CN102552823A - Medicine for treating osteoarthritis and preparation method thereof - Google Patents
Medicine for treating osteoarthritis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of Chinese patent medicines, and in particular relates to a medicine for treating osteoarthritis and a preparation method of the medicine. The patent solves the problems of toxic and side effects, big harm on bodies, poor curative effect, temporary medical relief and the like with medicine for treating osteoarthritis in prior art. The medicine in the invention is prepared from vinegar-processed frankincense, vinegar-processed myrrh, white peony root, pseudoginseng, Lamiophlomis rotata, safflower, turmeric, dragon's blood, notopterygium root, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae, Achyranthes bidentata, cassia twig and processed Semen Strychni. The preparation method comprises the steps of: pulverizing the five raw medicinal materials of the vinegar-processed frankincense, vinegar-processed myrrh, pseudoginseng, the dragon's blood and the processed Semen Strychni into fine powder, then preparing the other nine raw medicinal materials into thick paste, and finally uniformly mixing the fine powder with the thick paste; and drying and pulverizing into powder, then adding 5%-10% of starch to the powder, uniformly mixing and sterilizing to obtain a capsule preparation. The medicine has the advantages of good curative effect and low side effect, and can treat both principal and secondary aspects of diseases and the like.
Description
Technical field
The invention belongs to the Chinese Traditional Medicines technical field, be specifically related to a kind of medicine of treating osteoarthritis and preparation method thereof.
Background technology
Osteoarthritis (osteoarthritis; OA) be a kind of common arthritis, be commonly called as " hyperosteogeny ", claim osteoarthritis, osteoarthritis, degenerative osteoarthritis, hypertrophiarthritis, senile arthritis and proliferative arthritis etc. again; Good sending out in big, the movable many joints of heavy burden; As: knee joint, hip joint, spinal column (like cervical vertebra and lumbar vertebra) ankle etc., bring insufferable misery to patient, and knee joint osseous arthritis is more common.Present treatment osteoarthritis mainly is three kinds in operation, Western medicine and a Chinese medicine, and operative treatment has a big risk and is difficult to treatment; Western medicine mainly is the alleviating pain symptom also, but side effect is a lot, and is very big to the injury of health; Life-time service has the danger of digestive tract hemorrhage, and lesions of liver and kidney also takes place easily.Chinese traditional treatment takes effect slowly, but treating both the principal and the secondary aspects of a disease at the same time, the effect that often can play.
Summary of the invention
The poisonous side effect of medicine that the present invention is primarily aimed at present treatment osteoarthritis is many, and is big to actual bodily harm, unsatisfactory curative effect; It is not enough to cure the symptoms, not the disease etc.; And a kind of determined curative effect is provided, and comprehensively regulating, treatment back is difficult for recurrence and medicine cheap, the treatment osteoarthritis that has no side effect.
The present invention also provides the method for preparing of this medicine.
The present invention for realizing the technical scheme that above-mentioned purpose is taked is:
A kind of medicine of treating osteoarthritis is to be crude drug with following parts of medicines by weight:
Olibanum (processed with vinegar) 3～5, Myrrha (processed with vinegar) 3～5, the Radix Paeoniae Alba 6～15, Radix Notoginseng 3～9, Radix Lamiophlomidis Rotatae 2～6, Flos Carthami 3～10, Rhizoma Curcumae Longae 3～10, Sanguis Draxonis 1～3, Rhizoma Et Radix Notopterygii 3～10, Radix Angelicae Pubescentis 3～10, Radix Gentianae Macrophyllae 3～10, Radix Achyranthis Bidentatae 5～12, Ramulus Cinnamomi 3～10, Semen Strychni (processed) 3～6;
Wherein said Olibanum (processed with vinegar) and Myrrha (processed with vinegar) be with Olibanum with do not have the medicated vinegar parch to become, Semen Strychni (processed) is to process with Semen Strychni according to traditional method.
