CN106075077A - A kind of preparation method treating prosopalgic Chinese medicine composition and preparation thereof - Google Patents

A kind of preparation method treating prosopalgic Chinese medicine composition and preparation thereof Download PDF

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CN106075077A
CN106075077A CN201610686866.1A CN201610686866A CN106075077A CN 106075077 A CN106075077 A CN 106075077A CN 201610686866 A CN201610686866 A CN 201610686866A CN 106075077 A CN106075077 A CN 106075077A
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孙丰卿
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Abstract

One treats prosopalgic Chinese medicine composition, is made up of 46 parts of Herba Ephedrae, Scorpio 5 15 parts, Rhizoma Chuanxiong 15 25 parts, Radix Angelicae Sinensis 15 25 parts, Rhizoma Cimicifugae 5 15 parts, Concha Haliotidis 15 25 parts, Caulis Polygoni Multiflori 25 35 parts, Bombyx Batryticatus 10 20 parts, Folium Lauri nobilis 57 parts, 5 15 parts of Cornu Bovis seu Bubali powder, Pseudobulbus Cremastrae Seu Pleiones 5 15 parts, 0.15 0.45 parts of Moschus.Dosage form is water decoction, tablet, granule, pill, capsule or powder.There is medication instant effect, the feature having no side effect.Cure rate can be significantly improved.Therapeutic effect is obvious.

Description

A kind of preparation method treating prosopalgic Chinese medicine composition and preparation thereof
Technical field
The present invention relates to a kind of preparation method treating prosopalgic Chinese medicine composition and preparation thereof, belong to Chinese medicine Field.
Background technology
Trigeminal neuralgia is modal cranial nerve diseases, with the battle array of recurrent exerbation in face nervi trigeminus areal area, side The property sent out acutely pain is main performance, the sickness rate 52.2/10 ten thousand of domestic statistics, and female slightly more than man, sickness rate can increase with the age Long.The multiple middle-aged and elderly people of being born in of trigeminal neuralgia, R)L.The feature of this disease is: be distributed at Head And Face nervi trigeminus In region, morbidity is rapid to be sent out, and all standing, lightning sample, the sample that lancinates, burns sample, intractable, insufferable severity pain.Speak, wash Face, brush teeth or mild wind strokes face, having an intense pain when all can cause paroxysmal time the most on foot.Pain lasts several seconds or several minutes, Pain is periodical attack, and the outbreak intermission is the same with normal person.Trigeminal neuralgia is divided into constitutional and Secondary cases two kinds, secondary Property trigeminal neuralgia include brain occupying lesion and perstriction, the cause of disease of primary trigeminal neuralgia and pathogenesis, west Doctor there is no clear and definite final conclusion so far, and the traditional Chinese medical science is thought and belonged to Liver and kidney problem.Age is many more than 40 years old, with in, old the most. Women be more than male, about 3: 2.Prosopalgic outbreak is often without omen, and panic attacks is the most regular.Pain is sent out every time Make time only last for several seconds suddenly to stop to several minutes.During initial stage onset, attack times is less, and the intermission is the longest, several minutes, number Hour, with PD, outbreak is gradually frequent, and the intermission is gradually shortened, and pain the most gradually increases the weight of and violent.Night pain Outbreak reduces.Risk factor: speak, have a meal, wash one's face, shave, brush teeth and wind etc. all can induce panic attacks, so that patient Lethargy is depressed, takes action overcautious, even dare not wash one's face, brushes teeth, take food, and speaks also careful, lest cause outbreak.
Primary disease can carry out operative treatment, chemotherapy first-selection carbamazepine, and the patient's pain relieving to 70% is effective, benzene Appropriate English sodium curative effect is not so good as carbamazepine.At present, the most do not treat prosopalgic Chinese medicinal composition preparation and Chinese patent medicine, The many less effective of clinical practice treatment by Chinese herbs.
Summary of the invention
For above not enough, the present invention provides a kind of effect significantly to treat prosopalgic Chinese medicine composition and system thereof The preparation method of agent.
