CN106511510A - Medicine composition used for treating wind-cold-damp arthralgia and muscle and bone strain - Google Patents
Medicine composition used for treating wind-cold-damp arthralgia and muscle and bone strain Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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Abstract
The invention discloses a medicine composition used for treating wind-cold-damp arthralgia and muscle and bone strain, and belongs to the technical field of medicines. The composition is prepared from the following components in parts by weight: 24-28 parts of rhizoma seu radix notopterygii, 24-28 parts of radix angelicae pubescentis, 8-12 parts of szechuan lovage rhizome, 3-7 parts of myrrh, 3-7 parts of frankincense, 9-11 parts of radix achyranthis bidentatae and 15-18 parts of radix aconiti preparata. The components are relatively simple and are all common Chinese herbal medicines, so that the cost is relatively low; an external preparation is preferentially adopted, so that safety and reliability are achieved; a proper ratio is adopted and the components cooperate mutually, so that the effects of removing wind-damp and activating blood to stop pain can be achieved; and the composition is especially suitable for the wind-cold-damp arthralgia, the muscle and bone joint strain, neck-shoulder-back pain, waist-leg pain, inconvenient joint flexion and extension, and the like, and is definite in curative effect, small in toxic and side effects and difficult in relapse.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, more particularly to a kind of drug regimen for treating the strain of anemofrigid-damp arthralgia muscles and bones
Thing.
Background technology
As neck shoulder back pain occur in the deterioration and the change of life and work custom of environment, increasing people, lumbago and skelalgia is closed
The symptoms such as section joint stuffiness, and these symptoms are presented the trend of increasingly rejuvenation, have had a strong impact on the quality of life of people
And work.
Above-mentioned symptom, from the angle of the traditional Chinese medical science, the whole-body muscle joint wind-engaging of people, cold, summer-heat, wet, dry, fiery " six climate exopathogens " are invaded
Attack, or wound, chronic strain, transdermal causes a disease to the marrow and forms " six is malicious ", that is, " bone is malicious "." bone poison " long-term existence is in bone and bone
" place poison " is formed on film.Place poison causes bone and periarticular is soft knits hyperemia, edema, adhesion, contracture repeatedly, so as to cause locally
Disturbance of blood circulation, producing a large amount of acidic materials stimulates blood vessel, damages muscular tissue, shows as muscle muscles and bones joint aches, fiber crops
Wood, swelling, or even red and swollen deformation, severe one can cause the destruction of joint sclerotin, joint deformity can't take care of oneself.
In simple terms, above-mentioned symptom, its reason are divided into causing because of self reasons such as strains and because wind-cold damp pathogen etc. is outside
Two big class that reason causes.
Wherein, because the muscles and bones arthralgia that causes of self reason such as strain, including lumbar muscle strain, cervical spondylosiss, scapulohumeral periarthritis,
Muscles and bones joint aches, the pain such as neck that prolapse of lumbar intervertebral disc etc. causes, shoulder, waist, lower limb；Because the external causes such as wind-cold damp pathogen cause muscle
Bone joint pain, including the reason such as rheumatism, rheumatoid cause muscles and bones joint aches, pain numbness, joint stuffiness etc..
At present, for strain or the muscles and bones arthralgia that causes of wind-cold damp pathogen, doctor trained in Western medicine often can only symptomatic treatment, it is temporarily slow
Solution symptom, cures the symptoms, not the disease, or even to control target effect also poor.And the traditional Chinese medical science in this respect with the obvious advantage, have at present it is many
The Chinese medicine preparation of Jing reports, its curative effect are substantially better than Western medicine.
But, present Chinese medicine preparation, often exist complicated component, safety is relatively low, need rare Chinese medicine cost compared with
The shortcomings of high, curative effect is remained to be further improved.Such as, Application No. 201110399703.2, entitled " one kind treats wind
Chinese medicine preparation disclosed in the Chinese patent of damp disease or rheumatoid medicament ", employs the 20 taste Chinese crude drug such as Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss,
Its complicated component, the interaction between component are also very complicated, and its safety has very big uncertainty, and curative effect also needs
Improve.
The content of the invention
The present invention goal of the invention be：A kind of new drug regimen for treating the strain of anemofrigid-damp arthralgia muscles and bones is provided
Thing, to solve the above problems.
The technical solution used in the present invention is such：A kind of drug regimen for treating the strain of anemofrigid-damp arthralgia muscles and bones
Thing, is made up of following components in parts by weight：
Rhizoma Et Radix Notopterygii：24-28 parts, Radix Angelicae Pubescentiss：24-28 parts, Rhizoma Chuanxiong：8-12 parts, Myrrha：3-7 parts, Olibanum：3-7 parts, Radix Achyranthis Bidentatae：9-11 part g,
Radix Aconiti Preparata：15-18 parts.
