CN104474462A - Traditional Chinese medicine preparation for treating prosopalgia and preparation method of traditional Chinese medicine preparation - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating prosopalgia. The traditional Chinese medicine preparation comprises the following raw material medicine in parts by weight: 10-20 parts of notopterygium root, 10-20 parts of radix curcumae, 10-20 parts of curcuma zedoary, 10-20 parts of ligusticum wallichii, 10-20 parts of spina date seed, 10-20 parts of radix bupleuri, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of gastrodia elata, 10-20 parts of cicada slough, 10-20 parts of polygala tenuifolia, 10-20 parts of corydalis tuber, 10-20 parts of salviae miltiorrhizae, 10-20 parts of tuber fleeceflower stem, 10-20 parts of puerarin, 10-20 parts of loranthus parasiticus, 10-20 parts of radix paeoniae alba, 10-20 parts of fructus viticis, 10-20 parts of uncaria, 10-20 parts of scorpio, 10-20 parts of herba epimedii, 10-20 parts of silkworm larva, 10-20 parts of earthworm, 10-20 parts of rhizoma acori graminei and 10-20 parts of cinnamon. The traditional Chinese medicine preparation provided by the invention has the functions of calming the nerves and relieving pain, clearing heat and calming the liver, relieving convulsion and spasm, calming the nerves and relieving convulsion, and arresting and relieving convulsion, and is a good prescription for treating prosopalgia. The traditional Chinese medicine preparation provided by the invention quick becomes effective, is good in long-term effect and is unlikely to recur.

Description

One treats prosopalgic Chinese medicine preparation and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly one treats prosopalgic Chinese medicine preparation and preparation method thereof.

Background technology

Prosopalgic pathogenesis is up to the present still indefinite, but one of more common reason is root or semilunar ganglion pressurized after nervi trigeminus, as far back as nineteen twenty, Cushing just proposes nerve compression theory, and postmortem and to affected nerves of patients with trigeminal neuralgia implement operation time also find, most pain patients nervi trigeminus existence compressing phenomenon, be mainly tremulous pulse, vein or arteriovenous mixing compressing, compressing releasing pain can obviously be alleviated.This illustrates that trigeminal neuralgia and nerve compression exist certain relation, and also finding that there is some patients though clinical has nerve compression not clinical manifestation.Trigeminal neuralgia (Trigeminal neuralgia, TN) be a kind of chronic pain syndrome, main manifestations is the twinge of ictal, similar electric shock sample, can be spontaneous, but more commonly by faint non-nocuity, excite even at a distance, as slight touch, brush teeth, chew.For a long time, due to its sharp ache unbearably, and do not have medicine or surgical intervention can permanent radical cure, by medical circle is paid attention to.

Trigeminal neuralgia is modal cranial nerve diseases, and with the violent pain of the paroxysmal of recurrent exerbation in a side surface part nervi trigeminus areal area for main manifestations, the sickness rate 52.2/10 ten thousand of domestic statistics, female is slightly more than man, and sickness rate can increase with the age.Trigeminal neuralgia is multiple is born in middle-aged and elderly people, R)L.The feature of this disease is: in Head And Face nervi trigeminus distributed areas, and morbidity is sent out suddenly, all standing, lightning sample, the sample that lancinates, burns sample, intractable, insufferable severity pain.Speak, wash one's face, brush teeth or mild wind strokes face, having an intense pain when all can cause paroxysmal when even walking.Pain lasts several seconds or several minutes, and pain is periodical attack, and the outbreak intermission is the same with normal person.With regard to the prosopalgic cause of disease and pathogenesis, there is no clear and definite final conclusion so far, each theory all cannot explain its clinical symptoms.What support for everybody at present is that nervi trigeminus microvascular compression causes nerve demyelination theory and epileptic neuralgia theory.

Prosopalgic outbreak is normal without omen, and panic attacks is generally regular.Each panic attacks time is stopped by 1 ~ 2 minute suddenly by only last for several seconds.During initial stage onset, attack times is less, and the intermission is also long, several minutes, a few hours, not etc. with PD, outbreak was not frequent gradually, and the intermission shortens gradually, and pain also increases the weight of and violent gradually.Night, panic attacks reduced.Intermission is without any discomfort.Risk factor: speak, have a meal, wash one's face, shave, brush teeth and wind etc. all can be shown effect by Provocative pain, so that patient's lethargy is depressed, takes action overcautious, even dare not wash one's face, brushes teeth, take food, speaks also careful, lest cause outbreak.Trigger point, also known as " trigger point ", is often positioned at the places such as upper lip, the wing of nose, gums, bicker, tongue, eyebrow.Touch or stimulate trigger point to excite panic attacks; Expression and facial area change, the activities such as outbreak pipes down suddenly often, feed, pain side surface part can present spasm, i.e. " cramp ", frown and grit one's teeth, dehisce to cover order, or firmly rub face with palm so that local skin is coarse, thicken, milphae, conjunctival congestion, shed tears and sialorrhea.Expression is in psychentonia, anxiety state; Absence of signs, minority has facial perception to go down.This type of patient should inquire medical history further, and especially whether inquiry previously has hypertension history, carries out comprehensive neurologic check, comprises that waist is worn if desired, basis cranii and lnner stripe take the photograph the inspections such as sheet, cerebral CT, MRI, differentiate to help with secondary trigeminal neuralgia.

Trigeminal neuralgia can be divided into constitutional (symptomatic) trigeminal neuralgia and the large class of secondary trigeminal neuralgia two, and wherein primary trigeminal neuralgia is more common.Primary trigeminal neuralgia refers to have clinical symptoms, but applies various inspection and do not find and relevant organic disease of falling ill.Secondary trigeminal neuralgia is apart from clinical symptoms, and clinical and imaging examination can find that organic disease is as tumor, inflammation, vascular malformation etc. simultaneously.Secondary trigeminal neuralgia is more common in below 40 years old, adolescence, and usually do not have trigger point, risk factor is not obvious, and pain is often in persistence, and some patients can find to show with other of primary disease.Brain CT, MRI, nasopharynx part biopsy etc. help diagnosis.

Trigeminal neuralgia constant error is examined as toothache, is often pulled out by healthy tooth, even pulls out whole tooth still invalid, and side arouses attention.The pain that odontopathy causes is rest pain, is confined to gums portion more, and there are dental caries or other pathological changes in local, and x-ray and dental examination can be made a definite diagnosis.

Trigeminal neuralgia is known as " the first under heaven pain ".Drug therapy: carbamazepine (carbamazepine): the patient's pain relieving to 70% is effective, but side effect is very strong; The patient of about 1/3 can not tolerate the side effect such as it is drowsiness, dizzy, digestive tract is uncomfortable.Start every day 2 times, later can every day 3 times.Every day, 0.2 ~ 0.6g, point took for 2 ~ 3 times, every day maximum dose 1.2g.Phenytoin Sodium (sodium phenytoin): curative effect is not as good as carbamazepine.Treatment by Chinese herbs: have certain curative effect.TN western medicine is often difficult to because of side effect adhere to, therefore someone adopts treatment by Chinese herbs.According to reports, have the effective Chinese medicine of trigeminal neuralgia: CHAIHU GUIZHI TANG, Herba Sidae Rhombifoliae soup close cassia twig and herbaceous peony soup.GEGEN TANG, Ramulus Cinnamomi add Atracty-lodis Macrocephalae and Aconiti Praeparatae Decoction, peony and licorice decoction, Radix Bupleuri Os Draconis Concha Ostreae soup etc.In addition, domestic somebody, by saturating for acupuncture cave, massage etc. and oral medicinal herb conjunctive use, also obtains certain effect.

In addition, informal dress carbamazepine class Western medicine, easily causes medicine to adapt to, and wants to keep certain curative effect to increase dosage, forms vicious cycle.China's traditional Chinese medical herbal treatment trigeminal neuralgia compares western medicine Geng Yongdu road part, so treatment by Chinese herbs trigeminal neuralgia is obviously better than Western medicine.

