CN104815090B - A kind of external preparation and preparation method thereof for treating closed injury - Google Patents
A kind of external preparation and preparation method thereof for treating closed injury Download PDFInfo
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Abstract
The present invention relates to a kind of external preparations and preparation method thereof for treating closed injury, 1) it the following steps are included: weigh nine kinds of medicinal materials such as the coptis, radix scutellariae, Cortex Phellodendri, rheum officinale, cattail pollen, Radix Notoginseng, lycopodium calvatum, lopseed, calamine by weight, smashing and grinding, it sieves with 100 mesh sieve, it is spare to obtain fine medicinal material powder；2) it weighs by weight after stearic acid, castor oil, liquid paraffin mix in container, is heated to 70-80 DEG C, adds above-mentioned fine medicinal material powder, stir to obtain oily phase while hot；3) it weighs by weight after triethanolamine, glycerol and distilled water mixes in another container, is heated to 70-80 DEG C of miscible water phase；4) water phase is slowly added in oily phase, it is stirring while adding at 70-80 DEG C, it emulsifies it completely, is cooled to room temperature and obtains the external preparation.External preparation of the present invention has relaxing tendons and activating collaterals, scattered stasis detumescence, and anti-inflammatory analgetic eliminates fatigue, promotes to recycle unobstructed and other effects.Meanwhile it being able to maintain the body reaction that capillary permeability increases when to inflammation swelling, the inflammatory cell infiltration of body is lighter, and the reproduction reparation of own cells can be gone on smoothly, and rear function is good.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of external preparation for treating closed injury and its preparation
Method.
Background technique
Soft tissue injury caused by fracture, dislocation, osteonecrosis, bruise is in the dialectical middle subordination of orthopedics and traumatology of Chinese medicine in " injury of the tissues "
Scope, many Gu medicine writings have very detailed discussion.Huangdi's Internal Classics just have many records, if " generation of Plain Questions the five internal organs "
Record: " all muscle persons, come under section." muscle is born in bone, it is in relation between joint." a Plain Questions paralysis opinion piece " is with " penis main beam bone
And sharp joint." having vividly described the function of muscle, i.e. muscle has constraint joint and makes the flexibly effect of joint flexion-extension motion；
" the big opinion of Plain Questions YIN YANG classification of natural phenomena " is pointed out: " impairment of QI resulting in pain ", " injury of configuration resulting in swelling ", it is believed that first then swell person bitterly, impairment of QI resulting in injury of the configuration；It first swells then
Pain person is injury of configuration resulting in impairment of QI.When human body is fought with by external force, blood vessels channels and collaterals are dampened, and vim and vigour running is unsmooth, the resistance of channels and collaterals tendon and vessel mechanism of qi lattice,
Not general rule pain, and have the opinion of " all pains, which are shot a glance at, is born in gas ".When gas injury, Local Block, battalion defends not all right, mechanism of qi occlusion, hematogenous blockage
It just will form addiction blood, that is, so-called " qi as the commander of blood "." stagnation of the circulation of vital energy blood addiction, blood overflow, and arteries and veins is outer, train of thought is obstructed " is motherland's medicine pair
The interpretation of the cause, onset and process of an illness understanding of soft tissue injury (injury of tendon and muscle) caused by fracture, dislocation, bruise.The fundamentum of Chinese traditional treatment traumatology pain is
The promoting flow of qi and blood circulation, eliminating blood stasis and smoothing collaterals, and wind-dispelling, cold dispelling, dehumidifying, heat-clearing and Shu Jingtong are cooperated according to the constitution of patient with suiting measures to different persons
Network, nourishing qi and blood, benefit nourishing liver and kidney method etc..
Western medical treatment fracture and soft tissue injury are frequently with the fixed method braked in part, but outer fixed system for a long time
It is dynamic not only to bring pain to patient, but also be even more to influence the blood circulation of part and make wound healing less effective.When damage is sent out
When raw, soft tissue injury is usually existed simultaneously with fracture, therefore positive treatment fracture and soft tissue injury is of far-reaching significance, otherwise
Not only can delay treatment best opportunity, and will affect the healing effect of fracture, even result in fracture delayed healing or even not
Healing etc..
Modern medicine proves that percutaneous dosing is a kind of simple and effective administration mode, and use Chinese medicine carry out washout or
Person is applied with, and after drug and skin contact, big portion can enter medicine-feeding part by skin, is locally playing drug effect, while a part
Drug can enter blood circulation, play a role in whole body.Percutaneous dosing has the advantages that 3 is big: drug is hardly by liver and stomach and intestine
The influence of " first pass effect " in road, utilization ratio of drug is high, can reduce the damage to stomach, liver；Drug be can avoid in liver or stomach
Degradation or inactivation in enteron aisle；Can rate as needed drug transdermal is inputted in vivo, blood concentration is kept constant, therefore is being faced
Bed especially in terms of anxious, slow soft tissue injury with relatively broad.
