CN106074833A - The medicine of the pathological changes that treatment is caused by rheumatism and preparation method - Google Patents

The medicine of the pathological changes that treatment is caused by rheumatism and preparation method Download PDF

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CN106074833A
CN106074833A CN201610449700.8A CN201610449700A CN106074833A CN 106074833 A CN106074833 A CN 106074833A CN 201610449700 A CN201610449700 A CN 201610449700A CN 106074833 A CN106074833 A CN 106074833A
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radix
medicine
rheumatic
patch
rheumatism
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刘晓东
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
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    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia

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Abstract

The present invention relates to medicine of pathological changes that a kind for the treatment of causes and preparation method thereof by rheumatism, it is by Flos Carthami, the Radix Rehmanniae, Olibanum, Radix Polygalae, Herba Lycopodii, Radix Aconiti, Agkistrodon, Realgar, Fructus Forsythiae, Radix Angelicae Sinensis, Herba Ephedrae, Radix Tripterygii Wilfordii, Radix Sanguisorbaes etc. form, and can make outer application Chinese medicinal ointment patch, have good therapeutic effect for diseases such as rheumatic arthritis.

Description

The medicine of the pathological changes that treatment is caused by rheumatism and preparation method
Technical field
The present invention relates to pharmaceutical formulation and preparation method thereof field, be specifically related to the pathological changes that a kind for the treatment of causes by rheumatism Pharmaceutical formulation and preparation method thereof.
Background technology
Rheumatic arthritis belongs to the traditional Chinese medical science " numbness is sick " category, is a kind of clinical manifestation of rheumatic fever, and its etiology and pathology is so far The brightest.Its typical clinical manifestations is migrans polyarthritis, mostly be knee joint, step on, take on, the big joint symmetry such as elbow wrist is got involved, often Seeing and be transferred to another joint by a joint, local joint may occur in which red and swollen heat pain, with rubescent, swelling, joint during pain Around having tenderness, tenderness, skin can have erythema iris and subcutaneous nodule.After pain disappears, do not leave over ankylosis or deformity, close Joint function can be recovered.The traditional Chinese medical science thinks that the pathogenic factor such as wind, cold, wet, heat stays note muscle, muscles and bones, joint, causes QI-blood circulation not smooth, limb The basic pathogenesis into primary disease is supported in body spasm of muscles and vessels, mistake, and numbness disease does not heals, and gos deep into anatomy, occurs that cold skin addiction speckle, arthroncus are abnormal The diseases such as shape.
Rheumatic arthritis can cause these pathological changes following:
1: rheumatic carditis；
Secondly a kind of rheumatic heart disease: rheumatic endocarditis often encroaches on cardiac valve, and wherein Bicuspid valve is the most often involved be Bicuspid valve with Aortic valve is got involved simultaneously.Tricuspid valve and valve of pulmonary trunk are not typically involved.Chordae tendineae and left atrial wall inner membrance the most also can be invaded Evil.Pathological changes Early manifestation is serosity endocarditis, valve swelling, bright, but during postmortem, this early changes is hardly visible.
2: rheumatic pericarditis
During rheumatism, pericardium is the most always involved, but clinically, the rheumatic pericarditis case of only 15% is diagnosed.Pathological changes is main Involving pericardium viscerale, in serosity or serofibrinous inflammation, visceral pericardium connective tissue can occur cellulose sample.In pericardial cavity A large amount of serosity can be had to ooze out.
3: rheumatic arthritis
There is rheumatic arthritis in early days in about 75% rheumatic fever patient.Often involve big joint, be most commonly in knee joint and ankle joint, secondly It is the joints such as shoulder, wrist, elbow.Each joint Chang Xianhou gets involved, recurrent exerbation, and red, swollen, hot, pain and dysfunction occurs in local.
4: rheumatic arteritis
Rheumatic arteritis can betide coronary artery, renal artery, Mesenteric artery, cerebral arteries, aorta and pulmonary artery etc..Anxious The property phase, blood vessel wall generation mucoid and fibrinoid necrosis, with inflammatory cell infiltration, Aschoff corpusculum can be had to be formed, and can Secondary thrombus is formed.In the later stage, blood vessel wall is because of cicatrization in irregular thickening, and tube chamber is narrow and small.
5: central nervous system pathological change
Being more common in 5～12 years old child, girl is more than boy.Major lesions is rheumatic arteritis, can have refreshing cell, glial cell Hypertrophy and Glial nodules are formed.Pathological changes mainly involves cerebral cortex, Basal ganglia, thalamus and cerebellar cortex.When extrapyramidal system is subject to When tiring out heavier, there is the involuntary movement of limbs, the least chorea in infant.
