CN104815090A - External preparation for treating closed injury and preparation method thereof - Google Patents
External preparation for treating closed injury and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an external preparation for treating closed injury and a preparation method thereof. The method comprises the following steps: (1) weighing the following nine medical materials in parts by weight: Coptis chinensis, Scutellaria baicalensis, golden cypress, rheum officinale, pollen typhae, pseudo-ginseng, lycopodium clavatum, garden balsam stem and calamine, smashing and grinding, and sieving with a 100-mesh sieve to obtain the medical material fine powder for later use; (2) weighing stearic acid, castor oil and liquid paraffin, mixing in a container, heating to the temperature of 70-80 DEG C, adding the medical material fine powders, and stirring while the mixture is hot, so as to obtain the oil phase; (3) weighing triethanolamine, glycerinum and distilling water, mixing in another container, heating to the temperature of 70-80 DEG C, and mixing to obtain the water phase; (4) slowly adding the water phase into the oil phase, adding while stirring at the temperature of 70-80 DEG C, fully emulsifying, and cooling to room temperature to obtain the external preparation. The external preparation prepared by the invention has the functions of relaxing the muscles, stimulating the blood circulation, diminishing swelling, eliminating stagnant blood, diminishing inflammation, stopping pain, eliminating fatigue and promoting circulation. Simultaneously the capillary permeability increase reaction on the organism for the inflammatory swelling can be kept, the inflammatory cell infiltration on the organism is slight, the reproduction repair of the self cell is smooth and the function after healing is good.
Description
Technical field
The present invention relates to technical field of Chinese medicine, be specifically related to a kind of external preparation for the treatment of closed injury and preparation method thereof.
Background technology
Fracture, dislocation, osteonecrosis, soft tissue injury caused by bruise are in the dialectical middle subordination of orthopedics and traumatology of Chinese medicine in the category of " muscle and tendon injury ", and a lot of ancient doctor's nationality has very detailed discussion.Huangdi's Internal Classics just has a lot of record, as " generation of Plain Questions the five internal organs " is just recorded: " all muscle persons, all belong to joint." muscle is born in bone, be in relation between joint." a Plain Questions paralysis opinion section " with: " penis main beam bone and sharp joint are also." vividly describe the function of muscle, namely muscle has constraint joint and joint flexion-extension motion is acted on flexibly; " the large opinion of Plain Questions YIN YANG classification of natural phenomena " is pointed out: " impairment of QI resulting in pain ", " injury of configuration resulting in swelling ", thinks first pain then swollen person, and impairment of QI resulting in injury of the configuration also; First swollen then pain person, is injury of configuration resulting in impairment of QI.When human body is subject to external force fight, blood vessels meridians are dampened, and vim and vigour running is not smooth, and meridians muscle arteries and veins mechanism of qi lattice hinder, stagnation of QI and blood may bring about pain, and the opinion having " all pains are shot a glance at and are born in gas ".When gas is injured, Local Block, battalion defends not all right, and mechanism of qi is inaccessible, and hematogenous blockage will form addiction blood, namely so-called " qi as the commander of blood "." stagnation of QI blood addiction, blood oozing from the body openings or subcuta neous tissue arteries and veins are outer, venation is obstructed " is the pathogenesis understanding of motherland's medical science to the soft tissue injury (injury of tendon and muscle) caused by fracture, dislocation, bruise.The fundamentum of Chinese traditional treatment traumatology pain disease is promoting flow of QI and blood, eliminating blood stasis and smoothing collaterals, and according to the body constitution giving treatment in accordance with the patient’s individuality of patient coordinate dispel the wind, cold expelling, dehumidifying, heat clearing away and relax through dredging collateral, benefiting QI and nourishing blood, take a tonic or nourishing food to build up one's health Liver and kidney method etc.
Western medical treatment fracture and soft tissue injury often adopt the fixing method of braking in local, but extenal fixation braking not only brings misery to patient for a long time, and affect the blood circulation of local especially and make wound healing less effective.When damaging generation, soft tissue injury usually exists with fracture simultaneously, therefore positive treatment fracture and soft tissue injury of far-reaching significance, otherwise not only can best opportunity of delay treatment, and the healing effect of fracture can be affected, even cause fracture delayed healing and even disunion etc.