Summary of the invention

Technical problem to be solved by this invention is, although have some superiority for Western medicine in the outbreak of control trigeminal neuralgia, excessively strong inhibitory action can make cerebral nerve function be affected, and produces obvious toxic and side effects.As carbamazepine, Ying Na, epilepsy amine etc., not only thoroughly can not effect a radical cure neuralgia, do not reach the object for the treatment of, and its side effect is large, drug dependence strong, produces these side effect that cannot avoid such as spirit depressing, IQ, dysnoesia, therefore not easily accepted by patient.In addition, informal dress carbamazepine class Western medicine, easily causes medicine to adapt to, and wants to keep certain curative effect to increase dosage, forms vicious cycle.Clinical in the urgent need to a kind of be not only the symptom controlling this first under heaven pain outbreak of neuralgia, but allow impaired cranial nerve reparation and regeneration from foundation, there is the effect effected a permanent cure; Also to utilize the interaction of medicine, offset or be counteracted that the issuable side effect of Western medicine, patient can relievedly be taken; And instant effect and late result good, the prosopalgic preparation of the treatment by Chinese herbs of not easily recurring.

For solving these technical barriers, the invention provides one and treat prosopalgic Chinese medicine preparation, Chinese medicine preparation described in it comprises the crude drug of following weight portion: Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Semen Ziziphi Spinosae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Gastrodiae, Periostracum Cicadae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Fructus Viticis 10 ~ 20 parts, Ramulus Uncariae Cum Uncis 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Bombyx Batryticatus 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Rhizoma Acori Graminei 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts.

The prosopalgic Chinese medicine preparation of described treatment, in Chinese medicine preparation described in it, the parts by weight of various crude drug can be: Rhizoma Et Radix Notopterygii 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, Rhizoma Curcumae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Semen Ziziphi Spinosae 10 ~ 15 parts, Radix Bupleuri 10 ~ 15 parts, Radix Saposhnikoviae 10 ~ 15 parts, 10 ~ 15 parts, Rhizoma Gastrodiae, Periostracum Cicadae 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Fructus Viticis 10 ~ 20 parts, Ramulus Uncariae Cum Uncis 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Bombyx Batryticatus 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Rhizoma Acori Graminei 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts.

The prosopalgic Chinese medicine preparation of described treatment, in Chinese medicine preparation described in it, the parts by weight of various crude drug also can be: Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Semen Ziziphi Spinosae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Gastrodiae, Periostracum Cicadae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Caulis Polygoni Multiflori 10 ~ 15 parts, Radix Puerariae 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, Fructus Viticis 10 ~ 15 parts, Ramulus Uncariae Cum Uncis 10 ~ 15 parts, Scorpio 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts, Bombyx Batryticatus 10 ~ 15 parts, Pheretima 10 ~ 15 parts, Rhizoma Acori Graminei 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of prosopalgic Chinese medicine preparation, and when the dosage form of Chinese medicine preparation described in it is tablet, its preparation method comprises the following steps:

A, Scorpio, Bombyx Batryticatus, Pheretima and Periostracum Cicadae are broken into powdery;

B, all the other crude drug are added ethanol extraction 2 times, then medicinal residues extracting in water 2 times, merge extractive liquid, is condensed into extractum;

Add starch after the medicated powder that c, extractum blend step a above-mentioned steps obtained obtain and put into tabletting machine molding.

In described step a, Scorpio, Bombyx Batryticatus, Pheretima and Periostracum Cicadae four kinds of worm medicines can be pulverized by pulverizer after cleaning, washing process, medicated powder fineness reaches more than 100 orders; Medicated powder after coarse powder carries out micronizing through superfine communication technique, makes medicated powder mean diameter be less than 100 μm; After sterilizing, for subsequent use.

In described step b, all the other crude drug can be added in the ethanol accounting for its quality 5-10 times amount heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill; Again the medicinal residues after extraction are added and account for its quality 4-8 times amount soak by water 1-2 hour, merge twice decocting liquid, filter to get filtrate; Above-mentioned two kinds of extracting solution are merged after leaving standstill, when to put into concentrating under reduced pressure machine concentrating under reduced pressure relative density be 80 DEG C 1.36 extractum, reclaim ethanol.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method for the treatment of prosopalgic Chinese medicine preparation, and the dosage form of described preparation is that the preparation method of capsule comprises:

A, first described crude drug Scorpio, Bombyx Batryticatus, Pheretima and Periostracum Cicadae four kinds of worm medicated powder are broken into coarse powder and sieve, fine powder is for subsequent use; The coarse grain that do not sieve is put into extraction pot and is added ethanol extraction 2 times, filters;

B, surplus stock medicine is added ethanol extraction 2 times, filter;

C, above-mentioned two kinds of filtrates to be merged, be condensed into extractum, decompression recycling ethanol; Spraying dry, obtains medicated powder;

The fine powder that d, collection step a obtain and the medicated powder that step c obtains incapsulate.

In described step a, first crude drug Scorpio, Bombyx Batryticatus, Pheretima and Periostracum Cicadae four kinds of worm medicated powder can be broken into coarse powder and cross sieved 120 mesh sieves, the enable fine powder amount by 120 mesh sieves is reaching 30%, collects and obtains fine powder a by the fine powder of 120 mesh sieves; Again the coarse granule not by 120 mesh sieves is dropped into multi-function extractor to extract twice, add for the first time and account for coarse granule quality 8-10 times amount ethanol extraction 1-2 hour, add for the second time and account for its 4-8 times amount ethanol extraction 1-2 hour, merge twice decocting liquid, filter to get filtrate, for subsequent use.

In described step b, surplus stock medicine can be added the soak with ethanol 1-2 hour accounting for its gross mass 5-10 times amount, extract 2 times; Filter; In described step c, two kinds of extracting solution that above-mentioned steps can be obtained merge, heating extraction 1-2 hour, concentrated, when concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, decompression recycling ethanol; Pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder.

The prosopalgic Chinese medicine preparation of described treatment, the dosage form of preparation described in it can be: injection liquor, injectable powder, lyophilized injectable powder, tablet, dispersible tablet, capsule, pellet, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid, gel, soft extract, extractum, membrane, sugar coated tablet, film coated tablet, enteric coated tablet, sucks agent, suppository or cream

Ataralgesia of the present invention, heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind, endogenous wind stopping of calming the nerves, arresting convulsion relieving convulsion is the prosopalgic good prescription for the treatment of.Western medicine has achieved the effect of affirmative as the first-selection treatment for the treatment of TN, but serious complication makes it use is restricted, and surgical method can only be applied to periphery and damages the TN caused, and will accept the risk.The present invention will improve pain, Chinese medicine conditioning, spasmolytic triplicity, foundation allow impaired cranial nerve reparation and regeneration, and will utilize the interaction of medicine, offset or be counteracted that the issuable side effect of Western medicine, make that sufferer is relieved to be taken; Instant effect and late result good, not easily recur.

Detailed description of the invention

Trigeminal neuralgia (Trigeminal neuralgia, TN) is a kind of chronic pain syndrome.For a long time, due to its sharp ache unbearably, by medical circle is paid attention to.Although have employed various ways clinical to treat, effect is still unsatisfied with.Mainly its Etiological Factor and Pathophysiology mechanism is still imperfectly understood.Neuralgia is one of department of neurology common sympton, and this kind of pain refers to the pain felt under the condition not having environmental stimuli, is also called spontaneous pain.The kind of spontaneous pain is a lot, can be divided into peripheral neuropathic pain and CNS pain by the position of pathological changes.Etiology unknown person is called primary nervous pain, has clear and definite cause of disease person to claim Secondary cases (or symptomatic) neuralgia.Diseased region can in nerve root, plexus nervorum or nerve trunk.Often name with the peripheral nerve involved by pathological changes.Prosopalgic outbreak is normal without omen, and panic attacks is generally regular.Each panic attacks time is stopped by 1 ~ 2 minute suddenly by only last for several seconds.During initial stage onset, attack times is less, and the intermission is also long, several minutes, a few hours, not etc. with PD, outbreak was not frequent gradually, and the intermission shortens gradually, and pain also increases the weight of and violent gradually.Night, panic attacks reduced.Intermission is without any discomfort.