6: skin exudative process
There is erythema iris in trunk and limbs skin, for annular or the light red mottle of semi-circular, within 1st～2, can disappear, betide rheumatism The acute stage of heat, rheumatic fever there is diagnostic significance.Under mirror, the high dermis congestion of blood vessel at erythema, blood vessel four sides edema and Inflammatory cell infiltration.
In prior art, the ZL201210528767.2 that the present inventor submits to discloses the disease that a kind for the treatment of is caused by rheumatism The pharmaceutical formulation become, its composition and percentage by weight are respectively as follows: Flos Carthami 5-10g, Semen Persicae 5-10g, Olibanum 5-10g, Myrrha 5- 10g, god muscle grass 5-10g, Radix Aconiti 5-10g, Agkistrodon 10-15g, Realgar 5-10g, Radix Notoginseng 5-10g, Radix Angelicae Sinensis 5-10g, Herba Ephedrae 10- 20g, Radix Tripterygii Wilfordii 5-10g.But, in follow-up research, inventor finds, although the pharmaceutical formulation of this patent can be effectively Treatment rheumatism, therapeutic effect still has shortcoming.In further exploratory development, the present inventor is changed for this side Enter, thus further improve therapeutic effect, thus complete the present invention.
Summary of the invention
It is an object of the invention to provide the medicine of the pathological changes that a kind for the treatment of is caused by rheumatism.
In order to achieve the above object, the present invention provides the medicine of the pathological changes that a kind for the treatment of causes by rheumatism, and it mainly includes The Chinese medicines such as Flos Carthami, Olibanum, Myrrha, god's muscle grass.
Preferably, described medicine also includes the component such as the Radix Rehmanniae, Radix Aconiti.
It is highly preferred that the present invention provides the medicine of the pathological changes that a kind for the treatment of causes by rheumatism, its composition and percentage by weight It is respectively as follows: Flos Carthami 5-10g, Radix Rehmanniae 5-10g, Olibanum 5-10g, Radix Polygalae 5-10g, Herba Lycopodii 5-10g, Radix Aconiti 5-10g, Agkistrodon 10-15g, Realgar 5-10g, Fructus Forsythiae 5-10g, Radix Angelicae Sinensis 5-10g, Herba Ephedrae 10-20g, Radix Tripterygii Wilfordii 5-10g, Radix Sanguisorbae 1-5g.
In a preferred embodiment, composition and the percentage by weight of described medicine is respectively as follows: Flos Carthami 8 g, the Radix Rehmanniae 8g, Olibanum 8g, Radix Polygalae 8g, Herba Lycopodii 8g, Radix Aconiti 8g, Agkistrodon 15g, Realgar 8g, Fructus Forsythiae 8g, Radix Angelicae Sinensis 8g, Herba Ephedrae 15g, Thunder God Rattan 8g, Radix Sanguisorbae 3g.
In a preferred embodiment, described medicine is outer application Chinese medicinal ointment patch.
In one aspect, the preparation method of the medicine of the present invention, comprise the following steps:
1, each crude drug is weighed by above-mentioned weight portion, standby；
2., by each crude drug grind into powder, obtain mixture of powders；
3. vaseline is heated to 80-100 DEG C of thawing, is subsequently adding mixture of powders, stirs, obtain pasty mixture, stir Mix uniformly, obtain Chinese medicinal ointment；
4. Chinese medicinal ointment is smeared on patch carrier, obtain outer application Chinese medicinal ointment patch.
Further, the conventional carrier used during described patch carrier uses existing patch.
But, the present invention is not limited in using Chinese medicine patch, and after prepared Chinese medicinal ointment, those skilled in the art can make By various technology by medicament administration in human body, thus treat.
The present invention each crude drug component compatibility, scientific combination, with the use of, need and use mutually, without obvious toxic-side effects, have Short treating period, the advantage that cure rate is high, can effectively treat the various pains of various pathological changes and the body interior caused by rheumatism Shape.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further.Following example are only the several concrete reality of the present invention Execute example, but the design concept of the present invention is not limited thereto, all changes utilizing this design that the present invention carries out unsubstantiality, all The behavior invading scope should be belonged to.
The following percentage composition in embodiment if no special instructions, is weight/mass percentage composition.
Embodiment 1
Flos Carthami 8 g, Radix Rehmanniae 8g, Olibanum 8g, Radix Polygalae 8g, Herba Lycopodii 8g, Radix Aconiti 8g, Agkistrodon 15g, Realgar 8g, Fructus Forsythiae 8g, Radix Angelicae Sinensis 8g, Herba Ephedrae 15g, Radix Tripterygii Wilfordii 8g, Radix Sanguisorbae 3g.
Each crude drug is weighed by above-mentioned weight portion, standby；By each crude drug grind into powder, obtain mixture of powders；By all Intellectual circle is heated to 90 DEG C of thawings, is subsequently adding mixture of powders, stirs, obtain pasty mixture, stir, obtains Chinese medicine Cream；Chinese medicinal ointment is smeared on patch carrier, obtain outer application Chinese medicinal ointment patch.