The present inventor is drawn by many experiments：Between said components, using suitable ratio, mutually cooperate with,
Anemofrigid-damp arthralgia, muscles and bones articular strain, symptoms include neck shoulder back pain, lumbago and skelalgia, joint can be particularly suited for wind-damp dispelling, promoting blood circulation and stopping pain
Joint stuffiness etc., its determined curative effect, toxic and side effects are little, are difficult recurrence.
Wherein, Rhizoma Et Radix Notopterygii, is samphire Rhizoma Et Radix Notopterygii（Notopterygium incisum）Rhizome, warm in nature, dispelling cold and dampness,
For affection of exogenous wind-cold, have a headache lossless, anemofrigid-damp arthralgia, upper limb rheumatalgia etc., likewise, treating rheumatism iff using Rhizoma Et Radix Notopterygii
Class disease, its curative effect are very poor；
Radix Angelicae Pubescentiss, are samphire Angelica pubescens Angelica pubescens Maxim.f. biserrata Shan et
The dry root of Yuan, acrid in the mouth, hardship, slightly warm in nature return kidney, bladder warp, expelling wind and removing dampness, arthralgia aggravated by cold pain relieving for anemofrigid-damp arthralgia, will wash pain
Bitterly, few the moon volt wind headache, wind and cold hold wet headache under the arm；Likewise, treating rheumatism iff using Rhizoma Et Radix Notopterygii, its curative effect is very
Difference；
Rhizoma Chuanxiong, is samphire Rhizoma Chuanxiong（Ligusticum chuanxiong Hort.）Rhizome, be usually used in blood-activating and qi-promoting,
Wind-expelling pain-stopping, Rhizoma Chuanxiong pungent-warm perfume (or spice) are dry, walk and do not keep, can go it is scattered, it is up up to mountain peak push up；Enter blood system again, it is descending up to the sea of blood, it is living
Blood and dissolving stasis effect is extensive, the various diseases of suitable stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness are favourable, can control head wind headache, rheumatic arthralgia etc.
Disease；But, rheumatism is treated iff using Rhizoma Chuanxiong, its curative effect is very poor；And, present inventor will be above-mentioned
Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss carry out compatibility, and the clinical effectiveness of its treatment rheumatism is also very poor；
Myrrha is olive subject plant Herba Violae tree Commiphora myrrha Engl. or breathes out Herba Violae tree Commiphora molmol
Engl. dry resin；Acrid in the mouth, hardship, it is mild-natured；GUIXIN, liver, spleen channel；Scattered stasis pain, detumescence and promoting granulation；It is usually used in obstruction of qi in the chest and cardialgia, stomach
Gastral cavity pain, dysmenorrhea amenorrhea. the treatment of the disease such as postpartum stagnation, abdominal mass stomachache, rheumatic arthralgia, traumatic injury, carbuncle swells sore；
Olibanum, is olive subject plant Boswellia carterii Boswellia carterii Birdw. and congener Boswellia
The resin that bhaurdajiana Birdw. barks ooze out；Acrid in the mouth, hardship, temperature；GUIXIN, liver, spleen channel；Blood-activating and qi-promoting pain relieving, detumescence life
Flesh；It is usually used in obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation, lump in the abdomen stomachache, rheumatic arthralgia, muscle arteries and veins contraction, traumatic injury
Damage, carbuncle swells sore；
Radix Achyranthis Bidentatae, is amaranthaceous plant Radix Achyranthis Bidentatae（Achyranthes bidentata Blume）Dry root, property is bitter, sweet, sour, puts down；Return
Liver and kidney channel；Eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards；It is usually used in amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscle
Bone is powerless, stranguria, edema, headache, dizziness, toothache, day skin ulcer, spit blood, epistaxis etc.；
Radix Aconiti Preparata, is ranunculaceae plant Radix Aconiti（Aconitum carmichaelii）The processed product of dry root, acrid in the mouth, hardship, property
Heat；GUIXIN, liver,kidney,spleen Jing, expelling wind and removing dampness, antalgic are usually used in for anemofrigid-damp arthralgia, and joint cold type of pain, colic of cold type are had a pain and fiber crops
Liquor-saturated pain relieving.