Technical scheme is as follows:
One treats prosopalgic Chinese medicine composition, and described Chinese medicine composition is made up of the raw material of following weight portion:
Herba Ephedrae 4-6 part, Scorpio 5-15 part, Rhizoma Chuanxiong 15-25 part, Radix Angelicae Sinensis 15-25 part, Rhizoma Cimicifugae 5-15 part, Concha Haliotidis 15-25 part, night Hand over rattan 25-35 part, Bombyx Batryticatus 10-20 part, Folium Lauri nobilis 5-7 part, Cornu Bovis seu Bubali 5-15 part, Pseudobulbus Cremastrae Seu Pleiones 5-15 part, Moschus 0.15-0.45 Part.
Further preferred as technique scheme, described Chinese medicine composition is made up of the raw material of following weight portion:
5 parts of Herba Ephedrae, Scorpio 10 parts, Rhizoma Chuanxiong 20 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Cimicifugae 10 parts, Concha Haliotidis 20 parts, Caulis Polygoni Multiflori 30 parts, Bombyx Batryticatus 15 Part, Folium Lauri nobilis 6 parts, Cornu Bovis seu Bubali 10 parts, Pseudobulbus Cremastrae Seu Pleiones 10 parts, 0.3 part of Moschus.
A kind of preparation method treating prosopalgic Chinese medicine composition pharmaceutical preparation, comprises the following steps:
A, take each composition according to above ratio;
B, Concha Haliotidis, Moschus, Cornu Bovis seu Bubali are pulverized 100 mesh respectively, obtain Concha Haliotidis powder, Moschus powder, Cornu Bovis seu Bubali powder;
C, by Herba Ephedrae, Scorpio, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cimicifugae, Caulis Polygoni Multiflori, Bombyx Batryticatus, Folium Lauri nobilis and Pseudobulbus Cremastrae Seu Pleiones co-grinding, add 6 times of volumes 75% alcohol reflux 1-2 hour, filter, take filtrate, filtrate repeats reflux, extract, 2-3 time, merging filtrate, the stone of addition step b Semen Cassiae powder, Moschus powder, Cornu Bovis seu Bubali powder, concentrate refining to relative density 70 DEG C and be measured as the thick paste agent of 1.38, obtain unguentum, second after mixing Alcohol reclaims;
D, step c gained unguentum is moved into baking box, dries to moisture less than 5%, take out and pulverize, obtain drug powder;
E, by step d gained drug powder add be suitable for adjuvant, make tablet, granule, pill, decocting by prior art Agent, capsule or powder.
The Chinese medicine composition pharmaceutical preparation of the present invention is one of following dosage forms: water decoction, tablet, granule, pill, capsule or Powder, is all made by prior art processes.
In above raw material,
Cornu Bovis seu Bubali: for the angle of bovid cattle.Effect: cooling blood for hemostasis, heat-clearing and toxic substances removing.For the haematemesis of bleeding due to blood-heat, Epistaxis, ulcerative carbuncle furuncle and phyma.Meridian distribution of property and flavor: bitter, salty, cold.The heart, liver, stomach three warp.
Pseudobulbus Cremastrae Seu Pleiones function cures mainly: eliminating stagnation, blood stasis dispelling.Controlling laryngopharynx swelling and pain, scrofula, carbuncle, skin ulcer swells, and puerperal, the stasis of blood was stagnant.
Folium Lauri nobilis function cures mainly: stomach invigorating is regulated the flow of vital energy.Stomachache that main gastral cavity is swollen;Injury from falling down;Scabies.Scorpio function cures mainly: endogenous wind stopping town Convulsion, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Control infantile convulsion to take out and pluck, epilepsy, apoplexy, hemiplegia, facial hemiparalysis, migraine, rheumatic arthralgia, Tetanus, tuberculous lymphadenitis, rubella skin ulcer swells, skin infection, scrofula.
The attending effectiveness of Rhizoma Chuanxiong: have effect of blood-activating and qi-promoting, wind-expelling pain-stopping.Menoxenia such as menstruation for stagnation of QI and blood Rear time limit, dysmenorrhea, amenorrhea, have the effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, can be used for again experiencing headache that ailment said due to cold or exposure (flu) causes, General pain and rheumatic arthralgia etc..Therefore front person " gas medicine in blood ".The attending effectiveness of Radix Angelicae Sinensis: replenishing and activating blood, menstruction regulating and pain relieving, intestine moistening are led to Just.For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhoea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, fall and flutter damage Wound, ulcer sores.