Embodiment 2
Flos Carthami 8 g, Radix Rehmanniae 7g, Olibanum 6g, Radix Polygalae 8g, Herba Lycopodii 10g, Radix Aconiti 8g, Agkistrodon 12g, Realgar 10g, Fructus Forsythiae 8g, when Return 8g, Herba Ephedrae 15g, Radix Tripterygii Wilfordii 8g, Radix Sanguisorbae 5g.
Preparation method is with embodiment 1.
Embodiment 3
Treatment rheumatic arthritis effect comparative test
Use the medicine (calling medicine of the present invention in the following text) of following test comparing embodiment 1 and the embodiment of ZL201210528767.2 The medicine (calling drugs compared in the following text) of one compares:
Animal packet and model preparation method: taking the male SD rat after adaptability is fed 7 days, body weight 180-220g, at ether Under light anesthesia, in the aseptic intradermal injection Freund's complete adjuvant of right metapedes sole of the foot portion (primary side), (prepared by Freund's complete adjuvant CFA: take After anhydrous lanolin heating, measure 4ml, slightly add liquid paraffin 6ml after cooling, grind rear 70 DEG C of autoclavings, by every milli The bacillus calmette-guerin vaccine 10mg rising addition 80 DEG C inactivation 1h make) 0.1ml, induction produces adjuvant-induced arthritis.After inoculation CFA, 9d measures big The left back foot of Mus (secondary side) swelling degree, observes arthritis reaction.The rat that will appear from polyarthritis symptom is divided at random Group: model group, drugs compared group, medicine group of the present invention, often organizes each 10.
Medication: 10d starts external application administration after inoculation CFA, is administered 12d altogether, observes (1) swelling degree of the paw: point Not model copy day, cause inflammation after 10d, 14d, 18d, 21d (be i.e. administered day, be administered after 4d, 8d, 11d) with inelastic Soft tape measuring rat left back sole of the foot fixed position Zhou Jing, calculates each group of rat paw edema degree.Before and after swelling is model copy All footpaths poor.(2): arthritis index (AI): after causing inflammation, 21d measures respectively group general joint lesion degree.Hologathy Become by 5 grades of scoring system in post-therapeutic evaluations, according to the lesion degree accumulation score of remaining 3 limbs of non-injection adjuvant, calculate index.Mark Accurate as follows: 0 point: without red and swollen；1 point: little toe redness and swelling of joints；2 points: toe joint and pedal swelling；3 points: the sufficient pawl below ankle joint Swelling；4 points: the whole foot pawl swelling including ankle joint.The accumulation in each joint is scored, is every rat and closes The index of joint swelling.Result of the test show medicine of the present invention compared with drugs compared, foot left to adjuvant-induced arthritis animal model There is bigger gap in the impact of pawl swelling and arthritis index, shows that the medicine of the present invention has more preferable therapeutic effect.
The table 1. impact on adjuvant-induced arthritis animal model
Embodiment 4
The following is patient and use the clinical statistics data of medicine of the present invention:
1. basic document
Gather hospital admission patient, be diagnosed as patient's totally 240 example of rheumatic arthritis, the maleest 118 examples, female 122 example, age 35～70 years old, the state of an illness 3～10 years.
Experiment packet
Patient is randomly divided into 3 groups, including treatment group 1, treatment group 2, matched group, often organizes 80 examples.
Therapeutic scheme
Treatment group 1 uses the medicine of embodiment 1, and every 2 days 1 patches, continuous 15 days are 1 course for the treatment of；Treatment group 2 uses embodiment 2 Medicine, every 2 days 1 patches, continuous 15 days are 1 course for the treatment of；Matched group uses control drug, and every 2 days 1 patches, taking continuously 15 days is one The individual course for the treatment of.Treatment group and matched group all observe 4 courses for the treatment of.
Efficacy determination
The efficacy assessment standard of rheumatic arthritis draft for cure: ankylosis, swell and ache and clinical sign disappear；Effective: to close Save stiff, swelling and ache alleviates；Do not heal: symptom is without substantially changing.
Statistical procedures
Using SPSS20.0 statistical software to be analyzed, enumeration data uses X 2 test, and measurement data uses t inspection.With P < 0.05 is that difference is statistically significant.
Experimental result
Treatment group 1 cures 63 examples, effective 10 examples, invalid 7 examples, total effective rate 91.25%；Treatment group 2 cures 53 examples, and effective 21 Example, invalid 6 examples, total effective rate 92.5%；Matched group cures 17 examples, effective 32 examples, invalid 31 examples, total effective rate 61.25%.Control Treatment group compares with matched group, and difference is statistically significant.Treatment group clinical efficacy is significantly better than matched group.