As preferred technical scheme, it is made up of following components in parts by weight：
Rhizoma Et Radix Notopterygii：25-27 parts, Radix Angelicae Pubescentiss：25-27 parts, Rhizoma Chuanxiong：10-12 parts, Myrrha：3-5 parts, Olibanum：3-5 parts, Radix Achyranthis Bidentatae：9-10 parts
G, Radix Aconiti Preparata：15-16 parts.Which is better.
As further preferred technical scheme, it is made up of following components in parts by weight：
Rhizoma Et Radix Notopterygii：26 parts, Radix Angelicae Pubescentiss：26 parts, Rhizoma Chuanxiong：12 parts, Myrrha：3 parts, Olibanum：3 parts, Radix Achyranthis Bidentatae：10 parts of g, Radix Aconiti Preparata： 16
Part.
The present invention also provides pharmaceutical preparation made by above-mentioned composition.
The preparation is preferably powder, or other external preparation.
The preparation method of above-mentioned powder is to weigh in the ratio, crushes, sieves, and mixes, obtains final product, and gained preparation is yellowish-brown
The powder of color to light brown；Gas is fragrant.
As preferred technical scheme：120 mesh sieves are crossed after crushing.
The preparation method of the present invention is simple, low cost.
In sum, as a result of above-mentioned technical proposal, the invention has the beneficial effects as follows：The present invention is only by seven taste Chinese medicines
Composition, composition are relatively easy, and component is common Chinese crude drug, and cost is relatively low, and preferably adopts external preparation, safely may be used
Lean on；100% is reached for treating the strain of each analgesic bone and drawing effective percentage, cure rate is up to 89%；Treat the effective of various anemofrigid-damp arthralgia
Rate reaches 100%, cure rate up to 82%, instant effect, determined curative effect, and relapse rate is less than 10%.
Specific embodiment
The present invention is described in detail below.
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein is not used to only to explain the present invention
Limit the present invention.
Embodiment 1：
A kind of pharmaceutical composition for treating the strain of anemofrigid-damp arthralgia muscles and bones, is made up of following components in parts by weight：
Rhizoma Et Radix Notopterygii：28 parts, Radix Angelicae Pubescentiss：25 parts, Rhizoma Chuanxiong：8 parts, Myrrha：3 parts, Olibanum：7 parts, Radix Achyranthis Bidentatae：9 parts of g, Radix Aconiti Preparata：15 parts；
Preparation method is：Preparation method is：Weigh in the ratio, crush, cross 120 mesh sieves, mix, obtain final product.
Embodiment 2
Rhizoma Et Radix Notopterygii：24 parts, Radix Angelicae Pubescentiss：24 parts, Rhizoma Chuanxiong：12 parts, Myrrha：7 parts, Olibanum：3 parts, Radix Achyranthis Bidentatae：11 parts of g, Radix Aconiti Preparata： 18
Part；
Preparation method is：Preparation method is：Weigh in the ratio, crush, cross 120 mesh sieves, mix, obtain final product.
Embodiment 3
A kind of pharmaceutical composition for treating the strain of anemofrigid-damp arthralgia muscles and bones, is made up of following components in parts by weight
Rhizoma Et Radix Notopterygii：26 parts, Radix Angelicae Pubescentiss：26 parts, Rhizoma Chuanxiong：12 parts, Myrrha：3 parts, Olibanum：3 parts, Radix Achyranthis Bidentatae：10 parts of g, Radix Aconiti Preparata： 16
Part；
Preparation method is：Weigh in the ratio, crush, cross 120 mesh sieves, mix, obtain final product.
Embodiment 4
The clinical trial for the treatment of muscles and bones strain
4.1 case selection
Selection is diagnosed as the patient each 40 of the strain of mobility's knee joint, lumbar muscle strain, cervical spondylosiss, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc
Name, its symptom is neck shoulder back pain, lumbago and skelalgia, knee pain, joint joint stuffiness, wherein, male 120, women 80, the course of disease is
60 of half a year to 1 year, 60 of 1 year to 3 years, 80 of more than 3 years；
4.2 Therapeutic Method
According to affected part size, the powder 5-10g obtained by Example 3, first with wine, medicated powder adjustment is pasted by rear warm water
Shape, spreads on affected part, daily using twice, sooner or later respectively once, according to the serious conditions of the state of an illness, using 10-30 days；
4.3 the standard of curative effect evaluation
Evaluated according to following standards：
Cure：Muscles and bones symptoms of joint pain is wholly absent, and joint is bent and stretched normally, be discontinued 30 days after without it is any repeatedly；
It is effective：Muscles and bones symptoms of joint pain disappears substantially, and joint is bent and stretched normal；
Effectively：Symptoms of joint pain mitigates；
It is invalid：Compared with pre-treatment, without any change.