The attending effectiveness of Bombyx Batryticatus: expelling wind and relieving convulsion, dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat.Main infantile convulsion is twitched;Middle air port eye is oblique;
Migraine and general headache;Laryngopharynx swelling and pain;Scrofula;Mumps;Rubella.
The attending effectiveness of Herba Ephedrae: relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chest breath with cough, edema due to wind pathogen Edema;Bronchial asthma.
The attending effectiveness of Rhizoma Cimicifugae: deliver rash, heat-clearing and toxic substances removing, rise and lift yang-energy.Primary treatment: headache due to pathogenic wind-heat, measles without adequate eruption. Toothache aphtha, laryngopharynx swelling and pain, collapse of QI, chronic diarrhea proctoptosis.
The attending effectiveness of Caulis Polygoni Multiflori: nourish heart, calms the nerves, and dredging collateral dispels the wind.Cure mainly insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle Cellulitis, scrofula, wind skin ulcer scabies.
The attending effectiveness of Concha Haliotidis: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.For dizziness of having a headache, cataract, blurring of vision, green grass or young crops Blind nyctalopia.Control wind-yang and up-boring, headache, dizziness, shy and jerk, hectic fever due to YIN-deficiency consumptive fever, optic atrophy.
The attending effectiveness of Moschus: refreshment of having one's ideas straightened out;Blood circulation promoting and dispersing pathogen accumulation;Alleviating pain and detumescence.Main calentura kills dusk;Apoplexy syncope due to accumulation of phlegm;The stagnation of QI is sudden and violent Faint;Attacked by pestiferous factors is gone into a coma;Blood stasis amenorrhea;Lump in the abdomen;Trusted subordinate's shoot;Traumatic injury;Arthralgia pain is numb;Carbuncle malignant boil;Sore throat;Aphtha; Ulcerative gingivitis;Glue ear.For calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors stupor, amenorrhea, abdominal mass, stillborn fetus of having difficult labour, Xin Fubao Bitterly, carbuncle scrofula, laryngopharynx swelling and pain, fall and flutter the pain of injury, arthralgia pain is numb.
Prosopalgic pathological change shows head, for three YANG meridians distributed areas, is positioned at the top of people, has with ailment said due to cold or exposure Close.Wind rises to be sent out, upwards, on high mountain peak, only wind can and, ailment said due to cold or exposure holds miscellaneous cold-evil under the arm, burning hot, expectorant is turbid, so that wind and cold stagnates, on wind-fire Burn, wind-phlegm blocks meridians.Causing pain, cold, expectorant is interior stops up also easily fire-transformation heat.Caused by internal injury, feelings will is unsuccessful, can cause liver and lose bar Reach, pathogenic fire derived from stagnation of liver-QI, disturbing upward of liver-fire head, meridians of burning, then see head pain;Or because feelings will is unsuccessful, cause qi depression to blood stasis, or due to illness Enter network for a long time, also seen from have the stasis of blood as.
Present invention application Caulis Polygoni Multiflori tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral.Moschus assists Caulis Polygoni Multiflori to have one's ideas straightened out removing obstruction in the collateral to relieve pain.Herba Ephedrae is assisted Caulis Polygoni Multiflori, Moschus induce sweat pain relieving.Concha Haliotidis suppressing the hyperactive liver and subsiding YANG, liver heat removing.Rhizoma Chuanxiong, Radix Angelicae Sinensis blood-activating and qi-promoting.Bombyx Batryticatus, Scorpio are expellingged wind and relieving convulsion, Alleviate face ache.Rhizoma Cimicifugae heat-clearing and toxic substances removing, rises and lifts yang-energy.Folium Lauri nobilis regulating QI to relieve pain, Cornu Bovis seu Bubali heat-clearing and toxic substances removing, removing heat from blood.Pseudobulbus Cremastrae Seu Pleiones Eliminating stagnation, blood stasis dispelling.