The method for preparing of medicine of the present invention is following:
Earlier Olibanum (processed with vinegar), Myrrha (processed with vinegar), Radix Notoginseng, Sanguis Draxonis and Semen Strychni (processed) five tastes crude drug are ground into 80～120 purpose fine powders, again all the other nine flavor crude drug being used mass fractions is 60～80% alcohol reflux 2～4 times, adds the ethanol of 6～10 times of amounts at every turn; Extracted 2～4 hours; Merge extractive liquid, filters, and collects medicinal residues; Reclaim ethanol, will cross then filterable extracting solution be condensed into temperature when being 55～65 ℃ relative density be 1.35～1.38 thick paste I; Get the medicinal residues decocte with water 2～4 times of collection again, add the water of 6～10 times of amounts at every turn, decocted 1～3 hour; Merge extractive liquid,, filtration, with extracting solution be condensed into temperature when being 75～85 ℃ relative density be 1.35～1.38 thick paste II, at last with fine powder, thick paste I and thick paste II mix homogeneously; Dry; Be ground into 80～120 purpose powder, in powder, add the starch mix homogeneously of powder weight 5～10% again, process capsule preparations.
The present invention has stressed group prescription frankincense qi and blood circulation, and pain, chasing toxicity; myrrh with blood and pain, swelling and tissue regeneration effect; peony with nourishing the liver, reduce the pain, grabbing Yin Khan received the role; three seven with the expansion of blood vessels, lowering blood pressure, the role of microcirculation; Duyiwei with stasis, swelling and pain of the role; safflower with blood circulation, stasis analgesic effect; turmeric with expelling gas line, pass through the pain of effect; Dragon's Blood with blood stasis, bleeding and pain, sore myogenic role; Notopterygium has antipyretic, anti-inflammatory effect; independent living with Qufeng wins wet, cold analgesic effect; Gentiana has eradicates rheumatism, Shu veins, Qingxudong action of heat; Achyranthes with blood circulation, fire (blood) down, diuretic Tonglin role; Guizhi with sweating Jie Ji, warm tongmai, yang of gas, cold analgesic effect; horse vomica has Tongluozhitong, reducing swelling effect;
The compatibility relationship of prescription of the present invention is: with the Radix Achyranthis Bidentatae monarch drug, and invigorating the liver and kidney, bone and muscle strengthening, removing blood stasis collateral dredging; With Semen Strychni, Olibanum, Myrrha, Rhizoma Curcumae Longae, Radix Notoginseng, Flos Carthami, sanguis draconis scorpion, Radix Lamiophlomidis Rotatae is ministerial drug, mass dissipating and swelling eliminating, removing obstruction in the collateral to relieve pain, promoting flow of QI and blood, detumescence and promoting granulation; With Ramulus Cinnamomi, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae is adjuvant altogether, easing the affected liver to relieve pain, wind-damp dispelling, stopping numbness pain, reducing the asthenic fever.
For further showing the therapeutic effect of medicine of the present invention, done following clinical verification:
The patient chooses
91 osteoarthritis patients of hospital outpatient picked at random, be divided into two groups by the table of random number method, matched group 45 examples, 46 examples are organized in treatment.
Diagnostic criteria
Knee joint osseous arthritis diagnostic criteria: the gonalgia repeatedly in 1. nearly 1 month; 2. X-ray film (stand or bear a heavy burden) shows that the joint space narrows down, subchondral bone sclerosis and/or cystis degeneration, joint margins hyperosteogeny form; 3. joint fluid (at least 2 times) is limpid, sticky, < 2000/>ml of WBC; 4. morning deadlock≤30min; Bony crepitus (sense) is arranged when 5. movable.
Lonizing radiation knee osteoarthritis grade scale: being divided into according to Kellgren and Lawrence method is 5 grades, 1. 0 grade: for normally; 2. I level: the joint space is suspicious to narrow down, and has hyperosteogeny; 3. II level: tangible hyperosteogeny is arranged, and the joint space is suspicious to narrow down; 4. III level: the moderate hyperosteogeny, the joint space narrows down clearer and more definite, has hardening to change; 5. IV level: a large amount of hyperosteogenys, the joint space obviously narrows down, serious hardening pathological changes and obvious deformity.
The syndrome diagnostic criteria:
Main symptom: arthralgia, pain character are twinge or ache that sore spot is fixed, the soft soreness of waist of knee joint.
Inferior card: movable unfavorable, operate forced, joint deformity, dim complexion, dark tongue quality or the ecchymosis petechia is arranged, thin fur or in vain thin, deep pulse or carefully puckery.
Include standard in: 1. meet the patient that knee joint osseous arthritis diagnostic criteria and Syndrome in TCM marquis are diagnosed as caused by liver and kidney deficiency, muscle arteries and veins stasis type; 2. the patient of age between 40-75 years old; 3. do not use similar medicine or treatment means therapist in nearly one month; 4. sign Informed Consent Form, be ready to cooperate this researcher.
