CN110302271B

CN110302271B - Cape jasmine capable of dispelling cold and preparation method thereof

Info

Publication number: CN110302271B
Application number: CN201910659531.4A
Authority: CN
Inventors: 汤智; 谢宏赞; 王兴
Original assignee: Individual
Current assignee: XIANGTAN HOSPITAL OF CHINESE MEDICINE
Priority date: 2019-07-22
Filing date: 2019-07-22
Publication date: 2022-03-22
Anticipated expiration: 2039-07-22
Also published as: CN110302271A

Abstract

The embodiment of the invention provides gardenia jasminoides atraumatic and a preparation method thereof. The wound-removing liquid has the effects of clearing away heat and toxic materials, promoting blood circulation, removing blood stasis, relieving swelling and pain, and treating limb injury, swelling and pain accompanied by burning heat and red swelling, and through long-term clinical observation, the wound-removing liquid is decocted with water for wet compress by the above prescription, so that a good curative effect is obtained, and the problem of unsatisfactory curative effect of the external application plaster for acute soft tissue injury in the prior art is solved. The embodiment of the invention also provides a preparation method of the gardenia jasminoides atraumatic.

Description

Cape jasmine capable of dispelling cold and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to gardenia jasminoides atraumatic and a preparation method thereof.

Background

Acute soft tissue injury is the most common and prevalent disease in orthopedics and traumatology, with a very high incidence. Acute soft tissue injury refers to acute closed injury of muscles, ligaments, fascia, tendon sheaths, articular cartilage, joint capsules, synovial capsules and other parts caused by various violence on the body. Clinically, it is usually manifested as pain, ecchymosis, swelling, and limited movement. Acute soft tissue injury brings great pain to patients, the injury can influence venous return and artery blood supply, and affected limbs cannot obtain sufficient nutrition and blood supply, so that the treatment research of the acute soft tissue injury has an important role.

Modern medicine believes that acute soft tissue injury, swelling, is caused by trauma leading to bleeding due to capillary vessel rupture and increased permeability of the vessel wall, extravasation of intravascular fluid into interstitial spaces. Pain is due to traumatic hematomas or inflammatory reactions that stimulate local peripheral nerves. The tissue ischemia and hypoxia caused by aseptic inflammation caused by closed tissue wound aggravate the deformation necrosis and blood stasis of the tissue cell.

The treatment of acute soft tissue injury is divided into oral administration and external treatment.

For oral administration, the non-steroidal anti-inflammatory drugs, the dehydration and diuresis and the PIRCE treatment can play a role in symptomatic treatment of red swelling and pain caused by acute soft tissue injury, have good curative effect, and can achieve the anti-inflammatory effect by inhibiting the synthesis of interleukin-6, but the drugs have certain toxic and side effects including toxic and side effects on visceral systems: damage to the kidney, development of hematuria, proteinuria and renal dysfunction; liver damage, jaundice, increased transaminase, etc.; toxic and side effects on the nervous system: common symptoms comprise headache, dizziness, tinnitus, insomnia and the like; and toxic and side effects on the blood system: reducing granulocyte can reduce immunity, and can affect erythropoiesis to produce aplastic anemia.

For external treatment, external application of traditional Chinese medicine is mainly used, although literature research and clinical experience prove that traditional Chinese medicine has obvious curative effect and obvious advantages in the aspect of treating acute soft tissue injury. However, in the process of implementing the embodiment of the present application, the inventor of the present application finds that the existing external application plaster has various external dosage forms and is not ideal in drug treatment.

Therefore, there is still a need for an effective and safe external preparation.

Disclosure of Invention

The gardenia jasminoides ellis disclosed by the embodiment of the invention has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, and relieving swelling and pain, and is mainly used for treating limb injuries, swelling and pain accompanied with burning heat and red swelling. Through long-term clinical observation, the plaster is decocted with water and applied in a wet way by using the prescription, so that a good curative effect is obtained, and the problem that the curative effect of the externally applied plaster for treating acute soft tissue injury in the prior art is not ideal is solved. The embodiment of the invention also provides a preparation method of the gardenia jasminoides atraumatic.