Modern medicine proves, percutaneous dosing is a kind of simple and effective administering mode, and uses Chinese medicine to carry out washout or external application, after medicine and contact skin, large portion enters medicine-feeding part by skin, is playing drug effect in local, a part of medicine can enter blood circulation simultaneously, plays a role at whole body.Percutaneous dosing has 3 large advantages: medicine is subject to the impact of liver and gastrointestinal " first pass effect " hardly, and utilization ratio of drug is high, can reduce the infringement to stomach, liver; The degraded of medicine in liver or gastrointestinal tract or inactivation can be avoided; Can speed on demand input in body by drug transdermal, blood drug level keeps constant, therefore comparatively extensive in clinical utilization particularly in anxious, slow soft tissue injury.
Summary of the invention
The object of the present invention is to provide a kind of effect with blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons symplectic bone, external preparation of safe treatment closed injury easy to use and preparation method thereof.
For achieving the above object, the present invention is by the following technical solutions:
Treat an external preparation for closed injury, it comprises the raw material of following weight portion:
Preferably, a kind of external preparation for the treatment of closed injury, it comprises the raw material of following weight portion:
Treat a preparation method for the external preparation of closed injury, it comprises the following steps:
1) take Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, Pollen Typhae, Radix Notoginseng, Herba Lycopodii, Herba speranskiae tuberculatae, Calamina nine kinds of medical materials by described parts by weight of raw materials proportioning, pulverize grinding, cross 100 mesh sieves, obtain fine medicinal material powder for subsequent use;
2) take after stearic acid, Oleum Ricini, liquid Paraffin mix in container by described parts by weight of raw materials proportioning, be heated to 70-80 DEG C, then add above-mentioned steps 1) in the fine medicinal material powder of gained, stir to obtain oil phase while hot;
3) take after triethanolamine, glycerol and distilled water mix in another container by described parts by weight of raw materials proportioning, be heated to 70-80 DEG C of miscible aqueous phase;
4) by above-mentioned steps 3) in aqueous phase slowly add in oil phase, limit edged stir, 70-80 DEG C stir 0.5-0.8h make its complete emulsifying, be cooled to room temperature, namely obtain described external preparation.
Described step 4) in speed of agitator be 2000rmin
-1.
The present invention adopts above technical scheme, the external preparation of described treatment closed injury is helped formed with other a few herbs by Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, have and restore menstrual flow and invigorate blood circulation, the effect of reducing swelling and alleviating pain, technical scheme of the present invention gets Radix Et Rhizoma Rhei removing pathogenic heat from blood and toxic substance from the body, blood circulation promoting competent silt, infection etc., the effect such as heat clearing and damp drying, detumescence of Cortex Phellodendri is to the Be very effective of the diseases such as the swelling and pain due to blood stasis of acute or chronic soft tissue injury.Radix Et Rhizoma Rhei enters stomach, large intestine, Liver Channel, and expel the heat-evil poison, and removing mass is stagnant, the merit of clots absorbing blood, and for blood stasis disease, the effect of namely getting the blood circulation promoting competent silt of Radix Et Rhizoma Rhei reaches the object for the treatment of traumatic stasis and swelling and ache.Cortex Phellodendri primary efficacy is heat clearing and damp drying, also has the record of burnt damp-edema except it in ancient books, as " pearl sac " " Cortex Phellodendri with having six: ..., except burnt damp-edema, three also ".The effect that above medicine composition prescription has anti-inflammatory analgesic, promoting blood circulation and detumescence, clots absorbing stimulate the menstrual flow.The external preparation that the present invention treats closed injury has relaxing muscles and tendons to promote blood circulation, detumescence dissipating blood stasis, anti-inflammatory analgetic, allaying tiredness, impel circulation effect such as unobstructed, embody the administration features of motherland's traditional medicine of " outer sick external treatment " " taking with deposited generation ", and Chinese herbal medicine has low toxicity, low-residual not easily produces the advantage such as drug resistance and dependency, has the advantage avoiding liver first-pass effect and gastrointestinal toxicity.Pharmacological evaluation shows, vulnerary is dispersed in has obvious inhibitory action to inflammation swelling, promote the growth of beneficial cells, simultaneously, can continue to keep body in the reaction of increasing capillary permeability during inflammation swelling, in this case, the phagocyte of human body self can better gather the position of damage, to slough, the antibacterial entered engulfs, the edema of tissue can be eliminated gradually under good loop condition, the inflammatory cell infiltration of human body is lighter, the reproduction reparation of own cells can be carried out smoothly, after reparation, fibrous scar tissue is few, more after, function is good.
Detailed description of the invention
For deepening the understanding of the present invention, below in conjunction with specific embodiment, the invention will be further described, and this embodiment only for explaining the present invention, does not form limiting the scope of the present invention.