Summary of the invention
The purpose of the present invention is to provide a kind of that there is the effect of activating microcirculation and removing stasis medicinal, relaxing muscles and tendons symplectic bone, it is used conveniently and safely
The external preparation and preparation method thereof for treating closed injury.
To achieve the above object, the invention adopts the following technical scheme:
A kind of external preparation for treating closed injury, is prepared by the raw material of following parts by weight:
Preferably, a kind of external preparation for treating closed injury, is prepared by the raw material of following parts by weight:
A kind of preparation method of external preparation that treating closed injury comprising following steps:
1) coptis, radix scutellariae, Cortex Phellodendri, rheum officinale, cattail pollen, Radix Notoginseng, lycopodium calvatum, deep is weighed by parts by weight of raw materials proportion
Nine kinds of grass, calamine medicinal materials, smashing and grinding, sieve with 100 mesh sieve, it is spare to obtain fine medicinal material powder；
2) it weighs after stearic acid, castor oil, liquid paraffin mix in container, is heated to by parts by weight of raw materials proportion
70-80 DEG C, add above-mentioned steps 1) obtained in fine medicinal material powder, stir to obtain oily phase while hot；
3) it weighs after triethanolamine, glycerol and distilled water mixes in another container, adds by parts by weight of raw materials proportion
Heat is to 70-80 DEG C of miscible water phase；
4) by above-mentioned steps 3) in water phase be slowly added in oily phase, it is stirring while adding, in 70-80 DEG C of stirring 0.5-0.8h
It emulsifies it completely, is cooled to room temperature to get the external preparation is arrived.
Speed of agitator is 2000rmin in the step 4)-1。
The invention adopts the above technical scheme, and the external preparation of the treatment closed injury is by the coptis, radix scutellariae, Huang
Cypress, rheum officinale assistant are formed with other a few herbs, have clearing and activating the channels and collaterals, the effect of swelling and pain relieving, and technical solution of the present invention takes greatly
The stasis of blood of the effects of yellow removing pattogenic heat from the blood and toxic material from the body, blood circulation promoting competent silt is anti-infective etc., the heat-clearing and damp-drying drug of Cortex Phellodendri, detumescence to acute or chronic soft tissue injury
The significant effect of the illnesss such as hemotoncus pain.Rheum officinale enters stomach, large intestine, Liver Channel, and expel the heat-evil poison, stagnant, the function of row hemostasis is broken, for hemostasis
Disease, that is, the benefits of taking the blood circulation promoting competent silt of rheum officinale, achieve the purpose that treat traumatic stasis swelling and pain.Cortex Phellodendri primary efficacy is heat-clearing and damp-drying drug, ancient
Also have burnt wet swollen record except it in nationality, such as " pearl sac " " Cortex Phellodendri has been used six: ..., except it is burnt wet swollen, three ".With medicine-feeding
Object composition prescription has the function of anti-inflammatory analgesic, activating blood circulation and reducing swelling, row stasis of blood promoting menstruation.The external preparation of present invention treatment closed injury
With relaxing tendons and activating collaterals, scattered stasis detumescence, anti-inflammatory analgetic eliminates fatigue, promotes to recycle unobstructed and other effects, embodies " outer disease is outer to be controlled "
" with apply generation clothes " traditional Chinese medicine administration features, and Chinese herbal medicine have low toxicity, low-residual be not likely to produce drug resistance with
, there is the advantage for the toxicity for avoiding liver first-pass effect and gastrointestinal tract in the advantages that dependence.Pharmacological evaluation shows that vulnerary dissipates
In the growth for having apparent inhibiting effect to inflammation swelling, promoting beneficial cells, meanwhile, it can continue to keep body swollen to inflammation
The reaction that capillary permeability increases when swollen, in this case, the phagocyte of human body itself can preferably gather damage
The position of wound swallows the bacterium of necrotic tissue, entrance, and the oedema of tissue can gradually disappear under good loop condition
It removing, the inflammatory cell infiltration of human body is lighter, and the reproduction reparation of own cells can be gone on smoothly, and after reparation, fibrous scar tissue is few,
More function is good after.
Specific embodiment
To deepen the understanding of the present invention, the invention will be further described combined with specific embodiments below, the embodiment
For explaining only the invention, it is not intended to limit the scope of the present invention..