The gardenia jasminoides atraumatic comprises the following components in parts by weight:

10-50 parts of coptis root,

10-50 parts of phellodendron amurense,

10-50 parts of rhubarb, the balance being,

5-25 parts of frankincense,

50-200 parts of water.

Preferably, the composition comprises the following components in parts by weight:

20-40 parts of coptis root,

20-40 parts of phellodendron amurense,

20-40 parts of rhubarb, namely rhubarb,

10-20 parts of frankincense, wherein the frankincense,

50-200 parts of water.

Further preferably, the composition comprises the following components in parts by weight:

30 parts of coptis root, rhizoma coptidis,

30 parts of phellodendron amurense, namely,

30 parts of rhubarb, the root of which is rhubarb,

15 parts of frankincense, wherein the frankincense,

50-150 parts of water.

Still more preferably, the composition further comprises the following components in parts by weight:

10-50 parts of cape jasmine fruit,

5-25 parts of myrrh.

10-60 parts of cortex moutan,

5-25 parts of safflower.

5-15 parts of mint,

5-15 parts of alum,

25-100 parts of honey.

The preparation method of the gardenia jasminoides atraumatic comprises the following steps: weighing the components according to the proportion, adding the components into water, and decocting to obtain the traditional Chinese medicine.

Preferably, the preparation method of the gardenia jasminoides atraumatic comprises the following steps: weighing the components according to the proportion, adding the components into water, decocting to obtain liquid medicine, simultaneously boiling honey, cooling to obtain honey water, and mixing the honey water and the liquid medicine according to the mass ratio of 1:2 to obtain the honey oral liquid.

Preferably, the time for decoction is greater than 0.5 h.

The application method of the gardenia jasminoides ellis for removing the wound water comprises the steps of soaking the gardenia jasminoides ellis in gauze and directly applying the gauze externally.

The traditional Chinese medicine external plaster in the prior art has various external dosage forms, and the treatment and treatment effects of the medicine are different. The links of processing and preparation of the medicine directly influence the treatment effect and adverse reaction of the medicine. The gardenia jasminoides atraumatic provided by the embodiment of the invention does not need a special medicinal material processing process, has a simple preparation method, and avoids possible adverse effects on the therapeutic effect caused by links such as processing and processing of medicaments.

At the early stage of fracture and soft tissue injury, blood vessels are damaged and overflow outside at the early stage of injury, blood stasis and heat are accumulated and transformed, and local red, swelling, heat and pain appear. This type is the most common of excess syndrome, heat syndrome and yang syndrome, and refers to the syndrome of intermingled blood stasis and heat.

The gardenia jasminoides and cape jasmine cold-dispelling formula disclosed by the embodiment of the invention is high in heat-clearing and blood-cooling power, and is combined with components for promoting blood circulation, removing blood stasis, relieving pain, and removing dampness and relieving itching through skin. Rhubarb, coptis, phellodendron and gardenia are monarch drugs which can clear heat, dry dampness, purge fire and detoxify in the wound-removing water; cortex moutan has effects of clearing heat and cooling blood, Olibanum and Myrrha has effects of promoting blood circulation and relieving swelling, removing blood stasis and relieving pain, and Carthami flos has effects of promoting blood circulation and removing blood stasis as ministerial drug; peppermint has the effects of dispelling the evil in the superficies, promoting eruption and promoting the circulation of qi, alum has the effects of eliminating dampness and relieving itching, and detoxifying and killing parasites, and are used as adjuvant drugs together. The application of the gardenia jasminoides rheumatism-eliminating plaster in the orthopedics and traumatology has definite curative effect, takes the treatment methods of clearing heat and detoxicating, promoting blood circulation and removing blood stasis, and relieving swelling and pain as treatment methods, and belongs to the field of simultaneous treatment of different diseases.

