D；其中，五氯酚钠、羟基氯化铝以及混合液C的质量比为2:1:50；
步骤5）乙醇提取和浓缩粉碎：将金银花和黑胡椒按照1:1的质量比混合，添加占混合物两倍重量85%（体积比）的乙醇，回流提取2次，每次1小时，提取液合并，浓缩至密度为1.1g/ml的浸膏，60℃干燥后，粉碎，过100目筛，即得混合料E；
步骤6）搅拌、分装以及密封：将混合料B、混合料E依次添加到混合料D中，300转/min搅拌 0.5小时，分装、密封即得；其中，混合料B、混合料E以及混合料D的质量比为40-65:3-4:100-130。
3.权利要求1-2所述杀菌剂的用途。
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2875436Y (zh) * | 2005-12-29 | 2007-03-07 | 刘敏鹃 | 体温计消毒内盒 |
| CN101507824A (zh) * | 2008-03-12 | 2009-08-19 | 北京绿岛缘蜂产品有限公司 | 一种高效杀菌衣物消毒剂 |
| CN104474566A (zh) * | 2014-12-12 | 2015-04-01 | 杨玉芳 | 一种检验科检验器具的消毒装置及消毒液 |
| WO2015164519A1 (en) * | 2014-04-22 | 2015-10-29 | Gregory John Dobbyn | System and method for probe cleaning and disinfecting |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2875436Y (zh) * | 2005-12-29 | 2007-03-07 | 刘敏鹃 | 体温计消毒内盒 |
| CN101507824A (zh) * | 2008-03-12 | 2009-08-19 | 北京绿岛缘蜂产品有限公司 | 一种高效杀菌衣物消毒剂 |
| WO2015164519A1 (en) * | 2014-04-22 | 2015-10-29 | Gregory John Dobbyn | System and method for probe cleaning and disinfecting |
| CN104474566A (zh) * | 2014-12-12 | 2015-04-01 | 杨玉芳 | 一种检验科检验器具的消毒装置及消毒液 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018223080A1 (en) * | 2017-06-02 | 2018-12-06 | Zurex Pharma, Inc. | Low-alcohol and sterilizable antimicrobial compositions and use thereof |
| IL270898B (en) * | 2017-06-02 | 2022-12-01 | Zurex Pharma Inc | Antibacterial preparations with a low amount of alcohol that can be disinfected and their uses |
| IL270898B2 (en) * | 2017-06-02 | 2023-04-01 | Zurex Pharma Inc | Antibacterial preparations with a low amount of alcohol that can be disinfected and their uses |
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