A kind of external preparation for treating closed injury, is prepared by the raw material of following parts by weight:
A kind of preparation method of external preparation that treating closed injury comprising following steps:
1) coptis, radix scutellariae, Cortex Phellodendri, rheum officinale, cattail pollen, Radix Notoginseng, lycopodium calvatum, deep is weighed by parts by weight of raw materials proportion
Nine kinds of grass, calamine medicinal materials, smashing and grinding, sieve with 100 mesh sieve, it is spare to obtain fine medicinal material powder；
2) it weighs after stearic acid, castor oil, liquid paraffin mix in container, is heated to by parts by weight of raw materials proportion
70-80 DEG C, add above-mentioned steps 1) obtained in fine medicinal material powder, stir to obtain oily phase while hot；
3) it weighs after triethanolamine, glycerol and distilled water mixes in another container, adds by parts by weight of raw materials proportion
Heat is to 70-80 DEG C of miscible water phase；
4) by above-mentioned steps 3) in water phase be slowly added in oily phase, it is stirring while adding, in 70-80 DEG C of stirring 0.5-0.8h
It emulsifies it completely, is cooled to room temperature to get the external preparation is arrived.
Speed of agitator is 2000rmin in the step 4)-1。
Embodiment 1
A kind of preparation method of external preparation that treating closed injury comprising following steps:
1) 10 parts of the coptis is weighed by weight, 10 parts of radix scutellariae, 10 parts of Cortex Phellodendri, 10 parts of rheum officinale, 10 parts of cattail pollen, 3 parts of Radix Notoginseng, is stretched
Nine kinds of medicinal materials such as 10 parts of muscle grass, 10 parts of lopseed, 17 parts of calamine, smashing and grinding sieve with 100 mesh sieve, obtain fine medicinal material powder, spare；
2) weigh by weight 62 parts of stearic acid, 124 parts of castor oil, 124 parts of liquid paraffin in container mix after, heating
To 70-80 DEG C, add above-mentioned steps 1) obtained in fine medicinal material powder, stir to obtain oily phase while hot；
3) it weighs after 10 parts of triethanolamine, 62 parts of glycerol and 150 parts of distilled water mix in another container, adds by weight
Heat is to 70-80 DEG C of miscible water phase；
4) by above-mentioned steps 3) in water phase be slowly added in oily phase, it is stirring while adding, in 70-80 DEG C of stirring 0.5-0.8h
It emulsifies it completely, is cooled to room temperature to get the external preparation is arrived.
Speed of agitator is 2000rmin in the step 4)-1。
Embodiment 2
A kind of preparation method of external preparation that treating closed injury comprising following steps:
1) 5 parts of the coptis is weighed by weight, 5 parts of radix scutellariae, 5 parts of Cortex Phellodendri, 15 parts of rheum officinale, 15 parts of cattail pollen, 5 parts of Radix Notoginseng, stretches muscle
Nine kinds of medicinal materials such as 15 parts of grass, 15 parts of lopseed, 20 parts of calamine, smashing and grinding, sieve with 100 mesh sieve, obtain fine medicinal material powder, spare；
2) weigh by weight 60 parts of stearic acid, 120 parts of castor oil, 122 parts of liquid paraffin in container mix after, heating
To 70-80 DEG C, add above-mentioned steps 1) obtained in fine medicinal material powder, stir to obtain oily phase while hot；
3) it weighs after 8 parts of triethanolamine, 60 parts of glycerol and 100 parts of distilled water mix in another container, adds by weight
Heat is to 70-80 DEG C of miscible water phase；
4) by above-mentioned steps 3) in water phase be slowly added in oily phase, it is stirring while adding, in 70-80 DEG C of stirring 0.5-0.8h
It emulsifies it completely, is cooled to room temperature to get the external preparation is arrived.
Speed of agitator is 2000rmin in the step 4)-1。
Embodiment 3
A kind of preparation method of external preparation that treating closed injury comprising following steps:
1) 15 parts of the coptis is weighed by weight, 15 parts of radix scutellariae, 15 parts of Cortex Phellodendri, 5 parts of rheum officinale, 5 parts of cattail pollen, 2 parts of Radix Notoginseng, stretches muscle
Nine kinds of medicinal materials such as 5 parts of grass, 5 parts of lopseed, 15 parts of calamine, smashing and grinding, sieve with 100 mesh sieve, obtain fine medicinal material powder, spare；
2) weigh by weight 65 parts of stearic acid, 122 parts of castor oil, 120 parts of liquid paraffin in container mix after, heating
To 70-80 DEG C, add above-mentioned steps 1) obtained in fine medicinal material powder, stir to obtain oily phase while hot；
3) it weighs after 12 parts of triethanolamine, 65 parts of glycerol and 200 parts of distilled water mix in another container, adds by weight
Heat is to 70-80 DEG C of miscible water phase；
4) by above-mentioned steps 3) in water phase be slowly added in oily phase, it is stirring while adding, in 70-80 DEG C of stirring 0.5-0.8h
It emulsifies it completely, is cooled to room temperature to get the external preparation is arrived.