The change of nervi trigeminus Chronic constriction injury induction maincenter input signal is the basis forming neuropathic pain.Simple surrounding opinion or centralism explain that the pathogenesis of TN is perfect all not.TN is the coefficient result of many factors, and perineural demyelination is the pathologic basis of TN, and maincenter factor is the essential condition causing TN.Pheochromocyte sAs transplant to trigeminal neuralgia have affirmative analgesic activity and without tolerance phenomenon.Because what transplant is " living cells ", it resembles one " bio-pump of living ", and can discharge enough neuroactive substances, definitely and enduringly ease the pain, therefore clinic is tried out.The partly cause that pheochromocyte sAs transplants analgesic activity may be: suppress nocuity impulsion to import medullary substance into, or reduces medullary substance relief angle neuron to the irritability of noxious stimulation.

The treatment of TN is all the time for people pay close attention to.Carbamazepine has achieved the effect of affirmative as the first-selection treatment of TN, but serious complication makes it use is restricted, and surgical method can only be applied to periphery and damages the TN caused, and will accept the risk.Therefore people are finding one method safely and effectively always.Pheochromocyte subarachnoid transplantation, as a kind of novel treatment pain method, more and more draws attention.It achieves curative effect certainly in sciatica and the pain caused treatment of tumor, and whether effective to TN, whether there is side effect, the mechanism of action, be still not clear, we have also done some tentative researchs in this experiment for this reason.

Classical Chinese medicine ancient books Huangdi's Internal Classics is thought: trigeminal neuralgia belongs to the category such as " headache ", " migraine ", " prosopodynia ", the title such as " head-wind syndrome ", " headache caused by pathogenic wind ", " wind syndrome of head " is had to record in ancient medical book, as " Plain Questions * wind opinion ": " shape of head-wind syndrome; women's head-ornaments hyperhidrosis aversion to wind, then disease is very for wind one day in the ban." because of on top, top, only wind can namely, the heresy of affection of exogenous wind-cold, seek and cause primary disease through the clear key in upper top, criminal top, Nervous and Mental Factors also can bring out this disease.Stagnation of QI due to depression of the liver, strongly fragrant fire-transformation of a specified duration, intimately pneumatic, wind-fire folder expectorant is disturbed and causes sun clearly and must not unfold, all YANG-meridians meeting into the head, the essence of five ZANG-organs and six FU-organs China QI and blood all on gather in head, all pathogens, wind, fire, phlegm-damp, blood visitor in meridians, stagnation of phlegm blood stasis, qi stagnation hemagglutination, checks meridians, causes " stagnation of QI and blood may bring about pain ".

The present invention to expelling wind and relieving convulsion, eliminating phlegmization turbid, suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion be for principle is by medicine composition compound recipes such as Rhizoma Gastrodiae, Bombyx Batryticatus, Pheretima, Scorpios.Fructus Viticis dispelling wind and relieving convulsion, Bombyx Batryticatus, Pheretima expelling wind to relieve convulsion; Rhizoma Curcumae heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind; Radix Curcumae, Cortex Cinnamomi fragrance is walked to alter and is had one's ideas straightened out; Periostracum Cicadae, Scorpio is controlled infantile convulsion and shies expectorant, tic of the limbs; Caulis Polygoni Multiflori, Rhizoma Chuanxiong invigorate blood circulation nourishing the liver pain relieving arresting convulsion; Rhizoma Gastrodiae cerebral tonic tranquillizing determines contraction; Semen Ziziphi Spinosae, Radix Polygalae is calmed the nerves dispelling wind and relieving convulsion relieving convulsion; Rhizoma Corydalis, Herba Taxilli promoting diuresis to clear away damp pathogen relieves dizziness, high fever, infantile convulsions, epilepsy, etc.; The pain relieving of Radix Curcumae resolving stagnation for tranquilization, all medicine compatibilities, energy heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind, dispelling wind and relieving convulsion relieving convulsion of calming the nerves is the prosopalgic good prescription for the treatment of.

Bombyx Batryticatus: expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble.Sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis." detailed outline ": loose wind-phlegm tuberculosis, scrofula, wind syndrome of head, wind worm toothache, skin wind skin ulcer, erysipelas is had an itch, intermittent fever due to phlegm crux, married woman's galactostasis, metrorrhagia hematochezia, children's's infantile malnutrition erosion squama body, all incised wounds, and furuncle swells wind hemorrhoid.Anticonvulsant action 10% decocting liquid 2g/kg, to Mouse oral, has obvious antagonism to the convulsions that strychnine nitrate causes.The mixture (i.e. the decoct of five brave Chinese medicine Zhuifengsans) be made up of commercially available Bombyx Batryticatus, Periostracum Cicadae etc. can reduce strychnine, pentetrazole, cocaine, and nicotine etc. cause the death toll of mice convulsion.Artificial Bombyx Batryticatus decoct also has the effect of the mice convulsion of antagonism caused by strychnine.

Periostracum Cicadae: sweet, cold.Return lung, Liver Channel.Function cures mainly loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.For diseases such as tetanus, infantile convulsion, night cry.Periostracum Cicadae can be dispelled exogenous wind, can cease endogenous wind and spasmolytic of calming the frightened again, occur tic of the limbs to tetanus, can join that Scorpio is equivalent to be used; Infantile convulsion, the nocturnal fretfulness in infants are occurred that infantile convulsion is uneasy, the equivalent use of Ramulus Uncariae Cum Uncis can be joined." not Lu ": " main children's's epilepsy; The main chronic dysentery of ash clothes." " property of medicine opinion ": " controls children's's high fever infantile convulsion from head to foot, doublely can quench the thirst.

Rhizoma Gastrodiae: be commonly use and famousr and precious Chinese medicine simply, is clinically used for the disease such as headache dizzy, numb limbs and tense tendons, infantile convulsion, epilepsy, tic, tetanus.Effect to nervus centralis: extract has obviously antagonism pentetrazole clonism effect; Gastrodin can alleviate the Epilepsy In Rabbits attack degree that coriamyrtin brings out. and Gastrodia Injection has calmness, soporific function. and Rhizoma Gastrodiae has calmness, analgesia, anticonvulsant action; Can cerebral blood flow be increased, reduce cerebral vascular resistance, light contraction cerebrovascular, increase coronary vasodilator flow; Can reduce blood pressure, decreased heart rate, has protective effect to myocardial ischemia; Gastrodia elata polysaccharide has immunocompetence." Kaibao Bencao ": main all rheumatism numbness, spasm of the limbs, children's's acute infantile convulsion, frightened gas, sharp waist knee joint, bone and muscle strengthening.

Scorpio is pungent, flat; Poisonous.Return Liver Channel.Function cures mainly endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.Scorpion extraction liquid is in mouse tumor experiment, answer 0.2ml (suitable crude drug 0.04g/ only), every large subcutaneous administration after continuous 5 days, when medication the 11st day and drug withdrawal 8 days, be 38.8% and 55.5% to the suppression ratio of cell sarcoma (SRS) solid tumor; To MA 1 breast carcinoma, administration every day is after totally 12 times, and suppression ratio is 51.8%, is 30.4% during drug withdrawal 8 days.To the survival rate comparatively matched group prolongation 12.5%-20.7% of SRS ascitic type band tumor Mus.Result shows there is obvious inhibitory action to the tumor growth of mice with tumor.The Heal complete cell death of Scorpio extract In vitro culture takes off wall.29.2% is extended to LA 1 adenocarcinoma of lung mice with tumor life span.Buthus martensii karshi tail gavage, prevention administration group S180 sarcoma suppression ratio is 45%, and therapeutic administratp group S180 sarcoma suppression ratio is 47.6%, shows that it has preventive and therapeutic action concurrently.