The traditional Chinese medicine for external treatment of trauma has long history, and ancient people often cause trauma such as fracture and the like in the process of fighting with various factors in the nature, so that the people learn to use leaves, grass stems, mineral powder and the like to coat wounds and wounds so as to relieve pain or stop bleeding, and gradually find external medicines with the effects of stopping bleeding, relieving pain, diminishing swelling, expelling pus, promoting tissue regeneration and healing sore, while the current external medicines mainly comprise dressing, ointment, plaster, medicinal powder, wine and oil, and a method for treating acute trauma by using water-decoction wet dressing is not available, and a method for treating acute trauma by using water-decoction honey wet dressing is not available. Compared with the dressing, ointment, plaster, medicinal powder and wine blended oil, the wet dressing by decocting with water has the advantage of no adverse reaction on skin.

The embodiment of the invention has the beneficial effects

1. The embodiment of the invention provides gardenia jasminoides atraumatic, which has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, and relieving swelling and pain, is mainly used for treating limb injuries, swelling and pain accompanied by burning heat and red swelling, and through long-term clinical observation, the gardenia jasminoides atraumatic is applied by water decoction in the above prescription in a wet manner, so that a good curative effect is obtained, and the problem that the treatment effect of an external application plaster for acute soft tissue injury in the prior art is not ideal is solved;

2. the embodiment of the invention also provides a preparation method of the gardenia jasminoides atraumatic, which does not need a special medicinal material processing process, has a simple preparation method, and avoids possible adverse effects on treatment effects caused by links such as processing and processing of medicaments.

Detailed Description

In order to better understand the above technical solutions, the above technical solutions will be described in detail with reference to specific embodiments.

Example 1

30 parts of coptis chinensis, 30 parts of golden cypress, 30 parts of rheum officinale, 15 parts of frankincense and 100 parts of water.

Example 2

20 parts of coptis chinensis, 20 parts of golden cypress, 20 parts of rheum officinale, 10 parts of frankincense and 50 parts of water.

Example 3

40 parts of coptis chinensis, 40 parts of golden cypress, 40 parts of rheum officinale, 20 parts of frankincense and 200 parts of water.

Example 4

30 parts of coptis chinensis, 30 parts of golden cypress, 30 parts of rheum officinale, 15 parts of frankincense, 10 parts of cape jasmine fruit, 15 parts of myrrh, 25 parts of cortex moutan, 15 parts of safflower, 9 parts of mint, 9 parts of alum and 100 parts of water.

Example 5

30 parts of coptis chinensis, 30 parts of golden cypress, 30 parts of rheum officinale, 15 parts of frankincense, 10 parts of cape jasmine fruit, 5 parts of myrrh, 10 parts of cortex moutan, 5 parts of safflower carthamus, 5 parts of mint, 5 parts of alum and 100 parts of water.

Example 6

30 parts of coptis chinensis, 30 parts of golden cypress, 30 parts of rheum officinale, 15 parts of frankincense, 50 parts of cape jasmine fruit, 25 parts of myrrh, 60 parts of cortex moutan, 25 parts of safflower, 15 parts of mint, 15 parts of alum, 50 parts of honey and 100 parts of water.

Example 7

The embodiment provides a preparation method of gardenia jasminoides atraumatic, which comprises the following steps: weighing the components according to the proportion, adding the components into water, and decocting to obtain the traditional Chinese medicine.

The decoction time is more than 0.5 h.

Example 8

The embodiment provides a using method of gardenia jasminoides for removing the wound fluid, which comprises the following steps: directly applying the medicine externally after being soaked by gauze.

Example of detection

In 2018, 6-12 months, the number of cases in the group is 80, 50 men and 30 women. The age is 18-60 years, and the average age is 40 years. In 44 cases, traffic accidents, in 18 cases, daily life falls and in 18 cases sports injuries. The upper limb 24 cases and the lower limb 58 cases. Acute closed soft tissue injury was reported in all cases.

Diagnostic criteria

Diagnostic criteria of traditional Chinese medicine

Refer to the 'Chinese medicine injury science' and 'clinical research guidance principle of new Chinese medicine for treating soft tissue injury' for specification.