Speed of agitator is 2000rmin in the step 4)-1。
Embodiment 4
A kind of preparation method of external preparation that treating closed injury comprising following steps:
1) 12 parts of the coptis is weighed by weight, 8 parts of radix scutellariae, 7 parts of Cortex Phellodendri, 13 parts of rheum officinale, 11 parts of cattail pollen, 4 parts of Radix Notoginseng, stretches muscle
Nine kinds of medicinal materials such as 12 parts of grass, 12 parts of lopseed, 18 parts of calamine, smashing and grinding, sieve with 100 mesh sieve, obtain fine medicinal material powder, spare；
2) weigh by weight 63 parts of stearic acid, 122 parts of castor oil, 122 parts of liquid paraffin in container mix after, heating
To 70-80 DEG C, add above-mentioned steps 1) obtained in fine medicinal material powder, stir to obtain oily phase while hot；
3) it weighs after 12 parts of triethanolamine, 63 parts of glycerol and 180 parts of distilled water mix in another container, adds by weight
Heat is to 70-80 DEG C of miscible water phase；
4) by above-mentioned steps 3) in water phase be slowly added in oily phase, it is stirring while adding, in 70-80 DEG C of stirring 0.5-0.8h
It emulsifies it completely, is cooled to room temperature to get the external preparation is arrived.
Speed of agitator is 2000rmin in the step 4)-1。
The external preparation clinical observation experiment of test example treatment closed injury
1. clinical data
It has collected clinically using the external preparation for the treatment of closed injury obtained by the embodiment of the present invention 1,2,3,4
Service condition, each embodiment case 50 amount to 200, and case scenario is as follows:
2. relevant criterion
1. caput femoris necrosis is diagnosed according to " practical osteology ".There is apparent hip trauma history；No hip trauma history and have
Long-term Hormone, excessive drinking history etc.；Hip pain, based on adductor starting point, pain can be in duration or intermittence,
It can be radiated to knee joint downwards；Difficulty in walking, in walking lamely, progressive is aggravated；Hip joint function obstacle, based on inward turning, outreach,
Passive activity hip joint can have surrounding tissue cramp；All cases pass through comprehensive physical examination, clap X piece, CT and MRI check and
It makes a definite diagnosis.
2. acute soft tissue injury, including fascia, tendon, ligament and subcutaneous tissue, part muscle, joint capsule etc.；Office
Portion's tissue irritation, swelling, tenderness, muscle spasmus, dysfunction and skin burns etc.；X-ray inspection is without fracture.
3. treatment method
Using putting affected part outside external preparation ointment of the invention on the skin, one time 5 grams, 3 times a day；Weekly treatment 7 days, 4 Zhou Weiyi
A course for the treatment of does not use other anti-inflammatory analgetic stagnation resolvation drugs during treatment.
Observation index:
(1) severity extent assessment (point system)
1. pain: unbearably 3 points, 2 points can be born, hypodynia 1 divides.
2. swelling: > 1cm 3 divides, < 1cm~> 0.5cm 2 divides, < 0.5cm 1 divides with the comparison of strong side week diameter.
3. tenderness: light tenderness or tenderness 3 divides, tenderness is divided without tenderness 2, firmly tenderness 1 is divided.
4. muscle spasmus: as plate-like elastic disappear 3 points, poor flexibility 2 divide, slightly spasm elasticity can be 1 point.
5. dysfunction: joint motion is limited 30 ° 3 points of >, 20 ° 2 points of <, 10 ° 1 point of <.
6. skin burns: obvious scorching hot 3 points, moderate is 2 points scorching hot, low-grade fever 1 is divided.
(2) state of an illness indexes: 13~18 points of severe, 7~12 points of moderate, 1~6 point slight.
(3) curative effect judgment criteria
1. recovery from illness: symptom is completely disappeared with sign, and total mark is not more than 2 points after treatment.
2. effective: symptom is clearly better with sign, and total mark reduces 2/3 or more after treatment.
3. effectively: symptom and sign improve, and total mark reduces 1/3 or more after treatment.
4. invalid: symptom is not improved with sign, and total mark is reduced less than 1/3 after treatment.