Treat an external preparation for closed injury, it comprises the raw material of following weight portion:
Treat a preparation method for the external preparation of closed injury, it comprises the following steps:
1) take Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, Pollen Typhae, Radix Notoginseng, Herba Lycopodii, Herba speranskiae tuberculatae, Calamina nine kinds of medical materials by described parts by weight of raw materials proportioning, pulverize grinding, cross 100 mesh sieves, obtain fine medicinal material powder for subsequent use;
2) take after stearic acid, Oleum Ricini, liquid Paraffin mix in container by described parts by weight of raw materials proportioning, be heated to 70-80 DEG C, then add above-mentioned steps 1) in the fine medicinal material powder of gained, stir to obtain oil phase while hot;
3) take after triethanolamine, glycerol and distilled water mix in another container by described parts by weight of raw materials proportioning, be heated to 70-80 DEG C of miscible aqueous phase;
4) by above-mentioned steps 3) in aqueous phase slowly add in oil phase, limit edged stir, 70-80 DEG C stir 0.5-0.8h make its complete emulsifying, be cooled to room temperature, namely obtain described external preparation.
Described step 4) in speed of agitator be 2000rmin
-1.
Embodiment 1
Treat a preparation method for the external preparation of closed injury, it comprises the following steps:
1) take nine kinds of medical materials such as Rhizoma Coptidis 10 parts, Radix Scutellariae 10 parts, Cortex Phellodendri 10 parts, Radix Et Rhizoma Rhei 10 parts, Pollen Typhae 10 parts, Radix Notoginseng 3 parts, Herba Lycopodii 10 parts, Herba speranskiae tuberculatae 10 parts, Calamina 17 parts by weight, pulverize grinding, cross 100 mesh sieves, obtain fine medicinal material powder, for subsequent use;
2) take after stearic acid 62 parts, Oleum Ricini 124 parts, liquid Paraffin 124 parts mix in container by weight, be heated to 70-80 DEG C, then add above-mentioned steps 1) in the fine medicinal material powder of gained, stir to obtain oil phase while hot;
3) take after triethanolamine 10 parts, glycerol 62 parts and distilled water 150 parts mix in another container by weight, be heated to 70-80 DEG C of miscible aqueous phase;
4) by above-mentioned steps 3) in aqueous phase slowly add in oil phase, limit edged stir, 70-80 DEG C stir 0.5-0.8h make its complete emulsifying, be cooled to room temperature, namely obtain described external preparation.
Described step 4) in speed of agitator be 2000rmin
-1.
Embodiment 2
Treat a preparation method for the external preparation of closed injury, it comprises the following steps:
1) take nine kinds of medical materials such as Rhizoma Coptidis 5 parts, Radix Scutellariae 5 parts, Cortex Phellodendri 5 parts, Radix Et Rhizoma Rhei 15 parts, Pollen Typhae 15 parts, Radix Notoginseng 5 parts, Herba Lycopodii 15 parts, Herba speranskiae tuberculatae 15 parts, Calamina 20 parts by weight, pulverize grinding, cross 100 mesh sieves, obtain fine medicinal material powder, for subsequent use;
2) take after stearic acid 60 parts, Oleum Ricini 120 parts, liquid Paraffin 122 parts mix in container by weight, be heated to 70-80 DEG C, then add above-mentioned steps 1) in the fine medicinal material powder of gained, stir to obtain oil phase while hot;
3) take after triethanolamine 8 parts, glycerol 60 parts and distilled water 100 parts mix in another container by weight, be heated to 70-80 DEG C of miscible aqueous phase;
4) by above-mentioned steps 3) in aqueous phase slowly add in oil phase, limit edged stir, 70-80 DEG C stir 0.5-0.8h make its complete emulsifying, be cooled to room temperature, namely obtain described external preparation.
Described step 4) in speed of agitator be 2000rmin
-1.
Embodiment 3
Treat a preparation method for the external preparation of closed injury, it comprises the following steps:
1) take nine kinds of medical materials such as Rhizoma Coptidis 15 parts, Radix Scutellariae 15 parts, Cortex Phellodendri 15 parts, Radix Et Rhizoma Rhei 5 parts, Pollen Typhae 5 parts, Radix Notoginseng 2 parts, Herba Lycopodii 5 parts, Herba speranskiae tuberculatae 5 parts, Calamina 15 parts by weight, pulverize grinding, cross 100 mesh sieves, obtain fine medicinal material powder, for subsequent use;
2) take after stearic acid 65 parts, Oleum Ricini 122 parts, liquid Paraffin 120 parts mix in container by weight, be heated to 70-80 DEG C, then add above-mentioned steps 1) in the fine medicinal material powder of gained, stir to obtain oil phase while hot;
3) take after triethanolamine 12 parts, glycerol 65 parts and distilled water 200 parts mix in another container by weight, be heated to 70-80 DEG C of miscible aqueous phase;
4) by above-mentioned steps 3) in aqueous phase slowly add in oil phase, limit edged stir, 70-80 DEG C stir 0.5-0.8h make its complete emulsifying, be cooled to room temperature, namely obtain described external preparation.