Exclusion standard: 1. do not meet above-mentioned standard person; 2. the age is lower than 40 years old or surpasses 75 years old person; 3. be in trimester of pregnancy, age of sucking, or prepare the women of gestation; 4. merge primary diseases such as serious hepatic and kidney function obstacle, activeness digestive tract ulcer, diabetes severe complication, cardiovascular and cerebrovascular disease, blood system, and spiritedness medical history person; 5. intercurrent diseases such as psoriasis, syphilis property neuropathy, ochronosis, metabolic osteopathy, acute injury have influence on the joint person; 4. this medicine composition there is allergies person; 5. the state of an illness is critical, is difficult to definite estimator is made in new drug effectiveness, safety; 6. take the other treatment medicine for treating arthritis for a long time, be in drug influence in the phase, fail the eluting person.
Rejecting standard: one of following situation is arranged for rejecting case, 1. occur other serious concurrent diseases or state of an illness rapid deterioration in the experimentation need take emergent management measure person; 2. due to illness feelings need not accomplished therapist; 3. do not accomplish the scale person of filling in because of a variety of causes.
Therapeutic Method
The treatment group: medicine of the present invention, every day three times, each four, oral after the meal.
Matched group: according to 2007 editions " arthritis diagnosis and treatment guide " Therapeutic Principle, select ibuprofen modified release capsule (Sino-America Tianjin Shike Pharmaceutical Co., Ltd., the accurate word H10900089 of traditional Chinese medicines) treatment, 0.3g, 1 time 1, sooner or later oral.
2 weeks were 1 course of treatment, in 2 post-evaluations course of treatment of medication curative effect, and did evaluation in drug withdrawal 1 Zhou Houzai.Advise the patient to reduce irrational motion during the treatment, an amount of movable, avoid faulty posture, avoid long-time race, jumping, crouching, reduce or avoid stair climbing.
All experimenters all must not merge the medicine and the medicine that possibly influence clinical efficacy and untoward reaction evaluation that uses any other treatment degeneration knee osteoarthritis at duration of test.
Observation index
Safety observation: 1. health check-up project; 2. blood, urine, stool routine chemical examination; 3. the heart, liver, kidney function test;
The curative effect of disease evaluation criterion:
1, the observation of clinical syndrome: comprise the gonalgia, send out deadlock, symptoms such as dysfunction;
1. pain or aching and tired discomfort during night's rest: no pain or uncomfortable 0 minute; Idol has pain or aching and tired uncomfortable 1 minute during night's rest; Night's rest had pain 2 minutes constantly; Frequent pain is 3 minutes during night's rest;
2. played stiff sense morning or get up the back pain increase the weight of: played pain and stiff sense no morning 0 minute; Played stiff sense morning, movable slightly back disappeared 1 fen; Played stiff pain morning, alleviated after the activity slightly 2 fens; Pain is stiff obviously, can not alleviate after the activity 3 fens;
The gonalgia or discomfort when 3. walking: do not have pain or discomfort 0 minute during walking; Long distance walking (＞1km) patella had pain or sense of discomfort 1 minute; Short walk (＜1km) patella has pain or uncomfortable 2 minutes; Once the knee joint pain of walking, walking back pain increased the weight of 3 fens;
4. pain or discomfort when seat is stood: no pain or uncomfortable 0 minute; Pain or discomfort 1 minute is arranged slightly; Pain or obviously uncomfortable can not stood 2 fens but do not want help voluntarily; Pain is obvious, wants help to stand 3 fens;
5. maximum travel distance (can walk): normal 0 minute with pain;＞1km, but limited 1 minute; 500m-1km 2 minutes;＜500m 3 minutes;
6. daily Ambulatory Activity: do not have difficulty 0 minute; Idol had difficulty in walking 1 minute; The time difficulty in walking is arranged 2 minutes; Can not walk 3 fens;
7. squat down or the flexing knee joint: can squat down or flexing knee joint 1 minute; Squat down or flexing knee joint difficulty 2 minutes; Can not squat down or flexing knee joint 3 minutes;
8. walk in that level road not is up: can walk 1 fen in that level road not is up; Walked difficulty 2 minutes in that level road not is up; Can not walk 3 fens.
2, sign and function observation: comprise the test of tenderness in knee and passive flexion and extension, floating patella test etc.