4. treatment results
Treatment results are as follows:
5. conclusion
According to above-mentioned Clinical observation it is found that a kind of external preparation for treating closed injury of the present invention has relaxing muscles and tendons
Promoting blood circulation, scattered stasis detumescence, anti-inflammatory analgetic eliminate fatigue, promote to recycle unobstructed and other effects.Pharmacological evaluation shows external application system of the present invention
Agent ointment to inflammation swelling have apparent inhibiting effect, promote beneficial cells growth, meanwhile, can continue keep body right
The reaction that capillary permeability increases when inflammation swelling, in this case, the phagocyte of human body itself can preferably collect
The position for closing damage swallows the bacterium of necrotic tissue, entrance, and the oedema of tissue can be under good loop condition
It gradually eliminating, the inflammatory cell infiltration of human body is lighter, and the reproduction reparation of own cells can be gone on smoothly, after reparation, fibrous scar
Tissue is few, and rear function is good, and therefore, the present invention has substantive distinguishing features outstanding and significant progress.
Claims (4)
1. a kind of external preparation for treating closed injury, it is characterised in that: it is prepared by the raw material of following parts by weight:
5-15 parts of Cortex Phellodendri of 5-15 portions of radix scutellariae of 5-15 parts of the coptis
2-5 parts of Radix Notoginseng of 5-15 portions of cattail pollen of 5-15 parts of rheum officinale
15-20 parts of calamine of 5-15 parts of lopseed of 5-15 portions of lycopodium calvatum
120-124 parts of liquid paraffin of 120-124 parts of castor oil of 60-65 parts of stearic acid
100-200 parts of distilled water of 8-12 parts of triethanolamine of 60-65 parts of glycerol.
2. a kind of external preparation for treating closed injury according to claim 1, it is characterised in that: it is by following weight
The raw material of part is prepared:
10 parts of the coptis, 10 parts of Cortex Phellodendri of 10 portions of radix scutellariae
10 parts of rheum officinale, 3 parts of Radix Notoginseng of 10 portions of cattail pollen
10 portions of lycopodium calvatum, 17 parts of calamine of 10 parts of lopseed
62 parts of stearic acid, 124 parts of liquid paraffin of 124 parts of castor oil
62 parts of glycerol, 150 parts of distilled water of 10 parts of triethanolamine.
3. a kind of preparation method of the external preparation for the treatment of closed injury as claimed in claim 1 or 2, it is characterised in that:
Itself the following steps are included:
1) coptis, radix scutellariae, Cortex Phellodendri, rheum officinale, cattail pollen, Radix Notoginseng, lycopodium calvatum, lopseed, furnace are weighed by parts by weight of raw materials proportion
Gan Shijiu kind medicinal material, smashing and grinding, sieves with 100 mesh sieve, it is spare to obtain fine medicinal material powder；
2) it is weighed after stearic acid, castor oil, liquid paraffin mix in container by parts by weight of raw materials proportion, is heated to 70-
80 DEG C, add above-mentioned steps 1) obtained in fine medicinal material powder, stir to obtain oily phase while hot；
3) it weighs after triethanolamine, glycerol and distilled water mixes in another container, is heated to by parts by weight of raw materials proportion
70-80 DEG C of miscible water phase；
4) by above-mentioned steps 3) in water phase be slowly added in oily phase, it is stirring while adding, make it in 70-80 DEG C of stirring 0.5-0.8h
Emulsification completely is cooled to room temperature to get the external preparation is arrived.
4. a kind of preparation method of external preparation for treating closed injury according to claim 3, it is characterised in that: institute
Stating speed of agitator in step 4) is 2000 rmin-1。
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Citations (1)
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|---|---|---|---|---|
| CN1173356A (en) * | 1997-07-02 | 1998-02-18 | 陈运祥 | Method for prepn. of Chinese medicinal external application ointment for diminishing inflammation, stopping pain and setting fracture |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1173356A (en) * | 1997-07-02 | 1998-02-18 | 陈运祥 | Method for prepn. of Chinese medicinal external application ointment for diminishing inflammation, stopping pain and setting fracture |
Non-Patent Citations (3)
| Title |
|---|
| 中药促进软组织损伤修复的临床研究进展;佃仁森等;《中国中医骨伤科杂志》;20080331;第16卷(第3期);第68-72页 |
| 中药促进软组织损伤修复的动物实验模型与组织形态实验研究;佃仁森等;《中医正骨》;20080731;第20卷(第7期);第72-74页 |
| 五黄汤加减治疗关节外伤;刘成斌;《山东中医杂志》;19961231;第15卷(第8期);第379页 |
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