Radix Polygalae is bitter, pungent, tepor.GUIXIN, kidney, lung meridian.Function cures mainly Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm, detumescence.For the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Be applied to insomnia and dreamful sleep, severe palpitation, forgetful.This product toil is warm in nature, property is kind lead off sensible, can happily gas and mind tranquilizing and the heart calming, kidney qi can be led to and strong will is not forgotten, be restoring normal coordination between the heart and kidney, stabilize mind, good merchantable brand that Fructus Alpiniae Oxyphyllae is known by force.Cure mainly the diseases such as the malaise of disarmony between the heart and kidney, insomnia, palpitation with fear, normal with Poria cum Radix Pini, Dens Draconis, Cinnabaris etc. the same use of medicinal for tranquilizing mind, as Radix Polygalae ball (" Zhang Shi doctor is led to "); Control forgetful card, normal and Radix Ginseng, Poria, the same use of Rhizoma Acori Graminei, as Kaixin San (" prescriptions worth thousand gold "), if Fang Zhongzai adds Poria cum Radix Pini, namely do not forget fall apart (" Standards of Diagnosis and Treatment ")." book on Chinese herbal medicine is just ": Radix Polygalae, the wholwe-hearted kidney of merit, therefore can relieving palpitation spasmolytic, the peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, strong will power-assisted.With its gas lift, thus same Radix Ginseng, Radix Glycyrrhizae, Semen Ziziphi Spinosae, pole can lift fall into consolidating semen, handing-over extreme misery

Caulis Polygoni Multiflori is the rattan of Radix Polygoni Multiflori, and property is put down nontoxic, and sweet and slightly bitter taste has tranquilizing and blood nourishing, effect of dispelling wind and removing obstruction in the collateral.Nourish heart, calm the nerves, dredging collateral, dispel the wind.Cure mainly: insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain.Carbuncle is thin, wind furuncle moss.Complex acid Semen Ziziphi Spinosae, grows the heart-yin, mind calming god, nourishing YIN of nourishing blood; Join the clear asthenic fire of Radix Ophiopogonis, nourish heart the moon.

Rhizoma Corydalis cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.There are analgesia, calmness, syngignoscism.Hypnosis, calm to act on stabilizing: through tests such as rabbit, Mus, dog, monkeys, larger dose tetrahydropalmatine has obvious syngignoscism.B prime can obviously reduce spontaneous activity in mice and passive activity, but can not eliminate its righting reflex, and display is without anesthetic action.B prime can resist the central excitation effect of caffeine and amfetamine, the convulsions of antagonism caused by penta 4 ammonia, but can enhanced sensitivity to the peaceful caused convulsions of soil.B prime is to the trained reflex of animal selectively inhibitory action.Similar with reserpine to chlorpromazine.The sedation of Chou prime and Kui prime is all weak compared with B prime, and the central action principle of B prime is, can suppress cerebral cortex and infracortical electrical activity, especially comparatively responsive with motor cortex.But medicinal liquid directly by being applied on cortex or in lonely corticifugal experiment, all prove that B prime is not directly affect cortex.Medicinal liquid is injected the ventricles of the brain, analgesia and sedation can be produced time heavy dose of, the startle sreponse that B prime can significantly suppress chafe to cause, and network structure ascending activating system and Descending function can be blocked.These all prove that B prime has certain selection to subcortical structure.The site of action of B prime is extensive, does not resemble morphinization position single-minded, though its analgesic activity is powerful not as morphine, has good calmness and stable usefulness.

Rhizoma Curcumae is pungent, bitter, temperature.Return liver, spleen channel.Removing blood stasis promoting the circulation of QI to relieve pain: this product effect is similar to Rhizoma Sparganii, but warm concerted effort is comparatively large, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.Long-pending eliminating stagnation: this product energy circulation of qi promoting removing food stagnancy pain relieving, for eating accumulation, breast abdominal distention is vexed has a pain.Removing blood stasis, women's amenorrhea, or the lump in the abdomen addiction block of phlegm-damp congestion condensation.Promoting the circulation of QI to relieve pain: be suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, repercussive blood, can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, QI invigorating, the capable hot disease in sky, pestilence miasma, mania and irritation, and married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Herba Epimedii is pungent, sweet, warm, returns liver, kidney channel.Energy reinforcing the kidney and supporting YANG, strengthening the tendons and bones, expelling wind and removing dampness, is apt to control insufficiency of kidney-YANG, impotence and seminal emission, enuresis frequent micturition; Rheumatic arthralgia, atrophic debility of bones paralysis disease." excessive sheep is fiery, and the main impotence of " herbal classic " medicine is hindered absolutely, and " solar corona " also its treatment of first speech man is positive absolutely, and woman is cloudy absolutely, then calling into the gate of vitality, benefit kidney-Yang person is also for " book on Chinese herbal medicine is stated " cloud.The lid gate of vitality be kidney-Yang in kidney, and namely the vigour of the person is also, its so-called exhausted YANG exhaustion the moon, the not vigour of basis, how hiss in both withered.So-called physical strength profiting, Qiang Zhi, and control cold air consumptive disease, muscles and bones contraction is anxious waits card, and all it helps the event of vigour.Old man dusk octogenarian, middle age forgetful, all Yuanyang decay and can not ascensionist also.Must know that this taste is to reduce to liter, it rises.

Rhizoma Chuanxiong enters liver, spleen, three burnt three warps.Function cures mainly activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine removes vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also coronary vasodilator be expanded, increase coronary flow.The myocardial ischemia-anoxemia that antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that ligation arteria coronaria causes.

Fructus Viticis Classification system: FRUCTUS VITICIS.For anemopyretic cold, headache wind syndrome of head.The pungent wind that can fall apart of this product, be slightly cold heat clearing away, frivolous up, the heresy of main loose women's head-ornaments, and have the effect of wind-expelling pain-stopping, with controlling affection due to external wind and heat, headache and dizzy, is often equal to use with Flos Chrysanthemi, Herba Menthae, and headache wind syndrome of head normal being equal to Fructus Atriplicis Sibiricae, Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis is used.For conjunctival congestion and swelling pain, the many tear of blurred vision.This product energy dispelling wind and heat pathogens, the clear sharp head, therefore available controlling in wind heat is attacked, conjunctival congestion and swelling pain, the many tear of blurred vision, often joins Flos Chrysanthemi, Periostracum Cicadae, the equivalent use of Radix Gentianae; This product property of medicine rises to be sent out, and the clear sharp head, is equal to use with the Radix Astragali, Radix Codonopsis, the Radix Paeoniae Alba, also availablely controls clear YANG failing to ascend, and order gives birth to cataracta, and the diseases such as Hiccough and deaf, as Yiqicongming Decoction.

Pheretima: be the dry products of Lumbricus.Compendium of Material Medica is referred to as to have dredge the meridian passage, blood circulation promoting and blood stasis dispelling, the effect of prophylactic treatment cardiovascular and cerebrovascular disease.Pheretima taste cold in nature becomes.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.Cure mainly high fanatical dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, hemiplegia etc.

Ramulus Uncariae Cum Uncis is cool in nature, sweet in the mouth.Function heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.For dizzy, dysphoric cold, the diarrhea induced by fright tic of having a headache, pregnant sub-dysentery, vascular hypertension." detailed outline " carries it: " Ramulus Uncariae Cum Uncis, hands, foot faint cloudy medicine also.Foot is fainted cloudy main air, and hands is fainted cloudy main fire, the dizzy fortune of infantile convulsion, all the disease of liver-wind fire mutually, and Ramulus Uncariae Cum Uncis leads to pericardium in edema with the liver involved, and the quiet fire of wind puts out, then all diseases oneself remove." proving that it has good sedation through test, Ramulus Uncariae Cum Uncis decoct 0.1 g/kg, to mouse peritoneal injection, can produce obvious sedation, but without obvious syngignoscism.