Syndrome of qi stagnation and blood stasis:

the main symptoms are: local swelling, stabbing pain, localized pain, bluish purple ecchymosis or large hematoma, local skin temperature rise, and functional activity limitation of the affected limb.

The secondary symptoms are as follows: the tongue is purple dark or with ecchymosis, and the pulse is wiry and unsmooth.

Tongue pulse: the tongue is reddish or pale; the coating of the tongue is thin or thin white or thin yellow; the pulse or deep and thready.

And (3) diagnosis: history of trauma; has 2 main symptoms; or one major symptom and any minor symptom; the tongue and pulse can be synthesized for diagnosis.

Standard of Western diagnosis

The prescription refers to the clinical research guiding principle of the new Chinese medicine for treating the soft tissue injury.

(1) Has obvious history of trauma, severe pain, rapid local swelling and limb movement dysfunction;

(2) the tenderness of the wound is obvious, local bluish purple ecchymosis can occur, subcutaneous hematoma can occur in severe cases, and wave sign is positive;

(3) auxiliary inspection: the X-ray examination mainly eliminates fracture, dislocation, bone disease and the like; the MRI examination excludes ligament rupture injuries that are combined with surgical repair treatments.

Inclusion criteria were:

(1) those who meet the above-mentioned Western diagnosis standards and Chinese medicine syndrome diagnosis standards;

(2) the time of the visit is less than or equal to 48 hours from the time of the disease onset;

(3) patients are 18 years old and 65 years old and younger.

Exclusion criteria:

(1) those who do not meet the above-mentioned Western diagnosis standard or Chinese syndrome diagnosis standard;

(2) allergic constitution or allergic to pharmaceutical ingredients;

(3) the lesion is accompanied by an open wound.

Termination criteria for the study:

(1) patients who fail to insist on taking medicine according to the medical advice or change other medicines for treatment by themselves in the experiment;

the patients who have local skin discomfort in the experiment can not continue the treatment.

Method of treatment

A clinical random control test method is adopted, 80 study objects are randomly divided into gardenia vulnerary treatment combination control groups by a random digital table method according to the sequence of treatment, and clinical effect observation is carried out.

Treatment groups: according to the formula provided in example 5, the preparation method and the use method provided in examples 7 and 8 are adopted, the gardenia jasminoides atraumatic is continuously applied to the swelling part of the patient for 2 times per day, and the control group does not use any externally applied swelling and pain relieving medicine.

At the same time, the two groups use the same oral medicine, physical therapy and the like as basic treatment. The oral medicine mainly comprises Chinese medicinal materials of Chinese clinopodium herb, and 3 tablets per day. Observing and recording the clinical change and skin irritation before treatment and on days 1, 3 and 7, and if local adverse reaction occurs, immediately treating or stopping administration and recording.

Observation index and evaluation criterion

Clinical symptom score:

swelling scoring: and (3) comparing the data with the healthy side by adopting a delay marking method, measuring the circumference of the limb by taking the most obvious swelling position of the injured limb as a center, measuring two groups of affected limbs each time, calculating swelling conditions in different time periods, and recording the score. No swelling (score 0) of the affected area; the tissues are slightly swollen, the skin texture is slightly shallow, and the circumference of the limb is 0.5-1 cm (2 minutes) larger than that of the healthy side; the swelling is obvious, the skin texture is obviously lightened, and the circumference of the limb is 1.1-2.0 cm (4 minutes) larger than that of the healthy side; severe swelling, shiny epidermis, disappearance of skin texture, even tension blisters, limb circumference greater than 2.1cm (6 minutes) from healthy side. The raw data was recorded from the time of admission to the patient and recorded immediately, first, third and seven days of admission, respectively.