1. kneed mobility: spend 0 fen greater than 120; 90-120 degree 1 minute; 60-90 degree 2 minutes; Spend 3 fens less than 60;
2. arthroncus degree: knee joint did not have swelling 0 minute; The knee joint mild swelling, high-visible 1 minute of joint bone mark; The swelling of knee joint moderate, not obvious 2 minutes of joint bone mark; The swelling of knee joint severe, ossa articularia property marks obliterated 3 minutes;
3. knee joint peripheral tenderness: knee joint peripheral did not have tenderness 0 minute; The local tenderness of knee joint peripheral 1 minute; The extensive tenderness of knee joint peripheral 2 minutes;
4. knee joint endoprosthesis strand cable: no knee joint strand cable 0 minute; Accidental knee joint strand cable 1 minute; The knee joint that takes place frequently strand cable 2 minutes;
5. knee joint snap sound: knee joint did not have snap 0 minute; The knee joint idol had snap 1 minute; Take place frequently snap 2 minutes of knee joint;
6. beat soft lower limb: do not have and beat soft leg phenomenon 0 minute; Accidentally beat soft leg phenomenon 1 minute; Take place frequently and beat soft leg phenomenon 2 minutes;
7. joint crunch or friction sense: no knee joint crunch or friction sense 0 minute; Knee joint crunch or friction sense 1 minute is arranged;
8. quadriceps femoris muscle atrophy: no quadriceps femoris muscle atrophy 0 minute; Quadriceps femoris muscle atrophy 1 minute is arranged.
3,100mm range estimation simulation pain scale line (VAS)
0 for not bitterly, and 1-3 representes mild pain, and 4-6 representes moderate pain, and 7-10 representes severe pain, and 10 is pain extremely, by the patient gonalgia rank circle on corresponding digital.
4, curative effect of disease evaluation criterion
Formulate with reference to " new Chinese medicine clinical research guideline " osteoarthritis efficacy assessment standard in 2002,
Clinical recovery: the gonalgia, swelling disappear, and it is normal that movable function recovers, and tenderness or floating patella test are negative, and the X ray examination is normal, and integrated value is >=95%;
Produce effects: the gonalgia, swelling disappear or obviously alleviate, and activity obviously improves, and tenderness or floating patella test are negative, and integrated value descends >=70%,＜95%;
Effectively: the gonalgia, swelling alleviate, and activity makes moderate progress, and tenderness or floating patella test are weak positive, and integrated value descends >=30%,＜70%;
Invalid: symptom, sign improvement do not reach above-mentioned standard person, even the person of increasing the weight of.
Adopt the nimodipine method to calculate, integration * 100% before therapeutic index=(integration before the treatment-treatment back integration)/treatment.
Statistical method
Use the SPSS13.0 statistical analysis software, measurement data adopts chi-square criterion.Measurement data is with F check or t check; Ranked data are used rank test.
Therapeutic outcome
Curative effect of disease is relatively after 2 weeks of medication:
Treatment group and treatment of control group knee osteoarthritis all have obvious curative effects.After treating 2 courses of treatment, treatment group effective percentage 87.0%, matched group effective percentage 84.4%.Two groups of treatment curative effects are similar, no difference of science of statistics.(result sees table 1).
Table 1: curative effect of disease relatively after 2 weeks of medication
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate (%) |
| The treatment group | 46 | 9 | 15 | 16 | 6 | 87.0 |
| Matched group | 45 | 7 | 16 | 15 | 7 | 84.4 |
Curative effect of disease is relatively after 1 week of drug withdrawal:
After 1 week of drug withdrawal, treatment group effective percentage 84.8%, matched group effective percentage 75.6%.Treatment group curative effect is superior to matched group, and significant difference is arranged.(result sees table 2).
Table 2: curative effect of disease relatively after 1 week of drug withdrawal
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate (%) |
| The treatment group | 46 | 9 | 14 | 16 | 7 | 84.8 |
| Matched group | 45 | 7 | 13 | 14 | 11 | 75.6 |
Safety is observed:
Row three big conventional, the no abnormal variations of hepatic and renal function examiner after two groups of patient's medications, the symptom aspect, treatment group and matched group all do not have discomforts such as the flatulence of appearance, inappetence, accomplish whole research process smoothly, and no case comes off.