Radix Saposhnikoviae acrid in the mouth, sweet, slightly warm in nature.Return bladder, liver, spleen channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion is jerked surely.Cure mainly diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.For headache due to common cold, rubella pruritus.Control exterior syndrome due to wind-cold, headache general pain, aversion to wind and cold person, Chang Peiwu Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis etc.; Control diseases caused by exogenous pathogenic factor rheumatism, headache as wrapped up in, heavy sensation of the body acroesthesia person, be equal to Rhizoma Et Radix Notopterygii, Rhizoma Ligustici and use; Control rubella pruritus, polygamy 5 Radix Sophorae Flavescentis, Herba Schizonepetae, Radix Angelicae Sinensis etc.Radix Saposhnikoviae joins Radix Bupleuri, Qiang's Radix Angelicae Pubescentis etc., and can fall apart wind prevailing over dampness, the lucid yang sending up antidiarrheal.I.e. "Nei Jing" cloud " clear QI in the lower part of the body, then raw lientery "; " heavy dampness inducing diarrhea " is also.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. " detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Radix Puerariae hyoscine, having induces sweat brings down a fever, the function of promoting the production of body fluid to quench thirst, antidiarrheal, and can improve the symptom such as stiffness of the nape, dizziness, headache, tinnitus of hypertensive patient.Effective ingredient is daizeol, yellow glycoside and puerarin etc.Powder of Radix Puerariae sweet in the mouth cool in nature is pungent, and having induces sweat brings down a fever, and promotes the production of body fluid, the several functions such as rash, yang invigorating antidiarrheal, can control fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, heat rash, the various diseases such as to have loose bowels.General Pachyrhizua angulatus matter is tough, and fibroid is strong.

It is supporing yang that Cortex Cinnamomi mends fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower." not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough ， Bi Weng; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared." Japan hanako materia medica ": control all pathogenic wind, mends five kinds of strain and seven kinds of impairment, logical nine orifices, sharp joint, benefit essence, improving eyesight, warm waist knee joint, and broken mass beside the umbilicus lump in the abdomen, repercussive blood, controls migratory arthralgia joint contracture, reuniting the fractured tendons and bones, granulation promoting meat.

Radix Curcumae is pungent, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman's stagnated blood epigastric pain caused by emotional factors, and cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main accumulation of blood, the therapeutic method to keep the adverse QI flowing downwards, granulation promoting, hemostasis, broken stagnant blood, stranguria with blood, hematuria, incised wound.

Herba Taxilli: bitter, sweet, flat.Gui Jing: return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension." herbal classic is met former ": She's gas of parasitic Mulberry and give birth to, property is specially dispeled the wind by wet, logical blood circulation regulating, therefore " herbal classic " is got and controlled married woman's lumbago, the diseases such as children's's stiffback, and Xuemaitong is adjusted and skin eyebrow all by its shade, namely must have carbuncle, also must dissipate." book on Chinese herbal medicine is looked for the truth ": Herba Taxilli, number wants agent for kidney tonifying and enriching blood.Edge kidney governing bones, sends out blood main, bitter man's kidney, and it is strong that kidney must mend then muscles and bones, unlikely hemorrhoid repeatly and sensation of aching.Sweetly enrich blood, blood must be mended, send out fill with shady by it and not Fructus Citri tangerinae come off.Therefore all in and lumbago, the sincere disease of muscles and bones, tire are fallen, outer and incised wound, skin rheumatism, what one is not thought whereby and cures mainly.

Semen Ziziphi Spinosae, records in China's medicine book Shennong's Herbal the earliest: " invigorating middle warmer the liver benefiting, hard muscles and bones help cloudy gas, and all the merit of Semen Ziziphi Spinosae also." record in Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica, " insomnia due to insufficiency of the gallbladder-qi in ripe treatment, the disease of excessive thirst sweating due to debility for Semen Ziziphi Spinosae; Life is treated gallbladder-heat and is slept well, and all foot faints cloudy few positive medicine also.Nourishing the liver, mind calming, calms the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.1. " herbal classic ": main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen.2. " not Lu ": main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong.3. " property of medicine opinion ": main muscles and bones wind, fry end and take it as soup.4. supplement to the Herbal: many lifes of sleeping make, and must not sleep and fry.5. Wang Haogu: control milk-livered sleeplessness, trembles with fear also, fries clothes; Control somnolence due to gallbladder-excess, heat also, use by life.6. " book on Chinese herbal medicine converges and says ": astringing QI is calmed the nerves, and flourish muscle supports marrow, stomach function regulating activating the spleen.7. " book on Chinese herbal medicine is new again ": suppressing the hyperactive liver is regulated the flow of vital energy, nourishing lung-YIN, warming middle-JIAO dampness removing, astringing QI hidroschesis, and beneficial will is breathed out surely, hearing-improing and eyesight improving.

Radix Bupleuri clearind deficient heat Chinese medicine, comes off for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus, menoxenia.Return Liver Channel, gallbladder meridian.Function: evacuate and bring down a fever, yang invigorating soothing liver-QI.Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.Treatment viral hepatitis: injection of Radix Bupleuri (every lml is containing crude drug 2g) 10 ~ 20ml adds the quiet note of 50% Glucose Liquid or quiet of 5% Glucose Liquid 250 ~ 500ml, every day 1 time was for 10 times 1 course for the treatment of, treatment viral hepatitis 120 example, wherein acute case 97 example, effective percentage is 98.4%; Chronic cases 23 example, effective percentage is 100%, all has better effect to improving symptom, retraction liver spleen, recovery liver function and hepatitis B antigen negative conversion rate.

Rhizoma Et Radix Notopterygii another name Qiang is blue or green, protect Qiang envoy, recklessly king envoy, Qiang is sliding, move back wind envoy, black powder, Latin literary fame Notopterygium incisum. Umbelliferae, Notopterygium plant, perennial herb, high 60-120 centimetre, and rhizome is sturdy, extends in Bamboo-shaped.There is withered sheath in collar portion.Stem is upright, and cylindrical, hollow, has vertical straight stria, band purple.Chinese medicine cures mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, speckle is bald; Affection of exogenous wind-cold, have a headache lossless, mimeograph cold-damp numbness, edema due to wind pathogen edema, sore swollen toxin.

Its slightly warm in nature of Rhizoma Acori Graminei, acrid in the mouth, have have one's ideas straightened out, eliminating phlegm, regulate the flow of vital energy, invigorate blood circulation, loose wind, the effect of drying, be usually used in the disease such as treatment epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, stomachache, stomachache, rheumatic arthralgia, swollen ulcer drug, traumatic injury.Removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury." herbal classic ": main anemofrigid-damp arthralgia, cough with dyspnea, happy hole, tonifying five ZANG-organs, logical nine orifices, improve visual and auditory acuity, goes out speech." not Lu ": " warming intestines and stomach, only normal urination, extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, and body accumulated heat is not understood, and can do to bathe soup for main deafness, carbuncle skin ulcer.Audition improvement order, beneficial intelligence." " property of medicine opinion ": " dispelling the wind and dampness pathogens insensitive impediment, tinnitus, wind syndrome of head, under tear, kills parasites, controls malignant boil scabies scabies.

The manufacturing process of honey pill agent of the present invention is: first by described raw materials of scorpion 1500g, Bombyx Batryticatus 1500g, Pheretima 1500g, Periostracum Cicadae 1500g, medicated powder is broken into coarse powder, then pulverizes further, crosses 120 mesh sieves, the enable fine powder amount by 120 mesh sieves is reaching 30%, collects and obtains fine powder a by the fine powder of 120 mesh sieves; Again the coarse powder not by 80 mesh sieves is dropped into multi-function extractor and extract twice, first time adds 8-10 times amount ethanol and decocts 1-2 hour, and second time adds 4-8 times amount ethanol and decocts 1-2 hour, merges twice decocting liquid, filters to get filtrate, be concentrated into extractum; Again by Rhizoma Et Radix Notopterygii 1500g, Radix Curcumae 1500g, Rhizoma Curcumae 1500g, Rhizoma Chuanxiong 1500g, Semen Ziziphi Spinosae 1500g, Radix Bupleuri 1500g, Radix Saposhnikoviae 1500g, Rhizoma Gastrodiae 1500g, Radix Polygalae 1500g, Rhizoma Corydalis 1500g, Radix Salviae Miltiorrhizae 1500g, Caulis Polygoni Multiflori 1500g, Radix Puerariae 1500g, Herba Taxilli 1500g, Radix Paeoniae Alba 1200g, Fructus Viticis 1500g, Ramulus Uncariae Cum Uncis 1500g, Herba Epimedii 1500g, Rhizoma Acori Graminei 1500g, Cortex Cinnamomi 1500g, add ethanol extraction, ethanol consumption is 10 times amount of described material medicine weight portion sum, each 30 minutes ~ 45 minutes of reflux, leaves standstill merging after 2 extracting liquid filterings; Be concentrated into extractum; The extractum obtained twice merges concentrated 80 DEG C, the baking oven of putting into of heat dries rear cooling, grinds to form fine powder, calls in Mel and make honey refining pill after worm powder mixing above-mentioned steps obtained.