Described step 4) in speed of agitator be 2000rmin
-1.
Embodiment 4
Treat a preparation method for the external preparation of closed injury, it comprises the following steps:
1) take nine kinds of medical materials such as Rhizoma Coptidis 12 parts, Radix Scutellariae 8 parts, Cortex Phellodendri 7 parts, Radix Et Rhizoma Rhei 13 parts, Pollen Typhae 11 parts, Radix Notoginseng 4 parts, Herba Lycopodii 12 parts, Herba speranskiae tuberculatae 12 parts, Calamina 18 parts by weight, pulverize grinding, cross 100 mesh sieves, obtain fine medicinal material powder, for subsequent use;
2) take after stearic acid 63 parts, Oleum Ricini 122 parts, liquid Paraffin 122 parts mix in container by weight, be heated to 70-80 DEG C, then add above-mentioned steps 1) in the fine medicinal material powder of gained, stir to obtain oil phase while hot;
3) take after triethanolamine 12 parts, glycerol 63 parts and distilled water 180 parts mix in another container by weight, be heated to 70-80 DEG C of miscible aqueous phase;
4) by above-mentioned steps 3) in aqueous phase slowly add in oil phase, limit edged stir, 70-80 DEG C stir 0.5-0.8h make its complete emulsifying, be cooled to room temperature, namely obtain described external preparation.
Described step 4) in speed of agitator be 2000rmin
-1.
The external preparation clinical observation test of test example treatment closed injury
1. clinical data
Have collected the service condition of the external preparation using the treatment closed injury obtained by the embodiment of the present invention 1,2,3,4 clinically, each embodiment case 50 example, amount to 200 examples, its case scenario is as follows:
2. relevant criterion
1. femur head necrosis is according to " practical orthopaedics and tranmstology " diagnosis.There is obvious hip trauma history; Long-term Hormone, excessive drinking history etc. is had without hip trauma history; Hip pain, based on adductor starting point place, pain can be persistence or intermittence, can be radiated to knee joint downwards; Difficulty in walking, in walking lamely, Progressive symmetric erythrokeratodermia increases the weight of; Hip joint function obstacle, based on inward turning, abduction, passive activity hip joint can have surrounding tissue cramp; All cases all passes through comprehensive health check-up, claps X sheet, CT and MRI checks and make a definite diagnosis.
2. acute soft tissue injury, comprises fascia, tendon, ligament and subcutaneous tissue, part muscle, joint capsule etc.; Local organization pain, swelling, tenderness, muscular spasm, dysfunction and skin burns etc.; X-ray checks without fracture.
3. Therapeutic Method
Adopt outside external preparation ointment of the present invention and put affected part on the skin, one time 5 grams, 3 times on the one; Weekly treatment 7 days 4 weeks is a course for the treatment of, and treatments period does not use the anxious perhaps blood stasis dispelling medicine of other anti-inflammatory analgetics.：
Observation index:
(1) severity extent assessment (point system)
1. pain: 3 points unbearably, 2 points, hypodynia 1 point can be born.
2. swelling: contrast > 1cm 3 points, < 1cm ~ > 0.5cm 2 points, < 0.5cm 1 point with footpath of strong side week.
3. tenderness: light tenderness or tenderness 3 points, tenderness are without tenderness 2 points, firmly tenderness 1 point.
4. muscular spasm: as plate-like elastic disappear 3 points, poor flexibility 2 points, slightly spasm elasticity can 1 points.
5. dysfunction: the limited > of joint motion 30 ° 3 points, < 20 ° 2 points, < 10 ° 1 point.
6. skin burns: obviously scorching hot 3 points, scorching hot 2 points of moderate, slight fever 1 point.
(2) state of an illness calibration: severe 13 ~ 18 points, moderate 7 ~ 12 points, slight 1 ~ 6 point.
(3) curative effect judgment criteria
1. fully recover: symptom and sign disappear completely, after treatment, total mark is not more than 2 points.
2. effective: symptom and sign are clearly better, after treatment, total mark reduces more than 2/3.
3. effective: symptom and sign are improved, after treatment, total mark reduces more than 1/3.