Pain scoring: there are many methods for evaluating and quantifying pain subjects clinically, and the Visual Analogue Scale (VAS) is the most common and easy method in clinical research at present, and the VAS method can more intuitively and sensitively reflect the pain change process and the pain alleviation or aggravation degree. In the clinical practice, the VAS card is generally adopted and is classified into a line graph, the larger the number is, the higher the pain intensity is, and the two ends of the card are respectively marked with 'no pain (0)' and 'most severe pain (10)'. The patient is told to accurately assess his or her pain using a mechanism for explaining pain development, a method of presentation and a method of use to the patient. VAS evaluation criteria: no pain is scored at 0, and slight pain is scored at 1-4; 5-6 divided into moderate pain; 7-9 are classified as severe pain; 10 is classified as severe pain. Initial data was also recorded from the time of patient admission and data was recorded on the first, third and seven days post-treatment, respectively.

Joint function scoring: the joint function of the negative electrode of the injured part was evaluated (using JOA joint function evaluation method), and the data was recorded from the time of admission of the patient, and the observation data was recorded on the first, third, and seventh days after the treatment.

The standard of cure is as follows: both the local pain VAS score and the swelling score were 0 points; or a reduction of more than 12 points from total pre-treatment score; or the joint function is 80-100 minutes, or is reduced by less than 20 minutes before treatment.

The obvious effect standard is as follows: the VAS score of the local pain is 1-4, and the swelling score is 2; or the total score is reduced by 8-12 points compared with the total score before treatment; or the joint function is 60-80 minutes, or is reduced by less than 40 minutes before treatment.

The effective standard is as follows: the VAS score of local pain is 5-6 points, and the swelling score is 4 points; or the total score is reduced by 4-8 points compared with the total score before treatment; or the joint function is 40-60 minutes, or is reduced by less than 60 minutes before treatment.

Invalidation criteria: the VAS score of local pain is 7-10 points, and the swelling score is 6 points; or the total score is reduced by 0-4 points compared with the total score before treatment; or the joint function is less than 40 points, or is reduced by more than 60 points compared with before treatment.

Statistical analysis

All data are analyzed and processed on the computer by the software package SPSS15.0 version, and data are measured to

Showing, inter-group comparisons with t-tests, statistical analysis of categorical variable data by X²And (6) checking.

40 cases of the treatment group and 40 cases of the control group. The difference in lesion site, age, gender was not statistically significant (p >0.05) in both groups, suggesting that both groups were equally comparable.

The two groups of therapeutic effects after treatment are compared in Table 1

TABLE 1 comparison of the two groups of therapeutic effects after treatment

Group of	N	Cure of disease	Show effect	Is effective	Invalidation	Total number of effective cases
							Treatment group	40	30	6	3	1	39(97.5％)
Control group	40	14	7	7	12	28(70％)

The statistical analysis of the two groups of data is carried out by using SPSS15.0 statistical software, the total effective rates of the two groups are significantly different (p is less than 0.05), and the treatment group is significantly better than the control group.

Claims

1. The gardenia jasminoides atraumatic is characterized by being prepared from the following raw materials in parts by weight:

30 parts of coptis root, rhizoma coptidis,

30 parts of phellodendron amurense, namely,

30 parts of rhubarb, the root of which is rhubarb,

15 parts of frankincense, wherein the frankincense,

50-150 parts of water

10-50 parts of cape jasmine fruit,

5-25 parts of myrrh, namely myrrh,

10-60 parts of cortex moutan,

5-25 parts of safflower, wherein the safflower is selected from the group consisting of safflower, and safflower powder, wherein the extract, safflower is used as raw materials, wherein the extract, safflower is used as raw materials, and safflower, wherein the extract, safflower is used as raw materials, added by weight parts by weight are 5-25 parts by weight parts, 5-25 parts by weight parts,

5-15 parts of mint,

5-15 parts of alum,

25-100 parts of honey, namely,

the preparation method of the gardenia vulnerary comprises the following steps: weighing the components except honey according to a ratio, adding the components into water, decocting to obtain liquid medicine, boiling the honey, cooling to obtain honey water, and mixing the honey water and the liquid medicine according to a mass ratio of 1:2 to obtain the honey beverage.

2. The gardenia atraumatic solution of claim 1, wherein the decoction time is more than 0.5 h.