The manufacturing process of capsule of the present invention is: by Scorpio 1200g, Bombyx Batryticatus 1300g, Pheretima 1200g, Periostracum Cicadae 1100g, and pulverized by pulverizer after washing process, medicated powder fineness reaches more than 100 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than the medical material of 100 μm after cleaning, drying sterilizing, for subsequent use; Again by Rhizoma Et Radix Notopterygii 1200g, Radix Curcumae 1300g, Rhizoma Curcumae 1200g, Rhizoma Chuanxiong 1200g, Semen Ziziphi Spinosae 1200g, Radix Bupleuri 1300g, Radix Saposhnikoviae 1200g, Rhizoma Gastrodiae 1200g, Radix Polygalae 1200g, Rhizoma Corydalis 1200g, Radix Salviae Miltiorrhizae 1200g, Caulis Polygoni Multiflori 1200g, Radix Puerariae 1200g, Herba Taxilli 1300g, Radix Paeoniae Alba 1200g, Fructus Viticis 1200g, Ramulus Uncariae Cum Uncis 1200g, Herba Epimedii 1200g, Rhizoma Acori Graminei 1200g, Cortex Cinnamomi 1200g, adds the soak with ethanol 1-2 hour accounting for its gross mass 5-10 times amount by surplus stock medicine, extract 2 times; Filter; Two kinds of extracting solution above-mentioned steps obtained merge, heating extraction 1-2 hour, concentrated, when concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, decompression recycling ethanol; Pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m 2, and hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder; Finally by the canned capsule of medicated powder of above-mentioned steps collection.Every capsules dress 0.3g.Can every 12 be a plate.

The preparation method of Tablets comprises: first by Scorpio 1300g, Bombyx Batryticatus 1200g, Pheretima 1100g, Periostracum Cicadae 1300g, and pulverized by pulverizer after washing process, medicated powder fineness reaches more than 100 orders; Medicated powder after coarse powder is through adding ethanol extraction 2 times, and described ethanol consumption is 10 times amount of described raw material medicines in portions by weight sum, each 30 minutes ~ 45 minutes of reflux, leaves standstill merging after 2 extracting liquid filterings; Filtrate stand for standby use; Again by Rhizoma Et Radix Notopterygii 1200g, Radix Curcumae 1300g, Rhizoma Curcumae 1200g, Rhizoma Chuanxiong 1200g, Semen Ziziphi Spinosae 1200g, Radix Bupleuri 1300g, Radix Saposhnikoviae 1200g, Rhizoma Gastrodiae 1200g, Radix Polygalae 1200g, Rhizoma Corydalis 1200g, Radix Salviae Miltiorrhizae 1200g, Caulis Polygoni Multiflori 1200g, Radix Puerariae 1200g, Herba Taxilli 1300g, Radix Paeoniae Alba 1200g, Fructus Viticis 1200g, Ramulus Uncariae Cum Uncis 1200g, Herba Epimedii 1200g, Rhizoma Acori Graminei 1200g, Cortex Cinnamomi 1200g, soak in ethanol, all the other crude drug to be added in the ethanol accounting for its quality 5-10 times amount heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; Again the medicinal residues after extraction are added and account for its quality 4-8 times amount soak by water 1-2 hour, merge twice decocting liquid, filter to get filtrate; Above-mentioned two kinds of extracting solution are merged after leaving standstill, when to put into concentrating under reduced pressure machine concentrating under reduced pressure relative density be 80 DEG C 1.36 extractum, reclaim ethanol.Collect worm powder, be mixed in extractum, add starch, put into tablet machine tabletting.

Pharmacological toxicity is tested

The animal acute toxicity test of pharmaceutical composition of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, are provided by Shandong medical college Animal Lab..

(2) test medicine: the tablet prepared by the embodiment of the present invention 3, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the capsule prepared by the embodiment of the present invention 4.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and under She, all death in 12 days is observed in 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, Skin Irritation Test: above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine preparation long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: Chinese medicine preparation experiment safety of the present invention.

Four: cumulative toxicity is tested:

Traditional Chinese medicine preparation capsule agent of the present invention presses 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation oral capsule of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Drug test:

Trigeminal neuralgia (Trigeminal neuralgia, TN) is a kind of chronic pain syndrome.For a long time, due to its sharp ache unbearably, by medical circle is paid attention to.Although have employed various ways clinical to treat, effect is still unsatisfied with.Mainly its Etiological Factor and Pathophysiology mechanism is still imperfectly understood.In order to the pathogenesis of further clear and definite Trigeminal neuralgia, find better Therapeutic Method, we devise this experiment.

Method:

1. Adult SD male rat 20, according to randomly assigne, laboratory animal is divided into operation group and sham operated rats, operation group is loosened with two chromium lines nervus infraorbitalis (the Infraorbital nerve of cerclage rat side, 10N) cause Chronic constriction injury (chronicconstriction injury, CCI), and sham operated rats only exposes 10N, not cerclage, observes postoperative Different periods rat to the threshold of reaction of mechanical stimulus and relevant pain sensation Behavioral change.

2.20 adult S-D male rats, are divided into operation group and sham operated rats at random, operation treated animal capable one-sided CCI-ION art, and sham operated rats only exposes ION, but not cerclage.In the allodynia phase, application immunohistochemistry technique, row oblongata rear and upper neck marrow frozen section c-fos dye.

3. the adult capable one-sided ccI-ION art of S-D male rat, will occur 30 of allodynia phenomenon after 2 weeks, be divided into three groups at random.Microcapsule (Bovine chromaffin cell, BCC) group: the subarachnoid space (subarachnoid space, the SAS) BBC of 10u 1 being implanted into rat; Carbamazepine group: by 50mg/kg, ip.: blank group: need not any medicine.After observing administration, ION arranges pain threshold (Pain threshold) the up time change in neighborhood.

4. the adult capable one-sided CCI-ION art of S-D male rat, will occur 20 of allodynia phenomenon after 2 weeks, be divided into two groups at random.BcC group (BBC of 10u 1 is implanted into the SAS of rat), matched group (normal saline of 10u1 is implanted into the SAS of rat).After 2 weeks, application immunohistochemistry technique, row oblongata rear and upper neck marrow frozen section c-fos dye.

Result:

1. about operation group 15 days after operation, in nervus infraorbitalis domination region, there is allodynia phenomenon in rat, compare with operation offside, preoperative and matched group and there is significant difference (P < 0.01), extremely low external stimulus (0.21 ± 0.0629) can excite the reaction of strong Pain behaviour, and as shunk back, asymmetry scratches face and aggressive behavior, continues to postoperative 30 days, then recover gradually, within postoperative about 80 days, recover preoperative level.

2. liang treated animal c ~ Fos albumen is mainly distributed in oblongata rear (Caudal medulla, and upper neck marrow (Upper cervical spinal cord CM), UCSC) in relief angle shallow-layer I, II layer, comparatively offside and matched group obviously raise (P < 0.01, there were significant differences statistically) operation homonymy c-Fos.

After 3.BBC cell transplantation, the 2nd week analgesic activity reaches peak, and continue to transplant after in 7 weeks without significant change (P > 0.05), and transplant front and matched group and compare and there is the significance difference opposite sex (P < 0.01).After transplanting, the 8th week two groups of PT all return to preoperative level, the indifference opposite sex (P > 0.05) statistically.Carbamazepine group: after medication 60min, drug effect reaches the highest, compared with the maximum analgesia threshold value of pheochromocyte group, statistically without the significance difference opposite sex (P > 0.05), but effect declines very soon, disappear after 3 hours, and yawning appears in rat, the symptom such as unstable, drowsiness of walking.

4.BBC transplants latter 2 weeks, and compared with matched group, in cM and UCSC relief angle, c-Fos positive cell number obviously reduces, and there is the significance difference opposite sex (P < 0.01) statistically.