The present invention compared with prior art, has the advantage that monarch of the present invention, minister, helps, makes respectively to execute its effect, in can reach Outer and execute, the purpose of giving consideration to both the incidental and fundamental.There is medication instant effect, the feature having no side effect.Cure rate can be significantly improved.Therapeutic effect Substantially, it is worthy of popularization.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1: a kind of treat prosopalgic Chinese medicine composition, is made up of the raw material of following weight portion:
5 parts of Herba Ephedrae, Scorpio 10 parts, Rhizoma Chuanxiong 20 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Cimicifugae 10 parts, Concha Haliotidis 20 parts, Caulis Polygoni Multiflori 30 parts, Bombyx Batryticatus 15 Part, Folium Lauri nobilis 6 parts, Cornu Bovis seu Bubali 10 parts, Pseudobulbus Cremastrae Seu Pleiones 10 parts, 0.3 part of Moschus.
The preparation method of described Chinese medicinal composition preparation, comprises the following steps:
A, take each composition according to above ratio;
B, Concha Haliotidis, Moschus, Cornu Bovis seu Bubali are pulverized 100 mesh respectively, obtain Concha Haliotidis powder, Moschus powder, Cornu Bovis seu Bubali powder;
C, by Herba Ephedrae, Scorpio, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cimicifugae, Caulis Polygoni Multiflori, Bombyx Batryticatus, Folium Lauri nobilis and Pseudobulbus Cremastrae Seu Pleiones co-grinding, add 6 times of volumes 75% alcohol reflux 1-2 hour, filter, take filtrate, filtrate repeats reflux, extract, 2-3 time, merging filtrate, the stone of addition step b Semen Cassiae powder, Moschus powder, Cornu Bovis seu Bubali powder, concentrate refining to relative density 70 DEG C and be measured as the thick paste agent of 1.38, obtain unguentum, second after mixing Alcohol reclaims;
D, step c gained unguentum is moved into baking box, dries to moisture less than 5%, take out and pulverize, obtain drug powder;
E, by step d gained drug powder add be suitable for adjuvant, make powder by prior art.
Embodiment 2: a kind of treat prosopalgic Chinese medicine composition, is made up of the raw material of following weight portion:
6 parts of Herba Ephedrae, Scorpio 15 parts, Rhizoma Chuanxiong 25 parts, Radix Angelicae Sinensis 25 parts, Rhizoma Cimicifugae 15 parts, Concha Haliotidis 25 parts, Caulis Polygoni Multiflori 35 parts, Bombyx Batryticatus 20 Part, Folium Lauri nobilis 7 parts, Cornu Bovis seu Bubali 15 parts, Pseudobulbus Cremastrae Seu Pleiones 15 parts, 0.45 part of Moschus.
Preparation method is with embodiment 1.
Embodiment 3: one treats prosopalgic Chinese medicine composition, is made up of the raw material of following weight portion:
4 parts of Herba Ephedrae, Scorpio 5 parts, Rhizoma Chuanxiong 15 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Cimicifugae 5 parts, Concha Haliotidis 15 parts, Caulis Polygoni Multiflori 25 parts, Bombyx Batryticatus 10 parts, Folium Lauri nobilis 5 parts, Cornu Bovis seu Bubali 5 parts, Pseudobulbus Cremastrae Seu Pleiones 5 parts, 0.15 part of Moschus.
Preparation method is with embodiment 1.
Contrast test: criterion of therapeutical effect: draft with reference to<<disease of tcm Standardization of diagnosis and curative effect>>: cure: panic attacks disappears.Good Turn: pain relief when attack times reduces or shows effect.Invalid: after treatment, symptom is without improving.
Choose 200 example affected nerves of patients with trigeminal neuralgias, randomly select 150 examples as treatment group, other 50 examples as a control group, its In 150 example patients be divided into treatment group 1, treatment group 2 and treatment group 3, each treatment group treats the 50 example patients randomly selected, treatment The powder of the group 1 use embodiment of the present invention 1 preparation is treated, and the powder that treatment group 2 uses the embodiment of the present invention 2 to prepare is carried out Treating, the powder that treatment group 3 uses the embodiment of the present invention 3 to prepare is treated, and each 9g, every day 2 times, 15 days is a course for the treatment of.