The specific embodiment
Embodiment 1
A kind of medicine of treating osteoarthritis is that the medicine with following weight is a crude drug:
Olibanum (processed with vinegar) 3kg, Myrrha (processed with vinegar) 3kg, Radix Paeoniae Alba 6kg, Radix Notoginseng 3kg, Radix Lamiophlomidis Rotatae 2kg, Flos Carthami 3kg, Rhizoma Curcumae Longae 3kg, Sanguis Draxonis 1kg, Rhizoma Et Radix Notopterygii 3kg, Radix Angelicae Pubescentis 3kg, Radix Gentianae Macrophyllae 3kg, Radix Achyranthis Bidentatae 5kg, Ramulus Cinnamomi 3kg, Semen Strychni 3kg;
Wherein said Olibanum (processed with vinegar) and Myrrha (processed with vinegar) be with Olibanum with do not have the medicated vinegar parch to become, Semen Strychni (processed) is to process with Semen Strychni according to traditional method.
Concrete method for preparing is following:
Earlier Olibanum (processed with vinegar), Myrrha (processed with vinegar), Radix Notoginseng, Sanguis Draxonis and Semen Strychni (processed) five tastes crude drug are ground into 80 purpose fine powders, again all the other nine flavor crude drug being used mass fractions is 60% alcohol reflux 2 times, adds the ethanol of 6 times of amounts at every turn; Extracted 2 hours; Merge extractive liquid, filters, and collects medicinal residues; Reclaim ethanol, will cross then filterable extracting solution be condensed into temperature when being 55～65 ℃ relative density be 1.35 thick paste I; Get the medicinal residues decocte with water 2 times of collection again, add the water of 6 times of amounts at every turn, decocted 1 hour; Merge extractive liquid,, filtration, with extracting solution be condensed into temperature when being 75～85 ℃ relative density be 1.35 thick paste II, at last with fine powder, thick paste I and thick paste II mix homogeneously; Dry; Be ground into 80 purpose powder, in powder, add the starch mix homogeneously of powder weight 5% again, process capsule preparations.
Embodiment 2
A kind of medicine of treating osteoarthritis is that the medicine with following weight is a crude drug:
Olibanum (processed with vinegar) 4kg, Myrrha (processed with vinegar) 4kg, Radix Paeoniae Alba 10kg, Radix Notoginseng 6kg, Radix Lamiophlomidis Rotatae 4kg, Flos Carthami 7kg, Rhizoma Curcumae Longae 7kg, Sanguis Draxonis 2kg, Rhizoma Et Radix Notopterygii 7kg, Radix Angelicae Pubescentis 7kg, Radix Gentianae Macrophyllae 7kg, Radix Achyranthis Bidentatae 9kg, Ramulus Cinnamomi 7kg, Semen Strychni 5kg;
Wherein said Olibanum (processed with vinegar) and Myrrha (processed with vinegar) be with Olibanum with do not have the medicated vinegar parch to become, Semen Strychni (processed) is to process with Semen Strychni according to traditional method.
Concrete method for preparing is following:
Earlier Olibanum (processed with vinegar), Myrrha (processed with vinegar), Radix Notoginseng, Sanguis Draxonis and Semen Strychni (processed) five tastes crude drug are ground into 100 purpose fine powders, again all the other nine flavor crude drug being used mass fractions is 70% alcohol reflux 3 times, adds the ethanol of 8 times of amounts at every turn; Extracted 3 hours; Merge extractive liquid, filters, and collects medicinal residues; Reclaim ethanol, will cross then filterable extracting solution be condensed into temperature when being 55～65 ℃ relative density be 1.36 thick paste I; Get the medicinal residues decocte with water 3 times of collection again, add the water of 8 times of amounts at every turn, decocted 2 hours; Merge extractive liquid,, filtration, with extracting solution be condensed into temperature when being 75～85 ℃ relative density be 1.36 thick paste II, at last with fine powder, thick paste I and thick paste II mix homogeneously; Dry; Be ground into 100 purpose powder, in powder, add the starch mix homogeneously of powder weight 7% again, process capsule preparations.
Embodiment 3
A kind of medicine of treating osteoarthritis is that the medicine with following weight is a crude drug:
Olibanum (processed with vinegar) 5kg, Myrrha (processed with vinegar) 5kg, Radix Paeoniae Alba 15kg, Radix Notoginseng 9kg, Radix Lamiophlomidis Rotatae 6kg, Flos Carthami 10kg, Rhizoma Curcumae Longae 10kg, Sanguis Draxonis 3kg, Rhizoma Et Radix Notopterygii 10kg, Radix Angelicae Pubescentis 10kg, Radix Gentianae Macrophyllae 10kg, Radix Achyranthis Bidentatae 12kg, Ramulus Cinnamomi 10kg, Semen Strychni 6kg;
Wherein said Olibanum (processed with vinegar) and Myrrha (processed with vinegar) be with Olibanum with do not have the medicated vinegar parch to become, Semen Strychni (processed) is to process with Semen Strychni according to traditional method.