4.4 therapeutic outcome
According to above-mentioned standard, 200 tested patients, cure 178, effective 6, effective 16, effective percentage is cured up to 100%
Rate is up to 89%, and pays a return visit after half a year, in 178 of healing, only 6 recurrences.
4.5 model case
King so-and-so, man, 45 years old, Professional Basketball Athlete was played basketball up to more than 30 years, the gonalgia occurs within nearly 10 years, stiff,
Joint stuffiness, using various integrative therapies, including the physiotherapy such as acupuncture, massage massage, recurrence recurrence always, difficulty in walking,
After being treated 20 days using 4.2 Therapeutic Method, the gonalgia substantially mitigates, and after 10 days, pain is wholly absent continual cure, closes
Section bends and stretches normal, and daily walking is completely normal, and can carry out appropriate basketball movement, and latter year of being discontinued pays a return visit, without any recurrence.
Chen, female, 56 years old, long campaigns were bent over one's desk working, shoulder long pain, and shoulder mobility is limited, shoulder joint week
Confined pressure pain, checks that by shoulder joint MRI being diagnosed as scapulohumeral periarthritis be up to 10 years, in addition waist long pain, and left lower extremity is radiated
Property pain, typical prolapse of lumbar intervertebral disc taken a large amount of Chinese medicines and Western medicine, and using modes such as massages, can only be temporary
When mitigate symptom, recur after drug withdrawal；Treated after two months using 4.2 Therapeutic Method, shoulder pain tenderness is wholly absent, shoulder
Joint motion recovers normal completely, and pain in the lumbar region is wholly absent, and left lower extremity radiated pain is wholly absent, and latter year of being discontinued pays a return visit,
Without any recurrence.
Embodiment 5
For the clinical trial of anemofrigid-damp arthralgia treatment
5.1 case selection standard：
Western medicine diagnostic criteria：The standard that reference " American Rheumatism Association " is formulated, i.e.,：According to medical history, physical diagnosiss and radiology
Inspection result：Joint congestion and swelling pain, 3 be provided simultaneously with following 6 conditions make a definite diagnosis selected, and 1. radiology shows bone
It is superfluous to be formed；2. it is stiff from morning to be less than 30 minutes；3. there is bone sound during joint motion；4. knee joint bone increase；5. there is bone tenderness；⑥
Heat up without obvious synovial membrane.
Tcm diagnosis standard：Symptoms include joint congestion and swelling pain, especially knee joint, articulations digitorum manus, or even joint deformity, active receiving
Limit.
5.2 case scenario
By the rheumatic and rheumatoid patient of above-mentioned standard selection all ages and classes, different sexes, the different state of an illness, totally 100 conduct experiments are right
As, wherein, 31-40 year 25,41-50 year 50,51-65 year 25；Male 50, women 50；Course of disease 2-3 25,
Course of disease 3-5 25, course of disease 5-8 25, the course of disease more than 8 years 25；
5.3 Therapeutic Method
According to affected part size, the powder 5-10g obtained by Example 3, first with wine, medicated powder adjustment is pasted by rear warm water
Shape, spreads on affected part, daily using twice, sooner or later respectively once, according to the serious conditions of the state of an illness, using 30-60 days；
5.4 the standard of curative effect evaluation
Evaluated according to following standards：
Cure：Symptoms of joint pain is wholly absent, and without morning stiffness phenomenon, physico-chemical examination is completely normal；
It is effective：Symptoms of joint pain disappears substantially, and the morning stiffness time shortens or without morning stiffness, and physico-chemical examination is normal；
Effectively：Symptoms of joint pain mitigates, and physico-chemical examination makes moderate progress；
It is invalid：Compared with pre-treatment, without mitigation, physico-chemical examination is without change for arthralgia.
5.5 therapeutic outcome
Above-mentioned 100 cases, cure：82；It is effective：8；Effectively:10；It is invalid：0, effective percentage is 100%, and cure rate is
82.0%, illustrate that the medicine of the present invention is notable for rheumatism, rheumatoid therapeutic effect；And it is significantly bad anti-without feedback
Should；
In addition, follow-up after treatment half a year, in 82 of healing, only 2 recurrences, relapse rate are very low.