The patient of matched group uses Carbamazepine Tablets to treat.
Therapeutic outcome such as following table:
From data above table it can be seen that treatment group effective percentage cure rate is apparently higher than matched group, treatment group 1 and treatment group 2 Cure rate effective percentage is higher than remaining treatment group 3, and treatment group in sum 1 and treatment group 2 prescription are maximally efficient.

Claims (4)

1. treat a prosopalgic Chinese medicine composition, it is characterized in that: described Chinese medicine composition is former by following weight portion Material is made:
Herba Ephedrae 4-6 part, Scorpio 5-15 part, Rhizoma Chuanxiong 15-25 part, Radix Angelicae Sinensis 15-25 part, Rhizoma Cimicifugae 5-15 part, Concha Haliotidis 15-25 part, night Hand over rattan 25-35 part, Bombyx Batryticatus 10-20 part, Folium Lauri nobilis 5-7 part, Cornu Bovis seu Bubali 5-15 part, Pseudobulbus Cremastrae Seu Pleiones 5-15 part, Moschus 0.15-0.45 Part.
2. as claimed in claim 1 treat prosopalgic Chinese medicine composition, it is characterized in that: described Chinese medicine composition by with The raw material of lower weight portion is made:
5 parts of Herba Ephedrae, Scorpio 10 parts, Rhizoma Chuanxiong 20 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Cimicifugae 10 parts, Concha Haliotidis 20 parts, Caulis Polygoni Multiflori 30 parts, Bombyx Batryticatus 15 Part, Folium Lauri nobilis 6 parts, Cornu Bovis seu Bubali 10 parts, Pseudobulbus Cremastrae Seu Pleiones 10 parts, 0.3 part of Moschus.
3. the prosopalgic Chinese medicine composition for the treatment of as claimed in claim 1 or 2, is characterized in that: described Chinese medicine composition The preparation method of preparation comprise the following steps:
A, take each composition according to above ratio;
B, Concha Haliotidis, Moschus, Cornu Bovis seu Bubali are pulverized 100 mesh respectively, obtain Concha Haliotidis powder, Moschus powder, Cornu Bovis seu Bubali powder;
C, by Herba Ephedrae, Scorpio, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cimicifugae, Caulis Polygoni Multiflori, Bombyx Batryticatus, Folium Lauri nobilis and Pseudobulbus Cremastrae Seu Pleiones co-grinding, add 6 times of volumes 75% alcohol reflux 1-2 hour, filter, take filtrate, filtrate repeats reflux, extract, 2-3 time, merging filtrate, the stone of addition step b Semen Cassiae powder, Moschus powder, Cornu Bovis seu Bubali powder, concentrate refining to relative density 70 DEG C and be measured as the thick paste agent of 1.38, obtain unguentum, return after mixing Receive ethanol;
D, step c gained unguentum is moved into baking box, dries to moisture less than 5%, take out and pulverize, obtain drug powder;
E, by step d gained drug powder add be suitable for adjuvant, make tablet, granule, pill, decocting by prior art Agent, capsule or powder.
4. the prosopalgic Chinese medicine composition for the treatment of as claimed in claim 1 or 2, is characterized in that: described Chinese medicine composition The dosage form of preparation be: water decoction, tablet, granule, pill, capsule or powder.
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1108114A (en) * 1994-04-05 1995-09-13 戚嘉和 Traditional Chinese medicinal prepn. for treating trifacial neuralgia
CN100998733A (en) * 2006-12-28 2007-07-18 王玉秀 Oral traditional Chinese medicine for treating trigeminal neuralgia of prolonged illness entering subsidiary channels type
CN101002865A (en) * 2006-12-28 2007-07-25 王玉秀 Oral traditional Chinese medicine for treating rheumatismal trifacial neuralgia
CN103041036A (en) * 2013-01-01 2013-04-17 李东 Pill for treating prosopalgia
CN103316130A (en) * 2013-06-24 2013-09-25 柳晖 Traditional Chinese medicine composition for treating trigeminal neuralgia
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