Conclusion:

1.CcI-ION can cause trigeminal neuralgia, and after compressing releasing, pain can be alleviated.This model successfully simulate clinical because of compressing cause prosopalgic situation, simple, success rate is high.We can utilize the prosopalgic electro physiology of this model dynamic studies and pathophysiological change etc., also probe into medicine or other better Therapeutic Method by this model.

Trigeminal neuralgia (Trigeminal neuralgia, TN) be a kind of chronic pain syndrome, main manifestations is the twinge of ictal, similar electric shock sample, can be spontaneous, but more commonly by faint non-nocuity, excite even at a distance, as slight touch, brush teeth, chew.For a long time, due to its sharp ache unbearably, and do not have medicine or surgical intervention can permanent radical cure, by medical circle is paid attention to.In recent years, the nerve of infringement domination limbs caused the analysis of pain to make much progress by experiment, but related experiment within the scope of nervi trigeminus is really little.In order to clearly prosopalgic pathogenesis further, and inquire into better Therapeutic Method, set up a kind of simple, reliable and stable animal model very necessary.Based on this, we report a kind of experimental rat model.This model is domestic at present there is no report.

One, experiment material

1, on the impact (experiment 1) of mouse hot-plate induced pain

1.1 materials: female white mice, Kun Ming mice, biology department of Shandong University provides, body weight 16 ~ 20g.Equipment: constant water bath box, stopwatch, thermometer, graduated cylinder, beaker.Medicine: the suspension (low concentration 0.027mg/ml, middle concentration 0.035mg/ml, high concentration 0.067mg/m1) that capsule of the present invention is made into, carbamazepine (carbamazepine): every day 2 times, 0.2 ~ 0.6g every day (0.007g/ml), normal saline.

1.2 experimental technique

By the water bath topped up with water of constant water bath box, heating, water temperature is regulated to be (60 ± 0.5) DEG C, and preheating 10min, put 1 mice on hot plate at every turn, start timing, record occurs licking metapedes required time (s) simultaneously, select the mice licking metapedes within 30s do after experiment.Qualified mice is divided at random 5 groups each 10, measures the Basic Pain Threshold (s) of each group and record.Administration 3d, blank group fills with normal saline 15ml/kg, and positive controls fills with carbamazepine 0.0105g/kg, and the high, medium and low dosage component of this product does not fill with this product low concentration 0.027mg/ml, middle concentration 0.035mg/ml, high concentration 0.067mg/ml.After administration in 5th day, measure the pain threshold after 15min and 30min.5 note 60s of metapedes are not still licked more than 60s.

2.1.3 result of the test

Table 1 capsule of the present invention is on the impact (X ± s) of hot plate method in mice induced pain

Note: compare with blank group, * P < 0.05, * * P < 0.01.

2, to mice electrostimulation analgesic experiment (experiment 2)

2.1 laboratory animals: ICR mice, body weight 20-22g, is provided by biology department of Shandong University.

2.2 Experimental agents: carbamazepine; Invention formulation (based on capsule).

2.3 experimental techniques: get healthy mice, weigh, and put into mouse fixing device.Clean Mus tail with 75% ethanol, be coated with conducting resinl, amount stimulating electrode is in mouse tail.Battery lead plate is coated with 5% saline, carries out square wave electricity irritation (voltage 10V, frequency 1Hz, the wide 10ms of ripple) with the multiplex instrument of pharmacology physiology.Continuous electricity irritation three times (every minor tick 5min), responder of all shouting for three times is qualified mice.Experiment grouping, gets qualified mice (male female half and half), by body weight, sex random group, often organizes 10 mices.By each group of dosage to mice im administration, dosage is 60mg/kg, 60min after administration, repetitive nerve stimulation mice, and double stimulation is not shouted person, and for analgesic is effective, calculate analgesia rate (analgesia Mus number/often organize Mus number X100%), experimental result is in table 2.

The different preparation of table 2 is to mice electrostimulation analgesic experiment conclusion:

Capsule of the present invention has the effect improving white mice oxygen deficit tolerance ability.

3, to the effect (experiment 3) of rat trigeminal pain

3.1 laboratory animals: Wistar rat, body weight 200-220g, is provided by biology department of Shandong University.

3.2 Experimental agents: gastrodine liquid (Kunming, Yunnan Province pharmacy group); Invention formulation (based on tablet)

3.3 experimental techniques: get rat, male and female, random packet, often organizes 10, by each group of dosage to rat oral gavage administration, dosage 10mg/kg, 60min after administration, etherization, abdomen position is fixed, incidence cropping, cut skin, separating muscle, expose the cerebral dura mater between occipital bone and atlas, the scotcil 3ul of new preparation is got with microsyringe, at the brain door bolt lower-left 1-2mm of rat, atlas spinous process upper left side is about 1mm place, is equivalent to spinal nucleus of trigeminal nerve tail sidepiece and slowly injects, sew up the incision, put in cage and observe.Screaming with rat, getting rid of the number of times sum that head and left hind grab homonymy face is fast total attack times.Complete to occurring that the time of first set reaction is for incubation period with injection, continue experiment in three minutes and stop; React for spontaneous reaction is negative without this in three minutes, have this reaction for the spontaneous reaction positive.Experimental result, in table 3:

The different preparation of table 3 is to the effect of rat trigeminal pain

4, mouse writhing method (experiment 4)

4.1 experiment materials: choose body weight 20 ± 2g, Basic Pain Threshold was the white mice 30 of 5 ~ 15 seconds, and male and female half and half, are divided into three groups at random, first group of normal saline gavage, second group of 0.25% ibuprofen gavage, the 3rd group of this product suspension oral gavage, every day three times, continuous three days, last administration 30min

4.2 test methods: lumbar injection 0.6% acetic acid 0.1/10g, starts after 15min to observe writhing number of times, with hindlimb extension, at the bottom of abdomen cage, abdominal muscle interval is shunk, and body reverses as index, writhing number of times in statistics 10min.The results are shown in Table 4.

Table 2 writhing assay result (X ± s)

Note: with normal saline group than * P < 0.05, * * P < 0.01

Four, discuss

Prosopalgic pathogenesis is up to the present still indefinite, but one of more common reason is root or semilunar ganglion pressurized after nervi trigeminus, as far back as nineteen twenty, Cushing just proposes nerve compression theory, and postmortem and to affected nerves of patients with trigeminal neuralgia implement operation time also find, most pain patients nervi trigeminus existence compressing phenomenon, be mainly tremulous pulse, vein or arteriovenous mixing compressing, compressing releasing pain can obviously be alleviated.This illustrates that trigeminal neuralgia and nerve compression exist certain relation, and also finding that there is some patients though clinical has nerve compression not clinical manifestation.

Trigeminal neuralgia (Trigeminal neuralgia, TN) be a kind of chronic pain syndrome, main manifestations is the twinge of ictal, similar electric shock sample, can be spontaneous, but more commonly by faint non-nocuity, excite even at a distance, as slight touch, brush teeth, chew.For a long time, due to its sharp ache unbearably, and do not have medicine or surgical intervention can permanent radical cure, by medical circle is paid attention to.In recent years, the nerve of infringement domination limbs caused the analysis of pain to make much progress by experiment, but related experiment within the scope of nervi trigeminus is really little.Although have some superiority for Western medicine in the outbreak of control trigeminal neuralgia, excessively strong inhibitory action can make cerebral nerve function be affected, and produces obvious toxic and side effects.As carbamazepine, Ying Na, epilepsy amine etc., not only thoroughly can not effect a radical cure neuralgia, do not reach the object for the treatment of, and its side effect is large, drug dependence strong, produces these side effect that cannot avoid such as spirit depressing, IQ, dysnoesia, therefore not easily accepted by patient.In addition, informal dress carbamazepine class Western medicine, easily causes medicine to adapt to, and wants to keep certain curative effect to increase dosage, forms vicious cycle.Clinical in the urgent need to a kind of be not only the symptom controlling this first under heaven pain outbreak of neuralgia, but allow impaired cranial nerve reparation and regeneration from foundation, there is the effect effected a permanent cure; Also to utilize the interaction of medicine, offset or be counteracted that the issuable side effect of Western medicine.TN western medicine is often difficult to because of side effect adhere to, therefore someone adopts treatment by Chinese herbs.According to reports, have the effective Chinese medicine of trigeminal neuralgia: CHAIHU GUIZHI TANG, Herba Sidae Rhombifoliae soup close cassia twig and herbaceous peony soup.GEGEN TANG, Ramulus Cinnamomi add Atracty-lodis Macrocephalae and Aconiti Praeparatae Decoction, peony and licorice decoction, Radix Bupleuri Os Draconis Concha Ostreae soup etc.In addition, domestic somebody, by saturating for acupuncture cave, massage etc. and oral medicinal herb conjunctive use, also obtains certain effect.