5.6 model case：
Liu so-and-so, female, 50 years old, rheumatoid medical history 5 years, redness and swelling of joints, arthralgia；
Using 5.3 method, using 30 days, symptom was wholly absent, and arthralgia is wholly absent, and joint function recovery is normal, main
Want physico-chemical examination index normal；
It is single so-and-so, man, 69 years old, rheumatism medical history more than 10 years, redness and swelling of joints, arthralgia simultaneously deformed, recurrent exerbation, adopted
5.3 method, using 60 days after, symptom is wholly absent, and joint function recovery is normal, and main physico-chemical examination index is normal.
Claims (7)
1. it is a kind of for treat anemofrigid-damp arthralgia muscles and bones strain pharmaceutical composition, it is characterised in that by following components in parts by weight
Composition：
Rhizoma Et Radix Notopterygii：24-28 parts, Radix Angelicae Pubescentiss：24-28 parts, Rhizoma Chuanxiong：8-12 parts, Myrrha：3-7 parts, Olibanum：3-7 parts, Radix Achyranthis Bidentatae：9-11 part g,
Radix Aconiti Preparata：15-18 parts.
2. it is according to claim 1 for treat anemofrigid-damp arthralgia muscles and bones strain pharmaceutical composition, it is characterised in that by under
State the component composition of weight portion：
Rhizoma Et Radix Notopterygii：25-27 parts, Radix Angelicae Pubescentiss：25-27 parts, Rhizoma Chuanxiong：10-12 parts, Myrrha：3-5 parts, Olibanum：3-5 parts, Radix Achyranthis Bidentatae：9-10 parts
G, Radix Aconiti Preparata：15-16 parts.
3. it is according to claim 2 for treat anemofrigid-damp arthralgia muscles and bones strain pharmaceutical composition, it is characterised in that by under
State the component composition of weight portion：
Rhizoma Et Radix Notopterygii：26 parts, Radix Angelicae Pubescentiss：26 parts, Rhizoma Chuanxiong：12 parts, Myrrha：3 parts, Olibanum：3 parts, Radix Achyranthis Bidentatae：10 parts of g, Radix Aconiti Preparata： 16
Part.
4. pharmaceutical preparation made by the compositionss of claim 1-3 any one is adopted.
5. pharmaceutical preparation according to claim 4, it is characterised in that：The preparation is powder.
6. the preparation method of powder described in claim 5, it is characterised in that：Weigh in the ratio, crush, sieve, mix, i.e.,
.
7. preparation method according to claim 6, it is characterised in that：120 mesh sieves are crossed after crushing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611189270.7A CN106511510A (en) | 2016-12-21 | 2016-12-21 | Medicine composition used for treating wind-cold-damp arthralgia and muscle and bone strain |
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| CN201611189270.7A CN106511510A (en) | 2016-12-21 | 2016-12-21 | Medicine composition used for treating wind-cold-damp arthralgia and muscle and bone strain |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110327403A (en) * | 2019-08-23 | 2019-10-15 | 李森 | A kind of Chinese medicine fuming-lotion that treating rheumatic arthralgia and its application method |
| CN110917316A (en) * | 2019-12-30 | 2020-03-27 | 赵健 | A plaster for treating rheumatism and rheumatoid diseases and preparation method of plaster patch thereof |
| CN113117042A (en) * | 2021-05-14 | 2021-07-16 | 李晓晓 | Chinese medicinal composition for treating arthralgia due to wind-cold-dampness-heat pathogen, strain and traumatic injury |
| CN114404480A (en) * | 2022-01-27 | 2022-04-29 | 山西同福仁康生物科技有限公司 | Muscle and bone joint plaster and preparation method thereof |
Citations (1)
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| CN105727118A (en) * | 2016-02-26 | 2016-07-06 | 卜现国 | Medicinal liquor for treating wind-cold-dampness arthralgia and preparation method for medicinal liquor |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105727118A (en) * | 2016-02-26 | 2016-07-06 | 卜现国 | Medicinal liquor for treating wind-cold-dampness arthralgia and preparation method for medicinal liquor |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110327403A (en) * | 2019-08-23 | 2019-10-15 | 李森 | A kind of Chinese medicine fuming-lotion that treating rheumatic arthralgia and its application method |
| CN110917316A (en) * | 2019-12-30 | 2020-03-27 | 赵健 | A plaster for treating rheumatism and rheumatoid diseases and preparation method of plaster patch thereof |
| CN113117042A (en) * | 2021-05-14 | 2021-07-16 | 李晓晓 | Chinese medicinal composition for treating arthralgia due to wind-cold-dampness-heat pathogen, strain and traumatic injury |
| CN114404480A (en) * | 2022-01-27 | 2022-04-29 | 山西同福仁康生物科技有限公司 | Muscle and bone joint plaster and preparation method thereof |
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Application publication date: 20170322 |