4. invalid: symptom and sign are not improved, after treatment, total mark reduces less than 1/3.
4. therapeutic outcome
Therapeutic outcome is as following table:
5. conclusion
According to above-mentioned Clinical observation, a kind of external preparation for the treatment of closed injury of the present invention has relaxing muscles and tendons to promote blood circulation, detumescence dissipating blood stasis, anti-inflammatory analgetic, and allaying tiredness impels circulation effect such as unobstructed.Pharmacological evaluation shows, external preparation ointment of the present invention is having obvious inhibitory action to inflammation swelling, promote the growth of beneficial cells, simultaneously, can continue to keep body in the reaction of increasing capillary permeability during inflammation swelling, in this case, the phagocyte of human body self can better gather the position of damage, to slough, the antibacterial entered engulfs, the edema of tissue can be eliminated gradually under good loop condition, the inflammatory cell infiltration of human body is lighter, the reproduction reparation of own cells can be carried out smoothly, after reparation, fibrous scar tissue is few, more after, function is good, therefore, the present invention has outstanding substantive distinguishing features and significant progress.
Claims (4)
1. treat an external preparation for closed injury, it is characterized in that: it comprises the raw material of following weight portion:
Rhizoma Coptidis 5-15 part Radix Scutellariae 5-15 part Cortex Phellodendri 5-15 part
Radix Et Rhizoma Rhei 5-15 part Pollen Typhae 5-15 part Radix Notoginseng 2-5 part
Herba Lycopodii 5-15 part Herba speranskiae tuberculatae 5-15 part Calamina 15-20 part
Stearic acid 60-65 part Oleum Ricini 120-124 part liquid Paraffin 120-124 part
Glycerol 60-65 part triethanolamine 8-12 part distilled water 100-200 part.
2. a kind of external preparation for the treatment of closed injury according to claim 1, is characterized in that: it comprises the raw material of following weight portion:
Rhizoma Coptidis 10 parts of Radix Scutellariaes 10 portions of Cortex Phellodendris 10 parts
Radix Et Rhizoma Rhei 10 parts of Pollen Typhaes 10 portions of Radix Notoginseng 3 parts
Herba Lycopodii 10 parts of Herba speranskiae tuberculataes 10 parts of Calaminas 17 parts
Stearic acid 62 parts of Oleum Ricini 124 parts of liquid Paraffin 124 parts
Glycerol 62 parts of triethanolamine 10 parts of distilled water 150 parts.
3. a preparation method for the external preparation for the treatment of closed injury as claimed in claim 1 or 2, is characterized in that: it comprises the following steps:
1) take Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, Pollen Typhae, Radix Notoginseng, Herba Lycopodii, Herba speranskiae tuberculatae, Calamina nine kinds of medical materials by described parts by weight of raw materials proportioning, pulverize grinding, cross 100 mesh sieves, obtain fine medicinal material powder for subsequent use;
2) take after stearic acid, Oleum Ricini, liquid Paraffin mix in container by described parts by weight of raw materials proportioning, be heated to 70-80 DEG C, then add above-mentioned steps 1) in the fine medicinal material powder of gained, stir to obtain oil phase while hot;
3) take after triethanolamine, glycerol and distilled water mix in another container by described parts by weight of raw materials proportioning, be heated to 70-80 DEG C of miscible aqueous phase;
4) by above-mentioned steps 3) in aqueous phase slowly add in oil phase, limit edged stir, 70-80 DEG C stir 0.5-0.8h make its complete emulsifying, be cooled to room temperature, namely obtain described external preparation.
4. a kind of preparation method for the treatment of the external preparation of closed injury according to claim 3, is characterized in that: in described step 4), speed of agitator is 2000 rmin
-1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105125794A (en) * | 2015-09-06 | 2015-12-09 | 青岛大学 | Pure traditional Chinese medicinal cream for treating closed injury caused by acute physical exercise and preparation method of pure traditional Chinese medicinal cream |
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| CN1173356A (en) * | 1997-07-02 | 1998-02-18 | 陈运祥 | Method for prepn. of Chinese medicinal external application ointment for diminishing inflammation, stopping pain and setting fracture |
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| CN1173356A (en) * | 1997-07-02 | 1998-02-18 | 陈运祥 | Method for prepn. of Chinese medicinal external application ointment for diminishing inflammation, stopping pain and setting fracture |
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| CN105125794A (en) * | 2015-09-06 | 2015-12-09 | 青岛大学 | Pure traditional Chinese medicinal cream for treating closed injury caused by acute physical exercise and preparation method of pure traditional Chinese medicinal cream |
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