Claims (10)

1. a medicine, it mainly includes the Chinese medicines such as Flos Carthami, Olibanum, Myrrha, god's muscle grass.
2. the medicine described in claim 1, also includes the component such as the Radix Rehmanniae, Radix Aconiti.
3. the medicine of claim 1 or 2, its composition and percentage by weight are respectively as follows: Flos Carthami 5-10g, Radix Rehmanniae 5-10g, Olibanum 5- 10g, Radix Polygalae 5-10g, Herba Lycopodii 5-10g, Radix Aconiti 5-10g, Agkistrodon 10-15g, Realgar 5-10g, Fructus Forsythiae 5-10g, Radix Angelicae Sinensis 5- 10g, Herba Ephedrae 10-20g, Radix Tripterygii Wilfordii 5-10g, Radix Sanguisorbae 1-5g.
4. the medicine of claim 3, the composition of described medicine and percentage by weight be respectively as follows: Flos Carthami 8 g, Radix Rehmanniae 8g, Olibanum 8g, Radix Polygalae 8g, Herba Lycopodii 8g, Radix Aconiti 8g, Agkistrodon 15g, Realgar 8g, Fructus Forsythiae 8g, Radix Angelicae Sinensis 8g, Herba Ephedrae 15g, Radix Tripterygii Wilfordii 8g, Radix Sanguisorbae 3g。
5. the medicine of claim 1-4, described medicine is outer application Chinese medicinal ointment patch.
6. the preparation method of the medicine of claim 5, comprises the following steps:
Each crude drug is weighed by above-mentioned weight portion, standby；
By each crude drug grind into powder, obtain mixture of powders；
Vaseline is heated to 80-100 DEG C of thawing, is subsequently adding mixture of powders, stirs, obtain pasty mixture, stirring Uniformly, Chinese medicinal ointment is obtained；
Chinese medicinal ointment is smeared on patch carrier, obtain outer application Chinese medicinal ointment patch.
7. the method for claim 6, described patch carrier uses the conventional carrier used in existing patch.
8. the medicine that claim 1-5 is arbitrary application in the medicine of the pathological changes caused by rheumatism is treated in preparation.
9. the application of claim 8, the wherein said pathological changes caused by rheumatism is rheumatic arthritis and complication thereof.
10. the application of claim 9, wherein said complication is selected from rheumatic carditis, rheumatic pericarditis, rheumatic tremulous pulse Inflammation, central nervous system pathological change, skin exudative process.
CN201610449700.8A 2016-06-21 2016-06-21 The medicine of the pathological changes that treatment is caused by rheumatism and preparation method Pending CN106074833A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108186795A (en) * 2018-03-08 2018-06-22 广西中医药大学 A kind of graphene precious jade medicine plaster for treating rheumatic arthritis and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1175441A (en) * 1997-07-10 1998-03-11 迟经惠 Medicine for releasing wind-heat toxin in blood
CN1387900A (en) * 2002-07-26 2003-01-01 宋金法 Medicine ointment for eliminating pain of bones and muscles
CN101982195A (en) * 2010-10-28 2011-03-02 李桂宾 Medicine for treating rheumatoid arthritis pain and preparation method thereof
CN103705894A (en) * 2013-12-24 2014-04-09 李媛春 Traditional Chinese medicine decoction for treating rheumatoid arthritis
CN103860686A (en) * 2012-12-10 2014-06-18 刘伟忠 Formula and preparation method of medicine for treating pathologies caused by rheumatism

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1175441A (en) * 1997-07-10 1998-03-11 迟经惠 Medicine for releasing wind-heat toxin in blood
CN1387900A (en) * 2002-07-26 2003-01-01 宋金法 Medicine ointment for eliminating pain of bones and muscles
CN101982195A (en) * 2010-10-28 2011-03-02 李桂宾 Medicine for treating rheumatoid arthritis pain and preparation method thereof
CN103860686A (en) * 2012-12-10 2014-06-18 刘伟忠 Formula and preparation method of medicine for treating pathologies caused by rheumatism
CN103705894A (en) * 2013-12-24 2014-04-09 李媛春 Traditional Chinese medicine decoction for treating rheumatoid arthritis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108186795A (en) * 2018-03-08 2018-06-22 广西中医药大学 A kind of graphene precious jade medicine plaster for treating rheumatic arthritis and preparation method thereof

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