The concrete method for preparing of medicine is following:
Earlier Olibanum (processed with vinegar), Myrrha (processed with vinegar), Radix Notoginseng, Sanguis Draxonis and Semen Strychni (processed) five tastes crude drug are ground into 120 purpose fine powders, again all the other nine flavor crude drug being used mass fractions is 80% alcohol reflux 4 times, adds the ethanol of 10 times of amounts at every turn; Extracted 4 hours; Merge extractive liquid, filters, and collects medicinal residues; Reclaim ethanol, will cross then filterable extracting solution be condensed into temperature when being 55～65 ℃ relative density be 1.38 thick paste I; Get the medicinal residues decocte with water 4 times of collection again, add the water of 10 times of amounts at every turn, decocted 3 hours; Merge extractive liquid,, filtration, with extracting solution be condensed into temperature when being 75～85 ℃ relative density be 1.38 thick paste II, at last with fine powder, thick paste I and thick paste II mix homogeneously; Dry; Be ground into 120 purpose powder, in powder, add the starch mix homogeneously of powder weight 10% again, process capsule preparations.
Claims (2)
1. medicine of treating osteoarthritis is characterized in that with following parts of medicines by weight be crude drug:
Olibanum (processed with vinegar) 3～5, Myrrha (processed with vinegar) 3～5, the Radix Paeoniae Alba 6～15, Radix Notoginseng 3～9, Radix Lamiophlomidis Rotatae 2～6, Flos Carthami 3～10, Rhizoma Curcumae Longae 3～10, Sanguis Draxonis 1～3, Rhizoma Et Radix Notopterygii 3～10, Radix Angelicae Pubescentis 3～10, Radix Gentianae Macrophyllae 3～10, Radix Achyranthis Bidentatae 5～12, Ramulus Cinnamomi 3～10, Semen Strychni (processed) 3～6;
Wherein said Olibanum (processed with vinegar) and Myrrha (processed with vinegar) be with Olibanum with do not have the medicated vinegar parch to become, Semen Strychni (processed) is to process with Semen Strychni according to conventional method.
2. the method for preparing of the medicine of the described treatment osteoarthritis of claim 1; It is characterized in that: earlier Olibanum (processed with vinegar), Myrrha (processed with vinegar), Radix Notoginseng, Sanguis Draxonis and Semen Strychni (processed) five tastes crude drug are ground into 80～120 purpose fine powders, again all the other nine flavor crude drug being used mass fractions is 60～80% alcohol reflux 2～4 times, adds the ethanol of 6～10 times of amounts at every turn; Extracted 2～4 hours; Merge extractive liquid, filters, and collects medicinal residues; Reclaim ethanol, will cross then filterable extracting solution be condensed into temperature when being 55～65 ℃ relative density be 1.35～1.38 thick paste I; Get the medicinal residues decocte with water 2～4 times of collection again, add the water of 6～10 times of amounts at every turn, decocted 1～3 hour; Merge extractive liquid,, filtration, with extracting solution be condensed into temperature when being 75～85 ℃ relative density be 1.35～1.38 thick paste II, at last with fine powder, thick paste I and thick paste II mix homogeneously; Dry; Be ground into 80～120 purpose powder, in powder, add the starch mix homogeneously of powder weight 5～10% again, process capsule preparations.
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| CN110812464A (en) * | 2019-12-26 | 2020-02-21 | 陕西中医药大学 | Pharmaceutical composition for preventing and treating arthritis and preparation method thereof |
| CN116036158A (en) * | 2022-09-09 | 2023-05-02 | 山西黄河中药有限公司 | Pharmaceutical composition for treating gouty arthritis and preparation method thereof |
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| CN101966316A (en) * | 2009-07-28 | 2011-02-09 | 上海佰加壹医药有限公司 | Gujin pill pellet and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110812464A (en) * | 2019-12-26 | 2020-02-21 | 陕西中医药大学 | Pharmaceutical composition for preventing and treating arthritis and preparation method thereof |
| CN116036158A (en) * | 2022-09-09 | 2023-05-02 | 山西黄河中药有限公司 | Pharmaceutical composition for treating gouty arthritis and preparation method thereof |
| CN116036158B (en) * | 2022-09-09 | 2023-10-13 | 山西黄河中药有限公司 | Pharmaceutical composition for treating gouty arthritis and preparation method thereof |
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