The present invention to expelling wind and relieving convulsion, eliminating phlegmization turbid, suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion be for principle is by medicine composition compound recipes such as Rhizoma Gastrodiae, Bombyx Batryticatus, Pheretima, Scorpios.Fructus Viticis dispelling wind and relieving convulsion, Bombyx Batryticatus, Pheretima expelling wind to relieve convulsion; Rhizoma Curcumae heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind; Radix Curcumae, Cortex Cinnamomi fragrance is walked to alter and is had one's ideas straightened out; Periostracum Cicadae, Scorpio is controlled infantile convulsion and shies expectorant, tic of the limbs; Caulis Polygoni Multiflori, Rhizoma Chuanxiong invigorate blood circulation nourishing the liver pain relieving arresting convulsion; Rhizoma Gastrodiae cerebral tonic tranquillizing determines contraction; Semen Ziziphi Spinosae, Radix Polygalae is calmed the nerves dispelling wind and relieving convulsion relieving convulsion; Rhizoma Corydalis, Herba Taxilli promoting diuresis to clear away damp pathogen relieves dizziness, high fever, infantile convulsions, epilepsy, etc.; The pain relieving of Radix Curcumae resolving stagnation for tranquilization, all medicine compatibilities, energy heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind, dispelling wind and relieving convulsion relieving convulsion of calming the nerves is the prosopalgic good prescription for the treatment of.The present invention will improve pain, Chinese medicine conditioning, spasmolytic triplicity, foundation allow impaired cranial nerve reparation and regeneration, and will utilize the interaction of medicine, offset or be counteracted that the issuable side effect of Western medicine, make that sufferer is relieved to be taken; Instant effect and late result good, not easily recur.

Claims (10)

1. the prosopalgic Chinese medicine preparation for the treatment of, it is characterized in that, described Chinese medicine preparation comprises the crude drug of following weight portion: Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Semen Ziziphi Spinosae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Gastrodiae, Periostracum Cicadae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Fructus Viticis 10 ~ 20 parts, Ramulus Uncariae Cum Uncis 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Bombyx Batryticatus 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Rhizoma Acori Graminei 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts.

2. treat prosopalgic Chinese medicine preparation according to claim 1, it is characterized in that, in described Chinese medicine preparation, the parts by weight of various crude drug are: Rhizoma Et Radix Notopterygii 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, Rhizoma Curcumae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Semen Ziziphi Spinosae 10 ~ 15 parts, Radix Bupleuri 10 ~ 15 parts, Radix Saposhnikoviae 10 ~ 15 parts, 10 ~ 15 parts, Rhizoma Gastrodiae, Periostracum Cicadae 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Fructus Viticis 10 ~ 20 parts, Ramulus Uncariae Cum Uncis 10 ~ 20 parts, Scorpio 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, Bombyx Batryticatus 10 ~ 20 parts, Pheretima 10 ~ 20 parts, Rhizoma Acori Graminei 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts.

3. treat prosopalgic Chinese medicine preparation according to claim 1, it is characterized in that, in described Chinese medicine preparation, the parts by weight of various crude drug are: Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Semen Ziziphi Spinosae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Gastrodiae, Periostracum Cicadae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Caulis Polygoni Multiflori 10 ~ 15 parts, Radix Puerariae 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, Fructus Viticis 10 ~ 15 parts, Ramulus Uncariae Cum Uncis 10 ~ 15 parts, Scorpio 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts, Bombyx Batryticatus 10 ~ 15 parts, Pheretima 10 ~ 15 parts, Rhizoma Acori Graminei 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts.

4. according to any one of claims 1 to 3, treat a preparation method for prosopalgic Chinese medicine preparation, it is characterized in that, when the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:

A, Scorpio, Bombyx Batryticatus, Pheretima and Periostracum Cicadae are broken into powdery;

B, all the other crude drug are added ethanol extraction 2 times, then medicinal residues extracting in water 2 times, merge extractive liquid, is condensed into extractum;

Add starch after the medicated powder that c, extractum blend step a above-mentioned steps obtained obtain and put into tabletting machine molding.

5. treat the preparation method of prosopalgic Chinese medicine preparation according to claim 4, it is characterized in that, in described step a, Scorpio, Bombyx Batryticatus, Pheretima and Periostracum Cicadae four kinds of worm medicines are pulverized by pulverizer after cleaning, washing process, medicated powder fineness reaches more than 100 orders; Medicated powder after coarse powder carries out micronizing through superfine communication technique, makes medicated powder mean diameter be less than 100 μm; After sterilizing, for subsequent use.

6. treat the preparation method of trigeminal neuralgia Chinese medicine preparation according to claim 4, it is characterized in that, in described step b, all the other crude drug to be added in the ethanol accounting for its quality 5-10 times amount heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; Again the medicinal residues after extraction are added and account for its quality 4-8 times amount soak by water 1-2 hour, merge twice decocting liquid, filter to get filtrate; Above-mentioned two kinds of extracting solution are merged after leaving standstill, when to put into concentrating under reduced pressure machine concentrating under reduced pressure relative density be 80 DEG C 1.36 extractum, reclaim ethanol.

7. according to any one of claims 1 to 3, treat a preparation method for prosopalgic Chinese medicine preparation, it is characterized in that, the dosage form of described preparation is that the preparation method of capsule comprises:

A, first described crude drug Scorpio, Bombyx Batryticatus, Pheretima and Periostracum Cicadae four kinds of worm medicated powder are broken into coarse powder and sieve, fine powder is for subsequent use; The coarse grain that do not sieve is put into extraction pot and is added ethanol extraction 2 times, filters;

B, surplus stock medicine is added ethanol extraction 2 times, filter;

C, above-mentioned two kinds of filtrates to be merged, be condensed into extractum, decompression recycling ethanol; Spraying dry, obtains medicated powder;

The fine powder that d, collection step a obtain and the medicated powder that step c obtains incapsulate.

8. treat the preparation method of prosopalgic Chinese medicine preparation according to claim 7, it is characterized in that, in described step a, first crude drug Scorpio, Bombyx Batryticatus, Pheretima and Periostracum Cicadae four kinds of worm medicated powder are broken into coarse powder and cross sieved 120 mesh sieves, the enable fine powder amount by 120 mesh sieves is reaching 30%, collects and obtains fine powder a by the fine powder of 120 mesh sieves; Again the coarse granule not by 120 mesh sieves is dropped into multi-function extractor to extract twice, add for the first time and account for coarse granule quality 8-10 times amount ethanol extraction 1-2 hour, add for the second time and account for its 4-8 times amount ethanol extraction 1-2 hour, merge twice decocting liquid, filter to get filtrate, for subsequent use.

9. treat the preparation method of trigeminal neuralgia Chinese medicine preparation according to claim 7, it is characterized in that, in described step b, surplus stock medicine is added the soak with ethanol 1-2 hour accounting for its gross mass 5-10 times amount, extract 2 times; Filter; In described step c, two kinds of extracting solution above-mentioned steps obtained merge, heating extraction 1-2 hour, concentrated, when concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, decompression recycling ethanol; Pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder.

10. according to any one of claim 1 ~ 9, treat prosopalgic Chinese medicine preparation, it is characterized in that, the dosage form of described preparation is: injection liquor, injectable powder, lyophilized injectable powder, tablet, dispersible tablet, capsule, pellet, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid, gel, soft extract, extractum, membrane, sugar coated tablet, film coated tablet, enteric coated tablet, sucks agent, suppository or cream.